DNA methyltransferase 1-associated protein

Overview
NameDNA methyltransferase 1-associated protein
Smed IDSMED30020379
Length (bp)2056
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of DNA methyltransferase 1-associated protein (SMED30020379) t-SNE clustered cells

Violin plots show distribution of expression levels for DNA methyltransferase 1-associated protein (SMED30020379) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of DNA methyltransferase 1-associated protein (SMED30020379) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for DNA methyltransferase 1-associated protein (SMED30020379) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30020379

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
neoblastSMED30020379h1SMcG0022381 dd_Smed_v4_6218_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30020379h1SMcG0022381 dd_Smed_v4_6218_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30020379h1SMcG0022381 dd_Smed_v4_6218_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Human
Match: HECA (hdc homolog, cell cycle regulator [Source:HGNC Symbol;Acc:HGNC:21041])

HSP 1 Score: 123.635 bits (309), Expect = 4.618e-29
Identity = 129/503 (25.65%), Postives = 194/503 (38.57%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRKF----------DHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD--NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFS-PQMKDFLPTTIKSQSQQNP--KPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  +VVC+N +C  S W+H  C   WE  I          ++  C+ R RS+         W +   +L  +   C C QG L+K           D       +        G+     +K  P +      Q G S   +   R++S+D  NS   +        RS   S  Q   +  T   +LSP  FS P+   +L   +K+     P  K +A G +        R  H   S  G        L      +++      R+ +       +P  K N + ++MEDD+  G  +D + F+L+ LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  VC++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ +                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:  112 DYQKVVCNNEHCPCSTWMHLQCFYEWESSI---------LVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPN----KPQKGPS---HDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQ---SPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVF-------RNAHFDYSPAG--------LAVHRGGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 537          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Celegans
Match: cri-1 (Conserved Regulator of Innate immunity [Source:UniProtKB/TrEMBL;Acc:P90912])

HSP 1 Score: 80.8777 bits (198), Expect = 3.269e-16
Identity = 60/235 (25.53%), Postives = 101/235 (42.98%), Query Frame = 1
Query: 1264 GNIFRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEIVICCQFCHRPW-TGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVK 1962
            G++F +R+D+NN    +P SK N   I+MEDD   G DD ++ LL  L    L  + C+ C  +L VYD  PLIDG F++SP+      +                                     +L  +C  C+     C       W  G   ++G+LY YDI ++  CC   ++C SC +     ++   D ++ +  N        N++ ++  + C +C   ++H V+
Sbjct:  139 GSVFHKRSDYNNLLSVIPRSKFNGIHIKMEDDCPQGGDDVRLCLLKSLGAHNLRAIPCVQCKDELKVYDKYPLIDGVFYISPVSQFGPKTEISL----------------------------DGRRFYLQQLCARCLWSDWSCKNCGKDEWFDGKSFVLGTLYYYDIVSSGRCCP--VVCQSCRQ-----SLGVRDQLATQLAN-------GNYATINEQMACQSCGVSNFHLVR 331          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Fly
Match: hdc (gene:FBgn0010113 transcript:FBtr0085621)

HSP 1 Score: 138.272 bits (347), Expect = 2.389e-33
Identity = 79/237 (33.33%), Postives = 122/237 (51.48%), Query Frame = 1
Query: 1270 IFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI----VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            IF +R DF++F  LP ++ N+Y +++ED+   GND+T++F+LS L+Q  ++ V C++C   L+V+D  PL+DG+FFLSP  HS  C                                 +    +L  VC++C+        I C+FC  PW G+ L++G++Y YDIFAA+PCC  R  CN+C ++ +                      LS +S  S  + C  C+T+D HFVKP 
Sbjct:  443 IFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKY----------------------------EGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQ-----------------QRLSFYSDYSHGVTCPYCNTQDTHFVKPL 634          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Fly
Match: hdc (gene:FBgn0010113 transcript:FBtr0085619)

HSP 1 Score: 135.576 bits (340), Expect = 5.931e-33
Identity = 79/237 (33.33%), Postives = 123/237 (51.90%), Query Frame = 1
Query: 1270 IFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI----VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            IF +R DF++F  LP ++ N+Y +++ED+   GND+T++F+LS L+Q  ++ V C++C   L+V+D  PL+DG+FFLSP  HS  C                             +   +    +L  VC++C+        I C+FC  PW G+ L++G++Y YDIFAA+PCC  R  CN+C ++ +                      LS +S  S  + C  C+T+D HFVKP 
Sbjct:  443 IFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCI----------------------------EVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQ-----------------QRLSFYSDYSHGVTCPYCNTQDTHFVKPL 634          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Fly
Match: hdc (gene:FBgn0010113 transcript:FBtr0330311)

HSP 1 Score: 135.576 bits (340), Expect = 5.931e-33
Identity = 79/237 (33.33%), Postives = 123/237 (51.90%), Query Frame = 1
Query: 1270 IFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI----VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            IF +R DF++F  LP ++ N+Y +++ED+   GND+T++F+LS L+Q  ++ V C++C   L+V+D  PL+DG+FFLSP  HS  C                             +   +    +L  VC++C+        I C+FC  PW G+ L++G++Y YDIFAA+PCC  R  CN+C ++ +                      LS +S  S  + C  C+T+D HFVKP 
Sbjct:  443 IFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCI----------------------------EVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQ-----------------QRLSFYSDYSHGVTCPYCNTQDTHFVKPL 634          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Fly
Match: hdc (gene:FBgn0010113 transcript:FBtr0085620)

