E3 ubiquitin-ligase RNF185-like

Overview
NameE3 ubiquitin-ligase RNF185-like
Smed IDSMED30020665
Length (bp)1253
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of E3 ubiquitin-ligase RNF185-like (SMED30020665) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 ubiquitin-ligase RNF185-like (SMED30020665) in cells (dots) of each of the 12 neoblast clusters.

 

back to top


 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-ligase RNF185-like (SMED30020665) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-ligase RNF185-like (SMED30020665) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top


 

Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020




SMED30020665

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
posterior sideSMED30020665h1SMcG0002844 dd_Smed_v4_5004_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30020665h1SMcG0002844 dd_Smed_v4_5004_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783])

HSP 1 Score: 175.252 bits (443), Expect = 2.432e-52
Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1
Query:  160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783])

HSP 1 Score: 175.252 bits (443), Expect = 2.432e-52
Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1
Query:  160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068])

HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43
Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1
Query:  142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564
            G   GP      +  +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+  R  CPVCKA ISR+KV+PLYGR S   +DPR K PPRPQGQR   +           +    +P  DT G + SFG+GAFP G F T FN
Sbjct:    9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068])

HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43
Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1
Query:  142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564
            G   GP      +  +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+  R  CPVCKA ISR+KV+PLYGR S   +DPR K PPRPQGQR   +           +    +P  DT G + SFG+GAFP G F T FN
Sbjct:    9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068])

HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43
Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1
Query:  142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564
            G   GP      +  +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+  R  CPVCKA ISR+KV+PLYGR S   +DPR K PPRPQGQR   +           +    +P  DT G + SFG+GAFP G F T FN
Sbjct:    9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: rnf-5 (E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss-Prot;Acc:Q09463])

HSP 1 Score: 127.872 bits (320), Expect = 1.519e-34
Identity = 64/133 (48.12%), Postives = 89/133 (66.92%), Query Frame = 1
Query:  163 TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTF 561
            ++  + S  F+CNICL+ +KD V+S+CGHLFCWPCL +W++T+ +   CPVCK+AI  +KV+P+YGR   D  DPR K+PPRP+GQR+E     F+G     +G  +  G    V+ SFGIG FPL   A+ F
Sbjct:   15 SSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCKSAIDGNKVVPIYGRGG-DSSDPRKKVPPRPKGQRSEPPPQSFAGFNWGGDGGMMG-GGGPNVHFSFGIGIFPLSFVASFF 145          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: rnf-5 (E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss-Prot;Acc:Q09463])

HSP 1 Score: 120.939 bits (302), Expect = 9.287e-32
Identity = 49/89 (55.06%), Postives = 69/89 (77.53%), Query Frame = 1
Query:  163 TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTE 429
            ++  + S  F+CNICL+ +KD V+S+CGHLFCWPCL +W++T+ +   CPVCK+AI  +KV+P+YGR   D  DPR K+PPRP+GQR+E
Sbjct:   15 SSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCKSAIDGNKVVPIYGRGG-DSSDPRKKVPPRPKGQRSE 102          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: C32D5.11 (pep chromosome:WBcel235:II:6352542:6355911:-1 gene:WBGene00016318.1 transcript:C32D5.11.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32D5.11)

HSP 1 Score: 48.9062 bits (115), Expect = 6.316e-6
Identity = 25/66 (37.88%), Postives = 35/66 (53.03%), Query Frame = 1
Query:  154 GPETAGNNSSGSFDCNICL--EISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKV 345
             P T+ NN      C ICL    S++  I  C H FC+ C+  W+  QS R +CP+C+  +  DKV
Sbjct:   54 SPSTSSNNPVEELQCTICLSTRFSQECRIEGCNHSFCFSCISEWV-CQSLRPSCPMCRKDV--DKV 116          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074188)

HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48
Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1
Query:  130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            G+P G GT  +T  N              ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R  CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D                  G   G +MSFGIGAFP G   +T NF     P  +   R T  Y  +Q+  LSK+F  +A    +W
Sbjct:   95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074186)

HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48
Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1
Query:  130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            G+P G GT  +T  N              ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R  CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D                  G   G +MSFGIGAFP G   +T NF     P  +   R T  Y  +Q+  LSK+F  +A    +W
Sbjct:   95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074187)

HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48
Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1
Query:  130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            G+P G GT  +T  N              ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R  CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D                  G   G +MSFGIGAFP G   +T NF     P  +   R T  Y  +Q+  LSK+F  +A    +W
Sbjct:   95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074185)

HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48
Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1
Query:  130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            G+P G GT  +T  N              ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R  CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D                  G   G +MSFGIGAFP G   +T NF     P  +   R T  Y  +Q+  LSK+F  +A    +W
Sbjct:   95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074189)

HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48
Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1
Query:  130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            G+P G GT  +T  N              ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R  CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D                  G   G +MSFGIGAFP G   +T NF     P  +   R T  Y  +Q+  LSK+F  +A    +W
Sbjct:   95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310])

