Protein kinase domain containing protein

Overview
NameProtein kinase domain containing protein
Smed IDSMED30020244
Length (bp)1731
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein kinase domain containing protein (SMED30020244) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein kinase domain containing protein (SMED30020244) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein kinase domain containing protein (SMED30020244) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein kinase domain containing protein (SMED30020244) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30020244

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 18

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30020244h1SMcG0020718 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30020244h1SMcG0020718 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30020244h1SMcG0020717 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30020244h1SMcG0020717 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
gutSMED30020244h1SMcG0021503 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30020244h1SMcG0021503 Contig4368GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020244h1SMcG0010889 Contig3848newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020244h1SMcG0010889 Contig3848uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020244h1SMcG0020717 Contig3848newmark_estsPMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30020244h1SMcG0020717 Contig3848uc_Smed_v2PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
cephalic gangliaSMED30020244h1SMcG0020717 dd_Smed_v4_15062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30020244h1SMcG0020717 dd_Smed_v4_15062_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020717 Contig30222newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020717 Contig30222uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020716 Contig30222newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020716 Contig30222uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020715 Contig30222newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30020244h1SMcG0020715 Contig30222uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 114.005 bits (284), Expect = 6.122e-26
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  444 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 594
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 114.005 bits (284), Expect = 6.122e-26
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  444 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 594
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 114.005 bits (284), Expect = 6.986e-26
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  440 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 590
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 113.62 bits (283), Expect = 7.066e-26
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  413 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 563
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Match: MAP3K3 (mitogen-activated protein kinase kinase kinase 3 [Source:HGNC Symbol;Acc:HGNC:6855])

HSP 1 Score: 113.62 bits (283), Expect = 7.419e-26
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  409 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 559
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Match: air-1 (Aurora/Ipl1 Related kinase; Aurora/Ipl1-related protein kinase 1 [Source:UniProtKB/TrEMBL;Acc:G5EDL3])

HSP 1 Score: 98.9821 bits (245), Expect = 1.724e-22
Identity = 73/257 (28.40%), Postives = 125/257 (48.64%), Query Frame = 2 
Query:  848 FKTGEKIASGRV-KVYRIKGSGTDRMFVLKGVPSAD------NKYLERNI-IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKH-VN-LNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKL---KDISNDMKAVITKTLKEDPTKR 1579
            F  G  +  G+   V+  +   T R+  LK +          +  L+R I IQ+   L H  I+  YG     K +++++DYA    L + +++ P H VN + A R+ +Q+   L + H  G+IHRD+KP N+LLD + N+KLADF +S V      +  + +T CGT  YL PE+  N         + + +  DIW+ G+ L  ML  +         K+   +   K+     +++   ++I   +K++P +R
Sbjct:   44 FDVGRPLGKGKFGNVFISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYH--LRHPNILTLYGYFHDDKRVFVILDYASRGELFNVLQSQPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLLDSKLNLKLADFGWSVV-----ADHSKRHTLCGTMDYLAPEMVSN---------QPHDFNVDIWAIGILLFEMLVGYAPFANQTGDKLIARIKECKIYIPSVVTDGAASLINAIIKKEPQER 284
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Match: air-1 (Aurora/Ipl1 Related kinase; Aurora/Ipl1-related protein kinase 1 [Source:UniProtKB/TrEMBL;Acc:G5EDL3])

HSP 1 Score: 98.9821 bits (245), Expect = 1.724e-22
Identity = 73/257 (28.40%), Postives = 125/257 (48.64%), Query Frame = 2 
Query:  848 FKTGEKIASGRV-KVYRIKGSGTDRMFVLKGVPSAD------NKYLERNI-IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKH-VN-LNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKL---KDISNDMKAVITKTLKEDPTKR 1579
            F  G  +  G+   V+  +   T R+  LK +          +  L+R I IQ+   L H  I+  YG     K +++++DYA    L + +++ P H VN + A R+ +Q+   L + H  G+IHRD+KP N+LLD + N+KLADF +S V      +  + +T CGT  YL PE+  N         + + +  DIW+ G+ L  ML  +         K+   +   K+     +++   ++I   +K++P +R
Sbjct:   44 FDVGRPLGKGKFGNVFISREKKTKRIIALKVLFKTQLLQLGVSHQLKREIEIQYH--LRHPNILTLYGYFHDDKRVFVILDYASRGELFNVLQSQPGHKVNEVIAGRFVRQLANALHYCHSKGVIHRDIKPENLLLDSKLNLKLADFGWSVV-----ADHSKRHTLCGTMDYLAPEMVSN---------QPHDFNVDIWAIGILLFEMLVGYAPFANQTGDKLIARIKECKIYIPSVVTDGAASLINAIIKKEPQER 284
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4])

HSP 1 Score: 100.908 bits (250), Expect = 3.028e-22
Identity = 67/240 (27.92%), Postives = 111/240 (46.25%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYS-----------KQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEA---YTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEI-LAN------------EKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            IQ +   NH  ++ YY    + + L++VM      S+ D +K   K +     ++            ++VL+GLE+ H NG IHRD+K GNILL  +  +++ADF  S  L    G+       +T+ GTP ++ PE+   +        +GY + ADIWS G+  I + +      +    K+  + L N            ++ K      K +I   L++DP KRP+ + LL+   F
Sbjct:  155 IQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQV--------QGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF 386
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4])

HSP 1 Score: 100.908 bits (250), Expect = 3.655e-22
Identity = 67/240 (27.92%), Postives = 111/240 (46.25%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYS-----------KQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEA---YTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEI-LAN------------EKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            IQ +   NH  ++ YY    + + L++VM      S+ D +K   K +     ++            ++VL+GLE+ H NG IHRD+K GNILL  +  +++ADF  S  L    G+       +T+ GTP ++ PE+   +        +GY + ADIWS G+  I + +      +    K+  + L N            ++ K      K +I   L++DP KRP+ + LL+   F
Sbjct:  155 IQAMSQCNHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQV--------QGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF 386
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Match: gck-3 (Germinal center kinase 3 [Source:UniProtKB/Swiss-Prot;Acc:G5EEN4])

