COP9 signalosome complex subunit 4

Overview


Name	COP9 signalosome complex subunit 4
Smed ID	SMED30020431
Length (bp)	4663

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of COP9 signalosome complex subunit 4 (SMED30020431) t-SNE clustered cells

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 4 (SMED30020431) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of COP9 signalosome complex subunit 4 (SMED30020431) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for COP9 signalosome complex subunit 4 (SMED30020431) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30020431

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30020431	SMESG000006062.1	dd_Smed_v4_4122_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30020431	SMESG000006062.1	dd_Smed_v4_4122_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30020431	SMESG000006062.1	dd_Smed_v4_4122_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30020431	SMESG000006062.1	Contig43761	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30020431	SMESG000006062.1	Contig43761	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
gamma neoblast	SMED30020431	SMESG000006062.1	dd_Smed_v6_4122_0	dd_Smed_v6	PMID:29674432 Plass et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Match: COPS4 (COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702])

HSP 1 Score: 140.198 bits (352), Expect = 2.790e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Match: COPS4 (COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702])

HSP 1 Score: 140.584 bits (353), Expect = 7.950e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Match: COPS4 (COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702])

HSP 1 Score: 140.198 bits (352), Expect = 1.387e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Match: COPS4 (COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702])

HSP 1 Score: 140.198 bits (352), Expect = 1.703e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Match: COPS4 (COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc:HGNC:16702])

HSP 1 Score: 109.768 bits (273), Expect = 1.599e-25
Identity = 62/151 (41.06%), Postives = 91/151 (60.26%), Query Frame = 1

Query:  484 DEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   30 DYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 179

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Celegans
Match: csn-4 (COP9 signalosome complex subunit 4 [Source:UniProtKB/Swiss-Prot;Acc:Q9N359])

HSP 1 Score: 82.0333 bits (201), Expect = 6.832e-16
Identity = 67/225 (29.78%), Postives = 112/225 (49.78%), Query Frame = 1

Query:  322 ILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAA----VILSGTLIEENQRSMAND-EKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQ-CYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS----ELLLKKVMIE 966
            IL  I  R  ++ ++    R  +A  YE  G   +AA     I S T  + N    A +  K  L ++I +  L C  + +AE Y+NR   L+ ++  +    I +K L A + D K+RF+EA+QR+ ELS  + +  N +K   L KA +  +L    P R +LL+ + KDER     +F ++ KM L +++ + + +     L  + K+    E +LK V+ E
Sbjct:   95 ILAIIKTRTISYEDQVCILRLMLASLYEKEGRIKDAAQALIAINSDTSPKFNGPQAAKEGAKAQLCIRITKLLLDCSEIDEAEQYVNRTSILMVDLGANPDIQIEHKALQARVSDAKRRFVEAAQRYYELSATEQLP-NSDKLTALGKAIVCVLLAKPGPQRSRLLTLIFKDERAPKCASFELIAKMYLTKVIHKDELEEFEHQLQDHQKADEHGESILKGVIQE 318

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Fly
Match: CSN4 (gene:FBgn0027054 transcript:FBtr0301230)

HSP 1 Score: 131.339 bits (329), Expect = 4.610e-32
Identity = 77/204 (37.75%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L K++ R+ +F E+    R ++A  YE    + +AA +L G  +E  Q+  + + KL   LKIA  YL+      AE +INRA  L  E N ++  + YK  YA +LD +++F+EA+QR+ ELS ++ I D  E+   L KA I  +L +A   R ++L+TL KDERC+ LP + ILEKM L R++  S+ +    LL  + K+
Sbjct:   96 LEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELS-YRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKA 298

HSP 2 Score: 53.5286 bits (127), Expect = 1.171e-6
Identity = 28/82 (34.15%), Postives = 39/82 (47.56%), Query Frame = 3

Query: 4269 PFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDW 4514
              + E   S MI+E R+ G IDQ+S  V F +  +                  L  WD +I+ +C+ VN I+EKI  A PDW
Sbjct:  339 AVKAEKIASQMITEGRMNGHIDQISAIVHFENREL------------------LPQWDRQIQSLCYQVNSIIEKISVAEPDW 402

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Fly
Match: CSN4 (gene:FBgn0027054 transcript:FBtr0088859)

HSP 1 Score: 131.339 bits (329), Expect = 4.610e-32
Identity = 77/204 (37.75%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L K++ R+ +F E+    R ++A  YE    + +AA +L G  +E  Q+  + + KL   LKIA  YL+      AE +INRA  L  E N ++  + YK  YA +LD +++F+EA+QR+ ELS ++ I D  E+   L KA I  +L +A   R ++L+TL KDERC+ LP + ILEKM L R++  S+ +    LL  + K+
Sbjct:   96 LEKVNPRVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPLETGQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNSEELQVLYKVCYARVLDYRRKFIEAAQRYNELS-YRKIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHLPAYGILEKMYLERIIRRSELQEFEALLQDHQKA 298

