Regulator of G-protein signaling 3

Overview
NameRegulator of G-protein signaling 3
Smed IDSMED30020254
Length (bp)1582
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Regulator of G-protein signaling 3 (SMED30020254) t-SNE clustered cells

Violin plots show distribution of expression levels for Regulator of G-protein signaling 3 (SMED30020254) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Regulator of G-protein signaling 3 (SMED30020254) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Regulator of G-protein signaling 3 (SMED30020254) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020254

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30020254h1SMcG0015157 Contig3389newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020254h1SMcG0015157 Contig3389uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020254h1SMcG0017479 Contig3389newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020254h1SMcG0017479 Contig3389uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
nervous systemSMED30020254h1SMcG0017479 dd_Smed_v4_12613_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30020254h1SMcG0017479 dd_Smed_v4_12613_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30020254h1SMcG0017479 dd_Smed_v4_12613_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30020254h1SMcG0017479 dd_Smed_v4_12613_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30020254h1SMcG0017479 dd_Smed_v4_12613_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Human
Match: RGS3 (regulator of G protein signaling 3 [Source:HGNC Symbol;Acc:HGNC:9999])

HSP 1 Score: 70.4774 bits (171), Expect = 3.169e-12
Identity = 42/160 (26.25%), Postives = 78/160 (48.75%), Query Frame = 3 
Query:  429 NQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDA-TLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
             +R++++ +          ++G MSFG+K +   +  ++GWYYLL E++G  KHLKV +  +       +      D    + +K+ + R  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  103 QKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 262
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Human
Match: RGS3 (regulator of G protein signaling 3 [Source:HGNC Symbol;Acc:HGNC:9999])

HSP 1 Score: 70.8626 bits (172), Expect = 3.746e-12
Identity = 57/258 (22.09%), Postives = 111/258 (43.02%), Query Frame = 3 
Query:  135 DKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDA-TLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
            D+ T+   + K   H      G+L L +   ++  L +HII  +   +      + ++KI+        +           D +F    +    +    +R++++ +          ++G MSFG+K +   +  ++GWYYLL E++G  KHLKV +  +       +      D    + +K+ + R  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  118 DEWTQTSPARKRITHAKVQGAGQLRLSIDAQDR-VLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 374
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Human
Match: RGS3 (regulator of G protein signaling 3 [Source:HGNC Symbol;Acc:HGNC:9999])

HSP 1 Score: 70.8626 bits (172), Expect = 3.746e-12
Identity = 57/258 (22.09%), Postives = 111/258 (43.02%), Query Frame = 3 
Query:  135 DKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDA-TLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
            D+ T+   + K   H      G+L L +   ++  L +HII  +   +      + ++KI+        +           D +F    +    +    +R++++ +          ++G MSFG+K +   +  ++GWYYLL E++G  KHLKV +  +       +      D    + +K+ + R  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  118 DEWTQTSPARKRITHAKVQGAGQLRLSIDAQDR-VLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 374
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Zebrafish
Match: rgs3b (regulator of G protein signaling 3b [Source:ZFIN;Acc:ZDB-GENE-060531-24])

HSP 1 Score: 61.2326 bits (147), Expect = 2.020e-9
Identity = 44/165 (26.67%), Postives = 80/165 (48.48%), Query Frame = 3 
Query:  426 MNQRIIISAYVMDGTNVM--ILGSMSFGIKK-IWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITA----DVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRS 899
              +R++++ +  D  +     LG MSFG+   I  S+ + GWYYLL E +G  KHLKV    I ++  A    +    ++    ++   V + R  + FGFTIC + P  V  V+    A    L+  D ++++    V       +A  +R   +E+++ ++R+
Sbjct:   64 QKKRLLVTVWNRDRDSRRSDFLGCMSFGVHSLITSSKEIRGWYYLLGEELGRSKHLKVASRRIRQTAAAAPNYEAGPESSGPENMQSFTVTILRGKDGFGFTICSDSPVRVQAVDPGGPAHQAGLQQLDTLLQLNGQPVEHWKCVDLAHAIRNCRNEITVVVWRT 228
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Mouse
Match: Rgs3 (regulator of G-protein signaling 3 [Source:MGI Symbol;Acc:MGI:1354734])