HSP 1 Score: 97.8265 bits (242), Expect = 1.345e-21
Identity = 65/233 (27.90%), Postives = 108/233 (46.35%), Query Frame = 2 
Query:  998 NHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYS-----------KQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEA---YTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEI-LAN------------EKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            NH  ++ YY    + + L++VM      S+ D +K   K +     ++            ++VL+GLE+ H NG IHRD+K GNILL  +  +++ADF  S  L    G+       +T+ GTP ++ PE+   +        +GY + ADIWS G+  I + +      +    K+  + L N            ++ K      K +I   L++DP KRP+ + LL+   F
Sbjct:    5 NHPNVVSYYTSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNGQIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQV--------QGYDFKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRDCLQKDPAKRPTASELLKYSFF 229
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0343587)

HSP 1 Score: 105.531 bits (262), Expect = 3.116e-24
Identity = 71/219 (32.42%), Postives = 111/219 (50.68%), Query Frame = 2 
Query:  992 LLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPE-IERNLDQGGTGNTEGYTYPADIWSFGVTLIYML---------SDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            ++ H  II    V ES   +++V +      L D + +             +Q+ EG+E++H   I+HRDLKP NILLD   NVK+ DF F++ L+  EGE +     CGTP YL PE ++ N+ +G    + GY+   DIW+ GV +  +L              ++ +  GK S    + +  DIS D K +I K L  DP++R +V  +L+   F+
Sbjct:   84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQ--EGEKLT--NLCGTPGYLAPETLKCNMFEG----SPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYS--FTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFN 292
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Match: grp (gene:FBgn0261278 transcript:FBtr0080886)

HSP 1 Score: 107.071 bits (266), Expect = 3.141e-24
Identity = 69/196 (35.20%), Postives = 102/196 (52.04%), Query Frame = 2 
Query:  869 ASGRVKVYRIKGSGTD---RMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS 1447
            A G VK+   + +G     +M  LK  P A N   +   IQ   +L  + I++++G    G   YI ++YA    L D+I+ D       A RY  Q+L GL +LH+ GI HRDLKP N+LLD  DNVK++DF  + + +  +G+       CGT  Y+ PE+ +            +  PAD+WS GV L+ ML+
Sbjct:   32 AYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQ--KMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRC-KGKERLLDKRCGTLPYVAPEVLQK---------AYHAQPADLWSCGVILVTMLA 215
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Match: grp (gene:FBgn0261278 transcript:FBtr0080885)

HSP 1 Score: 107.071 bits (266), Expect = 3.141e-24
Identity = 69/196 (35.20%), Postives = 102/196 (52.04%), Query Frame = 2 
Query:  869 ASGRVKVYRIKGSGTD---RMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS 1447
            A G VK+   + +G     +M  LK  P A N   +   IQ   +L  + I++++G    G   YI ++YA    L D+I+ D       A RY  Q+L GL +LH+ GI HRDLKP N+LLD  DNVK++DF  + + +  +G+       CGT  Y+ PE+ +            +  PAD+WS GV L+ ML+
Sbjct:   32 AYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQ--KMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRC-KGKERLLDKRCGTLPYVAPEVLQK---------AYHAQPADLWSCGVILVTMLA 215
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Match: grp (gene:FBgn0261278 transcript:FBtr0080884)

HSP 1 Score: 107.071 bits (266), Expect = 3.141e-24
Identity = 69/196 (35.20%), Postives = 102/196 (52.04%), Query Frame = 2 
Query:  869 ASGRVKVYRIKGSGTD---RMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS 1447
            A G VK+   + +G     +M  LK  P A N   +   IQ   +L  + I++++G    G   YI ++YA    L D+I+ D       A RY  Q+L GL +LH+ GI HRDLKP N+LLD  DNVK++DF  + + +  +G+       CGT  Y+ PE+ +            +  PAD+WS GV L+ ML+
Sbjct:   32 AYGEVKLLINRQTGEAVAMKMVDLKKHPDAANSVRKEVCIQ--KMLQDKHILRFFGKRSQGSVEYIFLEYAAGGELFDRIEPDVGMPQHEAQRYFTQLLSGLNYLHQRGIAHRDLKPENLLLDEHDNVKISDFGMATMFRC-KGKERLLDKRCGTLPYVAPEVLQK---------AYHAQPADLWSCGVILVTMLA 215
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Match: PhKgamma (gene:FBgn0011754 transcript:FBtr0090002)

HSP 1 Score: 105.531 bits (262), Expect = 4.203e-24
Identity = 71/219 (32.42%), Postives = 111/219 (50.68%), Query Frame = 2 
Query:  992 LLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPE-IERNLDQGGTGNTEGYTYPADIWSFGVTLIYML---------SDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            ++ H  II    V ES   +++V +      L D + +             +Q+ EG+E++H   I+HRDLKP NILLD   NVK+ DF F++ L+  EGE +     CGTP YL PE ++ N+ +G    + GY+   DIW+ GV +  +L              ++ +  GK S    + +  DIS D K +I K L  DP++R +V  +L+   F+
Sbjct:   84 VMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSEKKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILLDENHNVKITDFGFAKQLQ--EGEKLT--NLCGTPGYLAPETLKCNMFEG----SPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYS--FTSPEWADISEDPKDLIRKCLVVDPSQRITVKEVLRHPFFN 292
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 115.161 bits (287), Expect = 1.817e-26
Identity = 65/161 (40.37%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  407 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGA-LTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 557
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 114.775 bits (286), Expect = 2.090e-26
Identity = 65/161 (40.37%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  413 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGA-LTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 563
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:ZFIN;Acc:ZDB-GENE-070910-1])

HSP 1 Score: 114.775 bits (286), Expect = 2.095e-26
Identity = 75/218 (34.40%), Postives = 116/218 (53.21%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS------DFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML+      +F+ +  +   KI+    N +L    ++      + +  +   RPS   LL+
Sbjct:  395 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAYGA-LTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEFEAMAAI--FKIATQPTNPQLPSHISEHTRDFLRCIFVEAKYRPSAEELLR 600
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Match: si:ch211-197l9.5 (si:ch211-197l9.5 [Source:ZFIN;Acc:ZDB-GENE-091204-323])

HSP 1 Score: 107.457 bits (267), Expect = 8.694e-25
Identity = 84/266 (31.58%), Postives = 126/266 (47.37%), Query Frame = 2 
Query:  839 GKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS-------DFDTVKQVQ----NGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            G    TGEK+A   +KV   K +  D  +VLK      N   E  I Q   L+ H  I+     +E+    Y+ M+      L D+I    +       R+++Q+L  +EHLH++GI+HRDLK  N LLD  +N+K+ DF  S  LKG         T CG+P Y  PE+  +         + Y    D+WS GV++  ML+       +   +KQ+     NG+IS I +     DIS      +   L+ +P KRP+V A ++
Sbjct:   64 GMNISTGEKVA---IKVIDKKKARQDS-YVLK------NMKREPRIHQ---LIRHPNIVLLLETLETENCYYMAMELCGGGDLMDRICERKRLDEREVRRFTRQILSAVEHLHRHGIVHRDLKIENFLLDEHNNIKIVDFGLSNTLKGDSLSVDLLNTQCGSPAYAAPELLAH---------KKYGPKVDVWSVGVSMFAMLTGTLPFTVEPFNIKQLHQKMVNGEISPIPS-----DISKAAVEFVLSLLEPEPAKRPTVKAAME 302
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Match: chek2 (checkpoint kinase 2 [Source:NCBI gene;Acc:336998])

