SH3 domain-containing kinase-binding protein 1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020355 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 8
Homology
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Match: SH3KBP1 (SH3 domain containing kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:13867]) HSP 1 Score: 124.79 bits (312), Expect = 3.990e-29 Identity = 99/282 (35.11%), Postives = 137/282 (48.58%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKET-------------TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N V PKKV GVGFG+IF IKL+ + + + + E + + +K P T T++KD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A +IK G T K +I K IPP P++L
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE---KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQG--AGTTERKHEI---KKIPPERPEML 335 HSP 2 Score: 56.9954 bits (136), Expect = 1.080e-7 Identity = 26/61 (42.62%), Postives = 40/61 (65.57%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENN 693
+V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E++
Sbjct: 66 CQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESD 123
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Match: SH3KBP1 (SH3 domain containing kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:13867]) HSP 1 Score: 124.02 bits (310), Expect = 7.893e-29 Identity = 99/282 (35.11%), Postives = 137/282 (48.58%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKET-------------TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N V PKKV GVGFG+IF IKL+ + + + + E + + +K P T T++KD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A +IK G T K +I K IPP P++L
Sbjct: 105 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE---KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQG--AGTTERKHEI---KKIPPERPEML 372 HSP 2 Score: 92.0485 bits (227), Expect = 1.092e-18 Identity = 62/208 (29.81%), Postives = 96/208 (46.15%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNK 696
++ ++EFDY A DELTI G+II ++R + GW G + G+ G+FP NF + +K++ +K N P K + V GN E L+T K R + +V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E+++
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN----------------------KAPEKPLHEVPSGNSLLSSETILRTN-----------------------KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESDE 161 HSP 3 Score: 62.003 bits (149), Expect = 2.777e-9 Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNA 717
Y A++ DELT+ +G+IIT N ED GWW G + NG+ G+FPDNFV IK+E K N A
Sbjct: 10 YQAQHDDELTISVGEIIT--NIRKEDGGWWEG-QINGRRGLFPDNFVREIKKEMKKDPLTNKA 69
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Match: CD2AP (CD2 associated protein [Source:HGNC Symbol;Acc:HGNC:14258]) HSP 1 Score: 117.087 bits (292), Expect = 1.128e-26 Identity = 82/225 (36.44%), Postives = 118/225 (52.44%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK----EDRRKSQEDNLII------PQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPE---ILQEKKPK----ETTRT--------KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ F+Y DEL + GDII+ E+GW G L K G+FPSNF K ++ + ++Q+D+ + P N + + V + PKK+ G+GFG+IF G +KL+T ++ +EE KPE ILQ PK E T+T K+ R + +Y N DELT + G+II + +KE + GWWRG + NG+ GVFPDNF I E
Sbjct: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQ----PKKIRGIGFGDIFKEGSVKLRTRTSSSE----TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFPDNFAVQINE 330 HSP 2 Score: 97.0561 bits (240), Expect = 3.023e-20 Identity = 69/229 (30.13%), Postives = 118/229 (51.53%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSR--PNNAAIIKAGPPPPV 750
+DY++E+DYDA DELTI G+II +V+ E+GW+ G L G+ G+FP NF VKE +R+++ + +P ER+ N ++++ G +GG ++P + K + K +V+ Y +N DEL L++GDII + E+ +EGWW G +N + G+FP NFV+ ++ ++ + +++ + AGP P+
Sbjct: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNF---VKEIKRETEFKDDSLPIKRERHGNV---------ASLVQRISTYGLP---AGG-------------------IQPH--PQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDIN--EEVEEGWWSGTLNN-KLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPI 191
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Match: SH3D21 (SH3 domain containing 21 [Source:HGNC Symbol;Acc:HGNC:26236]) HSP 1 Score: 91.2781 bits (225), Expect = 2.014e-18 Identity = 59/199 (29.65%), Postives = 88/199 (44.22%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKV--ISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEP 675
+ F Y ++ADEL + G+I+ ++ EDGW G G+ G FPSNF + +++ PP GN ++ + PK+ ++ + P+ LQ T +V RV+ Y E DEL L GD++ V +K ED+GWW G + G+ GVFPDNFV P
Sbjct: 90 VNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVE-------------------------------LLDSGPP-------SLGN----PDMPSVSPGPQRPPKLSSLAYDSPPDYLQ------TVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEG-ECQGRRGVFPDNFVLP 239 HSP 2 Score: 60.4622 bits (145), Expect = 9.628e-9 Identity = 41/110 (37.27%), Postives = 57/110 (51.82%), Query Frame = 1
Query: 481 PKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQL 810
P + R + +V SY+ E +DEL L+ G+I+ + KE ED GWW G+K NGQ G FP NFVE ++ +GPP P ++ G P RPP+L
Sbjct: 78 PAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMI-KEIED-GWWLGKK-NGQLGAFPSNFVE----------------LLDSGPPSLGNPDMPSVSPG---PQRPPKL 165
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Match: SH3KBP1 (SH3 domain containing kinase binding protein 1 [Source:HGNC Symbol;Acc:HGNC:13867]) HSP 1 Score: 88.9669 bits (219), Expect = 7.932e-18 Identity = 60/208 (28.85%), Postives = 96/208 (46.15%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNK 696
++ ++EFDY A DELTI G+II ++R + GW G + G+ G+FP NF + +K++ +K N P K + V GN E L+T + + + +V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E+++
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN----------------------KAPEKPLHEVPSGNSLLSSETILRTNKRGER-----------------------RRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESDE 161 HSP 2 Score: 87.4261 bits (215), Expect = 2.715e-17 Identity = 70/185 (37.84%), Postives = 97/185 (52.43%), Query Frame = 1
Query: 316 NDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKET-------------TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
N V PKKV GVGFG+IF IKL+ + + + + E + + +K P T T++KD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A +IK G T K +I K IPP P++L
Sbjct: 241 NGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE---KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQG--AGTTERKHEI---KKIPPERPEML 416
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 61.6178 bits (148), Expect = 8.362e-10 Identity = 49/215 (22.79%), Postives = 88/215 (40.93%), Query Frame = 1
Query: 82 LIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGIL-RGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAA 720
+++F Y+ DEL + KGD + V DGW G G G FPSN+ + V+ +Q E RN ++ Q PPPK LQ + + +VV ++S+ A +S+EL+ + G+ + + + + D WW R ++G +G+ P N++E + + ++ + + A
Sbjct: 120 VVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQ------GSIENRNPAAAAVPAPIMMQAPPPK--------------------------------------LQASRS-----SFEVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVVNDSSSSKASHQDFA 285 HSP 2 Score: 59.6918 bits (143), Expect = 3.428e-9 Identity = 63/245 (25.71%), Postives = 102/245 (41.63%), Query Frame = 1
Query: 76 DYLI-EFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK----------EENNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
DY++ ++DY A E ELTI K + + + ++ W G PSN+ V+++ + I A RN ++ P +++ G+ +L + +N V P K P +++TK VV+ +Y DEL L GD + V E +GWW+G NG G FP N+VE ++ E N + A I+ PPP + A++ V
Sbjct: 4 DYVVVKYDYLAQEEQELTIKKNERLKLLDDSKNWWKVMNDSNSVGFVPSNY---VRKESIVDKAKGTIKGLARGRNRSS--------DPEPEERLNGIA----------RLAFSLNNNCA------VTPS--SNKIPMMSSKTKAVVKF--TYEPRLEDELGLTKGDFVYVV--EKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEV 215
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 60.4622 bits (145), Expect = 9.340e-10 Identity = 48/201 (23.88%), Postives = 82/201 (40.80%), Query Frame = 1
Query: 82 LIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGIL-RGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+++F Y+ DEL + KGD + V DGW G G G FPSN+ + V+ +Q E RN ++ Q PPPK LQ + ++ VV ++S+ A +S+EL+ + G+ + + + + D WW R ++G +G+ P N++E +
Sbjct: 8 VVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQ------GSIENRNPAAAAVPAPIMMQAPPPK--------------------------------------LQASR---SSFEIQVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVV 161 HSP 2 Score: 53.1434 bits (126), Expect = 2.479e-7 Identity = 33/106 (31.13%), Postives = 50/106 (47.17%), Query Frame = 1
Query: 490 TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK----------EENNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
+++TK VV+ +Y DEL L GD + V K + GWW+G NG G FP N+VE ++ E N + A I+ PPP + A++ +
Sbjct: 2 SSKTKAVVKF--TYEPRLEDELGLTKGDFVYVVEKSTD--GWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEI 103
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 60.4622 bits (145), Expect = 9.340e-10 Identity = 48/201 (23.88%), Postives = 82/201 (40.80%), Query Frame = 1
Query: 82 LIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGIL-RGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+++F Y+ DEL + KGD + V DGW G G G FPSN+ + V+ +Q E RN ++ Q PPPK LQ + ++ VV ++S+ A +S+EL+ + G+ + + + + D WW R ++G +G+ P N++E +
Sbjct: 8 VVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQ------GSIENRNPAAAAVPAPIMMQAPPPK--------------------------------------LQASR---SSFEIQVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVV 161 HSP 2 Score: 53.1434 bits (126), Expect = 2.479e-7 Identity = 33/106 (31.13%), Postives = 50/106 (47.17%), Query Frame = 1
Query: 490 TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK----------EENNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
+++TK VV+ +Y DEL L GD + V K + GWW+G NG G FP N+VE ++ E N + A I+ PPP + A++ +
Sbjct: 2 SSKTKAVVKF--TYEPRLEDELGLTKGDFVYVVEKSTD--GWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEI 103