HSP 1 Score: 74.3294 bits (181), Expect = 1.693e-13
Identity = 43/162 (26.54%), Postives = 82/162 (50.62%), Query Frame = 3 
Query:  429 NQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLE---LIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
             +R++++ +    +     ++G MSFG++ +   +  ++GWYYLL E++G  KHLKV +  +      D+L     +   E    +++ +RR  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  111 QKRLLVTVWNRASETRQHTLIGCMSFGVRSLLTPDKEISGWYYLLGEDLGRTKHLKVARRRL--QPLRDMLLRMPGEGDPENGEKLQITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 270
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Mouse
Match: Rgs3 (regulator of G-protein signaling 3 [Source:MGI Symbol;Acc:MGI:1354734])

HSP 1 Score: 74.3294 bits (181), Expect = 1.703e-13
Identity = 43/162 (26.54%), Postives = 82/162 (50.62%), Query Frame = 3 
Query:  429 NQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLE---LIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
             +R++++ +    +     ++G MSFG++ +   +  ++GWYYLL E++G  KHLKV +  +      D+L     +   E    +++ +RR  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  103 QKRLLVTVWNRASETRQHTLIGCMSFGVRSLLTPDKEISGWYYLLGEDLGRTKHLKVARRRL--QPLRDMLLRMPGEGDPENGEKLQITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 262
[Close]
BLAST of Regulator of G-protein signaling 3 vs. UniProt/SwissProt
Match: sp|P49796|RGS3_HUMAN (Regulator of G-protein signaling 3 OS=Homo sapiens OX=9606 GN=RGS3 PE=1 SV=2)

HSP 1 Score: 70.8626 bits (172), Expect = 1.799e-11
Identity = 57/258 (22.09%), Postives = 111/258 (43.02%), Query Frame = 3 
Query:  135 DKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAY--VMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDA-TLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYR 896
            D+ T+   + K   H      G+L L +   ++  L +HII  +   +      + ++KI+        +           D +F    +    +    +R++++ +          ++G MSFG+K +   +  ++GWYYLL E++G  KHLKV +  +       +      D    + +K+ + R  + FGFTIC + P  V  V+    A+   L+  D ++++    V       +A  +R  P E+ L ++R
Sbjct:  118 DEWTQTSPARKRITHAKVQGAGQLRLSIDAQDR-VLLLHIIEGKGLISKQPGTCDPYVKISLIPEDSRLRHQKTQTVPDCRDPAFHEHFFFPVQEEDDQKRLLVTVWNRASQSRQSGLIGCMSFGVKSLLTPDKEISGWYYLLGEHLGRTKHLKVARRRLRPLRDPLLRMPGGGDTENGKKLKITIPRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWR 374
[Close]
BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Match: A0A1S3IK27 (regulator of G-protein signaling 3-like OS=Lingula unguis OX=7574 GN=LOC106164761 PE=4 SV=1)

