Mitochondrial genome maintenance exonuclease 1

Overview
NameMitochondrial genome maintenance exonuclease 1
Smed IDSMED30020640
Length (bp)843
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitochondrial genome maintenance exonuclease 1 (SMED30020640) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitochondrial genome maintenance exonuclease 1 (SMED30020640) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitochondrial genome maintenance exonuclease 1 (SMED30020640) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitochondrial genome maintenance exonuclease 1 (SMED30020640) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020640

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30020640SMESG000050961.1 SmedASXL_008924SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30020640SMESG000050961.1 SmedASXL_008924SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
neoblastSMED30020640SMESG000050961.1 dd_Smed_v4_14245_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Human
Match: MGME1 (mitochondrial genome maintenance exonuclease 1 [Source:HGNC Symbol;Acc:HGNC:16205])

HSP 1 Score: 102.064 bits (253), Expect = 1.552e-24
Identity = 59/207 (28.50%), Postives = 106/207 (51.21%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYL---NSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            N +  VT +L +TM+ Q + +L++W+++ I E+GE   ++Y  ++   G + H   +  L  +E       N    G+ +S Q IL     +   +  V H +L Y G+LD +   +    ++++KT  + +     + T+D+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  +Q W  W  RL +Y E K
Sbjct:  128 NVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPF--IQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKK 332
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Human
Match: MGME1 (mitochondrial genome maintenance exonuclease 1 [Source:HGNC Symbol;Acc:HGNC:16205])

HSP 1 Score: 72.4034 bits (176), Expect = 2.786e-14
Identity = 46/165 (27.88%), Postives = 79/165 (47.88%), Query Frame = 1 
Query:  343 KDIMNIGTQVHRIFDQYLEDKEIPYL---NSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            +D+   G + H   +  L  +E       N    G+ +S Q IL     +   +  V H +L Y G+LD +   +    ++++KT  + +     + T+D+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  +Q W  W  RL +Y E K
Sbjct:   90 QDVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPF--IQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKK 252
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Celegans
Match: C27H6.9 (Mitochondrial genome maintenance exonuclease 1 [Source:UniProtKB/TrEMBL;Acc:A9QY30])

HSP 1 Score: 60.8474 bits (146), Expect = 1.464e-10
Identity = 59/219 (26.94%), Postives = 108/219 (49.32%), Query Frame = 1 
Query:  229 YVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLE----DKEIPYL-----NSCVEGFFKSAQ----EILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPI-------QLAAYIGAYNFG-KPSNEQIIR-GRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYF 819
            +++ IL+  +S Q  L L  W++ KI EMG    +  + + M++GT+ H   ++ L+    + ++  L     N+ +  F KSA     EI      IC  +K V HP+L Y+G  D ++  K+   I+++KT   +   S+F    +D +       QLAAY  A+N   +  N   ++ G L+   +DG PA  + I    + ++ E   ++L +++
Sbjct:   55 FLSAILS-AISDQKALYL--WQKAKIDEMGLSAFKSSMTERMSLGTKTHTKVEEMLKLGHHESKLNNLIDNEKNAAIRNFMKSAMPVILEIQDPQNAIC--EKKVRHPTLAYQGRFDAVVKYKDYWNILDWKT---TPARSSFSTQREDSLSYTSYVRQLAAYASAFNHDVRFENLPFVKQGILVSLKEDGSPAEVYQISEDEMMRTLEEVTEKLNEFW 265
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Zebrafish
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:ZFIN;Acc:ZDB-GENE-041212-68])

HSP 1 Score: 110.923 bits (276), Expect = 4.782e-28
Identity = 63/201 (31.34%), Postives = 104/201 (51.74%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHR----IFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            VT IL +TM P+    L++WR + I E+GE   ++Y  +I   G   H      F Q    KE     + V G+ +S   +L+    +   +  V H +L Y GI+D +   + +  ++++KT  + + +    +TYD+P+Q+AAY GA N     + Q+  G ++ AYKDG PA    ++ K + Q WE W  RL ++ E
Sbjct:  135 VTRILQQTMPPEQAFYLERWRRRMIAELGEEGFKEYSLNIFRQGKLFHAAIENTFTQETVSKEDTECPAEVSGYMESVSHVLTDISGVRAIESAVHHSALQYLGIVDCVAQYRGSLCVIDWKTSEKPKPL--LHNTYDNPLQVAAYTGALNSDNNYSYQVDNGLIVVAYKDGSPAHAHFLNSKQIKQFWEKWLLRLEEFAE 333
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:NCBI gene;Acc:100145685])

