Cystinosin homolog-like Protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020423 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518]) HSP 1 Score: 102.449 bits (254), Expect = 3.206e-25 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 33 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYR 107
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518]) HSP 1 Score: 103.219 bits (256), Expect = 6.691e-24 Identity = 49/93 (52.69%), Postives = 63/93 (67.74%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRS 2004 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR + A + LR Sbjct: 137 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYRKRPGLQAARTGSGSRLRQ 229
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518]) HSP 1 Score: 102.064 bits (253), Expect = 7.076e-24 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 137 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYR 211
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518]) HSP 1 Score: 102.834 bits (255), Expect = 7.568e-23 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 284 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYR 358
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Match: CTNS (cystinosin, lysosomal cystine transporter [Source:HGNC Symbol;Acc:HGNC:2518]) HSP 1 Score: 102.834 bits (255), Expect = 7.568e-23 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 284 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYR 358
BLAST of Cystinosin homolog-like Protein vs. Ensembl Celegans
Match: ctns-1 (Cystinosin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q09500]) HSP 1 Score: 116.701 bits (291), Expect = 6.076e-28 Identity = 54/78 (69.23%), Postives = 63/78 (80.77%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A NY RKSTVGWSIGNI LDFTGG L I+QMI+ + N NDW +F+A+P KFGLG SIFFDI+F+VQHYVLY AE Sbjct: 286 QAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQAVNVNDWSAFYANPVKFGLGFVSIFFDIIFMVQHYVLYPNAE 363
BLAST of Cystinosin homolog-like Protein vs. Ensembl Celegans
Match: ctns-1 (Cystinosin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q09500]) HSP 1 Score: 116.701 bits (291), Expect = 9.215e-28 Identity = 54/78 (69.23%), Postives = 63/78 (80.77%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A NY RKSTVGWSIGNI LDFTGG L I+QMI+ + N NDW +F+A+P KFGLG SIFFDI+F+VQHYVLY AE Sbjct: 286 QAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQAVNVNDWSAFYANPVKFGLGFVSIFFDIIFMVQHYVLYPNAE 363
BLAST of Cystinosin homolog-like Protein vs. Ensembl Fly
Match: CG17119 (gene:FBgn0039045 transcript:FBtr0084357) HSP 1 Score: 117.087 bits (292), Expect = 8.125e-28 Identity = 52/78 (66.67%), Postives = 65/78 (83.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A+MNYRRKST GWSIGNI LDFTGG LS++QMI+ ++N +DW S F DPTKFGLGLFS+ FD+ F++QHYV YR + Sbjct: 289 QALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTKFGLGLFSVLFDVFFMLQHYVFYRHSR 366
BLAST of Cystinosin homolog-like Protein vs. Ensembl Fly
