E3 ubiquitin-ligase RNF185-like
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020665 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783]) HSP 1 Score: 175.252 bits (443), Expect = 2.432e-52 Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1 Query: 160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783]) HSP 1 Score: 175.252 bits (443), Expect = 2.432e-52 Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1 Query: 160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068]) HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43 Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1 Query: 142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564 G GP + +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+ R CPVCKA ISR+KV+PLYGR S +DPR K PPRPQGQR + + +P DT G + SFG+GAFP G F T FN Sbjct: 9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068]) HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43 Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1 Query: 142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564 G GP + +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+ R CPVCKA ISR+KV+PLYGR S +DPR K PPRPQGQR + + +P DT G + SFG+GAFP G F T FN Sbjct: 9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Match: RNF5 (ring finger protein 5 [Source:HGNC Symbol;Acc:HGNC:10068]) HSP 1 Score: 151.369 bits (381), Expect = 2.147e-43 Identity = 71/142 (50.00%), Postives = 91/142 (64.08%), Query Frame = 1 Query: 142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDT-GVNMSFGIGAFPLGLFATTFN 564 G GP + +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+ R CPVCKA ISR+KV+PLYGR S +DPR K PPRPQGQR + + +P DT G + SFG+GAFP G F T FN Sbjct: 9 GGPEGPNRERGGAGATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPERQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPE-----------SRGGFQPFGDTGGFHFSFGVGAFPFGFFTTVFN 139
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: rnf-5 (E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss-Prot;Acc:Q09463]) HSP 1 Score: 127.872 bits (320), Expect = 1.519e-34 Identity = 64/133 (48.12%), Postives = 89/133 (66.92%), Query Frame = 1 Query: 163 TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTF 561 ++ + S F+CNICL+ +KD V+S+CGHLFCWPCL +W++T+ + CPVCK+AI +KV+P+YGR D DPR K+PPRP+GQR+E F+G +G + G V+ SFGIG FPL A+ F Sbjct: 15 SSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCKSAIDGNKVVPIYGRGG-DSSDPRKKVPPRPKGQRSEPPPQSFAGFNWGGDGGMMG-GGGPNVHFSFGIGIFPLSFVASFF 145
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: rnf-5 (E3 ubiquitin ligase rnf-5 [Source:UniProtKB/Swiss-Prot;Acc:Q09463]) HSP 1 Score: 120.939 bits (302), Expect = 9.287e-32 Identity = 49/89 (55.06%), Postives = 69/89 (77.53%), Query Frame = 1 Query: 163 TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTE 429 ++ + S F+CNICL+ +KD V+S+CGHLFCWPCL +W++T+ + CPVCK+AI +KV+P+YGR D DPR K+PPRP+GQR+E Sbjct: 15 SSNKDESARFECNICLDAAKDAVVSLCGHLFCWPCLSQWLDTRPNNQVCPVCKSAIDGNKVVPIYGRGG-DSSDPRKKVPPRPKGQRSE 102
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Match: C32D5.11 (pep chromosome:WBcel235:II:6352542:6355911:-1 gene:WBGene00016318.1 transcript:C32D5.11.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C32D5.11) HSP 1 Score: 48.9062 bits (115), Expect = 6.316e-6 Identity = 25/66 (37.88%), Postives = 35/66 (53.03%), Query Frame = 1 Query: 154 GPETAGNNSSGSFDCNICL--EISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKV 345 P T+ NN C ICL S++ I C H FC+ C+ W+ QS R +CP+C+ + DKV Sbjct: 54 SPSTSSNNPVEELQCTICLSTRFSQECRIEGCNHSFCFSCISEWV-CQSLRPSCPMCRKDV--DKV 116