HSP 1 Score: 93.2041 bits (230), Expect = 2.612e-21
Identity = 61/203 (30.05%), Postives = 99/203 (48.77%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYL-----EDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIHGKHLNQSWEMWKKRL 807
            VT IL +TM  +    L++W+++ I E+GE    +Y   + + G Q H   +  L       KE P  ++   G+  S Q +L+    +   +  V H  L Y G++D +   +    ++++KT  + +     +DT+D+P+Q+AAYIGA N     N Q+  G ++ AYKDG PA      TD  +H       W  W  RL
Sbjct:  142 VTRILQQTMPMEQAFYLERWKQRMIMELGEQGFAEYTAALFSQGKQFHMQLEDLLLALDHGKKEEPEGST---GYLSSVQHVLTDIIGVKSLESAVHHSELQYLGLVDCVAEYRQKLCVIDWKTSEKPK--PYIRDTFDNPLQIAAYIGAINHDNNYNFQVNCGLIVVAYKDGSPAHTHFMDTDLCLH------FWNKWLLRL 333
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Match: ENSXETT00000009097.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460547.1:59315:64608:-1 gene:ENSXETG00000001147.1 transcript:ENSXETT00000009097.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.7582 bits (125), Expect = 7.746e-8
Identity = 27/70 (38.57%), Postives = 42/70 (60.00%), Query Frame = 1 
Query:  571 IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIH 762
            ++++KT  + +     +DT+D+P+Q+AAYIGA N     N Q+  G ++ AYKDG PA      TD  +H
Sbjct:   92 VIDWKTSEKPKPY--IRDTFDNPLQIAAYIGAINHDNNYNFQVNCGLIVVAYKDGSPAHMHFMDTDLCLH 159
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Match: ENSXETT00000009087.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460547.1:59258:180930:-1 gene:ENSXETG00000001147.1 transcript:ENSXETT00000009087.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 52.7582 bits (125), Expect = 7.746e-8
Identity = 27/70 (38.57%), Postives = 42/70 (60.00%), Query Frame = 1 
Query:  571 IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIH 762
            ++++KT  + +     +DT+D+P+Q+AAYIGA N     N Q+  G ++ AYKDG PA      TD  +H
Sbjct:   92 VIDWKTSEKPKPY--IRDTFDNPLQIAAYIGAINHDNNYNFQVNCGLIVVAYKDGSPAHMHFMDTDLCLH 159
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Match: ENSXETT00000009095.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460547.1:59258:127207:-1 gene:ENSXETG00000001147.1 transcript:ENSXETT00000009095.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 4.041e-7
Identity = 26/70 (37.14%), Postives = 42/70 (60.00%), Query Frame = 1 
Query:  571 IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIH 762
            ++++KT  + +     +DT+D+P+Q+AAYIGA N     + Q+  G ++ AYKDG PA      TD  +H
Sbjct:   92 VIDWKTSEKPKPY--IRDTFDNPLQIAAYIGAINHDNNYHFQVNCGLIVVAYKDGSPAHMHFMDTDLCLH 159
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Match: ENSXETT00000009077.1 (pep primary_assembly:Xenopus_tropicalis_v9.1:KV460547.1:59258:180930:-1 gene:ENSXETG00000001147.1 transcript:ENSXETT00000009077.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 4.041e-7
Identity = 26/70 (37.14%), Postives = 42/70 (60.00%), Query Frame = 1 
Query:  571 IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIH 762
            ++++KT  + +     +DT+D+P+Q+AAYIGA N     + Q+  G ++ AYKDG PA      TD  +H
Sbjct:   92 VIDWKTSEKPKPY--IRDTFDNPLQIAAYIGAINHDNNYHFQVNCGLIVVAYKDGSPAHMHFMDTDLCLH 159
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Mouse
Match: Mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:MGI Symbol;Acc:MGI:1921778])