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Match: nck-1 (NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family [Source:UniProtKB/TrEMBL;Acc:Q95PX0]) HSP 1 Score: 60.4622 bits (145), Expect = 9.340e-10 Identity = 48/201 (23.88%), Postives = 82/201 (40.80%), Query Frame = 1
Query: 82 LIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGIL-RGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+++F Y+ DEL + KGD + V DGW G G G FPSN+ + V+ +Q E RN ++ Q PPPK LQ + ++ VV ++S+ A +S+EL+ + G+ + + + + D WW R ++G +G+ P N++E +
Sbjct: 8 VVKFTYEPRLEDELGLTKGDFVYVVEKSTDGWWKGEAPNGGVGWFPSNYVEEVEASTNGNQ------GSIENRNPAAAAVPAPIMMQAPPPK--------------------------------------LQASR---SSFEIQVVVALYSFDASSSEELSFKKGERLEIVDHPEHDPDWWMARNASGTTGLVPRNYIEVV 161 HSP 2 Score: 53.1434 bits (126), Expect = 2.479e-7 Identity = 33/106 (31.13%), Postives = 50/106 (47.17%), Query Frame = 1
Query: 490 TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK----------EENNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
+++TK VV+ +Y DEL L GD + V K + GWW+G NG G FP N+VE ++ E N + A I+ PPP + A++ +
Sbjct: 2 SSKTKAVVKF--TYEPRLEDELGLTKGDFVYVVEKSTD--GWWKGEAPNGGVGWFPSNYVEEVEASTNGNQGSIENRNPAAAAVPAPIMMQAPPPKLQASRSSFEI 103
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Match: cdap-2 (CD2AP homolog [Source:UniProtKB/TrEMBL;Acc:Q6A573]) HSP 1 Score: 62.003 bits (149), Expect = 9.720e-10 Identity = 31/66 (46.97%), Postives = 45/66 (68.18%), Query Frame = 1
Query: 487 ETTRTKDVVRVIHSYTAENSDELTL-EIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK 681
ETT+TK++ RV Y ++ DEL L EI +I +TNK D GW+ G + +G+ G+FPDNFVE ++
Sbjct: 187 ETTKTKEMARVKFVYNPQHDDELALKEIDMLINITNKNCGDAGWFEG-ELHGKKGLFPDNFVELVQ 251
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Match: cindr (gene:FBgn0027598 transcript:FBtr0085704) HSP 1 Score: 87.8113 bits (216), Expect = 1.682e-17 Identity = 63/205 (30.73%), Postives = 91/205 (44.39%), Query Frame = 1
Query: 70 DMDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILR--GKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++ ++E++Y A E DEL + KG II+ ++ GW G L+ G G+FP NF + V+E V+ G G SG I++ T + L++K R K VI+SYT N DELTL +GD+I + +EGWWRGR + + GVFP NFV+ I
Sbjct: 4 NICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVR-------------------------------VLE-----SGVSSNGNGTTGSGDHIEVGTAVQ---------------LRDKSATSNRRCK----VIYSYTQVNDDELTLAVGDVIEFLG--EVEEGWWRGRLRS-KVGVFPSNFVQHI 150 HSP 2 Score: 59.3066 bits (142), Expect = 1.137e-8 Identity = 27/59 (45.76%), Postives = 39/59 (66.10%), Query Frame = 1
Query: 502 KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++ RV Y +N DEL L++ DII V + E D+GWW+G + G+ GVFPDNFV+ +
Sbjct: 255 REFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKG-EIRGKVGVFPDNFVKML 312
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Match: cindr (gene:FBgn0027598 transcript:FBtr0310424) HSP 1 Score: 87.4261 bits (215), Expect = 2.271e-17 Identity = 63/205 (30.73%), Postives = 91/205 (44.39%), Query Frame = 1
Query: 70 DMDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILR--GKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++ ++E++Y A E DEL + KG II+ ++ GW G L+ G G+FP NF + V+E V+ G G SG I++ T + L++K R K VI+SYT N DELTL +GD+I + +EGWWRGR + + GVFP NFV+ I
Sbjct: 4 NICAIVEYEYAAKEPDELDLQKGAIIHRIKQMPGGWWQGTLKASGVTGMFPDNFVR-------------------------------VLES-----GVSSNGNGTTGSGDHIEVGTAVQ---------------LRDKSATSNRRCK----VIYSYTQVNDDELTLAVGDVIEFLG--EVEEGWWRGRLRS-KVGVFPSNFVQHI 150 HSP 2 Score: 59.3066 bits (142), Expect = 1.213e-8 Identity = 27/59 (45.76%), Postives = 39/59 (66.10%), Query Frame = 1
Query: 502 KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++ RV Y +N DEL L++ DII V + E D+GWW+G + G+ GVFPDNFV+ +
Sbjct: 255 REFCRVEFPYAPQNDDELELKVDDIIAVISTELPDKGWWKG-EIRGKVGVFPDNFVKML 312
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Match: drk (gene:FBgn0004638 transcript:FBtr0087695) HSP 1 Score: 60.4622 bits (145), Expect = 5.477e-10 Identity = 55/221 (24.89%), Postives = 96/221 (43.44%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDG-WMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVI---EQTPPPKKVT-----GVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDV-----------VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEP 675
M+ + + D+ A DEL+ K I+ + +D W L GKEG+ PSN+ + D + + AE+ +N E +I E +P ++ GV + + K V+ E+++ + +R++DV V+ ++ + + S EL GD+ITVT++ DE+ WW G N + G+FP +V P
Sbjct: 1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGR---ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLW-------VVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDEN--WWNGEIGN-RKGIFPATYVTP 208
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Match: drk (gene:FBgn0004638 transcript:FBtr0087694) HSP 1 Score: 60.4622 bits (145), Expect = 5.477e-10 Identity = 55/221 (24.89%), Postives = 96/221 (43.44%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDG-WMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVI---EQTPPPKKVT-----GVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDV-----------VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEP 675
M+ + + D+ A DEL+ K I+ + +D W L GKEG+ PSN+ + D + + AE+ +N E +I E +P ++ GV + + K V+ E+++ + +R++DV V+ ++ + + S EL GD+ITVT++ DE+ WW G N + G+FP +V P
Sbjct: 1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGR---ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLW-------VVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDEN--WWNGEIGN-RKGIFPATYVTP 208
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Match: drk (gene:FBgn0004638 transcript:FBtr0087698) HSP 1 Score: 60.4622 bits (145), Expect = 5.477e-10 Identity = 55/221 (24.89%), Postives = 96/221 (43.44%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDG-WMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVI---EQTPPPKKVT-----GVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDV-----------VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEP 675
M+ + + D+ A DEL+ K I+ + +D W L GKEG+ PSN+ + D + + AE+ +N E +I E +P ++ GV + + K V+ E+++ + +R++DV V+ ++ + + S EL GD+ITVT++ DE+ WW G N + G+FP +V P
Sbjct: 1 MEAIAKHDFSATADDELSFRKTQILKILNMEDDSNWYRAELDGKEGLIPSNYIEMKNHDWYYGR---ITRADAEKLLSNKHEGAFLIRISESSPGDFSLSVKCPDGVQHFKVLRDAQSKFFLW-------VVKFNSLNELVEYHRTASVSRSQDVKLRDMIPEEMLVQALYDFVPQESGELDFRRGDVITVTDRSDEN--WWNGEIGN-RKGIFPATYVTP 208
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Match: cd2ap (CD2-associated protein [Source:ZFIN;Acc:ZDB-GENE-030131-8078]) HSP 1 Score: 107.842 bits (268), Expect = 7.074e-24 Identity = 74/224 (33.04%), Postives = 116/224 (51.79%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTK------ENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNK---DNKPKV------ISEEVKPEILQ-------EKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEEN 690
+ F+Y DEL + G+II E+GW G + GK G+FPSNF K + D + E++ + + + R+ + N V+ + PKK+ G+GFG+IF G +KL+T+ K +N K + KP L EK+ + + K+ + Y A N DEL L+ G++I + +K+ + GWWRG + NG+ GVFPDNFV + E +
Sbjct: 130 VLFEYVPQNEDELELKVGEIIEITEEVEEGWWSGSMNGKSGLFPSNFVKEI--DSTEDAENSDVTEEQDTRDGTSSPTSPHPGNGVMAQ----PKKIKGIGFGDIFREGSVKLRTSLKGPSENMEKTEKPIPPLPSATKPTPLSTPEHPKGEKEAESKAKVKEYCKATFHYEATNQDELDLKEGEVILILSKDTGEPGWWRG-EVNGKQGVFPDNFVSLLPESD 346 HSP 2 Score: 77.7962 bits (190), Expect = 1.946e-14 Identity = 63/197 (31.98%), Postives = 97/197 (49.24%), Query Frame = 1
Query: 115 DELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTG--------VGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
DELT+ GDII +VR E+GWM G L GK G+FP NF K V++D P+++E + KE V E++ ++ +G + I +GG I L+ + + + + K +V+ Y +N DEL L++G+ + E+ +EGWW G NG+SG+FP NFV+ I
Sbjct: 16 DELTLRLGDIIKNVRRIEEEGWMEGDLNGKRGLFPDNFVKEVRKDE----------PKSKEESKEPKEAKEVKEESTIQRRASGNVASLVQRISTYGIPAGG-IGLQPHS------------------QPRASKKKLKKRQCKVLFEYVPQNEDELELKVGE--IIEITEEVEEGWWSG-SMNGKSGLFPSNFVKEI 180
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Match: CR936282.1 (SH3-domain kinase binding protein 1 [Source:NCBI gene;Acc:793623]) HSP 1 Score: 106.686 bits (265), Expect = 1.507e-23 Identity = 80/256 (31.25%), Postives = 113/256 (44.14%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKEND----------------VVIEQTPPPKKVTGVG---------------------------------------FGNIFSGGEIKLK-----TTNKDNKPKVISEEVKPEILQEKKPKE---TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
F Y DEL + GD+I+ + E+GW G+LRGK G+FPSNF K V + ED + PQ + R+ T N + + PP K G FG+IF IKL+ N+ KP+++ ++ P I QE E + K+ +VI Y A+N DEL+++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV
Sbjct: 79 FSYTPQNEDELELKIGDVIDVLGEVEEGWWEGVLRGKTGMFPSNFTKEVLAE----VED--LTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKCVCAGIKDSTGSESDGGDSSSLRSDTGSVSSSSEIQPKKVRGFGFGDIFKDQPIKLRPRSVDMDNEAEKPQMV-KKATPAIGQETMKAEHENKAKAKEFCKVIFPYEAQNEDELSIKEGDIVTIINKDCADAGWWLG-ELNGKKGVFPDNFV 326 HSP 2 Score: 54.6842 bits (130), Expect = 3.385e-7 Identity = 33/109 (30.28%), Postives = 50/109 (45.87%), Query Frame = 1
Query: 502 KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEE-----------------NNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
K + SYT +N DEL L+IGD+I V + +EGWW G G++G+FP NF + + E N+ + N+ A+ KA P + P +
Sbjct: 72 KRRCKAAFSYTPQNEDELELKIGDVIDVLG--EVEEGWWEG-VLRGKTGMFPSNFTKEVLAEVEDLTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKC 177
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Match: sh3kbp1 (SH3-domain kinase binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-186]) HSP 1 Score: 105.916 bits (263), Expect = 3.006e-23 Identity = 80/256 (31.25%), Postives = 113/256 (44.14%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKEND----------------VVIEQTPPPKKVTGVG---------------------------------------FGNIFSGGEIKLK-----TTNKDNKPKVISEEVKPEILQEKKPKE---TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
