Heat shock protein 90

Overview
NameHeat shock protein 90
Smed IDSMED30020317
Length (bp)2308
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Heat shock protein 90 (SMED30020317) t-SNE clustered cells

Violin plots show distribution of expression levels for Heat shock protein 90 (SMED30020317) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Heat shock protein 90 (SMED30020317) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Heat shock protein 90 (SMED30020317) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30020317

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 19

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30020317SMESG000024822.1 Contig1490GPL15192PMID:23079596
Forsthoefel et al., 2012
whole organism asexual adult colorimetric in situ hybridization evidence
dorsal ventral margin of the whole animalSMED30020317SMESG000024822.1 Contig1490GPL15192PMID:23079596
Forsthoefel et al., 2012
whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30020317SMESG000024822.1 Contig1490GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30020317SMESG000024822.1 dd_Smed_v4_678_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020317SMESG000024822.1 Contig49305newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020317SMESG000024822.1 Contig49305uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
head regionSMED30020317SMESG000024822.1 dd_Smed_v6_678_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
neuronSMED30020317SMESG000024822.1 Contig49305newmark_estsPMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
neuronSMED30020317SMESG000024822.1 Contig49305uc_Smed_v2PMID:27612384
Roberts-Galbraith et al., 2016
whole organism asexual adult colorimetric in situ hybridization evidence
Category 2 cellSMED30020317SMESG000024822.1 dd_Smed_v6_678_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 3 cellSMED30020317SMESG000024822.1 dd_Smed_v6_678_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
progenitor cellSMED30020317SMESG000024822.1 dd_Smed_v6_678_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30020317SMESG000024822.1 dd_Smed_v6_678_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Heat shock protein 90 vs. Ensembl Human
Match: HSP90AA1 (heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253])

HSP 1 Score: 679.863 bits (1753), Expect = 0.000e+0
Identity = 350/445 (78.65%), Postives = 400/445 (89.89%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG---DVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFEN+KK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY +RMKENQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+K  FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHS+++ L+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LEDPQ HANRI+RMIKLGLGIDEDD   D T      ++P  P   +D+  +MEEVD
Sbjct:  290 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMP--PLEGDDDTSRMEEVD 732          

HSP 2 Score: 349.362 bits (895), Expect = 1.092e-108
Identity = 178/214 (83.18%), Postives = 198/214 (92.52%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP+K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ DT EP+GRG+K+IL +KEDQ EYLEER+IKEI+KKHSQFIGYPI L +EKERDKEVS
Sbjct:   18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVS 231          
BLAST of Heat shock protein 90 vs. Ensembl Human
Match: HSP90AA1 (heat shock protein 90 alpha family class A member 1 [Source:HGNC Symbol;Acc:HGNC:5253])

HSP 1 Score: 677.552 bits (1747), Expect = 0.000e+0
Identity = 350/445 (78.65%), Postives = 400/445 (89.89%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG---DVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFEN+KK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY +RMKENQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+K  FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHS+++ L+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LEDPQ HANRI+RMIKLGLGIDEDD   D T      ++P  P   +D+  +MEEVD
Sbjct:  412 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTSAAVTEEMP--PLEGDDDTSRMEEVD 854          

HSP 2 Score: 347.821 bits (891), Expect = 6.926e-107
Identity = 178/214 (83.18%), Postives = 198/214 (92.52%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP+K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ DT EP+GRG+K+IL +KEDQ EYLEER+IKEI+KKHSQFIGYPI L +EKERDKEVS
Sbjct:  140 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVS 353          
BLAST of Heat shock protein 90 vs. Ensembl Human
Match: HSP90AB1 (heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol;Acc:HGNC:5258])

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 344/444 (77.48%), Postives = 400/444 (90.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+C++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KNLKLGIHEDS NR +L++ LRYH++ SG+EMTSL +Y+SRMKE QK IYYITGESK+ VA+SAFVER+ KRGFEV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LEDPQ H+NRI+RMIKLGLGIDED++  +      VP  + P   +++A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAA-VPDEIPPLEGDEDASRMEEVD 724          

HSP 2 Score: 339.732 bits (870), Expect = 4.198e-105
Identity = 171/213 (80.28%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL I IIP+    TLT++DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ D  EP+GRG+K+IL +KEDQ EYLEER++KE++KKHSQFIGYPI L LEKER+KE+S
Sbjct:   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEIS 226          
BLAST of Heat shock protein 90 vs. Ensembl Human
Match: HSP90AB1 (heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol;Acc:HGNC:5258])

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 344/444 (77.48%), Postives = 400/444 (90.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+C++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KNLKLGIHEDS NR +L++ LRYH++ SG+EMTSL +Y+SRMKE QK IYYITGESK+ VA+SAFVER+ KRGFEV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LEDPQ H+NRI+RMIKLGLGIDED++  +      VP  + P   +++A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAA-VPDEIPPLEGDEDASRMEEVD 724          

HSP 2 Score: 339.732 bits (870), Expect = 4.198e-105
Identity = 171/213 (80.28%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL I IIP+    TLT++DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ D  EP+GRG+K+IL +KEDQ EYLEER++KE++KKHSQFIGYPI L LEKER+KE+S
Sbjct:   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEIS 226          
BLAST of Heat shock protein 90 vs. Ensembl Human
Match: HSP90AB1 (heat shock protein 90 alpha family class B member 1 [Source:HGNC Symbol;Acc:HGNC:5258])

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 344/444 (77.48%), Postives = 400/444 (90.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+C++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KNLKLGIHEDS NR +L++ LRYH++ SG+EMTSL +Y+SRMKE QK IYYITGESK+ VA+SAFVER+ KRGFEV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LEDPQ H+NRI+RMIKLGLGIDED++  +      VP  + P   +++A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVAAEEPNAA-VPDEIPPLEGDEDASRMEEVD 724          

HSP 2 Score: 339.732 bits (870), Expect = 4.198e-105
Identity = 171/213 (80.28%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL I IIP+    TLT++DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ D  EP+GRG+K+IL +KEDQ EYLEER++KE++KKHSQFIGYPI L LEKER+KE+S
Sbjct:   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEIS 226          
BLAST of Heat shock protein 90 vs. Ensembl Celegans
Match: hsp-90 (Heat shock protein 90 [Source:UniProtKB/Swiss-Prot;Acc:Q18688])

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 352/455 (77.36%), Postives = 396/455 (87.03%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGD-------VPVGPSA------TEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+YAEFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKK +N+IKLYVRRVFIM+NCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKC+EL +E+ EDKDN+KKFYEQF KNLKLGIHEDS NR KL+DFLRY STS+G+E TSLK+Y+SRMKENQ  IYYITGESKD VA SAFVER+  RGFEVLYM DPIDEY VQQLKEYDGKKLV VTKEGLELPE EEEKKKFEE K A+E LCKV+KDIL+KKVEKV VSNRLVSSPCCIVTS++GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDH++MK L+ RV+ DKNDK+VKDLV+LL+ET+LL+SGF+LE+PQ HA+RI+RMIKLGL             +GD       VP   +A       E++A +MEEVD
Sbjct:  261 LNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRY-STSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLD------------IGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD 702          

HSP 2 Score: 312.768 bits (800), Expect = 1.483e-95
Identity = 158/205 (77.07%), Postives = 186/205 (90.73%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            ++ETFAFQAEIAQL+SLIINTFYSNKEI+LRELISN+SDALDKIRY++LT+PS LDT KEL IKI P+K+  TLTI+DTGIGMTK+DL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS++LVADKV V SK NDD+ Y WESSAGGSF ++P     + RG+KI++ +KEDQ+++LEERKIKEI+KKHSQFIGYPIKL
Sbjct:    4 NAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKL 208          
BLAST of Heat shock protein 90 vs. Ensembl Celegans
Match: hsp-90 (Heat shock protein 90 [Source:UniProtKB/Swiss-Prot;Acc:Q18688])

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 352/455 (77.36%), Postives = 396/455 (87.03%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGD-------VPVGPSA------TEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+YAEFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKK +N+IKLYVRRVFIM+NCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKC+EL +E+ EDKDN+KKFYEQF KNLKLGIHEDS NR KL+DFLRY STS+G+E TSLK+Y+SRMKENQ  IYYITGESKD VA SAFVER+  RGFEVLYM DPIDEY VQQLKEYDGKKLV VTKEGLELPE EEEKKKFEE K A+E LCKV+KDIL+KKVEKV VSNRLVSSPCCIVTS++GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDH++MK L+ RV+ DKNDK+VKDLV+LL+ET+LL+SGF+LE+PQ HA+RI+RMIKLGL             +GD       VP   +A       E++A +MEEVD
Sbjct:  261 LNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRY-STSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLD------------IGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD 702          

HSP 2 Score: 312.768 bits (800), Expect = 1.483e-95
Identity = 158/205 (77.07%), Postives = 186/205 (90.73%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            ++ETFAFQAEIAQL+SLIINTFYSNKEI+LRELISN+SDALDKIRY++LT+PS LDT KEL IKI P+K+  TLTI+DTGIGMTK+DL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS++LVADKV V SK NDD+ Y WESSAGGSF ++P     + RG+KI++ +KEDQ+++LEERKIKEI+KKHSQFIGYPIKL
Sbjct:    4 NAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKL 208          
BLAST of Heat shock protein 90 vs. Ensembl Celegans
Match: hsp-90 (Heat shock protein 90 [Source:UniProtKB/Swiss-Prot;Acc:Q18688])

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 352/455 (77.36%), Postives = 396/455 (87.03%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGD-------VPVGPSA------TEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+YAEFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKK +N+IKLYVRRVFIM+NCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKC+EL +E+ EDKDN+KKFYEQF KNLKLGIHEDS NR KL+DFLRY STS+G+E TSLK+Y+SRMKENQ  IYYITGESKD VA SAFVER+  RGFEVLYM DPIDEY VQQLKEYDGKKLV VTKEGLELPE EEEKKKFEE K A+E LCKV+KDIL+KKVEKV VSNRLVSSPCCIVTS++GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDH++MK L+ RV+ DKNDK+VKDLV+LL+ET+LL+SGF+LE+PQ HA+RI+RMIKLGL             +GD       VP   +A       E++A +MEEVD
Sbjct:  261 LNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRY-STSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLD------------IGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD 702          

HSP 2 Score: 312.768 bits (800), Expect = 1.483e-95
Identity = 158/205 (77.07%), Postives = 186/205 (90.73%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            ++ETFAFQAEIAQL+SLIINTFYSNKEI+LRELISN+SDALDKIRY++LT+PS LDT KEL IKI P+K+  TLTI+DTGIGMTK+DL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS++LVADKV V SK NDD+ Y WESSAGGSF ++P     + RG+KI++ +KEDQ+++LEERKIKEI+KKHSQFIGYPIKL
Sbjct:    4 NAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKL 208          
BLAST of Heat shock protein 90 vs. Ensembl Celegans
Match: hsp-90 (Heat shock protein 90 [Source:UniProtKB/Swiss-Prot;Acc:Q18688])

HSP 1 Score: 675.241 bits (1741), Expect = 0.000e+0
Identity = 352/455 (77.36%), Postives = 396/455 (87.03%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGD-------VPVGPSA------TEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+YAEFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKK +N+IKLYVRRVFIM+NCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKC+EL +E+ EDKDN+KKFYEQF KNLKLGIHEDS NR KL+DFLRY STS+G+E TSLK+Y+SRMKENQ  IYYITGESKD VA SAFVER+  RGFEVLYM DPIDEY VQQLKEYDGKKLV VTKEGLELPE EEEKKKFEE K A+E LCKV+KDIL+KKVEKV VSNRLVSSPCCIVTS++GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDH++MK L+ RV+ DKNDK+VKDLV+LL+ET+LL+SGF+LE+PQ HA+RI+RMIKLGL             +GD       VP   +A       E++A +MEEVD
Sbjct:  261 LNKTKPIWTRNPDDISNEEYAEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPQRAPFDLFENKKSKNSIKLYVRRVFIMENCEELMPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCMELIDEVAEDKDNFKKFYEQFGKNLKLGIHEDSTNRKKLSDFLRY-STSAGDEPTSLKEYVSRMKENQTQIYYITGESKDVVAASAFVERVKSRGFEVLYMCDPIDEYCVQQLKEYDGKKLVSVTKEGLELPETEEEKKKFEEDKVAYENLCKVIKDILEKKVEKVGVSNRLVSSPCCIVTSEYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHAIMKTLRDRVEVDKNDKTVKDLVVLLFETALLASGFSLEEPQSHASRIYRMIKLGLD------------IGDDEIEDSAVPSSCTAEAKIEGAEEDASRMEEVD 702          

HSP 2 Score: 312.768 bits (800), Expect = 1.483e-95
Identity = 158/205 (77.07%), Postives = 186/205 (90.73%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            ++ETFAFQAEIAQL+SLIINTFYSNKEI+LRELISN+SDALDKIRY++LT+PS LDT KEL IKI P+K+  TLTI+DTGIGMTK+DL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS++LVADKV V SK NDD+ Y WESSAGGSF ++P     + RG+KI++ +KEDQ+++LEERKIKEI+KKHSQFIGYPIKL
Sbjct:    4 NAETFAFQAEIAQLMSLIINTFYSNKEIYLRELISNASDALDKIRYQALTEPSELDTGKELFIKITPNKEEKTLTIMDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAFLVADKVVVTSKNNDDDSYQWESSAGGSFVVRPFNDPEVTRGTKIVMHIKEDQIDFLEERKIKEIVKKHSQFIGYPIKL 208          
BLAST of Heat shock protein 90 vs. Ensembl Celegans
Match: enpl-1 (Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;Acc:Q22235])

HSP 1 Score: 335.88 bits (860), Expect = 1.729e-104
Identity = 186/412 (45.15%), Postives = 275/412 (66.75%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKR-NNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDI-LDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQAL---RDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            +N  KPIW R P+ V +++Y +FYKS+T D E+ L+  HFS EG++ FR++L+ PK++P D+F+N  K   NIKLYVRRVFI D+  D++P+YL+F++G+VDS+DLPLN+SRE LQQ+K+LKVI+K LV+K L++ +++  D   +  F+ +F+ N+KLG+ ED  NR +LA  LR+ S++  ++ T+L  Y+ RMKE Q  IYY+ G S+  V  S FVERL  +G+EVL++ + +DEY +Q + EY+ KK   V KEG+ + + E+ K+  +  +  F+PL   +K+  L   +EK  VS RLV SP  +V S +GWS NMERIMK+QA    +D +   Y   KK  EINP H V+K L  RV A + D +      LL+ET+ L SGF+L+D    A+RI  +++  L
Sbjct:  243 VNNVKPIWMRKPNQVEEDEYKQFYKSITKDSEEPLSHVHFSAEGEVSFRSILYVPKKSPNDMFQNYGKVIENIKLYVRRVFITDDFADMLPKYLSFIRGIVDSDDLPLNVSRENLQQHKLLKVIKKKLVRKVLDMLKKL--DGAQFDDFWSEFSTNIKLGVMEDPSNRMRLAKLLRFQSSNDADKTTTLAAYVERMKEKQDAIYYMAGTSRKEVETSPFVERLIAKGYEVLFLTEAVDEYCIQAMPEYESKKFQNVAKEGVTIDDGEKAKEAHKGLEEEFKPLTDWLKETALKDLIEKAVVSQRLVKSPSALVASSYGWSGNMERIMKSQAYAKAKDPTQDFYATQKKTFEINPRHPVIKELLKRVTASEEDTTAASTAKLLFETATLRSGFSLQDQVGFADRIEAVLRQSL 652          

HSP 2 Score: 196.823 bits (499), Expect = 2.563e-53
Identity = 107/198 (54.04%), Postives = 140/198 (70.71%), Query Frame = 3
Query:   90 LLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADIS-----MIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDT-SEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            ++ LIIN+ Y NKEIFLRELISN+SDALDKIR  SLTDP  L   +E+ +KI  D++   L I DTG+GMT+ DLINNLGTIARSGT  F+  L   A  S     +IGQFGVGFY+++LVAD+V V +K NDD+QY+WES +  SFTI  D     L RG++I L++KE+  ++LE   +K ++ K+SQFI + I L
Sbjct:    1 MMKLIINSLYRNKEIFLRELISNASDALDKIRLLSLTDPEQLRETEEMSVKIKADRENRLLHITDTGVGMTRQDLINNLGTIARSGTSEFLSKLMDTATSSDQQQDLIGQFGVGFYAAFLVADRVVVTTKNNDDDQYIWESDS-ASFTISKDPRGNTLKRGTQITLYLKEEAADFLEPDTLKNLVHKYSQFINFDIFL 197          
BLAST of Heat shock protein 90 vs. Ensembl Fly
Match: Hsp83 (gene:FBgn0001233 transcript:FBtr0332873)

HSP 1 Score: 987.638 bits (2552), Expect = 0.000e+0
Identity = 542/715 (75.80%), Postives = 620/715 (86.71%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXX--XXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL IK+IP+K AGTLTIIDTGIGMTKSDL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVADKV V SK NDDEQY+WESSAGGSFT++ D SEPLGRG+KI+L++KEDQ +YLEE KIKEI+ KHSQFIGYPIKL++    EKE   + +DDE +   +K+E E  E K +    D++ D   KD KKKK IKEKY ++EELNKTKPIWTRNPDD+SQE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+R PFDLFEN+KKRNNIKLYVRRVFIMDNCEDLIPEYLNF+KGVVDSEDLPLNISREMLQQNK+LKVIRKNLVKK +EL EE+ EDK+NYKKFY+QF+KNLKLG+HEDS NR KLADFLR+H+++SG++  SL DY+SRMK+NQK +Y+ITGESKD V++SAFVER+  RGFEV+YM +PIDEY +Q LKEY GK+LV VTKEGLELPEDE EKKK EE KA FE LCK+MK ILD KVEKV VSNRLV SPCCIVTSQFGWSANMERIMKAQALRD++TMGYMA KK LEINPDH +++ L+ + DADKNDK+VKDLV+LL+ETSLLSSGF+L+ PQ+HA+RI+RMIKLGLGIDED+          GD P     TED A  MEEVD
Sbjct:    4 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSLVEDTED-ASHMEEVD 717          
BLAST of Heat shock protein 90 vs. Ensembl Fly
Match: Hsp83 (gene:FBgn0001233 transcript:FBtr0073040)