HSP 2 Score: 53.5286 bits (127), Expect = 1.171e-6
Identity = 28/82 (34.15%), Postives = 39/82 (47.56%), Query Frame = 3

Query: 4269 PFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDW 4514
              + E   S MI+E R+ G IDQ+S  V F +  +                  L  WD +I+ +C+ VN I+EKI  A PDW
Sbjct:  339 AVKAEKIASQMITEGRMNGHIDQISAIVHFENREL------------------LPQWDRQIQSLCYQVNSIIEKISVAEPDW 402

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Zebrafish
Match: cops4 (COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) [Source:NCBI gene;Acc:325592])

HSP 1 Score: 140.969 bits (354), Expect = 3.106e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + + +  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKQEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHETERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Zebrafish
Match: cops4 (COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) [Source:NCBI gene;Acc:325592])

HSP 1 Score: 140.969 bits (354), Expect = 3.163e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + + +  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKQEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHETERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Match: hhex (hematopoietically expressed homeobox [Source:Xenbase;Acc:XB-GENE-487159])

HSP 1 Score: 140.969 bits (354), Expect = 2.224e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERMEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLSAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Match: hhex (hematopoietically expressed homeobox [Source:Xenbase;Acc:XB-GENE-487159])

HSP 1 Score: 141.354 bits (355), Expect = 2.522e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   68 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERMEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLSAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 270

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Match: hhex (hematopoietically expressed homeobox [Source:Xenbase;Acc:XB-GENE-487159])

HSP 1 Score: 140.969 bits (354), Expect = 3.052e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERMEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLSAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Match: hhex (hematopoietically expressed homeobox [Source:Xenbase;Acc:XB-GENE-487159])

HSP 1 Score: 140.969 bits (354), Expect = 5.116e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERMEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLSAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Match: hhex (hematopoietically expressed homeobox [Source:Xenbase;Acc:XB-GENE-487159])

HSP 1 Score: 98.5969 bits (244), Expect = 3.722e-21
Identity = 61/154 (39.61%), Postives = 86/154 (55.84%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPS 786
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A  S
Sbjct:   89 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERMEA-LKHALHCTILASAGSS 241

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
Match: Cops4 (COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:MGI:1349414])

HSP 1 Score: 140.584 bits (353), Expect = 1.137e-36
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:    4 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 206

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
Match: Cops4 (COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:MGI:1349414])

HSP 1 Score: 140.198 bits (352), Expect = 1.243e-36
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   38 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 240

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
Match: Cops4 (COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:MGI:1349414])

HSP 1 Score: 140.584 bits (353), Expect = 5.208e-35
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
Match: Cops4 (COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:MGI:1349414])

HSP 1 Score: 115.546 bits (288), Expect = 1.921e-28
Identity = 69/169 (40.83%), Postives = 98/169 (57.99%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCK 831
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+
Sbjct:   38 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQ 205

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q6P0H6|CSN4_DANRE (COP9 signalosome complex subunit 4 OS=Danio rerio OX=7955 GN=cops4 PE=2 SV=1)

HSP 1 Score: 140.969 bits (354), Expect = 2.388e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + + +  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKQEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHETERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q5R648|CSN4_PONAB (COP9 signalosome complex subunit 4 OS=Pongo abelii OX=9601 GN=COPS4 PE=2 SV=1)

HSP 1 Score: 140.969 bits (354), Expect = 2.775e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASVRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Match: sp|O88544|CSN4_MOUSE (COP9 signalosome complex subunit 4 OS=Mus musculus OX=10090 GN=Cops4 PE=1 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 3.643e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Match: sp|A7Y521|CSN4_PIG (COP9 signalosome complex subunit 4 OS=Sus scrofa OX=9823 GN=COPS4 PE=2 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 3.818e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Match: sp|Q4R5E6|CSN4_MACFA (COP9 signalosome complex subunit 4 OS=Macaca fascicularis OX=9541 GN=COPS4 PE=2 SV=1)

HSP 1 Score: 140.584 bits (353), Expect = 3.818e-34
Identity = 80/204 (39.22%), Postives = 119/204 (58.33%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL   LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Match: A0A4U5VB25 (COP9 signalosome complex subunit 4 OS=Collichthys lucidus OX=240159 GN=D9C73_018208 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 3.986e-34
Identity = 82/204 (40.20%), Postives = 123/204 (60.29%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L T+ ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELSYKSIVHESERLEA-LKHALNCTILASAGQQRSRMLATLFKDERCQQLATYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Match: H3D7J9 (COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) OS=Tetraodon nigroviridis OX=99883 PE=4 SV=1)