F Y DEL + GD+I+ + E+GW G+LRGK G+FPSNF K V + ED + PQ + R+ T N + + PP K G FG+IF IKL+ N+ KP+++ ++ P I QE E + K+ +VI Y A+N DEL+++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV
Sbjct: 107 FSYTPQNEDELELKIGDVIDVLGEVEEGWWEGVLRGKTGMFPSNFTKEVLAE----VED--LTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKCVCAGIKDSTGSESDGGDSSSLRSDTGSVSSSSEIQPKKVRGFGFGDIFKDQPIKLRPRSVDMDNEAEKPQMV-KKATPAIGQETMKAEHENKAKAKEFCKVIFPYEAQNEDELSIKEGDIVTIINKDCADAGWWLG-ELNGKKGVFPDNFV 354 HSP 2 Score: 61.6178 bits (148), Expect = 2.196e-9 Identity = 25/51 (49.02%), Postives = 35/51 (68.63%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNF 225
++ ++EFDY + DELTI GDII+++R E GW G L G+ G+FP NF
Sbjct: 1 VEAIVEFDYQSQHDDELTIAVGDIISNIRKDEGGWWEGELDGRRGLFPDNF 51 HSP 3 Score: 54.6842 bits (130), Expect = 3.694e-7 Identity = 32/106 (30.19%), Postives = 49/106 (46.23%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEE-----------------NNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
+ SYT +N DEL L+IGD+I V + +EGWW G G++G+FP NF + + E N+ + N+ A+ KA P + P +
Sbjct: 103 CKAAFSYTPQNEDELELKIGDVIDVLG--EVEEGWWEG-VLRGKTGMFPSNFTKEVLAEVEDLTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKC 205 HSP 4 Score: 51.9878 bits (123), Expect = 2.223e-6 Identity = 24/54 (44.44%), Postives = 36/54 (66.67%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
V Y +++ DELT+ +GDII+ N ++ GWW G + +G+ G+FPDNFV I
Sbjct: 5 VEFDYQSQHDDELTIAVGDIIS--NIRKDEGGWWEG-ELDGRRGLFPDNFVREI 55
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Match: sh3kbp1 (SH3-domain kinase binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-186]) HSP 1 Score: 105.916 bits (263), Expect = 3.014e-23 Identity = 80/256 (31.25%), Postives = 113/256 (44.14%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVV----------------IEQTPPPKKVTGVG---------------------------------------FGNIFSGGEIKLK-----TTNKDNKPKVISEEVKPEILQEKKPKE---TTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
F Y DEL + GD+I+ + E+GW G+LRGK G+FPSNF K V + ED + PQ + R+ T N + + PP K G FG+IF IKL+ N+ KP+++ ++ P I QE E + K+ +VI Y A+N DEL+++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV
Sbjct: 108 FSYTPQNEDELELKIGDVIDVLGEVEEGWWEGVLRGKTGMFPSNFTKEVLAE----VED--LTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKCVCAGIKDSTGSESDGGDSSSLRSDTGSVSSSSEIQPKKVRGFGFGDIFKDQPIKLRPRSVDMDNEAEKPQMV-KKATPAIGQETMKAEHENKAKAKEFCKVIFPYEAQNEDELSIKEGDIVTIINKDCADAGWWLG-ELNGKKGVFPDNFV 355 HSP 2 Score: 61.6178 bits (148), Expect = 2.315e-9 Identity = 25/51 (49.02%), Postives = 35/51 (68.63%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNF 225
++ ++EFDY + DELTI GDII+++R E GW G L G+ G+FP NF
Sbjct: 2 VEAIVEFDYQSQHDDELTIAVGDIISNIRKDEGGWWEGELDGRRGLFPDNF 52 HSP 3 Score: 54.6842 bits (130), Expect = 3.729e-7 Identity = 32/106 (30.19%), Postives = 49/106 (46.23%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEE-----------------NNKPSRPNNAAIIKAGPPPPVTAAKPKINV 777
+ SYT +N DEL L+IGD+I V + +EGWW G G++G+FP NF + + E N+ + N+ A+ KA P + P +
Sbjct: 104 CKAAFSYTPQNEDELELKIGDVIDVLG--EVEEGWWEG-VLRGKTGMFPSNFTKEVLAEVEDLTPQDDTRSTRTTLNSGQTYSNSPAVYKAACKSPCKCSDPPVKC 206 HSP 4 Score: 51.9878 bits (123), Expect = 2.244e-6 Identity = 24/54 (44.44%), Postives = 36/54 (66.67%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
V Y +++ DELT+ +GDII+ N ++ GWW G + +G+ G+FPDNFV I
Sbjct: 6 VEFDYQSQHDDELTIAVGDIIS--NIRKDEGGWWEG-ELDGRRGLFPDNFVREI 56
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Match: sh3d21 (SH3 domain containing 21 [Source:ZFIN;Acc:ZDB-GENE-051120-57]) HSP 1 Score: 102.064 bits (253), Expect = 1.526e-22 Identity = 78/249 (31.33%), Postives = 120/249 (48.19%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSV-RPHEDGWMYGILRGKEGVFPSNFGK--PVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFG----------------------NIFSGGEIK-LKTTNKDN---KPKVISEEVKPEILQEKKP---KETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAI 723
M+ L+ ++A DELT+H GDI+ +V + E+GW+ G LRGK G+FP NF K PV ++E I + ++ T++ +VV P + + G F +K + +KD+ +PK+ E +++P K+T+ K+ +V+ Y A DEL L+ GD+ITV NK ED+GWW G + NG+ G FPDNFV I E + A +
Sbjct: 1 MEVLVLLGFEATMPDELTVHVGDIVKNVSKAKEEGWLEGDLRGKRGMFPGNFVKEVPVYLIGDSNREPR-SIRKTKKTTVQTRKCEVVFPYVPTHEDELQLLVGETIEILREIEDGWWMGKKNNQIGAFPSNFVKEIFVPSKDDAKARPKLSGSVFGKEGKLQQRPSLRKKTSNVKECCQVMFDYAAVAEDELNLKKGDVITVINKSTEDDGWWEG-EVNGRRGFFPDNFVMLIPAETLQTGNAGQAPV 247
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Match: lrrc10 (leucine rich repeat containing 10 [Source:Xenbase;Acc:XB-GENE-5959561]) HSP 1 Score: 114.39 bits (285), Expect = 1.019e-25 Identity = 97/290 (33.45%), Postives = 140/290 (48.28%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK-EDRRKSQED------NLIIPQAEERN---NNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPK-------ETTRT--------KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI----KEENNKPSRPNNAAIIKAGPPP--------PVTAAKPKINVGKSIPPRPPQLLEKQAS--KPA 837
+ ++Y DEL + G++++ + E+GW G GK G+FPSNF K + D +SQE ++ P A + + D T PKKV GVGFG+IF G +KLKT +P+V E KP +Q K + +RT K++ + + +Y + N DEL+ + GDII +T+KE D GWW+G + NG+ GVFPDNFV I KE + + +P K P P+ KP +PP+ P L K S KPA
Sbjct: 104 VLYEYIPQNEDELELKVGEVLDIIEEVEEGWWSGSNSGKSGLFPSNFVKEIDLSDDGESQESTEDSEPSVTTPIATPASPVLSPANGPDASPLATAQPKKVMGVGFGDIFKEGSVKLKTRLPAPEPEVKKPE-KPLPVQPSGTKVLRSTSSDASRTETDSKPKAKEICKALFNYESVNEDELSFKEGDIIHLTSKETGDPGWWKG-ELNGKEGVFPDNFVAIIQDSEKEVSLRAPKPELRIAEKKSTPTKTEEKDEKPLVDLKPPKPAAPQVPPKKPNLTSKSNSILKPA 391 HSP 2 Score: 66.2402 bits (160), Expect = 1.248e-10 Identity = 29/54 (53.70%), Postives = 38/54 (70.37%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSV-RPHEDGWMYGILRGKEGVFPSNFGK 231
M+Y++E+DYDA DELTI GD+I +V + EDGW+ G + GK G FP NF K
Sbjct: 9 MEYIVEYDYDAVNEDELTIRVGDVIKNVNKLEEDGWLEGEVNGKRGAFPDNFVK 62 HSP 3 Score: 54.299 bits (129), Expect = 6.121e-7 Identity = 27/51 (52.94%), Postives = 34/51 (66.67%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
V + Y A N DELT+ +GD+I NK +ED GW G + NG+ G FPDNFV
Sbjct: 13 VEYDYDAVNEDELTIRVGDVIKNVNKLEED-GWLEG-EVNGKRGAFPDNFV 61
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Match: tmprss9 (transmembrane serine protease 9 [Source:Xenbase;Acc:XB-GENE-993973]) HSP 1 Score: 113.62 bits (283), Expect = 1.512e-25 Identity = 86/278 (30.94%), Postives = 135/278 (48.56%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKP-VKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQT-------PPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVI------SEEVKPEIL-QEKKPKET---TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPANTVKDDGIS 864
+ F Y DEL + G+II + E+GW G+L GK G+FPSNF + V E + E + + + + D +E T K++ G GFG+IF IKL+ + + + +++ +++ P + QE ET T+ K+ +V+ Y A N DELT+ GDI+TV +KE D GWW G + NG+ GVFPDNFV+ + + K N P PV+ + + IPP P L ++ + + +D +S
Sbjct: 141 VAFSYLPQNEDELELKVGEIIEVLGEVEEGWWEGVLNGKTGMFPSNFIREIVTETEIGNFEQQIKTAFKDTTGSESDGGDSKLEGTNGTSGGETQSKRIRGFGFGDIFKDKPIKLRPRSIEMESEIVPIEKAMGKKMPPTVTSQEPMKIETESKTKRKEYCKVLFPYEAMNEDELTIRDGDIVTVLSKECVDAGWWEG-ELNGKKGVFPDNFVKLLPSDFEKECPVGNFMC-----PCPVSGTSERKQDIRKIPPERPDTLPQRPDEKERSERDHKVS 412 HSP 2 Score: 99.3673 bits (246), Expect = 5.761e-21 Identity = 63/205 (30.73%), Postives = 94/205 (45.85%), Query Frame = 1
Query: 76 DYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEEN 690
D ++EFDY A DELTI GDII ++ + GW G L+G+ G+FP NF + +K+D +K Q N+K PP + G+ GN E +++ + + +V SY +N DEL L++G+II V + +EGWW G NG++G+FP NF+ I E
Sbjct: 39 DAIVEFDYKAQHEDELTITAGDIITKIKKEDGGWWEGELKGRRGLFPDNFVRELKKDTKKEQ--------------NSK---------PPDRPTQGISNGNALLSSEAVIRSAG----------------------RGERTRRRRCQVAFSYLPQNEDELELKVGEIIEVLG--EVEEGWWEG-VLNGKTGMFPSNFIREIVTET 195 HSP 3 Score: 57.7658 bits (138), Expect = 5.986e-8 Identity = 33/69 (47.83%), Postives = 42/69 (60.87%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNK-PSRPNNA 717
Y A++ DELT+ GDIIT KED GWW G + G+ G+FPDNFV + KE+N+K P RP
Sbjct: 46 YKAQHEDELTITAGDIITKIKKEDG--GWWEG-ELKGRRGLFPDNFVRELKKDTKKEQNSKPPDRPTQG 111
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Match: lrrc10 (leucine rich repeat containing 10 [Source:Xenbase;Acc:XB-GENE-5959561]) HSP 1 Score: 110.538 bits (275), Expect = 1.736e-25 Identity = 80/225 (35.56%), Postives = 119/225 (52.89%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK-EDRRKSQED------NLIIPQAEERN---NNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPK-------ETTRT--------KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ ++Y DEL + G++++ + E+GW G GK G+FPSNF K + D +SQE ++ P A + + D T PKKV GVGFG+IF G +KLKT +P+V E KP +Q K + +RT K++ + + +Y + N DEL+ + GDII +T+KE D GWW+G + NG+ GVFPDNFV I++
Sbjct: 112 VLYEYIPQNEDELELKVGEVLDIIEEVEEGWWSGSNSGKSGLFPSNFVKEIDLSDDGESQESTEDSEPSVTTPIATPASPVLSPANGPDASPLATAQPKKVMGVGFGDIFKEGSVKLKTRLPAPEPEVKKPE-KPLPVQPSGTKVLRSTSSDASRTETDSKPKAKEICKALFNYESVNEDELSFKEGDIIHLTSKETGDPGWWKG-ELNGKEGVFPDNFVAIIQD 334 HSP 2 Score: 99.3673 bits (246), Expect = 7.536e-22 Identity = 66/203 (32.51%), Postives = 103/203 (50.74%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSV-RPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++Y++E+DYDA DELTI GD+I +V + EDGW+ G + GK G FP NF K +KE P+A + +N ++ E K+ L+ TN P+ +++E K K +V++ Y +N DEL L++G+++ + E+ +EGWW G S G+SG+FP NFV+ I
Sbjct: 1 VEYIVEYDYDAVNEDELTIRVGDVIKNVNKLEEDGWLEGEVNGKRGAFPDNFVKEIKEHPG---------PKAAKVSNCRNKSGGCTELVACIKRYL--------------LRATNPPRLPRPLNKESK---------------KRQCKVLYEYIPQNEDELELKVGEVLDII--EEVEEGWWSGSNS-GKSGLFPSNFVKEI 162 HSP 3 Score: 60.8474 bits (146), Expect = 3.752e-9 Identity = 40/105 (38.10%), Postives = 58/105 (55.24%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASK 831
V + Y A N DELT+ +GD+I NK +ED GW G + NG+ G FPDNFV+ IKE + + K+G + A + + + PPR P+ L K++ K
Sbjct: 5 VEYDYDAVNEDELTIRVGDVIKNVNKLEED-GWLEG-EVNGKRGAFPDNFVKEIKEHPGPKAAKVSNCRNKSGGCTELVACIKRYLLRATNPPRLPRPLNKESKK 107