HSP 1 Score: 987.638 bits (2552), Expect = 0.000e+0
Identity = 542/715 (75.80%), Postives = 620/715 (86.71%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXX--XXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL IK+IP+K AGTLTIIDTGIGMTKSDL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVADKV V SK NDDEQY+WESSAGGSFT++ D SEPLGRG+KI+L++KEDQ +YLEE KIKEI+ KHSQFIGYPIKL++    EKE   + +DDE +   +K+E E  E K +    D++ D   KD KKKK IKEKY ++EELNKTKPIWTRNPDD+SQE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+R PFDLFEN+KKRNNIKLYVRRVFIMDNCEDLIPEYLNF+KGVVDSEDLPLNISREMLQQNK+LKVIRKNLVKK +EL EE+ EDK+NYKKFY+QF+KNLKLG+HEDS NR KLADFLR+H+++SG++  SL DY+SRMK+NQK +Y+ITGESKD V++SAFVER+  RGFEV+YM +PIDEY +Q LKEY GK+LV VTKEGLELPEDE EKKK EE KA FE LCK+MK ILD KVEKV VSNRLV SPCCIVTSQFGWSANMERIMKAQALRD++TMGYMA KK LEINPDH +++ L+ + DADKNDK+VKDLV+LL+ETSLLSSGF+L+ PQ+HA+RI+RMIKLGLGIDED+          GD P     TED A  MEEVD
Sbjct:    4 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSLVEDTED-ASHMEEVD 717          
BLAST of Heat shock protein 90 vs. Ensembl Fly
Match: Gp93 (gene:FBgn0039562 transcript:FBtr0085254)

HSP 1 Score: 340.887 bits (873), Expect = 3.999e-105
Identity = 193/413 (46.73%), Postives = 282/413 (68.28%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFEN-KKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDI-LDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALR---DSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG 2075
            +N +KPIWTR P +V++++Y  FYKSLT D  + L   HF  EG++ F++LL+ PK  P + F     K +NIKLYVRRVFI D   D++P YL+F++GVVDS+DLPLN+SRE LQQ+K++KVI+K LV+K L++ ++I  DK+ Y+KF+++F+ N+KLG+ ED  NR++LA  LR+  TS+G+ +TSL +Y  RMK  Q+ IYYI G ++  V  S FVERL  +G+EVLY+++ +DEY +  L E+DGKK   V KEG +L E E+ KK FE  K+ FEPL K + D+ L  ++ K  VS RL +SPC +V   FGW+ NMER+  + A +   D     Y+  KK LEINP H +M+ L  RV+AD+ D + KD+ ++++ T+ L SG+ L++    A+ I +M++  LG
Sbjct:  336 INDSKPIWTRKPAEVTEDEYTSFYKSLTKDSSEPLTQTHFIAEGEVTFKSLLYVPKVQPSESFNRYGTKSDNIKLYVRRVFITDEFNDMMPNYLSFIRGVVDSDDLPLNVSRETLQQHKLIKVIKKKLVRKVLDMLKKI--DKEAYEKFWKEFSTNIKLGVMEDPSNRSRLAKLLRFQ-TSNGKGVTSLAEYKERMKAKQEHIYYIAGANRAEVEKSPFVERLLSKGYEVLYLVEAVDEYCISALPEFDGKKFQNVAKEGFQLNESEKSKKNFESLKSTFEPLVKWLNDVALKDQISKAQVSERLSNSPCALVAGVFGWTGNMERLAMSNAHQKSDDPQRTYYLNQKKTLEINPRHPLMRELLRRVEADEADDTAKDMAVMMFRTATLRSGYMLQETSQFADSIEQMMRQTLG 745          

HSP 2 Score: 205.297 bits (521), Expect = 1.219e-55
Identity = 115/218 (52.75%), Postives = 158/218 (72.48%), Query Frame = 3
Query:   33 LMESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQ-----AGADIS-MIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDT-SEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            L E    ++ F FQ E+ +++ LIIN+ Y NKEIFLRELISN+SDA+DKIR  +L++   L+T  EL I+I  DK+   L I+D+GIGMT  DLINNLGTIA+SGT  F+  +Q      G D++ MIGQFGVGFYS++LVAD+V V +K NDD+QY+WES A  SF+I  D   + L RGS I L++KE+  ++LEE  ++E+I+K+SQFI +PI++
Sbjct:   65 LKEIREKAKKFTFQTEVNRMMKLIINSLYRNKEIFLRELISNASDAIDKIRLLALSNSKELETNPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTADFLAKMQDPSKSEGLDMNDMIGQFGVGFYSAFLVADRVVVTTKHNDDKQYIWESDA-NSFSITEDPRGDTLKRGSVISLYLKEEAQDFLEEDTVRELIRKYSQFINFPIRM 281          
BLAST of Heat shock protein 90 vs. Ensembl Fly
Match: Trap1 (gene:FBgn0026761 transcript:FBtr0086149)

HSP 1 Score: 176.407 bits (446), Expect = 3.575e-46
Identity = 123/421 (29.22%), Postives = 217/421 (51.54%), Query Frame = 3
Query:  855 NKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNN-IKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDK-DNYKKFYEQFAKNLKLGI--HEDSVNRNKLADFLRYHS----TSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXX---XXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVML----LYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            N+ KP+W   P  +S+E + +FY+ ++N ++      H++ +  L   ALL+ P+  P  LFE  +  N  + LY R+V I    E L+P++L FVKGVVDSED+PLN+SRE+LQ + +++ +   +  + +   +E  + + + Y+ FY  +   LK GI    D+  + ++A  LR+ S    T+SG    SL++Y + +   Q++IYY+   ++     S + E L KR   VL+  +P DE  + QL ++  KKLV V KE  E  ++        +    ++  + L   +++ L  +V KV  + RL + PC I   +    A     ++ Q+ +      +   +  LEINP H ++K L    ++D      KDL  L    L+  +++ +G A EDP++    ++ ++   L
Sbjct:  281 NEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETASGR--MSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKEMREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEM---AAARHFIRTQSHQVPEQNRFALLQPELEINPKHPIIKKLNKLRESD------KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTLLSRAL 688          

HSP 2 Score: 155.992 bits (393), Expect = 2.427e-39
Identity = 97/212 (45.75%), Postives = 138/212 (65.09%), Query Frame = 3
Query:   69 FQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLT--DPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEAL---QAG----ADISMIGQFGVGFYSSYLVADKVQVISKGN--DDEQYLWESSAGGSFTIK--PDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            FQAE  QLL ++  + YS+ E+F+RELISN+SDAL+K RY SL+    ++    + L I+I  DK    L I DTGIGMTK +L++NLGTIARSG+K F+E +   Q G    A  ++IGQFGVGFYSS++VA+KV+V ++    +     W +   G++ I+  PD       G++I+L +K D  EY +E +IK +IKK+S F+G PI L
Sbjct:   68 FQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVE----LGTRIVLHLKTDCREYADEERIKAVIKKYSNFVGSPILL 275          
BLAST of Heat shock protein 90 vs. Ensembl Fly
Match: Trap1 (gene:FBgn0026761 transcript:FBtr0336666)

HSP 1 Score: 176.407 bits (446), Expect = 3.575e-46
Identity = 123/421 (29.22%), Postives = 217/421 (51.54%), Query Frame = 3
Query:  855 NKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNN-IKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDK-DNYKKFYEQFAKNLKLGI--HEDSVNRNKLADFLRYHS----TSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXX---XXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVML----LYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            N+ KP+W   P  +S+E + +FY+ ++N ++      H++ +  L   ALL+ P+  P  LFE  +  N  + LY R+V I    E L+P++L FVKGVVDSED+PLN+SRE+LQ + +++ +   +  + +   +E  + + + Y+ FY  +   LK GI    D+  + ++A  LR+ S    T+SG    SL++Y + +   Q++IYY+   ++     S + E L KR   VL+  +P DE  + QL ++  KKLV V KE  E  ++        +    ++  + L   +++ L  +V KV  + RL + PC I   +    A     ++ Q+ +      +   +  LEINP H ++K L    ++D      KDL  L    L+  +++ +G A EDP++    ++ ++   L
Sbjct:  281 NEIKPLWLLEPQSISKEQHHDFYRFISNSFDVPRFTLHYNADVPLSIHALLYFPEGKP-GLFEMSRDGNTGVALYTRKVLIQSKTEHLLPKWLRFVKGVVDSEDIPLNLSRELLQNSSLIRKLSSVISTRVIRFLQERSKKQPEEYEAFYRDYGLFLKEGIVTSSDASEKEEIAKLLRFESSKSETASGR--MSLEEYYNAVPAEQQNIYYLAAPNRVLAESSPYYESLKKRNELVLFCYEPYDELVLMQLGKFKSKKLVSVEKEMREESKETTATTDFGEGSLLRSELDTLIPWLEEELRGQVIKVKATTRLDTHPCVITVEEM---AAARHFIRTQSHQVPEQNRFALLQPELEINPKHPIIKKLNKLRESD------KDLAQLIAKQLFANAMVGAGLA-EDPRMLLTNMNTLLSRAL 688          

HSP 2 Score: 155.992 bits (393), Expect = 2.427e-39
Identity = 97/212 (45.75%), Postives = 138/212 (65.09%), Query Frame = 3
Query:   69 FQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLT--DPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEAL---QAG----ADISMIGQFGVGFYSSYLVADKVQVISKGN--DDEQYLWESSAGGSFTIK--PDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            FQAE  QLL ++  + YS+ E+F+RELISN+SDAL+K RY SL+    ++    + L I+I  DK    L I DTGIGMTK +L++NLGTIARSG+K F+E +   Q G    A  ++IGQFGVGFYSS++VA+KV+V ++    +     W +   G++ I+  PD       G++I+L +K D  EY +E +IK +IKK+S F+G PI L
Sbjct:   68 FQAETRQLLDIVARSLYSDHEVFVRELISNASDALEKFRYTSLSAGGENLAGKDRPLEIRITTDKPLMQLIIQDTGIGMTKEELVSNLGTIARSGSKKFLEQMKGTQQGASSEASSNIIGQFGVGFYSSFIVANKVEVFTRAAVPNAPGLRWSTDGSGTYEIEEVPDVE----LGTRIVLHLKTDCREYADEERIKAVIKKYSNFVGSPILL 275          
BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Match: hsp90aa1.1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 [Source:NCBI gene;Acc:30591])

HSP 1 Score: 669.463 bits (1726), Expect = 0.000e+0
Identity = 344/445 (77.30%), Postives = 393/445 (88.31%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNCE+LIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCL+LF E+ EDKDNYKK+YEQF+KN+KLGIHEDS NR KL+D LRY++++SG+EM SLKDY+SRMK+ QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKEYDGK LV VTKEGLELPEDEEEKKK +E KA +E LCK+MKDILDKK+EKVTVSNRLVSSPCCIVTS +GW+ANMERIMK+QALRD+STMGYM AKKHLEINP H +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF L+DPQ HANRI+RMIKLGLGI   D    EI      D+PV     +D+  +MEEVD
Sbjct:  283 LNKTKPIWTRNPDDITNEEYGEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLDLFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSDLLRYYTSASGDEMVSLKDYVSRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLVSVTKEGLELPEDEEEKKKQDELKAKYENLCKIMKDILDKKIEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPAHPIVETLREKAEADKNDKAVKDLVILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGIDDDDSVVEEISQPAEEDMPVLEG--DDDTSRMEEVD 725          

HSP 2 Score: 341.273 bits (874), Expect = 8.804e-106
Identity = 171/213 (80.28%), Postives = 198/213 (92.96%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ K+L I++IPD+   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY+WES+AGGSFT+KPD  E +GRG+K+IL +KEDQ EY+EE++IKE++KKHSQFIGYPI L +EK+R+KEV
Sbjct:   15 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKDLKIELIPDQKERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPDFGESIGRGTKVILHLKEDQSEYVEEKRIKEVVKKHSQFIGYPITLYIEKQREKEV 227          
BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Match: hsp90aa1.1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1 [Source:NCBI gene;Acc:30591])

HSP 1 Score: 669.463 bits (1726), Expect = 0.000e+0
Identity = 344/445 (77.30%), Postives = 393/445 (88.31%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSL+NDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNCE+LIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCL+LF E+ EDKDNYKK+YEQF+KN+KLGIHEDS NR KL+D LRY++++SG+EM SLKDY+SRMK+ QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKEYDGK LV VTKEGLELPEDEEEKKK +E KA +E LCK+MKDILDKK+EKVTVSNRLVSSPCCIVTS +GW+ANMERIMK+QALRD+STMGYM AKKHLEINP H +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF L+DPQ HANRI+RMIKLGLGI   D    EI      D+PV     +D+  +MEEVD
Sbjct:  283 LNKTKPIWTRNPDDITNEEYGEFYKSLSNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLDLFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSDLLRYYTSASGDEMVSLKDYVSRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLVSVTKEGLELPEDEEEKKKQDELKAKYENLCKIMKDILDKKIEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPAHPIVETLREKAEADKNDKAVKDLVILLFETALLSSGFTLDDPQTHANRIYRMIKLGLGIDDDDSVVEEISQPAEEDMPVLEG--DDDTSRMEEVD 725          

HSP 2 Score: 341.273 bits (874), Expect = 8.804e-106
Identity = 171/213 (80.28%), Postives = 198/213 (92.96%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ K+L I++IPD+   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY+WES+AGGSFT+KPD  E +GRG+K+IL +KEDQ EY+EE++IKE++KKHSQFIGYPI L +EK+R+KEV
Sbjct:   15 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKDLKIELIPDQKERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPDFGESIGRGTKVILHLKEDQSEYVEEKRIKEVVKKHSQFIGYPITLYIEKQREKEV 227          
BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Match: hsp90ab1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0
Identity = 350/447 (78.30%), Postives = 396/447 (88.59%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXX-----XXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDKDNYKKFY+ F+KNLKLGIHEDS NR KL++ LRY S+ SG+EMTSL +Y+SRMKENQK IYYITGESKD VAHSAFVER+ KRGFEVLYM +PIDEY VQQLK++DGK LV VTKEGLELPEDE+EKKK EE KA FE LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +M+ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGIDE      +         D+P  P   +D+A +MEEVD
Sbjct:  281 LNKTKPIWTRNPDDISNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFAELAEDKDNYKKFYDAFSKNLKLGIHEDSQNRKKLSELLRYQSSQSGDEMTSLTEYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYCVQQLKDFDGKSLVSVTKEGLELPEDEDEKKKMEEDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPSSAAAPEDIP--PLEGDDDASRMEEVD 725          

HSP 2 Score: 336.65 bits (862), Expect = 3.621e-104
Identity = 168/213 (78.87%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLREL+SN+SDALDKIRY+SLTDP+ LD+ K+L I IIP+    TLT+IDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D  EP+GRG+K+IL +KEDQ EY+EE+++KE++KKHSQFIGYPI L +EKERDKE+S
Sbjct:   13 TFAFQAEIAQLMSLIINTFYSNKEIFLRELVSNASDALDKIRYESLTDPTKLDSGKDLKIDIIPNVQERTLTLIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVKVDHGEPIGRGTKVILHLKEDQTEYIEEKRVKEVVKKHSQFIGYPITLYVEKERDKEIS 225          
BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Match: hsp90ab1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 663.3 bits (1710), Expect = 0.000e+0
Identity = 350/447 (78.30%), Postives = 396/447 (88.59%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXX-----XXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+S E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDKDNYKKFY+ F+KNLKLGIHEDS NR KL++ LRY S+ SG+EMTSL +Y+SRMKENQK IYYITGESKD VAHSAFVER+ KRGFEVLYM +PIDEY VQQLK++DGK LV VTKEGLELPEDE+EKKK EE KA FE LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +M+ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGIDE      +         D+P  P   +D+A +MEEVD
Sbjct:  281 LNKTKPIWTRNPDDISNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFAELAEDKDNYKKFYDAFSKNLKLGIHEDSQNRKKLSELLRYQSSQSGDEMTSLTEYVSRMKENQKSIYYITGESKDQVAHSAFVERVCKRGFEVLYMTEPIDEYCVQQLKDFDGKSLVSVTKEGLELPEDEDEKKKMEEDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDEDVPVEEPSSAAAPEDIP--PLEGDDDASRMEEVD 725          

HSP 2 Score: 336.65 bits (862), Expect = 3.621e-104
Identity = 168/213 (78.87%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLREL+SN+SDALDKIRY+SLTDP+ LD+ K+L I IIP+    TLT+IDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D  EP+GRG+K+IL +KEDQ EY+EE+++KE++KKHSQFIGYPI L +EKERDKE+S
Sbjct:   13 TFAFQAEIAQLMSLIINTFYSNKEIFLRELVSNASDALDKIRYESLTDPTKLDSGKDLKIDIIPNVQERTLTLIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVKVDHGEPIGRGTKVILHLKEDQTEYIEEKRVKEVVKKHSQFIGYPITLYVEKERDKEIS 225          
BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Match: hsp90aa1.2 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 652.899 bits (1683), Expect = 0.000e+0
Identity = 343/443 (77.43%), Postives = 399/443 (90.07%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDV-PVGPSATEDEAGKMEEVD 2177
            LNKTKP+WTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNC++LIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKK+YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY++RMK+ QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+K+ FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +++ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF L+DPQ H+NRI+RMIKLGLGIDEDD+  +      +  + P   +D+  +MEEVD
Sbjct:  292 LNKTKPLWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCDELIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKDNYKKYYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVTRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEFEGKNLVSVTKEGLELPEDEEEKKKQEEKKSKFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIVETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGIDEDDLSAEEPSSAPIEEMPPLEGDDDTSRMEEVD 734          

HSP 2 Score: 345.125 bits (884), Expect = 2.868e-107
Identity = 178/214 (83.18%), Postives = 199/214 (92.99%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ K+L I+IIP+K+  TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K  DDEQY WESSAGGSFT+K D SEP+GRG+K+IL +KEDQ EY+EER+IKEI+KKHSQFIGYPI L +EKERDKEVS
Sbjct:   16 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKDLKIEIIPNKEERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHLDDEQYAWESSAGGSFTVKVDNSEPIGRGTKVILHLKEDQTEYIEERRIKEIVKKHSQFIGYPITLFVEKERDKEVS 229          
BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Match: ccdc173 (coiled-coil domain containing 173 [Source:Xenbase;Acc:XB-GENE-6258504])