HSP 1 Score: 98.9821 bits (245), Expect = 1.412e-18
Identity = 84/284 (29.58%), Postives = 145/284 (51.06%), Query Frame = 3 
Query:  132 IDKVTKP---------VKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQ--RIIISAYVMDGTNVMILGSMSFGIKKIWESEM-LTGWYYLLKENIGSKKHLK-----------VYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPS 914
            +D++ +P         V S K +  V    KG++ L + + N   L +H+++A+       +   +++K+       EK+ +    +I     + +YD    F  L  +Q  R+I+S +    T   +LG MSFGIKK+ +S+  + GWY+LL E IG +KHLK            YQ  IP+ + +DVL        +E + V LRR    FGFT+ G+ P  VG+VE++S A    LR+GD IV+I    V   +A+++ +++R   +++ + + R +  P+
Sbjct:    4 VDEIERPYLELVERDMVWSGKENQPVYQLYKGKVKLSVYM-NCGLLTIHVVQAKNLFMVGNKLCNSYLKLCLVPD--EKKRTQCKTKIIRGTNNPKYDQRFSFEILPEDQDKRLILSVWHRRKTESELLGCMSFGIKKLVKSKKEIGGWYFLLSEEIGRQKHLKFTPGICKVQTKAYQH-IPK-VHSDVLW-------MESLTVCLRRGERGFGFTVVGSCPVRVGRVEQSSEAWSSGLRTGDYIVQINSQNVSRSTAESVVRLVRHSSNQIIVDVQRPRRVPT 275
[Close]
BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Match: R7UMU1 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_223275 PE=4 SV=1)

HSP 1 Score: 97.4413 bits (241), Expect = 1.752e-17
Identity = 73/270 (27.04%), Postives = 138/270 (51.11%), Query Frame = 3 
Query:  192 CKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPS-ETFIKINFTSSSVEKQMSPLAKRISNTDF--SFRYDGYCLFNKLHMN--QRIIISAYVMDGTN--VMILGSMSFGIK----KIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDA-TLELIKVDLRRKGNEFGFTI-CGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPK 962
            C G+L L  +  +Q  L+V +++A   +      S  TF +++     +    +   +  +N  F  SF Y+     + + +N  +R+ +     D  +  + ILGS SFG++    +I   +   GWYYLL E++G+KKHL+V   + P  +++  L T   DA  L  +K++++ + + +GF++  G+ P  +  +    +A DC L+SGDVI+ I+   V    ++++A+++R    +V L I R     S   L ++ V   +SP+
Sbjct:   73 CTGQLQLRFAA-SQRGLRVCVLQARHIRLPGSASSCNTFAQLSIADEPLSFCCTAEVRGSNNPVFKQSFTYN----IDHVQLNGHRRLTLRLCNRDANSGRIDILGSTSFGLRHLLSRIRRQDKQDGWYYLLNESLGAKKHLRVLSTSKPAPVSSADLSTVNLDARNLPTLKINIKERKDGYGFSLKSGSCPVRISTIRPGGSAQDCGLQSGDVILAIQGRNVSRSCSRSVAELIRQLGGDVQLEIGRPSFSTSTLSLQIDDVIPEQSPE 337
[Close]
BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Match: K1QCA8 (Regulator of G-protein signaling 3 OS=Crassostrea gigas OX=29159 GN=CGI_10009646 PE=4 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 2.321e-15
Identity = 72/264 (27.27%), Postives = 125/264 (47.35%), Query Frame = 3 
Query:  135 DKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHM--NQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLT-GWYYLLKENIGSKKHLKVYQETIP----RSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKT 905
            DK T+P+K        +   +G++ L   + N   L VH+I+A    + F       +K++       K  S     + N   +  +D    F  L    N+R++IS +  +  N   LG  SFGI+ +      T GWYYLL E +G KKHLK+  +  P    R+   +V   N     +E + V + R  + +GF++  + P  VG+V++ S AD   L  GD I+++ +  V    + ++A++++     +++ I RSK 
Sbjct:  210 DKKTRPLK--------VLQNEGQIRLSAYM-NFGLLTVHVIQARHLTSKFSPLCNAIVKMSLVPDETRK--SRCRTEVVNGSNNPLFDEKFSFELLEEDNNKRLLISVWNKESGNSEFLGCTSFGIRHLINPRKDTDGWYYLLTEEVGRKKHLKLSSKNQPKLQVRNQRENVPPINKDIWGMESLTVTVHRGEHGYGFSVVESCPVKVGRVDRGSPADHAGLCPGDCIIRVNNQNVSRSQSASVAKLVKSAGPTLTIDIQRSKA 462
[Close]
BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Match: R7UMS9 (Uncharacterized protein OS=Capitella teleta OX=283909 GN=CAPTEDRAFT_223263 PE=4 SV=1)