HSP 1 Score: 106.301 bits (264), Expect = 3.428e-26
Identity = 61/206 (29.61%), Postives = 108/206 (52.43%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVE----GFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            N++  VT IL +TM P+    L++W+E+ + E+GE    +Y  ++   G Q H+  +  L  +E   L    E    G+ +S Q IL+    +   +  V H +L Y G+LD +   +    ++++KT  + + +   ++TYD+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  ++ W  W  RL +Y E
Sbjct:  126 NSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQE--NLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPL--IRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTE 327
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Mouse
Match: Mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:MGI Symbol;Acc:MGI:1921778])

HSP 1 Score: 106.301 bits (264), Expect = 3.428e-26
Identity = 61/206 (29.61%), Postives = 108/206 (52.43%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVE----GFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            N++  VT IL +TM P+    L++W+E+ + E+GE    +Y  ++   G Q H+  +  L  +E   L    E    G+ +S Q IL+    +   +  V H +L Y G+LD +   +    ++++KT  + + +   ++TYD+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  ++ W  W  RL +Y E
Sbjct:  126 NSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQE--NLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPL--IRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTE 327
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Mouse
Match: Mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:MGI Symbol;Acc:MGI:1921778])

HSP 1 Score: 106.301 bits (264), Expect = 3.428e-26
Identity = 61/206 (29.61%), Postives = 108/206 (52.43%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVE----GFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            N++  VT IL +TM P+    L++W+E+ + E+GE    +Y  ++   G Q H+  +  L  +E   L    E    G+ +S Q IL+    +   +  V H +L Y G+LD +   +    ++++KT  + + +   ++TYD+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  ++ W  W  RL +Y E
Sbjct:  126 NSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQE--NLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPL--IRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTE 327
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. UniProt/SwissProt
Match: sp|Q9CXC3|MGME1_MOUSE (Mitochondrial genome maintenance exonuclease 1 OS=Mus musculus OX=10090 GN=Mgme1 PE=2 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 2.398e-25
Identity = 61/206 (29.61%), Postives = 108/206 (52.43%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVE----GFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            N++  VT IL +TM P+    L++W+E+ + E+GE    +Y  ++   G Q H+  +  L  +E   L    E    G+ +S Q IL+    +   +  V H +L Y G+LD +   +    ++++KT  + + +   ++TYD+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  ++ W  W  RL +Y E
Sbjct:  126 NSIPSVTRILQQTMPPEQSFFLERWKERMVLELGEDGFAEYTSNVFLQGKQFHKALESILSPQE--NLTGGEEHPQCGYIESIQHILTEISGVQALESAVQHEALKYVGLLDCVAEYRGKLCVIDWKTSEKPKPL--IRNTYDNPLQVVAYMGAVNHDAHYSFQVQCGLIVVAYKDGSPAHPHFMDEELCSKYWAKWLLRLEEYTE 327
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. UniProt/SwissProt
Match: sp|Q9BQP7|MGME1_HUMAN (Mitochondrial genome maintenance exonuclease 1 OS=Homo sapiens OX=9606 GN=MGME1 PE=1 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 7.454e-24
Identity = 59/207 (28.50%), Postives = 106/207 (51.21%), Query Frame = 1 
Query:  217 NNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYL---NSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            N +  VT +L +TM+ Q + +L++W+++ I E+GE   ++Y  ++   G + H   +  L  +E       N    G+ +S Q IL     +   +  V H +L Y G+LD +   +    ++++KT  + +     + T+D+P+Q+ AY+GA N     + Q+  G ++ AYKDG PA    +  +  +Q W  W  RL +Y E K
Sbjct:  128 NVIPSVTRVLQQTMTKQQVFLLERWKQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPQETLKERDENLLKSGYIESVQHILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPF--IQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKK 332
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. UniProt/SwissProt
Match: sp|F6SDF8|MGME1_XENTR (Mitochondrial genome maintenance exonuclease 1 OS=Xenopus tropicalis OX=8364 GN=mgme1 PE=2 SV=2)