HSP 1 Score: 110.923 bits (276), Expect = 1.462e-27
Identity = 69/214 (32.24%), Postives = 106/214 (49.53%), Query Frame = 1
Query: 1339 IQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI----VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            + +ED+   GND+T++F+LS L+Q  ++ V C++C   L+V+D  PL+DG+FFLSP  HS  C                             +   +    +L  VC++C+        I C+FC  PW G+ L++G++Y YDIFAA+PCC  R  CN+C ++ +                      LS +S  S  + C  C+T+D HFVKP 
Sbjct:   17 VGIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCI----------------------------EVKYEGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQ-----------------QRLSFYSDYSHGVTCPYCNTQDTHFVKPL 185          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Zebrafish
Match: heca (hdc homolog, cell cycle regulator [Source:ZFIN;Acc:ZDB-GENE-041001-173])

HSP 1 Score: 109.383 bits (272), Expect = 1.127e-24
Identity = 73/238 (30.67%), Postives = 105/238 (44.12%), Query Frame = 1
Query: 1273 FRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            F +R D +     +P  K N Y ++MEDD+  G  +D + F+LS LS    N V C +C   L +++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ V                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:  323 FLRRLDLSELLTHIPRHKLNTYHVRMEDDAQAGQGEDLRKFILSALSASHRNVVNCALCHHTLPIFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAICVDCLEGVHKIVCIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRVG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 517          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Xenopus
Match: heca (hdc homolog, cell cycle regulator [Source:NCBI gene;Acc:100038125])

HSP 1 Score: 128.257 bits (321), Expect = 1.152e-30
Identity = 129/500 (25.80%), Postives = 200/500 (40.00%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRK------FDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD--NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFS-PQMKDFLPTTIKSQSQQNP--KPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  +V+C+N +C  S W+H  C   WE  I          ++  C+ R RS+         W +   +L  +   C C QG L+K                 +      G++ S     +      V +Q G +F      R++S+D  NS   S    +   RS  +S  Q   +      VLSP+ F+ P+   +L   +K+     P  K +A    ++ S       H+  S  G  +      + L+ P        F +R D +     +P  K N + ++MEDD+  G  +D + F+LS LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ +                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:   92 DYQKVICNNEHCPYSTWMHLQCFYEWESSIL---------VQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSATEKPCGRSTSESSDDIKKCRGTVKSQKGLTF---DLPRRHSVDRQNSQEKSIGGGSHSLRSPCVSPGQ---SPPAGYPVLSPSHFNVPRSSRYLGEFLKNAVHLEPHKKSLATSGAIRNS-------HYDCSMPGLQT---HRSMRLDAPVQ------FLRRLDLSELLAHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILSALSASYRNVVNCALCHRTLPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYALCVDCLEGVHKIICIKCKSLWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 517          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Xenopus
Match: heca (hdc homolog, cell cycle regulator [Source:NCBI gene;Acc:100038125])

HSP 1 Score: 97.0561 bits (240), Expect = 1.478e-20
Identity = 110/434 (25.35%), Postives = 171/434 (39.40%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRK------FDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD--NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFS-PQMKDFLPTTIKSQSQQNP--KPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCC 1779
            D  +V+C+N +C  S W+H  C   WE  I          ++  C+ R RS+         W +   +L  +   C C QG L+K                 +      G++ S     +      V +Q G +F      R++S+D  NS   S    +   RS  +S  Q   +      VLSP+ F+ P+   +L   +K+     P  K +A    ++ S       H+  S  G  +      + L+ P        F +R D +     +P  K N + ++MEDD+  G  +D + F+LS LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC
Sbjct:   92 DYQKVICNNEHCPYSTWMHLQCFYEWESSI---------LVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSATEKPCGRSTSESSDDIKKCRGTVKSQKGLTF---DLPRRHSVDRQNSQEKSIGGGSHSLRSPCVSPGQ---SPPAGYPVLSPSHFNVPRSSRYLGEFLKNAVHLEPHKKSLATSGAIRNS-------HYDCSMPGLQT---HRSMRLDAPVQ------FLRRLDLSELLAHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILSALSASYRNVVNCALCHRTLPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYALCVDCLEGVHKIICIKCKSLWDGSWHQLGTMYTYDILAASPCC 468          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Mouse
Match: Heca (hdc homolog, cell cycle regulator [Source:MGI Symbol;Acc:MGI:2685715])