HSP 1 Score: 108.997 bits (271), Expect = 9.464e-25
Identity = 77/222 (34.68%), Postives = 114/222 (51.35%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDN---VKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTV----------KQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            I+ L  ++H  +IK     ++  + YIV++Y     L  +IKA  K     A  Y  Q+L+ +E+LH NGIIHRDLKP N+LL   D+   +K+ DF  S++L+    E     T CGTP Y+ PE+  +       +T GYT   D WS GV L   L  +             +Q+ NG+   I +  + K++SN+ K ++ K L  DP KR SV   L+
Sbjct:  243 IEILKKIDHPCLIKTEDFYQTEDSYYIVLEYIEGGELFGRIKAKKKLEEDIAKLYFYQMLKAVEYLHNNGIIHRDLKPENVLLASHDDICLIKITDFNQSKILE----ESSLMKTLCGTPTYVAPEVFTH------ASTVGYTKAVDYWSLGVLLFICLGGYPPFNTECTTMSVREQIINGEYRFIPS--QWKNVSNEAKDLVKKLLVVDPQKRLSVEEALE 452
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 113.235 bits (282), Expect = 8.791e-26
Identity = 62/160 (38.75%), Postives = 92/160 (57.50%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+H+RI++YYG +  +  K L I M+Y    S++D++KA          RY++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  416 IQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 566
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Match: samd8 (sterile alpha motif domain containing 8 [Source:Xenbase;Acc:XB-GENE-1012742])

HSP 1 Score: 112.849 bits (281), Expect = 1.352e-25
Identity = 62/160 (38.75%), Postives = 92/160 (57.50%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+H+RI++YYG +  +  K L I M+Y    S++D++KA          RY++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  398 IQLLKNLHHDRIVQYYGSLRDKGEKTLTIFMEYMPGGSVKDQLKAYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 548
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 111.694 bits (278), Expect = 3.616e-25
Identity = 63/160 (39.38%), Postives = 90/160 (56.25%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESG--KNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +     K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   ADIWS G T++ ML++
Sbjct:  418 IQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI---------SGEGYGRKADIWSVGCTVVEMLTE 568
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Match: MAP3K2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:100493570])

HSP 1 Score: 110.923 bits (276), Expect = 4.525e-25
Identity = 63/160 (39.38%), Postives = 90/160 (56.25%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESG--KNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +     K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   ADIWS G T++ ML++
Sbjct:  390 IQLLKNLLHERIVQYYGCLRDSQEKTLSIFMEYMPGGSIKDQLKAYGALTEFVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI---------SGEGYGRKADIWSVGCTVVEMLTE 540
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Match: dennd1a (DENN domain containing 1A [Source:Xenbase;Acc:XB-GENE-5729862])

HSP 1 Score: 110.153 bits (274), Expect = 9.410e-25
Identity = 71/219 (32.42%), Postives = 116/219 (52.97%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKG--PEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYML------SDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            IQ L L  HERI++YYG +   + + L I ++Y    S++D++KA          RY++Q+L+G+ +LH N I+HRD+K  NIL D   NVKL DF  S+ ++     G  +++ T  GTPY++ PE+          + EGY   AD+WS   T++ ML      S+++ +  +   KI+      +L D  +D      K +  +  +RP+   LL+
Sbjct:  405 IQLLKLHRHERIVQYYGCLRDPTERKLSIFVEYMPGGSIKDQLKAYGALTENVTRRYTRQILQGVSYLHGNMIVHRDIKGANILRDSAGNVKLGDFGASKRIQTICMSGTGIKSVT--GTPYWMSPEVI---------SGEGYGRKADVWSVACTVVEMLTEKPPWSEYEAMAAI--FKIATQPTKPRLPDTVSDACRDFMKQIFVEEKRRPTAEELLR 610
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Match: Map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:MGI Symbol;Acc:MGI:1346874])

HSP 1 Score: 112.464 bits (280), Expect = 1.282e-25
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  413 IQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 563
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Match: Map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:MGI Symbol;Acc:MGI:1346873])

HSP 1 Score: 109.383 bits (272), Expect = 1.304e-24
Identity = 95/278 (34.17%), Postives = 134/278 (48.20%), Query Frame = 2 
Query:  821 CPTSIR-GKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGV---PSADNKYLERNI----IQFLDLLNHERIIKYYGVIESG--KNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS------DFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
             PT+ R GK    G   A GRV  Y      T R   +K V   P +     E N     IQ L  L HERI++YYG +     K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   N+KL DF  S+ L+          +  GTPY++ PE+          + EGY   ADIWS   T++ ML+      +F+ +  +   KI+    N KL    +D      K +  +   RPS   LL+
Sbjct:  352 APTNWRLGKLLGQG---AFGRV--YLCYDVDTGRELAVKQVQFNPESPETSKEVNALECEIQLLKNLLHERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAY-GALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVI---------SGEGYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAI--FKIATQPTNPKLPPHVSDYTRDFLKRIFVEAKLRPSAEELLR 612
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Match: 4921509C19Rik (RIKEN cDNA 4921509C19 gene [Source:MGI Symbol;Acc:MGI:2685851])

HSP 1 Score: 107.842 bits (268), Expect = 3.995e-24
Identity = 73/236 (30.93%), Postives = 120/236 (50.85%), Query Frame = 2 
Query:  911 TDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEF-SRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS--------DFDTVKQ-VQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSV 1588
            T     +K +P +    L +  I+ +  L+H  IIK   +I++ +N++IV+++AV   L  +I+       +   R  KQ++  L++ H+ GI+HRDLKP NILLD   NVKL DF   ++++ G      +  T+CGT  Y  PE+    D+G  G         D+WS GV L +M +         ++ +KQ +  GK     +      +S ++  VI K L  +P +RP+V
Sbjct:   46 TQTKVAIKILPKSRKNSLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMG-----QKLVTFCGTLPYCAPELFE--DRGYDGRA------TDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKYPRSFS------LSPELWEVIAKLLTVNPGERPTV 262
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Match: Gm14147 (predicted gene 14147 [Source:MGI Symbol;Acc:MGI:3651555])