HSP 1 Score: 93.2041 bits (230), Expect = 1.384e-20
Identity = 61/203 (30.05%), Postives = 99/203 (48.77%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYL-----EDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPA------TDFLIHGKHLNQSWEMWKKRL 807
            VT IL +TM  +    L++W+++ I E+GE    +Y   + + G Q H   +  L       KE P  ++   G+  S Q +L+    +   +  V H  L Y G++D +   +    ++++KT  + +     +DT+D+P+Q+AAYIGA N     N Q+  G ++ AYKDG PA      TD  +H       W  W  RL
Sbjct:  142 VTRILQQTMPMEQAFYLERWKQRMIMELGEQGFAEYTAALFSQGKQFHMQLEDLLLALDHGKKEEPEGST---GYLSSVQHVLTDIIGVKSLESAVHHSELQYLGLVDCVAEYRQKLCVIDWKTSEKPK--PYIRDTFDNPLQIAAYIGAINHDNNYNFQVNCGLIVVAYKDGSPAHTHFMDTDLCLH------FWNKWLLRL 333
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Match: A0A4E0RD61 (Mitochondrial genome maintenance exonuclease 1 OS=Fasciola hepatica OX=6192 GN=D915_009492 PE=3 SV=1)

HSP 1 Score: 157.147 bits (396), Expect = 7.452e-43
Identity = 80/214 (37.38%), Postives = 134/214 (62.62%), Query Frame = 1 
Query:  193 FHPNTNDVNNLMY--VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIP-YLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKE--IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIR-GRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKY 816
            F P+   V +  +  V+ IL+KT+SP+S  +L+KW++KK KE+G+    +Y++++  +G +VH +  Q L   E+P  ++  VE + +S + +L   +T+C + + V HP L Y+G LD+++ LK + +  + E+KT +ESRR++  + TYD PIQ+AAY+GAYN  +P   + I+ G L+YAY DGYPA   L+    +   W +W  R+  Y
Sbjct:   51 FLPSCEAVTSQAFPTVSTILSKTISPESAAILQKWQDKKRKELGDAAFAEYLQNMKKLGQRVHSVIQQRLLTGELPKVMDKSVENYCRSVEHLLKHVRTVCVEMQCV-HPELRYRGRLDSVVHLKPDGDHILTEWKTIHESRRITTIERTYDAPIQVAAYLGAYNSIRPPGTKPIKLGMLVYAYADGYPADRILLRPSDVEHFWSIWCDRVHAY 263
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Match: A0A504YSC2 (Mitochondrial genome maintenance exonuclease 1 OS=Fasciola gigantica OX=46835 GN=FGIG_11213 PE=3 SV=1)

HSP 1 Score: 155.606 bits (392), Expect = 2.754e-42
Identity = 80/214 (37.38%), Postives = 133/214 (62.15%), Query Frame = 1 
Query:  193 FHPNTNDVNNLMY--VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIP-YLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKE--IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIR-GRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKY 816
            F P+   V +  +  V+ IL+KT+SP+S  +L+KW++KK KE+G+    +Y++++  +G +VH +  Q L   E+P  ++  VE + +S + +L   +T+C + + V HP L Y+G LD+I+ LK + +  + E+KT +ESRR++  + TYD PIQ+AAY+GAYN  +P   + I+ G L+YAY DGYPA    +    +   W +W  R+  Y
Sbjct:   51 FLPSCEAVTSQAFPTVSTILSKTISPESAAILQKWQDKKRKELGDAAFAEYLQNMKKLGQRVHSVIQQRLLTGELPKVMDKSVENYCRSVEHLLKHVRTVCVEMQCV-HPELQYRGRLDSIVHLKPDGDHILTEWKTIHESRRITTIERTYDAPIQVAAYLGAYNSIRPPGTKPIKLGMLVYAYADGYPADRIFLRPSDVEHFWSIWCDRVHAY 263
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Match: A0A4S2JFG9 (Mitochondrial genome maintenance exonuclease 1 OS=Opisthorchis felineus OX=147828 GN=CRM22_011410 PE=3 SV=1)