HSP 1 Score: 88.1965 bits (217), Expect = 1.213e-14
Identity = 73/265 (27.55%), Postives = 127/265 (47.92%), Query Frame = 3 
Query:  180 VLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLH--MNQRIIISAYVMDG--TNVMILGSMSFGIKKIW-ESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLC--------TNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSK-----TQPSNC 920
            +L   KG L + + V N   L VH+I  +  K+   + S+T+IK++     + +     A   S  +    YD    F  L   MN+R++IS +  D        LG MSFG+  I  + + + GWYYLL   IG +KHL+V +         +V           +  +   +++ + +R+    +GF++ G  P  V +V+  SAA+   L   D I++I+   V   S++++A+I+R    +V+L + R K     T P++C
Sbjct:  148 MLQAYKGELKINVYV-NYGLLTVHLIEGKQLKSQMSDLSDTYIKVSLMPDELRRTKCKTAVVYSTNNP--HYDEKFSFELLDEDMNKRLLISVWHRDSHHNQCEFLGCMSFGLLAIQSQRKSVQGWYYLLSGEIGKRKHLQVSENEPDYKSGVEVFLIIPAGNKMAHVKEEMHDVLTIVVRKPKGGYGFSLTGACPVKVARVDYLSAAEVAGLHKDDCIMRIDGQNVSRSSSESVARIIRHADRKVTLEVQRLKLHVETTFPASC 409
[Close]
BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Match: A0A1S3H826 (uncharacterized protein LOC106153048 OS=Lingula unguis OX=7574 GN=LOC106153048 PE=4 SV=1)

HSP 1 Score: 88.1965 bits (217), Expect = 1.393e-14
Identity = 56/153 (36.60%), Postives = 88/153 (57.52%), Query Frame = 3 
Query:  492 MSFGIKKIWESEM-LTGWYYLLKENIGSKKHLK-----------VYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPS 914
            MSFGIKK+ +S+  + GWY+LL E IG +KHLK            YQ  IP+ + +DVL        +E + V LRR    FGFT+ G+ P  VG+VE++S A    LR+GD IV+I    V   +A+++ +++R   +++ + + R +  P+
Sbjct:    1 MSFGIKKLVKSKKEIGGWYFLLSEEIGRQKHLKFTPGICKVQTKAYQH-IPK-VHSDVLW-------MESLTVCLRRGERGFGFTVVGSCPVRVGRVEQSSEAWSSGLRTGDYIVQINSQNVSRSTAESVVRLVRHSSNQIIVDVQRPRRVPT 144
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Cavefish
Match: rgs3b (regulator of G-protein signaling 3 [Source:NCBI gene;Acc:103021936])

HSP 1 Score: 63.5438 bits (153), Expect = 3.495e-10
Identity = 63/247 (25.51%), Postives = 116/247 (46.96%), Query Frame = 3 
Query:  195 KGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSS--SVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMI--LGSMSFGIKK-IWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATL-------ELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRS 899
            KG+L L ++ +N+  L V I+ A         P ++++KI+        ++Q +       N  F+  +       +LH  +R++++A+    T+  I  LG MSFG++  I  ++ + GWYYLL E +G  KHL+V    I +S  A  L  +             + + V + R  + FGFTIC + P  V  V+    A    L+  D ++++    V       +A  +R   +E+++ ++R+
Sbjct:  138 KGQLKLIVTPYNR-LLCVQILEARGLLGKEYRPCDSYVKISLVPEVDHSKRQRTRTVLDCKNPVFNETFAISVGEEELH--KRLLVTAWNRSRTSRRIDFLGCMSFGVQSLISSAKEIRGWYYLLGEELGRSKHLRVASRRIKQSAEA-ALSNHAAGPEFAAQPENTQSLTVTILRGKDGFGFTICSDSPVRVQAVDPGGPAHQAGLQQLDTLLQLNGQPVEHWKCVDLAHAIRNCRNEITVVVWRT 380
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Cavefish
Match: rgs3b (regulator of G-protein signaling 3 [Source:NCBI gene;Acc:103021936])