HSP 1 Score: 106.686 bits (265), Expect = 9.162e-24
Identity = 73/236 (30.93%), Postives = 120/236 (50.85%), Query Frame = 2 
Query:  911 TDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEF-SRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS--------DFDTVKQ-VQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSV 1588
            T     +K +P      L +  I+ +  L+H  IIK   +I++ +N++IV+++AV   L ++I+       +   R  KQ++  L++ H+ GI+HRDLKP NILLD   NVKL DF   ++++ G      +  T+CGT  Y  PE+    D+G  G         D+WS GV L +M +         ++ +KQ +  GK     +      +S ++  VI K L  +P +RP+V
Sbjct:   46 TQTKVAIKILPQNRKNPLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMG-----QKLVTFCGTLPYCAPELFE--DRGYDGRA------TDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKYPRSFS------LSPELWEVIAKLLTVNPGERPTV 262
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Match: Gm14147 (predicted gene 14147 [Source:MGI Symbol;Acc:MGI:3651555])

HSP 1 Score: 106.686 bits (265), Expect = 9.162e-24
Identity = 73/236 (30.93%), Postives = 120/236 (50.85%), Query Frame = 2 
Query:  911 TDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEF-SRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS--------DFDTVKQ-VQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSV 1588
            T     +K +P      L +  I+ +  L+H  IIK   +I++ +N++IV+++AV   L ++I+       +   R  KQ++  L++ H+ GI+HRDLKP NILLD   NVKL DF   ++++ G      +  T+CGT  Y  PE+    D+G  G         D+WS GV L +M +         ++ +KQ +  GK     +      +S ++  VI K L  +P +RP+V
Sbjct:   46 TQTKVAIKILPQNRKNPLVQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEVECHRLFKQLVYALQYCHEKGIVHRDLKPENILLDHRGNVKLTDFGLGTKIIMG-----QKLVTFCGTLPYCAPELFE--DRGYDGRA------TDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKYPRSFS------LSPELWEVIAKLLTVNPGERPTV 262
[Close]
BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Match: sp|Q39008|M3K1_ARATH (Mitogen-activated protein kinase kinase kinase 1 OS=Arabidopsis thaliana OX=3702 GN=MEKK1 PE=1 SV=2)

HSP 1 Score: 115.161 bits (287), Expect = 1.217e-25
Identity = 83/269 (30.86%), Postives = 129/269 (47.96%), Query Frame = 2 
Query:  845 TFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSADNKYLERNIIQ-------FLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYC-GTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYM------LSDFDTVK---QVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALL 1600
            +++ G+ +  G         SG    F +K V   D     +  IQ        L  L H+ I++Y G  + G NLYI ++     SL  K+    +  +   + Y++Q+L+GL++LH  G IHRD+K  NIL+D    VKLADF  ++V K            C GTP+++ PE+    D      ++GY  PADIWS G T++ M       SD + V+   ++  G + E+        +S D +  I K LK +P +RP+   LL
Sbjct:  332 SWQKGQLLGRGSFGSVYEGISGDGDFFAVKEVSLLDQGSQAQECIQQLEGEIKLLSQLQHQNIVRYRGTAKDGSNLYIFLELVTQGSLL-KLYQRYQLRDSVVSLYTRQILDGLKYLHDKGFIHRDIKCANILVDANGAVKLADFGLAKVSK------FNDIKSCKGTPFWMAPEVINRKD------SDGYGSPADIWSLGCTVLEMCTGQIPYSDLEPVQALFRIGRGTLPEVPDT-----LSLDARLFILKCLKVNPEERPTAAELL 582
[Close]
BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Match: sp|Q99759|M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens OX=9606 GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 113.62 bits (283), Expect = 3.393e-25
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  413 IQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 563
[Close]
BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Match: sp|Q61084|M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus OX=10090 GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 8.968e-25
Identity = 62/160 (38.75%), Postives = 91/160 (56.88%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L HERI++YYG +   + K L I M+Y    S++D++KA          +Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++
Sbjct:  413 IQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTE 563
[Close]
BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Match: sp|Q54MH0|FHKD_DICDI (Probable serine/threonine-protein kinase fhkD OS=Dictyostelium discoideum OX=44689 GN=fhkD PE=3 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 1.278e-24
Identity = 78/229 (34.06%), Postives = 110/229 (48.03%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDN-----VKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNL--DQGGTGNTEGYTYPADIWSFGVTLIYMLS-----DFDTVKQVQNGKISEILANEKLK---DISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            ++ L  + H  II    +++S +  YIV++ A    L +KIK   +     A    KQ+LE + +LH   I HRDLKP NIL+    +     +K+ DF  ++++    GE   A T CGTP Y+ PEI RN     GG     GY    D+WS G  L  +LS     DFD         I++ L N  L     ++ + K +I K L  DPTKR S    L  D F+
Sbjct:  249 VEILQKIKHPNIISIIDIVQSDRYFYIVLELATGGELFEKIKQKGRFSEPEAKDTFKQILEAVSYLHDLNISHRDLKPENILISAVSHGKSSVIKVTDFGLAKII----GEKEMATTLCGTPLYVAPEIIRNCLHGDGGAQVNTGYGKEVDVWSLGCILYILLSGRPPFDFDHTNNFNLKLINQGLYNFSLPVWDVVTENAKDLIKKLLNVDPTKRISTKGALSHDWFN 473
[Close]
BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Match: sp|Q84VQ3|CIPKQ_ARATH (CBL-interacting serine/threonine-protein kinase 26 OS=Arabidopsis thaliana OX=3702 GN=CIPK26 PE=1 SV=2)

HSP 1 Score: 108.997 bits (271), Expect = 4.253e-24
Identity = 59/162 (36.42%), Postives = 93/162 (57.41%), Query Frame = 2 
Query:  968 RNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDF 1453
            R  I  + L+NH  +++ Y V+ S   +YIV+++     L DKI  D +    NA +Y +Q++  +++ H  G+ HRDLKP N+LLD + N+K++DF  S + +   G+ +  +T CGTP Y  PE+    DQG  G T      AD+WS GV L  +L+ +
Sbjct:   59 RREICTMKLINHPNVVRLYEVLASKTKIYIVLEFGTGGELFDKIVHDGRLKEENARKYFQQLINAVDYCHSRGVYHRDLKPENLLLDAQGNLKVSDFGLSALSRQVRGDGL-LHTACGTPNYAAPEVLN--DQGYDGAT------ADLWSCGVILFVLLAGY 211
[Close]
BLAST of Protein kinase domain containing protein vs. TrEMBL
Match: A0A0H3YJG2 (Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc42a-1 PE=2 SV=1)