HSP 1 Score: 149.443 bits (376), Expect = 6.012e-40
Identity = 82/224 (36.61%), Postives = 133/224 (59.38%), Query Frame = 1 
Query:  166 PISSDKFEQFHPNTNDVNNLMY--VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHR-IFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKE--IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSN-EQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYF 819
            P++ + F    P+ +++  L Y  ++ ILN+TM P+S LVL++W+EKK +EMGE     Y++ I ++G  VH  I  + L       L   V  + +S + IL      C +   + H  L Y+G LD+I++L  ++E  + E+K+ +E++RV++ + TYD P+QLAAY+GAYN  +P   EQI RG L+Y Y DGYPA   ++    L   W++W +R+  Y+
Sbjct:   30 PVTPELF----PSVDNIQTLKYPTISTILNRTMRPESALVLQRWQEKKKREMGEEGFAAYLQGIKSVGRGVHSAIHYRLLNGVFAAELPQEVSNYCQSVRHILDGVTLRCVELDCL-HAELRYRGRLDSIVLLGPSREACVTEWKSVHEAKRVTSIEKTYDAPVQLAAYVGAYNSNRPPGVEQIKRGMLVYVYADGYPADRLVLSPNDLEHYWDVWCQRVEDYY 248
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Match: A0A4S2JIC7 (Mitochondrial genome maintenance exonuclease 1 OS=Opisthorchis felineus OX=147828 GN=CRM22_011410 PE=3 SV=1)

HSP 1 Score: 149.058 bits (375), Expect = 9.506e-40
Identity = 82/224 (36.61%), Postives = 133/224 (59.38%), Query Frame = 1 
Query:  166 PISSDKFEQFHPNTNDVNNLMY--VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHR-IFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKE--IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSN-EQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYF 819
            P++ + F    P+ +++  L Y  ++ ILN+TM P+S LVL++W+EKK +EMGE     Y++ I ++G  VH  I  + L       L   V  + +S + IL      C +   + H  L Y+G LD+I++L  ++E  + E+K+ +E++RV++ + TYD P+QLAAY+GAYN  +P   EQI RG L+Y Y DGYPA   ++    L   W++W +R+  Y+
Sbjct:   36 PVTPELF----PSVDNIQTLKYPTISTILNRTMRPESALVLQRWQEKKKREMGEEGFAAYLQGIKSVGRGVHSAIHYRLLNGVFAAELPQEVSNYCQSVRHILDGVTLRCVELDCL-HAELRYRGRLDSIVLLGPSREACVTEWKSVHEAKRVTSIEKTYDAPVQLAAYVGAYNSNRPPGVEQIKRGMLVYVYADGYPADRLVLSPNDLEHYWDVWCQRVEDYY 254
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Match: A0A074ZHJ3 (Mitochondrial genome maintenance exonuclease 1 OS=Opisthorchis viverrini OX=6198 GN=T265_07338 PE=3 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 1.983e-38
Identity = 82/224 (36.61%), Postives = 131/224 (58.48%), Query Frame = 1 
Query:  166 PISSDKFEQFHPNTNDVNNLMY--VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHR-IFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKE--IVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSN-EQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYF 819
            P++ + F    P+ +++  L Y  ++ ILN+TM P+S LVL KW+EKK +EMGE     Y++ I ++G  VH  I  + L       L   +  + +S + IL      C +   + H  L Y+G LD+I++L  ++E  + E+K+ +E++RV++ +  YD PIQLAAY+GAYN  +P   EQI RG L+Y Y DGYPA   ++    L   W++W +R+  Y+
Sbjct:   30 PVTPELF----PSVDNIQTLKYPTISTILNRTMRPESALVLHKWQEKKKREMGEEGFAAYLQGIKSLGRGVHSAIHYRLLNGVFAAELPREISSYCQSVRHILDGVTLRCVELDCL-HTELRYRGRLDSIVLLGPSQEACVTEWKSVHEAKRVTSIEKAYDAPIQLAAYVGAYNSNRPPGVEQIKRGMLVYVYADGYPADRLVLSPNDLEYYWDVWCQRVEDYY 248
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Cavefish
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:NCBI gene;Acc:103025245])