HSP 1 Score: 127.872 bits (320), Expect = 1.509e-30
Identity = 136/507 (26.82%), Postives = 200/507 (39.45%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRK-------------FDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD--NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFS-PQMKDFLPTTIKSQSQQNP--KPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  +VVC+N +C  S W+H  C   WE  I          ++  C+ R RS+         W +   +L  +   C C QG L+K                 SG   N A     AG+     R L          Q G   LN+   R++S+D  NS   +  +     RS   S  Q   +  T   +LSP  FS P+   +L   +K+     P  K V  G +        R  H   S  G         +S+++  +      F +R D +     +P  K N + ++MEDD+  G  +D + F+L+ LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  VC++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ +                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:  113 DYQKVVCNNEHCPCSTWMHLQCFYEWESSI---------LVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTARPPGEAGEEAKKGRALN-------KPQKG---LNHDLPRRHSMDRQNSQEKTVGSAAYGARSPCGSPGQ---SPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAVPGGHVF-------RNAHFDYSSAG---------LSVHRAGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 538          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Mouse
Match: Heca (hdc homolog, cell cycle regulator [Source:MGI Symbol;Acc:MGI:2685715])

HSP 1 Score: 69.3218 bits (168), Expect = 1.242e-13
Identity = 44/155 (28.39%), Postives = 69/155 (44.52%), Query Frame = 1
Query: 1327 NAYFIQMEDDSCTGN-DDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNV--VCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCC 1779
            N + ++MEDD+  G  +D + F+L+ LS    N V C +C   L V++  PL+DGT F                             S        +  P     + +++  VC++C+  +  I C  C   W G+   +G++YTYDI AA PCC
Sbjct:    2 NTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLF----------------------------LSPSRHDEIEYDVPCHLQGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCC 128          
BLAST of DNA methyltransferase 1-associated protein vs. UniProt/SwissProt
Match: sp|Q9N2M8|HDC_DROME (Headcase protein OS=Drosophila melanogaster OX=7227 GN=hdc PE=1 SV=2)

HSP 1 Score: 138.272 bits (347), Expect = 2.395e-32
Identity = 79/237 (33.33%), Postives = 122/237 (51.48%), Query Frame = 1
Query: 1270 IFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI----VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            IF +R DF++F  LP ++ N+Y +++ED+   GND+T++F+LS L+Q  ++ V C++C   L+V+D  PL+DG+FFLSP  HS  C                                 +    +L  VC++C+        I C+FC  PW G+ L++G++Y YDIFAA+PCC  R  CN+C ++ +                      LS +S  S  + C  C+T+D HFVKP 
Sbjct:  443 IFSRRLDFSSFNLLPKTRLNSYQVKIEDEGNHGNDETRLFILSSLAQSQMSRVACILCEEPLLVFDRYPLVDGSFFLSPKQHSSGCIEVKY----------------------------EGRTLYLTCVCMSCLDGTSSSRAINCRFCKEPWDGSSLVLGTMYAYDIFAAMPCCAERFKCNNCFKMLMHPQ-----------------QRLSFYSDYSHGVTCPYCNTQDTHFVKPL 634          
BLAST of DNA methyltransferase 1-associated protein vs. UniProt/SwissProt
Match: sp|Q9UBI9|HDC_HUMAN (Headcase protein homolog OS=Homo sapiens OX=9606 GN=HECA PE=1 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 2.218e-28
Identity = 129/503 (25.65%), Postives = 194/503 (38.57%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRKF----------DHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD--NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFS-PQMKDFLPTTIKSQSQQNP--KPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  +VVC+N +C  S W+H  C   WE  I          ++  C+ R RS+         W +   +L  +   C C QG L+K           D       +        G+     +K  P +      Q G S   +   R++S+D  NS   +        RS   S  Q   +  T   +LSP  FS P+   +L   +K+     P  K +A G +        R  H   S  G        L      +++      R+ +       +P  K N + ++MEDD+  G  +D + F+L+ LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  VC++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ +                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:  112 DYQKVVCNNEHCPCSTWMHLQCFYEWESSI---------LVQFNCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKKDTDWYQVKRMQDEKKKKSGSEKNTGRPPGEAAEEAKKCRPPN----KPQKGPS---HDLPRRHSMDRQNSQEKAVGAAAYGARSPGGSPGQ---SPPTGYSILSPAHFSGPRSSRYLGEFLKNAIHLEPHKKAMAGGHVF-------RNAHFDYSPAG--------LAVHRGGHFDTPVQFLRRLDLSELLTHIPRHKLNTFHVRMEDDAQVGQGEDLRKFILAALSASHRNVVNCALCHRALPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAVCVDCLEGVHKIICIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRIG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 537          
BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Match: A0A210QFT7 (Headcase protein-like OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT07713 PE=4 SV=1)