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Match: tmprss9 (transmembrane serine protease 9 [Source:Xenbase;Acc:XB-GENE-993973]) HSP 1 Score: 109.383 bits (272), Expect = 2.290e-24 Identity = 74/213 (34.74%), Postives = 111/213 (52.11%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKP-VKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQT-------PPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVI------SEEVKPEIL-QEKKPKET---TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
+ F Y DEL + G+II + E+GW G+L GK G+FPSNF + V E + E + + + + D +E T K++ G GFG+IF IKL+ + + + +++ +++ P + QE ET T+ K+ +V+ Y A N DELT+ GDI+TV +KE D GWW G + NG+ GVFPDNFV
Sbjct: 43 VAFSYLPQNEDELELKVGEIIEVLGEVEEGWWEGVLNGKTGMFPSNFIREIVTETEIGNFEQQIKTAFKDTTGSESDGGDSKLEGTNGTSGGETQSKRIRGFGFGDIFKDKPIKLRPRSIEMESEIVPIEKAMGKKMPPTVTSQEPMKIETESKTKRKEYCKVLFPYEAMNEDELTIRDGDIVTVLSKECVDAGWWEG-ELNGKKGVFPDNFV 254 HSP 2 Score: 54.299 bits (129), Expect = 5.480e-7 Identity = 29/76 (38.16%), Postives = 45/76 (59.21%), Query Frame = 1
Query: 463 ILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEEN 690
+L ++ + T R + +V SY +N DEL L++G+II V + +EGWW G NG++G+FP NF+ I E
Sbjct: 27 VLYSEQGERTRRRR--CQVAFSYLPQNEDELELKVGEIIEVLG--EVEEGWWEG-VLNGKTGMFPSNFIREIVTET 97
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Match: tmprss9 (transmembrane serine protease 9 [Source:Xenbase;Acc:XB-GENE-993973]) HSP 1 Score: 108.612 bits (270), Expect = 6.202e-24 Identity = 76/220 (34.55%), Postives = 113/220 (51.36%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKE-------DRRKSQEDNLIIP-QAEERNNNTKENDVVIEQT-------PPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVI------SEEVKPEIL-QEKKPKET---TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
+ F Y DEL + G+II + E+GW G+L GK G+FPSNF + + D E +LI Q + + + D +E T K++ G GFG+IF IKL+ + + + +++ +++ P + QE ET T+ K+ +V+ Y A N DELT+ GDI+TV +KE D GWW G + NG+ GVFPDNFV
Sbjct: 107 VAFSYLPQNEDELELKVGEIIEVLGEVEEGWWEGVLNGKTGMFPSNFIREIVTETEIGNFDLSSFLELSLIFHLQNDTTGSESDGGDSKLEGTNGTSGGETQSKRIRGFGFGDIFKDKPIKLRPRSIEMESEIVPIEKAMGKKMPPTVTSQEPMKIETESKTKRKEYCKVLFPYEAMNEDELTIRDGDIVTVLSKECVDAGWWEG-ELNGKKGVFPDNFV 325 HSP 2 Score: 94.3597 bits (233), Expect = 1.727e-19 Identity = 62/209 (29.67%), Postives = 92/209 (44.02%), Query Frame = 1
Query: 64 IFDMDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEEN 690
+ L FDY A DELTI GDII ++ + GW G L+G+ G+FP NF + +K+D +K Q N+K PP + G+ GN E +++ + + +V SY +N DEL L++G+II V + +EGWW G NG++G+FP NF+ I E
Sbjct: 1 MIRFQLLENFDYKAQHEDELTITAGDIITKIKKEDGGWWEGELKGRRGLFPDNFVRELKKDTKKEQ--------------NSK---------PPDRPTQGISNGNALLSSEAVIRSAG----------------------RGERTRRRRCQVAFSYLPQNEDELELKVGEIIEVLG--EVEEGWWEG-VLNGKTGMFPSNFIREIVTET 161 HSP 3 Score: 57.7658 bits (138), Expect = 4.751e-8 Identity = 33/69 (47.83%), Postives = 42/69 (60.87%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNK-PSRPNNA 717
Y A++ DELT+ GDIIT KED GWW G + G+ G+FPDNFV + KE+N+K P RP
Sbjct: 12 YKAQHEDELTITAGDIITKIKKEDG--GWWEG-ELKGRRGLFPDNFVRELKKDTKKEQNSKPPDRPTQG 77
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Match: Sh3kbp1 (SH3-domain kinase binding protein 1 [Source:MGI Symbol;Acc:MGI:1889583]) HSP 1 Score: 122.865 bits (307), Expect = 1.991e-29 Identity = 101/280 (36.07%), Postives = 136/280 (48.57%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLK----TTNKDNKP--KVISEEVKPEILQEKKPKET-----TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N + PKKV GVGFG+IF IKL+ D P K I +++ P P +T T+TKD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A ++K G T K +I K IPP P+ L
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPAT-STPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVVKQG--AGTTERKHEI---KKIPPERPETL 335 HSP 2 Score: 56.225 bits (134), Expect = 8.214e-8 Identity = 26/62 (41.94%), Postives = 41/62 (66.13%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNK 696
+V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E+++
Sbjct: 66 CQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESDE 124
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Match: Sh3kbp1 (SH3-domain kinase binding protein 1 [Source:MGI Symbol;Acc:MGI:1889583]) HSP 1 Score: 124.02 bits (310), Expect = 4.066e-29 Identity = 101/280 (36.07%), Postives = 136/280 (48.57%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLK----TTNKDNKP--KVISEEVKPEILQEKKPKET-----TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N + PKKV GVGFG+IF IKL+ D P K I +++ P P +T T+TKD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A ++K G T K +I K IPP P+ L
Sbjct: 68 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPAT-STPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVVKQG--AGTTERKHEI---KKIPPERPETL 335 HSP 2 Score: 56.9954 bits (136), Expect = 6.806e-8 Identity = 26/61 (42.62%), Postives = 40/61 (65.57%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENN 693
+V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E++
Sbjct: 66 CQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESD 123
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Match: Sh3kbp1 (SH3-domain kinase binding protein 1 [Source:MGI Symbol;Acc:MGI:1889583]) HSP 1 Score: 124.02 bits (310), Expect = 5.978e-29 Identity = 101/280 (36.07%), Postives = 136/280 (48.57%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLK----TTNKDNKP--KVISEEVKPEILQEKKPKET-----TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N + PKKV GVGFG+IF IKL+ D P K I +++ P P +T T+TKD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A ++K G T K +I K IPP P+ L
Sbjct: 105 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPAT-STPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVVKQG--AGTTERKHEI---KKIPPERPETL 372 HSP 2 Score: 97.4413 bits (241), Expect = 1.527e-20 Identity = 61/207 (29.47%), Postives = 96/207 (46.38%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENN 693
++ ++EFDY A DELTI G++I ++R + GW G + G+ G+FP NF + +K+D +K ++ P K + V GN E L+T K R + +V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E++
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDMKKD----------------------LLSNKAPEKPMHDVSSGNALLSSETILRTN-----------------------KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESD 160 HSP 3 Score: 60.4622 bits (145), Expect = 5.837e-9 Identity = 30/63 (47.62%), Postives = 41/63 (65.08%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNA 717
Y A++ DELT+ +G++IT N ED GWW G + NG+ G+FPDNFV IK++ K N A
Sbjct: 10 YQAQHDDELTISVGEVIT--NIRKEDGGWWEG-QINGRRGLFPDNFVREIKKDMKKDLLSNKA 69
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Match: Cd2ap (CD2-associated protein [Source:MGI Symbol;Acc:MGI:1330281]) HSP 1 Score: 115.546 bits (288), Expect = 1.512e-26 Identity = 84/235 (35.74%), Postives = 115/235 (48.94%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPP-----------------PKKVTGVGFGNIFSGGEIKLKTTN--------KDNKPKVIS---------EEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ FDY DEL + GD+I+ + E+GW G L K G+FPSNF VKE +S ED E +N +E++V + T P PKK+ G+GFG+IF G +KL+T K KP ++ E KP++ + K KE RT + YT N DELT G+II + +KE + GWW+G + NG+ GVFPDNF I E
Sbjct: 10 VLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNF---VKE--LESTEDG-------ETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRT------LFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG-ELNGKEGVFPDNFAVQISE 225 HSP 2 Score: 52.373 bits (124), Expect = 1.849e-6 Identity = 24/53 (45.28%), Postives = 35/53 (66.04%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
+V+ Y+ +N DEL L +GD+I V E+ +EGWW G +N + G+FP NFV
Sbjct: 8 CKVLFDYSPQNEDELELIVGDVIDVI--EEVEEGWWSGTLNN-KLGLFPSNFV 57
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Match: Cd2ap (CD2-associated protein [Source:MGI Symbol;Acc:MGI:1330281]) HSP 1 Score: 114.775 bits (286), Expect = 4.344e-26 Identity = 82/235 (34.89%), Postives = 114/235 (48.51%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPP-----------------PKKVTGVGFGNIFSGGEIKLKTTN--------KDNKPKVIS---------EEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ FDY DEL + GD+I+ + E+GW G L K G+FPSNF K + +S ED E +N +E++V + T P PKK+ G+GFG+IF G +KL+T K KP ++ E KP++ + K KE RT + YT N DELT G+II + +KE + GWW+G + NG+ GVFPDNF I E
Sbjct: 115 VLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKEL-----ESTEDG-------ETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRT------LFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG-ELNGKEGVFPDNFAVQISE 330 HSP 2 Score: 92.4337 bits (228), Expect = 5.993e-19 Identity = 65/204 (31.86%), Postives = 103/204 (50.49%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK 681
+DY++E+DYDA DELTI G+II +V+ E+GW+ G L G+ G+FP NF VKE +R+++ + +P ER N V + + +GG ++P + K + K +V+ Y+ +N DEL L +GD+I V E+ +EGWW G +N + G+FP NFV+ ++
Sbjct: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNF---VKEIKRETEPKDDNLPIKRERQGNVA------------SLVQRISTYGLPAGG-------------------IQPH--PQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVI--EEVEEGWWSGTLNN-KLGLFPSNFVKELE 166 HSP 3 Score: 51.6026 bits (122), Expect = 3.612e-6 Identity = 28/57 (49.12%), Postives = 37/57 (64.91%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEE 687
V + Y A + DELT+ +G+II K E EGW G + NG+ G+FPDNFV+ IK E
Sbjct: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQE-EGWLEG-ELNGRRGMFPDNFVKEIKRE 60
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q96B97|SH3K1_HUMAN (SH3 domain-containing kinase-binding protein 1 OS=Homo sapiens OX=9606 GN=SH3KBP1 PE=1 SV=2) HSP 1 Score: 124.02 bits (310), Expect = 3.790e-28 Identity = 99/282 (35.11%), Postives = 137/282 (48.58%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNT--------------------KENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKET-------------TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + + D L I Q E+ + ++ N V PKKV GVGFG+IF IKL+ + + + + E + + +K P T T++KD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A +IK G T K +I K IPP P++L