HSP 1 Score: 979.163 bits (2530), Expect = 0.000e+0
Identity = 532/722 (73.68%), Postives = 625/722 (86.57%), Query Frame = 3
Query:   33 LMESMNDS-ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG----XXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++++M D  ETFAFQAEIAQL+SLIINTFYSNKEIFLRE+ISNSSDALDKIRY+SLTDPS LD+ KEL I +IP++   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K +DDEQY WESSAGGSFT++ D +EPLGRG+K+IL +KEDQ EYLEER+IKEI+K+HSQFIGYPI L +EKERDKE+SDDE+E +  +++ E+ +     +   DEE+D KK  KKKK  K K     +EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFS+EGQLEFRALLF P+RAPFDLFE+KKK+NNIKLYVRRVFIMDNCE+LIPEYLN +KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKK YEQF+KN+KLGIHEDS NR KL++ LRY+S++SG+EM SL +Y+SRMKENQK IYYITGE+KD V+HSAFVE L K G EV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE+K  FE LCKV+K+ILDKKVEKV +SNRLV SPCCIVTS +GWSANMERIMKAQALRD+STMGYMAAKKHLEIN DH +++ L+ + +ADKNDKSVKDLV LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLG       ++ E ++  + D+P  P   +++A +MEEVD
Sbjct:    1 MVQAMEDEVETFAFQAEIAQLMSLIINTFYSNKEIFLREIISNSSDALDKIRYESLTDPSKLDSGKELKIDLIPNRRDRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHSDDEQYAWESSAGGSFTVRADNTEPLGRGTKVILHLKEDQTEYLEERRIKEIVKRHSQFIGYPITLYMEKERDKEISDDESEEQIDEKKDEKKDKTEIEDVGSDEEEDAKKGDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSIEGQLEFRALLFVPRRAPFDLFESKKKKNNIKLYVRRVFIMDNCEELIPEYLNIIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKENYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYSSASGDEMISLSEYVSRMKENQKHIYYITGETKDQVSHSAFVEGLRKHGLEVIYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKVIKEILDKKVEKVLLSNRLVESPCCIVTSTYGWSANMERIMKAQALRDNSTMGYMAAKKHLEINCDHPIIETLRQKAEADKNDKSVKDLVNLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDSFAEEEEEESPAIQDMP--PLEGDEDASRMEEVD 720          
BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Match: ccdc173 (coiled-coil domain containing 173 [Source:Xenbase;Acc:XB-GENE-6258504])

HSP 1 Score: 976.852 bits (2524), Expect = 0.000e+0
Identity = 530/716 (74.02%), Postives = 621/716 (86.73%), Query Frame = 3
Query:   48 NDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG----XXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ ETFAFQAEIAQL+SLIINTFYSNKEIFLRE+ISNSSDALDKIRY+SLTDPS LD+ KEL I +IP++   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K +DDEQY WESSAGGSFT++ D +EPLGRG+K+IL +KEDQ EYLEER+IKEI+K+HSQFIGYPI L +EKERDKE+SDDE+E +  +++ E+ +     +   DEE+D KK  KKKK  K K     +EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFS+EGQLEFRALLF P+RAPFDLFE+KKK+NNIKLYVRRVFIMDNCE+LIPEYLN +KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKK YEQF+KN+KLGIHEDS NR KL++ LRY+S++SG+EM SL +Y+SRMKENQK IYYITGE+KD V+HSAFVE L K G EV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE+K  FE LCKV+K+ILDKKVEKV +SNRLV SPCCIVTS +GWSANMERIMKAQALRD+STMGYMAAKKHLEIN DH +++ L+ + +ADKNDKSVKDLV LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLG       ++ E ++  + D+P  P   +++A +MEEVD
Sbjct:    3 DEVETFAFQAEIAQLMSLIINTFYSNKEIFLREIISNSSDALDKIRYESLTDPSKLDSGKELKIDLIPNRRDRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHSDDEQYAWESSAGGSFTVRADNTEPLGRGTKVILHLKEDQTEYLEERRIKEIVKRHSQFIGYPITLYMEKERDKEISDDESEEQIDEKKDEKKDKTEIEDVGSDEEEDAKKGDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSIEGQLEFRALLFVPRRAPFDLFESKKKKNNIKLYVRRVFIMDNCEELIPEYLNIIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKENYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYSSASGDEMISLSEYVSRMKENQKHIYYITGETKDQVSHSAFVEGLRKHGLEVIYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKVIKEILDKKVEKVLLSNRLVESPCCIVTSTYGWSANMERIMKAQALRDNSTMGYMAAKKHLEINCDHPIIETLRQKAEADKNDKSVKDLVNLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDSFAEEEEEESPAIQDMP--PLEGDEDASRMEEVD 716          
BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Match: uck1 (uridine-cytidine kinase 1 [Source:Xenbase;Acc:XB-GENE-961187])

HSP 1 Score: 973 bits (2514), Expect = 0.000e+0
Identity = 516/709 (72.78%), Postives = 603/709 (85.05%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX--XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ K+L I IIP++   TLT+IDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D  EP+GRG+K+IL++KEDQ EYLEE+++KE +KKHSQFIGYPI L LEKER+KE+SDDE +    +++  + E+                                 LNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+C++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KNLKLGIHEDS NR KL++ LRYH++ +G+EM SL +Y+SRMKENQK IYYITGESKD VA+SAFVER+ KRGFEV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKK  EE K  FE LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINP+H +++ L+ + + DKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGI  D+  +E  +  V D  + P   +++A +MEEVD
Sbjct:   13 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKDLKIDIIPNRQERTLTVIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVLVITKHNDDEQYAWESSAGGSFTVKTDHGEPIGRGTKVILYLKEDQTEYLEEKRVKETVKKHSQFIGYPITLYLEKEREKEISDDENDKPKIEDKYIDQEE---------------------------------LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFTELAEDKENYKKFYEAFSKNLKLGIHEDSTNRKKLSELLRYHTSQTGDEMASLTEYVSRMKENQKSIYYITGESKDQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKMMEENKTKFESLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPEHPIVETLRQKAETDKNDKAVKDLVVLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDDDDATVEETSPSVAD-EIPPLEGDEDASRMEEVD 687          
BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Match: ccdc173 (coiled-coil domain containing 173 [Source:Xenbase;Acc:XB-GENE-6258504])

HSP 1 Score: 959.903 bits (2480), Expect = 0.000e+0
Identity = 526/721 (72.95%), Postives = 617/721 (85.58%), Query Frame = 3
Query:   36 MESMNDS-ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG----XXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            +++M D  ETFAFQAEIAQL+SLIINTFYSNKEIFLRE+ISNSSDALDKIRY+SLTDPS LD+ KEL I +IP++   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K +DDEQY WESSAGGSFT++ D +EPLGRG+K+IL +KEDQ EYLEER+IKEI+K+HSQFIGYPI L        E+SDDE+E +  +++ E+ +     +   DEE+D KK  KKKK  K K     +EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFS+EGQLEFRALLF P+RAPFDLFE+KKK+NNIKLYVRRVFIMDNCE+LIPEYLN +KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKK YEQF+KN+KLGIHEDS NR KL++ LRY+S++SG+EM SL +Y+SRMKENQK IYYITGE+KD V+HSAFVE L K G EV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE+K  FE LCKV+K+ILDKKVEKV +SNRLV SPCCIVTS +GWSANMERIMKAQALRD+STMGYMAAKKHLEIN DH +++ L+ + +ADKNDKSVKDLV LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLG       ++ E ++  + D+P  P   +++A +MEEVD
Sbjct:    5 VQAMEDEVETFAFQAEIAQLMSLIINTFYSNKEIFLREIISNSSDALDKIRYESLTDPSKLDSGKELKIDLIPNRRDRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHSDDEQYAWESSAGGSFTVRADNTEPLGRGTKVILHLKEDQTEYLEERRIKEIVKRHSQFIGYPITLY-------EISDDESEEQIDEKKDEKKDKTEIEDVGSDEEEDAKKGDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSIEGQLEFRALLFVPRRAPFDLFESKKKKNNIKLYVRRVFIMDNCEELIPEYLNIIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKENYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYSSASGDEMISLSEYVSRMKENQKHIYYITGETKDQVSHSAFVEGLRKHGLEVIYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKVIKEILDKKVEKVLLSNRLVESPCCIVTSTYGWSANMERIMKAQALRDNSTMGYMAAKKHLEINCDHPIIETLRQKAEADKNDKSVKDLVNLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDSFAEEEEEESPAIQDMP--PLEGDEDASRMEEVD 716          
BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Match: ccdc173 (coiled-coil domain containing 173 [Source:Xenbase;Acc:XB-GENE-6258504])

HSP 1 Score: 921.768 bits (2381), Expect = 0.000e+0
Identity = 512/716 (71.51%), Postives = 602/716 (84.08%), Query Frame = 3
Query:   48 NDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG----XXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ ETFAFQAEIAQL+SLIINTFYSNKEIFLRE+ISNSSDALDKIRY+SLTDPS LD+ KEL I +IP++   TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K +DDEQY WESSAGGSFT++ D +EPLGRG+K+IL +KEDQ EYLEER+IKEI+K+HSQFIGYPI L +EKERDKE+SDDE+E +  +++ E+ +     +   DEE+D KK  KKKK  K K     +EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFS+EGQLEFRALLF P+RAPFDLFE+KKK+NNIKLYVRRVFIMDNCE+LIPEYLN +KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKK YEQF+KN+KLGIHEDS NR KL++ LRY+S++SG+EM SL +Y+SRMKENQK IYYITGE+KD V+HSAFVE L K G EV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE+K  FE LCKV+K+ILDKKVEKV +SN                     RIMKAQALRD+STMGYMAAKKHLEIN DH +++ L+ + +ADKNDKSVKDLV LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLG       ++ E ++  + D+P  P   +++A +MEEVD
Sbjct:    3 DEVETFAFQAEIAQLMSLIINTFYSNKEIFLREIISNSSDALDKIRYESLTDPSKLDSGKELKIDLIPNRRDRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHSDDEQYAWESSAGGSFTVRADNTEPLGRGTKVILHLKEDQTEYLEERRIKEIVKRHSQFIGYPITLYMEKERDKEISDDESEEQIDEKKDEKKDKTEIEDVGSDEEEDAKKGDKKKKTKKIKEKYIDQEELNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSIEGQLEFRALLFVPRRAPFDLFESKKKKNNIKLYVRRVFIMDNCEELIPEYLNIIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKENYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYSSASGDEMISLSEYVSRMKENQKHIYYITGETKDQVSHSAFVEGLRKHGLEVIYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKVIKEILDKKVEKVLLSN---------------------RIMKAQALRDNSTMGYMAAKKHLEINCDHPIIETLRQKAEADKNDKSVKDLVNLLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDEDSFAEEEEEESPAIQDMP--PLEGDEDASRMEEVD 695          
BLAST of Heat shock protein 90 vs. Ensembl Mouse
Match: Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250])

HSP 1 Score: 676.396 bits (1744), Expect = 0.000e+0
Identity = 348/445 (78.20%), Postives = 401/445 (90.11%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG---DVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWE+HLAVKHFSVEGQLEFRALLF P+RAPFDLFEN+KK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY +RMKENQK IY+ITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+K  FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHS+++ L+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LEDPQ HANRI+RMIKLGLGIDEDD  +D T      ++P  P   +D+  +MEEVD
Sbjct:  291 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMP--PLEGDDDTSRMEEVD 733          

HSP 2 Score: 352.829 bits (904), Expect = 3.480e-110
Identity = 180/216 (83.33%), Postives = 199/216 (92.13%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDD 704
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ DT EP+GRG+K+IL +KEDQ EYLEER+IKEI+KKHSQFIGYPI L +EKERDKEVSDD
Sbjct:   18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDD 233          
BLAST of Heat shock protein 90 vs. Ensembl Mouse
Match: Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250])

HSP 1 Score: 676.396 bits (1744), Expect = 0.000e+0
Identity = 348/445 (78.20%), Postives = 401/445 (90.11%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG---DVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWE+HLAVKHFSVEGQLEFRALLF P+RAPFDLFEN+KK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY +RMKENQK IY+ITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+K  FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDHS+++ L+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LEDPQ HANRI+RMIKLGLGIDEDD  +D T      ++P  P   +D+  +MEEVD
Sbjct:  291 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYFITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVTKEGLELPEDEEEKKKQEEKKTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTVDDTSAAVTEEMP--PLEGDDDTSRMEEVD 733          

HSP 2 Score: 352.829 bits (904), Expect = 3.480e-110
Identity = 180/216 (83.33%), Postives = 199/216 (92.13%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDD 704
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ DT EP+GRG+K+IL +KEDQ EYLEER+IKEI+KKHSQFIGYPI L +EKERDKEVSDD
Sbjct:   18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDD 233          
BLAST of Heat shock protein 90 vs. Ensembl Mouse
Match: Hsp90ab1 (heat shock protein 90 alpha (cytosolic), class B member 1 [Source:MGI Symbol;Acc:MGI:96247])

HSP 1 Score: 656.366 bits (1692), Expect = 0.000e+0
Identity = 344/444 (77.48%), Postives = 400/444 (90.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+C++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KNLKLGIHEDS NR +L++ LRYH++ SG+EMTSL +Y+SRMKE QK IYYITGESK+ VA+SAFVER+ KRGFEV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK EE KA FE LCK+MK+ILDKKVEKVT+SNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+LEDPQ H+NRI+RMIKLGLGIDED++  +      VP  + P   +++A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFSELAEDKENYKKFYEAFSKNLKLGIHEDSTNRRRLSELLRYHTSQSGDEMTSLSEYVSRMKETQKSIYYITGESKEQVANSAFVERVRKRGFEVVYMTEPIDEYCVQQLKEFDGKSLVSVTKEGLELPEDEEEKKKMEESKAKFENLCKLMKEILDKKVEKVTISNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIVETLRQKAEADKNDKAVKDLVVLLFETALLSSGFSLEDPQTHSNRIYRMIKLGLGIDEDEVTAEEPSAA-VPDEIPPLEGDEDASRMEEVD 724          

HSP 2 Score: 339.732 bits (870), Expect = 2.622e-105
Identity = 171/213 (80.28%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL I IIP+    TLT++DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ D  EP+GRG+K+IL +KEDQ EYLEER++KE++KKHSQFIGYPI L LEKER+KE+S
Sbjct:   14 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELKIDIIPNPQERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVRADHGEPIGRGTKVILHLKEDQTEYLEERRVKEVVKKHSQFIGYPITLYLEKEREKEIS 226          
BLAST of Heat shock protein 90 vs. Ensembl Mouse
Match: Hsp90b1 (heat shock protein 90, beta (Grp94), member 1 [Source:MGI Symbol;Acc:MGI:98817])

HSP 1 Score: 379.793 bits (974), Expect = 1.099e-119
Identity = 200/413 (48.43%), Postives = 283/413 (68.52%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFE--NKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKD-ILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQAL---RDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            +N  KPIW R   +V +++Y  FYKS + + +D +A  HF+ EG++ F+++LF P  AP  LF+    KK + IKLYVRRVFI D+  D++P+YLNFVKGVVDS+DLPLN+SRE LQQ+K+LKVIRK LV+K L++ ++I ++K N   F+++F  N+KLG+ ED  NR +LA  LR+ S+    ++TSL  Y+ RMKE Q  IY++ G S+     S FVERL K+G+EV+Y+ +P+DEY +Q L E+DGK+   V KEG++  E E+ K+  E  +  FEPL   MKD  L  K+EK  VS RL  SPC +V SQ+GWS NMERIMKAQA    +D ST  Y + KK  EINP H +++ +  R+  D++DK+V DL ++L+ET+ L SG+ L D + + +RI RM++L L
Sbjct:  336 MNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYN-DTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSL 747          

HSP 2 Score: 205.682 bits (522), Expect = 1.689e-55
Identity = 112/207 (54.11%), Postives = 146/207 (70.53%), Query Frame = 3
Query:   54 SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFM----EALQAGADIS-MIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPI 659
            SE FAFQAE+ +++ LIIN+ Y NKEIFLRELISN+SDALDKIR  SLTD + L   +EL +KI  DK+   L + DTG+GMT+ +L+ NLGTIA+SGT  F+    EA + G   S +IGQFGVGFYS++LVADKV V SK N+D Q++WES +     I       LGRG+ I L +KE+  +YLE   IK +++K+SQFI +PI
Sbjct:   73 SEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFINFPI 279          
BLAST of Heat shock protein 90 vs. Ensembl Mouse
Match: Hsp90aa1 (heat shock protein 90, alpha (cytosolic), class A member 1 [Source:MGI Symbol;Acc:MGI:96250])

HSP 1 Score: 311.612 bits (797), Expect = 2.059e-101
Identity = 150/181 (82.87%), Postives = 166/181 (91.71%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYL 599
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ DT EP+GRG+K+IL +KEDQ EYL
Sbjct:   18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPSKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDTGEPMGRGTKVILHLKEDQTEYL 198          
BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Match: sp|P30946|HS90A_RABIT (Heat shock protein HSP 90-alpha OS=Oryctolagus cuniculus OX=9986 GN=HSP90AA1 PE=1 SV=2)

HSP 1 Score: 997.268 bits (2577), Expect = 0.000e+0
Identity = 518/710 (72.96%), Postives = 597/710 (84.08%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG---DVPVGPSATEDEAGKMEEVD 2177
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I +IP+K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT++ D  EP+GRG+K++L +KEDQ EYLEER+IKEI+KKHSQFIGYPI L +EKERDKEVSDDEA+    K E E+     + E+  D + D ++                 LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFEN+KK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDK+NYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY +RMKENQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VT              K   +   FE LCK+MKDIL+KKVEKV VSNRLV+SPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLE+NPDHS+++ L+ + +ADKNDKSVKDLV+LLYET+LLSSGF+LEDPQ HANRI+RMIKLGLGIDEDD   D T      ++P  P   +D+  +MEEVD
Sbjct:   18 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDAGEPMGRGTKVVLHLKEDQTEYLEERRIKEIVKKHSQFIGYPITLFVEKERDKEVSDDEAKQPDDKPEIEDVGSDEEEEEKKDGDIDQEE-----------------LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENRKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKENYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYCTRMKENQKHIYYITGETKDQVANSAFVERLRKHGLEVIYMIEPIDEYCVQQLKEFEGKTLVSVT--------------KEGLELTKFENLCKIMKDILEKKVEKVVVSNRLVTSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEVNPDHSIIETLRQKAEADKNDKSVKDLVILLYETALLSSGFSLEDPQTHANRIYRMIKLGLGIDEDDPTADDTAAAVTEEMP--PLEGDDDTSRMEEVD 694          
BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Match: sp|P02828|HSP83_DROME (Heat shock protein 83 OS=Drosophila melanogaster OX=7227 GN=Hsp83 PE=1 SV=1)