HSP 1 Score: 172.17 bits (435), Expect = 2.419e-51
Identity = 90/167 (53.89%), Postives = 108/167 (64.67%), Query Frame = 1
Query:  187 SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            +F+CNICL+ SKD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  ++ +Q   LS++FL +A     W
Sbjct:   38 TFECNICLDTSKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPG---TPQHTDEQ--FLSRLFLFVALLIMFW 190          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:100537822])

HSP 1 Score: 130.954 bits (328), Expect = 9.335e-36
Identity = 74/150 (49.33%), Postives = 86/150 (57.33%), Query Frame = 1
Query:  172 NNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAY 621
            +    +F+CNICL+ ++D VIS+CGHLFC             R  CPVCKA ISRDKVIPLYGR S+ Q DPR K PPRPQGQR+E +  G                 DTG +MSFGIGAFP G F T FN    NNP     F   DA+
Sbjct:   39 DRERATFECNICLDTARDAVISLCGHLFC-------------RQQCPVCKAGISRDKVIPLYGRGSSSQEDPRLKTPPRPQGQRSEPESRGPFQGFG-----------DTGFHMSFGIGAFPFGFFTTVFN---TNNP-----FHRADAH 156          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306])

HSP 1 Score: 55.4546 bits (132), Expect = 7.968e-8
Identity = 23/70 (32.86%), Postives = 39/70 (55.71%), Query Frame = 1
Query:  175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRD 384
            NS    +C ICL+  +  VI+ C H+FC PC+   I ++  +A CP+C+A I   +++   G  +  + D
Sbjct:  656 NSGSDEECAICLDSLRQPVITYCAHVFCRPCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAETRSD 725          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306])

HSP 1 Score: 55.4546 bits (132), Expect = 8.191e-8
Identity = 23/70 (32.86%), Postives = 39/70 (55.71%), Query Frame = 1
Query:  175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRD 384
            NS    +C ICL+  +  VI+ C H+FC PC+   I ++  +A CP+C+A I   +++   G  +  + D
Sbjct:  690 NSGSDEECAICLDSLRQPVITYCAHVFCRPCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAETRSD 759          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310])

HSP 1 Score: 45.4394 bits (106), Expect = 2.848e-6
Identity = 18/24 (75.00%), Postives = 22/24 (91.67%), Query Frame = 1
Query:  187 SFDCNICLEISKDTVISMCGHLFC 258
            +F+CNICL+ SKD VIS+CGHLFC
Sbjct:   38 TFECNICLDTSKDAVISLCGHLFC 61          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: supt16h (SPT16 homolog, facilitates chromatin remodeling subunit [Source:Xenbase;Acc:XB-GENE-979305])

HSP 1 Score: 162.155 bits (409), Expect = 1.097e-47
Identity = 81/168 (48.21%), Postives = 110/168 (65.48%), Query Frame = 1
Query:  190 FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPG-VDTGVNMSFGIGAFPLGLFATTFNFTGGNN-PQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            ++CNICLE +++ V+S+CGHL+CWPCLH+W+ET+  R  CPVCKA ISR+KVIP+YGR  ++Q+DPR K PPRPQGQR E +     G+          PG  DTG +MSFGIGAFP G F T FN    ++ P+ D    ++  + +  S     +FL+IA   F+W
Sbjct:   12 YECNICLETAREPVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVIPIYGRGDSNQKDPRLKTPPRPQGQRPEPENRAGGGV----------PGFTDTGFHMSFGIGAFPFGFFTTVFNTNDLHSAPRADTGLPQSRFFGLPDS-----LFLIIAAFFFLW 164          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783])

HSP 1 Score: 149.443 bits (376), Expect = 1.505e-42
Identity = 89/193 (46.11%), Postives = 114/193 (59.07%), Query Frame = 1
Query:  109 STNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            S   S+ G  SGS  G E +  +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISR+KVIPLYGR ST Q DPR+K PPRPQGQR E +  G  GI            +D   + SF + A  +  F+  F+   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   11 SAENSSPGGASGSTNG-EASSQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISREKVIPLYGRGSTGQEDPREKTPPRPQGQRPEPENRGSQGIKF----------IDGDFSSSFSV-ANCIFTFSICFDVNDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 184          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: HLTF (helicase-like transcription factor [Source:NCBI gene;Acc:394525])

HSP 1 Score: 53.1434 bits (126), Expect = 6.611e-7
Identity = 22/58 (37.93%), Postives = 37/58 (63.79%), Query Frame = 1
Query:  178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348
            SSGS  +C ICL+     VI+ C H+FC PC+ + I+ +   A CP+C+ ++  D+++
Sbjct:  728 SSGSDEECAICLDSLNMPVITYCAHVFCKPCICQVIQHEKQEAKCPLCRGSLRLDQLV 785          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: HLTF (helicase-like transcription factor [Source:NCBI gene;Acc:394525])