HSP 1 Score: 193.741 bits (491), Expect = 5.039e-50
Identity = 160/542 (29.52%), Postives = 239/542 (44.10%), Query Frame = 1
Query:  478 CCTPIGLKCCYDEEGKNRIHSDLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRK-FDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSH--------------MQVNNQSGSSFLNNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTD-GRVLSPTEFSPQMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQN-----RQRHHSASYHGSNSICKEE--------------LVSLNQPNYNLAG---------NIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEIV-ICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            CC P G   C +E        D  RVVC+N  C +  W+H  C   WE  + A  +KS  + R+   ++QR    W +   +L  K+  C C +G LRK  D+ S P  +NA       + N     +V +                ++  NQ+ +    N  N   S+  +++N+Y   T R R+ + S +  L N + +   +L+P    P     L       S+ N    AN +    S+P N     R R  S    GS+S+                  L+   +P ++            NIFR+R+D   F  LP  KQN Y I+MEDD   GND+T+ F+L+HLS   ++++ C++C   L V+D  P+IDGTFFLSP  +                                 Q  S    +F+N VC+NC+     + C  C R W G+ LL+GS+Y+YDIFAA+PCC  RL C  C R  +D+N                 + L+ +S+ SR+I C  C   DYHF++P 
Sbjct:   53 CCMPSGC-LCSEESIDPSDAGDAVRVVCNNEACSEGTWMHKVCFDDWEDGVLA-YLKSCGRARSWS-EKQRLQNLWTKKGYDLAFKACDCRCGRGHLRKDLDYISPPKNDNARKHKKKTKKNDRPMPVVTSGKSGSHNVNHNVNQNQVEHGNQNVAGQNGNRNNHGQSIVGNTVNAY---TIRNRTTSSSDDVKLDNANRNVTGILNP----PNKNSIL---NGKTSENNNTGSANSI----SRPINTTAIVRPRTDSLGSTGSSSVISTGSNSPTPSPPRNGNVLIRAPKPKFDTCSTDSTQTSFSNIFRRRHDLAAFNMLPRHKQNPYHIKMEDDGPPGNDETRSFVLNHLSTYKVSSLNCVLCMCTLPVFDRYPMIDGTFFLSPQAYGDGVV----------------------------QVISDGRLQFINAVCVNCLEGASNVHCTACKRKWDGSTLLLGSMYSYDIFAAMPCCQKRLTCKHCRRAVVDIN-----------------NGLAFYSEYSRMIACPYCKAHDYHFIRPM 532          
BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Match: A0A0L8FTK1 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22008945mg PE=4 SV=1)

HSP 1 Score: 187.193 bits (474), Expect = 3.755e-48
Identity = 142/480 (29.58%), Postives = 220/480 (45.83%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSPQMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMH-EIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  RVVC+N NC    W+H  C   WEQ + A  ++S  + R+   ++QR    W +   +L  K+  C C++G LRK  +   P  N+        +  +++   V  S   +N    S   N  G+R                       L  N +    S     LS +  +P         + +Q             L+K+KP+N       S    N+IC     S       ++G+IF++RND + F+ L   KQN Y+I+MED+   GNDDT++F+LS LS   + ++ C++C  +L V+D  PLIDGT FLSP  +  +     +  +   G +  +N       V    +P     ++LN VCI+C+  +  I C  C + W G+ LL+G++Y+YDIFAA+PCC  RL C  C R  +D+                    L  +S+ S +IEC  C  +DYHF++P   I
Sbjct:   83 DAVRVVCNNENCTVGQWMHKLCFETWEQGVLA-YLRSCGRARSWS-EKQRLQNLWTKKGYDLAFKACDCRCSRGHLRKDLNYIPPPQNDNAKKNRKHKKKNDKPIAVMTSKSGMNPNHNS---NTHGSR-----------------------LRTNSISTGSSPPNNYLSSSPTTPAGSPSQTNNVNNQ-------------LKKNKPEN-----GDSVVAGNTICGSGGYSTGN---EVSGSIFKRRNDLSAFKNLRRYKQNPYYIKMEDECSHGNDDTRIFVLSTLSIHKMGSLPCVLCRCELPVFDRYPLIDGTLFLSPEPYQKNTVKETTHVNSIGGDSTDTNYQHHQIQVVFDGKP-----QYLNAVCIHCLEGKTDIRCSACKKRWDGSTLLLGTMYSYDIFAAMPCCPKRLTCRHCCRAVVDVTTG-----------------LPYYSEYSHIIECPYCKIKDYHFIRPLHEI 491          
BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Match: V3ZCW3 (Headcase domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_106234 PE=4 SV=1)

HSP 1 Score: 184.496 bits (467), Expect = 9.317e-48
Identity = 151/508 (29.72%), Postives = 226/508 (44.49%), Query Frame = 1
Query:  499 KCCYD---EEGKNRIHS----DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRK-FDH-NSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLD------NSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSPQMKDFLPTTIKSQSQQN-PKPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMH-EIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFA 1971
            KCC+     E +N I      D  +V+C+N NC    W+H +C   WE+ + +  ++S  + R+   ++QR    W +   +L  K+  C C +G LRK  D+    P     +A     + N     +V  +H  VNNQ+  S  N+  N     D      ++ I S I  T   R RT S              +S T  SP      P +  S+S  N   P++N  +  K +  +   H                   +  +  + GNIFR+R D + F  LP  KQN Y+I+MEDD   GNDDT+ F+LS+LS   ++++ C++C   L V+D  PLIDGT FLSP  +  +                              Q   +   +FLN  C+ C+     I C  C + W G+ LL+G++YTYDIFAA+PCC  RL C  C R  +DL++                  L+ +SQ S++  C  C   DYHF++P  
Sbjct:    3 KCCFPNGCRESENLIDPEEALDAVKVICNNENCTIGNWMHRSCFDEWEESVLS-YLRSCGRARSWS-EKQRLQNLWTKKGYDLAFKACDCKCGRGHLRKDLDYIQPTPSVEITKAKKKHKKKNDKPLPVVSTNHKTVNNQNHPS--NHSPNTAVPSDTNGNTTSTPIKSLIQSTAHLRLRTDS--------------VSSTGSSP------PNSASSESPPNSASPLSNANLFLKGRRLDGMVH-------------------DHSHIGMPGNIFRRRQDLSAFSMLPKFKQNPYYIKMEDDGPHGNDDTRSFVLSNLSSRKMSSLRCVLCKDVLPVFDRYPLIDGTLFLSPQAYDEAVV----------------------------QVIYEGRIQFLNACCVRCLDGHSDIRCTSCKKLWDGSALLLGTMYTYDIFAAMPCCQKRLTCKYCRRAVVDLHIG-----------------LNFYSQYSQMTICPYCKANDYHFIRPMT 422          
BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Match: A0A3M7QA06 (Headcase isoform X1 OS=Brachionus plicatilis OX=10195 GN=BpHYR1_003249 PE=4 SV=1)