HSP 1 Score: 120.939 bits (302), Expect = 1.126e-31
Identity = 67/201 (33.33%), Postives = 106/201 (52.74%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSC----VEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE 822
            VT IL  TMSP  +  L++W+ +KI E+GE    +Y +++   G   H   + +L  K  P   +     V G+ +S   +L     +   +  V H +L Y GI+D + + K +  ++++KT    R   +  +TYD+P+Q+AAYIGA N     N Q+  G ++ AYKDG PA    +  K + Q WE W+ RL +Y E
Sbjct:  136 VTRILQNTMSPSQLFYLERWKRRKIAELGEEGFREYSQNLFRQGKLFHAAIESFLTQKSSPKEEAETPDEVSGYLESIGHVLEDVTGVRAIESAVEHQTLRYLGIVDCVAMYKGSLCVIDWKTSE--RPKPSLHNTYDNPLQVAAYIGALNSDDNYNYQVENGLIVVAYKDGSPAHSHYMSEKQVLQYWEKWQFRLEEYME 334
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Sea Lamprey
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:ZFIN;Acc:ZDB-GENE-041212-68])

HSP 1 Score: 75.8702 bits (185), Expect = 2.959e-16
Identity = 51/205 (24.88%), Postives = 99/205 (48.29%), Query Frame = 1 
Query:  214 VNNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDK-EIPYL--NSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNF-GKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKY 816
               L  VT +L  TM       L++   + I E+G+   ++Y   ++  G ++H    + L  +   P +  N  + G+ +S Q +L+    +   +  V H  L Y G +D +   +    ++++KT  + +     +DTYD+P+Q+ AY GA N+    +  Q+ +G ++ AY+DG PA   ++      + W+ W  RL ++
Sbjct:   90 AGGLSSVTRVLQGTMP------LQQRYGRMILELGKEGFDRYSLGVLRQGRKLHAAIQEALTQRLSNPGVDHNELLRGYARSVQPVLADLGRVRAVEGKVQHTRLQYMGHIDCLAEYRGQLCLIDWKTSEKPK--PKLRDTYDNPLQVVAYAGAVNYDANYAPLQVEKGMVVVAYRDGSPAHTHVLDPWLCMEYWQRWLLRLQEF 286
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Nematostella
Match: EDO43044 (Mitochondrial genome maintenance exonuclease 1 [Source:UniProtKB/TrEMBL;Acc:A7RZT1])

HSP 1 Score: 91.6633 bits (226), Expect = 2.147e-22
Identity = 63/199 (31.66%), Postives = 101/199 (50.75%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            VT ILN T  P S+++  KWR+KK  E+GE + ++Y  +I   GT+ H  F + L   +   ++  + G   S   +L    ++   +K VSH SL Y G  D + + +    I+E+KT    R     +D Y+ P+Q+ AY GA N     +  +    ++ AY DG PA    +H  +L    + W+K LVK F ++
Sbjct:   15 VTTILNST-KPLSLIL--KWRDKKKGELGEERFKKYQSEIRKRGTEFHS-FIKNLSSGDGNAISDNINGSLASISSVLKDVTSVIATEKQVSHFSLGYSGYFDMLALFRGVPCIIEWKTSE--RPKPTLQDCYEYPLQVVAYAGAVNSSPYVSVPVTHCAVVIAYHDGSPAH---VHALNLELCEKYWQKWLVKLFNYR 204
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Nematostella
Match: EDO36390 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIS4])

HSP 1 Score: 89.3521 bits (220), Expect = 1.217e-21
Identity = 57/197 (28.93%), Postives = 96/197 (48.73%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIF-DQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESR-RVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKY 816
            VT +L  T     +  L+ W++ +I+E+GE Q +   K+ +  GT  H +  D ++E            G+ KS   +L     I   +  V H +L Y G +D +   K    ++++KT  + + R+SA    +  P+Q+AAY GA N+      QI  G L+ AY+ G PA   ++  +H  + W+ W +RL  Y
Sbjct:    4 VTTVLKHTKPKGELWGLRVWQQSQIEELGEEQFDASKKEALQRGTTFHEVMRDLFVEPSPHGDNTHITSGYLKSVGHVLPEITHISAVESVVVHETLGYAGTVDLVAKYKGTHAVIDWKTSQKPKTRLSA---CHSYPVQVAAYAGAINYDSNYPFQISNGVLVIAYRSGDPADVLIMDREHCLKYWKRWLQRLHLY 197
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Nematostella
Match: EDO28022 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T7M7])