HSP 1 Score: 147.517 bits (371), Expect = 4.811e-34
Identity = 82/204 (40.20%), Postives = 123/204 (60.29%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L T+ ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELSYKTIVHESERLEA-LKHALNCTILASAGQQRSRMLATLFKDERCQQLATYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Match: A0A3B5KE76 (COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) OS=Takifugu rubripes OX=31033 GN=cops4 PE=4 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 5.437e-34
Identity = 83/204 (40.69%), Postives = 123/204 (60.29%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS ++ I    E+   L  A    IL +A   R ++L+TL KDERC+ L T+ ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELS-YKTIVHETERLEALKHALNCTILASAGQQRSRMLATLFKDERCQQLATYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Match: A0A5C6NI23 (COP9 signalosome complex subunit 4 OS=Takifugu flavidus OX=433684 GN=D4764_20G0003010 PE=4 SV=1)

HSP 1 Score: 147.132 bits (370), Expect = 5.437e-34
Identity = 83/204 (40.69%), Postives = 123/204 (60.29%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS ++ I    E+   L  A    IL +A   R ++L+TL KDERC+ L T+ ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELS-YKTIVHETERLEALKHALNCTILASAGQQRSRMLATLFKDERCQQLATYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Match: A0A0S7HJX3 (CSN4 (Fragment) OS=Poeciliopsis prolifica OX=188132 GN=CSN4 PE=4 SV=1)

HSP 1 Score: 145.206 bits (365), Expect = 1.195e-33
Identity = 81/204 (39.71%), Postives = 122/204 (59.80%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:  126 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELSYKSIVHESERLEA-LKHALNCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 328

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Cavefish
Match: cops4 (COP9 signalosome subunit 4 [Source:NCBI gene;Acc:103038815])

HSP 1 Score: 140.969 bits (354), Expect = 2.732e-35
Identity = 80/204 (39.22%), Postives = 120/204 (58.82%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHESERLEA-LKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

HSP 2 Score: 53.9138 bits (128), Expect = 1.021e-6
Identity = 29/91 (31.87%), Postives = 44/91 (48.35%), Query Frame = 3

Query: 4248 IEFPVMFPFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSP 4520
            +E P   P + E   S MI+E R+ G IDQ+ G V F +                   + L +WD +I+ +C  VN ++EKI  A P+W+ 
Sbjct:  328 LEIP---PAKAEKIASQMITEGRMNGFIDQIDGIVHFET------------------REPLPTWDKQIQSLCFQVNNLLEKISQAAPEWTA 397

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Cavefish
Match: cops4 (COP9 signalosome subunit 4 [Source:NCBI gene;Acc:103038815])

HSP 1 Score: 98.2117 bits (243), Expect = 2.255e-21
Identity = 61/154 (39.61%), Postives = 87/154 (56.49%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPS 786
            L KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE   +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + +++  E  L  A    IL +A  S
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKSIVHESERLEA-LKHALHCTILASAGSS 241

HSP 2 Score: 53.5286 bits (127), Expect = 9.185e-7
Identity = 29/90 (32.22%), Postives = 44/90 (48.89%), Query Frame = 3

Query: 4248 IEFPVMFPFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWS 4517
            +E P   P + E   S MI+E R+ G IDQ+ G V F +                   + L +WD +I+ +C  VN ++EKI  A P+W+
Sbjct:  271 LEIP---PAKAEKIASQMITEGRMNGFIDQIDGIVHFET------------------REPLPTWDKQIQSLCFQVNNLLEKISQAAPEWT 339

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001209.1 (pep scaffold:Pmarinus_7.0:GL478826:34518:39563:1 gene:ENSPMAG00000001075.1 transcript:ENSPMAT00000001209.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 132.88 bits (333), Expect = 3.481e-33
Identity = 78/207 (37.68%), Postives = 115/207 (55.56%), Query Frame = 1

Query:  316 NKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            +  L+KI  R+ +F E+    R+++A  YE   D+ NAA +L G  +E  Q+  + D KL   LKIA  YL+      AE++INRA  L NE       IHYK  YA +LD +++F+EA+QR+ ELS    + + +E+   L  A    IL +A   R ++L+TL KDERC+ L    ILEKM L+R++           L P+ K+
Sbjct:   92 HHALDKIQPRVISFEEQVASIRQHVASIYEREQDWRNAAQVLVGIPLETGQKHYSTDYKLETYLKIARLYLEDDDPVQAEAFINRASLLQNESASPLLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKPLVAE-EERLQALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAHGILEKMYLDRIIRSGQLHEFSAELAPHQKA 297

HSP 2 Score: 55.0694 bits (131), Expect = 8.910e-8
Identity = 28/94 (29.79%), Postives = 44/94 (46.81%), Query Frame = 3

Query: 4236 IFVYIEFPVMFPFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWS 4517
            +   +E P   P + E   S MI+E R+ G +DQ+ G V F S                   + L +WD +I+ +C  VN ++EKI    P+W+
Sbjct:  330 LGALLEIP---PEKAEKIASQMITEGRMAGVVDQIDGIVHFES------------------REPLPTWDKQIQSLCFQVNTLLEKITQHAPEWT 402

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Medaka
Match: cops4 (COP9 signalosome subunit 4 [Source:NCBI gene;Acc:101172094])

HSP 1 Score: 145.591 bits (366), Expect = 8.393e-37
Identity = 81/204 (39.71%), Postives = 121/204 (59.31%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKS 936
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + + +  E  L  A    IL +A   R ++L+TL KDERC+ L  + ILEKM L+R++  +  +    +L+P+ K+
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELSYKSIVHETERLEA-LKHALNCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKA 291

HSP 2 Score: 54.299 bits (129), Expect = 6.517e-7
Identity = 29/91 (31.87%), Postives = 44/91 (48.35%), Query Frame = 3

Query: 4248 IEFPVMFPFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSP 4520
            +E P   P + E   S MI+E R+ G IDQ+ G V F +                   + L +WD +I+ +C  VN ++EKI  A P+W+ 
Sbjct:  328 LEIP---PAKAEKIASQMITEGRMNGFIDQIDGIVHFET------------------REPLPTWDKQIQSLCFQVNNLLEKIRQAAPEWAA 397

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Medaka
Match: cops4 (COP9 signalosome subunit 4 [Source:NCBI gene;Acc:101172094])

HSP 1 Score: 102.449 bits (254), Expect = 9.775e-23
Identity = 62/154 (40.26%), Postives = 88/154 (57.14%), Query Frame = 1

Query:  325 LNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPS 786
            L KI  R+ +F E+    R+++A  YE  GD+ NAA +L G  +E  Q+    D KL+  LKIA  YL+      AE+YINRA  L NE + +Q  IHYK  YA +LD +++F+EA+QR+ ELS    + + +  E  L  A    IL +A  S
Sbjct:   89 LEKIQPRVISFEEQVASIRQHLATIYEKEGDWRNAAQVLVGIPLETGQKQYNVDYKLDTYLKIARLYLEDDDPVQAEAYINRASLLQNESSNEQLQIHYKVCYARVLDFRRKFIEAAQRYNELSYKSIVHETERLEA-LKHALNCTILASAGSS 241

HSP 2 Score: 54.299 bits (129), Expect = 6.197e-7
Identity = 29/90 (32.22%), Postives = 44/90 (48.89%), Query Frame = 3

Query: 4248 IEFPVMFPFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWS 4517
            +E P   P + E   S MI+E R+ G IDQ+ G V F +                   + L +WD +I+ +C  VN ++EKI  A P+W+
Sbjct:  271 LEIP---PAKAEKIASQMITEGRMNGFIDQIDGIVHFET------------------REPLPTWDKQIQSLCFQVNNLLEKIRQAAPEWA 339

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST
Match: SMESG000006062.1 (SMESG000006062.1)

HSP 1 Score: 519.235 bits (1336), Expect = 7.792e-172
Identity = 277/278 (99.64%), Postives = 277/278 (99.64%), Query Frame = 1

Query:  220 DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIEXXXXXXXXXXXXXXXXXASQLLKISPNDV 1053
            DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIESNISSISHVYSSISLESASQLLKISPND 
Sbjct:   73 DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIESNISSISHVYSSISLESASQLLKISPNDT 350

HSP 2 Score: 106.686 bits (265), Expect = 7.792e-172
Identity = 69/69 (100.00%), Postives = 69/69 (100.00%), Query Frame = 2

Query:   11 MYRHYNDYXXXXXXXXXXXXXXXDIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH 217
            MYRHYNDYNSTLPNMNNNNSNCSDIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH
Sbjct:    1 MYRHYNDYNSTLPNMNNNNSNCSDIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH 69

HSP 3 Score: 154.451 bits (389), Expect = 7.086e-40
Identity = 76/97 (78.35%), Postives = 77/97 (79.38%), Query Frame = 3

Query: 4269 PFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN 4559
            P  TENFISSMISEDRLVGTIDQMSGYVRFP                  +YKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN
Sbjct:  347 PNDTENFISSMISEDRLVGTIDQMSGYVRFP------------------KYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN 425

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST
Match: SMESG000006062.1 (SMESG000006062.1)

HSP 1 Score: 519.62 bits (1337), Expect = 7.971e-171
Identity = 277/278 (99.64%), Postives = 277/278 (99.64%), Query Frame = 1