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074188) HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48 Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1 Query: 130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 G+P G GT +T N ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D G G +MSFGIGAFP G +T NF P + R T Y +Q+ LSK+F +A +W Sbjct: 95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074186) HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48 Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1 Query: 130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 G+P G GT +T N ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D G G +MSFGIGAFP G +T NF P + R T Y +Q+ LSK+F +A +W Sbjct: 95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074187) HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48 Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1 Query: 130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 G+P G GT +T N ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D G G +MSFGIGAFP G +T NF P + R T Y +Q+ LSK+F +A +W Sbjct: 95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074185) HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48 Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1 Query: 130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 G+P G GT +T N ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D G G +MSFGIGAFP G +T NF P + R T Y +Q+ LSK+F +A +W Sbjct: 95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Match: CG8974 (gene:FBgn0030693 transcript:FBtr0074189) HSP 1 Score: 166.392 bits (420), Expect = 2.637e-48 Identity = 90/195 (46.15%), Postives = 114/195 (58.46%), Query Frame = 1 Query: 130 GFPSGSGTGPETAGNNSSGS---------FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 G+P G GT +T N ++CNICL+ +KD V+SMCGHLFCWPCLH+W+ T+ +R CPVCKAA+ +DKVIPLYGR+ST Q DPR+K+PPRP GQRTE D G G +MSFGIGAFP G +T NF P + R T Y +Q+ LSK+F +A +W Sbjct: 95 GYPFG-GTDTDTKANEKDKEKEHTADDSLYECNICLDTAKDAVVSMCGHLFCWPCLHQWLLTRPNRKLCPVCKAAVDKDKVIPLYGRNSTHQEDPRNKVPPRPAGQRTEPD----------PVPGFPGFGFGDGFHMSFGIGAFPFGFITSTLNFGEPRPPAAN---RGTRQYEDEQT--LSKLFSYLAVVWILW 273
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310]) HSP 1 Score: 172.17 bits (435), Expect = 2.419e-51 Identity = 90/167 (53.89%), Postives = 108/167 (64.67%), Query Frame = 1 Query: 187 SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 +F+CNICL+ SKD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T ++ +Q LS++FL +A W Sbjct: 38 TFECNICLDTSKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPG---TPQHTDEQ--FLSRLFLFVALLIMFW 190
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:100537822]) HSP 1 Score: 130.954 bits (328), Expect = 9.335e-36 Identity = 74/150 (49.33%), Postives = 86/150 (57.33%), Query Frame = 1 Query: 172 NNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAY 621 + +F+CNICL+ ++D VIS+CGHLFC R CPVCKA ISRDKVIPLYGR S+ Q DPR K PPRPQGQR+E + G DTG +MSFGIGAFP G F T FN NNP F DA+ Sbjct: 39 DRERATFECNICLDTARDAVISLCGHLFC-------------RQQCPVCKAGISRDKVIPLYGRGSSSQEDPRLKTPPRPQGQRSEPESRGPFQGFG-----------DTGFHMSFGIGAFPFGFFTTVFN---TNNP-----FHRADAH 156
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306]) HSP 1 Score: 55.4546 bits (132), Expect = 7.968e-8 Identity = 23/70 (32.86%), Postives = 39/70 (55.71%), Query Frame = 1 Query: 175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRD 384 NS +C ICL+ + VI+ C H+FC PC+ I ++ +A CP+C+A I +++ G + + D Sbjct: 656 NSGSDEECAICLDSLRQPVITYCAHVFCRPCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAETRSD 725