HSP 1 Score: 53.1434 bits (126), Expect = 7.038e-7
Identity = 22/58 (37.93%), Postives = 37/58 (63.79%), Query Frame = 1
Query:  178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348
            SSGS  +C ICL+     VI+ C H+FC PC+ + I+ +   A CP+C+ ++  D+++
Sbjct:  735 SSGSDEECAICLDSLNMPVITYCAHVFCKPCICQVIQHEKQEAKCPLCRGSLRLDQLV 792          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: chrng (cholinergic receptor, nicotinic gamma [Source:Xenbase;Acc:XB-GENE-990010])

HSP 1 Score: 50.8322 bits (120), Expect = 1.806e-6
Identity = 20/54 (37.04%), Postives = 31/54 (57.41%), Query Frame = 1
Query:  193 DCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPL 354
             C +CLE+ +    + CGHLFCW C+  W  T++    CP+C+   S  K++ L
Sbjct:  270 KCTLCLEVRRHCTATPCGHLFCWECITEWCNTKTE---CPLCREKFSPQKLVYL 320          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf185 (ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078])

HSP 1 Score: 187.193 bits (474), Expect = 3.518e-57
Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + ST  SN+G PSGS  G   +G   S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:    9 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf185 (ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078])

HSP 1 Score: 185.267 bits (469), Expect = 6.289e-56
Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + ST  SN+G PSGS  G   +G   S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   45 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 224          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf5 (ring finger protein 5 [Source:MGI Symbol;Acc:MGI:1860076])

HSP 1 Score: 150.984 bits (380), Expect = 1.821e-43
Identity = 71/141 (50.35%), Postives = 89/141 (63.12%), Query Frame = 1
Query:  142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFN 564
            G   GP      +S +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+  R  CPVCKA ISR+KV+PLYGR S   +DPR K PPRPQGQR   +  G               G   G + SFG+GAFP G F T FN
Sbjct:    9 GGPEGPNRERGGASATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPF----------GDAGGFHFSFGVGAFPFGFFTTVFN 139          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Brca1 (breast cancer 1, early onset [Source:MGI Symbol;Acc:MGI:104537])

HSP 1 Score: 45.8246 bits (107), Expect = 3.319e-6
Identity = 17/49 (34.69%), Postives = 30/49 (61.22%), Query Frame = 1
Query:  190 FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISR 336
             +C ICLE+ K+ V + C H+FC  C+ + +  +   + CP+CK  I++
Sbjct:   22 LECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITK 70          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Hltf (helicase-like transcription factor [Source:MGI Symbol;Acc:MGI:1196437])

HSP 1 Score: 50.447 bits (119), Expect = 3.518e-6
Identity = 23/58 (39.66%), Postives = 35/58 (60.34%), Query Frame = 1
Query:  178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348
            SSGS  +C ICL+     VI+ C H+FC PC+ + I ++   A CP+C+  I  D ++
Sbjct:  747 SSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNLL 804          
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q91YT2|RN185_MOUSE (E3 ubiquitin-protein ligase RNF185 OS=Mus musculus OX=10090 GN=Rnf185 PE=2 SV=1)

HSP 1 Score: 187.193 bits (474), Expect = 2.461e-56
Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + ST  SN+G PSGS  G   +G   S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:    9 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q568Y3|RN185_RAT (E3 ubiquitin-protein ligase RNF185 OS=Rattus norvegicus OX=10116 GN=Rnf185 PE=2 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 1.168e-51
Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1
Query:  160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q96GF1|RN185_HUMAN (E3 ubiquitin-protein ligase RNF185 OS=Homo sapiens OX=9606 GN=RNF185 PE=1 SV=1)

HSP 1 Score: 175.252 bits (443), Expect = 1.168e-51
Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1
Query:  160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q5RFK9|RN185_PONAB (E3 ubiquitin-protein ligase RNF185 OS=Pongo abelii OX=9601 GN=RNF185 PE=2 SV=1)

HSP 1 Score: 174.096 bits (440), Expect = 2.387e-51
Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1
Query:  160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q5ZIR9|RN185_CHICK (E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus OX=9031 GN=RNF185 PE=2 SV=1)

HSP 1 Score: 174.096 bits (440), Expect = 3.424e-51
Identity = 91/171 (53.22%), Postives = 108/171 (63.16%), Query Frame = 1
Query:  175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            N   +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:   34 NQDNTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 190          
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A1W4X226 (E3 ubiquitin-protein ligase RNF185-like OS=Agrilus planipennis OX=224129 GN=LOC108740347 PE=4 SV=1)