HSP 1 Score: 987.638 bits (2552), Expect = 0.000e+0
Identity = 542/715 (75.80%), Postives = 620/715 (86.71%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXX--XXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL IK+IP+K AGTLTIIDTGIGMTKSDL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVADKV V SK NDDEQY+WESSAGGSFT++ D SEPLGRG+KI+L++KEDQ +YLEE KIKEI+ KHSQFIGYPIKL++    EKE   + +DDE +   +K+E E  E K +    D++ D   KD KKKK IKEKY ++EELNKTKPIWTRNPDD+SQE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+R PFDLFEN+KKRNNIKLYVRRVFIMDNCEDLIPEYLNF+KGVVDSEDLPLNISREMLQQNK+LKVIRKNLVKK +EL EE+ EDK+NYKKFY+QF+KNLKLG+HEDS NR KLADFLR+H+++SG++  SL DY+SRMK+NQK +Y+ITGESKD V++SAFVER+  RGFEV+YM +PIDEY +Q LKEY GK+LV VTKEGLELPEDE EKKK EE KA FE LCK+MK ILD KVEKV VSNRLV SPCCIVTSQFGWSANMERIMKAQALRD++TMGYMA KK LEINPDH +++ L+ + DADKNDK+VKDLV+LL+ETSLLSSGF+L+ PQ+HA+RI+RMIKLGLGIDED+          GD P     TED A  MEEVD
Sbjct:    4 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTVTSKNNDDEQYVWESSAGGSFTVRADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKEGDEKKEMETDEPKIEDVGEDEDADKKDKDAKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFMKGVVDSEDLPLNISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYDQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLADYVSRMKDNQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDESEKKKREEDKAKFESLCKLMKSILDNKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVETLRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTDDAQSAGDAPSLVEDTED-ASHMEEVD 717          
BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Match: sp|P04809|HSP83_DROPS (Heat shock protein 83 OS=Drosophila pseudoobscura pseudoobscura OX=46245 GN=Hsp83 PE=3 SV=2)

HSP 1 Score: 986.867 bits (2550), Expect = 0.000e+0
Identity = 540/715 (75.52%), Postives = 618/715 (86.43%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG--XXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ KEL IK+IP+K AGTLTIIDTGIGMTKSDL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YL+AD+V V SK NDDEQY+WESSAGGSFT+K D SEPLGRG+KI+L++KEDQ +YLEE KIKEI+ KHSQFIGYPIKL++    EKE   + +DDE + +  K++ +  E K +    D++ D   KD KKKK IKEKY ++EELNKTKPIWTRNPDD+SQE+Y EFYKSLTNDWEDHL VKHFSVEGQLEFRALLF P+R PFDLFEN+KKRNNIKLYVRRVFIMDNCEDLIPEYLNF+KGVVDSEDLPLNISREMLQQNK+LKVIRKNLVKK +EL EE+ EDK+NYKKFYEQF+KNLKLG+HEDS NR KLADFLR+H+++SG++  SL DY+SRMKENQK +Y+ITGESKD V++SAFVER+  RGFEV+YM +PIDEY +Q LKEY GK+LV VTKEGLELPEDE EKKK EE KA FE LCK+MK ILD KVEKV VSNRLV SPCCIVTSQFGWSANMERIMKAQALRD++TMGYMA KK LEINPDH +++AL+ + DADKNDK+VKDLV+LL+ETSLLSSGF+L+ PQ+HA+RI+RMIKLGLG   DE     D    GD P     TED A  MEEVD
Sbjct:    4 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKELYIKLIPNKTAGTLTIIDTGIGMTKSDLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLIADRVTVTSKNNDDEQYVWESSAGGSFTVKADNSEPLGRGTKIVLYIKEDQTDYLEESKIKEIVNKHSQFIGYPIKLLVEKEREKEVSDDEADDEKKDDEAKKDMDTDEPKIEDVGEDEDADKKDKDGKKKKTIKEKYTEDEELNKTKPIWTRNPDDISQEEYGEFYKSLTNDWEDHLCVKHFSVEGQLEFRALLFIPRRTPFDLFENQKKRNNIKLYVRRVFIMDNCEDLIPEYLNFIKGVVDSEDLPLNISREMLQQNKVLKVIRKNLVKKTMELIEELTEDKENYKKFYEQFSKNLKLGVHEDSNNRAKLADFLRFHTSASGDDFCSLSDYVSRMKENQKHVYFITGESKDQVSNSAFVERVKARGFEVVYMTEPIDEYVIQHLKEYKGKQLVSVTKEGLELPEDEAEKKKREEDKAKFEGLCKLMKSILDSKVEKVVVSNRLVDSPCCIVTSQFGWSANMERIMKAQALRDTATMGYMAGKKQLEINPDHPIVEALRQKADADKNDKAVKDLVILLFETSLLSSGFSLDSPQVHASRIYRMIKLGLGIDEDEPMTTEDAHSGGDAPGLVEDTED-ASHMEEVD 717          
BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Match: sp|P06660|HSP85_TRYCR (Heat shock-like 85 kDa protein OS=Trypanosoma cruzi OX=5693 PE=3 SV=1)

HSP 1 Score: 846.269 bits (2185), Expect = 0.000e+0
Identity = 444/673 (65.97%), Postives = 554/673 (82.32%), Query Frame = 3
Query:   54 SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            +ETFAFQAEI QL+SLIINTFYSNKEIFLRELISNSSDA DKIRY+SLT+ +VL     L I+++PDK   TLT+ DTGIGMTK++L+NNLGTIARSGTKAFMEAL+AG D+SMIGQFGVGFYS+YLVAD+V V+SK NDDE Y WESSAGG+FT+ P     L RG++I+L +KEDQ EYLEER++K++IKKHS+FIGY I+L++EK  +KEV+D++ +     +  E  E K +    D EE + KK  KK K++ ++++ +   NK KP+WTR+P DV++E+YA FYK+++NDWE+ L+ KHFSVEGQLEFRA+LF PKRAPFD+FE  KKRNNIKLYVRRVFIMDNCEDL PE+L FV+GVVDSEDLPLNISRE LQQNKILKVIRKN+VKK LELFEEI E+K++YKKFYEQF KN+KLGIHEDS NR KL + LR+HS+ SGE+MT+LKDY++RMKE QK IYY+TG+SK  +  S F+E+  +RGFEVL+M +PIDEY +QQ+K+++ KK  C+TKEG+   E EEEKK+ EE+K A+E LCK MKD+L  KVEKV VS RL +SPC +VTS+FGWSA+ME+IM+ QALRDSS   YM +KK +EINP H ++K LK RV+AD+NDK+VKDLV LL++T+LL+SGF L+DP  +A RIHRMIKLGL
Sbjct:    2 TETFAFQAEINQLMSLIINTFYSNKEIFLRELISNSSDACDKIRYQSLTNQAVLGDESHLRIRVVPDKANKTLTVEDTGIGMTKAELVNNLGTIARSGTKAFMEALEAGGDMSMIGQFGVGFYSAYLVADRVTVVSKNNDDEAYTWESSAGGTFTVTPTPDCDLKRGTRIVLHLKEDQQEYLEERRLKDLIKKHSEFIGYDIELMVEKATEKEVTDEDEDEAAATKNEEGEEPKVEEVKDDAEEGEKKKKTKKVKEVTQEFVVQ---NKHKPLWTRDPKDVTKEEYAAFYKAISNDWEEPLSTKHFSVEGQLEFRAILFVPKRAPFDMFEPSKKRNNIKLYVRRVFIMDNCEDLCPEWLAFVRGVVDSEDLPLNISRENLQQNKILKVIRKNIVKKALELFEEIAENKEDYKKFYEQFGKNVKLGIHEDSANRKKLMELLRFHSSESGEDMTTLKDYVTRMKEGQKCIYYVTGDSKKKLETSPFIEQARRRGFEVLFMTEPIDEYVMQQVKDFEDKKFACLTKEGVHFEETEEEKKQREEEKTAYERLCKAMKDVLGDKVEKVVVSERLATSPCILVTSEFGWSAHMEQIMRNQALRDSSMSAYMMSKKTMEINPAHPIVKELKRRVEADENDKAVKDLVYLLFDTALLTSGFTLDDPTSYAERIHRMIKLGL 671          
BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Match: sp|P54651|HSC90_DICDI (Heat shock cognate 90 kDa protein OS=Dictyostelium discoideum OX=44689 GN=hspD PE=1 SV=2)

HSP 1 Score: 831.247 bits (2146), Expect = 0.000e+0
Identity = 460/715 (64.34%), Postives = 563/715 (78.74%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGA-DISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL--VLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL-----GXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            E F FQAEI QL+SLIINTFYSNKE+FLRELISN+SDALDKIRY+SLTD SVL++  EL IKIIPDK A TLT+ID+GIGMTK+D++ NLGTIARSGTK FME LQ+GA DISMIGQFGVGFYS+YLVAD V V SK NDDEQY+WESSAGG FTI  D +EPLGRG+KI+L MKEDQ++YL+E KIK ++KKHS+FI YPI L  + EKE D+E +                  K   E+  D + ++ +++K+KKK+K +  + + LNKTKP+WTRNP DV++E+Y  FYKS++NDWE+ LAVKHFSVEGQLEF+A+LF PK+APFDLFE+KKK NNIKLYV+RVFIMDNC D+IPEYLNFV+G+VDSEDLPLNISRE LQQNKIL VIRKNLVKKC+ELF EI E+ ++YKKFYE F+KNLKLG+HEDS NR K AD LRY ++ SG+E+ +LK+Y+ RMKE Q +IYYITGESK  V +S F+E L K+  EV+YM DPIDEY+VQQLKEYDGKKLV +TKEGL+L E E+EKKK E+ KAA E L K +KD+L  KVEKV +S RL +SPC +VTS++GWSANMERIMKAQALRDSS   YM++KK LE+NPDH +++ L  +  A +  K+ KD V LLYET+LL+SGF+L++P   A+RIHRMIKLGL          +   +TT   D+P  P    DE  +ME+VD
Sbjct:    7 ERFTFQAEINQLMSLIINTFYSNKEVFLRELISNASDALDKIRYQSLTDASVLESKTELEIKIIPDKTAKTLTLIDSGIGMTKTDMVKNLGTIARSGTKNFMEQLQSGAADISMIGQFGVGFYSAYLVADTVIVHSKNNDDEQYVWESSAGGEFTIALDHTEPLGRGTKIVLHMKEDQLDYLDETKIKNLVKKHSEFIQYPISLLTIKEKEVDEETT-----------------AKEGEEESTDAKIEEIEEEKEKKKVKVQEKEWDVLNKTKPLWTRNPSDVTKEEYNSFYKSISNDWEEPLAVKHFSVEGQLEFKAILFVPKKAPFDLFESKKKANNIKLYVKRVFIMDNCADIIPEYLNFVRGIVDSEDLPLNISRETLQQNKILTVIRKNLVKKCIELFNEIAENSEDYKKFYEAFSKNLKLGVHEDSQNREKFADLLRYQTSKSGDELVTLKEYVGRMKEGQNEIYYITGESKKAVENSPFIEGLKKKNLEVIYMCDPIDEYAVQQLKEYDGKKLVSITKEGLKLDETEDEKKKAEQDKAANEELLKQVKDVLGDKVEKVVLSTRLANSPCVLVTSEYGWSANMERIMKAQALRDSSMSSYMSSKKTLELNPDHPIVRDLAKK--AAEKSKTFKDFVYLLYETALLTSGFSLDEPSSFASRIHRMIKLGLSIQDDSSATTEESTNTTTSDDIP--PLEENDEPSEMEKVD 700          
BLAST of Heat shock protein 90 vs. TrEMBL
Match: C0KTP7 (90 kDa heat shock protein OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 1144.8 bits (2960), Expect = 0.000e+0
Identity = 624/714 (87.39%), Postives = 676/714 (94.68%), Query Frame = 3
Query:   42 SMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX--XXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            S  D+ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLD+AKEL+IKIIPDKDAGTLTIIDTG+GMTK+DLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLV+DKVQVISK NDDEQ+LWESSAGGSFTI+PD+SE LGRG+KIIL+MKEDQ+EYLEERK+K+IIKKHSQFIGYPIKLVLEKERDKE+SDDEAE E K+++  E  +     +  D+E+D+ K  K KKK K K    DEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKC+ELFEEIMEDK+NYKKFYEQFAKN+KLGIHEDSVNRNK+A+FLR++STSSG++++SLK+Y+SRMKENQKDIYYITGESK+NV HSAFVERLTKRG EVL M+DPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDE+EK+KFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQ+GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPD S+MK+LKTRVD+DKNDKSVKDLVMLLYETSLLSSGF LEDPQ+H NRIHRMIKLGLGI++DD+E++ TE GDVPV  S TE++AGKMEEVD
Sbjct:    2 SDTDTETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDSAKELMIKIIPDKDAGTLTIIDTGVGMTKADLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVSDKVQVISKSNDDEQFLWESSAGGSFTIRPDSSELLGRGTKIILYMKEDQIEYLEERKVKDIIKKHSQFIGYPIKLVLEKERDKEISDDEAEDEKKEDKEGESTEDKPKIEDLDDEEDENKKNKDKKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCIELFEEIMEDKENYKKFYEQFAKNIKLGIHEDSVNRNKIAEFLRFYSTSSGDDLSSLKEYVSRMKENQKDIYYITGESKENVCHSAFVERLTKRGLEVLLMVDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEDEKEKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDRSIMKSLKTRVDSDKNDKSVKDLVMLLYETSLLSSGFTLEDPQVHGNRIHRMIKLGLGIEDDDVEMEATEAGDVPVVASTTEEDAGKMEEVD 715          
BLAST of Heat shock protein 90 vs. TrEMBL
Match: A0A3M7S7W0 (Heat shock 83 OS=Brachionus plicatilis OX=10195 GN=BpHYR1_026422 PE=3 SV=1)

HSP 1 Score: 1023.08 bits (2644), Expect = 0.000e+0
Identity = 560/712 (78.65%), Postives = 635/712 (89.19%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXX---XXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDP  LDT KEL IKIIPDK + TLTIIDTGIGMTK+DL+NNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYS+YLVAD+V V +K NDDEQY WESSAGGSFT++ D SEPLGRG+KI+L MKEDQ EY +E+K+KEI+KKHSQFIGYPIKLV+EKERDKE+SDDEA+ E K+E+  E E     E  +    EE + +KDKKKKKKIKEKY DEEELNKTKP+WTRNP+D+SQ +Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF PKRAPFDLFENKK++N IKLYVRRVFIM+NCE+L+P+YLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLEL EEI EDKDNYKKFYEQF KN+KLGIHEDS NR KL+DFLR++++SSG+EMTSLKDY++RMKENQKD+Y+ITGES++ VA SAFVE++ KRGFEV+YM+DPIDEY VQQLKEY+GKKLV VTKEGLELPEDE+EKKK E     +E LCKVMKDILDKKVEKVT+SNRLVSSPCCIVTSQ+GWSANMERIMKAQALRD+STMGYMAAKKHLEINPDHS++K+LK++VD DKNDKSVKDLV LL+ETSLLSSGF+L+ PQ HA RI RMIK+GLGIDE++ E    E    PV      +EA +MEEVD
Sbjct:   12 EAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPHKLDTCKELYIKIIPDKASNTLTIIDTGIGMTKADLVNNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADRVVVTTKHNDDEQYTWESSAGGSFTVRLDNSEPLGRGTKIVLHMKEDQAEYNDEKKVKEIVKKHSQFIGYPIKLVVEKERDKEISDDEADEEQKQEDKTEQEQPKVEEIEEGSDKEEAETEKDKKKKKKIKEKYKDEEELNKTKPLWTRNPEDISQAEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFIPKRAPFDLFENKKQKNAIKLYVRRVFIMENCEELMPDYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELIEEISEDKDNYKKFYEQFGKNIKLGIHEDSTNRKKLSDFLRFYTSSSGDEMTSLKDYVARMKENQKDVYFITGESREVVASSAFVEKVKKRGFEVVYMVDPIDEYCVQQLKEYEGKKLVSVTKEGLELPEDEQEKKKRESDAEKYENLCKVMKDILDKKVEKVTISNRLVSSPCCIVTSQYGWSANMERIMKAQALRDTSTMGYMAAKKHLEINPDHSIIKSLKSKVDMDKNDKSVKDLVNLLFETSLLSSGFSLDHPQTHAERIFRMIKMGLGIDEEEGEQVVEEEAK-PVEDMPPLEEASRMEEVD 722          
BLAST of Heat shock protein 90 vs. TrEMBL
Match: A0A0M4HFL9 (Heat shock protein 90 OS=Macrostomum lignano OX=282301 GN=hsp90 PE=2 SV=1)

HSP 1 Score: 1019.99 bits (2636), Expect = 0.000e+0
Identity = 571/715 (79.86%), Postives = 639/715 (89.37%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXX--XXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDA+DKIRY+SLTD SVLD+ ++L IKIIP+K   +LTIID+GIGMTK+DL+NNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYS+YLVAD+V V SK NDDEQY+WESSAGGSFT++PD  EP+GRG+KI+L++KEDQ EY+EERK+KE+IKKHSQFIGYPIKLVL    EKE   + +++E E + +  E  E E     +DLDD ++D+K DKKKKKKIKEKYIDEEELNKTKPIWTRN DD++QE+Y EFYKSLTNDWE+HLAVKHFSVEGQLEFRALLF PKRAPFDLFEN+KKRNNIKLYVRRVFIMDNCE+LIPEYLNF+KGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKC+ELF++I EDK+N+KKFYEQF KNLKLGIHEDS NR KLAD+LRY+STSSG++ TSLKDY+SRMKENQKDIYYITGESK+ VAHSAFVERL KRG EVLYM DPIDEY+ QQL+EYDGKKLVCVTKEGLELPEDE+EKK FEE+KA+FEPLCKVMKDILDKKVEKV VSNRLV SPCCIVTSQ+GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS+   L+ R +ADKNDKSVKDLV LLYET+LLSSGFALEDPQ+HA RIHRMIKLGLGI+EDD+           +P  VG  A  D+A KMEEVD
Sbjct:    7 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDAIDKIRYQSLTDSSVLDSGRDLEIKIIPNKSDNSLTIIDSGIGMTKADLVNNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADRVVVTSKHNDDEQYVWESSAGGSFTVRPDHGEPIGRGTKIVLYLKEDQTEYIEERKVKEVIKKHSQFIGYPIKLVLEKEREKEVSDDEAEEEKEEKKEDGEDAEKEKPKVEDDLDDNDEDEKGDKKKKKKIKEKYIDEEELNKTKPIWTRNQDDITQEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPKRAPFDLFENRKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCMELFDDIAEDKENFKKFYEQFGKNLKLGIHEDSTNRKKLADYLRYYSTSSGDDWTSLKDYVSRMKENQKDIYYITGESKEAVAHSAFVERLRKRGLEVLYMTDPIDEYATQQLREYDGKKLVCVTKEGLELPEDEDEKKAFEEKKASFEPLCKVMKDILDKKVEKVVVSNRLVDSPCCIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSICGMLRQRTEADKNDKSVKDLVQLLYETALLSSGFALEDPQVHATRIHRMIKLGLGIEEDDVPDAAAGESSSSMPTEVGGDANADDA-KMEEVD 720          
BLAST of Heat shock protein 90 vs. TrEMBL
Match: A0A1C6ZXV8 (HSP90 OS=Cotesia chilonis OX=89804 GN=hsp90 PE=2 SV=1)