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306]) HSP 1 Score: 55.4546 bits (132), Expect = 8.191e-8 Identity = 23/70 (32.86%), Postives = 39/70 (55.71%), Query Frame = 1 Query: 175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRD 384 NS +C ICL+ + VI+ C H+FC PC+ I ++ +A CP+C+A I +++ G + + D Sbjct: 690 NSGSDEECAICLDSLRQPVITYCAHVFCRPCICEVIRSEKEQAKCPLCRAQIKTKELVEYPGEQAETRSD 759
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310]) HSP 1 Score: 45.4394 bits (106), Expect = 2.848e-6 Identity = 18/24 (75.00%), Postives = 22/24 (91.67%), Query Frame = 1 Query: 187 SFDCNICLEISKDTVISMCGHLFC 258 +F+CNICL+ SKD VIS+CGHLFC Sbjct: 38 TFECNICLDTSKDAVISLCGHLFC 61
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: supt16h (SPT16 homolog, facilitates chromatin remodeling subunit [Source:Xenbase;Acc:XB-GENE-979305]) HSP 1 Score: 162.155 bits (409), Expect = 1.097e-47 Identity = 81/168 (48.21%), Postives = 110/168 (65.48%), Query Frame = 1 Query: 190 FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPG-VDTGVNMSFGIGAFPLGLFATTFNFTGGNN-PQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 ++CNICLE +++ V+S+CGHL+CWPCLH+W+ET+ R CPVCKA ISR+KVIP+YGR ++Q+DPR K PPRPQGQR E + G+ PG DTG +MSFGIGAFP G F T FN ++ P+ D ++ + + S +FL+IA F+W Sbjct: 12 YECNICLETAREPVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVIPIYGRGDSNQKDPRLKTPPRPQGQRPEPENRAGGGV----------PGFTDTGFHMSFGIGAFPFGFFTTVFNTNDLHSAPRADTGLPQSRFFGLPDS-----LFLIIAAFFFLW 164
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: RNF185 (ring finger protein 185 [Source:HGNC Symbol;Acc:HGNC:26783]) HSP 1 Score: 149.443 bits (376), Expect = 1.505e-42 Identity = 89/193 (46.11%), Postives = 114/193 (59.07%), Query Frame = 1 Query: 109 STNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 S S+ G SGS G E + +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISR+KVIPLYGR ST Q DPR+K PPRPQGQR E + G GI +D + SF + A + F+ F+ G P P T Y +Q LS++FL +A W Sbjct: 11 SAENSSPGGASGSTNG-EASSQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISREKVIPLYGRGSTGQEDPREKTPPRPQGQRPEPENRGSQGIKF----------IDGDFSSSFSV-ANCIFTFSICFDVNDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 184
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: HLTF (helicase-like transcription factor [Source:NCBI gene;Acc:394525]) HSP 1 Score: 53.1434 bits (126), Expect = 6.611e-7 Identity = 22/58 (37.93%), Postives = 37/58 (63.79%), Query Frame = 1 Query: 178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348 SSGS +C ICL+ VI+ C H+FC PC+ + I+ + A CP+C+ ++ D+++ Sbjct: 728 SSGSDEECAICLDSLNMPVITYCAHVFCKPCICQVIQHEKQEAKCPLCRGSLRLDQLV 785
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: HLTF (helicase-like transcription factor [Source:NCBI gene;Acc:394525]) HSP 1 Score: 53.1434 bits (126), Expect = 7.038e-7 Identity = 22/58 (37.93%), Postives = 37/58 (63.79%), Query Frame = 1 Query: 178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348 SSGS +C ICL+ VI+ C H+FC PC+ + I+ + A CP+C+ ++ D+++ Sbjct: 735 SSGSDEECAICLDSLNMPVITYCAHVFCKPCICQVIQHEKQEAKCPLCRGSLRLDQLV 792
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Match: chrng (cholinergic receptor, nicotinic gamma [Source:Xenbase;Acc:XB-GENE-990010]) HSP 1 Score: 50.8322 bits (120), Expect = 1.806e-6 Identity = 20/54 (37.04%), Postives = 31/54 (57.41%), Query Frame = 1 Query: 193 DCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPL 354 C +CLE+ + + CGHLFCW C+ W T++ CP+C+ S K++ L Sbjct: 270 KCTLCLEVRRHCTATPCGHLFCWECITEWCNTKTE---CPLCREKFSPQKLVYL 320
