Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

Overview


Name	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase
Smed ID	SMED30020430
Length (bp)	1560

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (SMED30020430) t-SNE clustered cells

Violin plots show distribution of expression levels for Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (SMED30020430) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (SMED30020430) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30020430

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 4

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30020430	SMESG000034959.1	dd_Smed_v4_3998_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30020430	SMESG000034959.1	dd_Smed_v4_3998_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30020430	SMESG000034959.1	dd_Smed_v4_3998_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30020430	SMESG000034959.1	dd_Smed_v4_3998_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Match: HACD3 (3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol;Acc:HGNC:24175])

HSP 1 Score: 177.178 bits (448), Expect = 5.073e-50
Identity = 108/366 (29.51%), Postives = 189/366 (51.64%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            P V+W Q    + L +++ + +N  ++I E  L F  +G GA G   Y F  ++ L ++     +K+ +  + + ++K++   W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:    8 PHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------ESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Match: HACD3 (3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol;Acc:HGNC:24175])

HSP 1 Score: 164.851 bits (416), Expect = 8.712e-46
Identity = 103/345 (29.86%), Postives = 178/345 (51.59%), Query Frame = 1

Query:  148 KNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            +N  ++I E  L F  +G GA G   Y F  ++ L ++     +K+ +  + + ++K++   W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:    4 QNPAISITENVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------ESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 335

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Match: HACD3 (3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol;Acc:HGNC:24175])

HSP 1 Score: 164.851 bits (416), Expect = 3.555e-45
Identity = 103/348 (29.60%), Postives = 179/348 (51.44%), Query Frame = 1

Query:  139 INAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            +  +N  ++I E  L F  +G GA G   Y F  ++ L ++     +K+ +  + + ++K++   W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:   64 VGLQNPAISITENVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------ESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 398

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Match: HACD3 (3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol;Acc:HGNC:24175])

HSP 1 Score: 130.568 bits (327), Expect = 3.837e-34
Identity = 73/229 (31.88%), Postives = 126/229 (55.02%), Query Frame = 1

Query:  493 IESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            +ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:   16 LESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 243

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Match: HACD3 (3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbol;Acc:HGNC:24175])

HSP 1 Score: 130.568 bits (327), Expect = 3.837e-34
Identity = 73/229 (31.88%), Postives = 126/229 (55.02%), Query Frame = 1

Query:  493 IESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            +ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:   16 LESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 243

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Celegans
Match: hpo-8 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 [Source:UniProtKB/Swiss-Prot;Acc:O17040])

HSP 1 Score: 83.5741 bits (205), Expect = 3.396e-18
Identity = 67/218 (30.73%), Postives = 112/218 (51.38%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIA-FLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDF----VIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKD 1179
            YL+ YN+ Q  G+  +    +  L  +G+    ++Y  +  +L   Q  ++LE++HA +G V+S      MQV  R ++++ I+   S  +    +  L   WS  E++RY +Y L +LK+ I  FL +LRY+++  LYP+G   E   +  ++  + E K  ++ +PN  N+   F    +I  L YIP    GF  L   M GQRK+ +G   KK 
Sbjct:    6 YLVAYNVLQILGWSAILVKTVLGL-ANGLTWP-QLYESVEFELKIFQTAAILEVIHAIVGLVRSPVGTTAMQVTSRVVLVWPILHLCSTARFSIGVPLLLVAWSVTEVIRYSFYALSVLKQPIPYFLLYLRYTLFYVLYPMGVSGELLTLFASLNEVDEKKILTLEMPNRLNMGISFWWVLIIAALSYIP----GFPQLYFYMIGQRKKILGGGSKKK 217

[Close]

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIA-FLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDF----VIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKD 1179
            YL+ YN+ Q  G+  +    +  L  +G+    ++Y  +  +L   Q  ++LE++HA +G V+S      MQV  R ++++ I+   S  +    +  L   WS  E++RY +Y L +LK+ I  FL +LRY+++  LYP+G   E   +  ++  + E K  ++ +PN  N+   F    +I  L YIP    GF  L   M GQRK+ +G   KK 
Sbjct:    6 YLVAYNVLQILGWSAILVKTVLGL-ANGLTWP-QLYESVEFELKIFQTAAILEVIHAIVGLVRSPVGTTAMQVTSRVVLVWPILHLCSTARFSIGVPLLLVAWSVTEVIRYSFYALSVLKQPIPYFLLYLRYTLFYVLYPMGVSGELLTLFASLNEVDEKKILTLEMPNRLNMGISFWWVLIIAALSYIP----GFPQLYFYMIGQRKKILGGGSKKK 217

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Celegans
Match: R10E4.9 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [Source:UniProtKB/TrEMBL;Acc:Q21905])

HSP 1 Score: 54.6842 bits (130), Expect = 2.368e-8
Identity = 52/152 (34.21%), Postives = 74/152 (48.68%), Query Frame = 1

Query:  535 NLYLLMYNLFQYA----GYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEG 978
            N+ L +Y L  +     G+LY+F A      ++  E K   YP I   L+ +  +  L+I  ++    KS+P  VF+QV GR LVL+   V    +      F L A +   E+ R PYYL   L      LTWLRY+ +  LYP+GF  E 
Sbjct:    6 NMILFIYTLVLFILHGYGFLYIFHA------EYTSEFK---YPEIMWFLLFITSLQYLDIPFSFF-LTKSNPVAVFVQVSGRLLVLW---VASHMVSWKYAAFSLVAVYLLSELCRGPYYLSNCLGTPNRSLTWLRYNAFKVLYPVGFTCEA 144

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Fly
Match: Hacd2 (gene:FBgn0032524 transcript:FBtr0080519)

HSP 1 Score: 242.276 bits (617), Expect = 4.104e-75
Identity = 125/365 (34.25%), Postives = 210/365 (57.53%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATI-GFYYLMMRMYGQRKQKIG 1161
            M    P V+W Q+K  +LL + + +AK  + + +  +++FS  G GA G+  Y FE  +Y  +   ++++ + +N IE++++K   + WPRL + P K  WLK DF+ +   E D   +E  +  + + +     L + +        K+ TK   +Y++ YNL  + GYLY+      + Y+ G++   K Y  + +    +QL+  LE++H   G+ K SP + F QV GRN +LF ++     +   P +F++   WS VE+VRYPYYL  LL   +  LTWLRY+IW+PLYP+G + EG ++L+ +P ++E+K+F++ +PN +NI FD V+FL +Y+ L  I G Y +M  M   R +K+G
Sbjct:    1 MANLSPFVYWSQTKQTLLLKVDLKDAKGAIADFSPVSVNFSANGHGARGVNAYKFELHFYALIDDENATFVVSDNKIELQIRKLEPEWWPRLVATPQKPHWLKIDFDRWR-TEDDVEVEEKPRDVRQDYEKEYADLQKREL----GYIKEKTK--KVYMIFYNLAMFVGYLYIMVVMGVLYYRDGVDSIGKTYANVGNAFKFIQLLQYLEVMHPMFGYTKGSPVVPFFQVSGRNFILFLMIDMEPRMYAKPVVFYVFIIWSLVELVRYPYYLAQLLGREVGLLTWLRYTIWIPLYPMGILCEGIIVLRNIPYIEETKRFTVEMPNPWNITFDMVLFLKIYLMLLIIPGSYLVMSHMAKLRSKKLG 358

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Fly
Match: Hacd1 (gene:FBgn0032394 transcript:FBtr0080313)

HSP 1 Score: 92.4337 bits (228), Expect = 7.232e-21
Identity = 69/222 (31.08%), Postives = 112/222 (50.45%), Query Frame = 1

Query:  514 KDVTKPLNLYLLMYNLFQYAGYLYVFGACL--WILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFL----LLYIPLATIGFYYLMMRMYGQRKQKIG 1161
            K+ +    LYL  YN  Q  G+ Y+    +  +IL       +  ++ Y R  +I  Q  + +EIL+A  G VKS+P +   QVF R +V+  +V+     +  P +      W+  EI+RY YY L ++K    F+ +LRY+ ++ LYPIG   E      A    +E+  +S+ +PN +N  F +  FL    L YIP+    F  L + M+ QR++ +G
Sbjct:   16 KEPSAVTKLYLFAYNAGQVVGWSYILWQLVNYYILQGPEFRAQVTLWEYTRLAVIIFQNAAFVEILNASFGLVKSNPVVTGFQVFSRMMVVVGVVMATPTGKVSPGLPIALLAWAITEIIRYGYYALNIVKVVPHFVVFLRYTTFIVLYPIGVTGELLCFWWAQSYARENSVWSVVMPNKWNATFSYFGFLWIVMLGYIPI----FPQLYLHMFAQRRKILG 233

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
Match: hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;Acc:393441])

HSP 1 Score: 197.978 bits (502), Expect = 3.657e-58
Identity = 113/358 (31.56%), Postives = 187/358 (52.23%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQ 1143
            M+A  P V+W Q    I L ++I +A+++ + + E  L F G+G GA G   Y F  ++  PV P     K  +  + + ++K+ +  W RLT Q  K  +L  DF+ +  DESD   +   K  K NK      + +D F+  +K F          L MYNL Q+ GY ++F      L+  G +     +  I D +   Q+++++E+++  +G VK+     F+QV GRN +LF I     ++Q  P +F++   WS +EI RYP+Y+L  +      LTWLRY+IW+PLYP+G + E   +++++P+  E+K  SI LP A  +   F   L LY+ +  +G +     ++ Q
Sbjct:    1 MSALTPHVYWAQRHGEIYLRVEISDAQDLSIGVEENILQFRGQGHGAKGENEYEFSLEFLKPVKPEVKH-KSTQRQVNITVRKQEEVWWNRLTKQEKKPLFLAPDFDRWL-DESDAEMELREKEEKINKVSFESRVRKDPFLGLKKGF----------LFMYNLVQFLGYSWIFVNMTVRLFILGQDSFYDTFHTIADVMYFCQMLAIMEVINPAVGLVKTGVMPAFIQVMGRNFILFVIFGSLEDMQNKPVVFFVFYLWSTIEIFRYPFYMLACIDTEWKLLTWLRYTIWMPLYPLGVLAEAVAVIQSIPIFDETKLLSIPLPKATGLSLSFSYILQLYLVVMFLGLFINFRHLFKQ 346