HSP 1 Score: 63.1586 bits (152), Expect = 5.237e-10
Identity = 46/169 (27.22%), Postives = 84/169 (49.70%), Query Frame = 3 
Query:  423 HMNQRIIISAYVMDGTNVMI--LGSMSFGIKK-IWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATL-------ELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRS 899
             +++R++++A+    T+  I  LG MSFG++  I  ++ + GWYYLL E +G  KHL+V    I +S  A  L  +             + + V + R  + FGFTIC + P  V  V+    A    L+  D ++++    V       +A  +R   +E+++ ++R+
Sbjct:  103 ELHKRLLVTAWNRSRTSRRIDFLGCMSFGVQSLISSAKEIRGWYYLLGEELGRSKHLRVASRRIKQSAEA-ALSNHAAGPEFAAQPENTQSLTVTILRGKDGFGFTICSDSPVRVQAVDPGGPAHQAGLQQLDTLLQLNGQPVEHWKCVDLAHAIRNCRNEITVVVWRT 270
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Sea Lamprey
Match: sntg2 (syntrophin, gamma 2 [Source:ZFIN;Acc:ZDB-GENE-060526-196])

HSP 1 Score: 50.8322 bits (120), Expect = 4.878e-7
Identity = 33/102 (32.35%), Postives = 53/102 (51.96%), Query Frame = 3 
Query:  624 DVLCTNTTDATLELIKVDLRRKGNEFGFTICG----NQPPYVGKVEKNSAADDCN-LRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPS 914
            DV+C   +  + E      R++   FG +I G    N P  + K+ K+ AAD    L  GD I+++  + V SC+ + + +ILR   DEV+LT+   K  P+
Sbjct:   37 DVVCVGGSSVSNERTVTLCRQRVGGFGLSIKGGAEHNVPVVISKIFKDQAADQTGMLFVGDAILQVNGINVVSCTHEELVRILRNAGDEVTLTVGYLKEAPA 138
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Medaka
Match: ENSORLT00000021998.2 (regulator of G-protein signaling 3 [Source:NCBI gene;Acc:101174109])

HSP 1 Score: 51.6026 bits (122), Expect = 1.805e-6
Identity = 37/137 (27.01%), Postives = 65/137 (47.45%), Query Frame = 3 
Query:  195 KGRLLLEMSVHNQS-TLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAK-RISNTDFSFRYD---GYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKV 590
            +GR  L++SV  ++  L +H+  A           ++++K++ TS   ++  S   K R    + + +YD     C+  KL     + +   + D     ++G MSF I  +     LT W+YLL E+ G  KHL+V
Sbjct:  213 RGRGQLKLSVTPEAGQLAIHVHEARGLMEKSHRSCDSYVKVSVTS---DRHNSVWMKTRTVPNEKNPKYDQSVSLCVRGKLQSRLLVSVCRRLHDCRGSQLIGCMSFSIGSLVSRSQLTDWFYLLNEDFGRSKHLRV 346

HSP 2 Score: 51.6026 bits (122), Expect = 1.917e-6
Identity = 27/92 (29.35%), Postives = 47/92 (51.09%), Query Frame = 3 
Query:  666 IKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQP-SNCDLFVNS 938
            ++V + R  + FGFTIC + P  V  V+    A    LR GD ++++  L V +     +A  +R  P +++L ++R   +  S CD  + S
Sbjct:  434 LRVSILRGEDGFGFTICSDSPVKVQAVDPGGPAHLSGLRQGDSVMQLNGLPVETWKCVDLAHAIRSCPSQITLVVWRGLPEAGSGCDALLRS 525
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Planmine SMEST
Match: SMESG000057434.1 (SMESG000057434.1)