HSP 1 Score: 184.882 bits (468), Expect = 5.142e-53
Identity = 99/201 (49.25%), Postives = 121/201 (60.20%), Query Frame = 1
Query:  100 MAESTNTSNSGFPSGSGTGPETAGNNSSG--SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV---DTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            MA S N S    PS S  G    G++     +F+CNICL+ +KD V+SMCGHLFCWPCLH+W+ET+ SR  CPVCKAAIS+DKVIPLYGR ST+Q+DPR+K+PPRP GQRTE +                 PG    D G +MSFGIGAFP G F +TFNF         PN          + + LSK+FL +A     W
Sbjct:    1 MASSKNESE---PSSSKAGVSGEGDDKKEDRTFECNICLDTAKDAVVSMCGHLFCWPCLHQWLETRLSRQVCPVCKAAISKDKVIPLYGRGSTNQQDPREKVPPRPAGQRTEPESGSNF------------PGFGFGDNGFHMSFGIGAFPFGFFTSTFNFG-----DVRPNAAPLGTPQHMEEQFLSKIFLWLAFLFIAW 181          
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A087UTJ1 (E3 ubiquitin-protein ligase RNF185 (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_10572 PE=4 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 5.931e-53
Identity = 97/186 (52.15%), Postives = 120/186 (64.52%), Query Frame = 1
Query:  145 SGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV---DTGVNMSFGIGAFPLGLFATTFNFTGGN--NPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            SG G E       G+F+CNICL+ +KD V+S+CGHLFCWPCLHRW+ET+ SR  CPVCKAAISR+KVIPLYGR  ++Q DPR+++PPRP GQRTE + +               PG    DTG +MSFGIGAFP G+FA++FNF  G    P   P F E         +LLSKVFL +A    +W
Sbjct:    8 SGGGSEET-RTQEGTFECNICLDTAKDAVVSLCGHLFCWPCLHRWLETRPSRQVCPVCKAAISREKVIPLYGRGGSNQ-DPRERLPPRPSGQRTEPENHAGQSF----------PGFGFGDTGFHMSFGIGAFPFGIFASSFNFGDGRPAPPPGTPEFEE--------DQLLSKVFLYVAIAFIVW 173          
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A1S3A4N2 (E3 ubiquitin-protein ligase RNF185 isoform X1 OS=Erinaceus europaeus OX=9365 GN=RNF185 PE=4 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 6.421e-53
Identity = 101/195 (51.79%), Postives = 124/195 (63.59%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + S   S++G PSG+G G E+ G +S+  F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:    9 SASPENSSAGGPSGNGAG-ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 186          
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A3M7QLX5 (E3 ubiquitin-ligase RNF185-like OS=Brachionus plicatilis OX=10195 GN=BpHYR1_035672 PE=4 SV=1)

HSP 1 Score: 183.726 bits (465), Expect = 1.164e-52
Identity = 91/161 (56.52%), Postives = 114/161 (70.81%), Query Frame = 1
Query:  139 SGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNN----PQNDPNFRE 609
            S SG   E + +N+S  ++CNICLE +KD VISMCGHLFCWPCLH+W+ET+    TCPVCK+AI++DKVIPLYGR+S+++ DPRDKIPPRPQGQRTE+ RN F              G+D G+++SFGIGAFP   FA+TFNFT  N     P   P + E
Sbjct:    9 SKSGKNNENSSDNASSQYECNICLETAKDAVISMCGHLFCWPCLHKWLETKPLNQTCPVCKSAINKDKVIPLYGRNSSNKTDPRDKIPPRPQGQRTEAPRNNFFAS-----------GLD-GLHVSFGIGAFPFSFFASTFNFTTDNRMPAPPPGSPQYAE 157          
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: H9Z0M5 (RING finger protein 185 isoform 1 OS=Macaca mulatta OX=9544 GN=RNF185 PE=2 SV=1)

HSP 1 Score: 183.341 bits (464), Expect = 2.059e-52
Identity = 100/195 (51.28%), Postives = 120/195 (61.54%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + S   S +G PSGS  G   +G   S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  Y  +Q   LS++FL +A     W
Sbjct:    9 SASPENSTAGSPSGSSNGAGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310])

HSP 1 Score: 181.03 bits (458), Expect = 6.357e-55
Identity = 93/186 (50.00%), Postives = 117/186 (62.90%), Query Frame = 1
Query:  139 SGSGTGPETAGNNSS--GSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV-DTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            + +G+  + +G +SS   +F+CNICL+ SKD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR++ PPRPQGQR E +               VR G  D G  MSFGIGAFP G+FAT FN   G  P   P   +         + LS++FL +A     W
Sbjct:   18 TATGSSGQASGESSSQDSTFECNICLDTSKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPRERTPPRPQGQRPEPEN------------RGVRFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPGTPQH-----MDEQFLSRLFLFVALVIMFW 186          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:103046714])