HSP 1 Score: 1019.61 bits (2635), Expect = 0.000e+0
Identity = 559/710 (78.73%), Postives = 638/710 (89.86%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXX-XXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ K+L IKIIP+K+  TLTIIDTGIGMTK+DL+NNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVADKV V SK NDDEQYLWES+AGGSFT++ D SEPLGRG+KI+L++KEDQ EYLEE KIKEI+KKHSQFIGYPIKLV++KER+KE+SDDEAE E + E+ E+   + K +    D+EED +K+ KKKKK IKEKY ++EELNKTKPIWTRNPDD++QE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+R PFDLFENKK++NNIKLYVRRVFIMDNCE+LIPEYLNF+KGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEE+ EDK+NYKKFYEQF+KNLKLGIHEDS NR+KLAD LRYH+++SGEE  SLKDY+ RMKENQK IY+ITGESK+ VA+S+FVER+ KRGFEV+YM +PIDEY VQQ+KE+DGK+LV VTKEGLELPEDE EKKK EE KA FE LCKVMK ILD KVEKV VSNRLV SPCCIVTSQ+GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH V++ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF+L+DPQ+HA RI+RMIKLGLGIDED+    +   + +VP   S +ED A +MEEVD
Sbjct:   13 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSGKDLSIKIIPNKNDRTLTIIDTGIGMTKADLVNNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADKVTVTSKHNDDEQYLWESAAGGSFTVRADNSEPLGRGTKIVLYIKEDQAEYLEESKIKEIVKKHSQFIGYPIKLVVQKEREKELSDDEAEPEAETEKKEDEDDKPKIEDVGEDEEEDKEKEKKKKKKTIKEKYTEDEELNKTKPIWTRNPDDITQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRMPFDLFENKKRKNNIKLYVRRVFIMDNCEELIPEYLNFMKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEELTEDKENYKKFYEQFSKNLKLGIHEDSSNRSKLADLLRYHTSASGEESCSLKDYVGRMKENQKHIYFITGESKEQVANSSFVERVKKRGFEVVYMTEPIDEYVVQQMKEFDGKQLVSVTKEGLELPEDEAEKKKREEDKAKFEELCKVMKTILDSKVEKVVVSNRLVDSPCCIVTSQYGWTANMERIMKAQALRDTSTMGYMAAKKHLEINPDHPVIENLRQKTEADKNDKSVKDLVVLLFETALLSSGFSLDDPQVHAARIYRMIKLGLGIDEDEPIGEEPKAMEEVPTLESESED-ASRMEEVD 721          
BLAST of Heat shock protein 90 vs. TrEMBL
Match: A0A267DD20 (HATPase_c domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig023254g4 PE=3 SV=1)

HSP 1 Score: 1016.91 bits (2628), Expect = 0.000e+0
Identity = 570/715 (79.72%), Postives = 639/715 (89.37%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL----EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXX--XXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDA+DKIRY+SLTD SVLD+ ++L IKIIP+K   +LTIID+GIGMTK+DL+NNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYS+YLVAD+V V SK NDDEQY+WESSAGGSFT++PD  EP+GRG+KI+L++KEDQ EY+EE+K+KE+IKKHSQFIGYPIKLVL    EKE   + +++E E + +  E  E E     +DLDD ++D+K DKKKKKKIKEKYIDEEELNKTKPIWTRN DD++QE+Y EFYKSLTNDWE+HLAVKHFSVEGQLEFRALLF PKRAPFDLFEN+KKRNNIKLYVRRVFIMDNCE+LIPEYLNF+KGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKC+ELF++I EDK+N+KKFYEQF KNLKLGIHEDS NR KLAD+LRY+STSSG++ TSLKDY+SRMKENQKDIYYITGESK+ VAHSAFVERL KRG EVLYM DPIDEY+ QQL+EYDGKKLVCVTKEGLELPEDE+EKK FEE+KA+FEPLCKVMKDILDKKVEKV VSNRLV SPCCIVTSQ+GWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS+   L+ R +ADKNDKSVKDLV LLYET+LLSSGFALEDPQ+HA RIHRMIKLGLGI+EDD+           +P  VG  A  D+A KMEEVD
Sbjct:    7 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDAIDKIRYQSLTDSSVLDSGRDLEIKIIPNKSDNSLTIIDSGIGMTKADLVNNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSAYLVADRVVVTSKHNDDEQYVWESSAGGSFTVRPDHGEPIGRGTKIVLYLKEDQTEYIEEKKVKEVIKKHSQFIGYPIKLVLEKEREKEVSDDEAEEEKEEKKEDGEDAEKEKPKVEDDLDDNDEDEKGDKKKKKKIKEKYIDEEELNKTKPIWTRNQDDITQEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPKRAPFDLFENRKKRNNIKLYVRRVFIMDNCEELIPEYLNFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCMELFDDIAEDKENFKKFYEQFGKNLKLGIHEDSTNRKKLADYLRYYSTSSGDDWTSLKDYVSRMKENQKDIYYITGESKEAVAHSAFVERLRKRGLEVLYMTDPIDEYATQQLREYDGKKLVCVTKEGLELPEDEDEKKAFEEKKASFEPLCKVMKDILDKKVEKVVVSNRLVDSPCCIVTSQYGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSICGMLRQRTEADKNDKSVKDLVQLLYETALLSSGFALEDPQVHATRIHRMIKLGLGIEEDDVPDAAAGESSSSMPTEVGGDANADDA-KMEEVD 720          
BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 665.996 bits (1717), Expect = 0.000e+0
Identity = 343/445 (77.08%), Postives = 392/445 (88.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF EI EDKDNYKK YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY+SRMK++QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKEYDGK L+ VTKEGLELPEDEEEKKK +E K  FE LCK+MKDILDKK+EKVTVSNRLV+SPCCIVTS +GW+ANMERIMK+QALRD+STMGYM AKKHLEINP H +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF LEDPQ HANRI+RMIKLGLGI   D    +I      D+PV     +D+  +MEEVD
Sbjct:  281 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCEELMPEYLNFMKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTEISEDKDNYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSNSGDEMVSLKDYVSRMKDSQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLLSVTKEGLELPEDEEEKKKQDELKTKFENLCKIMKDILDKKIEKVTVSNRLVASPCCIVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPLHPIVETLREKAEADKNDKAVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDDDDSAVEDILQPTEEDMPVLEG--DDDTSRMEEVD 723          

HSP 2 Score: 337.806 bits (865), Expect = 1.089e-104
Identity = 170/215 (79.07%), Postives = 197/215 (91.63%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            D ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS L++ K+L I++IPD    TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA++V VI+K NDDEQY+WES+AGGSFT+KPD  E +GRG+K+IL +KEDQ EY EE++IKE++KKHSQFIGYPI L +EK+R+KEV
Sbjct:   13 DVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLESCKDLKIELIPDLKNRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVTVITKHNDDEQYVWESAAGGSFTVKPDNGESIGRGTKVILHLKEDQSEYTEEKRIKEVVKKHSQFIGYPITLFVEKQREKEV 227          
BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 665.996 bits (1717), Expect = 0.000e+0
Identity = 343/445 (77.08%), Postives = 392/445 (88.09%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNCE+L+PEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF EI EDKDNYKK YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY+SRMK++QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKEYDGK L+ VTKEGLELPEDEEEKKK +E K  FE LCK+MKDILDKK+EKVTVSNRLV+SPCCIVTS +GW+ANMERIMK+QALRD+STMGYM AKKHLEINP H +++ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF LEDPQ HANRI+RMIKLGLGI   D    +I      D+PV     +D+  +MEEVD
Sbjct:  281 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCEELMPEYLNFMKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTEISEDKDNYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSNSGDEMVSLKDYVSRMKDSQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEYDGKNLLSVTKEGLELPEDEEEKKKQDELKTKFENLCKIMKDILDKKIEKVTVSNRLVASPCCIVTSTYGWTANMERIMKSQALRDNSTMGYMTAKKHLEINPLHPIVETLREKAEADKNDKAVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDDDDSAVEDILQPTEEDMPVLEG--DDDTSRMEEVD 723          

HSP 2 Score: 337.806 bits (865), Expect = 1.089e-104
Identity = 170/215 (79.07%), Postives = 197/215 (91.63%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            D ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS L++ K+L I++IPD    TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA++V VI+K NDDEQY+WES+AGGSFT+KPD  E +GRG+K+IL +KEDQ EY EE++IKE++KKHSQFIGYPI L +EK+R+KEV
Sbjct:   13 DVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLESCKDLKIELIPDLKNRTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVTVITKHNDDEQYVWESAAGGSFTVKPDNGESIGRGTKVILHLKEDQSEYTEEKRIKEVVKKHSQFIGYPITLFVEKQREKEV 227          
BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:103047517])

HSP 1 Score: 665.226 bits (1715), Expect = 0.000e+0
Identity = 349/444 (78.60%), Postives = 399/444 (89.86%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVP--VGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLA+KHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMD+CE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDKDNYKKFYE F+KN+KLGIHEDS NR KL++ LRYHS+ SG+EMTSL +YLSRMKENQK IYYITGESKD VA+SAFVER+ KRGFEVLYM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK E+ KA FE LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +M+ L+ + +ADKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGID+DD+  +       P  + P   +D+A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAIKHFSVEGQLEFRALLFIPRRAPFDLFENKKKKNNIKLYVRRVFIMDSCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFAELAEDKDNYKKFYESFSKNIKLGIHEDSQNRKKLSELLRYHSSQSGDEMTSLSEYLSRMKENQKSIYYITGESKDQVANSAFVERVRKRGFEVLYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEEEKKKMEDDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAEADKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDDDDIPSEEPTSAPAPEEIPPLEGDDDASRMEEVD 725          

HSP 2 Score: 338.191 bits (866), Expect = 1.009e-104
Identity = 169/213 (79.34%), Postives = 196/213 (92.02%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ K+L I IIP+K   TLT++DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D  EP+GRG+K+IL +KEDQ EY+E++++KE++KKHSQFIGYPI L +EKERDKE+S
Sbjct:   13 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKDLKIDIIPNKLERTLTLVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVITKHNDDEQYAWESSAGGSFTVKVDNGEPIGRGTKVILHLKEDQTEYIEDKRVKEVVKKHSQFIGYPITLYVEKERDKEIS 225          
BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 655.981 bits (1691), Expect = 0.000e+0
Identity = 345/445 (77.53%), Postives = 399/445 (89.66%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXX---XXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKP+WTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNC++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY++RMK+ QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+KA FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +++ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF L+DPQ H+NRI+RMIKLGLGIDE      E  +  + D+P  P   +D+  +MEEVD
Sbjct:  289 LNKTKPLWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKDNYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVTRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEFEGKNLVSVTKEGLELPEDEEEKKKQEEKKAQFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIIETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGIDEDDLSTEEPSSAPIEDMP--PLEGDDDTSRMEEVD 731          

HSP 2 Score: 345.895 bits (886), Expect = 1.334e-107
Identity = 178/216 (82.41%), Postives = 200/216 (92.59%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            D ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLT+PS LD+ K+L I+IIP+K+  TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D SEP+ RG+K+IL +KEDQ EY+EER+IKEI+KKHSQFIGYPI L +EKERDKEVS
Sbjct:   13 DVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTEPSKLDSGKDLKIEIIPNKEERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVKVDNSEPVNRGTKVILHLKEDQTEYIEERRIKEIVKKHSQFIGYPITLYVEKERDKEVS 228          
BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Match: hsp90aa1.2 (Astyanax mexicanus heat shock protein HSP 90-alpha 1-like (LOC103024454), mRNA. [Source:RefSeq mRNA;Acc:NM_001291257])

HSP 1 Score: 655.21 bits (1689), Expect = 0.000e+0
Identity = 345/445 (77.53%), Postives = 399/445 (89.66%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXX---XXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKP+WTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNC++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKKFYEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY++RMK+ QK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLKE++GK LV VTKEGLELPEDEEEKKK EE+KA FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +++ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF L+DPQ H+NRI+RMIKLGLGIDE      E  +  + D+P  P   +D+  +MEEVD
Sbjct:  288 LNKTKPLWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELAEDKDNYKKFYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVTRMKDTQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKEFEGKNLVSVTKEGLELPEDEEEKKKQEEKKAQFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIIETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLDDPQTHSNRIYRMIKLGLGIDEDDLSTEEPSSAPIEDMP--PLEGDDDTSRMEEVD 730          

HSP 2 Score: 345.125 bits (884), Expect = 2.133e-107
Identity = 177/217 (81.57%), Postives = 202/217 (93.09%), Query Frame = 3
Query:   48 NDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVS 698
            +++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLT+PS LD+ K+L I+IIP+K+  TLTIIDTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY WESSAGGSFT+K D SEP+ RG+K+IL +KEDQ EY+EER+IKEI+KKHSQFIGYPI L +EKERDKEVS
Sbjct:   11 DEAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTEPSKLDSGKDLKIEIIPNKEERTLTIIDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVKVDNSEPVNRGTKVILHLKEDQTEYIEERRIKEIVKKHSQFIGYPITLYVEKERDKEVS 227          
BLAST of Heat shock protein 90 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003399.1 (pep scaffold:Pmarinus_7.0:GL479675:6143:15195:1 gene:ENSPMAG00000002912.1 transcript:ENSPMAT00000003399.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 649.047 bits (1673), Expect = 0.000e+0
Identity = 339/442 (76.70%), Postives = 397/442 (89.82%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKP+WTRNPDD+SQE+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNCEDLIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKC+ELF  + EDK+NYKKFYEQF+KN+KLGIHEDS NR +L++ LRYH++ +GE++ SLK+Y+SRMKENQK IYYITGESK+ V++SAFVER+ KRG EV+YM +PIDEY VQQLKE+DGK LV VTKEGLELPEDE+EKKK EE KA +E LCKV+K+ILDKKVEKVTVSNRLV+SPCCIVTS +GW+ANMERIMKAQALRDSSTMGYMAAKKHLEINP+H +++ L+ + +ADKNDKSVKDL++LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGID+D+   D +        P    ++A +MEEVD
Sbjct:  260 LNKTKPLWTRNPDDISQEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEDLIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCMELFTGLAEDKENYKKFYEQFSKNMKLGIHEDSQNRKRLSEMLRYHTSVTGEDVCSLKEYVSRMKENQKHIYYITGESKEQVSNSAFVERVRKRGLEVVYMTEPIDEYCVQQLKEFDGKTLVSVTKEGLELPEDEDEKKKQEEAKAKYENLCKVVKEILDKKVEKVTVSNRLVASPCCIVTSTYGWTANMERIMKAQALRDSSTMGYMAAKKHLEINPEHPIVETLRQKAEADKNDKSVKDLIILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDDDEPIPDESTPTVTEEMPPLEGEDASRMEEVD 701          

HSP 2 Score: 279.256 bits (713), Expect = 1.604e-83
Identity = 147/218 (67.43%), Postives = 174/218 (79.82%), Query Frame = 3
Query:   51 DSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDD 704
            ++ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS +D+ KEL I +IP+++  T                            AFMEALQAGADISMIGQFGVGFYS+YL+A++V V++K NDDEQYLWESSAGGSFT++ D  E +GRG+KI+L +KEDQ EYLEE++IK+I+KKHSQFIGYPI L +EKERDKEVSDD
Sbjct:   13 ETETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKMDSGKELKIDVIPNRNERT----------------------------AFMEALQAGADISMIGQFGVGFYSAYLIAERVSVVTKHNDDEQYLWESSAGGSFTVRLDNGESIGRGTKIVLHLKEDQSEYLEEKRIKDIVKKHSQFIGYPITLFVEKERDKEVSDD 202          
BLAST of Heat shock protein 90 vs. Ensembl Sea Lamprey
Match: hsp90b1 (heat shock protein 90, beta (grp94), member 1 [Source:ZFIN;Acc:ZDB-GENE-031002-1])

HSP 1 Score: 337.421 bits (864), Expect = 1.458e-104
Identity = 182/413 (44.07%), Postives = 269/413 (65.13%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFE--NKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQ-LKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQAL---RDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            +N  KPIW R   +V  ++Y  FYKS + D ++ L   HF+ EG++ FR++LF P  AP  +F+    KK + IK+YVRRVFI D+  D++P+YLNFVKGVVDS+DLPLN+SRE LQQ+K+LKVI+K LV+K L++ ++I  D+   +KF+++F  N+KLG+ ED  NR +LA  LR+ S+   +++TSL++Y+ RMKE Q  IY+I G ++  V  S FVERL K+G+EVL++ + +DEY +Q  L ++       +      L             +  F  LC        +++EK TVS RL+ SPC +V SQ+GWS NMERIMKAQA    +D+++  Y + KK  EINP H ++K L TRV A + D + KDL ++L+ET+ L SG+ L+D +  ++RI RM+++ L
Sbjct:  313 MNDIKPIWQRVTKEVEDDEYKAFYKSFSKDSDEPLTWIHFTAEGEVTFRSILFVPTSAPRGMFDEYGTKKTDFIKMYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIKKKLVRKTLDMIKKIA-DESYQEKFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSYGTDKLTSLEEYVERMKEKQDKIYFIAGANRKEVESSPFVERLLKKGYEVLFLTEAVDEYCIQSDLGQFMDLYASILITAWSRLGPSLRVYAARFAVQRGFPLLCT-------RQIEKATVSQRLLGSPCALVASQYGWSGNMERIMKAQAYQTGKDAASNFYGSQKKTFEINPRHPLIKELLTRVQASEEDATAKDLALVLFETATLRSGYLLQDTRSFSDRIERMLRVSL 717          

HSP 2 Score: 154.066 bits (388), Expect = 3.902e-39
Identity = 94/203 (46.31%), Postives = 127/203 (62.56%), Query Frame = 3
Query:   54 SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDT-SEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPI 659
            +E   FQAE+ +++ LIIN+ Y NKEIFLRELISN+SDALDKIR  SLTD   LD   EL IKI  DK+   L I      ++++     L T  +S ++             +IGQFGVGFYS++LVAD++ V SK N+D Q++WES +   FT+  D     L RG+ I L +KE+  +YLE   IK ++KK+SQFI +PI
Sbjct:   75 AEKHVFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLMSLTDGKALDATDELTIKIKADKEKNLLHIF-----LSRA---QELATEGQSTSE-------------LIGQFGVGFYSAFLVADRIVVTSKHNNDTQHIWESDS-SEFTVTEDPRGNTLARGTTITLVLKEEAADYLELETIKNLVKKYSQFINFPI 255          
BLAST of Heat shock protein 90 vs. Ensembl Sea Lamprey
Match: hsp90ab1 (heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 2 [Source:ZFIN;Acc:ZDB-GENE-031001-3])