HSP 1 Score: 974.156 bits (2517), Expect = 0.000e+0
Identity = 500/501 (99.80%), Postives = 500/501 (99.80%), Query Frame = 3 
Query:   66 MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVXXXXXXXXXXXXXXXXXXXXXXXXXXEENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEISTT 1568
            MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVIKFHSKSKSISWIKKIMTTKKKINK EENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEISTT
Sbjct:    1 MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVIKFHSKSKSISWIKKIMTTKKKINKFEENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEISTT 501
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BLAST of Regulator of G-protein signaling 3 vs. Planmine SMEST
Match: SMESG000057434.1 (SMESG000057434.1)

HSP 1 Score: 969.148 bits (2504), Expect = 0.000e+0
Identity = 497/499 (99.60%), Postives = 498/499 (99.80%), Query Frame = 3 
Query:   66 MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVXXXXXXXXXXXXXXXXXXXXXXXXXXEENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEIS 1562
            MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVIKFHSKSKSISWIKKIMTTKKKINK EENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEI+
Sbjct:    1 MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKRISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKDVIKFHSKSKSISWIKKIMTTKKKINKFEENFPQNYYVSNLGCKMNECHIDGNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYITNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLSMPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEIN 499
[Close]
BLAST of Regulator of G-protein signaling 3 vs. Planmine SMEST
Match: SMESG000022937.1 (SMESG000022937.1)