[Close]

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQ 1143
            M+A  P V+W Q    I L ++I +A+++ + + E  L F G+G GA G   Y F  ++  PV P     K  +  + + ++K+ +  W RLT Q  K  +L  DF+ +  DESD   +   K  K NK      + +D F+  +K F          L MYNL Q+ GY ++F      L+  G +     +  I D +   Q+++++E+++  +G VK+     F+QV GRN +LF I     ++Q  P +F++   WS +EI RYP+Y+L  +      LTWLRY+IW+PLYP+G + E   +++++P+  E+K  SI LP A  +   F   L LY+ +  +G +     ++ Q
Sbjct:    1 MSALTPHVYWAQRHGEIYLRVEISDAQDLSIGVEENILQFRGQGHGAKGENEYEFSLEFLKPVKPEVKH-KSTQRQVNITVRKQEEVWWNRLTKQEKKPLFLAPDFDRWL-DESDAEMELREKEEKINKVSFESRVRKDPFLGLKKGF----------LFMYNLVQFLGYSWIFVNMTVRLFILGQDSFYDTFHTIADVMYFCQMLAIMEVINPAVGLVKTGVMPAFIQVMGRNFILFVIFGSLEDMQNKPVVFFVFYLWSTIEIFRYPFYMLACIDTEWKLLTWLRYTIWMPLYPLGVLAEAVAVIQSIPIFDETKLLSIPLPKATGLSLSFSYILQLYLVVMFLGLFINFRHLFKQ 346

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
Match: hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;Acc:393441])

HSP 1 Score: 185.652 bits (470), Expect = 1.753e-53
Identity = 112/364 (30.77%), Postives = 184/364 (50.55%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEE------NLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQ 1143
            M+A  P V+W Q    I L ++I +A+    +   +        SF G+G GA G   Y F  ++  PV P     K  +  + + ++K+ +  W RLT Q  K  +L  DF+ +  DESD   +   K  K NK      + +D F+  +K F          L MYNL Q+ GY ++F      L+  G +     +  I D +   Q+++++E+++  +G VK+     F+QV GRN +LF I     ++Q  P +F++   WS +EI RYP+Y+L  +      LTWLRY+IW+PLYP+G + E   +++++P+  E+K  SI LP A  +   F   L LY+ +  +G +     ++ Q
Sbjct:    1 MSALTPHVYWAQRHGEIYLRVEISDAQVKTTSFHSQLPDFSIICSFKGQGHGAKGENEYEFSLEFLKPVKPEVKH-KSTQRQVNITVRKQEEVWWNRLTKQEKKPLFLAPDFDRWL-DESDAEMELREKEEKINKVSFESRVRKDPFLGLKKGF----------LFMYNLVQFLGYSWIFVNMTVRLFILGQDSFYDTFHTIADVMYFCQMLAIMEVINPAVGLVKTGVMPAFIQVMGRNFILFVIFGSLEDMQNKPVVFFVFYLWSTIEIFRYPFYMLACIDTEWKLLTWLRYTIWMPLYPLGVLAEAVAVIQSIPIFDETKLLSIPLPKATGLSLSFSYILQLYLVVMFLGLFINFRHLFKQ 352

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
Match: hacd2 (3-hydroxyacyl-CoA dehydratase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6053])

HSP 1 Score: 101.679 bits (252), Expect = 5.951e-24
Identity = 75/232 (32.33%), Postives = 113/232 (48.71%), Query Frame = 1

Query:  496 ESEKLFKDVTKPLNL---YLLMYNLFQYAGYLYV-FGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIGPI 1167
             SE   K    P  L   YL++YN+   AG+L +  G     L +    G   +Y  I   L   Q  ++LEILH  +G V SS  +   QV  R  + + +      +Q++  +      W+  EI+RY +Y   LL      + W RY+ ++ LYP+G M E   I  A+P +Q++  +SI LPN +N  FD+  FL+     YIPL     Y+ MMR   QRK+ +G +
Sbjct:   13 HSESGHKKKKGPGTLATAYLVIYNVIMTAGWLVIAVGLVRAYLARGSYHG---LYYSIEKPLKFFQTGALLEILHCAVGIVPSSVVLTGFQVMSRVFLTWAVTHSVREVQSEDSVLLFVVAWTVTEIIRYSFYTFSLLNHLPYLIKWARYTFFIVLYPMGVMGELLTIYAALPYVQKAGLYSITLPNKYNFSFDYHTFLIFVMISYIPLFP-QLYFHMMR---QRKKVLGHV 237

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
Match: hacd2 (3-hydroxyacyl-CoA dehydratase 2 [Source:ZFIN;Acc:ZDB-GENE-030131-6053])

HSP 1 Score: 93.9745 bits (232), Expect = 1.719e-21
Identity = 66/208 (31.73%), Postives = 100/208 (48.08%), Query Frame = 1

Query:  496 ESEKLFKDVTKPLNL---YLLMYNLFQYAGYLYV-FGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIP 1095
             SE   K    P  L   YL++YN+   AG+L +  G     L +    G   +Y  I   L   Q  ++LEILH  +G V SS  +   QV  R  + + +      +Q++  +      W+  EI+RY +Y   LL      + W RY+ ++ LYP+G M E   I  A+P +Q++  +SI LPN +N  FD+  FL+     YIP
Sbjct:    9 HSESGHKKKKGPGTLATAYLVIYNVIMTAGWLVIAVGLVRAYLARGSYHG---LYYSIEKPLKFFQTGALLEILHCAVGIVPSSVVLTGFQVMSRVFLTWAVTHSVREVQSEDSVLLFVVAWTVTEIIRYSFYTFSLLNHLPYLIKWARYTFFIVLYPMGVMGELLTIYAALPYVQKAGLYSITLPNKYNFSFDYHTFLIFVMISYIP 213

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Match: lrp12 (LDL receptor related protein 12 [Source:Xenbase;Acc:XB-GENE-980112])

HSP 1 Score: 166.392 bits (420), Expect = 2.916e-46
Identity = 103/327 (31.50%), Postives = 166/327 (50.76%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFD 1065
            P VFW Q    + L +++ + +N  + I++  L+F  +G GA G+  Y F  +++ PV P       +   + + +KK  K  WPRL  Q  K  +L  D + +  DESD      +K   P        L     I    L+         YL MYNL Q+ G+ ++F      L+  G +     +  + D +   Q +++LEI++  +G VK+  A   +QV GRN +LF I+     +QT   +F++   WS +EI RYP+Y+L  L      LTW+RY+IW+PLYP+G + E   I++A+P+  E+ +FS+ LP  F + F 
Sbjct:   10 PHVFWAQRHHELYLRVELSDVQNPDITISDNVLNFKAQGHGAKGVNLYEFSLEFFAPVKPKFIQRSTQRQ-VAITVKKSEKLWWPRLIKQERKPRFLAPDCDRWL-DESD------LKTILP--------LHAIGRIRGSFLYLKRG-----YLFMYNLVQFLGFSWIFVNMTVRLFILGQDSFYDTFNSMGDMMYFCQTLALLEIINPLIGLVKTGVAPALIQVLGRNFILFFILGQLDEMQTKAIVFFIFYLWSSIEIFRYPFYMLACLDTEWKLLTWIRYTIWIPLYPLGALAEAASIIQAIPIFNETGRFSLRLPLEFTVSFS 315

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Match: lrp12 (LDL receptor related protein 12 [Source:Xenbase;Acc:XB-GENE-980112])

HSP 1 Score: 167.162 bits (422), Expect = 3.440e-46
Identity = 107/353 (30.31%), Postives = 176/353 (49.86%), Query Frame = 1

Query:   76 AFHPIVFWGQSKDYILLSIKIINAKNVV----------------------VNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESL-TEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFD 1065
            +  P VFW Q    + L +++ + + V+                      + I++  L+F  +G GA G+  Y F  +++ PV P  S+    +  + + +KK  K  WPRL  Q  K  +L  D + +  DESD   +   K  +   K  TES   ED F+  ++           YL MYNL Q+ G+ ++F      L+  G +     +  + D +   Q +++LEI++  +G VK+  A   +QV GRN +LF I+     +QT   +F++   WS +EI RYP+Y+L  L      LTW+RY+IW+PLYP+G + E   I++A+P+  E+ +FS+ LP  F + F 
Sbjct:    7 SLTPHVFWAQRHHELYLRVELSDVQVVLGMGGVASLPLNYISQHTDTNPDITISDNVLNFKAQGHGAKGVNLYEFSLEFFAPVKPKRST----QRQVAITVKKSEKLWWPRLIKQERKPRFLAPDCDRWL-DESDAEMELREKEEERITKIRTESRKREDPFLYLKRG----------YLFMYNLVQFLGFSWIFVNMTVRLFILGQDSFYDTFNSMGDMMYFCQTLALLEIINPLIGLVKTGVAPALIQVLGRNFILFFILGQLDEMQTKAIVFFIFYLWSSIEIFRYPFYMLACLDTEWKLLTWIRYTIWIPLYPLGALAEAASIIQAIPIFNETGRFSLRLPLEFTVSFS 344

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Match: lrp12 (LDL receptor related protein 12 [Source:Xenbase;Acc:XB-GENE-980112])

HSP 1 Score: 156.377 bits (394), Expect = 7.773e-43
Identity = 97/302 (32.12%), Postives = 156/302 (51.66%), Query Frame = 1

Query:   76 AFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESL-TEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEG 978
            +  P VFW Q    + L +++ + +N  + I++  L+F  +G GA G+  Y F  +++ PV P       +   + + +KK  K  WPRL  Q  K  +L  D + +  DESD   +   K  +   K  TES   ED F+  ++           YL MYNL Q+ G+ ++F      L+  G +     +  + D +   Q +++LEI++  +G VK+  A   +QV GRN +LF I+     +QT   +F++   WS +EI RYP+Y+L  L      LTW+RY+IW+PLYP+G + EG
Sbjct:    7 SLTPHVFWAQRHHELYLRVELSDVQNPDITISDNVLNFKAQGHGAKGVNLYEFSLEFFAPVKPKFIQRSTQRQ-VAITVKKSEKLWWPRLIKQERKPRFLAPDCDRWL-DESDAEMELREKEEERITKIRTESRKREDPFLYLKRG----------YLFMYNLVQFLGFSWIFVNMTVRLFILGQDSFYDTFNSMGDMMYFCQTLALLEIINPLIGLVKTGVAPALIQVLGRNFILFFILGQLDEMQTKAIVFFIFYLWSSIEIFRYPFYMLACLDTEWKLLTWIRYTIWIPLYPLGALAEG 296