Sbjct: 105 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELS-----GESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVE---KTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQG--AGTTERKHEI---KKIPPERPEML 372 HSP 2 Score: 92.0485 bits (227), Expect = 5.244e-18 Identity = 62/208 (29.81%), Postives = 96/208 (46.15%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNK 696
++ ++EFDY A DELTI G+II ++R + GW G + G+ G+FP NF + +K++ +K N P K + V GN E L+T K R + +V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E+++
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTN----------------------KAPEKPLHEVPSGNSLLSSETILRTN-----------------------KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESDE 161 HSP 3 Score: 62.003 bits (149), Expect = 1.333e-8 Identity = 32/63 (50.79%), Postives = 41/63 (65.08%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNA 717
Y A++ DELT+ +G+IIT N ED GWW G + NG+ G+FPDNFV IK+E K N A
Sbjct: 10 YQAQHDDELTISVGEIIT--NIRKEDGGWWEG-QINGRRGLFPDNFVREIKKEMKKDPLTNKA 69
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9Y5K6|CD2AP_HUMAN (CD2-associated protein OS=Homo sapiens OX=9606 GN=CD2AP PE=1 SV=1) HSP 1 Score: 117.087 bits (292), Expect = 5.417e-26 Identity = 82/225 (36.44%), Postives = 118/225 (52.44%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK----EDRRKSQEDNLII------PQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPE---ILQEKKPK----ETTRT--------KDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ F+Y DEL + GDII+ E+GW G L K G+FPSNF K ++ + ++Q+D+ + P N + + V + PKK+ G+GFG+IF G +KL+T ++ +EE KPE ILQ PK E T+T K+ R + +Y N DELT + G+II + +KE + GWWRG + NG+ GVFPDNF I E
Sbjct: 115 VLFEYIPQNEDELELKVGDIIDINEEVEEGWWSGTLNNKLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPIPSLGNVSETASGSVTQ----PKKIRGIGFGDIFKEGSVKLRTRTSSSE----TEEKKPEKPLILQSLGPKTQSVEITKTDTEGKIKAKEYCRTLFAYEGTNEDELTFKEGEIIHLISKETGEAGWWRG-ELNGKEGVFPDNFAVQINE 330 HSP 2 Score: 97.0561 bits (240), Expect = 1.452e-19 Identity = 69/229 (30.13%), Postives = 118/229 (51.53%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSR--PNNAAIIKAGPPPPV 750
+DY++E+DYDA DELTI G+II +V+ E+GW+ G L G+ G+FP NF VKE +R+++ + +P ER+ N ++++ G +GG ++P + K + K +V+ Y +N DEL L++GDII + E+ +EGWW G +N + G+FP NFV+ ++ ++ + +++ + AGP P+
Sbjct: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNF---VKEIKRETEFKDDSLPIKRERHGNV---------ASLVQRISTYGLP---AGG-------------------IQPH--PQTKNIKKKTKKRQCKVLFEYIPQNEDELELKVGDIIDIN--EEVEEGWWSGTLNN-KLGLFPSNFVKELEVTDDGETHEAQDDSETVLAGPTSPI 191
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q9JLQ0|CD2AP_MOUSE (CD2-associated protein OS=Mus musculus OX=10090 GN=Cd2ap PE=1 SV=3) HSP 1 Score: 114.775 bits (286), Expect = 3.039e-25 Identity = 82/235 (34.89%), Postives = 114/235 (48.51%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDV-VIEQTPP-----------------PKKVTGVGFGNIFSGGEIKLKTTN--------KDNKPKVIS---------EEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ FDY DEL + GD+I+ + E+GW G L K G+FPSNF K + +S ED E +N +E++V + T P PKK+ G+GFG+IF G +KL+T K KP ++ E KP++ + K KE RT + YT N DELT G+II + +KE + GWW+G + NG+ GVFPDNF I E
Sbjct: 115 VLFDYSPQNEDELELIVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKEL-----ESTEDG-------ETHNAQEESEVPLTGPTSPLPSPGNGSEPAPGSVAQPKKIRGIGFGDIFKEGSVKLRTRTSSSETEEKKTEKPLILQPLGSRTQNVEVTKPDVDGKIKAKEYCRT------LFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG-ELNGKEGVFPDNFAVQISE 330 HSP 2 Score: 92.4337 bits (228), Expect = 4.192e-18 Identity = 65/204 (31.86%), Postives = 103/204 (50.49%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK 681
+DY++E+DYDA DELTI G+II +V+ E+GW+ G L G+ G+FP NF VKE +R+++ + +P ER N V + + +GG ++P + K + K +V+ Y+ +N DEL L +GD+I V E+ +EGWW G +N + G+FP NFV+ ++
Sbjct: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNF---VKEIKRETEPKDDNLPIKRERQGNVA------------SLVQRISTYGLPAGG-------------------IQPH--PQTKAIKKKTKKRQCKVLFDYSPQNEDELELIVGDVIDVI--EEVEEGWWSGTLNN-KLGLFPSNFVKELE 166
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Match: sp|F1LRS8|CD2AP_RAT (CD2-associated protein OS=Rattus norvegicus OX=10116 GN=Cd2ap PE=1 SV=2) HSP 1 Score: 114.005 bits (284), Expect = 5.859e-25 Identity = 79/226 (34.96%), Postives = 113/226 (50.00%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK-------EDRRKSQEDNLIIPQA--EERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTN--------KDNKPKVIS---------EEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ F+Y DEL + GD+I+ + E+GW G L K G+FPSNF K ++ D ++ E +L P + N ++ + Q PKK+ GVGFG+IF G +KL+T K KP ++ E KP+I + K KE +T + YT N DELT G+II + +KE + GWW+G + NG+ GVFPDNF I E
Sbjct: 115 VLFEYSPQNEDELELTVGDVIDVIEEVEEGWWSGTLNNKLGLFPSNFVKELESTDDGEMHDAQEESEVSLTGPTSPMPSPGNGSEPAPGSVTQ---PKKIRGVGFGDIFKEGSVKLRTRTSSSETEEKKSEKPLILQSLGSRTQNVEVTKPDIDGKIKAKEYCKT------VFPYTGTNEDELTFREGEIIHLISKETGEAGWWKG-ELNGKEGVFPDNFAVQISE 330 HSP 2 Score: 91.2781 bits (225), Expect = 8.505e-18 Identity = 65/204 (31.86%), Postives = 103/204 (50.49%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIK 681
+DY++E+DYDA DELTI G+II +V+ E+GW+ G L G+ G+FP NF VKE +R+++ + +P ER N V + + +GG ++P + K + K +V+ Y+ +N DEL L +GD+I V E+ +EGWW G +N + G+FP NFV+ ++
Sbjct: 2 VDYIVEYDYDAVHDDELTIRVGEIIRNVKKLQEEGWLEGELNGRRGMFPDNF---VKEIKRETEPKDDNLPIKRERPGNVA------------SLVQRISTYGLPAGG-------------------IQPH--PQTKAMKKKTKKRQCKVLFEYSPQNEDELELTVGDVIDVI--EEVEEGWWSGTLNN-KLGLFPSNFVKELE 166 HSP 3 Score: 52.7582 bits (125), Expect = 9.244e-6 Identity = 33/78 (42.31%), Postives = 43/78 (55.13%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENN--------KPSRPNNAAII 726
V + Y A + DELT+ +G+II K E EGW G + NG+ G+FPDNFV+ IK E K RP N A +
Sbjct: 6 VEYDYDAVHDDELTIRVGEIIRNVKKLQE-EGWLEG-ELNGRRGMFPDNFVKEIKRETEPKDDNLPIKRERPGNVASL 81
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Match: sp|Q925Q9|SH3K1_RAT (SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus OX=10116 GN=Sh3kbp1 PE=1 SV=2) HSP 1 Score: 111.694 bits (278), Expect = 3.332e-24 Identity = 103/319 (32.29%), Postives = 137/319 (42.95%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK-----------EDRRKSQEDNLI------IPQAEERNNNTKENDVVIEQTP------------------------------------------PPKKVTGVGFGNIFSGGEIKLK----TTNKDNKP--KVISEEVKPEILQEKKPKET-----TRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-----KEENNKPSRPNNAA-IIKAGPPPPVTAAKPKINVGKSIPPRPPQLL 813
+ F Y DEL + GDII V E+GW G+L GK G+FPSNF K + E KS+ + + P + T E ++ P PKKV GVGFG+IF IKL+ D P K I +++ P P +T T+TKD +VI Y A+N DELT++ GDI+T+ NK+ D GWW G + NG+ GVFPDNFV+ + KE N P +A +IK G T K +I K IPP P+ L
Sbjct: 105 VAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPAT-STPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEG-ELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVIKQG--AGTTERKHEI---KKIPPERPETL 416 HSP 2 Score: 96.2857 bits (238), Expect = 2.785e-19 Identity = 70/251 (27.89%), Postives = 110/251 (43.82%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGP---------PPPVTAAKPKINVGKSIPPR 798
++ ++EFDY A DELTI G++I ++R + GW G + G+ G+FP NF + +K+D +K ++ P K + V GN E L+T K R + +V SY +N DEL L++GDII V + +EGWW G NG++G+FP NF++ + E+++ + + K+ P P P AK K +I R
Sbjct: 2 VEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDVKKD----------------------LLSNKAPEKPMHDVSSGNSLLSSETILRTN-----------------------KRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVG--EVEEGWWEG-VLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYR 204
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Match: A0A4E0RWI9 (SH3 domain-containing kinase-binding protein 1 OS=Fasciola hepatica OX=6192 GN=D915_006853 PE=4 SV=1) HSP 1 Score: 145.591 bits (366), Expect = 4.197e-34 Identity = 98/256 (38.28%), Postives = 136/256 (53.12%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLII-----PQAEERN-NNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTN--------KDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRK-SNGQSGVFPDNFVEPIKEE-NNKPSRPNNAAI--IKAGPPPPVTAAKPKINVGKS 786
M+ L+EFDY A+E DELTI KGDII V E+GW G L GK GVFP NF K ++ ++ ++ P+AE + T+ + + T +KVTG+G GNIFSG I+L+ T+ + N K +S ++ ++TRT D VR Y + DEL L + DII + ++ DEGWW+G+ + + GVFPDNFV P+ E N+ R N A P PP AAKP +G S
Sbjct: 1 MEVLVEFDYAAEEPDELTIKKGDIIKDVSQFEEGWYIGNLNGKVGVFPDNFVKTIESSAGSKKQTIPVVETVKEPRAESKKVTETESEENRLGSTAKSQKVTGIGLGNIFSGQPIQLRQTSLKEVIKDTESNTDKTVSS------VKGDGSNQSTRT-DHVRARFDYQPKQLDELELHVDDIIQILDRNLPDEGWWKGKNLTTKKIGVFPDNFVIPVTEVPNDAVDRTQNTASTNTNTAPEPPKVAAKPSPLLGNS 249
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Match: A0A2C9JR72 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106064565 PE=4 SV=1) HSP 1 Score: 138.272 bits (347), Expect = 2.054e-30 Identity = 116/345 (33.62%), Postives = 168/345 (48.70%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTT-----NKDNKPKVISE-EVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-KEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPA-NTVKDDGISFD-------APVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTT--PAIKLKP 1074
F+Y + DEL + GDII + E+GW G L GK GVFPSNF + + E++ S E + +++ + ++ D Q KK+ GVG GNIF GG IKL+ T +D K E E+ PE+ K+ K+ T + +VR SY AE DEL+L G II + +KE EDEGWW+G + +G+ GVFPDNFVE + EE +KP + PP P K + P ++ EK + + +K + ISF V H P G+ + ++L + V + DEDS + R +S I + P+I KP
Sbjct: 113 FEYKKENDDELELQVGDIIEFHKQVEEGWWEGSLNGKHGVFPSNFVEMI-EEQSSSDESGQTNSEDKDKTSESQGKDENF-QAIKGKKIVGVGLGNIFGGGPIKLRPTADSGKKEDGKSGSKGEPEITPEVA--KREKQNTFERAIVRF--SYNAEQPDELSLVEGQIIRILDKELEDEGWWKG-ELHGKVGVFPDNFVELLPNEETSKPKK----------PPLPTNTTKQSV---------PVKVSEKSMLDSSDDKIKAENISFSNARKGKKYSVTHSSRHSPGLGKRSQMSRELSCILEAV-----EQMRDEDSMVLYRPDSRSKIHYYYESLGPSITKKP 426 HSP 2 Score: 61.2326 bits (147), Expect = 6.099e-6 Identity = 27/56 (48.21%), Postives = 39/56 (69.64%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK 240
++ ++EF+Y A++ DEL++ GDII +V E GW G L GK+G+FP NF K VK
Sbjct: 7 VEAVVEFEYQAEQEDELSLKVGDIITNVVTAEGGWWEGELNGKKGMFPENFVKLVK 62