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf185 (ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078]) HSP 1 Score: 187.193 bits (474), Expect = 3.518e-57 Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + ST SN+G PSGS G +G S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 9 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf185 (ring finger protein 185 [Source:MGI Symbol;Acc:MGI:1922078]) HSP 1 Score: 185.267 bits (469), Expect = 6.289e-56 Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + ST SN+G PSGS G +G S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 45 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 224
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Rnf5 (ring finger protein 5 [Source:MGI Symbol;Acc:MGI:1860076]) HSP 1 Score: 150.984 bits (380), Expect = 1.821e-43 Identity = 71/141 (50.35%), Postives = 89/141 (63.12%), Query Frame = 1 Query: 142 GSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFN 564 G GP +S +F+CNICLE +++ V+S+CGHL+CWPCLH+W+ET+ R CPVCKA ISR+KV+PLYGR S +DPR K PPRPQGQR + G G G + SFG+GAFP G F T FN Sbjct: 9 GGPEGPNRERGGASATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPF----------GDAGGFHFSFGVGAFPFGFFTTVFN 139
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Brca1 (breast cancer 1, early onset [Source:MGI Symbol;Acc:MGI:104537]) HSP 1 Score: 45.8246 bits (107), Expect = 3.319e-6 Identity = 17/49 (34.69%), Postives = 30/49 (61.22%), Query Frame = 1 Query: 190 FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISR 336 +C ICLE+ K+ V + C H+FC C+ + + + + CP+CK I++ Sbjct: 22 LECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITK 70
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Match: Hltf (helicase-like transcription factor [Source:MGI Symbol;Acc:MGI:1196437]) HSP 1 Score: 50.447 bits (119), Expect = 3.518e-6 Identity = 23/58 (39.66%), Postives = 35/58 (60.34%), Query Frame = 1 Query: 178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVI 348 SSGS +C ICL+ VI+ C H+FC PC+ + I ++ A CP+C+ I D ++ Sbjct: 747 SSGSDEECAICLDSLTFPVITHCAHVFCKPCICQVIHSEQPHAKCPLCRNEIHGDNLL 804
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q91YT2|RN185_MOUSE (E3 ubiquitin-protein ligase RNF185 OS=Mus musculus OX=10090 GN=Rnf185 PE=2 SV=1) HSP 1 Score: 187.193 bits (474), Expect = 2.461e-56 Identity = 102/195 (52.31%), Postives = 122/195 (62.56%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + ST SN+G PSGS G +G S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 9 SASTENSNAGGPSGSSNGTGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q568Y3|RN185_RAT (E3 ubiquitin-protein ligase RNF185 OS=Rattus norvegicus OX=10116 GN=Rnf185 PE=2 SV=1) HSP 1 Score: 175.252 bits (443), Expect = 1.168e-51 Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1 Query: 160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q96GF1|RN185_HUMAN (E3 ubiquitin-protein ligase RNF185 OS=Homo sapiens OX=9606 GN=RNF185 PE=1 SV=1) HSP 1 Score: 175.252 bits (443), Expect = 1.168e-51 Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1 Query: 160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q5RFK9|RN185_PONAB (E3 ubiquitin-protein ligase RNF185 OS=Pongo abelii OX=9601 GN=RNF185 PE=2 SV=1) HSP 1 Score: 174.096 bits (440), Expect = 2.387e-51 Identity = 93/176 (52.84%), Postives = 112/176 (63.64%), Query Frame = 1 Query: 160 ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 29 ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Match: sp|Q5ZIR9|RN185_CHICK (E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus OX=9031 GN=RNF185 PE=2 SV=1) HSP 1 Score: 174.096 bits (440), Expect = 3.424e-51 Identity = 91/171 (53.22%), Postives = 108/171 (63.16%), Query Frame = 1 Query: 175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 N +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 34 NQDNTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 190