HSP 1 Score: 150.984 bits (380), Expect = 2.506e-35
Identity = 94/247 (38.06%), Postives = 135/247 (54.66%), Query Frame = 1
Query: 1261 AGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCM-----HEIVICCQFCHRPWT--GA-QLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
             GNIF++R D++  ++LP +KQN+  I++ED+   GND+T+ F+LSHLS L +  ++C+ C+  LV+YD  PL+DGT F+SP  +  + SIP   S+                            +++LN VC++C+     HEI   C++C + W   GA  L IG+LY YDIFAA PCCV RL C  CS   +DL     D+  N+S           FS  S   EC  C TR YHF+KP  ++
Sbjct:  263 TGNIFQRREDWSILKKLPVAKQNSIHIRLEDEGPFGNDETRCFVLSHLSSLCIREMSCVFCSCSLVIYDRFPLVDGTMFVSPSMYDKNKSIPAIVSNK---------------------------QQYLNSVCLDCIIGTRRHEIK--CKYCGKLWQSLGAFSLQIGNLYKYDIFAAFPCCVQRLTCFQCSATVMDL-----DAAGNES-----------FSCFSEEKECPQCRTRAYHFIKPLKDL 464          
BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Match: A0A443SNZ1 (Headcase-like protein OS=Leptotrombidium deliense OX=299467 GN=B4U80_01924 PE=4 SV=1)

HSP 1 Score: 147.902 bits (372), Expect = 1.464e-34
Identity = 92/279 (32.97%), Postives = 139/279 (49.82%), Query Frame = 1
Query: 1162 PQNRQRHHSASYHGSNSICKEELVSLNQPNY---NLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQAL-----EKFLNVVCINCMH--EIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF 1968
            P +     S  +  SN    ++ V  +QP     N    IF +R+D+++F  LP  K N+Y I+MEDD   GND+T+  +LS LS   +N  +C++C   ++++D  PLIDG+FF+SP                                   H + S A+     EK+LN VC+ C+    + I C+ C+  W+GA L++GS+Y+YDIFAAVPCC +RL CN+C+ + I                    + L  FS  S  + C++C   D+HFVKP 
Sbjct:  207 PMSGSESQSPGFTESNFASWQKFVFGSQPRRERSNSGSCIFSRRHDYSSFNNLPRHKINSYHIKMEDDVNHGNDETRCLILSILSANRVNRTSCILCHGTMIIFDRYPLIDGSFFISPRR---------------------------------HSKSSVAIDVDGKEKYLNAVCMGCLEGTTVSIRCKNCNTKWSGAHLILGSVYSYDIFAAVPCCADRLRCNNCTHLVIPPQ-----------------TRLEYFSDYSHSMSCSHCGILDHHFVKPL 435          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Cavefish
Match: heca (hdc homolog, cell cycle regulator [Source:ZFIN;Acc:ZDB-GENE-041001-173])

HSP 1 Score: 128.642 bits (322), Expect = 1.221e-30
Identity = 124/509 (24.36%), Postives = 197/509 (38.70%), Query Frame = 1
Query:  541 DLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTP-------WLEVIQNLIPKSYLCPCNQGTLRKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVL------SPTEFSPQMKDFLPTTIKSQSQQNPKPVAN---GMILQKSKPQNRQRHHSASYHG-----------SNSICKEELVSLNQPNYNLAGNIFRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            D  RV+C++ +C    W+H  C   WE  I A            C+ R RS+         W +   +L  +   C C QG L+K          + +        +  ++K++P      + ++G+S    G + ++S +     S      R  ++ LS  Q +   ++  R        SP +  P    F         QQ   P ++   G  L+ +      R H  +  G           +  +C   L + + P        F +R D +     +P  K N Y ++MEDD+  G  +D + F+LS LS    N V C +C   L +++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  ID+ V                  +  FS+ S + +C +C   DYHFVKPF++ 
Sbjct:  233 DYQRVLCNSEHCPYGNWMHLQCFYEWESSILAQF---------NCIGRARSWNEKQCRQNMWTKKGYDLAFRFCSCRCGQGHLKK----------DTDWYQVKRMQDDRKKKVLPEKSGAKSREAGAS---GGCSGESSEEPKKGKSSSKLAHRGSNQELSRRQSMERQNSQERCHMGAACDSPGQSPPSGFSFF------SPQQAGGPRSSRHLGEFLKSAVHMEGGRKHILTTRGGAHPDHGAAVAAAGLCLPRLAAGDNPVQ------FLRRLDLSELLTHIPRHKLNTYHVRMEDDAQAGQGEDLRKFILSALSASHRNVVHCALCHRTLPIFEQFPLVDGTLFLSPSRHEEIEYDVPCHL--------------------------QGRLMHLYAICVDCLEGVHKIVCIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVIDVRVG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSSF 664          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Nematostella
Match: EDO38854 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBU4])