HSP 1 Score: 67.3958 bits (163), Expect = 5.595e-14
Identity = 40/129 (31.01%), Postives = 65/129 (50.39%), Query Frame = 1 
Query:  433 EGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESR-RVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKY 816
             G+ KS   +L     I   +  V H +L Y G +D +   K    ++++KT  + + R+SA    +  P+Q+AAY GA N+      QI  G L+ AY+ G PA   ++  +H  + W+ W +RL  Y
Sbjct:   19 SGYLKSVGHVLPEITHISAVESVVVHETLGYAGTVDLVAKYKGTHAVIDWKTSQKPKTRLSA---CHSYPVQVAAYAGAINYDSNYPFQISNGVLVIAYRSGDPADVLIMDREHCLKYWKRWLQRLHLY 144
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Medaka
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:NCBI gene;Acc:101164998])

HSP 1 Score: 100.138 bits (248), Expect = 4.318e-24
Identity = 57/207 (27.54%), Postives = 103/207 (49.76%), Query Frame = 1 
Query:  232 VTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLED--------KEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            VT IL +T+S + +  L +W+ + + E+GE   +QY + I   G   H   ++ L             P     V+G+ +S   IL   + +   + TV H  L Y G++D +   +    ++++KT  + +      +TYD+P+Q+AAY GA N  +    Q+  G ++ AYKDG PA    +  + +++ W+ W  RL ++ E +
Sbjct:  130 VTRILQQTLSTEQLFYLDRWKRRMVAELGEEGFKQYSQSIFKQGKLFHSALEEILMSGVAWTPGTSGTPEHPPDVQGYLQSISHILEDVRAVRAIESTVQHGPLNYLGVVDCVARYRGVLCVIDWKTSEKPKPF--LSNTYDNPVQVAAYAGALNADENYEYQVENGLIVVAYKDGSPAHAHRLDSELMSEYWKTWLLRLEEFTEQR 334
[Close]
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Planmine SMEST
Match: SMESG000050961.1 (SMESG000050961.1)