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A1W4X226 (E3 ubiquitin-protein ligase RNF185-like OS=Agrilus planipennis OX=224129 GN=LOC108740347 PE=4 SV=1) HSP 1 Score: 184.882 bits (468), Expect = 5.142e-53 Identity = 99/201 (49.25%), Postives = 121/201 (60.20%), Query Frame = 1 Query: 100 MAESTNTSNSGFPSGSGTGPETAGNNSSG--SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV---DTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 MA S N S PS S G G++ +F+CNICL+ +KD V+SMCGHLFCWPCLH+W+ET+ SR CPVCKAAIS+DKVIPLYGR ST+Q+DPR+K+PPRP GQRTE + PG D G +MSFGIGAFP G F +TFNF PN + + LSK+FL +A W Sbjct: 1 MASSKNESE---PSSSKAGVSGEGDDKKEDRTFECNICLDTAKDAVVSMCGHLFCWPCLHQWLETRLSRQVCPVCKAAISKDKVIPLYGRGSTNQQDPREKVPPRPAGQRTEPESGSNF------------PGFGFGDNGFHMSFGIGAFPFGFFTSTFNFG-----DVRPNAAPLGTPQHMEEQFLSKIFLWLAFLFIAW 181
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A087UTJ1 (E3 ubiquitin-protein ligase RNF185 (Fragment) OS=Stegodyphus mimosarum OX=407821 GN=X975_10572 PE=4 SV=1) HSP 1 Score: 184.496 bits (467), Expect = 5.931e-53 Identity = 97/186 (52.15%), Postives = 120/186 (64.52%), Query Frame = 1 Query: 145 SGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV---DTGVNMSFGIGAFPLGLFATTFNFTGGN--NPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 SG G E G+F+CNICL+ +KD V+S+CGHLFCWPCLHRW+ET+ SR CPVCKAAISR+KVIPLYGR ++Q DPR+++PPRP GQRTE + + PG DTG +MSFGIGAFP G+FA++FNF G P P F E +LLSKVFL +A +W Sbjct: 8 SGGGSEET-RTQEGTFECNICLDTAKDAVVSLCGHLFCWPCLHRWLETRPSRQVCPVCKAAISREKVIPLYGRGGSNQ-DPRERLPPRPSGQRTEPENHAGQSF----------PGFGFGDTGFHMSFGIGAFPFGIFASSFNFGDGRPAPPPGTPEFEE--------DQLLSKVFLYVAIAFIVW 173
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A1S3A4N2 (E3 ubiquitin-protein ligase RNF185 isoform X1 OS=Erinaceus europaeus OX=9365 GN=RNF185 PE=4 SV=1) HSP 1 Score: 184.496 bits (467), Expect = 6.421e-53 Identity = 101/195 (51.79%), Postives = 124/195 (63.59%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + S S++G PSG+G G E+ G +S+ F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 9 SASPENSSAGGPSGNGAG-ESGGQDST--FECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 186
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: A0A3M7QLX5 (E3 ubiquitin-ligase RNF185-like OS=Brachionus plicatilis OX=10195 GN=BpHYR1_035672 PE=4 SV=1) HSP 1 Score: 183.726 bits (465), Expect = 1.164e-52 Identity = 91/161 (56.52%), Postives = 114/161 (70.81%), Query Frame = 1 Query: 139 SGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNN----PQNDPNFRE 609 S SG E + +N+S ++CNICLE +KD VISMCGHLFCWPCLH+W+ET+ TCPVCK+AI++DKVIPLYGR+S+++ DPRDKIPPRPQGQRTE+ RN F G+D G+++SFGIGAFP FA+TFNFT N P P + E Sbjct: 9 SKSGKNNENSSDNASSQYECNICLETAKDAVISMCGHLFCWPCLHKWLETKPLNQTCPVCKSAINKDKVIPLYGRNSSNKTDPRDKIPPRPQGQRTEAPRNNFFAS-----------GLD-GLHVSFGIGAFPFSFFASTFNFTTDNRMPAPPPGSPQYAE 157