Match: CG17119 (gene:FBgn0039045 transcript:FBtr0344299) HSP 1 Score: 117.087 bits (292), Expect = 8.125e-28 Identity = 52/78 (66.67%), Postives = 65/78 (83.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A+MNYRRKST GWSIGNI LDFTGG LS++QMI+ ++N +DW S F DPTKFGLGLFS+ FD+ F++QHYV YR + Sbjct: 289 QALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTKFGLGLFSVLFDVFFMLQHYVFYRHSR 366
BLAST of Cystinosin homolog-like Protein vs. Ensembl Zebrafish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:ZFIN;Acc:ZDB-GENE-050522-352]) HSP 1 Score: 129.798 bits (325), Expect = 5.053e-32 Identity = 58/96 (60.42%), Postives = 73/96 (76.04%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSS 2013 +A MNYRRKST GWSIGN+ LDFTGG S++QM + +YNN+ WR F DPTKFGLG+FSIFFDILF++QHY LYR EP+ + E +D+ S + Sbjct: 289 QAHMNYRRKSTEGWSIGNVLLDFTGGSFSLIQMFLEAYNNDKWRFIFGDPTKFGLGVFSIFFDILFIIQHYCLYRNREPMYQDLDEQNDQHSSVKT 384
BLAST of Cystinosin homolog-like Protein vs. Ensembl Zebrafish
Match: CABZ01030006.1 (pep scaffold:GRCz11:KN150258.1:33006:36502:-1 gene:ENSDARG00000114113.1 transcript:ENSDART00000182402.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CABZ01030006.1) HSP 1 Score: 52.7582 bits (125), Expect = 7.717e-7 Identity = 29/74 (39.19%), Postives = 44/74 (59.46%), Query Frame = 3 Query: 633 FSSHYHHQSNGQIERQFRTLKNWISCLEEKQFKTLEEALPQIEFEINSTIQSSIKVSLAEVVYGRKVYKEHFKI 854 ++ YH Q+N ER RTLK+ I+ E KT + LP++ F +NS IQ SI ++ AE+ GRK++ K+ Sbjct: 127 LTTAYHPQTN-MTERVNRTLKSMIAGFVEDNHKTWDTYLPELRFALNSAIQESIGMTPAELHLGRKIHSPMDKL 199
BLAST of Cystinosin homolog-like Protein vs. Ensembl Xenopus
Match: klhl24 (kelch like family member 24 [Source:Xenbase;Acc:XB-GENE-1000313]) HSP 1 Score: 117.087 bits (292), Expect = 3.459e-27 Identity = 53/75 (70.67%), Postives = 62/75 (82.67%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+RRKST GWSIGN+ LDFTGG SIVQM I SYNN++W F DPTKFGLG+FSI FDI+F++QHY LYR Sbjct: 385 QAYMNFRRKSTEGWSIGNVLLDFTGGSFSIVQMFIQSYNNDEWNLIFGDPTKFGLGVFSIGFDIVFIIQHYCLYR 459
BLAST of Cystinosin homolog-like Protein vs. Ensembl Mouse
Match: Ctns (cystinosis, nephropathic [Source:MGI Symbol;Acc:MGI:1932872]) HSP 1 Score: 100.138 bits (248), Expect = 3.882e-22 Identity = 45/75 (60.00%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIG + LDFTGG S++QM + SYNN+ W F DPTKFGLG+F+IFFD++F +QH+ LYR Sbjct: 284 QAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDVVFFIQHFYLYR 358
BLAST of Cystinosin homolog-like Protein vs. Ensembl Mouse
Match: Ctns (cystinosis, nephropathic [Source:MGI Symbol;Acc:MGI:1932872]) HSP 1 Score: 100.138 bits (248), Expect = 3.882e-22 Identity = 45/75 (60.00%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIG + LDFTGG S++QM + SYNN+ W F DPTKFGLG+F+IFFD++F +QH+ LYR Sbjct: 284 QAYMNFYYKSTKGWSIGGVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFTIFFDVVFFIQHFYLYR 358
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Match: sp|Q9VCR7|CTNS_DROME (Cystinosin homolog OS=Drosophila melanogaster OX=7227 GN=CG17119 PE=1 SV=2) HSP 1 Score: 117.087 bits (292), Expect = 8.144e-27 Identity = 52/78 (66.67%), Postives = 65/78 (83.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A+MNYRRKST GWSIGNI LDFTGG LS++QMI+ ++N +DW S F DPTKFGLGLFS+ FD+ F++QHYV YR + Sbjct: 289 QALMNYRRKSTSGWSIGNILLDFTGGTLSMLQMILNAHNYDDWVSIFGDPTKFGLGLFSVLFDVFFMLQHYVFYRHSR 366