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Match: HACD1 (3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;Acc:100145048])

HSP 1 Score: 98.5969 bits (244), Expect = 9.721e-23
Identity = 72/245 (29.39%), Postives = 120/245 (48.98%), Query Frame = 1

Query:  463 LTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIGP--IVKKD 1179
            +  S  E    E E   K +      +L  YN+   AG+L +  A +    + G      +Y  I+  L   Q  ++LE++H  +G V +S  +  +QV  R  +++ I      +Q++  +      W+  EI RY YY   LL     F+ W RY++++ LYP+G + E   I  A+P +++S  +S+ LPN +N+ FD+  FL++    YIPL    F  L   M  QR++ +    IV+KD
Sbjct:    1 MASSDDEGSVEEKEHTKKKIGPLATAWLTFYNIAMTAGWLVLAIAMIRFYAEKGTH--KGLYRNIQKTLKFFQTFALLELVHCALGIVHTSVLVTGVQVSSRIFMVWFITSSIKQVQSEHGVLIFLVVWTVTEITRYSYYTFKLLNHLPYFIKWARYNLFIVLYPVGVVGELLTIYAALPHVRKSAMYSLRLPNKYNVSFDYYYFLIIAMCSYIPL----FPQLYFHMLRQRRRVLHGEVIVEKD 239

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Match: kif2a (kinesin heavy chain member 2A [Source:Xenbase;Acc:XB-GENE-951755])

HSP 1 Score: 94.7449 bits (234), Expect = 2.647e-21
Identity = 65/217 (29.95%), Postives = 104/217 (47.93%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIGPIVKKD 1179
            YL++YN+   AG+L +    +      G      +Y  I   L   Q  ++LEI H  +G V SS  +   QV  R  + + +      +Q +  +      W+  EI+RY +Y   LL      + W RY++++ LYP+G   E   I  A+P ++++  +SI LPN +N  FD+  FL+L    YIP+    F  L   M+ QR++ I    KK 
Sbjct:   36 YLVIYNVVMTAGWLVIAVGLVRTYLTKG--SYHNLYYSIERPLKFFQTGALLEIGHCAVGIVPSSVVLTAFQVMSRVFLTWAVTHSVREVQNEDSVLLFVVAWTITEIIRYSFYTFSLLNHLPYIIKWARYTLFIVLYPMGVTGELLTIYAALPTVKKTGLYSISLPNKYNFSFDYYTFLILVMMSYIPI----FPQLYFHMFHQRRKVITAEHKKS 246

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
Match: Hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:MGI Symbol;Acc:MGI:1889341])

HSP 1 Score: 175.252 bits (443), Expect = 1.684e-49
Identity = 105/366 (28.69%), Postives = 190/366 (51.91%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            P V+W Q    + L +++ + +N  ++I +  L F  +G GA G   Y F  ++ L ++    ++++ +  + + ++K+    W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          E E   + +T     YL MYNL Q  G+ ++F       +  G E     +  + D +   Q+++++E L+A +G V S+P +   +Q  GRN +LF +      +Q    +F++  +WS +EI RYP+Y+L  +  +   LTWLRY++W+PLYP+G ++E   +++++P+  ES +FS  LP    ++  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:    8 PHVYWAQRHRELYLRVELSDVQNPAISITDNVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPAYRLTQRQVNITVQKKGSHWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------EREGSPETLTNLKKGYLFMYNLVQLLGFSWIFVNLTVRFFILGKESFYDTFHNVADMMYFCQMLALVETLNAAIG-VTSTPVLPALIQFLGRNFILFLVFGTMEEMQNKAVVFFVFYSWSAIEIFRYPFYMLSCIDMDWKVLTWLRYTMWIPLYPLGCLSEAVAVIQSIPVFNESGRFSFTLPYPVKMKVRFSFFLQVYLVMLFLGLYINFRHLYKQRRRRYGQKKKK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
Match: Hacd1 (3-hydroxyacyl-CoA dehydratase 1 [Source:MGI Symbol;Acc:MGI:1353592])

HSP 1 Score: 96.2857 bits (238), Expect = 4.591e-22
Identity = 67/219 (30.59%), Postives = 111/219 (50.68%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIGP--IVKKD 1179
            +L  YN+   AG+L +  A +    + G      +Y  I+  L   Q  ++LE++H  +G V +S  +  +QV  R  +++ I      +Q +  +     +W+  EI RY +Y   LL     F+ W RY++++ LYP+G   E   I  A+P +++S  FS+ LPN +N+ FD+  FLL+    YIPL    F  L   M  QR++ +    I +KD
Sbjct:   35 WLTFYNIAMTAGWLVLAIAMVRFYMEKGTH--RGLYKSIQKTLKFFQTFALLEVVHCLIGIVPTSVLVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVTEITRYSFYTFSLLDHLPHFIKWARYNLFIILYPVGVAGELLTIYAALPYVKKSGMFSVRLPNKYNVSFDYYYFLLITMASYIPL----FPQLYFHMLRQRRKVLHGEVIAEKD 247

[Close]

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIGP--IVKKD 1179
            +L  YN+   AG+L +  A +    + G      +Y  I+  L   Q  ++LE++H  +G V +S  +  +QV  R  +++ I      +Q +  +     +W+  EI RY +Y   LL     F+ W RY++++ LYP+G   E   I  A+P +++S  FS+ LPN +N+ FD+  FLL+    YIPL    F  L   M  QR++ +    I +KD
Sbjct:   35 WLTFYNIAMTAGWLVLAIAMVRFYMEKGTH--RGLYKSIQKTLKFFQTFALLEVVHCLIGIVPTSVLVTGVQVSSRIFMVWLITHSIKPIQNEESVVLFLVSWTVTEITRYSFYTFSLLDHLPHFIKWARYNLFIILYPVGVAGELLTIYAALPYVKKSGMFSVRLPNKYNVSFDYYYFLLITMASYIPL----FPQLYFHMLRQRRKVLHGEVIAEKD 247

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
Match: Hacd2 (3-hydroxyacyl-CoA dehydratase 2 [Source:MGI Symbol;Acc:MGI:1918007])

HSP 1 Score: 95.5153 bits (236), Expect = 9.690e-22
Identity = 64/208 (30.77%), Postives = 103/208 (49.52%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQ 1152
            YL++YN+   AG+L +    +      G      +Y  I   L   Q  ++LEILH  +G V SS  +   QV  R  +++ +      +Q++  +      W+  EI+RY +Y   LL      + W RY++++ LYP+G   E   I  A+P ++++  +SI LPN +N  FD+  FL+L    YIPL    F  L   M  QR++
Sbjct:   41 YLVIYNVVMTAGWLVIAVGLVRAYLAKG--SYHSLYYSIERPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYIIKWARYTLFIVLYPMGVTGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYHAFLILIMISYIPL----FPQLYFHMIHQRRK 242

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
Match: Hacd4 (3-hydroxyacyl-CoA dehydratase 4 [Source:MGI Symbol;Acc:MGI:1914025])

HSP 1 Score: 91.2781 bits (225), Expect = 2.926e-20
Identity = 56/205 (27.32%), Postives = 105/205 (51.22%), Query Frame = 1

Query:  535 NLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRK 1149
            N+YL +Y L Q+ G+ ++        +  G +  +  +  I   +   Q +S+LE+LH Y+G   +     F+Q+  R ++LF ++     +Q    +  L   W+ +++VRY Y +L ++  + A LTWL  ++W+P+YP+  + E   I +++P  +     S  LP   +  F +V  L LY+ +  IG Y+    +Y +RK
Sbjct:   37 NVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYV--LKLYLMMLFIGMYFTYSHLYTERK 239

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Match: sp|Q7SY06|HACD3_DANRE (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio OX=7955 GN=hacd3 PE=2 SV=2)

HSP 1 Score: 197.978 bits (502), Expect = 2.761e-57
Identity = 113/358 (31.56%), Postives = 187/358 (52.23%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQ 1143
            M+A  P V+W Q    I L ++I +A+++ + + E  L F G+G GA G   Y F  ++  PV P     K  +  + + ++K+ +  W RLT Q  K  +L  DF+ +  DESD   +   K  K NK      + +D F+  +K F          L MYNL Q+ GY ++F      L+  G +     +  I D +   Q+++++E+++  +G VK+     F+QV GRN +LF I     ++Q  P +F++   WS +EI RYP+Y+L  +      LTWLRY+IW+PLYP+G + E   +++++P+  E+K  SI LP A  +   F   L LY+ +  +G +     ++ Q
Sbjct:    1 MSALTPHVYWAQRHGEIYLRVEISDAQDLSIGVEENILQFRGQGHGAKGENEYEFSLEFLKPVKPEVKH-KSTQRQVNITVRKQEEVWWNRLTKQEKKPLFLAPDFDRWL-DESDAEMELREKEEKINKVSFESRVRKDPFLGLKKGF----------LFMYNLVQFLGYSWIFVNMTVRLFILGQDSFYDTFHTIADVMYFCQMLAIMEVINPAVGLVKTGVMPAFIQVMGRNFILFVIFGSLEDMQNKPVVFFVFYLWSTIEIFRYPFYMLACIDTEWKLLTWLRYTIWMPLYPLGVLAEAVAVIQSIPIFDETKLLSIPLPKATGLSLSFSYILQLYLVVMFLGLFINFRHLFKQ 346

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Match: sp|Q5ZM57|HACD3_CHICK (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Gallus gallus OX=9031 GN=HACD3 PE=2 SV=1)

HSP 1 Score: 187.578 bits (475), Expect = 2.458e-53
Identity = 115/368 (31.25%), Postives = 192/368 (52.17%), Query Frame = 1