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Match: H9Z0M5 (RING finger protein 185 isoform 1 OS=Macaca mulatta OX=9544 GN=RNF185 PE=2 SV=1) HSP 1 Score: 183.341 bits (464), Expect = 2.059e-52 Identity = 100/195 (51.28%), Postives = 120/195 (61.54%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + S S +G PSGS G +G S +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR+K PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T Y +Q LS++FL +A W Sbjct: 9 SASPENSTAGSPSGSSNGAGESGGQDS-TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPG---TPQYVDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:406310]) HSP 1 Score: 181.03 bits (458), Expect = 6.357e-55 Identity = 93/186 (50.00%), Postives = 117/186 (62.90%), Query Frame = 1 Query: 139 SGSGTGPETAGNNSS--GSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGV-DTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 + +G+ + +G +SS +F+CNICL+ SKD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR++ PPRPQGQR E + VR G D G MSFGIGAFP G+FAT FN G P P + + LS++FL +A W Sbjct: 18 TATGSSGQASGESSSQDSTFECNICLDTSKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPRERTPPRPQGQRPEPEN------------RGVRFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPGTPQH-----MDEQFLSRLFLFVALVIMFW 186
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:103046714]) HSP 1 Score: 170.244 bits (430), Expect = 8.212e-51 Identity = 91/176 (51.70%), Postives = 106/176 (60.23%), Query Frame = 1 Query: 100 MAESTNTSNSGFPSGSGTGP-ETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYS 624 MA + + G G G E G+ +F+CNICL+ ++D VIS+CGHLFCWPCLH+W+ET+ SR CPVCKA ISRDKVIPLYGR ST Q DPR K PPRPQGQRTE + G DTG +MSFGIGAFP G F T FN NDP R Y+ Sbjct: 1 MAAAAEPRSGGEGHHPGDGDRERDGDGDRAAFECNICLDTARDAVISLCGHLFCWPCLHQWLETRPSRQQCPVCKAGISRDKVIPLYGRGSTSQEDPRLKTPPRPQGQRTEPESRGPFHGFG-----------DTGFHMSFGIGAFPFGFFTTVFN-------TNDPFHRADPHYA 158
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: ENSAMXT00000052741.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000182.1:466606:473602:1 gene:ENSAMXG00000043276.1 transcript:ENSAMXT00000052741.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 51.6026 bits (122), Expect = 8.285e-7 Identity = 27/58 (46.55%), Postives = 36/58 (62.07%), Query Frame = 1 Query: 151 TGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKA 324 T P N +S + C+ICLE+ D V + CGH FC CL ++ ++ SSR CPVCKA Sbjct: 2 TLPNNVQNLTSEAKPCSICLEVFNDPVSTPCGHNFCVVCLRQYWDS-SSRCQCPVCKA 58
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: pex10 (peroxisomal biogenesis factor 10 [Source:NCBI gene;Acc:103034252]) HSP 1 Score: 50.8322 bits (120), Expect = 1.290e-6 Identity = 22/70 (31.43%), Postives = 36/70 (51.43%), Query Frame = 1 Query: 151 TGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYG 360 + P+ + SS + C +CLE + + CGHLFCW C+ W T + CP+C+ +++ L G Sbjct: 257 SSPQAVRSPSSKTSRCILCLEERRHPTTTPCGHLFCWECITEWCNT---KMECPLCREKFQPHRLVYLRG 323
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Match: hltf (helicase-like transcription factor [Source:ZFIN;Acc:ZDB-GENE-030131-3306]) HSP 1 Score: 50.8322 bits (120), Expect = 2.021e-6 Identity = 24/68 (35.29%), Postives = 40/68 (58.82%), Query Frame = 1 Query: 193 DCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDK 396 +C +CL+ + VI+ C H+FC PC+ I+++ A CP+C+A I +++ Y D D R P D+ Sbjct: 731 ECAVCLDSLRQPVITHCAHVFCKPCICEVIQSKQLAAKCPLCRANIKSTELLE-YPGDEEDSR-PTDR 796
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Yeast