HSP 1 Score: 189.119 bits (479), Expect = 1.991e-47
Identity = 155/511 (30.33%), Postives = 235/511 (45.99%), Query Frame = 2 
Query:  125 DKMSEFQAF---VDSIKLGNFESFVQLYKPEYLN-KKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMG--GRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRV-KVYRIKGSGTDRMFVLKGVPSAD--NKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKL----------KDISNDMKAVITKTLKEDPTKRPSVTALL 1600
            ++ SEF+ F   + +IK G+ E   + Y    L  K    S   I YAC++GH+++++  I   C+++      R  L     A      DIV LL ++   I +          P+                         S+L              PIH A +  + E  +LL+ +NCD+  LDK  ++P  IA     + +IK++ E +    +R + + M + C G  C+HKFC TS + K  K  + IASG    V+    SGTDR F +K +P  +   +Y+E NI  F +LL HERI+K++G     +N YI M+Y      +   K  P  + L    ++KQ+LE L  LH+  IIHRD+KP N+LLD + N+KL+DF  S +L     +  +    CGT  Y  PEI          N E YT   DIWS G T+I + +       + +G I  +++  +           K ISN    +I   L++D  KR S   LL
Sbjct:  499 ERYSEFEKFGQLIKAIKDGSIEDVKKYYSRRILEIKLGSYSRSPILYACKYGHRKIVKYFIKQKCNVDSFDCEFRRAL---HYAVISNNNDIVKLLIESGAAINV----------PD-------------------------SLLM------------MPIHLACKVNNIEAAQLLMENNCDMVTLDKLKRSPLQIAETGDFENMIKLIKECQ---IIREIAAEMQLKC-GKLCNHKFCYTSFQRKKIKNRKCIASGSYGTVFLYNESGTDRKFAVKKIPKQNIRARYIEANINDFKNLLCHERIVKHFGAFHKKENHYIFMEYLDTLQKKKYQKKSPGDLLL----FAKQILEALSFLHERSIIHRDIKPENVLLDIDGNLKLSDFGLSLLLSSVAEDIQKEGRCCGTYCYAAPEI---------LNAELYTCSVDIWSLGATMIQLCTGQPPYHNLGDGAIITVISTTREIEYKLPEYMPKYISN----LIDHMLEKDQYKRLSAKKLL 938
[Close]
BLAST of Protein kinase domain containing protein vs. TrEMBL
Match: K1PKP1 (Mitogen-activated protein kinase kinase kinase 2 OS=Crassostrea gigas OX=29159 GN=CGI_10008499 PE=4 SV=1)

HSP 1 Score: 126.331 bits (316), Expect = 2.392e-28
Identity = 91/273 (33.33%), Postives = 135/273 (49.45%), Query Frame = 2 
Query:  821 CPTSIR-GKTFKTGEKIASGRVKVYRIKGSGTD------RMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKL------KDISNDMKAVITKTLKEDPTKRPSVTALL 1600
            CP + + G    +G   A G V V   K +G D      R+  +    S + + LE N I  L    HERI+ Y+G  +  ++LYI M+Y    S++D+I          + +Y+KQ+LEGL +LHKN I+HRD+K  NIL DG  N+KL DF  S+ L+         ++  GTPY++ PE+          N EGY   ADIWS G T++ ML+      + ++      +A EK         IS     V++K    +P+ RP+   LL
Sbjct:   60 CPVNWKAGALLGSG---AFGEVYVCHDKDTGRDLAMKVVRLEQMNAETSKEVRALE-NEIHLLRNFEHERIVSYFGCAQDKQSLYIFMEYLPGGSVKDEITKYGSLTENVSRKYTKQMLEGLAYLHKNVIVHRDIKGANILRDGNGNIKLGDFGASKRLQTIV-SATGLHSVVGTPYWMAPEVI---------NGEGYGRKADIWSVGCTIVEMLTTKPPWAEFESMAALYKIAMEKRPHFTLPNHISELCHDVLSKAFDRNPSTRPTAIDLL 318
[Close]
BLAST of Protein kinase domain containing protein vs. TrEMBL
Match: A0A1A8JDE5 (CHK2 checkpoint homolog (Fragment) OS=Nothobranchius kuhntae OX=321403 GN=CHEK2 PE=4 SV=1)