HSP 1 Score: 504.597 bits (1298), Expect = 0.000e+0
Identity = 256/260 (98.46%), Postives = 258/260 (99.23%), Query Frame = 1 
Query:   49 MIFKSCYSSILLQSILYTNIKNXXXXXXXXXXXEIIPDFPISSDKFEQFHPNTNDVNNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFEHK 828
            MIFKSCYSSILLQSILYTNIKNSSSLCLSKKLLEIIPDFPISSDKFEQF PNTNDVNNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGE+QLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSH SLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFE+K
Sbjct:    1 MIFKSCYSSILLQSILYTNIKNSSSLCLSKKLLEIIPDFPISSDKFEQFDPNTNDVNNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEVQLEQYIKDIMNIGTQVHRIFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDKTVSHSSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQLAAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWKKRLVKYFENK 260
The following BLAST results are available for this feature:
BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
MGME11.552e-2428.50mitochondrial genome maintenance exonuclease 1 [So... [more]
MGME12.786e-1427.88mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
C27H6.91.464e-1026.94Mitochondrial genome maintenance exonuclease 1 [S... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mgme14.782e-2831.34mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
mgme12.612e-2130.05mitochondrial genome maintenance exonuclease 1 [So... [more]
ENSXETT00000009097.17.746e-838.57pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
ENSXETT00000009087.17.746e-838.57pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
ENSXETT00000009095.14.041e-737.14pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
ENSXETT00000009077.14.041e-737.14pep primary_assembly:Xenopus_tropicalis_v9.1:KV460... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Mgme13.428e-2629.61mitochondrial genome maintenance exonuclease 1 [So... [more]
Mgme13.428e-2629.61mitochondrial genome maintenance exonuclease 1 [So... [more]
Mgme13.428e-2629.61mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|Q9CXC3|MGME1_MOUSE2.398e-2529.61Mitochondrial genome maintenance exonuclease 1 OS=... [more]
sp|Q9BQP7|MGME1_HUMAN7.454e-2428.50Mitochondrial genome maintenance exonuclease 1 OS=... [more]
sp|F6SDF8|MGME1_XENTR1.384e-2030.05Mitochondrial genome maintenance exonuclease 1 OS=... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A4E0RD617.452e-4337.38Mitochondrial genome maintenance exonuclease 1 OS=... [more]
A0A504YSC22.754e-4237.38Mitochondrial genome maintenance exonuclease 1 OS=... [more]
A0A4S2JFG96.012e-4036.61Mitochondrial genome maintenance exonuclease 1 OS=... [more]
A0A4S2JIC79.506e-4036.61Mitochondrial genome maintenance exonuclease 1 OS=... [more]
A0A074ZHJ31.983e-3836.61Mitochondrial genome maintenance exonuclease 1 OS=... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mgme11.126e-3133.33mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mgme12.959e-1624.88mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO430442.147e-2231.66Mitochondrial genome maintenance exonuclease 1 [S... [more]
EDO363901.217e-2128.93Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO280225.595e-1431.01Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mgme14.318e-2427.54mitochondrial genome maintenance exonuclease 1 [So... [more]
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BLAST of Mitochondrial genome maintenance exonuclease 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000050961.10.000e+098.46SMESG000050961.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020640 ID=SMED30020640|Name=Mitochondrial genome maintenance exonuclease 1|organism=Schmidtea mediterranea sexual|type=transcript|length=843bp
ATCTATAAATTTTGAATTATATTTTACAATTTAACTTAATAATTGTCAAT
GATTTTCAAATCATGTTATTCGAGTATTCTACTTCAATCAATTTTATATA
CAAATATAAAAAATAGTTCTTCATTATGTTTATCGAAAAAACTTTTAGAA
ATTATTCCAGATTTTCCTATTTCATCAGATAAATTTGAACAATTTCATCC
AAATACAAATGATGTGAATAATTTGATGTATGTTACACATATTTTAAACA
AGACAATGTCTCCACAATCTATACTAGTGCTCAAAAAATGGCGTGAAAAA
AAAATTAAAGAGATGGGAGAAATCCAACTTGAACAATATATAAAAGATAT
TATGAACATTGGTACTCAAGTTCATAGAATTTTTGATCAATATTTGGAAG
ATAAAGAAATTCCTTACTTAAATTCGTGCGTCGAAGGATTTTTCAAAAGT
GCCCAAGAAATTTTATCGTGTTCACAAACTATTTGTGGAGACGATAAAAC
TGTTTCACATCCATCTTTGTTGTACAAAGGAATTTTGGATAATATAATTG
TACTTAAAAATAACAAAGAAATAGTTGAATTTAAAACGAAAAACGAATCG
AGAAGGGTTTCAGCGTTCAAAGACACATACGATGATCCGATACAATTGGC
AGCTTATATCGGAGCTTATAATTTTGGAAAACCCAGCAACGAGCAAATCA
TTCGTGGTCGATTGATTTATGCTTACAAAGACGGCTATCCGGCCACTGAT
TTTCTAATCCACGGGAAACATTTAAATCAATCTTGGGAAATGTGGAAGAA
AAGGCTGGTCAAATATTTTGAACATAAATAAATATGATTCTGA
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protein sequence of SMED30020640-orf-1

>SMED30020640-orf-1 ID=SMED30020640-orf-1|Name=SMED30020640-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=261bp
MIFKSCYSSILLQSILYTNIKNSSSLCLSKKLLEIIPDFPISSDKFEQFH
PNTNDVNNLMYVTHILNKTMSPQSILVLKKWREKKIKEMGEIQLEQYIKD
IMNIGTQVHRIFDQYLEDKEIPYLNSCVEGFFKSAQEILSCSQTICGDDK
TVSHPSLLYKGILDNIIVLKNNKEIVEFKTKNESRRVSAFKDTYDDPIQL
AAYIGAYNFGKPSNEQIIRGRLIYAYKDGYPATDFLIHGKHLNQSWEMWK
KRLVKYFEHK*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: biological process
TermDefinition
GO:0000002mitochondrial genome maintenance
GO:0006264mitochondrial DNA replication
GO:0043504mitochondrial DNA repair
GO:0090305nucleic acid phosphodiester bond hydrolysis
Vocabulary: molecular function
TermDefinition
GO:0004518nuclease activity
GO:0004527exonuclease activity
GO:0008297single-stranded DNA exodeoxyribonuclease activity
GO:0016787hydrolase activity
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availablePANTHERPTHR31340FAMILY NOT NAMEDcoord: 56..258
NoneNo IPR availablePANTHERPTHR31340:SF3MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1coord: 56..258