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Match: A0A2C9JR75 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106064565 PE=4 SV=1) HSP 1 Score: 137.502 bits (345), Expect = 5.731e-30 Identity = 116/347 (33.43%), Postives = 169/347 (48.70%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTT-----NKDNKPKVISE-EVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-KEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPA-NTVKDDGISFD-------APVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTT--PAIKLKP 1074
+ F+Y + DEL + GDII + E+GW G L GK GVFPSNF + + E++ S E + +++ + ++ D Q KK+ GVG GNIF GG IKL+ T +D K E E+ PE+ K+ K+ T + +VR SY AE DEL+L G II + +KE EDEGWW+G + +G+ GVFPDNFVE + EE +KP + PP P K + P ++ EK + + +K + ISF V H P G+ + ++L + V + DEDS + R +S I + P+I KP
Sbjct: 111 VLFEYKKENDDELELQVGDIIEFHKQVEEGWWEGSLNGKHGVFPSNFVEMI-EEQSSSDESGQTNSEDKDKTSESQGKDENF-QAIKGKKIVGVGLGNIFGGGPIKLRPTADSGKKEDGKSGSKGEPEITPEVA--KREKQNTFERAIVRF--SYNAEQPDELSLVEGQIIRILDKELEDEGWWKG-ELHGKVGVFPDNFVELLPNEETSKPKK----------PPLPTNTTKQSV---------PVKVSEKSMLDSSDDKIKAENISFSNARKGKKYSVTHSSRHSPGLGKRSQMSRELSCILEAV-----EQMRDEDSMVLYRPDSRSKIHYYYESLGPSITKKP 426 HSP 2 Score: 61.2326 bits (147), Expect = 7.135e-6 Identity = 27/56 (48.21%), Postives = 39/56 (69.64%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK 240
++ ++EF+Y A++ DEL++ GDII +V E GW G L GK+G+FP NF K VK
Sbjct: 7 VEAVVEFEYQAEQEDELSLKVGDIITNVVTAEGGWWEGELNGKKGMFPENFVKLVK 62
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Match: A0A2C9JR83 (Uncharacterized protein OS=Biomphalaria glabrata OX=6526 GN=106064565 PE=4 SV=1) HSP 1 Score: 137.502 bits (345), Expect = 6.068e-30 Identity = 116/345 (33.62%), Postives = 168/345 (48.70%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTT-----NKDNKPKVISE-EVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI-KEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPA-NTVKDDGISFD-------APVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTT--PAIKLKP 1074
F+Y + DEL + GDII + E+GW G L GK GVFPSNF + + E++ S E + +++ + ++ D Q KK+ GVG GNIF GG IKL+ T +D K E E+ PE+ K+ K+ T + +VR SY AE DEL+L G II + +KE EDEGWW+G + +G+ GVFPDNFVE + EE +KP + PP P K + P ++ EK + + +K + ISF V H P G+ + ++L + V + DEDS + R +S I + P+I KP
Sbjct: 113 FEYKKENDDELELQVGDIIEFHKQVEEGWWEGSLNGKHGVFPSNFVEMI-EEQSSSDESGQTNSEDKDKTSESQGKDENF-QAIKGKKIVGVGLGNIFGGGPIKLRPTADSGKKEDGKSGSKGEPEITPEVA--KREKQNTFERAIVRF--SYNAEQPDELSLVEGQIIRILDKELEDEGWWKG-ELHGKVGVFPDNFVELLPNEETSKPKK----------PPLPTNTTKQSV---------PVKVSEKSMLDSSDDKIKAENISFSNARKGKKYSVTHSSRHSPGLGKRSQMSRELSCILEAV-----EQMRDEDSMVLYRPDSRSKIHYYYESLGPSITKKP 426 HSP 2 Score: 61.2326 bits (147), Expect = 7.484e-6 Identity = 27/56 (48.21%), Postives = 39/56 (69.64%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK 240
++ ++EF+Y A++ DEL++ GDII +V E GW G L GK+G+FP NF K VK
Sbjct: 7 VEAVVEFEYQAEQEDELSLKVGDIITNVVTAEGGWWEGELNGKKGMFPENFVKLVK 62
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Match: A0A0L8H4C0 (Uncharacterized protein (Fragment) OS=Octopus bimaculoides OX=37653 GN=OCBIM_22022992mg PE=4 SV=1) HSP 1 Score: 127.487 bits (319), Expect = 9.149e-30 Identity = 85/205 (41.46%), Postives = 115/205 (56.10%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTK-----ENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVI--HSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++F+Y + DEL +H GD++ R E+GW G L GK G+FPSNF ++E+ P EER + K + D I+ KKV GVGFGNIF G IKL+ ++ K + +EE K E + ++K + I SY AEN DELTL+ GD IT+ K+ ED GWW+G + NG+ GVFPDNFVE I
Sbjct: 12 VQFEYIPEAEDELELHIGDVLEVYREVEEGWWEGQLNGKVGMFPSNF-VEIREN-----------PDEEEREKSVKTDEPEKKDSSIDPETKGKKVKGVGFGNIFGSGPIKLRPSSGVWKGE--TEESKVEKVSGSASTTVKKSKQLEMAIARFSYHAENEDELTLKEGDTITILKKDLEDVGWWKG-ELNGRIGVFPDNFVEII 201
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Match: sh3kbp1 (SH3-domain kinase binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-091204-186]) HSP 1 Score: 110.153 bits (274), Expect = 1.018e-24 Identity = 78/220 (35.45%), Postives = 112/220 (50.91%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK---------EDRRKSQ---EDNLIIPQAEERNNNTKEN--DVVIEQTPPPKKVTGVGFGNIFSGGEIKLK--TTNKDNK-----------PKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
F Y DEL + GD+I+ + E+GW G L GK G+FPSNF K + ED R ++ +D+ +++ + + V PKKV G GFG+IF IKL+ + + DN+ P V E +K E P R K+ +V+ Y A+N DEL+++ G+I+T+ NKE D GWW G + NG+ GVFPDNFV
Sbjct: 125 FSYIPQNEDELELKIGDVIDILGEVEEGWWEGSLSGKTGMFPSNFTKEILAEEEELATPEDTRSTKTSVKDSTGSESDGGDSSSARSDAGSVASSTEIQPKKVRGFGFGDIFKDQPIKLRPRSVDMDNELEKQPTAKKAAPAVAPETMKTE------PDNKARAKEFCKVLFPYDAQNEDELSIKEGEIVTIINKECADAGWWLG-ELNGKQGVFPDNFV 337 HSP 2 Score: 91.2781 bits (225), Expect = 1.122e-18 Identity = 59/200 (29.50%), Postives = 93/200 (46.50%), Query Frame = 1
Query: 67 FDMDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNF 666
F ++ ++EFDY A DELTI G+II+++R E GW G + G+ G+FP NF + +K++ K+ + QT PK + + G+ G + L+ K + + K + SY +N DEL L+IGD+I + + +EGWW G S G++G+FP NF
Sbjct: 17 FSVEAIVEFDYQAQHDDELTISVGEIISNIRKDEGGWWEGEVDGRRGLFPDNFVREIKKE--------------------VKKEASLASQTAGPK--SDLSNGSTSPGSDSCLRPAKKGDAIR----------------------KRRCKAAFSYIPQNEDELELKIGDVIDILG--EVEEGWWEGSLS-GKTGMFPSNF 169 HSP 3 Score: 55.4546 bits (132), Expect = 1.468e-7 Identity = 30/70 (42.86%), Postives = 45/70 (64.29%), Query Frame = 1
Query: 529 YTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGP 738
Y A++ DELT+ +G+II+ N ++ GWW G + +G+ G+FPDNFV IK+E K + + A AGP
Sbjct: 27 YQAQHDDELTISVGEIIS--NIRKDEGGWWEG-EVDGRRGLFPDNFVREIKKEVKKEA---SLASQTAGP 90
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Match: sh3d21 (SH3 domain containing 21 [Source:NCBI gene;Acc:103034682]) HSP 1 Score: 106.301 bits (264), Expect = 7.001e-24 Identity = 75/241 (31.12%), Postives = 117/241 (48.55%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGK----------------------PVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFG--------NIFSGGEIK-------LKTTNKDNKPKVISEEVKPEILQEKKP-KETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
M+ L+ D++ DEL++ GD++ +V+ EDGW+ G LRGK G+FPSNF K P+K+ RK + +PQ E+ E D+ + +T + G+ F +K L+ +K ++PK+ E Q++ ++ T K+ +V+ YTA DEL L+ GDI+T+ +K ED+GWW G + NG+ G FPDNFV I
Sbjct: 1 MEVLVLIDFEGTLGDELSVQAGDVVKNVKAASEDGWLEGELRGKRGIFPSNFVKEVPVHLMGDSKREPRSMRTSKMPLKDLCRKCEVTYTYMPQNED------ELDLAVGETVEILREIEDGWWMGKKNNKIGAFPSNFVKEIFPKDGLQHESK-SRPKLSDSLFTKEAPQQRASIRKKTNVKECCQVMFDYTAVAEDELNLKKGDIVTIISKASEDDGWWEG-ELNGRRGFFPDNFVMVI 233
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Match: cd2ap (CD2 associated protein [Source:NCBI gene;Acc:103029908]) HSP 1 Score: 102.064 bits (253), Expect = 4.319e-22 Identity = 77/221 (34.84%), Postives = 113/221 (51.13%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERN---NNTKENDVVIEQTPPPKKVTGVGFGNIFSGG---EIKLKTTNKDNKPKVI---SEEVKPEILQ-------EKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKP 699
+ F+Y DEL + GDII E+GW G + GK G+FPSNF K V+ + + D P +++ + + VI Q PKKV GVGFG+IF +++L + +D K K I KP L EK + + K+ + +Y A N DEL ++ GD+I + +K+ + GWWRG S G+ GVFPDNFV + E + +P
Sbjct: 138 VVFEYVPQNEDELELKVGDIIEITEEVEEGWWSGSMNGKSGLFPSNFVKEVEMNEEEEISDVPDDPDSKDEAMSPTSPHPGNGVIAQ---PKKVKGVGFGDIFRDSVKLKVRLPSETEDKKEKPIPSLPSAAKPTNLSTSDAQKLEKDGESKGKVKEYCKATFAYEATNQDELDIKEGDVIHLLSKDTGEPGWWRGELS-GKQGVFPDNFVVLLSESDKEP 354 HSP 2 Score: 53.9138 bits (128), Expect = 4.587e-7 Identity = 29/60 (48.33%), Postives = 40/60 (66.67%), Query Frame = 1
Query: 103 ADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGK-----PVKEDRRKSQE 264
A DELT+ +GDII +VR E+GWM G L G+ G+FP NF K PVKE+ ++++E
Sbjct: 12 AAHEDELTLRQGDIIKNVRRIEEEGWMEGDLNGRRGLFPDNFVKEVRKEPVKEEVKEAKE 71
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Match: cd2ap (CD2 associated protein [Source:NCBI gene;Acc:103029908]) HSP 1 Score: 99.3673 bits (246), Expect = 2.733e-21 Identity = 76/218 (34.86%), Postives = 111/218 (50.92%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERN---NNTKENDVVIEQTPPPKKVTGVGFGNIFSGG---EIKLKTTNKDNKPKVI---SEEVKPEILQ-------EKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEEN 690
+ F+Y DEL + GDII E+GW G + GK G+FPSNF K V+ + + D P +++ + + VI Q PKKV GVGFG+IF +++L + +D K K I KP L EK + + K+ + +Y A N DEL ++ GD+I + +K+ + GWWRG S G+ GVFPDNFV + E +
Sbjct: 102 VVFEYVPQNEDELELKVGDIIEITEEVEEGWWSGSMNGKSGLFPSNFVKEVEMNEEEEISDVPDDPDSKDEAMSPTSPHPGNGVIAQ---PKKVKGVGFGDIFRDSVKLKVRLPSETEDKKEKPIPSLPSAAKPTNLSTSDAQKLEKDGESKGKVKEYCKATFAYEATNQDELDIKEGDVIHLLSKDTGEPGWWRGELS-GKQGVFPDNFVVLLSESD 315 HSP 2 Score: 67.3958 bits (163), Expect = 2.748e-11 Identity = 58/192 (30.21%), Postives = 82/192 (42.71%), Query Frame = 1
Query: 103 ADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNF--GKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
A DELT+ +GDII +VR E+GWM G L G+ G+FP NF K VKE R +L+ ++++ G G + + K + KV+ E Y +N DEL L++GD + E+ +EGWW G NG+SG+FP NFV
Sbjct: 12 AAHEDELTLRQGDIIKNVRRIEEEGWMEGDLNGRRGLFPDNFVKTKEVKERRSAGNVASLV------------------------QRISTYGIPTGGLGFQPRSSKKKKKRQCKVVFE---------------------------YVPQNEDELELKVGD--IIEITEEVEEGWWSG-SMNGKSGLFPSNFV 149
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Match: itsn1 (intersectin 1 (SH3 domain protein) [Source:ZFIN;Acc:ZDB-GENE-030616-226]) HSP 1 Score: 70.8626 bits (172), Expect = 3.837e-12 Identity = 57/211 (27.01%), Postives = 94/211 (44.55%), Query Frame = 1
Query: 79 YLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKED-----------RRKSQEDNLIIPQ---AEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
Y+ + Y+++E +LT +GD+I ++ D W G + GK GVFPSN+ KP D +K + +I P E+ ++I + P G G + + G+ + N K++S +++ ++ Y A+N DEL G II V ++ED D WW+G + NG G+FP N+V
Sbjct: 859 YIAMYTYESNEQGDLTFQQGDVITVLKKEGDWWT-GTVSGKTGVFPSNYVKPKDSDGLGPAGKTGSLGKKPEIAQVIAPYTATGAEQLTLAPGQLILIRKKNP----GGWWEGELQARGKKRQIGWFPANYVKLLSPSTMCQVIG----------------MYDYAAQNDDELPFGKGQIINVLSREDPD--WWKG-ELNGSVGLFPSNYV 1045