Query:  220 DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIEXXXXXXXXXXXXXXXXXASQLLKISPNDV 1053
            DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIESNISSISHVYSSISLESASQLLKISPND 
Sbjct:   59 DTSLSLTPLFVRVSVNYCVVYKDKFVEVIESLNKILNKISNRLQTFREETIKCRENIAKCYEDIGDFSNAAVILSGTLIEENQRSMANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYKRLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTAASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLPYHKSELLLKKVMIESNISSISHVYSSISLESASQLLKISPNDT 336

HSP 2 Score: 154.836 bits (390), Expect = 4.520e-40
Identity = 76/97 (78.35%), Postives = 77/97 (79.38%), Query Frame = 3

Query: 4269 PFQTENFISSMISEDRLVGTIDQMSGYVRFPSIPIA*DFLFAYNFL*YSEYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN 4559
            P  TENFISSMISEDRLVGTIDQMSGYVRFP                  +YKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN
Sbjct:  333 PNDTENFISSMISEDRLVGTIDQMSGYVRFP------------------KYKSLASWDSKIEWICHSVNCIVEKIENAYPDWSPGKNDISRAKAEIN 411

HSP 3 Score: 94.7449 bits (234), Expect = 6.095e-20
Identity = 46/46 (100.00%), Postives = 46/46 (100.00%), Query Frame = 2

Query:   80 DIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH 217
            DIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH
Sbjct:   10 DIEILELIYNFNEIKDHVNSIEEFLDKINNSYEACTPSVVYRIIEH 55

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST
Match: SMESG000014261.1 (SMESG000014261.1)

HSP 1 Score: 67.3958 bits (163), Expect = 5.063e-11
Identity = 35/61 (57.38%), Postives = 41/61 (67.21%), Query Frame = -1

Query: 2771 GHSTVWFDDNLKYG*SEPTETFNNPTICRNCN-------------*SNNKFPTVTNHSKSK 2914
            GHS +WF+D LKYG SEPTETFNNPT+C +CN              SNNK  TV+NHSKS+
Sbjct:  437 GHSAIWFEDTLKYGRSEPTETFNNPTLCGDCNDVDRTNAENTINLLSNNKSSTVSNHSKSE 497

[Close]

BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST
Match: SMESG000014261.1 (SMESG000014261.1)

HSP 1 Score: 67.3958 bits (163), Expect = 6.300e-11
Identity = 35/61 (57.38%), Postives = 41/61 (67.21%), Query Frame = -1

Query: 2771 GHSTVWFDDNLKYG*SEPTETFNNPTICRNCN-------------*SNNKFPTVTNHSKSK 2914
            GHS +WF+D LKYG SEPTETFNNPT+C +CN              SNNK  TV+NHSKS+
Sbjct:  468 GHSAIWFEDTLKYGRSEPTETFNNPTLCGDCNDVDRTNAENTINLLSNNKSSTVSNHSKSE 528

The following BLAST results are available for this feature:

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Celegans
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Fly
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Zebrafish
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Cavefish
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Sea Lamprey
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Yeast
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Nematostella
BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Medaka
BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
COPS4	2.790e-35	39.22	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc...	[more]
COPS4	7.950e-35	39.22	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc...	[more]
COPS4	1.387e-34	39.22	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc...	[more]
COPS4	1.703e-34	39.22	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc...	[more]
COPS4	1.599e-25	41.06	COP9 signalosome subunit 4 [Source:HGNC Symbol;Acc...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1


Match Name	E-value	Identity	Description
csn-4	6.832e-16	29.78	COP9 signalosome complex subunit 4 [Source:UniPro...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
CSN4	4.610e-32	37.75	gene:FBgn0027054 transcript:FBtr0301230	[more]
CSN4	4.610e-32	37.75	gene:FBgn0027054 transcript:FBtr0088859	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cops4	3.106e-35	39.22	COP9 constitutive photomorphogenic homolog subunit...	[more]
cops4	3.163e-35	39.22	COP9 constitutive photomorphogenic homolog subunit...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hhex	2.224e-35	39.22	hematopoietically expressed homeobox [Source:Xenba...	[more]
hhex	2.522e-35	39.22	hematopoietically expressed homeobox [Source:Xenba...	[more]
hhex	3.052e-35	39.22	hematopoietically expressed homeobox [Source:Xenba...	[more]
hhex	5.116e-35	39.22	hematopoietically expressed homeobox [Source:Xenba...	[more]
hhex	3.722e-21	39.61	hematopoietically expressed homeobox [Source:Xenba...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4