Query:   73 TAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
             +  P V W Q    + L +++ + KN  V+IA+  L F  +G GA G   Y F+ ++  PV P     ++ +  + + ++K+    W RLT Q  +  +L  DF+ +  DESD   +   K  +   K   ES    D       FK + K    YL+MYNL Q+ G+ ++F      L+  G +     +  I D +   Q ++++EIL++ +G V+S      +QVFGRN +LF ++     +Q+   +F+L   WS +E+ RYPYY+L  +      LTWLRY+ W+PLYP+G + E   +++++P+  E+ +FS+ LPN  N+   F   L +Y+    +G +     +Y QRKQ +GP  +K
Sbjct:    4 CSLRPHVHWAQRHRELYLRVELSDVKNPDVSIADNVLRFRAQGHGAKGDNIYEFQIEFLEPVEPKPVC-RVTQRQLNITVQKKESSWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELKEKEEEKINKMKIESRVPKD------PFKHLKKG---YLIMYNLVQFLGFSWIFVNMTVRLFILGKDSFYDTFHTIADMMYFCQTLALMEILNSLIGLVRSPLIPAVIQVFGRNFILFVVLGSLEEMQSKAVVFFLFYFWSIIELFRYPYYMLSCMGIEWKPLTWLRYTSWIPLYPLGGLAEAVCLIQSIPIFSETGKFSLGLPNPLNVTIQFSFLLQMYLIALFLGLFVNFRYLYKQRKQHLGPKKRK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Match: sp|A7YY55|HACD3_BOVIN (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Bos taurus OX=9913 GN=HACD3 PE=2 SV=1)

HSP 1 Score: 179.489 bits (454), Expect = 2.724e-50
Identity = 107/364 (29.40%), Postives = 183/364 (50.27%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            P V+W Q    + L +++ + +N  ++I E  L F  +G GA G   Y F  ++ L ++     +K+ +  + + ++K+    W RLT Q  +  +L  DF+ +  DESD   +   K  +   K   ES    + + S K           YL MYNL Q+ G+ ++F       +  G E     +  + D +   Q+++ +E ++A +G  KS       Q+ GRN +LF I      +Q    +F++   WS VEI RYP+Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ L  +G Y     +Y QR+++ G   KK
Sbjct:    8 PHVYWAQRHHELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPVYKLTQRQVNITVQKKESQWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEEQLNKLRLESQGSPETLTSLK---------KGYLFMYNLVQFLGFSWIFVNMTVRFFILGKESFYDTFHTVADMMYFCQMLAAVESINAAIGVTKSPVVPSLFQLLGRNFILFIIFGTMEEMQNKAVVFFVFYIWSTVEIFRYPFYMLSCIDMDWKVLTWLRYTVWIPLYPMGCLAEAVSVIQSIPVFNETGRFSFTLPYPVKIKVRFSFFLQIYLILLFLGLYVNFRYLYKQRRRRFGQKKKK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Match: sp|Q9P035|HACD3_HUMAN (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Homo sapiens OX=9606 GN=HACD3 PE=1 SV=2)

HSP 1 Score: 177.178 bits (448), Expect = 2.436e-49
Identity = 108/366 (29.51%), Postives = 189/366 (51.64%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            P V+W Q    + L +++ + +N  ++I E  L F  +G GA G   Y F  ++ L ++     +K+ +  + + ++K++   W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          ESE   + +T     YL MYNL Q+ G+ ++F          G E     +  + D +   Q+++V+E ++A +G V +SP +   +Q+ GRN +LF I      +Q    +F++   WS +EI RY +Y+L  +  +   LTWLRY++W+PLYP+G + E   +++++P+  E+ +FS  LP    I+  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:    8 PHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------ESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIG-VTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Match: sp|Q8K2C9|HACD3_MOUSE (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 OS=Mus musculus OX=10090 GN=Hacd3 PE=1 SV=2)

HSP 1 Score: 175.252 bits (443), Expect = 1.178e-48
Identity = 105/366 (28.69%), Postives = 190/366 (51.91%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHN-KPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKK 1176
            P V+W Q    + L +++ + +N  ++I +  L F  +G GA G   Y F  ++ L ++    ++++ +  + + ++K+    W RLT Q  +  +L  DF+ +  DESD   +   K   + NK  L          E E   + +T     YL MYNL Q  G+ ++F       +  G E     +  + D +   Q+++++E L+A +G V S+P +   +Q  GRN +LF +      +Q    +F++  +WS +EI RYP+Y+L  +  +   LTWLRY++W+PLYP+G ++E   +++++P+  ES +FS  LP    ++  F  FL +Y+ +  +G Y     +Y QR+++ G   KK
Sbjct:    8 PHVYWAQRHRELYLRVELSDVQNPAISITDNVLHFKAQGHGAKGDNVYEFHLEF-LDLVKPEPAYRLTQRQVNITVQKKGSHWWERLTKQEKRPLFLAPDFDRWL-DESDAEMELRAKEEERLNKLRL----------EREGSPETLTNLKKGYLFMYNLVQLLGFSWIFVNLTVRFFILGKESFYDTFHNVADMMYFCQMLALVETLNAAIG-VTSTPVLPALIQFLGRNFILFLVFGTMEEMQNKAVVFFVFYSWSAIEIFRYPFYMLSCIDMDWKVLTWLRYTMWIPLYPLGCLSEAVAVIQSIPVFNESGRFSFTLPYPVKMKVRFSFFLQVYLVMLFLGLYINFRHLYKQRRRRYGQKKKK 360

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Match: G4VGD4 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Schistosoma mansoni OX=6183 GN=Smp_121880 PE=3 SV=1)

HSP 1 Score: 318.161 bits (814), Expect = 4.495e-100
Identity = 157/387 (40.57%), Postives = 242/387 (62.53%), Query Frame = 1

Query:   76 AFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDE------SVKHNKPNKKDL--TESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYL 1209
              HPIV+WGQS++Y+ LSIK+ NA    + I +E   FS  G GA G+K Y F   YYLP++P  S + +    + VKL+KELKD W RLT    +LPW++ DF+ + F++SD  ++E      +V H    ++D    E +   D  E E     +  PL +YL ++N+ Q++GYLYV GA ++ L ++    K   Y +  D+L+ VQ++S+LE LHA++GW++    + V  Q+FGR+ VLFCIV+PH+   +    +WL  +WS +E+VRYPYY+L LL      +T+LR+++W+ LYPIGF+ EGKLI++++PLL ES++F + LPN+ N+ FDF  FL +Y+   + G YY M  +Y +R++ IGP   K      +L ++
Sbjct:    7 CIHPIVYWGQSEEYVFLSIKVANANVDSITINQEEFMFSAMGTGADGVKKYEFSISYYLPIIPEESRYVVTSLSVNVKLRKELKDSWSRLTLGNQRLPWVRSDFDRYQFNDSDLENNEEECLNVNVVHPSKEERDKHNEEQMMLIDAEEWEAFLNLIKNPLTIYLFIFNVVQFSGYLYVCGALVYGLMQYKEVHKIPFYEWTIDRLVFVQILSILEPLHAFLGWIRGGSILPVVFQLFGRSFVLFCIVLPHAEFHSASTTYWLFFSWSLIEVVRYPYYILSLLSFQNGLITYLRHTLWIILYPIGFICEGKLIIRSLPLLIESRKFCLELPNSANVSFDFTTFLQIYMFSMSFGLYYNMRHLYLRRRKIIGPRPIKGADQMGYLSFI 393

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Match: A0A183R4F5 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Schistosoma rodhaini OX=6188 PE=3 SV=1)

HSP 1 Score: 313.923 bits (803), Expect = 1.760e-98
Identity = 160/389 (41.13%), Postives = 242/389 (62.21%), Query Frame = 1

Query:   76 AFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLT--SQPMKLPWLKCDFNNFFFDESDYGSDE------SVKHNKPNKKDL--TESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAM-VFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYL 1209
              HPIV+WGQS++YI LSIK+ NA    + I +E   FS  G GA G+K Y F   YYLP++P  S + +    + VKL+KELKD W RLT      +LPW++ DF+ + F++SD  ++E      +V H    ++D    E +   D  E E     +  PL +YL ++N+ Q++GYLYV GA ++ L ++    K   Y +  D+L+ VQ++S+LE LHA++GW++S   + V  Q+FGR+ VLFCIV+PH+   +    +WL  +WS +E+VRYPYY+L LL      +T+LR+++W+ LYPIGF+ EGKLI++++PLL ES++F + LPN  NI FDF  FL +Y+   + G YY M  +Y +R++ IGP   K      +L ++
Sbjct:    7 CIHPIVYWGQSEEYIFLSIKVANANVDSITINQEEFMFSAMGTGADGVKKYEFSISYYLPIIPEESRYVVTSLSVNVKLRKELKDSWSRLTLXXXXQRLPWVRPDFDRYQFNDSDLENNEEECLNVNVVHPSKEERDKHNEEQMMLIDAEEWEAFLNLIKNPLTIYLFIFNVVQFSGYLYVCGALVYGLMQYKEVHKIPFYEWTIDRLVFVQILSILEPLHAFLGWIRSGSILPVVFQLFGRSFVLFCIVLPHAEFHSASTTYWLFFSWSLIEVVRYPYYILSLLSFQNGLITYLRHTLWIILYPIGFICEGKLIIRSLPLLIESRKFCLELPNPANISFDFTTFLQIYMFSMSFGLYYNMRHLYLRRRKIIGPRPIKGSDQMGYLSFI 395

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Match: A0A4S2MFA3 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Opisthorchis felineus OX=147828 GN=CRM22_001351 PE=3 SV=1)

HSP 1 Score: 311.612 bits (797), Expect = 2.028e-97
Identity = 166/394 (42.13%), Postives = 236/394 (59.90%), Query Frame = 1