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008112.1 (pep scaffold:Pmarinus_7.0:GL482163:8897:24902:-1 gene:ENSPMAG00000007333.1 transcript:ENSPMAT00000008112.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 66.6254 bits (161), Expect = 1.267e-12 Identity = 40/115 (34.78%), Postives = 64/115 (55.65%), Query Frame = 1
Query: 499 TKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVE----PIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASK 831
++ + + SY A+N+DEL+L+ G+++ + K+ D GWW G + NG+ GVFPDNFV+ +++E KP + PP+ A K+N+G P P+L KQ K
Sbjct: 1 AREYCKALFSYEAQNNDELSLKEGELVEIIAKDCGDAGWWEG-EVNGKRGVFPDNFVKLLPAEVEKEYEKPKK------------PPLPATLVKVNLGDK--PERPELPFKQEEK 100
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003067.1 (pep scaffold:Pmarinus_7.0:GL477025:38822:89389:-1 gene:ENSPMAG00000002795.1 transcript:ENSPMAT00000003067.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 58.5362 bits (140), Expect = 2.379e-9 Identity = 38/92 (41.30%), Postives = 51/92 (55.43%), Query Frame = 1
Query: 508 VVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVT--AAKPKINV 777
VVR ++ N DEL+ E GD+ITVT E GWW G NG +G FP N+V +K +++P+ P A K G PP + AAK +V
Sbjct: 170 VVRAKFTFQRTNEDELSFEKGDVITVTRV--EHGGWWEG-AFNGHTGWFPSNYVRELK-ASDRPTSP-KAVGSKGGAKPPESPPAAKGYYDV 256
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Match: grb2a (growth factor receptor-bound protein 2a [Source:ZFIN;Acc:ZDB-GENE-041121-1]) HSP 1 Score: 55.8398 bits (133), Expect = 4.702e-9 Identity = 56/231 (24.24%), Postives = 99/231 (42.86%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHED-GWMYGILRGKEGVFPSNF--GKPVKEDRRKSQEDNLIIPQ--AEERNNNTKENDVVI---EQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKP----EILQEKKPKETTRTKDV---------------VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
M+ + ++D++A DEL+ +GD++ + D W L G++G P N+ KP K IP+ AEE N K + + ++ P V FGN +++ +D K VK E+++ + +RT+ + V+ + + + EL GD ITV + D + WW+G +G++G+FP N+V K+
Sbjct: 1 MEAVAKYDFNATAEDELSFKRGDVLKVLNEDCDQNWYKAELNGRDGFIPKNYIDMKPHPWFTGK-------IPRVKAEEMLNRQKFDGAFLVRESESAPGDFSLSVKFGN-----DVQHFKVLRDGAGKYFLWVVKFNSLNELVEYHRSTSVSRTQQIFLRDMEQLPQQAATRVQALFDFEPQEDGELGFRRGDFITVVDSSDPN--WWKG-SCHGRAGMFPRNYVTLAKD 216
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Match: ABI1 (abl interactor 1 [Source:HGNC Symbol;Acc:HGNC:11320]) HSP 1 Score: 56.225 bits (134), Expect = 1.608e-8 Identity = 24/61 (39.34%), Postives = 36/61 (59.02%), Query Frame = 1
Query: 61 KIFDMDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKE 243
KI+ + +DY D+ DEL+ H+G II VR ++DGW G G G+FP N+ +P+
Sbjct: 391 KIYIEKVVAVYDYVQDKDDELSFHEGSIIYVVRKNDDGWYEGATNGHTGLFPGNYVEPIMH 451 HSP 2 Score: 51.9878 bits (123), Expect = 3.520e-7 Identity = 24/58 (41.38%), Postives = 34/58 (58.62%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
V ++ Y + DEL+ G II V K D+ GW+ G +NG +G+FP N+VEPI
Sbjct: 397 VVAVYDYVQDKDDELSFHEGSIIYVVRKNDD--GWYEG-ATNGHTGLFPGNYVEPIMH 451
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009021.1 (pep scaffold:Pmarinus_7.0:GL482604:596:7954:-1 gene:ENSPMAG00000008160.1 transcript:ENSPMAT00000009021.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 55.0694 bits (131), Expect = 2.023e-8 Identity = 23/54 (42.59%), Postives = 33/54 (61.11%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRR 252
FD+ + DEL+ KGD+I RP + GW G L G+ G FPSN+ + +K + R
Sbjct: 16 FDFQRNNEDELSFSKGDVITVTRPEDGGWWEGTLGGRSGWFPSNYVRELKGNER 69 HSP 2 Score: 51.6026 bits (122), Expect = 2.767e-7 Identity = 29/65 (44.62%), Postives = 37/65 (56.92%), Query Frame = 1
Query: 508 VVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPS 702
VVR + N DEL+ GD+ITVT ED GWW G G+SG FP N+V +K N +P+
Sbjct: 11 VVRARFDFQRNNEDELSFSKGDVITVTRP--EDGGWWEG-TLGGRSGWFPSNYVRELK-GNERPT 71
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Match: LSB3 (Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication [Source:SGD;Acc:S000002968]) HSP 1 Score: 53.9138 bits (128), Expect = 4.997e-8 Identity = 22/54 (40.74%), Postives = 32/54 (59.26%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
++S+ E S +L GD+IT+ K D WW GR NG+ G+FP N+VE +
Sbjct: 407 ALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGR-VNGREGIFPANYVELV 459
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Match: YSC84 (Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication [Source:SGD;Acc:S000001058]) HSP 1 Score: 48.9062 bits (115), Expect = 1.671e-6 Identity = 19/52 (36.54%), Postives = 31/52 (59.62%), Query Frame = 1
Query: 517 VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVE 672
++++ E +L + GD+IT+ K D WW GR +NG+ G+FP N+V
Sbjct: 416 ALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGR-TNGKEGIFPANYVR 466
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Match: HSE1 (Subunit of the endosomal Vps27p-Hse1p complex; complex is required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994]) HSP 1 Score: 48.1358 bits (113), Expect = 3.352e-6 Identity = 23/56 (41.07%), Postives = 31/56 (55.36%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
VR ++ T DEL+ GD+ITV + D WW+G G G+FP N+V PI
Sbjct: 222 VRALYDLTTNEPDELSFRKGDVITVLEQVYRD--WWKG-ALRGNMGIFPLNYVTPI 274 HSP 2 Score: 46.595 bits (109), Expect = 9.646e-6 Identity = 19/49 (38.78%), Postives = 27/49 (55.10%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPV 237
+D +E DEL+ KGD+I + W G LRG G+FP N+ P+
Sbjct: 226 YDLTTNEPDELSFRKGDVITVLEQVYRDWWKGALRGNMGIFPLNYVTPI 274
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Match: RVS167 (Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin [Source:SGD;Acc:S000002796]) HSP 1 Score: 47.7506 bits (112), Expect = 4.294e-6 Identity = 19/56 (33.93%), Postives = 32/56 (57.14%), Query Frame = 1
Query: 505 DVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVE 672
+ V ++ Y A+ + +L+ G +I + + + WW GR NGQ GVFP N+V+
Sbjct: 424 ETVTALYDYQAQAAGDLSFPAGAVIEIVQRTPDVNEWWTGR-YNGQQGVFPGNYVQ 478
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Match: LSB1 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368]) HSP 1 Score: 46.595 bits (109), Expect = 5.354e-6 Identity = 28/86 (32.56%), Postives = 46/86 (53.49%), Query Frame = 1
Query: 499 TKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAA---IIKAGPPPP 747
T++ V ++ + A+ +L+L+ GD I V K D W+RG KSN + G+FP N+V+P + P A+ + + PPP
Sbjct: 54 TEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPD--WYRG-KSNNKIGIFPANYVKPAFTRSASPKSAEAASSSTVSRPSVPPP 136
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Match: EDO38710 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC74]) HSP 1 Score: 65.855 bits (159), Expect = 2.993e-12 Identity = 68/217 (31.34%), Postives = 101/217 (46.54%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNF-------GKPVKEDRRKSQEDNLIIPQAEERNNNTKEN---DVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVI-SEEVKPEILQEKKPKETTRTKD--------VVR--VIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
F+Y+A E DEL++ DII + + GW G L GK+G+FP NF + K + S + L+ + + K D E VTG+ N+ E D + V S VK + + E P +T R + V+R V + Y +N DEL L++GDIIT+ KE D W + +G++G+FPDNFVE +
Sbjct: 1 FEYEAAEPDELSLQIDDIIEDIVDEDVGWARGDLNGKKGLFPVNFVDFIENNAELAKSAGKASYKRKLLSFSSTDSIAGRKACVLFDYEAENADELSLVTGIEI-NVIREVEDGWWEGTVDGRKGVFPSNFVKLKPIDET-PTKTKRQPEKQPPAEEPVLRAKVTYDYEQQNEDELELKVGDIITIVKKEVFDTPGWMEGELDGKTGLFPDNFVEIL 215
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Match: EDO29744 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2S0]) HSP 1 Score: 59.3066 bits (142), Expect = 1.487e-9 Identity = 57/210 (27.14%), Postives = 98/210 (46.67%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKS--QEDNLIIPQAEERNNNTKENDVVIEQ-TPPPKKV--------TGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTR---TKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+ Y+ +E D L+ +GD+I + E W G LR G+FP+N+ K KE RKS ++L +E + + +Q + P ++ +G G + + G+ + N K++++ P Q T + + V + YTA+ DELT G + V +K+ E WW+G + NGQ G+FP N+V+ +
Sbjct: 6 YTYNGEEGD-LSFKEGDVIG-ITKDEGEWWEGRLRENYGLFPANYVKK-KEAERKSTLSLNSLFCLFSEIATVVSPYTAIAADQLSLAPGQLIRVTRKDPSGWWEGELQARGKKRQSGIFPANHVKILAK--GPGGSQSGSCTSTQQPPEGGNQVLAMFPYTAQKGDELTFYKGSVFNVMSKDGE---WWKG-ELNGQVGMFPSNYVQSL 206
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Match: EDO43872 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RXM7]) HSP 1 Score: 58.151 bits (139), Expect = 6.775e-9 Identity = 28/56 (50.00%), Postives = 36/56 (64.29%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+ I+ Y A SDELT+ GDIITVT + D GWW+G N Q G+FP ++VE I
Sbjct: 439 CKAIYDYQATQSDELTIHPGDIITVTAR--LDNGWWQG-DLNNQQGIFPASYVEEI 491 HSP 2 Score: 52.373 bits (124), Expect = 4.021e-7 Identity = 20/45 (44.44%), Postives = 31/45 (68.89%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNF 225
+DY A ++DELTIH GDII ++GW G L ++G+FP+++
Sbjct: 443 YDYQATQSDELTIHPGDIITVTARLDNGWWQGDLNNQQGIFPASY 487
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Match: EDO41303 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4L5]) HSP 1 Score: 51.2174 bits (121), Expect = 1.064e-8 Identity = 22/53 (41.51%), Postives = 36/53 (67.92%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
V V++ Y A +DELT+ GD+ITV +++E+ WW G ++G+ G FP N++
Sbjct: 1 VLVMYPYEANRADELTITPGDVITVLYQDNEN--WWMGELADGRQGYFPSNYI 51 HSP 2 Score: 45.4394 bits (106), Expect = 9.777e-7 Identity = 21/49 (42.86%), Postives = 34/49 (69.39%), Query Frame = 1
Query: 82 LIEFDYDADEADELTIHKGDIINSV-RPHEDGWMYGILRGKEGVFPSNF 225
L+ + Y+A+ ADELTI GD+I + + +E+ WM + G++G FPSN+
Sbjct: 2 LVMYPYEANRADELTITPGDVITVLYQDNENWWMGELADGRQGYFPSNY 50
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Match: EDO31290 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYD1]) HSP 1 Score: 55.4546 bits (132), Expect = 1.442e-8 Identity = 31/75 (41.33%), Postives = 42/75 (56.00%), Query Frame = 1