Match: IRC20 (E3 ubiquitin ligase and putative helicase; involved in synthesis-dependent strand annealing-mediated homologous recombination; ensures precise end-joining along with Srs2p in the Yku70p/Yku80p/Lig4p-dependent nonhomologous end joining (NHEJ) pathway; localizes to both the mitochondrion and the nucleus; contains a Snf2/Swi2 family ATPase/helicase and a RING finger domain; interacts with Cdc48p and Smt3p; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000004237]) HSP 1 Score: 52.373 bits (124), Expect = 9.982e-8 Identity = 27/87 (31.03%), Postives = 43/87 (49.43%), Query Frame = 1 Query: 175 NSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESD 435 N + C+ICL + I CGH FC C+ W+ S CP+CK S +V ++ST++R+ ++ PR +G + D Sbjct: 1232 NDNQILSCSICLGEVEIGAIIKCGHYFCKSCILTWLRAHSK---CPICKGFCSISEVYNFKFKNSTEKRE-KEIQEPRREGADSSQD 1314
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO37344 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFY7]) HSP 1 Score: 168.318 bits (425), Expect = 1.413e-50 Identity = 86/177 (48.59%), Postives = 114/177 (64.41%), Query Frame = 1 Query: 157 PETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 P N+++ +F+CNICL+ ++D VISMCGHLFCWPCLHRW+ET+ +R+ CPVCKA IS++KVIPL+GR S+ +DPR+K+PPRPQ QRTE + NG G G +SFGIGAFP F+TT GGNNPQ+ + + + LSK+FL +A W Sbjct: 22 PSEDPNSANANFECNICLDTARDAVISMCGHLFCWPCLHRWLETRPNRSMCPVCKAGISKEKVIPLFGRGSSSNQDPREKMPPRPQAQRTEPENNGTFAGFG---------GFGDGFQLSFGIGAFPFAFFSTTL---GGNNPQHP---APPGSPQAEDEQFLSKLFLWVAFLFMFW 183
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO40992 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K6]) HSP 1 Score: 51.6026 bits (122), Expect = 2.337e-7 Identity = 21/72 (29.17%), Postives = 37/72 (51.39%), Query Frame = 1 Query: 157 PETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDST 372 P + G+ C++CLE K + CGHLFCW C+ W ++ CP+C+ + +++ L+ + T Sbjct: 229 PSVVPQSMPGTLKCSLCLENVKHITSTSCGHLFCWHCITEWCSSK-----CPLCREPLQMSRLVYLHHFEPT 295
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Match: EDO30997 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SZ68]) HSP 1 Score: 42.3578 bits (98), Expect = 9.526e-6 Identity = 18/46 (39.13%), Postives = 28/46 (60.87%), Query Frame = 1 Query: 196 CNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAIS 333 C IC E+ + + C H FC C+ W++ +++ CPVCKA+IS Sbjct: 16 CAICKEVLTQPIATPCDHYFCVLCICEWLDQTYNKSGCPVCKASIS 61
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: rnf185 (ring finger protein 185 [Source:NCBI gene;Acc:101167555]) HSP 1 Score: 170.244 bits (430), Expect = 8.516e-51 Identity = 88/167 (52.69%), Postives = 108/167 (64.67%), Query Frame = 1 Query: 187 SFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 +F+CNICL+ +KD VIS+CGHLFCWPCLH+W+ET+ +R CPVCKA ISRDKVIPLYGR ST Q+DPR++ PPRPQGQR E + G D G MSFGIGAFP G+FAT FN G P P T ++ +Q LS++FL +A W Sbjct: 36 TFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPRERTPPRPQGQRPEPENRGGFQGFGF---------GDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAAPG---TPQHTDEQ--FLSRLFLFVALVIMFW 188
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:101175247]) HSP 1 Score: 168.703 bits (426), Expect = 3.718e-50 Identity = 92/181 (50.83%), Postives = 106/181 (58.56%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPE-------TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYS 624 A S GFP+G + +F+CNICL+ ++D VISMCGHLFCWPCLH+W+ETQ SR CPVCKA ISR+KVIPLYGR S+ Q DPR K PPRPQGQRTE + G G DTG +MSFGIGAFP G F T FN NDP F D Y+ Sbjct: 3 AADPRYSRGGFPAGESSNDRDGPGGGSGESERDRATFECNICLDTARDAVISMCGHLFCWPCLHQWLETQPSRQQCPVCKAGISREKVIPLYGRGSSSQEDPRLKTPPRPQGQRTEPESRGGMFQGFG----------DTGFHMSFGIGAFPFGFFTTVFN-------ANDP-FHRADQYA 165