HSP 1 Score: 132.88 bits (333), Expect = 8.759e-33
Identity = 102/314 (32.48%), Postives = 158/314 (50.32%), Query Frame = 3 
Query:    3 PIKLSLNSTAII*IRMLGN*KMSTRCRSLYVDKDVSESSNYCDIDKVTK-PVKSHKTSFHVLAPCKGRLLLEMSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPL-AKRISNTDFSFRYDGYCLFN--KLHMNQRIIISAYVMDGTNVMILGSMSFGIKKIWESEMLTGWYYLLKENIGSKKHLKV------YQETIPRSITADVLCTNTTDATL--ELIKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHLLVFSCSAKAIAQILRLYPDEVSLTIYRSKTQ 908
            PI+ S N+T +I              RSL  D+    +S   D    TK P+K     F  LAPCKGR+ L + +   S + + +  A+  ++     S  F++I   S+    Q  PL    +   + S  +D    FN   L   +RI+IS Y +    +  LG MSFGIKK      ++GWYYLLKE IG +KHLK          ++  S+  D   TN T++ +  ++I+V L +    FGFT+CG  P YV  V+ +S+A+   +  GD+I+KI++  V   S +A+ ++ R+ P  V +T++RS  Q
Sbjct:  199 PIRNSTNNTQLI-------------SRSLSPDESYLRNS---DSKSETKFPIKPE---FTTLAPCKGRINLTI-LCQFSRITILLKEADNLRSMNNSVSNPFVRIQLLSNLPNGQNIPLFDSEVFPNNSSPVFDKSFSFNISPLDYYKRIVISTYHVQNNELESLGCMSFGIKKFQIKTQVSGWYYLLKEEIGYRKHLKAGFLSVNKTNSVSNSVLQDSKLTNLTNSNVGYQIIEVKLVKGLRGFGFTLCGGSPVYVSHVDVDSSAELAGIHPGDMIIKIDNFNVSQSSTEAVVRMFRMCPKSVKVTLWRSPPQ 492
The following BLAST results are available for this feature:
BLAST of Regulator of G-protein signaling 3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
RGS33.169e-1226.25regulator of G protein signaling 3 [Source:HGNC Sy... [more]
RGS33.746e-1222.09regulator of G protein signaling 3 [Source:HGNC Sy... [more]
RGS33.746e-1222.09regulator of G protein signaling 3 [Source:HGNC Sy... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
rgs3b2.020e-926.67regulator of G protein signaling 3b [Source:ZFIN;A... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Rgs31.693e-1326.54regulator of G-protein signaling 3 [Source:MGI Sym... [more]
Rgs31.703e-1326.54regulator of G-protein signaling 3 [Source:MGI Sym... [more]
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BLAST of Regulator of G-protein signaling 3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1
Match NameE-valueIdentityDescription
sp|P49796|RGS3_HUMAN1.799e-1122.09Regulator of G-protein signaling 3 OS=Homo sapiens... [more]
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BLAST of Regulator of G-protein signaling 3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1S3IK271.412e-1829.58regulator of G-protein signaling 3-like OS=Lingula... [more]
R7UMU11.752e-1727.04Uncharacterized protein OS=Capitella teleta OX=283... [more]
K1QCA82.321e-1527.27Regulator of G-protein signaling 3 OS=Crassostrea ... [more]
R7UMS91.213e-1427.55Uncharacterized protein OS=Capitella teleta OX=283... [more]
A0A1S3H8261.393e-1436.60uncharacterized protein LOC106153048 OS=Lingula un... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
rgs3b3.495e-1025.51regulator of G-protein signaling 3 [Source:NCBI ge... [more]
rgs3b5.237e-1027.22regulator of G-protein signaling 3 [Source:NCBI ge... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
sntg24.878e-732.35syntrophin, gamma 2 [Source:ZFIN;Acc:ZDB-GENE-0605... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Regulator of G-protein signaling 3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSORLT00000021998.21.805e-627.01regulator of G-protein signaling 3 [Source:NCBI ge... [more]
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BLAST of Regulator of G-protein signaling 3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000057434.10.000e+099.80SMESG000057434.1[more]
SMESG000057434.10.000e+099.60SMESG000057434.1[more]
SMESG000022937.18.759e-3332.48SMESG000022937.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020254 ID=SMED30020254|Name=Regulator of G-protein signaling 3|organism=Schmidtea mediterranea sexual|type=transcript|length=1582bp
ATCCAATCAAATTATCGTTGAATTCCACTGCTATTATTTGAATTCGGATG
CTTGGCAATTAGAAAATGTCGACCAGGTGCAGATCATTATATGTCGATAA
GGATGTTTCAGAATCTTCCAATTACTGCGACATCGACAAAGTCACTAAAC
CAGTCAAATCTCATAAAACATCCTTCCATGTTCTGGCACCTTGTAAAGGC
CGCCTCCTGCTCGAGATGTCGGTGCATAATCAGTCAACGTTGAAAGTTCA
CATAATACGAGCAGAATTTCCTAAGACAAGCTTCAAAGAACCTTCAGAAA
CTTTTATTAAAATTAATTTCACTTCTTCCAGCGTCGAAAAGCAAATGTCT
CCTTTGGCAAAGCGAATATCAAACACCGATTTTTCATTCCGATATGACGG
GTACTGTTTATTCAACAAGCTGCACATGAATCAAAGAATCATAATCTCGG
CATATGTGATGGATGGGACGAATGTGATGATACTTGGTTCAATGTCTTTT
GGAATTAAAAAAATTTGGGAATCAGAAATGCTAACAGGTTGGTACTATCT
ATTGAAAGAAAACATAGGATCTAAAAAGCATTTGAAGGTCTACCAGGAAA
CCATTCCTCGTAGCATAACGGCTGATGTTTTATGCACTAATACTACCGAT
GCAACCTTGGAACTTATTAAAGTCGATCTCAGGAGAAAGGGCAATGAATT
TGGATTTACAATATGCGGGAACCAACCTCCTTATGTTGGAAAAGTAGAAA
AGAATTCAGCTGCTGACGATTGTAACTTGAGGTCAGGAGATGTTATTGTA
AAAATTGAACATCTATTAGTGTTTTCTTGCTCGGCTAAGGCAATAGCTCA
AATACTTAGATTATATCCAGACGAAGTCAGCCTGACAATATATCGTTCAA
AGACTCAACCGTCAAATTGTGATTTGTTCGTCAATTCAGTGGGTAGCCCG
AAATCCCCAAAAGATGTTATCAAATTCCACTCGAAATCGAAATCCATATC
TTGGATAAAAAAAATTATGACAACGAAAAAGAAAATTAACAAGTCCGAAG
AGAATTTCCCTCAAAATTATTATGTATCCAATTTGGGATGTAAAATGAAT
GAGTGTCACATTGACGGTAATTTAAACAAAAACCCAGTCTCCTCCCCTGA
CATTGAAATTGTTAAGGATAATAATAAAAATAATGTTATCGACAGGTTGC
AATATCTTGGTAACATTCAGTCGGTAAAATTCCCGCCAAATCACGGTGCT
CATGTAGAATACATTACAAATTTGTGGCTGATTGAGACAACCAGTAGGAT
CAGCGTCACGGTTTTGCTATTGAGCCACCTGATACTAATTACCCATGTTG
AACCTGATGGGTTTTATACTGTCATAAAACGGCCAATTTTGATTGAAAGC
ATTATGTATTTATCTATGCCAATCTCTACAACATATGATCTTGTGCTACA
ATATCGGGGCGAAGGGGGAGCCAATGAAACGATTCATTTACACGGGGATT
CCGTTGAATATTTCACAAATCTTTTGAAAGAGAAACGAGTCACACACAAC
ACCGAAATCAGTACGACTTAAACAATTTTTCT
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protein sequence of SMED30020254-orf-1