HSP 1 Score: 100.523 bits (249), Expect = 1.179e-24
Identity = 64/214 (29.91%), Postives = 103/214 (48.13%), Query Frame = 1
Query: 1345 MEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI--VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANIS 1980
            MED+   G++D + F+LS LS      V C++C+ QL V+D  PLIDGTFFL+P   +  C                             +   +   ++L+ VC++C+  +   I C+ C + W G+   +G+LYTYDIFAA PCC  R+ C SC +  ++L                  + +  FS+ S+ ++C +C    YH +KP  + +
Sbjct:    1 MEDE---GSEDGRYFVLSSLSSQMTTNVNCVLCSRQLQVFDKYPLIDGTFFLTPRKLAAHCI----------------------------EVSQKGKARYLSAVCMHCLEGVPNAIKCKLCSKTWDGSTHQLGTLYTYDIFAASPCCQQRVACQSCGKPVLELKPE---------------NDVQFFSEYSQRLKCPHCGVSAYHCIKPLTSFA 168          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Medaka
Match: heca (hdc homolog, cell cycle regulator [Source:NCBI gene;Acc:101160705])

HSP 1 Score: 107.842 bits (268), Expect = 3.345e-24
Identity = 72/237 (30.38%), Postives = 105/237 (44.30%), Query Frame = 1
Query: 1273 FRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFAN 1974
            F +R D +     +P  K N Y ++MEDD+  G  ++ + F+LS LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  +D+ V                  +  FS+ S + +C +C   DYHFVKPF++
Sbjct:  337 FLRRLDLSELLAHIPRHKLNTYHVRMEDDAQAGQGEELRRFILSALSASERNVVNCALCHRTLPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAICVDCLEGVHKIVCIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVVDVRVG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSS 530          
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Medaka
Match: heca (hdc homolog, cell cycle regulator [Source:NCBI gene;Acc:101160705])

HSP 1 Score: 107.457 bits (267), Expect = 4.084e-24
Identity = 72/237 (30.38%), Postives = 105/237 (44.30%), Query Frame = 1
Query: 1273 FRQRNDFNNF-QRLPFSKQNAYFIQMEDDSCTG-NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEI-VICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFAN 1974
            F +R D +     +P  K N Y ++MEDD+  G  ++ + F+LS LS    N V C +C   L V++  PL+DGT FLSP  H                                     Q     L  +C++C+  +  I C  C   W G+   +G++YTYDI AA PCC  RL C  C +  +D+ V                  +  FS+ S + +C +C   DYHFVKPF++
Sbjct:  326 FLRRLDLSELLAHIPRHKLNTYHVRMEDDAQAGQGEELRRFILSALSASERNVVNCALCHRTLPVFEQFPLVDGTLFLSPSRHDEIEYDVPCHL--------------------------QGRLMHLYAICVDCLEGVHKIVCIKCKSRWDGSWHQLGTMYTYDILAASPCCQARLNCKHCGKPVVDVRVG-----------------MQYFSEYSNVQQCPHCGNLDYHFVKPFSS 519          
BLAST of DNA methyltransferase 1-associated protein vs. Planmine SMEST
Match: SMESG000023267.1 (SMESG000023267.1)