Query:   82 HPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDY---GSDES----VKHNKPNKKDLTESLTEDDFIESEK----LFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEG-------KSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYL 1209
            HP V WGQ++ Y+ LS+++ +A++V V+I +E+L+F+  G GA G + Y F   YYLP++   S + +    I ++L+KELKD WPRLT Q  KLPW   DF+ + FD SD    G D      VK  +P K++      E   IE E+      K +  PL +YLL++NLFQ+AG+L VFG+ + +L K  +EG       +S I      +L  VQL++ LE LH  + WV+       +QV GR LVLF IV+PH  L TD  +FWL   WS +E+ RYP+Y+  LL      LT+LRY+ W+PLYPIGFM EGKLI++A+P L +S++FS  +PNA N+ FDF +FL  Y+      FY+LM  MY QR++ +GP  +       F  Y+
Sbjct:   16 HPFVKWGQNETYVFLSVQLGDAEDVAVDITDESLTFAAVGNGAHGREQYRFRLDYYLPIVAKQSRYTVTGRAILIRLRKELKDAWPRLTVQSEKLPWTHLDFDLYQFDASDAEPSGDDAEGGVKVKVIRPTKEERELHNAEMRAIEMEEEWEAFLKVLKHPLTIYLLLFNLFQFAGFLSVFGSLVLVLLK--VEGYVPRDWFESSI-----SRLAVVQLLAFLEPLHVCLRWVRGGILASLLQVSGRALVLFLIVIPHKELHTDSSVFWLFFVWSAIEVQRYPFYICSLLGYKNGLLTYLRYTSWIPLYPIGFMCEGKLIVRALPWLTKSRRFSYSMPNALNMAFDFPMFLHTYLVGMIAVFYFLMRYMYAQRRRVLGPRPRVGADQMGFFSYI 402

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Match: A0A4S2MAZ7 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Opisthorchis felineus OX=147828 GN=CRM22_001351 PE=3 SV=1)

HSP 1 Score: 311.227 bits (796), Expect = 2.364e-97
Identity = 166/394 (42.13%), Postives = 236/394 (59.90%), Query Frame = 1

Query:   82 HPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDY---GSDES----VKHNKPNKKDLTESLTEDDFIESEK----LFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEG-------KSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYL 1209
            HP V WGQ++ Y+ LS+++ +A++V V+I +E+L+F+  G GA G + Y F   YYLP++   S + +    I ++L+KELKD WPRLT Q  KLPW   DF+ + FD SD    G D      VK  +P K++      E   IE E+      K +  PL +YLL++NLFQ+AG+L VFG+ + +L K  +EG       +S I      +L  VQL++ LE LH  + WV+       +QV GR LVLF IV+PH  L TD  +FWL   WS +E+ RYP+Y+  LL      LT+LRY+ W+PLYPIGFM EGKLI++A+P L +S++FS  +PNA N+ FDF +FL  Y+      FY+LM  MY QR++ +GP  +       F  Y+
Sbjct:    9 HPFVKWGQNETYVFLSVQLGDAEDVAVDITDESLTFAAVGNGAHGREQYRFRLDYYLPIVAKQSRYTVTGRAILIRLRKELKDAWPRLTVQSEKLPWTHLDFDLYQFDASDAEPSGDDAEGGVKVKVIRPTKEERELHNAEMRAIEMEEEWEAFLKVLKHPLTIYLLLFNLFQFAGFLSVFGSLVLVLLK--VEGYVPRDWFESSI-----SRLAVVQLLAFLEPLHVCLRWVRGGILASLLQVSGRALVLFLIVIPHKELHTDSSVFWLFFVWSAIEVQRYPFYICSLLGYKNGLLTYLRYTSWIPLYPIGFMCEGKLIVRALPWLTKSRRFSYSMPNALNMAFDFPMFLHTYLVGMIAVFYFLMRYMYAQRRRVLGPRPRVGADQMGFFSYI 395

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Match: A0A419Q398 (Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase (Fragment) OS=Clonorchis sinensis OX=79923 GN=Hacd3 PE=3 SV=1)

HSP 1 Score: 313.153 bits (801), Expect = 1.590e-96
Identity = 169/394 (42.89%), Postives = 239/394 (60.66%), Query Frame = 1

Query:   82 HPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDY--GSDES-----VKHNKPNKKDLTESLTEDDFIESEK----LFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEG-------KSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYL 1209
            HP V WGQ++ ++ LS+++ +A++V V+I +E L+F+  G GA G + Y F   YYLP++   S + +    I ++L+KELKD WPRLT Q  KLPW   DF+ + FD SD     DE+     VK  +P K++      E   IE E+      K +  PL +YLL++NLFQ+AG+L VFG+ + +L K  +EG       +S I      +L  VQL++ LE LH  + WV+       +QV GR LVLF IVVPH  L TD  +FWL   WS +E+ RYP+Y+  LL      LT+LRY+ W+PLYPIGFM EGKLI++A+P L +S++FS  +PNA N+ FDF +FL  Y+   T GFY+LM  MYGQR++ +GP  +       F  Y+
Sbjct:    9 HPFVKWGQNETHVFLSVQLGDAEDVAVDITDEWLTFAAVGNGALGREQYRFRLDYYLPIVAKQSRYTVTGRAILIRLRKELKDAWPRLTIQSEKLPWAHLDFDLYQFDASDEEPSGDEAEGDVKVKVIRPTKEERELHNAEMRAIEMEEEWEAFLKVLKHPLTIYLLLFNLFQFAGFLSVFGSLVLVLLK--VEGYVPRDWFESSI-----SRLAVVQLLAFLEPLHVCLRWVRGGLLASLLQVSGRALVLFLIVVPHKELHTDSSVFWLFFVWSAIEVQRYPFYICSLLGYKNGLLTYLRYTSWIPLYPIGFMCEGKLIVRALPWLIKSRRFSYSMPNALNMAFDFPLFLHAYLVGMTAGFYFLMRYMYGQRRRVLGPRPRVGADQMGFFSYI 395

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Match: hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;Acc:103030450])

HSP 1 Score: 191.43 bits (485), Expect = 1.020e-55
Identity = 113/350 (32.29%), Postives = 182/350 (52.00%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYY 1119
            M    P VFW Q    I L ++I +AKN+ +++ E  L F G+G GA G   Y F  ++  PV P     K  +  + + ++K+    W RLT Q  K  +L  DF+ +  DESD   +   K  K NK  +   + +D F+  +K           YL MYNL Q+ G+ ++F      L+  G +     +  I D +   Q+++++E+++  +G VKS     F+QV GRN++LF I      +Q  P +F++   WS +EI RYP+Y+L  +      LTWLRY+IW+PLYP+G + E   +++++P+  E+K  SI LP A      F   L  Y+ +  +G ++
Sbjct:    1 MQTLTPHVFWAQRHGDIYLRVEISDAKNLDISVQENVLRFRGQGHGAKGENEYEFSLEFLKPVKPEVKH-KSTQRQVNIAVRKQGHCWWDRLTKQEKKPVFLAPDFDRWL-DESDAEMELKEKEEKINKVSVESRIRKDPFLGLKKG----------YLFMYNLVQFLGFSWIFVNMTVRLFILGQDSFYDTFHTIADVMYFCQMLAIIEVINPALGLVKSGVIPAFIQVMGRNVILFVIFGSLEEMQNKPVVFFVFYLWSAIEIFRYPFYMLACIDTEWKMLTWLRYTIWMPLYPLGVLAEAVSVIQSIPIFDETKFLSIPLPAALGSSISFSYILRFYLLIMFLGLFF 338

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Match: hacd2 (3-hydroxyacyl-CoA dehydratase 2 [Source:NCBI gene;Acc:103030449])

HSP 1 Score: 99.3673 bits (246), Expect = 3.351e-23
Identity = 68/212 (32.08%), Postives = 105/212 (49.53%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYV-FGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIG 1161
            YL++YN+   AG+L +  G     L +    G   +Y  I   L   Q  ++LEILH  +G V SS  +   QV  R  + + +      +Q++  +      W+  EI+RY +Y   LL      + W RY+ ++ LYP+G   E   I  A+P +Q++  +S+ LPN +N  FD+  FL+L    YIPL    F  L   M  QRK+ +G
Sbjct:   31 YLVIYNVVMTAGWLVIAVGLVRAYLTRGSYHG---LYYSIEKPLKFFQTGALLEILHCAVGIVPSSVVLTGFQVLSRVFLTWAVTHSVREVQSEDSVLLFVVAWTITEIIRYSFYTFSLLNHLPYLIKWARYTFFIVLYPMGVTGELLTIYAALPYVQKTGLYSVTLPNKYNFSFDYYTFLILTMVSYIPL----FPQLYFHMLRQRKKVLG 235

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Match: hacd1 (3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;Acc:103025300])

HSP 1 Score: 93.5893 bits (231), Expect = 2.932e-21
Identity = 65/219 (29.68%), Postives = 110/219 (50.23%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDF----VIFLLLYIPLATIGFYYLMMRMYGQRKQKIGP--IVKKD 1179
            +L +YN+   AG+L +  A +    + G      +Y  I   L   Q  ++LE+ H  +G V++S  +  +QV  R  +++ I      +Q    +      W+  EI RY +Y   LL     F+ W RY++++ +YP+G + E   I  A+P ++ S  +S+ LPN +N+ FD+    +I +L YIPL    F  L   M  QR++ +    IV+KD
Sbjct:   30 WLTVYNIAMTAGWLVLAVAMIRFYLQKGTH--RGLYRSIARTLKFFQTFALLEVGHCAIGIVRTSVIVTGVQVCSRIFMVWFIASSIRQVQNQESVILFLVVWTVTEITRYSFYTFNLLNHLPYFIKWARYNMFIVMYPLGVIGELMTIYAALPYVRRSGMYSLRLPNTYNVSFDYYYFLIIVMLSYIPL----FPQLYFHMLRQRRRVLHGEVIVEKD 242

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Match: ENSAMXT00000037901.1 (pep primary_assembly:Astyanax_mexicanus-2.0:5:1308226:1316371:-1 gene:ENSAMXG00000030657.1 transcript:ENSAMXT00000037901.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 91.6633 bits (226), Expect = 2.017e-20
Identity = 53/179 (29.61%), Postives = 96/179 (53.63%), Query Frame = 1

Query:  538 LYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNA--FNIQFDF 1068
            ++L +Y++ Q+ G+ + F      L   G +     +      L + Q+++VLE+++A +G V +      +Q+ GRN VLF ++     +Q     F +   WS +E+ R+P  +L ++      LTWL  + WV LYP+  + EG  +L+A+PL  E++ +S+ LP +  F+I F F
Sbjct:   54 VFLFLYHVIQFLGFTWTFSLLTANLILLGHDVLYSAFSSCAAVLYSCQVLAVLEVMNAALGLVNTPVLPALIQMSGRNTVLFVVLGSLPEMQERTVTFCVLYLWSSMEMFRHPVEMLAVVGAEWRVLTWLWNATWVLLYPLSTVAEGAAVLQALPLFDETRLYSVALPESVGFSISFSF 232

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Match: hacd1 (3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;Acc:103025300])