HSP 1 Score: 212.616 bits (540), Expect = 2.340e-63
Identity = 120/183 (65.57%), Postives = 138/183 (75.41%), Query Frame = 3
Query:  159 SSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDT-SEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDD 704
            S+ ALDKIRY+SLTDPS LDT KEL I IIP+K   TLT                           FMEALQAGADISMIGQFGVGFYS+YLVA++V V++K NDDEQY+WESSAGGSFT++PD   EPLGRG+KI+L +KEDQ EYLEER IK+I+KKHSQFIGYPI L +EKER+KEVSDD
Sbjct:    1 SAQALDKIRYESLTDPSKLDTGKELKIDIIPNKIDRTLT---------------------------FMEALQAGADISMIGQFGVGFYSAYLVAERVTVVTKHNDDEQYVWESSAGGSFTVRPDNDGEPLGRGTKIVLHIKEDQTEYLEERSIKDIVKKHSQFIGYPITLYVEKERNKEVSDD 156          

HSP 2 Score: 134.035 bits (336), Expect = 3.652e-35
Identity = 67/77 (87.01%), Postives = 73/77 (94.81%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVR 1082
            LNKTKP+WTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKK+NNIKLYVR
Sbjct:  214 LNKTKPLWTRNPDDITAEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKKNNIKLYVR 290          
BLAST of Heat shock protein 90 vs. Ensembl Yeast
Match: HSP82 (Hsp90 chaperone; redundant in function with Hsc82p; required for pheromone signaling, negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding, nucleotide addition; protein abundance increases in response to DNA replication stress; contains two acid-rich unstructured regions that promote solubility of chaperone-substrate complexes; HSP82 has a paralog, HSC82, that arose from the whole genome duplication [Source:SGD;Acc:S000006161])

HSP 1 Score: 780.4 bits (2014), Expect = 0.000e+0
Identity = 429/676 (63.46%), Postives = 542/676 (80.18%), Query Frame = 3
Query:   54 SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPD-TSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVD-ADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG 2075
            SETF FQAEI QL+SLIINT YSNKEIFLRELISN+SDALDKIRYKSL+DP  L+T  +L I+I P  +   L I D+GIGMTK++LINNLGTIA+SGTKAFMEAL AGAD+SMIGQFGVGFYS +LVAD+VQVISK NDDEQY+WES+AGGSFT+  D  +E +GRG+ + LF+K+DQ+EYLEE++IKE+IK+HS+F+ YPI+LV+ KE +KEV   E E + ++++ EE +D+   +   +E D++++ K K KK+KE+  + EELNKTKP+WTRNP D++QE+Y  FYKS++NDWED L VKHFSVEGQLEFRA+LF PKRAPFDLFE+KKK+NNIKLYVRRVFI D  EDLIPE+L+FVKGVVDSEDLPLN+SREMLQQNKI+KVIRKN+VKK +E F EI ED + ++KFY  F+KN+KLG+HED+ NR  LA  LRY+ST S +E+TSL DY++RM E+QK+IYYITGES   V  S F++ L  + FEVL++ DPIDEY+  QLKE++GK LV +T +  EL E +EEK + E++   +EPL K +K+IL  +VEKV VS +L+ +P  I T QFGWSANMERIMKAQALRDSS   YM++KK  EI+P   ++K LK RVD     DK+VKDL  LLYET+LL+SGF+L++P   A+RI+R+I LGL 
Sbjct:    3 SETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYKSLSDPKQLETEPDLFIRITPKPEQKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKSNDDEQYIWESNAGGSFTVTLDEVNERIGRGTILRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLVVTKEVEKEVPIPEEEKKDEEKKDEEKKDEDDKKPKLEEVDEEEEKKPKTKKVKEEVQEIEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFEKFYSAFSKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDIT-KDFELEETDEEKAEREKEIKEYEPLTKALKEILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTKLLYETALLTSGFSLDEPTSFASRINRLISLGLN 677          
BLAST of Heat shock protein 90 vs. Ensembl Yeast
Match: HSC82 (Cytoplasmic chaperone of the Hsp90 family; plays a role in determining prion variants; redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock; contains two acid-rich unstructured regions that promote the solubility of chaperone-substrate complexes; HSC82 has a paralog, HSP82, that arose from the whole genome duplication [Source:SGD;Acc:S000004798])

HSP 1 Score: 768.844 bits (1984), Expect = 0.000e+0
Identity = 437/712 (61.38%), Postives = 555/712 (77.95%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPD-TSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVD-ADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVG-DVPVG--PSATEDEAGKMEEVD 2177
            ETF FQAEI QL+SLIINT YSNKEIFLRELISN+SDALDKIRY++L+DP  L+T  +L I+I P  +   L I D+GIGMTK++LINNLGTIA+SGTKAFMEAL AGAD+SMIGQFGVGFYS +LVAD+VQVISK N+DEQY+WES+AGGSFT+  D  +E +GRG+ + LF+K+DQ+EYLEE++IKE+IK+HS+F+ YPI+L++     KEV  +    E +K++ E+ ++  K   L++ ++++++ K K KK+KE+  + EELNKTKP+WTRNP D++QE+Y  FYKS++NDWED L VKHFSVEGQLEFRA+LF PKRAPFDLFE+KKK+NNIKLYVRRVFI D  EDLIPE+L+FVKGVVDSEDLPLN+SREMLQQNKI+KVIRKN+VKK +E F EI ED + + KFY  FAKN+KLG+HED+ NR  LA  LRY+ST S +E+TSL DY++RM E+QK+IYYITGES   V  S F++ L  + FEVL++ DPIDEY+  QLKE++GK LV +T +  EL E +EEK + E++   +EPL K +KDIL  +VEKV VS +L+ +P  I T QFGWSANMERIMKAQALRDSS   YM++KK  EI+P   ++K LK RVD     DK+VKDL  LL+ET+LL+SGF+LE+P   A+RI+R+I LGL IDED+      E   + PV   P+ TE     MEEVD
Sbjct:    4 ETFEFQAEITQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPKQLETEPDLFIRITPKPEEKVLEIRDSGIGMTKAELINNLGTIAKSGTKAFMEALSAGADVSMIGQFGVGFYSLFLVADRVQVISKNNEDEQYIWESNAGGSFTVTLDEVNERIGRGTVLRLFLKDDQLEYLEEKRIKEVIKRHSEFVAYPIQLLV----TKEVEKEVPIPEEEKKDEEKKDEDDKKPKLEEVDEEEEEKKPKTKKVKEEVQELEELNKTKPLWTRNPSDITQEEYNAFYKSISNDWEDPLYVKHFSVEGQLEFRAILFIPKRAPFDLFESKKKKNNIKLYVRRVFITDEAEDLIPEWLSFVKGVVDSEDLPLNLSREMLQQNKIMKVIRKNIVKKLIEAFNEIAEDSEQFDKFYSAFAKNIKLGVHEDTQNRAALAKLLRYNSTKSVDELTSLTDYVTRMPEHQKNIYYITGESLKAVEKSPFLDALKAKNFEVLFLTDPIDEYAFTQLKEFEGKTLVDIT-KDFELEETDEEKAEREKEIKEYEPLTKALKDILGDQVEKVVVSYKLLDAPAAIRTGQFGWSANMERIMKAQALRDSSMSSYMSSKKTFEISPKSPIIKELKKRVDEGGAQDKTVKDLTNLLFETALLTSGFSLEEPTSFASRINRLISLGLNIDEDEETETAPEASTEAPVEEVPADTE-----MEEVD 705          
BLAST of Heat shock protein 90 vs. Ensembl Nematostella
Match: HSP90 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJ66])

HSP 1 Score: 683.715 bits (1763), Expect = 0.000e+0
Identity = 354/444 (79.73%), Postives = 399/444 (89.86%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGD--VPVGPSATEDEAGKMEEVD 2177
            LNKTKPIW RN D+++ E+Y EFYKSLTNDWE+HLAVKHFSVEGQLEFRALLF PKRAPFDLFE++KKRNNIKLYVRRVFIMDNCEDLIPEYL F+KGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKC+ELF EI ED+DNYKKFYEQF KNLKLGIHEDSVNR KLAD LRYHS+SSG+E+TSLKDY++RMKENQKDIY+ITGESKD V+HSAFVER+  RGFEVLYM++PIDEY++QQLKEYDGKKLV VTKEGLELPEDE+EKK  EE+ A +E LCKV+KDILDKK+EKV VS+RLVSSPCCIVTSQFGW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH++M +L+ +V+ADKNDKS+KDLVMLLYETSLL+SGF LEDPQ+H+ RI+RMI LGLGIDE+        V +   P+      D+A KMEEVD
Sbjct:  284 LNKTKPIWMRNADEITTEEYGEFYKSLTNDWEEHLAVKHFSVEGQLEFRALLFVPKRAPFDLFESRKKRNNIKLYVRRVFIMDNCEDLIPEYLGFIKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCMELFNEIAEDQDNYKKFYEQFGKNLKLGIHEDSVNRAKLADLLRYHSSSSGDELTSLKDYVTRMKENQKDIYFITGESKDQVSHSAFVERVKSRGFEVLYMVEPIDEYAIQQLKEYDGKKLVSVTKEGLELPEDEDEKKAREEKVAKYEGLCKVIKDILDKKIEKVVVSSRLVSSPCCIVTSQFGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHAIMDSLRKKVEADKNDKSLKDLVMLLYETSLLTSGFTLEDPQVHSGRIYRMIGLGLGIDEEPEAEGADAVTEDMPPLEGDDANDDASKMEEVD 727          

HSP 2 Score: 334.724 bits (857), Expect = 6.368e-104
Identity = 167/216 (77.31%), Postives = 197/216 (91.20%), Query Frame = 3
Query:   36 MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKER 683
            ME   D ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY SLTDPSVLD+ K+L I +IP+K+  +LTI D+G+GMTK+DL+NNLGTIA+SGTK FMEALQAGADISMIGQFGVGFYS+YLVA+KV V +K NDDEQY+WES+AGGSFT+K D+ EPLGRG+KI+L++KEDQ EYLEE++IKEI+KKHSQFIGYP+ L+++KER
Sbjct:   10 MEEDQDVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYLSLTDPSVLDSCKDLKITLIPNKEENSLTIQDSGVGMTKADLVNNLGTIAKSGTKTFMEALQAGADISMIGQFGVGFYSAYLVAEKVVVTTKHNDDEQYIWESAAGGSFTVKRDSGEPLGRGTKIVLYLKEDQTEYLEEKRIKEIVKKHSQFIGYPLSLLVQKER 225          
BLAST of Heat shock protein 90 vs. Ensembl Nematostella
Match: EDO45344 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RT97])

HSP 1 Score: 360.533 bits (924), Expect = 2.157e-112
Identity = 202/414 (48.79%), Postives = 293/414 (70.77%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFEN-KKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXX-XXXXXXXXXXXXXXXXXXXXXXXLCKVMK-DILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQAL---RDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLG 2075
            LN  KPIWTR P ++  ++Y EFYKS T + ED LA  HF  EG++ FR++LF PK AP +LF +  KK + IKL+VRRVFI DN E+++P+YL+F++GVVDS+DLPLN+SRE LQQ+K+LKVI+K LV+K L++ ++I ++ D    F+++++ N+KLG+ ED  NR +LA  LR++S++S ++MTSL +Y+ RMKE Q  IY++ G ++  V  S FVE+L K G+EVLY+I+P+DEY +Q L E++GKK   V KE      + +++KKKFEE +  +EPL K +K D L  ++EK T+S RL  SPC +V S +GWS NMERIM++QA     D S   Y   KK LE+NP H ++K L  RV+ +K+D++ KDL  +L+ET+ L SG+ ++D    A RI RM++L +G
Sbjct:  353 LNTNKPIWTRKPKEIKDDEYNEFYKSFTKESEDPLAKIHFVAEGEVTFRSILFVPKAAPSNLFSDYGKKMDAIKLFVRRVFITDNFEEMMPKYLSFIRGVVDSDDLPLNVSREQLQQHKLLKVIKKKLVRKALDMIKKIPKE-DYMATFWKEYSTNIKLGVIEDHSNRTRLAKLLRFYSSNSEKDMTSLAEYIERMKEKQDVIYFMAGHNRKEVESSPFVEKLLKEGYEVLYLIEPVDEYCMQSLPEFEGKKFQNVAKEGLKIGEDSDKKKKKFEELEKTYEPLLKWLKEDALKDQIEKATISERLHDSPCALVASSYGWSGNMERIMRSQAYAKSSDPSNEYYATQKKTLEVNPRHPLVKQLLKRVEENKDDQTAKDLSRILFETATLRSGYLVKDSADFAGRIERMLRLSMG 765          

HSP 2 Score: 217.238 bits (552), Expect = 7.355e-60
Identity = 124/225 (55.11%), Postives = 156/225 (69.33%), Query Frame = 3
Query:   21 FNINLMESMND-SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGAD----ISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEP-LGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEK 677
             N+  M+ + D +E   FQAE+ +++ LIIN+ Y NKEIFLRELISNSSDALDKIR  SLTD +  D+  EL IKI  DK+   L + DTGIGMTK +LI NLGTIA+SGT  F + +Q  A       +IGQFGVGFYSS+LVAD+V V SK NDD+QY+WES A  SF+I  D   P L RG+ I L +KE+  +YLE   IK+++KK+SQFI +PI L   K
Sbjct:   64 LNVAQMKELRDKAEKHEFQAEVNRMMKLIINSLYRNKEIFLRELISNSSDALDKIRLMSLTDKTAFDSGDELSIKIKADKENNILHVTDTGIGMTKEELIKNLGTIAKSGTSEFFQKIQEAASSDSASDLIGQFGVGFYSSFLVADRVIVTSKNNDDKQYIWESDA-SSFSISEDPRGPTLKRGTTISLHLKEEARDYLEPETIKDLVKKYSQFINFPIFLWTSK 287          
BLAST of Heat shock protein 90 vs. Ensembl Nematostella
Match: EDO45666 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RS03])

HSP 1 Score: 170.629 bits (431), Expect = 8.310e-45
Identity = 91/204 (44.61%), Postives = 138/204 (67.65%), Query Frame = 3
Query:   69 FQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADIS---MIGQFGVGFYSSYLVADKVQVISKG--NDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKL 665
            FQAE  QLL ++  + YS KE+F+RE+ISN+SDAL+K+R+  LT   V +T   L I I  D++AGT TI D G+GMT+ +L+++LG IA+SG+K FME L+  A  S   +IGQFGVGFYS+++VADKV V +K    + + Y W S   GS+      +  + RG+K++L +KED   +  +  +++I++++S F+G+PI L
Sbjct:   15 FQAETKQLLDIVAKSLYSEKEVFIREVISNASDALEKVRHFFLTGKDVSETETSLEIMIETDQEAGTFTIQDNGVGMTEEELMDHLGVIAKSGSKVFMEKLKNEARSSHENIIGQFGVGFYSTFMVADKVDVYTKSYQPNSQGYFWTSDGSGSYEYA--EANGVARGTKLVLHLKEDCKRFAMKTAVEDIVQRYSNFVGFPIYL 216          

HSP 2 Score: 164.851 bits (416), Expect = 6.403e-43
Identity = 105/367 (28.61%), Postives = 192/367 (52.32%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELF-EEIMEDKDNYKKFYEQFAKNLKLGI--HEDSVNRNKLADFLRYHSTSSGE-EMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTX--XXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDK-KVEKVTVSNRLVSS--PCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALK 1925
            +N  +P+WT  P D+S+E + EFY+ L+  ++      H+  +  L  R++ + P+  P  +F  ++  + I LY RRV I    E ++P +L F++GVVDSED+PLN+SRE+LQ + ++K +   L  + ++   E+  +D+  Y+KF++     ++ G+   ED   + ++A  L + S++     +T+L  Y+SRMK  QK +YY+   S+D    S + E L +   EVL+  +  D+  +  L++Y+ K ++         E  + + E +  +      + L   M  IL   +V  V VS RL ++  P  I       + +  +++K +  ++   M Y   +  LEINP H ++K L+
Sbjct:  221 INTIQPLWTLEPRDISKEQHDEFYQFLSKGYDKPRYYLHYKTDAPLNIRSIFYFPETLP-QMFNMQQMESGISLYSRRVLIQAKAEKVLPRWLRFIRGVVDSEDIPLNLSRELLQDSALIKKLSNVLSARLVKFLQEQARKDRVKYEKFFKDCGIFIREGVVTTEDEEQKEEIAKLLLFESSNEKPGTLTNLPAYVSRMKPTQKKVYYLCAPSRDLAETSPYYETLKQNDVEVLFSYNEQDDVVLHYLRKYENKAVISAENFLSEAEDTKPKNEPEVEDVTPEEGKDLAGWMSSILGPTRVVGVKVSKRLANTNHPAMITVPDMVAAKHWLKLIKTEHNKEVENMKYQIIQPTLEINPKHDLIKRLE 586          
BLAST of Heat shock protein 90 vs. Ensembl Medaka
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:100125466])

HSP 1 Score: 952.97 bits (2462), Expect = 0.000e+0
Identity = 533/712 (74.86%), Postives = 619/712 (86.94%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL--EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX----XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ K+L I IIP+K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA++V VI+K NDDEQY WESSAGGSFT+K D+ EP+GRG+KIIL +KEDQ EY+EE+++KEI+KKHSQFIGYPI L +  E++++    + E E E K+ + E  +     +   D+E+D K   KKKKKIKEKYID+EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KN+KLGIHEDS NR KL++ LRYHS+ SG+EMTSL +YLSRMKENQK IYYITGESKD VA+SAFVER+ KRGFEVLYM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK E+ KA FE LCK+MK+ILDKKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +M+ L+ + + DKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGI       +    T+   ++P      +D++ +MEEVD
Sbjct:   13 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKDLKIDIIPNKADRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVVVITKHNDDEQYAWESSAGGSFTVKVDSGEPIGRGTKIILHLKEDQTEYIEEKRVKEIVKKHSQFIGYPITLFVEKERDKEISDDEAEEEKEEKETKEEGEDKPKIEDVGSDDEEDAKDKGKKKKKIKEKYIDQEELNKTKPIWTRNPDDITSEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFGELAEDKENYKKFYEGFSKNIKLGIHEDSQNRKKLSELLRYHSSQSGDEMTSLTEYLSRMKENQKSIYYITGESKDQVANSAFVERVRKRGFEVLYMTEPIDEYCVQQLKEFDGKNLVSVTKEGLELPEDEEEKKKMEDDKAKFENLCKLMKEILDKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAETDKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDDDDIPTEEPASTSAPEEMPPLEGDADDDSSRMEEVD 724          
BLAST of Heat shock protein 90 vs. Ensembl Medaka
Match: hsp90ab1 (heat shock protein 90 alpha family class B member 1 [Source:NCBI gene;Acc:100125466])