HSP 1 Score: 170.244 bits (430), Expect = 8.212e-51
Identity = 91/176 (51.70%), Postives = 106/176 (60.23%), Query Frame = 1
Query:  100 MAESTNTSNSGFPSGSGTGP-ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYS 624
            MA +    + G     G G  E  G+    +F+CNICL+ ++D VIS+CGHLFCWPCLH+W+ET+ SR  CPVCKA ISRDKVIPLYGR ST Q DPR K PPRPQGQRTE +  G                 DTG +MSFGIGAFP G F T FN        NDP  R    Y+
Sbjct:    1 MAAAAEPRSGGEGHHPGDGDRERDGDGDRAAFECNICLDTARDAVISLCGHLFCWPCLHQWLETRPSRQQCPVCKAGISRDKVIPLYGRGSTSQEDPRLKTPPRPQGQRTEPESRGPFHGFG-----------DTGFHMSFGIGAFPFGFFTTVFN-------TNDPFHRADPHYA 158          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: ENSAMXT00000052741.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000182.1:466606:473602:1 gene:ENSAMXG00000043276.1 transcript:ENSAMXT00000052741.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.6026 bits (122), Expect = 8.285e-7
Identity = 27/58 (46.55%), Postives = 36/58 (62.07%), Query Frame = 1
Query:  151 TGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKA 324
            T P    N +S +  C+ICLE+  D V + CGH FC  CL ++ ++ SSR  CPVCKA
Sbjct:    2 TLPNNVQNLTSEAKPCSICLEVFNDPVSTPCGHNFCVVCLRQYWDS-SSRCQCPVCKA 58          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: pex10 (peroxisomal biogenesis factor 10 [Source:NCBI gene;Acc:103034252])

HSP 1 Score: 50.8322 bits (120), Expect = 1.290e-6
Identity = 22/70 (31.43%), Postives = 36/70 (51.43%), Query Frame = 1
Query:  151 TGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYG 360
            + P+   + SS +  C +CLE  +    + CGHLFCW C+  W  T   +  CP+C+      +++ L G
Sbjct:  257 SSPQAVRSPSSKTSRCILCLEERRHPTTTPCGHLFCWECITEWCNT---KMECPLCREKFQPHRLVYLRG 323          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306])

HSP 1 Score: 50.8322 bits (120), Expect = 2.021e-6
Identity = 24/68 (35.29%), Postives = 40/68 (58.82%), Query Frame = 1
Query:  193 DCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDK 396
            +C +CL+  +  VI+ C H+FC PC+   I+++   A CP+C+A I   +++  Y  D  D R P D+
Sbjct:  731 ECAVCLDSLRQPVITHCAHVFCKPCICEVIQSKQLAAKCPLCRANIKSTELLE-YPGDEEDSR-PTDR 796          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Yeast
Match: IRC20 (E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000004237])

HSP 1 Score: 52.373 bits (124), Expect = 9.982e-8
Identity = 27/87 (31.03%), Postives = 43/87 (49.43%), Query Frame = 1
Query:  175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESD 435
            N +    C+ICL   +   I  CGH FC  C+  W+   S    CP+CK   S  +V     ++ST++R+ ++   PR +G  +  D
Sbjct: 1232 NDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSK---CPICKGFCSISEVYNFKFKNSTEKRE-KEIQEPRREGADSSQD 1314          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO37344 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFY7])

HSP 1 Score: 168.318 bits (425), Expect = 1.413e-50
Identity = 86/177 (48.59%), Postives = 114/177 (64.41%), Query Frame = 1
Query:  157 PETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            P    N+++ +F+CNICL+ ++D VISMCGHLFCWPCLHRW+ET+ +R+ CPVCKA IS++KVIPL+GR S+  +DPR+K+PPRPQ QRTE + NG               G   G  +SFGIGAFP   F+TT    GGNNPQ+        +   +  + LSK+FL +A     W
Sbjct:   22 PSEDPNSANANFECNICLDTARDAVISMCGHLFCWPCLHRWLETRPNRSMCPVCKAGISKEKVIPLFGRGSSSNQDPREKMPPRPQAQRTEPENNGTFAGFG---------GFGDGFQLSFGIGAFPFAFFSTTL---GGNNPQHP---APPGSPQAEDEQFLSKLFLWVAFLFMFW 183          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO40992 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K6])

HSP 1 Score: 51.6026 bits (122), Expect = 2.337e-7
Identity = 21/72 (29.17%), Postives = 37/72 (51.39%), Query Frame = 1
Query:  157 PETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDST 372
            P     +  G+  C++CLE  K    + CGHLFCW C+  W  ++     CP+C+  +   +++ L+  + T
Sbjct:  229 PSVVPQSMPGTLKCSLCLENVKHITSTSCGHLFCWHCITEWCSSK-----CPLCREPLQMSRLVYLHHFEPT 295          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO30997 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ68])

HSP 1 Score: 42.3578 bits (98), Expect = 9.526e-6
Identity = 18/46 (39.13%), Postives = 28/46 (60.87%), Query Frame = 1
Query:  196 CNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAIS 333
            C IC E+    + + C H FC  C+  W++   +++ CPVCKA+IS
Sbjct:   16 CAICKEVLTQPIATPCDHYFCVLCICEWLDQTYNKSGCPVCKASIS 61          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:101167555])

HSP 1 Score: 170.244 bits (430), Expect = 8.516e-51
Identity = 88/167 (52.69%), Postives = 108/167 (64.67%), Query Frame = 1
Query:  187 SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R  CPVCKA ISRDKVIPLYGR ST Q+DPR++ PPRPQGQR E +  G                 D G  MSFGIGAFP G+FAT FN   G  P   P    T  ++ +Q   LS++FL +A     W
Sbjct:   36 TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPRERTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPG---TPQHTDEQ--FLSRLFLFVALVIMFW 188          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:101175247])