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Match: sp|Q09500|CTNS_CAEEL (Cystinosin homolog OS=Caenorhabditis elegans OX=6239 GN=ctns-1 PE=3 SV=2) HSP 1 Score: 116.701 bits (291), Expect = 1.172e-26 Identity = 54/78 (69.23%), Postives = 63/78 (80.77%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A NY RKSTVGWSIGNI LDFTGG L I+QMI+ + N NDW +F+A+P KFGLG SIFFDI+F+VQHYVLY AE Sbjct: 286 QAYFNYTRKSTVGWSIGNIMLDFTGGTLDILQMILQAVNVNDWSAFYANPVKFGLGFVSIFFDIIFMVQHYVLYPNAE 363
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Match: sp|A8WN56|CTNS_CAEBR (Cystinosin homolog OS=Caenorhabditis briggsae OX=6238 GN=ctns-1 PE=3 SV=1) HSP 1 Score: 114.39 bits (285), Expect = 7.544e-26 Identity = 51/78 (65.38%), Postives = 63/78 (80.77%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAE 1959 +A NY+RKSTVGWSIGNI LDFTGG L I+QM++ + N NDW +F+A+P KFGLG SIFFDI+F++QHY LY AE Sbjct: 285 QAYFNYQRKSTVGWSIGNILLDFTGGSLDILQMVLQAINVNDWSAFYANPVKFGLGFVSIFFDIIFMIQHYALYPDAE 362
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Match: sp|A7MB63|CTNS_BOVIN (Cystinosin OS=Bos taurus OX=9913 GN=CTNS PE=2 SV=1) HSP 1 Score: 103.99 bits (258), Expect = 1.204e-22 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 284 QAYMNFHYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGIFSIIFDVVFFIQHFCLYR 358
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Match: sp|O60931|CTNS_HUMAN (Cystinosin OS=Homo sapiens OX=9606 GN=CTNS PE=1 SV=2) HSP 1 Score: 102.834 bits (255), Expect = 3.634e-22 Identity = 46/75 (61.33%), Postives = 58/75 (77.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MN+ KST GWSIGN+ LDFTGG S++QM + SYNN+ W F DPTKFGLG+FSI FD++F +QH+ LYR Sbjct: 284 QAYMNFYYKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDQWTLIFGDPTKFGLGVFSIVFDVVFFIQHFCLYR 358
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Match: A0A2S2NF29 (Cystinosin (Fragment) OS=Schizaphis graminum OX=13262 GN=g.117536 PE=4 SV=1) HSP 1 Score: 129.798 bits (325), Expect = 4.977e-31 Identity = 62/97 (63.92%), Postives = 72/97 (74.23%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSI 2016 + VMNY+RKST+GWSIGNIFLDFTGG LSI+QMII +YN NDW S F DPTKFGLGL S+ FDILF +QHYV Y G Y FEN +E+ + Sbjct: 57 QVVMNYKRKSTIGWSIGNIFLDFTGGLLSILQMIINAYNYNDWASVFGDPTKFGLGLLSVIFDILFFLQHYVFYSGVN---YTEFENYNEVEEDDEV 150
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Match: A0A2S2NG50 (Cystinosin OS=Schizaphis graminum OX=13262 GN=g.117526 PE=4 SV=1) HSP 1 Score: 126.331 bits (316), Expect = 1.662e-30 Identity = 61/94 (64.89%), Postives = 71/94 (75.53%), Query Frame = 1 Query: 1735 MNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSI 2016 MNY+RKST+GWSIGNIFLDFTGG LSI+QMII +YN NDW S F DPTKFGLGL S+ FDILF +QHYV Y G + Y FEN +E+ + Sbjct: 1 MNYKRKSTIGWSIGNIFLDFTGGLLSILQMIINAYNYNDWASVFGDPTKFGLGLLSVIFDILFFLQHYVFYSG---VNYTEFENYNEVEEDDEV 91