HSP 1 Score: 922.924 bits (2384), Expect = 0.000e+0
Identity = 521/712 (73.17%), Postives = 605/712 (84.97%), Query Frame = 3
Query:   60 TFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVL--EKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX----XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            TFAFQAEIAQL+SLIINTFYSNKEIFLRELISN+SDALDKIRY+SLTDPS LD+ K+L I IIP+K   TLTI+DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA++V VI+K NDDEQY WESSAGGSFT+K D+ EP+GRG+KIIL +KEDQ EY+EE+++KEI+KKHSQFIGYPI L +  E++++    + E E E K+ + E  +     +   D+E+D K   KKKKKIKEKYID+EELNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RAPFDLFENKKK+NNIKLYVRRVFIMDNCE+LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKN+VKKCLELF E+ EDK+NYKKFYE F+KN+KLGIHEDS NR KL++ LRYHS+ SG+EMTSL +YLSRMKENQK IYYITGESKD VA+SAFVER+ KRGFEVLYM +PIDEY VQQLKE+DGK LV VTKEGLELPEDEEEKKK E+                 KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYM AKKHLEINPDH +M+ L+ + + DKNDK+VKDLV+LL+ET+LLSSGF+L+DPQ H+NRI+RMIKLGLGI       +    T+   ++P      +D++ +MEEVD
Sbjct:   13 TFAFQAEIAQLMSLIINTFYSNKEIFLRELISNASDALDKIRYESLTDPSKLDSGKDLKIDIIPNKADRTLTIVDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAERVVVITKHNDDEQYAWESSAGGSFTVKVDSGEPIGRGTKIILHLKEDQTEYIEEKRVKEIVKKHSQFIGYPITLFVEKERDKEISDDEAEEEKEEKETKEEGEDKPKIEDVGSDDEEDAKDKGKKKKKIKEKYIDQEELNKTKPIWTRNPDDITSEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAPFDLFENKKKKNNIKLYVRRVFIMDNCEELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNIVKKCLELFGELAEDKENYKKFYEGFSKNIKLGIHEDSQNRKKLSELLRYHSSQSGDEMTSLTEYLSRMKENQKSIYYITGESKDQVANSAFVERVRKRGFEVLYMTEPIDEYCVQQLKEFDGKNLVSVTKEGLELPEDEEEKKKMEDD----------------KKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMMAKKHLEINPDHPIMETLRQKAETDKNDKAVKDLVILLFETALLSSGFSLDDPQTHSNRIYRMIKLGLGIDDDDIPTEEPASTSAPEEMPPLEGDADDDSSRMEEVD 708          
BLAST of Heat shock protein 90 vs. Ensembl Medaka
Match: hsp90aa1.2 (heat shock protein HSP 90-alpha [Source:NCBI gene;Acc:101169506])

HSP 1 Score: 680.248 bits (1754), Expect = 0.000e+0
Identity = 351/445 (78.88%), Postives = 397/445 (89.21%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNC++LIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKK YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY+SRMK+NQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLK++DGK LV VTKEGLELPEDEEEKKK EE+KA FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +M+ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF LEDPQ HANRI+RMIKLGLGI   D    E  +    D+P  P   +D+A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCDELIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKDNYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVSRMKDNQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKDFDGKNLVSVTKEGLELPEDEEEKKKQEEKKAQFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIMETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDEDDTPVEETTSAPTEDMP--PLEGDDDASRMEEVD 724          

HSP 2 Score: 340.887 bits (873), Expect = 9.211e-106
Identity = 173/213 (81.22%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I++ PD  A TLTI DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY+WES+AGGSFT+KPD  EP+GRG+K+IL +KEDQ EY EE++IKE+IKKHSQFIGYPI L +EK R+KEV
Sbjct:   14 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKELKIEVRPDLHARTLTINDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPDNGEPIGRGTKVILHLKEDQTEYCEEKRIKEVIKKHSQFIGYPITLYVEKTREKEV 226          
BLAST of Heat shock protein 90 vs. Ensembl Medaka
Match: hsp90aa1.2 (heat shock protein HSP 90-alpha [Source:NCBI gene;Acc:101169506])

HSP 1 Score: 679.478 bits (1752), Expect = 0.000e+0
Identity = 350/445 (78.65%), Postives = 397/445 (89.21%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNC++LIPEYLNF+KGVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKK YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY++RMK+NQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLK++DGK LV VTKEGLELPEDEEEKKK EE+KA FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +M+ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF LEDPQ HANRI+RMIKLGLGI   D    E  +    D+P  P   +D+A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCDELIPEYLNFIKGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKDNYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVTRMKDNQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKDFDGKNLVSVTKEGLELPEDEEEKKKQEEKKAQFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIMETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDEDDTPVEETTSAPTEDMP--PLEGDDDASRMEEVD 724          

HSP 2 Score: 340.887 bits (873), Expect = 8.293e-106
Identity = 173/213 (81.22%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I++ PD  A TLTI DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY+WES+AGGSFT+KPD  EP+GRG+K+IL +KEDQ EY EE++IKE+IKKHSQFIGYPI L +EK R+KEV
Sbjct:   14 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKELKIEVRPDLHARTLTINDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPDNGEPIGRGTKVILHLKEDQTEYCEEKRIKEVIKKHSQFIGYPITLYVEKTREKEV 226          
BLAST of Heat shock protein 90 vs. Ensembl Medaka
Match: hsp90aa1.2 (heat shock protein HSP 90-alpha [Source:NCBI gene;Acc:101169506])

HSP 1 Score: 678.707 bits (1750), Expect = 0.000e+0
Identity = 349/445 (78.43%), Postives = 397/445 (89.21%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX---XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD++ E+Y EFYKSLTNDWEDHLAVKHFSVEGQLEFRALLF P+RA FDLFENKKKRNNIKLYVRRVFIMDNC++LIPEYLNF++GVVDSEDLPLNISREMLQQ+KILKVIRKNLVKKCLELF E+ EDKDNYKK YEQF+KN+KLGIHEDS NR KL++ LRY++++SG+EM SLKDY++RMK+NQK IYYITGE+KD VA+SAFVERL K G EV+YMI+PIDEY VQQLK++DGK LV VTKEGLELPEDEEEKKK EE+KA FE LCK+MKDIL+KKVEKVTVSNRLVSSPCCIVTS +GW+ANMERIMKAQALRD+STMGYMAAKKHLEINPDH +M+ L+ + +ADKNDKSVKDLV+LL+ET+LLSSGF LEDPQ HANRI+RMIKLGLGI   D    E  +    D+P  P   +D+A +MEEVD
Sbjct:  282 LNKTKPIWTRNPDDITNEEYGEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFVPRRAAFDLFENKKKRNNIKLYVRRVFIMDNCDELIPEYLNFIRGVVDSEDLPLNISREMLQQSKILKVIRKNLVKKCLELFTELSEDKDNYKKLYEQFSKNIKLGIHEDSQNRKKLSELLRYYTSASGDEMVSLKDYVTRMKDNQKHIYYITGETKDQVANSAFVERLRKAGLEVIYMIEPIDEYCVQQLKDFDGKNLVSVTKEGLELPEDEEEKKKQEEKKAQFENLCKIMKDILEKKVEKVTVSNRLVSSPCCIVTSTYGWTANMERIMKAQALRDNSTMGYMAAKKHLEINPDHPIMETLRQKAEADKNDKSVKDLVILLFETALLSSGFTLEDPQTHANRIYRMIKLGLGIDEDDTPVEETTSAPTEDMP--PLEGDDDASRMEEVD 724          

HSP 2 Score: 340.887 bits (873), Expect = 8.120e-106
Identity = 173/213 (81.22%), Postives = 195/213 (91.55%), Query Frame = 3
Query:   57 ETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEV 695
            ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRY+SLTDPS LD+ KEL I++ PD  A TLTI DTGIGMTK+DLINNLGTIA+SGTKAFMEALQAGADISMIGQFGVGFYS+YLVA+KV VI+K NDDEQY+WES+AGGSFT+KPD  EP+GRG+K+IL +KEDQ EY EE++IKE+IKKHSQFIGYPI L +EK R+KEV
Sbjct:   14 ETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYESLTDPSKLDSCKELKIEVRPDLHARTLTINDTGIGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGVGFYSAYLVAEKVTVITKHNDDEQYIWESAAGGSFTVKPDNGEPIGRGTKVILHLKEDQTEYCEEKRIKEVIKKHSQFIGYPITLYVEKTREKEV 226          
BLAST of Heat shock protein 90 vs. Planmine SMEST
Match: SMESG000024822.1 (SMESG000024822.1)

HSP 1 Score: 1231.47 bits (3185), Expect = 0.000e+0
Identity = 714/714 (100.00%), Postives = 714/714 (100.00%), Query Frame = 3
Query:   36 MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLEERKIKEIIKKHSQFIGYPIKLVLEKERDKEVSDDEAETETKKEESEEGEDKPKIEDLDDEEDDDKKDKKKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEEEKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGIDEDDMEIDTTEVGDVPVGPSATEDEAGKMEEVD
Sbjct:    1 MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLEERKIKEIIKKHSQFIGYPIKLVLEKERDKEVSDDEAETETKKEESEEGEDKPKIEDLDDEEDDDKKDKKKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEEEKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGIDEDDMEIDTTEVGDVPVGPSATEDEAGKMEEVD 714          
BLAST of Heat shock protein 90 vs. Planmine SMEST
Match: SMESG000071533.1 (SMESG000071533.1)

HSP 1 Score: 1169.84 bits (3025), Expect = 0.000e+0
Identity = 645/714 (90.34%), Postives = 684/714 (95.80%), Query Frame = 3
Query:   42 SMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXX--XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            S  D+ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLD+AK+L+IKIIPDKDAGTLTIIDTGIGMTK+DLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISK NDDEQYLWESSAGGSFTIK D SEP+GRGSK+IL+MKEDQ+EYL+E+KIKEIIKKHSQFIGYPIKLVLEKERDKE+SDDEAE   + +KE  +  +     +  D+E+DD K   KKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKN+KLGIHEDSVNRNK+A+FLR++STSSGEEMTSLKDY+SRMKENQKDIYYITGESKDNV HSAFVERLTKRGFEVL M+DPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDE+EKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS+MK+LK RVDADKNDKSVKDLVMLL+ETSLLSSGF+LEDPQ+H NRIHRMIKLGLGI++DD+EID TE GD+PVGP++TEDEAGKMEEVD
Sbjct:    2 SETDAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDSAKDLMIKIIPDKDAGTLTIIDTGIGMTKADLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKSNDDEQYLWESSAGGSFTIKYDNSEPIGRGSKVILYMKEDQIEYLDEKKIKEIIKKHSQFIGYPIKLVLEKERDKEISDDEAEVDDKKEKESEDTEDKPKIEDLDDEEDDDKKDKDKKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNIKLGIHEDSVNRNKIAEFLRFYSTSSGEEMTSLKDYISRMKENQKDIYYITGESKDNVIHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEDEKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKSLKLRVDADKNDKSVKDLVMLLFETSLLSSGFSLEDPQVHGNRIHRMIKLGLGIEDDDVEIDATEAGDIPVGPTSTEDEAGKMEEVD 715          
BLAST of Heat shock protein 90 vs. Planmine SMEST
Match: SMESG000071531.1 (SMESG000071531.1)

HSP 1 Score: 771.541 bits (1991), Expect = 0.000e+0
Identity = 403/430 (93.72%), Postives = 424/430 (98.60%), Query Frame = 3
Query:  888 DDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGXXXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            +DVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKN+KLGIHEDSVNRNK+A+FLR++STSSGEEMTSLKDY++RMKENQKDIYYITGESKDNV HSAFVERLTKRGFEVL M+DPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDE+EKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS+MK+LK RVDADKNDKSVKDLVMLL+ETSLLSSGF+LEDPQ+H NRIHRMIKLGLGI++DD+EID TE GD+PVGP++TEDEAGKMEEVD
Sbjct:  267 NDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNIKLGIHEDSVNRNKIAEFLRFYSTSSGEEMTSLKDYITRMKENQKDIYYITGESKDNVIHSAFVERLTKRGFEVLLMVDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEDEKKKFEEQKAAFEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKSLKLRVDADKNDKSVKDLVMLLFETSLLSSGFSLEDPQVHGNRIHRMIKLGLGIEDDDVEIDATEAGDIPVGPTSTEDEAGKMEEVD 696          

HSP 2 Score: 395.201 bits (1014), Expect = 6.376e-127
Identity = 203/221 (91.86%), Postives = 216/221 (97.74%), Query Frame = 3
Query:   42 SMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDD 704
            S  D+ETFAFQAEIAQL+SLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLD+AK+L+IKIIPDKDAGTLTIIDTGIGMTK+DLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISK NDDEQYLWESSAGGSFTIK D SEP+GRGSK+IL+MKEDQ+EYL+E+KIKEIIKKHSQFIGYPIKLVLEKERDKE+SDD
Sbjct:    2 SETDAETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDSAKDLMIKIIPDKDAGTLTIIDTGIGMTKADLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKSNDDEQYLWESSAGGSFTIKYDNSEPIGRGSKVILYMKEDQIEYLDEKKIKEIIKKHSQFIGYPIKLVLEKERDKEISDD 222          
BLAST of Heat shock protein 90 vs. Planmine SMEST
Match: SMESG000025598.1 (SMESG000025598.1)

HSP 1 Score: 738.413 bits (1905), Expect = 0.000e+0
Identity = 381/443 (86.00%), Postives = 419/443 (94.58%), Query Frame = 3
Query:  852 LNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGLGX-XXXXXXXXXXXVGDVPVGPSATEDEAGKMEEVD 2177
            LNKTKPIWTRNPDD+SQEDY+EFYKSL+NDWEDHLAVKHF+VEGQLEF+A+LFCPKRA FD+FENKKKRNNIKLYVRRVFIMDNCEDLIPEYL+F+KGVVDSEDLPLNISREMLQQNKILKV+RKN+VKKC+ELF+EIMEDKDNYKKFYEQFAKN+KLGIHEDSVNRNKLA+FLRY+STSSGEEM SLKDY+SRMKENQKDIYYITGE+K+ VA SAFVERL+KRGFEVL+M+DPIDEYSVQQLKE+DGKKLVCVTKEGLELPEDEEEKKKFEEQKA FE LCKVMKD+LDKKVEKVTVSNRLV SPCC+VTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHS+MK+LK RVD DKNDK+VKDL+ LL+ETSLL+SGF+LE+PQ+H NRIHRMIKLGLGI +E+ +E  T  V D  + PSA EDE  KMEEVD
Sbjct:  268 LNKTKPIWTRNPDDISQEDYSEFYKSLSNDWEDHLAVKHFAVEGQLEFKAILFCPKRASFDMFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLSFIKGVVDSEDLPLNISREMLQQNKILKVVRKNIVKKCIELFDEIMEDKDNYKKFYEQFAKNIKLGIHEDSVNRNKLAEFLRYNSTSSGEEMISLKDYVSRMKENQKDIYYITGENKETVAKSAFVERLSKRGFEVLFMVDPIDEYSVQQLKEFDGKKLVCVTKEGLELPEDEEEKKKFEEQKAEFESLCKVMKDVLDKKVEKVTVSNRLVDSPCCVVTSQFGWSANMERIMKAQALRDSSTMGYMAAKKHLEINPDHSIMKSLKKRVDTDKNDKAVKDLINLLFETSLLTSGFSLEEPQVHGNRIHRMIKLGLGIDEEESVEEITEAVAD--LAPSAVEDEE-KMEEVD 707          

HSP 2 Score: 362.073 bits (928), Expect = 3.352e-114
Identity = 182/217 (83.87%), Postives = 207/217 (95.39%), Query Frame = 3
Query:   36 MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERD 686
            M ++ ++ETFAFQAEI+QL+SLIINTFYSNKEIFLRELISN+SDALDK+RYKSLTDPSVLD+ KEL+IK+IPDKD+ TLT+ DTG+GMTK++LINNLGTIARSGTKAFMEAL AGADISMIGQFGVGFYS+YLVAD+VQVI+K N+DEQY+WESSAGGSFTIK D SEP+GRG+KIIL MKEDQVEYL+E+KIKEIIKKHSQFIGYPIKLVLEKERD
Sbjct:    1 MSNIPEAETFAFQAEISQLMSLIINTFYSNKEIFLRELISNASDALDKVRYKSLTDPSVLDSQKELMIKVIPDKDSNTLTLYDTGVGMTKAELINNLGTIARSGTKAFMEALTAGADISMIGQFGVGFYSAYLVADRVQVITKSNEDEQYMWESSAGGSFTIKHDDSEPIGRGTKIILHMKEDQVEYLDEKKIKEIIKKHSQFIGYPIKLVLEKERD 217          
BLAST of Heat shock protein 90 vs. Planmine SMEST
Match: SMESG000054819.1 (SMESG000054819.1)