HSP 1 Score: 168.703 bits (426), Expect = 3.718e-50
Identity = 92/181 (50.83%), Postives = 106/181 (58.56%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPE-------TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYS 624
            A     S  GFP+G  +                  +F+CNICL+ ++D VISMCGHLFCWPCLH+W+ETQ SR  CPVCKA ISR+KVIPLYGR S+ Q DPR K PPRPQGQRTE +  G    G            DTG +MSFGIGAFP G F T FN        NDP F   D Y+
Sbjct:    3 AADPRYSRGGFPAGESSNDRDGPGGGSGESERDRATFECNICLDTARDAVISMCGHLFCWPCLHQWLETQPSRQQCPVCKAGISREKVIPLYGRGSSSQEDPRLKTPPRPQGQRTEPESRGGMFQGFG----------DTGFHMSFGIGAFPFGFFTTVFN-------ANDP-FHRADQYA 165          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:101175247])

HSP 1 Score: 131.724 bits (330), Expect = 3.602e-36
Identity = 82/179 (45.81%), Postives = 96/179 (53.63%), Query Frame = 1
Query:  103 AESTNTSNSGFPSGSGTGPE-------TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWP-CLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETD 615
            A     S  GFP+G  +                  +F+CNICL+ ++D VISM      +P C  +W+ETQ SR  CPVCKA ISR+KVIPLYGR S+ Q DPR K PPRPQGQRTE +  G    G            DTG +MSFGIGAFP G F T FN        NDP  R  D
Sbjct:    3 AADPRYSRGGFPAGESSNDRDGPGGGSGESERDRATFECNICLDTARDAVISM------YPSCPSQWLETQPSRQQCPVCKAGISREKVIPLYGRGSSSQEDPRLKTPPRPQGQRTEPESRGGMFQGFG----------DTGFHMSFGIGAFPFGFFTTVFN-------ANDPFHRAGD 158          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: rfwd3 (ring finger and WD repeat domain 3 [Source:NCBI gene;Acc:101171660])

HSP 1 Score: 50.447 bits (119), Expect = 2.382e-6
Identity = 23/60 (38.33%), Postives = 32/60 (53.33%), Query Frame = 1
Query:  196 CNICLE---ISKDTVISM--CGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYG 360
            C IC E    + +  +S   CGHLF + C+HRW++ Q S A CP C     R  ++ LY 
Sbjct:  208 CTICFESWTTAGEHRLSALRCGHLFGYTCIHRWLKAQGSAAKCPQCNKKAKRSDIVLLYA 267          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: hltf (helicase like transcription factor [Source:NCBI gene;Acc:101157336])

HSP 1 Score: 49.6766 bits (117), Expect = 4.494e-6
Identity = 19/68 (27.94%), Postives = 40/68 (58.82%), Query Frame = 1
Query:  178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQ 378
            +SGS  +C++CL+  +  VI+ C H++C PC+ + I  +  +  CP+C++ I   +++     D  ++
Sbjct:  788 ASGSDEECSVCLDSIRLPVITHCAHVYCRPCIAQVISNEQEKPRCPLCRSEIKSSELVEFPQEDMEEE 855          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Match: SMESG000060298.1 (SMESG000060298.1)

HSP 1 Score: 370.163 bits (949), Expect = 7.448e-129
Identity = 195/196 (99.49%), Postives = 195/196 (99.49%), Query Frame = 1
Query:  100 MAESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687
            MAESTNTSNSGFPSGSG GPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRNGFSGIGNIFNGFNVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW
Sbjct:    1 MAESTNTSNSGFPSGSGAGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRNGFSGIGNIFNGFNVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 196          
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Match: SMESG000016669.1 (SMESG000016669.1)