HSP 1 Score: 88.9669 bits (219), Expect = 1.540e-19
Identity = 55/189 (29.10%), Postives = 96/189 (50.79%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDF----VIFLLLYIP 1095
            +L +YN+   AG+L +  A +    + G      +Y  I   L   Q  ++LE+ H  +G V++S  +  +QV  R  +++ I      +Q    +      W+  EI RY +Y   LL     F+ W RY++++ +YP+G + E   I  A+P ++ S  +S+ LPN +N+ FD+    +I +L YIP
Sbjct:   30 WLTVYNIAMTAGWLVLAVAMIRFYLQKGTH--RGLYRSIARTLKFFQTFALLEVGHCAIGIVRTSVIVTGVQVCSRIFMVWFIASSIRQVQNQESVILFLVVWTVTEITRYSFYTFNLLNHLPYFIKWARYNMFIVMYPLGVIGELMTIYAALPYVRRSGMYSLRLPNTYNVSFDYYYFLIIVMLSYIP 216

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Sea Lamprey
Match: si:ch73-41h24.1 (3-hydroxyacyl-CoA dehydratase 4 [Source:HGNC Symbol;Acc:HGNC:20920])

HSP 1 Score: 96.6709 bits (239), Expect = 4.829e-23
Identity = 69/228 (30.26%), Postives = 115/228 (50.44%), Query Frame = 1

Query:  508 LFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQ--FDFVI--FLLLYIPLA-TIGFYYLMMRMYGQRKQKIGPIVKK 1176
            L  D       YL +Y+L Q+ G+ +VF      +   G +     +  I + +   Q +S+LE++++ +G  KS+     +QV  RNL+LF ++     LQ    +F +   WS +EI RYPYY+L  L      LTWLRYS W+PL P+    E   +L+++   + S +  +      NI   F +V+  +LLL +PL   +  +YL    Y QR++ +  + +K
Sbjct:    6 LVADFEPARKYYLFIYSLMQFLGHSWVFVNMTVRMLHFGEDSMIDTFYAIGEVMSYCQALSLLEVINSLLGLSKSALIPTILQVLSRNLLLFVVIWNQEELQNTVVVFAVFYLWSSIEIFRYPYYMLASLSMEWELLTWLRYSFWLPLCPLVLFAEVICVLQSLEHFEHSGEVFLNFQEPLNISALFPYVLYTYLLLILPLRFIVNSHYL----YKQRQKNLEMLKQK 229

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Sea Lamprey
Match: hacd1 (3-hydroxyacyl-CoA dehydratase 1 [Source:ZFIN;Acc:ZDB-GENE-170413-2])

HSP 1 Score: 94.3597 bits (233), Expect = 4.943e-22
Identity = 66/213 (30.99%), Postives = 108/213 (50.70%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSK--IYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIG 1161
            +L++YN    AG+L +  +    + ++G+   S   +Y  I   L   Q  ++LE++H   G V SS  +   QV  R  +++ +      +Q +  +    + W+  EIVRY +Y   LLK     + W RY++++ LYP+G   E   I  A+P +  SK F+  LPNA NI FD+  FL++    Y+P+    F  L   M  QRK+ +G
Sbjct:   44 WLILYNTVMTAGWLVLAVS----MARYGLAKGSNRGLYRSIEKTLKIFQTGALLEVVHCATGIVPSSAVLTAFQVSSRVFLVWAVTDSVKPVQNEYSVLIYLSAWTLTEIVRYSFYTFSLLKYLPRAIKWARYTLFIVLYPLGVTGELLTIYHALPHVYRSKLFAYPLPNALNISFDYYYFLIIVMISYVPI----FPQLYFHMMSQRKKVLG 248

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Sea Lamprey
Match: ptges3b (prostaglandin E synthase 3b (cytosolic) [Source:ZFIN;Acc:ZDB-GENE-040625-144])

HSP 1 Score: 50.447 bits (119), Expect = 9.749e-8
Identity = 36/109 (33.03%), Postives = 52/109 (47.71%), Query Frame = 1

Query:   97 WGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKD-PWPRLTSQPMKLPWLKCDFNNF--FFDESD 414
            W   K+Y+ L   I ++K+V V      L FS  G   S  + Y  E + +  ++P     K  +  I   +KK      WPRLT +  KL WL  DF+N+  + DESD
Sbjct:   16 WYDRKEYVFLDFCIEDSKDVAVKFESGKLLFSCVG--GSDKEKYHNEAELFEQIIPEDCKHKRTDRTIHCLMKKSKSGVAWPRLTKEKSKLKWLSVDFDNWKDWEDESD 122

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Yeast
Match: PHS1 (Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking [Source:SGD;Acc:S000003633])

HSP 1 Score: 62.3882 bits (150), Expect = 1.183e-11
Identity = 65/218 (29.82%), Postives = 109/218 (50.00%), Query Frame = 1

Query:  514 KDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCI--VVPH-SNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIA--FLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQ 1152
            K +  PL+ +L +YNL    G+ Y+      ++  +   G+   +   ++    VQ  +++EI+++++G V+S       QV  R LV+  I  ++P+ S +Q+   I  L A WS  EIVRY YY  +L+ +N A   L  LRY+++  LYP G  +E ++I  A+       Q+S+            +  +L YIP    GF  L + M  QRK+
Sbjct:    3 KKLASPLS-FLPLYNLLSAVGWSYLL---YLVISLYPKVGQPAFFYQTKNVATLVQCGAIIEIINSFLGVVRSPLLTTVAQVSSRLLVVLGIFQLLPNTSGVQSVVYISLLLA-WSITEIVRYLYYFFMLVFKNGAPKILILLRYNLFWILYPTGVASELRIIYCALN--AAESQYSLLYKRI------LIAAMLAYIP----GFPMLFLHMVAQRKK 203

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Nematostella
Match: EDO32410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SV55])

HSP 1 Score: 216.853 bits (551), Expect = 7.791e-66
Identity = 124/346 (35.84%), Postives = 196/346 (56.65%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDP--WPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKD----LTESLTEDDFIESEKLFKDVTKPLN-LYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKI---YPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYI 1092
            PIV W Q+K+ + L++++ + +   +++ E  L F G G GA G  NY  E  +  P+ P  SS K+ E ++E  + K+      W RL     +  WLK +F+ +  +E D   ++     +  ++     + + L  D  +  +++ +DV + L   YL+ YN  Q+  +LY+      I+ +  MEGK  +   Y  + D + + QL + LE+L+  +G VK+     F QVFGRNLVLF +VVPH  L  DP +  L  TWS +EI+RYP+Y++ ++      L WLRY+ W+PLYP+G +TE  LI KA+PLL ++++FSI LPNAFN  F F +FL  Y+
Sbjct:    7 PIVRWAQTKERLYLTLELSDVQYPSIDLTESRLLFKGYGHGAKGEDNYELEVNFLEPINPGESSHKVMERYVEFSIAKQKGREFFWQRLVDSEKRPNWLKINFDRWK-NEDDTEDEKQEAEEEQKRQISNIIVEQRLKRDYDMHGDRVKQDVVRFLKKFYLVTYNGIQFILFLYIVAK---IISRFIMEGKDSLAGNYDAVSDIIASCQLAAFLEVLNPAIGIVKTGVFAPFAQVFGRNLVLFMVVVPHPTLHADPVVSALFFTWSVIEIIRYPFYIVQIIGIPFEPLIWLRYTAWIPLYPVGMITEVILIWKALPLLDQTQRFSIILPNAFNFSFSFAMFLRFYL 348

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Nematostella
Match: EDO30588 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T0D0])

HSP 1 Score: 87.8113 bits (216), Expect = 6.365e-20
Identity = 69/222 (31.08%), Postives = 111/222 (50.00%), Query Frame = 1

Query:  538 LYLLMYNLFQYAGY--LYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFL----LLYIPLATIGFYYLMMRMYGQRKQKIG--PIVKKD 1179
            LYL++YN     G+  + V G+  W+  +HG      ++  I   L   Q  +++E+ H  +G+V+SS  +   QV  R  +++ I+     +Q    +    A WS  E++RY +Y+  L+      L W RY+ +  LYPIG   E   I  ++P +Q+S  +S+ LPN  N+ F +  FL    L YIP+    F  L   M GQR++ +   P  KKD
Sbjct:    2 LYLVLYNAVLCLGWSIVLVLGSLHWL--RHGTH--VGLFSAISIPLYIFQTAAIMEVFHCAVGFVRSSVFLTGFQVASRLFLVWAILYSVPEVQDSIGVAAAVAAWSVTEVIRYLFYVCSLVSVLPYALQWCRYTFFFFLYPIGVTGELVAIYASLPFVQKSGIYSVALPNPLNVGFSYYFFLIAVMLSYIPI----FPQLYFHMIGQRRKVLSSEPRGKKD 215

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Match: hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;Acc:101163569])

HSP 1 Score: 169.088 bits (427), Expect = 2.682e-47
Identity = 107/352 (30.40%), Postives = 174/352 (49.43%), Query Frame = 1

Query:   85 PIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSF--------SGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFY 1116
            P+V+W Q  + I L +++ +A+     +  ++L+F        S  G GA G   Y F  ++  PV P  S +K  +  + V + KE +  W RL +Q  K  +L  DF+ +  +ESD   +   K  + N+   +  L E  FI  +  F          L  YNL Q+ G+ ++F      L+  G +     +  I D +   Q ++ +E+L+A  G V++     F+QV GRN +LF I      +   P +F++   WS +EI RYP+Y+L         LTWLRY++W+PLYP+G + E   +L+A+P+  ++K FSI LP A      F   L  Y+ L  +G +
Sbjct:    5 PLVYWAQRHEEIYLRVELTDAQ-----VKTQSLTFFFLCVINCSARGHGAKGQNEYEFSLEFLFPVKPEVS-YKSTQRQVNVVVGKEKRGWWERLVTQERKPVFLAPDFDRWL-EESDAEMEIREKEERRNRLR-SARLKEPGFISLKTGF----------LFAYNLVQFLGFSWIFVNMTVRLFIFGKDSLYDTFHTISDVMFFCQTLAAVEVLNAAFGVVRTGVVPTFIQVIGRNFILFIIFGSLDEMHNRPVVFFVFYLWSAIEIFRYPFYMLGCFNTEWKTLTWLRYTVWIPLYPLGVLAEAVAVLQAIPIFDKNKLFSIPLPKAIGGSLSFSYVLQGYLILMFLGLF 338