Match Name	E-value	Identity	Description
Cops4	1.137e-36	39.22	COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:...	[more]
Cops4	1.243e-36	39.22	COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:...	[more]
Cops4	5.208e-35	39.22	COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:...	[more]
Cops4	1.921e-28	40.83	COP9 signalosome subunit 4 [Source:MGI Symbol;Acc:...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q6P0H6\|CSN4_DANRE	2.388e-34	39.22	COP9 signalosome complex subunit 4 OS=Danio rerio ...	[more]
sp\|Q5R648\|CSN4_PONAB	2.775e-34	39.22	COP9 signalosome complex subunit 4 OS=Pongo abelii...	[more]
sp\|O88544\|CSN4_MOUSE	3.643e-34	39.22	COP9 signalosome complex subunit 4 OS=Mus musculus...	[more]
sp\|A7Y521\|CSN4_PIG	3.818e-34	39.22	COP9 signalosome complex subunit 4 OS=Sus scrofa O...	[more]
sp\|Q4R5E6\|CSN4_MACFA	3.818e-34	39.22	COP9 signalosome complex subunit 4 OS=Macaca fasci...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A4U5VB25	3.986e-34	40.20	COP9 signalosome complex subunit 4 OS=Collichthys ...	[more]
H3D7J9	4.811e-34	40.20	COP9 constitutive photomorphogenic homolog subunit...	[more]
A0A3B5KE76	5.437e-34	40.69	COP9 constitutive photomorphogenic homolog subunit...	[more]
A0A5C6NI23	5.437e-34	40.69	COP9 signalosome complex subunit 4 OS=Takifugu fla...	[more]
A0A0S7HJX3	1.195e-33	39.71	CSN4 (Fragment) OS=Poeciliopsis prolifica OX=18813...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cops4	2.732e-35	39.22	COP9 signalosome subunit 4 [Source:NCBI gene;Acc:1...	[more]
cops4	2.255e-21	39.61	COP9 signalosome subunit 4 [Source:NCBI gene;Acc:1...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000001209.1	3.481e-33	37.68	pep scaffold:Pmarinus_7.0:GL478826:34518:39563:1 g...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of COP9 signalosome complex subunit 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2


Match Name	E-value	Identity	Description
cops4	8.393e-37	39.71	COP9 signalosome subunit 4 [Source:NCBI gene;Acc:1...	[more]
cops4	9.775e-23	40.26	COP9 signalosome subunit 4 [Source:NCBI gene;Acc:1...	[more]