Query: 454 KPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
+PE L E P E T ++ Y + +E+T + DIIT N E DEGWWRG +G+ G+FP N+VE I
Sbjct: 174 EPEDLYENAPAEDTGV--TATALYDYQQADDNEITFDPDDIIT--NIEQIDEGWWRGTGPDGRHGMFPANYVEII 244
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Match: sh3kbp1 (SH3 domain containing kinase binding protein 1 [Source:NCBI gene;Acc:101157013]) HSP 1 Score: 120.553 bits (301), Expect = 3.384e-28 Identity = 86/268 (32.09%), Postives = 129/268 (48.13%), Query Frame = 1
Query: 91 FDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGK-------------PVKEDRRKSQEDNLI---IPQAEERNNNTK-ENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVI----SEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASK 831
F Y DEL + GD+I + E+GW G+L GK G+FPSNF + P D +SQ P +E +++ E I PKKV G GFG IF IKL+ + + P+ + + V E ++ +P ++ ++ +V+ Y A+N DELTL+ GDII + K+ D GWW G + G+ GVFPDNFV K++ N+ ++ A PP K V K+ P RP L ++ + +
Sbjct: 88 FSYAPQHEDELELRVGDVIEIITEVEEGWWEGVLNGKTGMFPSNFTREIAAESDMPLADTPTSHDELRSQTSETTSKDSPGSESDGGDSRSETGSEIH----PKKVKGFGFGEIFKDQVIKLRPRSIEVDPEGVKVRKASSVATETMK-TEPDTKSKGREQCKVLFPYEAQNEDELTLKEGDIINIITKDCADAGWWMG-EFGGRQGVFPDNFV---KDQRNR--------LLPAHHPPSTPWVTKKSEVKKAPPERPEHLPQRDSDR 338
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Match: cd2ap (CD2 associated protein [Source:NCBI gene;Acc:101154913]) HSP 1 Score: 104.76 bits (260), Expect = 5.548e-23 Identity = 73/220 (33.18%), Postives = 105/220 (47.73%), Query Frame = 1
Query: 85 IEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVK-------------EDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLK---TTNKDNKPKVISEEVKPEILQEKKPKETT----RTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
+ FDY DEL + KGD+I E+GW G L GK G+FPSNF K + +D S D P + + + + I Q PKKV G+G+IF KLK + KP + P + K K+ + K+ RV+ ++ + DEL+L+ GDI+ + +K+ + GWWRG + G+ GVFPDNFV I E
Sbjct: 121 VLFDYQPQNEDELELKKGDLIEITEEVEEGWWSGSLNGKSGLFPSNFVKEMDAAGEDVESSDATPDDAEGSGTDGATTPTSPQSASGSG----AIAQ---PKKVQRFGYGDIFKESSFKLKPVPSLPSSAKPTPPNTTEPPRAEADAKLKDASVSVPSAKEFCRVMFAFEGTHEDELSLKEGDIVQILSKDTGETGWWRG-EIGGERGVFPDNFVVVISE 332 HSP 2 Score: 98.5969 bits (244), Expect = 5.789e-21 Identity = 73/208 (35.10%), Postives = 106/208 (50.96%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRP-HEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQ--------EDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
M+ L+EFDY+A DELT+ GD+I +VR EDGWM G L GK GVFP NF K +K+++ + ++ +PQ E++ + N V ++++ +GF T P + KKPK K +V+ Y +N DEL L+ GD+I +T E+ +EGWW G NG+SG+FP NFV
Sbjct: 1 MEVLVEFDYEALHDDELTLRPGDVIRNVRYIEEDGWMEGDLNGKRGVFPDNFVKEIKKEKEPKEVKETKHEPKEETSVPQKREKSAHVA-NLV--------QRMSTIGF------------PTGGFQPPTTV-----------KKPK-----KRHCKVLFDYQPQNEDELELKKGDLIEIT--EEVEEGWWSG-SLNGKSGLFPSNFV 168
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Match: sh3d21 (SH3 domain containing 21 [Source:NCBI gene;Acc:101167234]) HSP 1 Score: 99.3673 bits (246), Expect = 1.352e-21 Identity = 69/236 (29.24%), Postives = 114/236 (48.31%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDII-NSVRPHEDGWMYGILRGKEGVFPSNFGKPV---------KEDR--------RKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIK----------------LKTTNKDNKPKVISEEVKPEILQEKKPKETTRTK---DVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
M+ L+ D++ DELT+ GD++ N + +E+GW++G LRGK G+FP NF K + +E R ++ ++ +I P + N E ++V+ +T + G+ ++ LK ++PK+ EI +KP + K + +V+ Y A++ DEL L+ GD++ + KE EDEGWW G + NG+ G FPDNFV
Sbjct: 1 MEVLVLMDFEGTAGDELTVKTGDVLKNVTKANEEGWLHGELRGKWGIFPVNFVKEIPVYLIGDSKREPRSIRKPKKVKQVRKCEVIFPYCPQ---NDDELELVVGETIEIIREIEDGWWMGVRNAKVGAFPSNFVTEIIFPPKDLKQIEGKSRPKLSDAMFTKEI--SRKPSVRSHAKTNVEYCQVMFDYKAQSEDELDLKKGDVVVLLRKETEDEGWWEG-ELNGRCGFFPDNFV 230
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Match: ENSORLT00000029133.1 (pep primary_assembly:ASM223467v1:15:615592:625392:1 gene:ENSORLG00000023954.1 transcript:ENSORLT00000029133.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 81.2629 bits (199), Expect = 2.727e-17 Identity = 61/211 (28.91%), Postives = 94/211 (44.55%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVI------------HSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
++YL + Y++ E +L+ +GDI+ R D W G + GK GVFPSN+ KP R + E + ++ + +K+T F + SG T +D K + EEV + + T V + + Y A+N DEL G +ITV NKED D WW+G + NG+ G+FP N++
Sbjct: 1 VEYLAMYTYESSEQGDLSFQQGDIVMVTRKEGDWWT-GTVGGKTGVFPSNYVKP----RDSAMEVRALF---------------FLQWSGLDQKLTVFPFLSSVSG------TCRQDRKSR---EEVGDHCFMCFRALGFSLTSRCVLTLCLSAAVCQVIGMYDYVAQNDDELAFLKGQVITVLNKEDCD--WWKG-ELNGREGLFPSNYL 179
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Match: pacsin1a (protein kinase C and casein kinase substrate in neurons 1 [Source:NCBI gene;Acc:101164231]) HSP 1 Score: 63.1586 bits (152), Expect = 3.720e-10 Identity = 27/56 (48.21%), Postives = 38/56 (67.86%), Query Frame = 1
Query: 511 VRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
VR ++ Y + DEL+ + GD +T T EDE +GW RGR +GQ G++P N+VEPI
Sbjct: 317 VRALYDYDGQEQDELSFKAGDELTKTEDEDE-QGWCRGRLDSGQEGLYPANYVEPI 371
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Match: SMESG000079662.1 (SMESG000079662.1) HSP 1 Score: 996.882 bits (2576), Expect = 0.000e+0 Identity = 513/513 (100.00%), Postives = 513/513 (100.00%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPANTVKDDGISFDAPVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTTPAIKLKPKESSISNFDRNVDHVTKLKSKDTILTEKPIESPIGKDKPKDTIIPTSTVAPVEKEPEVSPLKPTQNFKANTLPXXXXXXXXXXANIASLKNENDHKNDIMKLKSKISDLEEKNTDLHKELLELRKYSNEQTNMLKIKINKLTNELDEEKTKRAANEVNFSRLKEKVEDLEMSMQSLLHK 1611
MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPANTVKDDGISFDAPVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTTPAIKLKPKESSISNFDRNVDHVTKLKSKDTILTEKPIESPIGKDKPKDTIIPTSTVAPVEKEPEVSPLKPTQNFKANTLPKNVDVVKVDNANIASLKNENDHKNDIMKLKSKISDLEEKNTDLHKELLELRKYSNEQTNMLKIKINKLTNELDEEKTKRAANEVNFSRLKEKVEDLEMSMQSLLHK
Sbjct: 1 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKEDRRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAAIIKAGPPPPVTAAKPKINVGKSIPPRPPQLLEKQASKPANTVKDDGISFDAPVNHKPLVGPNAGRAKRPGKKLPSNINIVTGNTEKPNDDEDSTPVSRSNSNENILIIDTTPAIKLKPKESSISNFDRNVDHVTKLKSKDTILTEKPIESPIGKDKPKDTIIPTSTVAPVEKEPEVSPLKPTQNFKANTLPKNVDVVKVDNANIASLKNENDHKNDIMKLKSKISDLEEKNTDLHKELLELRKYSNEQTNMLKIKINKLTNELDEEKTKRAANEVNFSRLKEKVEDLEMSMQSLLHK 513
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Match: SMESG000001129.1 (SMESG000001129.1) HSP 1 Score: 130.954 bits (328), Expect = 5.203e-33 Identity = 85/205 (41.46%), Postives = 105/205 (51.22%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKED-RRKSQEDNLIIPQAEERNNNTKENDVVIEQTPPPKKVTGVGFGNIFSGGEIKLKTTNKDNKPKVISEEVKPEILQEKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKE 684
MD + E+DY A ADEL++ KGDII SV E GW G L GKEGVFP NF K +K D + S ++N P E+ N NTK KLKT + D K K E K I + +V I SY AEN DE+T+E+GDII V NK D+GWW+G K G+ G+FP NFV+P E
Sbjct: 1 MDCIAEYDYSATHADELSLKKGDIIKSVIFFETGWKKGWLNGKEGVFPDNFVKVIKTDFKNTSNKENGTNPNVED-NLNTK----------------------------TKLKTHSSDQKTKTTKE--KSHI------NNSLNEPLIVEAIFSYKAENPDEITIEVGDIIKVLNKNLIDDGWWKGIKRTGEIGIFPSNFVQPFSE 168
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Match: SMESG000001129.1 (SMESG000001129.1) HSP 1 Score: 74.7146 bits (182), Expect = 7.183e-16 Identity = 42/81 (51.85%), Postives = 51/81 (62.96%), Query Frame = 1
Query: 73 MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNFGKPVKED-RRKSQEDNLIIPQAEERNNNTK 312
MD + E+DY A ADEL++ KGDII SV E GW G L GKEGVFP NF K +K D + S ++N P E+ N NTK
Sbjct: 1 MDCIAEYDYSATHADELSLKKGDIIKSVIFFETGWKKGWLNGKEGVFPDNFVKVIKTDFKNTSNKENGTNPNVED-NLNTK 80 HSP 2 Score: 46.2098 bits (108), Expect = 7.018e-6 Identity = 29/67 (43.28%), Postives = 40/67 (59.70%), Query Frame = 1
Query: 523 HSYTAENSDELTLEIGDII-TVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKPSRPNNAA 720
+ Y+A ++DEL+L+ GDII +V E GW +G NG+ GVFPDNFV+ IK + S N
Sbjct: 7 YDYSATHADELSLKKGDIIKSVIFFE---TGWKKGW-LNGKEGVFPDNFVKVIKTDFKNTSNKENGT 69
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Match: SMESG000073128.1 (SMESG000073128.1) HSP 1 Score: 57.3806 bits (137), Expect = 3.197e-8 Identity = 28/69 (40.58%), Postives = 44/69 (63.77%), Query Frame = 1
Query: 472 EKKPKETTRTKDVVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPI 678
E + +T +TK + + Y ++SDE+ E+G+IIT + E+ DEGWW G +G+ G+FP N+VE I
Sbjct: 547 ENQDTKTPKTKSA-KAVFEYECQDSDEIDFEVGEIIT--DIEEIDEGWWIGCNKSGKRGMFPSNYVELI 612 HSP 2 Score: 50.0618 bits (118), Expect = 5.700e-6 Identity = 22/54 (40.74%), Postives = 32/54 (59.26%), Query Frame = 1
Query: 508 VVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFV 669
V ++SY A DE++ E G+ I N+ DE GWW+G +G G+FP N+V
Sbjct: 644 TVVAVYSYHALQDDEISFEEGEHIYNVNQIDE--GWWQGETKDGDKGMFPSNYV 695
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Match: SMESG000004952.1 (SMESG000004952.1) HSP 1 Score: 52.373 bits (124), Expect = 2.132e-7 Identity = 24/64 (37.50%), Postives = 40/64 (62.50%), Query Frame = 1
Query: 508 VVRVIHSYTAENSDELTLEIGDIITVTNKEDEDEGWWRGRKSNGQSGVFPDNFVEPIKEENNKP 699
VVR I+SY A+++DEL+ E GD++ + + + WW+ R +NG+ G+ P N+V E + P
Sbjct: 16 VVRAIYSYEAQSADELSFEEGDLLYIFDMISSQD-WWKAR-ANGKEGLIPSNYVSKQTESIDNP 77 The following BLAST results are available for this feature:
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of SH3 domain-containing kinase-binding protein 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020355 ID=SMED30020355|Name=SH3 domain-containing kinase-binding protein 1|organism=Schmidtea mediterranea sexual|type=transcript|length=2068bpback to top protein sequence of SMED30020355-orf-1 >SMED30020355-orf-1 ID=SMED30020355-orf-1|Name=SMED30020355-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=514bp MDYLIEFDYDADEADELTIHKGDIINSVRPHEDGWMYGILRGKEGVFPSNback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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