HSP 1 Score: 1031.94 bits (2667), Expect = 0.000e+0
Identity = 548/553 (99.10%), Postives = 551/553 (99.64%), Query Frame = 1
Query:  319 MPTDLQAXXXXXXXIRKQSSLDESYGFDKSKMETSLSKELNQTHLNGSINSFYCCTPIGLKCCYDEEGKNRIHSDLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSPQMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFXXXXXXXXXXXXXXXXXXXXXGTAAXXXXXXXXXXXXXHQQPSQALEKFLNVVCINCMHEIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVCIDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 1977
            MPTDLQASSSSSSSIRKQSSLDESYGFDKSKMETSLSKELNQTHLNGSINSFYCCTPIGLKCCYDEEGKNRIHSDLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSF NNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSPQMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFLSPLCHSPSCSIPISASSHPPGTAAGSNN+SGGSSVGGHQQPSQALEKFLNVVCINCMHEIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCN+C+RVCIDLNVNSVDSISNKSINLCL SMLSNFSQLSRLIECTNCHTRDYHFVKPFANI
Sbjct:    1 MPTDLQASSSSSSSIRKQSSLDESYGFDKSKMETSLSKELNQTHLNGSINSFYCCTPIGLKCCYDEEGKNRIHSDLCRVVCSNYNCDQSGWIHTACLSLWEQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTLRKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFPNNGGNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSPQMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQNRQRHHSASYHGSNSICKEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTGNDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFLSPLCHSPSCSIPISASSHPPGTAAGSNNNSGGSSVGGHQQPSQALEKFLNVVCINCMHEIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNNCNRVCIDLNVNSVDSISNKSINLCLSSMLSNFSQLSRLIECTNCHTRDYHFVKPFANI 553          
The following BLAST results are available for this feature:
BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
HECA4.618e-2925.65hdc homolog, cell cycle regulator [Source:HGNC Sym... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
cri-13.269e-1625.53Conserved Regulator of Innate immunity [Source:Un... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 4
Match NameE-valueIdentityDescription
hdc2.389e-3333.33gene:FBgn0010113 transcript:FBtr0085621[more]
hdc5.931e-3333.33gene:FBgn0010113 transcript:FBtr0085619[more]
hdc5.931e-3333.33gene:FBgn0010113 transcript:FBtr0330311[more]
hdc1.462e-2732.24gene:FBgn0010113 transcript:FBtr0085620[more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
heca1.127e-2430.67hdc homolog, cell cycle regulator [Source:ZFIN;Acc... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
heca1.152e-3025.80hdc homolog, cell cycle regulator [Source:NCBI gen... [more]
heca1.478e-2025.35hdc homolog, cell cycle regulator [Source:NCBI gen... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Heca1.509e-3026.82hdc homolog, cell cycle regulator [Source:MGI Symb... [more]
Heca1.242e-1328.39hdc homolog, cell cycle regulator [Source:MGI Symb... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|Q9N2M8|HDC_DROME2.395e-3233.33Headcase protein OS=Drosophila melanogaster OX=722... [more]
sp|Q9UBI9|HDC_HUMAN2.218e-2825.65Headcase protein homolog OS=Homo sapiens OX=9606 G... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A210QFT75.039e-5029.52Headcase protein-like OS=Mizuhopecten yessoensis O... [more]
A0A0L8FTK13.755e-4829.58Uncharacterized protein OS=Octopus bimaculoides OX... [more]
V3ZCW39.317e-4829.72Headcase domain-containing protein OS=Lottia gigan... [more]
A0A3M7QA062.506e-3538.06Headcase isoform X1 OS=Brachionus plicatilis OX=10... [more]
A0A443SNZ11.464e-3432.97Headcase-like protein OS=Leptotrombidium deliense ... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
heca1.221e-3024.36hdc homolog, cell cycle regulator [Source:ZFIN;Acc... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO388541.179e-2429.91Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 2
Match NameE-valueIdentityDescription
heca3.345e-2430.38hdc homolog, cell cycle regulator [Source:NCBI gen... [more]
heca4.084e-2430.38hdc homolog, cell cycle regulator [Source:NCBI gen... [more]
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BLAST of DNA methyltransferase 1-associated protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000023267.10.000e+099.10SMESG000023267.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020379 ID=SMED30020379|Name=DNA methyltransferase 1-associated protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2056bp
TGAAAGGAGAATTAACGAATTATATTTTCATAGATAGATTAAAATATTAA
ATTGGAGAAAAATCCAAAATATTATATAAATTTTATACATTTATCAAGGC
CAGTTAGCATAAATCAATATAATTTCTATCTTTTTCTAACCAGTGTATTT
ACTACAATTCTAAAGCTCTACGACACATTTGTGTGGCTGCATGCTCCCTG
CTCTGACTAATCAACACACCGATAAATCAGCCAATCAGATCGCCAGATTT
TGTATTGAATTTCAGCCAAACATGTATGTCTGAATTTCATTTCAAATATA
TCAATCAAAAGTAAGCTTATGCCGACTGATCTACAAGCTAGTTCATCATC
ATCTTCCTCAATTCGCAAACAAAGCTCTTTGGATGAGTCATATGGATTTG
ATAAGTCCAAGATGGAAACTAGTTTATCGAAAGAGTTGAATCAAACTCAT
TTAAATGGATCTATCAATTCTTTTTACTGTTGCACACCGATCGGATTAAA
ATGTTGCTATGATGAAGAAGGTAAAAATCGAATCCATTCCGATCTTTGTC
GAGTTGTATGTTCAAATTATAATTGTGATCAAAGTGGATGGATCCATACT
GCTTGCCTTAGCTTGTGGGAACAAAAGATTAGAGCCGATATCATGAAATC
AAATCCTCAAATACGTGCCGCCTGCCTTGATCGTCAGCGATCCTTCACCC
CGTGGCTTGAAGTAATTCAGAATCTAATCCCCAAAAGCTATCTCTGTCCA
TGCAATCAAGGCACACTGAGAAAATTTGATCACAATTCGGGTCCAGGAAC
TAATAATGCGGAAGCATCATATTTTGCGGGTCAAAATAATTCTAATCGTC
GAAAGTTAGTTCCTAATTCCCATATGCAGGTGAATAATCAGTCGGGGTCA
AGCTTTCTGAATAACGGCGGCAACAGAAAGAACTCCTTGGACAACAGTTC
TATAAATTCCTATATAAACTTCACCAAAAGATTTCGATCACGAACTCTCA
GTGCAAATCAAATGTTGATCAACTATTCGACGGATGGACGGGTGCTGAGT
CCAACGGAGTTCTCGCCACAAATGAAAGACTTCCTACCGACAACAATCAA
ATCTCAGTCACAACAAAATCCAAAACCTGTTGCCAATGGAATGATCCTCC
AGAAATCCAAACCCCAAAACCGACAACGTCATCACTCAGCCAGTTATCAT
GGCTCTAATTCTATTTGTAAAGAAGAGCTGGTCTCTTTAAATCAACCAAA
TTATAATTTGGCTGGAAATATTTTCCGGCAAAGAAACGATTTCAACAATT
TCCAGAGACTTCCGTTTTCCAAACAAAATGCCTATTTTATTCAAATGGAA
GACGACAGCTGTACCGGAAATGATGACACAAAAGTATTTCTACTCAGTCA
TTTAAGCCAACTCGGTTTGAATACGGTTACATGTTTGATTTGCGCGTCCC
AATTGGTTGTTTATGATCATTTGCCTCTTATTGATGGCACATTTTTCTTG
AGTCCTTTATGCCATTCCCCCAGCTGTAGCATTCCGATCTCAGCTTCCAG
CCATCCACCTGGTACTGCTGCAGGTAGTAACAACAGTTCAGGTGGATCAT
CAGTTGGTGGACACCAACAACCGTCTCAGGCGCTAGAGAAATTTCTCAAT
GTCGTCTGTATCAATTGCATGCATGAGATTGTTATTTGCTGTCAGTTTTG
CCATCGGCCATGGACTGGTGCTCAGTTACTGATCGGCAGCCTGTACACGT
ACGATATATTTGCAGCCGTTCCGTGTTGTGTCAACCGACTATTGTGCAAT
AGTTGCAGTCGGGTTTGCATTGATCTGAACGTCAACTCTGTAGATTCGAT
CAGCAACAAATCGATCAATTTGTGCTTACCGTCGATGCTGTCCAATTTCA
GCCAATTGAGCCGGCTGATCGAGTGCACCAATTGTCACACTCGAGATTAC
CATTTTGTCAAGCCGTTCGCAAATATTTCAGGCCGATTGTCTAGGCTCGA
TGCAAATATTATTTATATAATTTAGATTGGCGTTCCTTGTATTTTCTATG
ATATAT
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protein sequence of SMED30020379-orf-1