HSP 1 Score: 501.516 bits (1290), Expect = 9.843e-167
Identity = 302/681 (44.35%), Postives = 446/681 (65.49%), Query Frame = 3
Query:   54 SETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIRYKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTIARSGTKAFM----EALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQYLWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLXXXXXXXXXXXHSQFIGYPIKLVLEKERDKEVSDDXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXLNKTKPIWTRNPDDVSQEDYAEFYKSLTNDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRRVFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLVKKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHSTSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFEVLYMIDPIDEYSVQQLKEYDGKKLVCVTXXXXXXXXXXXXXXXXXXXXXXXXXLCKVMKDI-LDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQALRDSSTMG---YMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLYETSLLSSGFALEDPQIHANRIHRMIKLGL 2072
            +E + FQAE+ +++ LIIN+ Y NKEIFLRELISN+SDALDKIR+ SLT+       ++L IKI  DK A T+ I+DTG+GMTK++LI NLGTIA+SGT  F+    EA   G    +IGQFGVGFYSS+LVADKV VISK + D QY+WES A     ++      L RG+++IL +K++ +E+LE   ++ +I K+SQFI +PI   L K   K V +D     +K++E    E++ + +  +    D +                  +NK KPIWTR   +   E+Y EFYKS + D E+ LA  HF+ EG+++F+A+L+ PK++  +     KK +NIKLYV+RVFI D+ +D++P+YL+F+KG++DS+DLPLN+SRE LQQ+K+LKVI+K LV+K L++F+++ ED   +K+F++++A N+KLG+ ED  NRN+LA  +R+ S+ S E  TSL DY+SRMK  Q  I++I G S  +V  S  VE L K+ +EVLY+I+PIDEY+ Q L E++GKK   V KEG +L + +++ +  E+ +  +EPL   +K   L   +EKV +S RL +SPC ++ S +GWS NMERIMKAQA + S  +     +  KK LEIN  HS+++ LK      ++    + L   LY+T+LL SG+ +++    + ++H +IK  +
Sbjct:   93 AEKYTFQAEVDRMMKLIINSLYKNKEIFLRELISNASDALDKIRFISLTNQDRNFDNEDLYIKIKADKAAKTIHILDTGVGMTKTELIKNLGTIAKSGTSDFIQKLSEAKNTGELNELIGQFGVGFYSSFLVADKVTVISKSDADYQYIWESDASTFSIVRDPRGNTLERGTEVILHLKDEVLEFLEIDVLRNLIHKYSQFINFPI--YLWKSSVKNVDEDHESAVSKRDEDANVENENERKSTERTVWDWEL-----------------VNKNKPIWTRKSGETPDEEYNEFYKSFSKDSENPLAKTHFTAEGEVQFKAILYIPKKSNVEFNSVDKKNDNIKLYVKRVFITDDFDDIMPKYLSFMKGIIDSDDLPLNVSRETLQQHKLLKVIKKKLVRKTLDMFKKLPEDI--FKEFWKEYATNIKLGVIEDVSNRNRLAKLIRFWSSHSQESQTSLADYVSRMKPTQDKIFFIAGVSLSDVQLSPMVEILLKKQYEVLYLIEPIDEYTFQSLPEFEGKKFQNVAKEGFKLDDSDKKIEIKEKLEKEYEPLINWLKSTELKDYIEKVEISERLTTSPCVLIASTYGWSGNMERIMKAQAYQKSEEVMQTYQVNQKKILEINTQHSLIRHLKYSFSNGQDMNETRKLAKFLYDTALLRSGYIMDNVASFSKQVHEIIKTSM 752          
The following BLAST results are available for this feature:
BLAST of Heat shock protein 90 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
HSP90AA11.092e-10878.65heat shock protein 90 alpha family class A member ... [more]
HSP90AA16.926e-10778.65heat shock protein 90 alpha family class A member ... [more]
HSP90AB14.198e-10577.48heat shock protein 90 alpha family class B member ... [more]
HSP90AB14.198e-10577.48heat shock protein 90 alpha family class B member ... [more]
HSP90AB14.198e-10577.48heat shock protein 90 alpha family class B member ... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsp-901.483e-9577.36Heat shock protein 90 [Source:UniProtKB/Swiss-Pro... [more]
hsp-901.483e-9577.36Heat shock protein 90 [Source:UniProtKB/Swiss-Pro... [more]
hsp-901.483e-9577.36Heat shock protein 90 [Source:UniProtKB/Swiss-Pro... [more]
hsp-901.483e-9577.36Heat shock protein 90 [Source:UniProtKB/Swiss-Pro... [more]
enpl-11.729e-10445.15Endoplasmin homolog [Source:UniProtKB/Swiss-Prot;... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hsp830.000e+075.80gene:FBgn0001233 transcript:FBtr0332873[more]
Hsp830.000e+075.80gene:FBgn0001233 transcript:FBtr0073040[more]
Gp933.999e-10546.73gene:FBgn0039562 transcript:FBtr0085254[more]
Trap13.575e-4629.22gene:FBgn0026761 transcript:FBtr0086149[more]
Trap13.575e-4629.22gene:FBgn0026761 transcript:FBtr0336666[more]
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BLAST of Heat shock protein 90 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsp90aa1.18.804e-10677.30heat shock protein 90, alpha (cytosolic), class A ... [more]
hsp90aa1.18.804e-10677.30heat shock protein 90, alpha (cytosolic), class A ... [more]
hsp90ab13.621e-10478.30heat shock protein 90, alpha (cytosolic), class A ... [more]
hsp90ab13.621e-10478.30heat shock protein 90, alpha (cytosolic), class A ... [more]
hsp90aa1.22.868e-10777.43heat shock protein 90, alpha (cytosolic), class A ... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ccdc1730.000e+073.68coiled-coil domain containing 173 [Source:Xenbase;... [more]
ccdc1730.000e+074.02coiled-coil domain containing 173 [Source:Xenbase;... [more]
uck10.000e+072.78uridine-cytidine kinase 1 [Source:Xenbase;Acc:XB-G... [more]
ccdc1730.000e+072.95coiled-coil domain containing 173 [Source:Xenbase;... [more]
ccdc1730.000e+071.51coiled-coil domain containing 173 [Source:Xenbase;... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Hsp90aa13.480e-11078.20heat shock protein 90, alpha (cytosolic), class A ... [more]
Hsp90aa13.480e-11078.20heat shock protein 90, alpha (cytosolic), class A ... [more]
Hsp90ab12.622e-10577.48heat shock protein 90 alpha (cytosolic), class B m... [more]
Hsp90b11.099e-11948.43heat shock protein 90, beta (Grp94), member 1 [Sou... [more]
Hsp90aa12.059e-10182.87heat shock protein 90, alpha (cytosolic), class A ... [more]
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BLAST of Heat shock protein 90 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P30946|HS90A_RABIT0.000e+072.96Heat shock protein HSP 90-alpha OS=Oryctolagus cun... [more]
sp|P02828|HSP83_DROME0.000e+075.80Heat shock protein 83 OS=Drosophila melanogaster O... [more]
sp|P04809|HSP83_DROPS0.000e+075.52Heat shock protein 83 OS=Drosophila pseudoobscura ... [more]
sp|P06660|HSP85_TRYCR0.000e+065.97Heat shock-like 85 kDa protein OS=Trypanosoma cruz... [more]
sp|P54651|HSC90_DICDI0.000e+064.34Heat shock cognate 90 kDa protein OS=Dictyostelium... [more]
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BLAST of Heat shock protein 90 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
C0KTP70.000e+087.3990 kDa heat shock protein OS=Dugesia japonica OX=6... [more]
A0A3M7S7W00.000e+078.65Heat shock 83 OS=Brachionus plicatilis OX=10195 GN... [more]
A0A0M4HFL90.000e+079.86Heat shock protein 90 OS=Macrostomum lignano OX=28... [more]
A0A1C6ZXV80.000e+078.73HSP90 OS=Cotesia chilonis OX=89804 GN=hsp90 PE=2 S... [more]
A0A267DD200.000e+079.72HATPase_c domain-containing protein OS=Macrostomum... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsp90aa1.21.089e-10477.08Astyanax mexicanus heat shock protein HSP 90-alpha... [more]
hsp90aa1.21.089e-10477.08Astyanax mexicanus heat shock protein HSP 90-alpha... [more]
hsp90ab11.009e-10478.60heat shock protein 90 alpha family class B member ... [more]
hsp90aa1.21.334e-10777.53Astyanax mexicanus heat shock protein HSP 90-alpha... [more]
hsp90aa1.22.133e-10777.53Astyanax mexicanus heat shock protein HSP 90-alpha... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
ENSPMAT00000003399.11.604e-8376.70pep scaffold:Pmarinus_7.0:GL479675:6143:15195:1 ge... [more]
hsp90b11.458e-10444.07heat shock protein 90, beta (grp94), member 1 [Sou... [more]
hsp90ab12.340e-6365.57heat shock protein 90, alpha (cytosolic), class A ... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
HSP820.000e+063.46Hsp90 chaperone; redundant in function with Hsc82p... [more]
HSC820.000e+061.38Cytoplasmic chaperone of the Hsp90 family; plays a... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
HSP906.368e-10479.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO453442.157e-11248.79Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO456668.310e-4544.61Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Heat shock protein 90 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
hsp90ab10.000e+074.86heat shock protein 90 alpha family class B member ... [more]
hsp90ab10.000e+073.17heat shock protein 90 alpha family class B member ... [more]
hsp90aa1.29.211e-10678.88heat shock protein HSP 90-alpha [Source:NCBI gene;... [more]
hsp90aa1.28.293e-10678.65heat shock protein HSP 90-alpha [Source:NCBI gene;... [more]
hsp90aa1.28.120e-10678.43heat shock protein HSP 90-alpha [Source:NCBI gene;... [more]
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BLAST of Heat shock protein 90 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000024822.10.000e+0100.00SMESG000024822.1[more]
SMESG000071533.10.000e+090.34SMESG000071533.1[more]
SMESG000071531.16.376e-12793.72SMESG000071531.1[more]
SMESG000025598.13.352e-11486.00SMESG000025598.1[more]
SMESG000054819.19.843e-16744.35SMESG000054819.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020317 ID=SMED30020317|Name=Heat shock protein 90|organism=Schmidtea mediterranea sexual|type=transcript|length=2308bp
TTACTATATTGTGTTCATAATTTAATATCAATTTAATGGAATCAATGAAT
GACTCTGAAACGTTTGCTTTTCAAGCTGAAATCGCACAATTATTGAGTCT
TATAATCAATACTTTCTATTCTAACAAAGAAATATTTTTGCGTGAATTAA
TTTCAAATTCTAGCGATGCACTAGACAAAATTCGATATAAAAGTTTGACA
GATCCGTCAGTACTCGACACTGCAAAGGAGTTAATCATAAAAATTATCCC
AGATAAAGATGCTGGAACTCTTACAATAATTGACACTGGAATTGGGATGA
CAAAGTCCGATTTGATTAATAATTTGGGTACAATTGCAAGATCAGGAACA
AAGGCATTTATGGAAGCACTGCAAGCTGGAGCTGATATTTCGATGATTGG
ACAATTTGGTGTTGGATTCTATTCATCGTATCTGGTAGCAGACAAAGTTC
AAGTTATATCAAAAGGTAATGATGACGAGCAATATTTATGGGAGTCTTCA
GCTGGTGGTTCTTTTACTATTAAACCTGATACATCAGAACCGTTAGGTCG
AGGATCTAAAATTATTCTGTTCATGAAAGAGGATCAAGTTGAATATTTAG
AAGAGCGCAAAATCAAAGAAATAATAAAAAAACATTCACAATTTATTGGT
TATCCAATTAAGCTTGTTCTTGAAAAAGAGCGTGACAAAGAAGTTTCGGA
CGATGAAGCTGAAACTGAAACTAAGAAAGAGGAAAGCGAAGAAGGTGAGG
ACAAGCCGAAAATTGAAGATTTGGATGATGAGGAAGATGACGATAAGAAA
GACAAGAAAAAGAAAAAGAAGATCAAAGAGAAATACATTGACGAGGAAGA
GCTGAATAAAACTAAACCAATTTGGACACGAAATCCCGATGATGTTAGTC
AAGAAGATTATGCTGAATTTTATAAATCCTTAACAAATGATTGGGAGGAT
CATTTAGCTGTGAAACATTTCTCTGTTGAAGGTCAATTGGAATTCCGTGC
ATTGTTATTTTGTCCTAAAAGAGCTCCTTTTGATTTGTTTGAAAACAAAA
AGAAAAGAAATAATATAAAACTCTACGTCCGTAGAGTGTTTATAATGGAC
AACTGTGAAGACTTGATACCGGAATATTTGAATTTTGTTAAAGGAGTAGT
CGACAGCGAAGATCTGCCATTGAATATCAGTCGAGAGATGCTTCAACAGA
ACAAGATTTTAAAAGTAATTCGTAAAAACTTGGTGAAAAAATGCCTGGAA
TTATTTGAAGAGATTATGGAAGACAAAGATAATTACAAAAAGTTTTATGA
ACAGTTCGCAAAGAATTTGAAGTTGGGAATTCACGAAGACAGCGTAAATC
GTAACAAATTGGCTGACTTCCTGCGCTACCATTCAACTTCAAGCGGTGAA
GAAATGACAAGTTTGAAGGATTACTTATCGAGAATGAAAGAAAATCAAAA
GGATATTTATTATATTACTGGGGAAAGTAAAGACAATGTAGCTCATTCGG
CATTCGTTGAGAGACTTACAAAGCGCGGGTTTGAGGTTCTGTATATGATC
GATCCAATTGACGAATACAGCGTTCAACAACTCAAGGAATATGACGGTAA
AAAACTGGTCTGTGTAACTAAAGAGGGATTGGAATTGCCGGAAGATGAAG
AGGAAAAGAAAAAATTTGAAGAACAAAAAGCTGCTTTTGAACCTCTGTGC
AAAGTTATGAAGGATATATTAGACAAAAAAGTTGAGAAAGTGACAGTTTC
GAACCGTTTGGTGTCTTCTCCATGCTGTATTGTAACTTCTCAGTTCGGTT
GGTCTGCCAATATGGAACGTATAATGAAAGCACAAGCGTTAAGAGACAGC
AGCACAATGGGATATATGGCTGCTAAAAAGCATTTAGAAATTAATCCAGA
TCACTCAGTTATGAAAGCTCTTAAAACAAGAGTCGATGCGGATAAAAATG
ATAAATCAGTTAAAGATTTGGTCATGCTTCTTTATGAAACTTCTTTATTA
AGCTCGGGATTTGCATTGGAAGATCCGCAGATTCATGCTAATCGGATTCA
TAGGATGATAAAACTGGGCCTCGGAATTGACGAAGATGACATGGAAATCG
ATACAACTGAAGTTGGTGATGTCCCGGTCGGTCCTTCGGCAACGGAAGAT
GAAGCTGGGAAAATGGAAGAAGTTGATTAAAAGAACTTTTTATTGTGTTG
TGTAAATATAATTTTTTATAGGATTATTTTGTAATAGGGTTATGAAGCAA
ATTAATTTTAATTTAATATCTTTTAATATGATATTTCTTTGCGTTATTTG
TATTTCCC
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protein sequence of SMED30020317-orf-1

>SMED30020317-orf-1 ID=SMED30020317-orf-1|Name=SMED30020317-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=715bp
MESMNDSETFAFQAEIAQLLSLIINTFYSNKEIFLRELISNSSDALDKIR
YKSLTDPSVLDTAKELIIKIIPDKDAGTLTIIDTGIGMTKSDLINNLGTI
ARSGTKAFMEALQAGADISMIGQFGVGFYSSYLVADKVQVISKGNDDEQY
LWESSAGGSFTIKPDTSEPLGRGSKIILFMKEDQVEYLEERKIKEIIKKH
SQFIGYPIKLVLEKERDKEVSDDEAETETKKEESEEGEDKPKIEDLDDEE
DDDKKDKKKKKKIKEKYIDEEELNKTKPIWTRNPDDVSQEDYAEFYKSLT
NDWEDHLAVKHFSVEGQLEFRALLFCPKRAPFDLFENKKKRNNIKLYVRR
VFIMDNCEDLIPEYLNFVKGVVDSEDLPLNISREMLQQNKILKVIRKNLV
KKCLELFEEIMEDKDNYKKFYEQFAKNLKLGIHEDSVNRNKLADFLRYHS
TSSGEEMTSLKDYLSRMKENQKDIYYITGESKDNVAHSAFVERLTKRGFE
VLYMIDPIDEYSVQQLKEYDGKKLVCVTKEGLELPEDEEEKKKFEEQKAA
FEPLCKVMKDILDKKVEKVTVSNRLVSSPCCIVTSQFGWSANMERIMKAQ
ALRDSSTMGYMAAKKHLEINPDHSVMKALKTRVDADKNDKSVKDLVMLLY
ETSLLSSGFALEDPQIHANRIHRMIKLGLGIDEDDMEIDTTEVGDVPVGP
SATEDEAGKMEEVD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000028Category 2 cell
PLANA:0000035Category 3 cell
PLANA:0000043dorsal ventral margin of the whole animal
PLANA:0000070intestinal phagocyte
PLANA:0000099neuron
PLANA:0000120progenitor cell
PLANA:0000418head
PLANA:0002032epidermal cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036890HATPase_C_sf
IPR037196HSP90_C
IPR020575Hsp90_N
IPR003594HATPase_C
IPR001404Hsp90_fam
IPR019805Heat_shock_protein_90_CS
IPR020568Ribosomal_S5_D2-typ_fold
Vocabulary: molecular function
TermDefinition
GO:0005524ATP binding
GO:0051082unfolded protein binding
GO:0000166nucleotide binding
GO:0016887ATPase activity
Vocabulary: biological process
TermDefinition
GO:0006457protein folding
GO:0006950response to stress
GO:0009408response to heat
GO:0009409response to cold
GO:0046677response to antibiotic
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005886plasma membrane
GO:0016020membrane
GO:0042470melanosome
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR020575Heat shock protein Hsp90, N-terminalPRINTSPR00775HEATSHOCK90coord: 190..208
score: 63.56
coord: 78..95
score: 72.48
coord: 121..143
score: 80.13
coord: 8..28
score: 76.48
coord: 172..189
score: 58.03
coord: 96..113
score: 81.45
coord: 29..51
score: 90.64
IPR003594Histidine kinase/HSP90-like ATPaseSMARTSM00387HKATPase_4coord: 30..168
e-value: 1.5E-7
score: 41.1
IPR003594Histidine kinase/HSP90-like ATPasePFAMPF02518HATPase_ccoord: 30..183
e-value: 1.2E-13
score: 51.6
IPR036890Histidine kinase/HSP90-like ATPase superfamilyGENE3DG3DSA:3.30.565.10coord: 8..212
e-value: 4.3E-102
score: 342.7
IPR036890Histidine kinase/HSP90-like ATPase superfamilySUPERFAMILYSSF55874ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinasecoord: 8..215
NoneNo IPR availableGENE3DG3DSA:3.30.70.2140coord: 213..262
e-value: 4.3E-102
score: 342.7
NoneNo IPR availableGENE3DG3DSA:3.30.230.80coord: 274..447
e-value: 3.6E-81
score: 273.0
NoneNo IPR availableGENE3DG3DSA:3.40.50.11260coord: 448..530
e-value: 6.5E-37
score: 127.2
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 217..257
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 695..714
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 217..238
NoneNo IPR availablePANTHERPTHR11528:SF52HEAT SHOCK PROTEIN HSP 90-ALPHA 1coord: 6..714
NoneNo IPR availableCDDcd16927HATPase_Hsp90-likecoord: 18..204
e-value: 3.47399E-108
score: 324.474
IPR001404Heat shock protein Hsp90 familyPFAMPF00183HSP90coord: 186..691
e-value: 2.3E-234
score: 779.1
IPR001404Heat shock protein Hsp90 familyPIRSFPIRSF002583HSP90_HTPGcoord: 1..714
e-value: 4.1E-251
score: 833.1
IPR001404Heat shock protein Hsp90 familyPANTHERPTHR11528HEAT SHOCK PROTEIN 90 FAMILY MEMBERcoord: 6..714
IPR037196HSP90, C-terminal domainGENE3DG3DSA:1.20.120.790coord: 531..679
e-value: 1.3E-67
score: 228.2
IPR037196HSP90, C-terminal domainSUPERFAMILYSSF110942HSP90 C-terminal domaincoord: 553..675
IPR019805Heat shock protein Hsp90, conserved sitePROSITEPS00298HSP90coord: 28..37
IPR020568Ribosomal protein S5 domain 2-type foldSUPERFAMILYSSF54211Ribosomal protein S5 domain 2-likecoord: 275..530