HSP 1 Score: 111.309 bits (277), Expect = 1.025e-28
Identity = 48/86 (55.81%), Postives = 64/86 (74.42%), Query Frame = 1
Query:  181 SGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQ-SSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESD 435
            + + DCNICLE S  +V++ CGH+FCWPC+  WIE Q S+   CPVCKA IS DK+IP+YG++S +Q DPR+ IPPRP  Q +E +
Sbjct:   13 NSNLDCNICLEESTQSVVTYCGHVFCWPCIFTWIEVQNSTENICPVCKAVISVDKLIPIYGQNS-NQIDPRNTIPPRPLAQYSEQN 97          
The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RNF1852.432e-5252.84ring finger protein 185 [Source:HGNC Symbol;Acc:HG... [more]
RNF1852.432e-5252.84ring finger protein 185 [Source:HGNC Symbol;Acc:HG... [more]
RNF52.147e-4350.00ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC... [more]
RNF52.147e-4350.00ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC... [more]
RNF52.147e-4350.00ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3
Match NameE-valueIdentityDescription
rnf-51.519e-3448.12E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss... [more]
rnf-59.287e-3255.06E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss... [more]
C32D5.116.316e-637.88pep chromosome:WBcel235:II:6352542:6355911:-1 gene... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG89742.637e-4846.15gene:FBgn0030693 transcript:FBtr0074188[more]
CG89742.637e-4846.15gene:FBgn0030693 transcript:FBtr0074186[more]
CG89742.637e-4846.15gene:FBgn0030693 transcript:FBtr0074187[more]
CG89742.637e-4846.15gene:FBgn0030693 transcript:FBtr0074185[more]
CG89742.637e-4846.15gene:FBgn0030693 transcript:FBtr0074189[more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1852.419e-5153.89ring finger protein 185 [Source:NCBI gene;Acc:4063... [more]
RNF59.335e-3649.33ring finger protein 5 [Source:NCBI gene;Acc:100537... [more]
hltf7.968e-832.86helicase-like transcription factor [Source:ZFIN;Ac... [more]
hltf8.191e-832.86helicase-like transcription factor [Source:ZFIN;Ac... [more]
rnf1852.848e-675.00ring finger protein 185 [Source:NCBI gene;Acc:4063... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
supt16h1.097e-4748.21SPT16 homolog, facilitates chromatin remodeling su... [more]
RNF1851.505e-4246.11ring finger protein 185 [Source:HGNC Symbol;Acc:HG... [more]
HLTF6.611e-737.93helicase-like transcription factor [Source:NCBI ge... [more]
HLTF7.038e-737.93helicase-like transcription factor [Source:NCBI ge... [more]
chrng1.806e-637.04cholinergic receptor, nicotinic gamma [Source:Xenb... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rnf1853.518e-5752.31ring finger protein 185 [Source:MGI Symbol;Acc:MGI... [more]
Rnf1856.289e-5652.31ring finger protein 185 [Source:MGI Symbol;Acc:MGI... [more]
Rnf51.821e-4350.35ring finger protein 5 [Source:MGI Symbol;Acc:MGI:1... [more]
Brca13.319e-634.69breast cancer 1, early onset [Source:MGI Symbol;Ac... [more]
Hltf3.518e-639.66helicase-like transcription factor [Source:MGI Sym... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q91YT2|RN185_MOUSE2.461e-5652.31E3 ubiquitin-protein ligase RNF185 OS=Mus musculus... [more]
sp|Q568Y3|RN185_RAT1.168e-5152.84E3 ubiquitin-protein ligase RNF185 OS=Rattus norve... [more]
sp|Q96GF1|RN185_HUMAN1.168e-5152.84E3 ubiquitin-protein ligase RNF185 OS=Homo sapiens... [more]
sp|Q5RFK9|RN185_PONAB2.387e-5152.84E3 ubiquitin-protein ligase RNF185 OS=Pongo abelii... [more]
sp|Q5ZIR9|RN185_CHICK3.424e-5153.22E3 ubiquitin-protein ligase RNF185 OS=Gallus gallu... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1W4X2265.142e-5349.25E3 ubiquitin-protein ligase RNF185-like OS=Agrilus... [more]
A0A087UTJ15.931e-5352.15E3 ubiquitin-protein ligase RNF185 (Fragment) OS=S... [more]
A0A1S3A4N26.421e-5351.79E3 ubiquitin-protein ligase RNF185 isoform X1 OS=E... [more]
A0A3M7QLX51.164e-5256.52E3 ubiquitin-ligase RNF185-like OS=Brachionus plic... [more]
H9Z0M52.059e-5251.28RING finger protein 185 isoform 1 OS=Macaca mulatt... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1856.357e-5550.00ring finger protein 185 [Source:NCBI gene;Acc:4063... [more]
RNF58.212e-5151.70ring finger protein 5 [Source:NCBI gene;Acc:103046... [more]
ENSAMXT00000052741.18.285e-746.55pep primary_assembly:Astyanax_mexicanus-2.0:APWO02... [more]
pex101.290e-631.43peroxisomal biogenesis factor 10 [Source:NCBI gene... [more]
hltf2.021e-635.29helicase-like transcription factor [Source:ZFIN;Ac... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
IRC209.982e-831.03E3 ubiquitin ligase and putative helicase; involve... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO373441.413e-5048.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO409922.337e-729.17Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO309979.526e-639.13Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rnf1858.516e-5152.69ring finger protein 185 [Source:NCBI gene;Acc:1011... [more]
RNF53.718e-5050.83ring finger protein 5 [Source:NCBI gene;Acc:101175... [more]
RNF53.602e-3645.81ring finger protein 5 [Source:NCBI gene;Acc:101175... [more]
rfwd32.382e-638.33ring finger and WD repeat domain 3 [Source:NCBI ge... [more]
hltf4.494e-627.94helicase like transcription factor [Source:NCBI ge... [more]
back to top
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000060298.17.448e-12999.49SMESG000060298.1[more]
SMESG000016669.11.025e-2855.81SMESG000016669.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020665 ID=SMED30020665|Name=E3 ubiquitin-ligase RNF185-like|organism=Schmidtea mediterranea sexual|type=transcript|length=1253bp
AATGTTTAAAAAATTTATTAATTATATTATATTGTCTCTGTAATTAAATT
TTTAAATATAATTGATTAAACAATTATAGCCGATTTTAGCAAAAATTAAA
TGGCTGAAAGTACAAATACTAGTAATTCAGGTTTTCCTAGTGGATCTGGA
ACAGGTCCCGAAACAGCAGGAAATAATTCGAGTGGTTCTTTTGATTGTAA
TATTTGTTTGGAAATATCTAAAGATACAGTTATTAGTATGTGTGGGCATT
TATTTTGTTGGCCATGTCTGCATCGGTGGATAGAAACCCAAAGTTCACGT
GCAACATGCCCTGTCTGTAAAGCAGCAATAAGCAGGGATAAAGTGATTCC
CTTGTACGGTCGTGATAGCACAGATCAAAGAGATCCTAGAGATAAAATTC
CTCCACGGCCTCAAGGTCAACGTACCGAATCCGACAGAAATGGATTTAGC
GGCATTGGTAATATATTTAATGGATTCAATGTCAGGCCAGGTGTTGATAC
CGGAGTCAACATGTCCTTTGGCATAGGAGCTTTTCCTCTCGGTCTTTTTG
CAACCACATTTAATTTCACCGGCGGAAACAATCCTCAAAATGATCCTAAT
TTTAGAGAAACAGATGCCTATTCTATTCAGCAAAGCGAATTATTATCCAA
AGTGTTTTTACTAATCGCAGGATGTTGTTTCATTTGGCTTTTATTAGCGT
GATATTTACCGTTAAAGATACTATTATAATTTAAAAGGCAAATAAATTAC
TGATCATTTATAAATTTCAATTTAAATTTATGCATATTTTAAAATTTTGT
GCAATTCACAATTTAATTACTATAATTGTTTAATTAAATAACTTGTGTTT
GTTTGTAATGAATTTGGCGGTAATTTATTTTTAATAAAACATGGTAATCA
TGTTAATTTTTTAACAAAAATACTTAGTTAACATTTATTGATAATGTTCT
ACTGTTGTGTATAGAATAAAACATGGTAATCATCTTTATTATTATTTTAG
CGTAACAAAATACATCATCTACATAGATGAACCTAACCCAATGTTTTGTA
CTCTGTCAGACTTCAGTACTGTTCGCGACAAAAACATGAATGGTATTTGT
GTTCCATGTGCATGGTGTACATATTATGTACATCAGTTTTGTGCCATAAA
TTAAATTTCTTGACTTATAAAGTTAGGAAAACAATTATTTTTGTAATTTA
AATTGTCCATTTTATAACTGTTTGACTATTAAATTGTAGTCTTATTACAA
AAA
back to top