>SMED30020379-orf-1 ID=SMED30020379-orf-1|Name=SMED30020379-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=569bp
MPTDLQASSSSSSSIRKQSSLDESYGFDKSKMETSLSKELNQTHLNGSIN
SFYCCTPIGLKCCYDEEGKNRIHSDLCRVVCSNYNCDQSGWIHTACLSLW
EQKIRADIMKSNPQIRAACLDRQRSFTPWLEVIQNLIPKSYLCPCNQGTL
RKFDHNSGPGTNNAEASYFAGQNNSNRRKLVPNSHMQVNNQSGSSFLNNG
GNRKNSLDNSSINSYINFTKRFRSRTLSANQMLINYSTDGRVLSPTEFSP
QMKDFLPTTIKSQSQQNPKPVANGMILQKSKPQNRQRHHSASYHGSNSIC
KEELVSLNQPNYNLAGNIFRQRNDFNNFQRLPFSKQNAYFIQMEDDSCTG
NDDTKVFLLSHLSQLGLNTVTCLICASQLVVYDHLPLIDGTFFLSPLCHS
PSCSIPISASSHPPGTAAGSNNSSGGSSVGGHQQPSQALEKFLNVVCINC
MHEIVICCQFCHRPWTGAQLLIGSLYTYDIFAAVPCCVNRLLCNSCSRVC
IDLNVNSVDSISNKSINLCLPSMLSNFSQLSRLIECTNCHTRDYHFVKPF
ANISGRLSRLDANIIYII*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0035267NuA4 histone acetyltransferase complex
GO:0005737cytoplasm
GO:0030424axon
GO:0030425dendrite
GO:0048471perinuclear region of cytoplasm
Vocabulary: biological process
TermDefinition
GO:0006281DNA repair
GO:0006338chromatin remodeling
GO:0032259methylation
GO:0043967histone H4 acetylation
GO:0043968histone H2A acetylation
GO:0045892negative regulation of transcription, DNA-templated
GO:0002165instar larval or pupal development
GO:0007275multicellular organism development
GO:0007430terminal branching, open tracheal system
GO:0007476imaginal disc-derived wing morphogenesis
GO:0016246RNA interference
GO:0022008neurogenesis
GO:0035071salivary gland cell autophagic cell death
GO:0035147branch fusion, open tracheal system
GO:0035155negative regulation of terminal cell fate specification, open tracheal system
GO:0048675axon extension
GO:0050768negative regulation of neurogenesis
GO:1904799regulation of neuron remodeling
Vocabulary: molecular function
TermDefinition
GO:0008168methyltransferase activity
GO:0016740transferase activity
GO:0003674molecular_function
GO:0005515protein binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
PLANA:0002056medial muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR026066Headcase
IPR031947Headcase_mid