HSP 1 Score: 124.79 bits (312), Expect = 6.458e-28
Identity = 83/256 (32.42%), Postives = 131/256 (51.17%), Query Frame = 2 
Query:  884 KVYRIKGSGTDRMFVLKGVPS---ADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNV---KLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDF----------DTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            +V+R++   T + + +K + +   A  +  E  +   L  + H  II+   V E+ + +Y+VM+ A    L D+I A       +ATR  + VL+G+++LH  GI HRDLKP NILL   ++V   K+ DF  SR+L+    E     T CGTPYY+ PE+  +       +T GY    D WS GV L   LS +             +Q+  G+ +  +   K K++S+  K V+ K L+ DP+KR ++   LQ
Sbjct:    4 RVFRVEHRSTRQPYAIKMIETRYRAGREVCESELC-VLHRVRHTNIIQLMEVFETAERVYMVMELATGGELFDRIIARGSFTERDATRVLQMVLDGVKYLHALGITHRDLKPENILLASNEDVCLIKVTDFNQSRILE----EAALVRTLCGTPYYVAPEVLTH------ASTTGYGIEVDAWSLGVLLFVCLSGYTPFHENFSKLSVTEQIIRGEFT--MVPSKWKNVSDQAKDVVRKLLEVDPSKRMTIREALQ 246
[Close]
BLAST of Protein kinase domain containing protein vs. TrEMBL
Match: A0A2C9U556 (Uncharacterized protein OS=Manihot esculenta OX=3983 GN=MANES_17G061900 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.368e-26
Identity = 100/394 (25.38%), Postives = 186/394 (47.21%), Query Frame = 2 
Query:  455 NEKIVDILKGRKFLLACKKGDLETVRSML-TDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSADNKYLE-RNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKN--GIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAY-TYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEK-------LKDISNDMKAVITKTLKEDPTKRPSVTALL 1600
             E++ +I  G + + +  +G+L+ +R +L + ++V + D DNR  +H A   G+ ++V LLL     +D  D+    P   A   +N ++IK+L E+R  +PL   ++ M V    +  +++  P  +    F   ++I  G  ++   +G       + + V S + K    R+ +  L  + H  ++++ G +     + IV +Y     L   +K         A R++  +  GL +LH+N   IIHRDL+P NIL D   ++K+ADF  S++L   E +P+    T C    Y+ PE+ +N         E Y    D++SF + L  M+         Q  ++ +  A ++        K  S+ +K +I +   E+P KRP+   ++
Sbjct:   30 QEELEEIDPGVRLMYSANEGNLDAIRELLDSGIDVNFRDIDNRTALHVAACQGNADVVALLLDKGAQVDTRDRWGSTPLADAIYYKNHDVIKLL-EKRGAKPL---MAPMHVNHAREVPEYEINPAEL---DFTNSKEITKGTFRIASWRGIQVAVKRLGEDVISDEEKVKAFRDELALLQKIRHPNVVQFLGAVTQSSPMMIVTEYLPKGDLCAYMKGKGALKTGTAVRFALDIARGLNYLHENKPPIIHRDLEPSNILRDDSGHLKVADFGVSKLLTVKEDKPLSCLDTSC---RYVAPEVFKN---------EEYDTKVDVFSFALILQEMIEGCPPFSAKQEDEVPKSYAAKERPPFRAPTKHYSHGLKELIQECWNENPAKRPTFRQII 404
[Close]
BLAST of Protein kinase domain containing protein vs. TrEMBL
Match: B9S8G7 (Protein kinase, putative OS=Ricinus communis OX=3988 GN=RCOM_1252900 PE=4 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.641e-26
Identity = 102/395 (25.82%), Postives = 187/395 (47.34%), Query Frame = 2 
Query:  452 PNEKIVDILKGRKFLLACKKGDLETVRSML-TDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSADNKYLE-RNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKN--GIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAY-TYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEK-------LKDISNDMKAVITKTLKEDPTKRPSVTALL 1600
            P E++ DI  G + + +C +GDL+ +R +L + ++V + D DNR  +H A   G+T++V LLL +  + D  D+    P   A   +N ++IK+L E+R  +PL   ++ M V    +  +++  P  +    F    +I  G   +   +G       + + V S ++K     + +  L  + H  ++++ G +     + IV +Y     L   +K         A R+   +  GL +LH+N   IIHRDL+P NIL D   ++K+ADF  S++L   E +P+    T C    Y+ PE+ ++         E Y    D++SF + L  M+         Q+ ++ +  A ++        K   + +K +I +   E+P KRP+   ++
Sbjct:   42 PEEELEDIHPGVRLMYSCHEGDLDGIRELLDSGIDVNFRDIDNRTALHLAACQGYTDVVALLLNNGAETDPKDRWGSTPLADAIYYKNHDVIKLL-EKRGAKPL---MAPMHVNHAREVPEYEINPHEL---DFTNSVEITKGTFHLASWRGIQVAVKKLGEDVISDEDKVRAFSDELALLQKIRHPNVVQFLGAVTQSSPMMIVTEYLHKGDLRAFLKKKGALRPGTAVRFGLDIARGLNYLHENKPPIIHRDLEPSNILRDDSGHLKVADFGVSKLLTVKEDKPLTCQDTSC---RYVAPEVFKH---------EEYDTKVDVFSFALILQEMIEGCPPFSAKQDLEVPKSYAAKERPPFRAPTKHYPHGLKDLIQECWNENPAKRPTFRQII 417
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 113.62 bits (283), Expect = 4.712e-26
Identity = 64/161 (39.75%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + +GY   AD+WS G T++ ML++
Sbjct:  407 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAY-GALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGDGYGRKADVWSLGCTVVEMLTE 557
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 113.62 bits (283), Expect = 4.712e-26
Identity = 64/161 (39.75%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + +GY   AD+WS G T++ ML++
Sbjct:  407 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAY-GALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGDGYGRKADVWSLGCTVVEMLTE 557
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:103034596])

HSP 1 Score: 113.62 bits (283), Expect = 4.712e-26
Identity = 64/161 (39.75%), Postives = 95/161 (59.01%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            IQ L  L+HERI++YYG +   + K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + +GY   AD+WS G T++ ML++
Sbjct:  407 IQLLKNLHHERIVQYYGCLRDHNEKTLTIFMEYMPGGSVKDQLKAY-GALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSSTGVRSVTGTPYWMSPEVI---------SGDGYGRKADVWSLGCTVVEMLTE 557
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Match: chek2 (checkpoint kinase 2 [Source:NCBI gene;Acc:103034962])

HSP 1 Score: 111.309 bits (277), Expect = 1.519e-25
Identity = 76/222 (34.23%), Postives = 114/222 (51.35%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDN---VKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTV----------KQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            I+ L  ++H  +I+     ++ ++ YIV++Y     L  KIK + +     A  Y  Q+L+ +E+LH+NGIIHRDLKP N+LL   ++   +K+ DF  S++L+    E     T CGTP YL PE+        TG   GYT   D WS GV L   L  +             +Q+ NG+   I +  + K +SN  K ++ K L  DP KR S++  LQ
Sbjct:  238 IEILKKIDHPCLIRTEDFYQTEESYYIVLEYVEGGELFTKIKTEKQLKEEIAKLYFYQMLKAVEYLHENGIIHRDLKPENVLLTSHEDECLIKITDFNQSKILE----ESSLMKTLCGTPTYLAPEV---FTAASTG---GYTRAVDCWSLGVLLFICLGGYPPFNTESSPLPVREQIINGQYCFIRS--QWKSVSNAAKDLVKKLLVVDPVKRISISEALQ 447
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Match: sik1 (serine/threonine-protein kinase SIK2-like [Source:NCBI gene;Acc:103047200])

HSP 1 Score: 109.768 bits (273), Expect = 1.117e-24
Identity = 72/215 (33.49%), Postives = 108/215 (50.23%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPA---DIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLK---DISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            +Q + LLNH  IIK Y V+E+   LYIV +YA N  + D + ++ +     A +   Q+L  +++ H++ I+HRDLK  N+LLD   N+KLADF F    K   GEP+   T+CG+P Y  PE+            EG  Y     DIWS GV L  ++             + + +   + +    +S D + +I K L  DP KR +V  + Q
Sbjct:   74 VQIMKLLNHPHIIKLYQVMETKDMLYIVTEYAKNGEMFDFLTSNGRMSEAEARKKFWQILTAVDYCHRHHIVHRDLKTENLLLDANMNIKLADFGFGNFYK--TGEPLS--TWCGSPPYAAPEV-----------FEGKEYEGPQLDIWSLGVVLYVLVCGSLPFDGESLPALRQRVTEGRFRIPFFMSEDCENLIRKMLVVDPAKRITVAQIKQ 273
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:ZFIN;Acc:ZDB-GENE-120215-96])