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Match: A0A0B6XXL7 (Uncharacterized protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF2887 PE=4 SV=1) HSP 1 Score: 125.946 bits (315), Expect = 3.702e-30 Identity = 59/93 (63.44%), Postives = 74/93 (79.57%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRS 2004 +A MN+RRKST+GWSIGN+ LD TGG LS++QM +LSYN++DW S F DPTKFGLGLFSI FDILF+VQHY LYRG P + ++ DE+ + Sbjct: 29 QAYMNFRRKSTLGWSIGNVLLDCTGGSLSLLQMFLLSYNSDDWGSIFGDPTKFGLGLFSILFDILFIVQHYCLYRGKVP-YEQIQDSSDEITA 120
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Match: A0A1J1HME6 (CLUMA_CG002366, isoform A OS=Clunio marinus OX=568069 GN=putative Cystinosin homolog PE=4 SV=1) HSP 1 Score: 131.724 bits (330), Expect = 2.794e-29 Identity = 62/90 (68.89%), Postives = 73/90 (81.11%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDE 1995 +AVMNYRRKSTVGWSIGNI LDFTGG LS++QMI+ SYN NDW+S F DPTKFGLGLFS+ FDI+F++QHYV YR P Y + + DE Sbjct: 292 QAVMNYRRKSTVGWSIGNIILDFTGGLLSMLQMILNSYNYNDWQSIFGDPTKFGLGLFSVLFDIVFMLQHYVFYRNLLP--YQLIPDSDE 379
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Match: A0A1L8DDP2 (Putative cystine transporter cystinosin (Fragment) OS=Nyssomyia neivai OX=330878 PE=4 SV=1) HSP 1 Score: 127.487 bits (319), Expect = 6.694e-29 Identity = 57/79 (72.15%), Postives = 69/79 (87.34%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEP 1962 +A+MNYRRKSTVGWSIGNI LDFTGG LS++QM++ +YN +DW S F DPTKFGLGLFS+ FDI+F++QHYVLYR A P Sbjct: 170 QALMNYRRKSTVGWSIGNILLDFTGGILSMLQMMLNAYNYDDWDSIFGDPTKFGLGLFSVAFDIVFIIQHYVLYRNATP 248
BLAST of Cystinosin homolog-like Protein vs. Ensembl Cavefish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:103043999]) HSP 1 Score: 121.709 bits (304), Expect = 2.050e-29 Identity = 54/89 (60.67%), Postives = 69/89 (77.53%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDD 1992 +A MNY+RKST GWSIGN+ LDFTGG S++QM + SYNN++W+ F DPTKFGLGLFSIFFD++F++QHY LYR P Y V ++ Sbjct: 289 QAYMNYKRKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDEWKLIFGDPTKFGLGLFSIFFDVIFIIQHYCLYRNKGP-EYQVLSTEE 376
BLAST of Cystinosin homolog-like Protein vs. Ensembl Cavefish
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:103043999]) HSP 1 Score: 121.709 bits (304), Expect = 2.050e-29 Identity = 54/89 (60.67%), Postives = 69/89 (77.53%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDD 1992 +A MNY+RKST GWSIGN+ LDFTGG S++QM + SYNN++W+ F DPTKFGLGLFSIFFD++F++QHY LYR P Y V ++ Sbjct: 289 QAYMNYKRKSTEGWSIGNVLLDFTGGSFSLLQMFLQSYNNDEWKLIFGDPTKFGLGLFSIFFDVIFIIQHYCLYRNKGP-EYQVLSTEE 376
BLAST of Cystinosin homolog-like Protein vs. Ensembl Nematostella
Match: EDO46894 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNQ1]) HSP 1 Score: 115.931 bits (289), Expect = 5.506e-29 Identity = 54/74 (72.97%), Postives = 62/74 (83.78%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLY 1947 +A MNYRRKSTVGWSIGN+ LDFTGG S++QM +L+YNN+DWRS F D TKFGLG SI FDILF+VQHY LY Sbjct: 179 QAYMNYRRKSTVGWSIGNVLLDFTGGSFSLLQMFLLAYNNDDWRSIFGDFTKFGLGFISIVFDILFIVQHYALY 252
BLAST of Cystinosin homolog-like Protein vs. Ensembl Nematostella