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: RNF5 (ring finger protein 5 [Source:NCBI gene;Acc:101175247]) HSP 1 Score: 131.724 bits (330), Expect = 3.602e-36 Identity = 82/179 (45.81%), Postives = 96/179 (53.63%), Query Frame = 1 Query: 103 AESTNTSNSGFPSGSGTGPE-------TAGNNSSGSFDCNICLEISKDTVISMCGHLFCWP-CLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETD 615 A S GFP+G + +F+CNICL+ ++D VISM +P C +W+ETQ SR CPVCKA ISR+KVIPLYGR S+ Q DPR K PPRPQGQRTE + G G DTG +MSFGIGAFP G F T FN NDP R D Sbjct: 3 AADPRYSRGGFPAGESSNDRDGPGGGSGESERDRATFECNICLDTARDAVISM------YPSCPSQWLETQPSRQQCPVCKAGISREKVIPLYGRGSSSQEDPRLKTPPRPQGQRTEPESRGGMFQGFG----------DTGFHMSFGIGAFPFGFFTTVFN-------ANDPFHRAGD 158
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: rfwd3 (ring finger and WD repeat domain 3 [Source:NCBI gene;Acc:101171660]) HSP 1 Score: 50.447 bits (119), Expect = 2.382e-6 Identity = 23/60 (38.33%), Postives = 32/60 (53.33%), Query Frame = 1 Query: 196 CNICLE---ISKDTVISM--CGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYG 360 C IC E + + +S CGHLF + C+HRW++ Q S A CP C R ++ LY Sbjct: 208 CTICFESWTTAGEHRLSALRCGHLFGYTCIHRWLKAQGSAAKCPQCNKKAKRSDIVLLYA 267
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Match: hltf (helicase like transcription factor [Source:NCBI gene;Acc:101157336]) HSP 1 Score: 49.6766 bits (117), Expect = 4.494e-6 Identity = 19/68 (27.94%), Postives = 40/68 (58.82%), Query Frame = 1 Query: 178 SSGS-FDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQ 378 +SGS +C++CL+ + VI+ C H++C PC+ + I + + CP+C++ I +++ D ++ Sbjct: 788 ASGSDEECSVCLDSIRLPVITHCAHVYCRPCIAQVISNEQEKPRCPLCRSEIKSSELVEFPQEDMEEE 855
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Match: SMESG000060298.1 (SMESG000060298.1) HSP 1 Score: 370.163 bits (949), Expect = 7.448e-129 Identity = 195/196 (99.49%), Postives = 195/196 (99.49%), Query Frame = 1 Query: 100 MAESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRXXXXXXXXXXXXXXVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 687 MAESTNTSNSGFPSGSG GPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRNGFSGIGNIFNGFNVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW Sbjct: 1 MAESTNTSNSGFPSGSGAGPETAGNNSSGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQSSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESDRNGFSGIGNIFNGFNVRPGVDTGVNMSFGIGAFPLGLFATTFNFTGGNNPQNDPNFRETDAYSIQQSELLSKVFLLIAGCCFIW 196
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Match: SMESG000016669.1 (SMESG000016669.1) HSP 1 Score: 111.309 bits (277), Expect = 1.025e-28 Identity = 48/86 (55.81%), Postives = 64/86 (74.42%), Query Frame = 1 Query: 181 SGSFDCNICLEISKDTVISMCGHLFCWPCLHRWIETQ-SSRATCPVCKAAISRDKVIPLYGRDSTDQRDPRDKIPPRPQGQRTESD 435 + + DCNICLE S +V++ CGH+FCWPC+ WIE Q S+ CPVCKA IS DK+IP+YG++S +Q DPR+ IPPRP Q +E + Sbjct: 13 NSNLDCNICLEESTQSVVTYCGHVFCWPCIFTWIEVQNSTENICPVCKAVISVDKLIPIYGQNS-NQIDPRNTIPPRPLAQYSEQN 97 The following BLAST results are available for this feature:
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of E3 ubiquitin-ligase RNF185-like vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of E3 ubiquitin-ligase RNF185-like vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020665 ID=SMED30020665|Name=E3 ubiquitin-ligase RNF185-like|organism=Schmidtea mediterranea sexual|type=transcript|length=1253bpback to top protein sequence of SMED30020665-orf-1 >SMED30020665-orf-1 ID=SMED30020665-orf-1|Name=SMED30020665-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=201bp MAESTNTSNSGFPSGSGTGPETAGNNSSGSFDCNICLEISKDTVISMCGHback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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