HSP 1 Score: 112.464 bits (280), Expect = 2.014e-26
Identity = 81/215 (37.67%), Postives = 112/215 (52.09%), Query Frame = 2 
Query:  836 RGKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGV---PSADNKYLERNI----IQFLDLLNHERIIKYYGVIE--SGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSD 1450
            RGK    G   A GRV  Y    + T R   +K V   P +     E N     IQ L  L HERI++Y+G +     K L I M+Y    S++D+++A    +  N TR Y++Q+LEG+  LH N I+HRD+K  NIL D   NVKL DF  S+ L+    +     +  GTPY++ PE+          N EGY   ADIWS G T++ ML++
Sbjct:  361 RGKLLGQG---AFGRV--YLCYDADTGRELAVKQVQFDPGSVETSKEVNALECEIQLLKNLQHERIVQYFGCLRDPQQKTLSIFMEYMPGGSIKDQLRAY-GALTENVTRKYTRQILEGVSFLHGNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICSQGTAMRSVTGTPYWMSPEVI---------NGEGYGRKADIWSVGCTVVEMLTE 560
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Match: NEK9 (NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC:18591])

HSP 1 Score: 97.4413 bits (241), Expect = 1.835e-21
Identity = 69/221 (31.22%), Postives = 107/221 (48.42%), Query Frame = 2 
Query:  968 RNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKI--KADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKIS-EILANEKLKDI----SNDMKAVITKTLKEDPTKRPSVTALLQLD 1609
            +N I  L LL H  II YY     G  L I ++Y    +L +KI  +        +   Y  Q++  +E +H   I+HRD+K  NI L   D +K+ DF  S++L   +     A +Y GTPYY+ PE+ R          + Y   +DIW+ G  L  +L+   T       K+  EI+  +K  +I    S ++K V+ K L++D  +RP+   LL+L 
Sbjct:   81 QNEIDILSLLEHANIISYYNHFLDGNVLLIELEYCNGGTLYEKIIKQHGAFFPEKDIVWYFYQLVSAVEQIHNFKILHRDIKTLNIFLTKSDLIKVGDFGISKIL---DSRSQMAESYVGTPYYMSPELIRG---------DKYNTKSDIWAMGCVLYELLTLTRTFDATNPLKLCYEIIHGKKQVEIDDQYSKEIKEVVQKCLQQDAEQRPTAEDLLELS 289
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 96.2857 bits (238), Expect = 5.053e-21
Identity = 57/158 (36.08%), Postives = 89/158 (56.33%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYP-ADIWSFGVTLIYMLS 1447
            ++ + +LNH  I+K + VIE+ K LY+VM+YA    + D + A  +     A    +Q++  +++ H+  I+HRDLK  N+LLD + N+K+ADF FS       G  ++  T+CG+P Y  PE    L QG     + Y  P  D+WS GV L  ++S
Sbjct:  102 VRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFT--LGSKLD--TFCGSPPYAAPE----LFQG-----KKYDGPEVDVWSLGVILYTLVS 246
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Match: stk39 (serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GENE-140106-194])

HSP 1 Score: 92.8189 bits (229), Expect = 9.142e-21
Identity = 56/172 (32.56%), Postives = 87/172 (50.58%), Query Frame = 2 
Query: 1145 KQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLK--GPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKI-------------SEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            K+VLEGL++LH+NG IHRD+K GNILL  +  +++ADF  S  L   G         T+ GTP ++ PE+   +         GY + ADIWSFG+T + + S      +    K+             + +   E +K      + +I++ L++DP KRP+   LL+   F
Sbjct:   12 KEVLEGLDYLHRNGQIHRDVKAGNILLGEDGTIQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQV--------RGYDFKADIWSFGITAMELASGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMVKKYGKSFRKLISQCLQKDPAKRPTAAELLKSKFF 175
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Match: MARK3 (microtubule affinity regulating kinase 3 [Source:HGNC Symbol;Acc:HGNC:6897])

HSP 1 Score: 93.2041 bits (230), Expect = 1.361e-20
Identity = 56/158 (35.44%), Postives = 88/158 (55.70%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYP-ADIWSFGVTLIYMLS 1447
            ++ + +LNH  I+K + VIE  K LY+VM+Y+    + D + A  +     A    +Q++  +++ H+  I+HRDLK  N+LLD + N+K+ADF FS       G  ++  T+CG+P Y  PE    L QG     + Y  P  D+WS GV L  ++S
Sbjct:  116 VRIMKVLNHPNIVKLFEVIEMEKTLYLVMEYSSGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKHIVHRDLKAENLLLDADMNIKIADFGFSNEFT--LGSKLD--TFCGSPPYAAPE----LFQG-----KKYDGPEVDVWSLGVILYTLVS 260
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 110.153 bits (274), Expect = 1.091e-25
Identity = 77/245 (31.43%), Postives = 120/245 (48.98%), Query Frame = 2 
Query:  887 VYRIKGSGTDRMFVLKGVPSADNKYLERNI--IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKL---KDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            VY+     TD++  +K V   +++ L   +  I  L  LNH  I+KY+G I     LYI+++Y  N SL   I      ++ N ++ Y  Q L GL++LH  G+IHRD+K  NILL  ++ VKLADF  S ++         A T  GT  ++ PEI  N          G +  +DIWS G T++ ML+       + +  I   + N+        S  +K  ++K   ++  KRP+   LL+
Sbjct:   39 VYKAINKHTDQVVAIKEVVYENDEELNDIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNS------SALTLAGTLNWMAPEILGN---------RGASTLSDIWSLGATVVEMLTKNPPYHNLTDANIYYAVENDTYYPPSSFSEPLKDFLSKCFVKNMYKRPTADQLLK 268
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Match: TPK3 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication [Source:SGD;Acc:S000001649])