Match: EDO34987 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SMR9]) HSP 1 Score: 72.0182 bits (175), Expect = 6.038e-14 Identity = 37/95 (38.95%), Postives = 54/95 (56.84%), Query Frame = 1 Query: 1735 MNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSIK 2019 +NYRRK T G+ IG + LDF+GG LS++QM I + + F + K LG+ ++ F+I V+QHY+LY G P + A D T +K Sbjct: 170 LNYRRKCTEGFHIGGVLLDFSGGILSLLQMNIYCALEHSTKQFTGNIPKLVLGILTLVFNITLVLQHYMLYMGNPPPVLA----PDSTEKTDLMK 260
BLAST of Cystinosin homolog-like Protein vs. Ensembl Nematostella
Match: EDO31571 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXI3]) HSP 1 Score: 67.0106 bits (162), Expect = 6.717e-14 Identity = 31/71 (43.66%), Postives = 46/71 (64.79%), Query Frame = 1 Query: 1735 MNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLY 1947 +NYRRK T G+ IG + LDF+GG LS++QM I + + F + K LG+ ++ F+I V+QHY+LY Sbjct: 10 LNYRRKCTEGFHIGGVLLDFSGGILSLLQMNIYCALEHSTKQFTGNIPKLVLGILTLVFNITLVLQHYMLY 80
BLAST of Cystinosin homolog-like Protein vs. Ensembl Medaka
Match: ctns (cystinosin, lysosomal cystine transporter [Source:NCBI gene;Acc:101155673]) HSP 1 Score: 125.946 bits (315), Expect = 4.282e-30 Identity = 55/75 (73.33%), Postives = 64/75 (85.33%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYR 1950 +A MNYRRKST GWSIGN+ LDFTGG LSI+QMI+ SYNN++WR F DPTKFGLGLFS+ FDI+F+ QHY LYR Sbjct: 413 QAYMNYRRKSTEGWSIGNVLLDFTGGVLSILQMIVQSYNNDEWRLIFGDPTKFGLGLFSVLFDIIFITQHYCLYR 487
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Match: SMESG000079054.1 (SMESG000079054.1) HSP 1 Score: 200.675 bits (509), Expect = 9.894e-58 Identity = 97/98 (98.98%), Postives = 98/98 (100.00%), Query Frame = 1 Query: 1726 KAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSIK 2019 +AVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSIK Sbjct: 251 QAVMNYRRKSTVGWSIGNIFLDFTGGFLSIVQMIILSYNNNDWRSFFADPTKFGLGLFSIFFDILFVVQHYVLYRGAEPIIYAVFENDDELRSTSSIK 348
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Match: SMESG000080238.1 (SMESG000080238.1) HSP 1 Score: 164.851 bits (416), Expect = 3.485e-53 Identity = 86/112 (76.79%), Postives = 94/112 (83.93%), Query Frame = 3 Query: 633 FSSHYHHQSNGQIERQFRTLKNWISC-LEEKQFKTLEEALPQIEFEINSTIQSSIKVSLAEVVYGRKVYKEHFKIGTETNNKESRKNEILINIKSVNRINNYNQENRTHRSF 965 +S YHHQSN QIERQFRTL++WISC LEEK+FKT EEAL IEF I+ST+QSSIKVS AEVVY RK+ KE F TE NNKESRKNE+L NIKSVNRINNYNQENRTHRS Sbjct: 348 YSCPYHHQSNDQIERQFRTLRDWISCCLEEKEFKTWEEALHHIEFAISSTMQSSIKVSSAEVVYRRKLCKEFFTYDTEANNKESRKNEMLNNIKSVNRINNYNQENRTHRSL 459 HSP 2 Score: 64.3142 bits (155), Expect = 3.485e-53 Identity = 36/55 (65.45%), Postives = 40/55 (72.73%), Query Frame = 1 Query: 472 KAVRKQGEKTLFNNVLSSCILKFVPLKEIYFDKRKCFDSNSFRNRALKYQMKIFF 636 KAVR +KTL NNVLSS KF+ I+ DK KCFDSNS RN ALKYQMKIF+ Sbjct: 299 KAVRTPDKKTLVNNVLSS--WKFIL---IHVDKEKCFDSNSLRNMALKYQMKIFY 348
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Match: SMESG000034332.1 (SMESG000034332.1) HSP 1 Score: 157.147 bits (396), Expect = 7.165e-45 Identity = 86/120 (71.67%), Postives = 97/120 (80.83%), Query Frame = 3 Query: 780 IQSSIKVSLAEVVYGRKVYKEHFKIGTETNNKESRKNEILINIKSVNRINNYNQENRTHRSFCVGEFVLVREVVRNKKDNRYCGLF*IIEKD*KNYYLLKDLNGKFLKRNVE*LKPF*AR 1139 +QSSIKVS AEVVYGR++ KE F IG+E N SRKNEIL IKSVNRINNYNQENRTH SF VGE V V+E VRNK++NRYCG F +IEKD K+ YLLKDLN KF+KRNVE LK F A+ Sbjct: 1 MQSSIKVSPAEVVYGRRLCKERFTIGSEAKNNVSRKNEILNIIKSVNRINNYNQENRTHGSFSVGELVNVKEDVRNKQENRYCGPFELIEKDHKHSYLLKDLNRKFMKRNVEWLKQFKAK 120