BLAST of COP9 signalosome complex subunit 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000006062.1	7.792e-172	99.64	SMESG000006062.1	[more]
SMESG000006062.1	7.971e-171	99.64	SMESG000006062.1	[more]
SMESG000014261.1	5.063e-11	57.38	SMESG000014261.1	[more]
SMESG000014261.1	6.300e-11	57.38	SMESG000014261.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30020431 ID=SMED30020431|Name=COP9 signalosome complex subunit 4|organism=Schmidtea mediterranea sexual|type=transcript|length=4663bp
TTTAATTTAAATGTACCGCCATTATAACGATTATAATTCAACATTGCCGA
ATATGAATAATAATAATTCTAATTGTAGTGATATAGAAATTTTAGAATTG
ATATATAATTTTAACGAAATTAAAGACCATGTAAATTCAATTGAAGAGTT
TCTTGATAAAATTAATAATTCATATGAAGCTTGTACTCCTTCTGTGGTGT
ATCGAATCATTGAACATATGATACGTCGCTCAGTCTAACTCCATTATTTG
TTCGAGTTTCTGTAAATTATTGTGTTGTGTACAAAGATAAATTTGTTGAA
GTTATTGAATCATTAAATAAAATTTTGAACAAAATCTCCAACCGGCTACA
AACATTTAGAGAAGAGACAATAAAATGTCGAGAAAATATAGCTAAATGCT
ATGAAGACATTGGCGATTTCTCAAATGCTGCTGTTATACTGAGTGGGACA
CTTATTGAAGAGAATCAAAGATCAATGGCTAATGATGAAAAATTGAATTT
AAATTTAAAAATAGCTGAATATTATTTGAAGTGCTATTCCGTTAAAGATG
CCGAGTCATATATAAATCGAGCCTGTCAGTTACTTAACGAAGTTAACAAG
GATCAATGTTATATTCACTATAAAAGATTGTATGCTGAAATGTTGGATAT
GAAACAGAGATTTCTCGAGGCATCTCAACGATTCATGGAACTTTCGTTGC
ATCAGTTTATCACGGATAATAAAGAAAAAGAAGTGTATCTAATAAAAGCA
ACTATATCAGCAATATTAACTGCAGCGTCTCCCAGTCGATTTAAATTGTT
ATCTACACTTTGTAAAGACGAAAGATGTAAAAGCTTGCCTACGTTTAGTA
TATTAGAAAAAATGTCTCTCAATCGATTGGTCGACGAGAGCGATTTCAAG
GGAATAATGGATCTGTTATTACCATATCACAAAAGCGAATTGCTCCTGAA
AAAGGTTATGATAGAAAGCAATATCTCATCAATTAGTCATGTCTATTCAT
CGATTAGCCTCGAAAGCGCATCGCAATTGCTGAAAATATCTCCTAATGAT
GTTAGTTAGATTTGACTATTTAATATTATTTTATATTAGTAAGAGAGGGG
CGCTTTGTCTTCTGGGAACGCATTAAAATTCCCTTTGTAAAATCCCCCCC
ACTATACAACAATAGCATTAATTTCCGTTATACTATCTCTAATATTTCAT
AACTGTTTTATGGGAGATTCTCAAGCAGTTGAGAACATTTTCAAATATAT
TTAAATGGAGAAAGATAAATCTTTGATTCCTGTAGCTAGGGAAAATGGGG
CCTCAAATTATCGAGCTTCCAGTTGTGTTGGGTCTCGGTTGGAAGGTTTT
TGCAAATTTTCAATTTATAGTGAAATAATCAATATTTTCATATCATTGAA
TTTAGTGTATTTCTCTATATCAGGGTTTCTTAATCTTTTACACTTCGTTA
CTTTAAAATTGAATTATTGTCCCTCCTCGCTCAGAAGATATTTTTTCGGG
GAGGAACATTTAATCGGTGACAAGTCTCTGCTCTTTGTAGTGTTGACTTT
TTGGAGTTCATGTTGCTATTTATAGACGTAAGGGTCGCCCATATATTGCG
TACGCACTGGGGAGAGCGTGAGGGAGTCATGACAGAGTGTGTGCGTTACG
CATGCACATATTCTATTACTTTGAAATTCGGACGGTTCCTAAATAGCCAA
CCGCATCATTATTCCGTATTTAAAGATGGATTTTAAGAAAACGTGAAAGA
TATGAATTGAATTAATTATAAATGCAACTAAAATTCTGGATTTTAAATTG
GTTTACTAATTGATATATTACTATAACCAGAAAGTGCACACAAAACGGAA
CCAACGAATGCTCGGAATAATTTGTTTGATTATTGGCATGGATTAAAAAT
AATATATTCAAGAAGATACCTAGATGACTTGCTAAAGAGGGAAAGTTTAT
ATTTTGGAGATGTTCCCGTAGTTGAAAGTGTTGTTATTGATTGCATAGAT
ATTTTCATTTATTTGGAGGCCGGTGGGATTGGGATCTTTTGTTTCTATAA
CTTCTTTCATGAAAAAGCTTTTAACTTGCAAAATTTGTCTTCGTTCATTC
TCGCGATTAATATTTAAATCCCGACATCCAAAACACAAACGAAACACATG
GACTATTGCTGATCTTGAAGTTAAATTCCAGAAAATAAAGCAGCAACATA
TCCACAGATTATTTTCTCGGGCCCGCAACACCAGGCATAATATCCATTTT
TATATTAGAGTCGATAATTGATTTCATAATTAATATTTTTATTGTAAACC
TATAAATAGCCTTCCAAGAAGTATTATTTATTTTTTTAAACTAATATTTA
TATTTTATAATTAGCAAGACTGACTGTACATTGCTCACGTAAAAATCAAA
TCTTCAAATAAATTAATCGGTTTGCAAAAATGATTATAAAAGTTTGCAAA
CTGAATCGGTTACTTTAATCCCAGAATCTTGAAAATAATTAATAACAAAA
TAAAATCCCTTGATATTAAGAATAACCAAAAAACACCTGATTATAGTCAG
AAAATGCACTTTGTCGAATTCGCCCTCTAAAATCAATAATTACATTTTTG
TGGTGCAAAAAACTTCAGTTCTTCTGACTTTTTTGAAAACCAAAAAACAC
TTCTGAATAGTCAGAAATTGAGCTTTGCACTTCAAAATCAATAATACTGG
CTACTTTCTAATTACTTTAATTATAAAACTTCAAAGCAATTAATAACAAA
ATTCTTTGTTTGTTGAATGTTTTACTTTTGGAGTGATTAGTGACTGTAGG
GAATTTATTGTTAGATTAATTGCAATTTCTACAAATTGTAGGATTGTTAA
ATGTTTCTGTCGGTTCACTTCAACCGTATTTCAAATTGTCATCAAACCAA
ACAGTACTATGGCCAATTTACTGATCACTGCAATTATCATTATAACAGTT
GCCCCGGGTAAATTCACTTCACGACATATTGAATTTGGAATTACTTTCAA
TTTTAAATCCTTTAATTTTTTTTCAAATCTTTTACAAGTTCTTTTGATTT
CGAACTTTTTTATTACGAATTTAGTAGTTATTACTAAAATACGTAGAAAC
TATTCCAACTAGGAATCAAATGATCAACTGTTTAATTTTTTGTACAAATC
AATACCAAAAAGAAATTGATTTTTGCGAATCCGGGATATATTAACAAAAA
CAGACGAAAATAAGAAACAAACATTAAAACCCTTTTTCTTGTTTTGTGCT
ATTCCTTATGATTTTTTATTTTTAAAAAATTTCTGTGTTTGGTAAAAAAG
ACCGTTACAATGGGGTTAAAAATCTAAAATCATTTTAAACGATTTGAAGT
AGGTAACAATTAGAATTGAATTGTGTAGAAATGCGAAAAAGAAGAAAATC
AACCAATTATTAAATTTGAATTTGTAAAACTGGTCAGATATCGATTAGAC
AATGGTGAAGATCATGATGATAATGAATTTATCGGTATAAACGGTCGGAT
AGCAAGTGAATGTATAAAAACCTGAGTTAGGTAAACAACAACAAAAATTA
AACAAGAGGGAATTCAAAAGGCCATTATCAGGATAGCATGATTGATGGGA
AGATGTGGGAAAATATCATCATTAGGAAAGGGAACGGTAGAGTACTTAAT
TATACTGTTGTACTTCGAGATCATGAAAGTAAGCTGTATAAAGAAGATTG
TCAAACAGAAGAAATTTGGGTCGAGAATAATCAATCAAATGGATCATACT
ACTATATAAAGAAAGTAGAAATTAGAAACAGCCGGCATTTCGCCTTAGGT
AGAAACGAAGAATAAGAGAATATAAATTTGGTATAAATACAATCTATTAG
AAGTAGGACACAACAGAAAAGTTGTCAAAGGAATTCGTAGAGCAGTCAGA
GTCCAAGCAGGATCAGATTATTGATTTGGTGTGTAATAATTTGTGATAAA
TAGTTGCAAATACAAATATATATTGGGAGTATTGGGTTTTAATTTATAGA
GCGCATGGAGTCAGAACTACCGGCTATTATCATTTCATTGATTAAAGCCC
AATAGTTAGATTTGTATGAATAAAGTAACCTGAATGTGATTCCAATACAC
ATTTCCAGCTGGCTATATGAGAATCGGTGTTCAAAATTTATGATCGTGGA
AAAACTCAAAAACTATGACATTATCTTGATTCTTGTCGCGCTTTTATTGG
CGGGTACCCAAAAAGATCCGAATTATAATTTATCGATTTTTGTTTATATA
GAATTTCCCGTCATGTTTCCATTCCAGACTGAGAATTTTATTTCCTCAAT
GATATCGGAGGATAGACTGGTAGGCACAATCGATCAAATGTCCGGTTACG
TAAGATTTCCTAGTATTCCTATTGCTTAGGATTTTCTATTTGCTTATAAT
TTCCTTTGATATTCAGAGTATAAATCACTGGCATCGTGGGACAGCAAAAT
CGAATGGATTTGTCATTCGGTCAATTGTATTGTGGAGAAAATAGAAAATG
CCTATCCGGATTGGTCGCCGGGAAAAAATGATATTTCTCGTGCCAAGGCT
GAGATTAATTAATAATATTGAATTAAATTGCTTTTATTTCGTTTCGTTTT
TTATGCTCGTTTGATTTATTAAATTTTTATTTATTAAATGCATAGCGATT
GAGAAAGTTATTC