protein sequence of SMED30020665-orf-1

>SMED30020665-orf-1 ID=SMED30020665-orf-1|Name=SMED30020665-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=201bp
MAESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGH
LFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKI
PPRPQGQRTESDRNGFSGIGNIFNGFNVRPGVDTGVNMSFGIGAFPLGLF
ATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIWLLLA
*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0016874ligase activity
GO:0008270zinc ion binding
GO:0005515protein binding
GO:0016740transferase activity
GO:0044390ubiquitin-like protein conjugating enzyme binding
GO:0046872metal ion binding
GO:1904264ubiquitin protein ligase activity involved in ERAD pathway
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR001841Znf_RING
IPR013083Znf_RING/FYVE/PHD
IPR017907Znf_RING_CS
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
GO:0005741mitochondrial outer membrane
GO:0005783endoplasmic reticulum
GO:0005789endoplasmic reticulum membrane
GO:0016020membrane
GO:0016021integral component of membrane
GO:0036513Derlin-1 retrotranslocation complex
Vocabulary: biological process
TermDefinition
GO:0006914autophagy
GO:0016567protein ubiquitination
GO:0030433ubiquitin-dependent ERAD pathway
GO:0036503ERAD pathway
GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051865protein autoubiquitination
GO:0071712ER-associated misfolded protein catabolic process
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001841Zinc finger, RING-typeSMARTSM00184ring_2coord: 33..73
e-value: 2.0E-8
score: 44.0
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 33..74
score: 13.64
NoneNo IPR availablePFAMPF13920zf-C3HC4_3coord: 32..78
e-value: 7.0E-10
score: 38.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 85..106
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 84..114
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..23
NoneNo IPR availablePANTHERPTHR12313RNF5coord: 3..198
NoneNo IPR availablePANTHERPTHR12313:SF13E3 UBIQUITIN-PROTEIN LIGASE RNF185coord: 3..198
NoneNo IPR availableCDDcd16534RING-HC_RNF5_likecoord: 32..74
e-value: 1.11369E-24
score: 89.0284
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 30..86
NoneNo IPR availableTMHMMTMhelixcoord: 135..157
NoneNo IPR availableTMHMMTMhelixcoord: 177..199
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 20..87
e-value: 2.2E-18
score: 67.4
IPR017907Zinc finger, RING-type, conserved sitePROSITEPS00518ZF_RING_1coord: 48..57