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Match: ENSORLT00000000008.2 (very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase [Source:NCBI gene;Acc:101155409])

HSP 1 Score: 167.162 bits (422), Expect = 1.164e-46
Identity = 107/360 (29.72%), Postives = 187/360 (51.94%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEEN-LSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSD-ESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSS--PAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMY 1137
            M    P V+W Q    I L +++ +AKN+ +++ + N L F   G GA G   Y F  ++  PV P     K  +  +++K++K+    W RLT Q  K  +L  DF+ +  DESD  ++ ++ +  K +K +          +ES   +  + K    YL MYNL Q+ G+ ++F      L+  G +     +    D +   Q+++V E+++  +G VK+   PAM+  QV GRN+VLF I      +Q+   +F++   WS +EI RYP+Y+L  +      LTWLRY++W+PLYP+  + E   +++++P+  +++ FS+ LP        F   L +Y+ L  +G +  +  +Y
Sbjct:    1 MQILTPHVYWAQRHGEIFLRVELSDAKNLDISLNQNNTLHFRALGHGAKGDNEYKFSLEFLEPVRPEIDH-KSTQRQVDIKIRKQRVRWWDRLTLQEKKPLFLAPDFDRWL-DESDAETELQAQEEQKISKIN----------VESRVPYLGLKKG---YLFMYNLVQFLGFSWIFVNMTVRLFILGQDSFYDTFHTTADMMYFCQILAVFEVVNPLLGLVKTGLYPAMI--QVAGRNVVLFVIFGCLEEMQSRSIVFFVFYAWSSIEIFRYPFYMLAYIDTEWQLLTWLRYNLWIPLYPLAVLAEAVAVIQSLPIFDDTRLFSLPLPGFRGRSLSFSYTLQIYLVLMFLGLFINLRHLY 343

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Match: hacd3 (3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;Acc:101163569])

HSP 1 Score: 147.517 bits (371), Expect = 2.613e-39
Identity = 100/337 (29.67%), Postives = 155/337 (45.99%), Query Frame = 1

Query:  190 SGEGEGASGLKNYGFEFKYYLPVLP-----------NSS-----------------SWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFY 1116
            S  G GA G   Y F  ++  PV P           N S                 S+K  +  + V + KE +  W RL +Q  K  +L  DF+ +  +ESD   +   K  + N+   +  L E  FI  +  F          L  YNL Q+ G+ ++F      L+  G +     +  I D +   Q ++ +E+L+A  G V++     F+QV GRN +LF I      +   P +F++   WS +EI RYP+Y+L         LTWLRY++W+PLYP+G + E   +L+A+P+  ++K FSI LP A      F   L  Y+ L  +G +
Sbjct:   23 SARGHGAKGQNEYEFSLEFLFPVKPEVCVLLKCLNFNDSFPLSLFCIFIACIYTQVSYKSTQRQVNVVVGKEKRGWWERLVTQERKPVFLAPDFDRWL-EESDAEMEIREKEERRNRLR-SARLKEPGFISLKTGF----------LFAYNLVQFLGFSWIFVNMTVRLFIFGKDSLYDTFHTISDVMFFCQTLAAVEVLNAAFGVVRTGVVPTFIQVIGRNFILFIIFGSLDEMHNRPVVFFVFYLWSAIEIFRYPFYMLGCFNTEWKTLTWLRYTVWIPLYPLGVLAEAVAVLQAIPIFDKNKLFSIPLPKAIGGSLSFSYVLQGYLILMFLGLF 347

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Match: hacd2 (3-hydroxyacyl-CoA dehydratase 2 [Source:NCBI gene;Acc:101174470])

HSP 1 Score: 98.5969 bits (244), Expect = 6.253e-23
Identity = 66/211 (31.28%), Postives = 103/211 (48.82%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLL----YIPLATIGFYYLMMRMYGQRKQKIG 1161
            YL++YN+   AG+L +    +      G      +Y  I   L   Q  ++LEILH  +G V SS  +   QV  R  + + +      +Q++  +      W+  EI+RY +Y   LL      + W RY+ ++ LYP+G   E   I  A+P +Q++  +S+ LPN +N  FD+  FL+L    YIPL    F  L   M  QRK+ +G
Sbjct:   31 YLVIYNVVMTAGWLVIAVGLVRAYVARG--SYHGLYYSIEKPLKFFQTGALLEILHCAVGIVPSSVVLTGFQVLSRVFLTWAVTHSVREVQSEDSVLLFVTAWTVTEIIRYSFYTFSLLNHLPYLIKWARYTFFILLYPMGVTGELLTIYAALPYVQKTGLYSVTLPNKYNFSFDYYTFLILIMISYIPL----FPQLYFHMLRQRKKVLG 235

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Match: hacd1 (3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;Acc:101162008])

HSP 1 Score: 92.4337 bits (228), Expect = 1.664e-20
Identity = 64/212 (30.19%), Postives = 103/212 (48.58%), Query Frame = 1

Query:  481 EDDFIES-EKLFKDVTKP--LNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDF----VIFLLLYIP 1095
            ED  +E  E   K  TK      +L  YN+   AG+L +  A L    K G      +Y  I   L   Q  +++E+ H  +G V++S  +  +QV  R  +++ +      +Q +  +      W+  EI RY YY   LL     F+ W RY+ ++ LYP+G + E   I  A+P ++ S  +S+ LPN +N+ FD+    +I +L YIP
Sbjct:    6 EDGTVEEKENNNKKRTKSALTTAWLTFYNIAMTAGWLVLAMAMLRFYIKKGTH--KGLYRSIARTLKFFQTFALVEVGHCAIGIVRTSVIVTGVQVCSRIFMVWLVASSIRQIQNEESVILFLVVWTVTEITRYSYYTFKLLNHLPYFVKWARYNFFIVLYPLGVIGELLSIYAALPFVRRSGMYSMRLPNKYNVSFDYYYCLIIVMLSYIP 215

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Planmine SMEST
Match: SMESG000034959.1 (SMESG000034959.1)

HSP 1 Score: 798.89 bits (2062), Expect = 0.000e+0
Identity = 407/408 (99.75%), Postives = 407/408 (99.75%), Query Frame = 1

Query:   70 MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYLVDTLGXXXXXXXXXXXXXXIQNNSKYSK 1293
            MT FHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYLVDTLGKKKPTKSATKPAKSIQNNSKYSK
Sbjct:    1 MTGFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGLKNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLPWLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKDVTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYYLMMRMYGQRKQKIGPIVKKDWSNYNFLQYLVDTLGKKKPTKSATKPAKSIQNNSKYSK 408

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Planmine SMEST
Match: SMESG000023255.1 (SMESG000023255.1)

HSP 1 Score: 77.0258 bits (188), Expect = 8.223e-16
Identity = 73/213 (34.27%), Postives = 108/213 (50.70%), Query Frame = 1

Query:  541 YLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQLITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLF--CIVVPHSNLQTDPEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFMTEGKLILKAMPLLQESKQFSIFLPNAFNIQ--FDFVIFLLL--YIPLATIGFYYLMMRMYGQRKQKIG 1161
            YL +YNL    G+ YV    ++ L+        + Y  I   L  VQ  +VLEILH+  G+VKS   +  +QV  R  +++  C + P    +T     ++ A WS  EI+RY YY   L+      L WLRY+++  LYP+G   E   IL++      +  F I LPN+ NIQ  +DF++ L+L  Y P+    F  L   M  QRK+ +G
Sbjct:    7 YLFIYNLTLTCGWAYVLYKEIYALWSTKFN-LVETYSIIEKPLKLVQTAAVLEILHSAFGFVKSRVDITTIQVSSRLFLVWGICNIFPKIISETYGIPMFIIA-WSIAEIIRYGYYANHLINCVPYPLVWLRYTLFYVLYPMGVTGEVLAILESFRNAYGTTSF-IDLPNSLNIQMRYDFILVLVLVSYFPI----FPQLFGHMIVQRKKILG 212

[Close]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Planmine SMEST
Match: SMESG000068003.1 (SMESG000068003.1)

HSP 1 Score: 60.077 bits (144), Expect = 1.952e-10
Identity = 39/107 (36.45%), Postives = 55/107 (51.40%), Query Frame = 1

Query:   79 FHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGL--KNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLP-WLKCDFN 390
             HP V W Q KDY+ ++I I + K+ V+N+ EE+ SFS    G SG+  K+Y   F ++  V    S     +  I + +KK     WP L  +    P WLK DFN
Sbjct:    9 MHPTVLWAQRKDYLYITICIGDIKDKVMNLKEESFSFS----GISGIPPKHYEVNFDFHSKVHTEDSKQISTDREIVLLIKKSTSGYWPSLIKKSGPKPHWLKTDFN 111

The following BLAST results are available for this feature:

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Celegans
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Fly
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Sea Lamprey
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Yeast
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Nematostella
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Planmine SMEST