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Match: SMESG000058507.1 (SMESG000058507.1) HSP 1 Score: 125.946 bits (315), Expect = 4.836e-40 Identity = 72/122 (59.02%), Postives = 83/122 (68.03%), Query Frame = 3 Query: 645 YHHQSNGQIERQFRTLKNWISCLEEKQFKTLEEALPQIEFEINSTIQSSIKVSLAEVVYGRKVYKEHFKIGTETNNKESRKNEILINIKSVNRINNYNQENRTHRSFCVGEFVLVREVVRNK 1010 + +QSNG+I CLEE QFKT EEAL I F INST+QSSI +S EVVY RK+ +HF I T+ NNKE R+NEIL NI+SVNRIN Y QENRTHRS VGE V +E RNK Sbjct: 166 FTNQSNGKI-----------CCLEENQFKTCEEALTHIGFAINSTMQSSINISTTEVVYRRKLCIKHFIIDTQPNNKELRRNEILNNIESVNRINIYYQENRTHRSLSVGELVFNKEDFRNK 276 HSP 2 Score: 58.9214 bits (141), Expect = 4.836e-40 Identity = 31/55 (56.36%), Postives = 38/55 (69.09%), Query Frame = 1 Query: 472 KAVRKQGEKTLFNNVLSSCILKFVPLKEIYFDKRKCFDSNSFRNRALKYQMKIFF 636 KA+R E+T +NVLSS ILKF KEI+ DKRKC D NS A+KYQ+K+ F Sbjct: 112 KALRTHDEETRVDNVLSSWILKFGSPKEIHVDKRKCSDFNSLSTIAIKYQIKMVF 166
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Match: SMESG000027570.1 (SMESG000027570.1) HSP 1 Score: 127.487 bits (319), Expect = 1.296e-34 Identity = 63/84 (75.00%), Postives = 72/84 (85.71%), Query Frame = 3 Query: 630 IFSSHYHHQSNGQIERQFRTLKNWISC-LEEKQFKTLEEALPQIEFEINSTIQSSIKVSLAEVVYGRKVYKEHFKIGTETNNKE 878 + SS +H+QSNGQIERQFRTL++WISC LEEKQFKT EEALP IEF INS++QSSIKVS AEVVYGRK+ KE F GTE NNK+ Sbjct: 12 VHSSPFHYQSNGQIERQFRTLRDWISCCLEEKQFKTWEEALPHIEFAINSSMQSSIKVSPAEVVYGRKLCKERFTYGTEANNKK 95 The following BLAST results are available for this feature:
BLAST of Cystinosin homolog-like Protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cystinosin homolog-like Protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 2
BLAST of Cystinosin homolog-like Protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of Cystinosin homolog-like Protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of Cystinosin homolog-like Protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 1
BLAST of Cystinosin homolog-like Protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of Cystinosin homolog-like Protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cystinosin homolog-like Protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cystinosin homolog-like Protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of Cystinosin homolog-like Protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Cystinosin homolog-like Protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Cystinosin homolog-like Protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Cystinosin homolog-like Protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Cystinosin homolog-like Protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020423 ID=SMED30020423|Name=Cystinosin homolog-like Protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2235bpback to top Annotated Terms
The following terms have been associated with this transcript:
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