>SMED30020254-orf-1 ID=SMED30020254-orf-1|Name=SMED30020254-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=502bp
MSTRCRSLYVDKDVSESSNYCDIDKVTKPVKSHKTSFHVLAPCKGRLLLE
MSVHNQSTLKVHIIRAEFPKTSFKEPSETFIKINFTSSSVEKQMSPLAKR
ISNTDFSFRYDGYCLFNKLHMNQRIIISAYVMDGTNVMILGSMSFGIKKI
WESEMLTGWYYLLKENIGSKKHLKVYQETIPRSITADVLCTNTTDATLEL
IKVDLRRKGNEFGFTICGNQPPYVGKVEKNSAADDCNLRSGDVIVKIEHL
LVFSCSAKAIAQILRLYPDEVSLTIYRSKTQPSNCDLFVNSVGSPKSPKD
VIKFHSKSKSISWIKKIMTTKKKINKSEENFPQNYYVSNLGCKMNECHID
GNLNKNPVSSPDIEIVKDNNKNNVIDRLQYLGNIQSVKFPPNHGAHVEYI
TNLWLIETTSRISVTVLLLSHLILITHVEPDGFYTVIKRPILIESIMYLS
MPISTTYDLVLQYRGEGGANETIHLHGDSVEYFTNLLKEKRVTHNTEIST
T*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005515protein binding
GO:0005089Rho guanyl-nucleotide exchange factor activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
Vocabulary: INTERPRO
TermDefinition
IPR035892C2_domain_sf
IPR036034PDZ_sf
IPR001478PDZ
Vocabulary: biological process
TermDefinition
GO:0035023regulation of Rho protein signal transduction
GO:0043547positive regulation of GTPase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001478PDZ domainSMARTSM00228pdz_newcoord: 210..279
e-value: 4.4E-10
score: 49.5
IPR001478PDZ domainPROSITEPS50106PDZcoord: 200..279
score: 12.526
IPR035892C2 domain superfamilyGENE3DG3DSA:2.60.40.150coord: 31..180
e-value: 1.3E-5
score: 26.8
IPR036034PDZ superfamilyGENE3DG3DSA:2.30.42.10coord: 190..283
e-value: 4.9E-17
score: 63.7
IPR036034PDZ superfamilySUPERFAMILYSSF50156PDZ domain-likecoord: 189..281
NoneNo IPR availablePANTHERPTHR46848FAMILY NOT NAMEDcoord: 32..331
NoneNo IPR availableCDDcd00992PDZ_signalingcoord: 200..275
e-value: 8.93151E-13
score: 61.8138
NoneNo IPR availableTMHMMTMhelixcoord: 125..147