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
HACD3	5.073e-50	29.51	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbo...	[more]
HACD3	8.712e-46	29.86	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbo...	[more]
HACD3	3.555e-45	29.60	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbo...	[more]
HACD3	3.837e-34	31.88	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbo...	[more]
HACD3	3.837e-34	31.88	3-hydroxyacyl-CoA dehydratase 3 [Source:HGNC Symbo...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
hpo-8	3.396e-18	30.73	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
hpo-8	3.396e-18	30.73	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
R10E4.9	2.368e-8	34.21	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Hacd2	4.104e-75	34.25	gene:FBgn0032524 transcript:FBtr0080519	[more]
Hacd1	7.232e-21	31.08	gene:FBgn0032394 transcript:FBtr0080313	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hacd3	3.657e-58	31.56	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
hacd3	3.657e-58	31.56	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
hacd3	1.753e-53	30.77	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
hacd2	5.951e-24	32.33	3-hydroxyacyl-CoA dehydratase 2 [Source:ZFIN;Acc:Z...	[more]
hacd2	1.719e-21	31.73	3-hydroxyacyl-CoA dehydratase 2 [Source:ZFIN;Acc:Z...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
lrp12	2.916e-46	31.50	LDL receptor related protein 12 [Source:Xenbase;Ac...	[more]
lrp12	3.440e-46	30.31	LDL receptor related protein 12 [Source:Xenbase;Ac...	[more]
lrp12	7.773e-43	32.12	LDL receptor related protein 12 [Source:Xenbase;Ac...	[more]
HACD1	9.721e-23	29.39	3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;...	[more]
kif2a	2.647e-21	29.95	kinesin heavy chain member 2A [Source:Xenbase;Acc:...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Hacd3	1.684e-49	28.69	3-hydroxyacyl-CoA dehydratase 3 [Source:MGI Symbol...	[more]
Hacd1	4.591e-22	30.59	3-hydroxyacyl-CoA dehydratase 1 [Source:MGI Symbol...	[more]
Hacd1	4.591e-22	30.59	3-hydroxyacyl-CoA dehydratase 1 [Source:MGI Symbol...	[more]
Hacd2	9.690e-22	30.77	3-hydroxyacyl-CoA dehydratase 2 [Source:MGI Symbol...	[more]
Hacd4	2.926e-20	27.32	3-hydroxyacyl-CoA dehydratase 4 [Source:MGI Symbol...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q7SY06\|HACD3_DANRE	2.761e-57	31.56	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
sp\|Q5ZM57\|HACD3_CHICK	2.458e-53	31.25	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
sp\|A7YY55\|HACD3_BOVIN	2.724e-50	29.40	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
sp\|Q9P035\|HACD3_HUMAN	2.436e-49	29.51	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
sp\|Q8K2C9\|HACD3_MOUSE	1.178e-48	28.69	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G4VGD4	4.495e-100	40.57	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
A0A183R4F5	1.760e-98	41.13	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
A0A4S2MFA3	2.028e-97	42.13	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
A0A4S2MAZ7	2.364e-97	42.13	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
A0A419Q398	1.590e-96	42.89	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hacd3	1.020e-55	32.29	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
hacd2	3.351e-23	32.08	3-hydroxyacyl-CoA dehydratase 2 [Source:NCBI gene;...	[more]
hacd1	2.932e-21	29.68	3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;...	[more]
ENSAMXT00000037901.1	2.017e-20	29.61	pep primary_assembly:Astyanax_mexicanus-2.0:5:1308...	[more]
hacd1	1.540e-19	29.10	3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
si:ch73-41h24.1	4.829e-23	30.26	3-hydroxyacyl-CoA dehydratase 4 [Source:HGNC Symbo...	[more]
hacd1	4.943e-22	30.99	3-hydroxyacyl-CoA dehydratase 1 [Source:ZFIN;Acc:Z...	[more]
ptges3b	9.749e-8	33.03	prostaglandin E synthase 3b (cytosolic) [Source:ZF...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
PHS1	1.183e-11	29.82	Essential 3-hydroxyacyl-CoA dehydratase of the ER ...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO32410	7.791e-66	35.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO30588	6.365e-20	31.08	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hacd3	2.682e-47	30.40	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
ENSORLT00000000008.2	1.164e-46	29.72	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase...	[more]
hacd3	2.613e-39	29.67	3-hydroxyacyl-CoA dehydratase 3 [Source:NCBI gene;...	[more]
hacd2	6.253e-23	31.28	3-hydroxyacyl-CoA dehydratase 2 [Source:NCBI gene;...	[more]
hacd1	1.664e-20	30.19	3-hydroxyacyl-CoA dehydratase 1 [Source:NCBI gene;...	[more]

BLAST of Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000034959.1	0.000e+0	99.75	SMESG000034959.1	[more]
SMESG000023255.1	8.223e-16	34.27	SMESG000023255.1	[more]
SMESG000068003.1	1.952e-10	36.45	SMESG000068003.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30020430 ID=SMED30020430|Name=Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase|organism=Schmidtea mediterranea sexual|type=transcript|length=1560bp
TTCAATTGTTAATTTGATTTGAAATTCTATTTTAACGTAAAATTTTGGTG
TGATATATAAGAATTATTTATGACAGCATTTCACCCTATTGTATTTTGGG
GACAATCAAAGGACTATATTTTATTGAGTATTAAAATTATCAATGCAAAA
AATGTAGTCGTAAATATTGCTGAGGAAAATCTCAGTTTTAGTGGTGAAGG
TGAAGGAGCAAGTGGTCTAAAAAATTATGGATTTGAATTTAAATATTATC
TACCAGTTCTTCCTAATTCAAGTAGTTGGAAAATTAAAGAAAACTTCATC
GAAGTTAAATTAAAAAAAGAACTTAAAGATCCATGGCCTAGATTAACATC
TCAGCCGATGAAATTACCTTGGCTAAAATGTGATTTTAATAATTTCTTTT
TCGATGAAAGTGATTACGGTTCTGATGAGTCTGTAAAGCATAATAAGCCT
AATAAAAAAGATTTAACCGAATCGTTAACTGAAGATGATTTTATAGAATC
CGAAAAATTATTTAAAGATGTTACGAAACCGTTAAATCTCTATCTTTTAA
TGTATAACTTATTCCAATATGCCGGATACCTTTATGTATTTGGTGCTTGC
CTATGGATATTATACAAGCACGGAATGGAAGGTAAATCCAAAATATATCC
CTACATTCGTGATCAGCTTATAACTGTACAATTGGTTTCCGTTCTTGAGA
TATTGCATGCTTACATGGGCTGGGTTAAATCGTCACCAGCTATGGTGTTC
ATGCAGGTTTTTGGCAGAAATCTGGTGTTGTTTTGTATTGTTGTTCCACA
TTCTAATTTACAAACCGACCCAGAGATTTTCTGGCTTGCAGCAACTTGGA
GCTGTGTTGAAATAGTTAGATATCCTTATTATTTGCTTATTCTTCTTAAA
GAAAACATCGCTTTTTTAACTTGGTTGCGCTACTCAATTTGGGTTCCTCT
CTATCCGATTGGATTTATGACCGAAGGAAAATTGATTTTAAAAGCAATGC
CATTGTTACAAGAGTCGAAACAGTTTTCAATATTTTTACCCAATGCTTTT
AATATTCAATTTGACTTTGTCATATTCTTGCTTCTTTACATTCCTCTGGC
TACCATAGGTTTTTATTATTTAATGATGCGCATGTATGGGCAAAGAAAAC
AGAAAATAGGACCCATTGTGAAGAAGGATTGGAGTAATTACAATTTTCTC
CAGTATCTTGTCGATACTCTAGGTAAAAAGAAACCGACTAAGTCAGCGAC
GAAACCAGCAAAATCCATACAAAATAACAGCAAATACAGTAAGAAGGAAA
TTATTGAAAATAAATTAGAATAAAATGAGCTTTAAATGTTCATTATTAGC
ATGTTTGTGTGTATGTGTGTGTAATTGTTTGTTTTAATGATGGATTTCAC
ATATTATATTGTCATTAGTATTTTTTCGCTGTTCTTACATTTGATTGGAT
TTGCTTAAATATTGATTTATATTTTAAATGGTTTAATCAATTTAGATTTT
TAAATACATCAATATTTATTTTAAAATTGTTTTTATTGAATAAAAATCTT
TAATCTTGAA

protein sequence of SMED30020430-orf-1

>SMED30020430-orf-1 ID=SMED30020430-orf-1|Name=SMED30020430-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=418bp
MTAFHPIVFWGQSKDYILLSIKIINAKNVVVNIAEENLSFSGEGEGASGL
KNYGFEFKYYLPVLPNSSSWKIKENFIEVKLKKELKDPWPRLTSQPMKLP
WLKCDFNNFFFDESDYGSDESVKHNKPNKKDLTESLTEDDFIESEKLFKD
VTKPLNLYLLMYNLFQYAGYLYVFGACLWILYKHGMEGKSKIYPYIRDQL
ITVQLVSVLEILHAYMGWVKSSPAMVFMQVFGRNLVLFCIVVPHSNLQTD
PEIFWLAATWSCVEIVRYPYYLLILLKENIAFLTWLRYSIWVPLYPIGFM
TEGKLILKAMPLLQESKQFSIFLPNAFNIQFDFVIFLLLYIPLATIGFYY
LMMRMYGQRKQKIGPIVKKDWSNYNFLQYLVDTLGKKKPTKSATKPAKSI
QNNSKYSKKEIIENKLE*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR007052	CS_dom
IPR008978	HSP20-like_chaperone
IPR007482	Tyr_Pase-like_PTPLA

Vocabulary: **cellular component**
Term	Definition
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **biological process**
Term	Definition
GO:0006629	lipid metabolic process
GO:0006631	fatty acid metabolic process
GO:0006633	fatty acid biosynthetic process

Vocabulary: **molecular function**
Term	Definition
GO:0016829	lyase activity
GO:0102344	3-hydroxy-behenoyl-CoA dehydratase activity
GO:0102345	3-hydroxy-lignoceroyl-CoA dehydratase activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR007482	Protein-tyrosine phosphatase-like, PTPLA	PFAM	PF04387	PTPLA	coord: 204..364 e-value: 1.8E-47 score: 161.1
IPR007482	Protein-tyrosine phosphatase-like, PTPLA	PANTHER	PTHR11035	PTPLA DOMAIN PROTEIN	coord: 127..366
IPR007052	CS domain	PFAM	PF04969	CS	coord: 10..83 e-value: 4.0E-5 score: 24.6
IPR007052	CS domain	PROSITE	PS51203	CS	coord: 3..93 score: 15.574
IPR008978	HSP20-like chaperone	GENE3D	G3DSA:2.60.40.790		coord: 4..126 e-value: 3.6E-24 score: 87.6
IPR008978	HSP20-like chaperone	SUPERFAMILY	SSF49764	HSP20-like chaperones	coord: 4..110
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 388..417
None	No IPR available	PANTHER	PTHR11035:SF35	VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE	coord: 127..366
None	No IPR available	CDD	cd06465	p23_hB-ind1_like	coord: 6..115 e-value: 1.37055E-29 score: 108.836
None	No IPR available	TMHMM	TMhelix		coord: 158..180
None	No IPR available	TMHMM	TMhelix		coord: 282..301
None	No IPR available	TMHMM	TMhelix		coord: 329..351
None	No IPR available	TMHMM	TMhelix		coord: 253..275
None	No IPR available	TMHMM	TMhelix		coord: 200..219