protein sequence of SMED30020431-orf-1

>SMED30020431-orf-1 ID=SMED30020431-orf-1|Name=SMED30020431-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=195bp
MANDEKLNLNLKIAEYYLKCYSVKDAESYINRACQLLNEVNKDQCYIHYK
RLYAEMLDMKQRFLEASQRFMELSLHQFITDNKEKEVYLIKATISAILTA
ASPSRFKLLSTLCKDERCKSLPTFSILEKMSLNRLVDESDFKGIMDLLLP
YHKSELLLKKVMIESNISSISHVYSSISLESASQLLKISPNDVS*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000039	gamma neoblast
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR036388	WH-like_DNA-bd_sf
IPR037754	CSN4
IPR040134	PSMD12/CSN4
IPR000717	PCI_dom
IPR011991	WHTH_DNA-bd_dom
IPR011990	TPR-like_helical_dom_sf

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding

Vocabulary: **biological process**
Term	Definition
GO:0000338	protein deneddylation

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0008180	COP9 signalosome
GO:0030054	cell junction
GO:0031410	cytoplasmic vesicle
GO:0045202	synapse

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR036388	Winged helix-like DNA-binding domain superfamily	GENE3D	G3DSA:1.10.10.10		coord: 151..194 e-value: 4.0E-5 score: 25.1
IPR037754	COP9 signalosome complex subunit 4	PANTHER	PTHR10855:SF2	COP9 SIGNALOSOME COMPLEX SUBUNIT 4	coord: 3..193
IPR040134	26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4	PANTHER	PTHR10855	26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4	coord: 3..193

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COP9 signalosome complex subunit 4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Owlery

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