HSP 1 Score: 105.531 bits (262), Expect = 4.551e-25
Identity = 65/202 (32.18%), Postives = 102/202 (50.50%), Query Frame = 2 
Query:  980 QFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLK-------DISNDMKAVITKTLKE 1564
            + L +++H  II+ +G  +  + +++VMDY     L   ++   +  N  A  Y+ +V   LE+LH   II+RDLKP NILLD   ++K+ DF F++ +      P   YT CGTP Y+ PE+          +T+ Y    D WSFGV +  ML+ +         K  E + N +LK       D  + +K +IT+ L E
Sbjct:  138 RMLSIVSHPFIIRMWGTFQDSQQVFMVMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV------PDVTYTLCGTPDYIAPEVV---------STKPYNKSVDWWSFGVLIYEMLAGYTPFYNSNTMKTYENILNAELKFPPFFHPDAQDLLKKLITRDLSE 324
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Match: TPK1 (cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; phosphorylates and inhibits Whi3p to promote G1/S phase passage; partially redundant with Tpk2p and Tpk3p; phosphorylates pre-Tom40p, which impairs its import into mitochondria under non-respiratory conditions; TPK1 has a paralog, TPK3, that arose from the whole genome duplication [Source:SGD;Acc:S000003700])

HSP 1 Score: 102.834 bits (255), Expect = 3.521e-24
Identity = 60/201 (29.85%), Postives = 103/201 (51.24%), Query Frame = 2 
Query:  986 LDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLK---DISNDMKAVITKTLKEDPTKR 1579
            L ++ H  II+ +G  +  + ++++MDY     L   ++   +  N  A  Y+ +V   LE+LH   II+RDLKP NILLD   ++K+ DF F++ +      P   YT CGTP Y+ PE+          +T+ Y    D WSFG+ +  ML+ +         K  E + N +L+     + D+K ++++ +  D ++R
Sbjct:  139 LSIVTHPFIIRMWGTFQDAQQIFMIMDYIEGGELFSLLRKSQRFPNPVAKFYAAEVCLALEYLHSKDIIYRDLKPENILLDKNGHIKITDFGFAKYV------PDVTYTLCGTPDYIAPEVV---------STKPYNKSIDWWSFGILIYEMLAGYTPFYDSNTMKTYEKILNAELRFPPFFNEDVKDLLSRLITRDLSQR 324
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Match: GIN4 (Protein kinase involved in bud growth and assembly of the septin ring; proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Hsl1p; GIN4 has a paralog, KCC4, that arose from the whole genome duplication [Source:SGD;Acc:S000002915])

HSP 1 Score: 104.76 bits (260), Expect = 7.991e-24
Identity = 80/239 (33.47%), Postives = 128/239 (53.56%), Query Frame = 2 
Query:  905 SGTDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKAD---PKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS---DFDT--------VKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKR 1579
            SGT    V    P A    +ER II  + LLNH  +++ Y V E+  +LY+V++YA    L + +      P+H    A R+ +Q++ G+ + H  GI+HRDLKP N+LLD + N+K+ADF  + +    EG+ +E  T CG+P+Y  PEI   +   G        + +D+WS GV L  +L+    FD         + +VQ G+  E+ +++   +IS + + +I K L  DP +R
Sbjct:   61 SGTS--IVGSTTPDALPYGIEREII-IMKLLNHPNVLRLYDVWETNTDLYLVLEYAEKGELFNLLVERGPLPEH---EAIRFFRQIIIGVSYCHALGIVHRDLKPENLLLDHKYNIKIADFGMAAL--ETEGKLLE--TSCGSPHYAAPEIVSGIPYQG--------FASDVWSCGVILFALLTGRLPFDEEDGNIRTLLLKVQKGEF-EMPSDD---EISREAQDLIRKILTVDPERR 277
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 102.449 bits (254), Expect = 2.942e-23
Identity = 76/266 (28.57%), Postives = 124/266 (46.62%), Query Frame = 2 
Query:  836 RGKTFKTGEKIASG-RVKVYRIKGSGTDRMFVLKGVPSADNKYLER-----NIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEIL-----ANEKLKDISNDMKAVITKTLKEDPTKRPSVTALL 1600
            RGK +  G  +  G   + ++IK    + +F  K V  A  K  +      + IQ    ++H  I+++    E   N+YI+++   N SL + +K            ++ Q+   ++++H   +IHRDLK GNI  D   N+K+ DF  + VL     E    YT CGTP Y+ PE+         G   G+++  DIWS GV L  +L      +      I E +     +  + K IS++ K +I   L  DP +RPS+T ++
Sbjct:   78 RGKDYHRGHFLGEGGFARCFQIKDDSGE-IFAAKTVAKASIKSEKTRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLA---NESERKYTICGTPNYIAPEVL-------MGKHSGHSFEVDIWSLGVMLYALLIGKPPFQARDVNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIM 332
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Match: EDO41410 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4G7])

HSP 1 Score: 119.013 bits (297), Expect = 3.512e-30
Identity = 78/224 (34.82%), Postives = 120/224 (53.57%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNAT---RYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS------DFDTVKQVQNGKISEILANEKL-KDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            I+F+    +ERI++YYG+     ++YI M+Y    S+ + IK   +H  LN +   +YS+Q+LEG+ +LH N I+HRD+K  NIL D   NVKLADF  S+ L+    +     +  GTPY++ PE+          N EGY   AD+WS G T++ ML+      DF+ +  +   KI+      +L  D+S D    +  TL+ +   RPS   LL+    +
Sbjct:   55 IEFMKAFRNERIVQYYGIETDDLHIYIFMEYLPGGSIHEHIK---QHGALNESLTRKYSRQILEGILYLHTNRIVHRDIKGANILRDLYGNVKLADFGASKRLQTIRSK-TGFRSVHGTPYWMAPEVI---------NGEGYGRKADVWSVGCTVVEMLTTKPPWADFEPMAALF--KIATQPTEPELPSDLSVDAVEFVRSTLRMNSKSRPSADELLRFSFVT 263
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Match: EDO33625 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRN4])

HSP 1 Score: 107.842 bits (268), Expect = 1.851e-25
Identity = 69/215 (32.09%), Postives = 115/215 (53.49%), Query Frame = 2 
Query:  953 NKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRV--LKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDF----DTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKR 1579
             K+L R I Q +  LNH  ++  +  IE+   +YI++D A N  L + I+++       A  +  Q+++ +E+LH  G++HRDLK  NILL+ ++ + ++DF F+R   +    G+   + T+CG+  Y PPEI R +   GT         ADIWS GV L  M+S      DT  +V   ++S  +   + K IS+++K ++ + L  D   R
Sbjct:  103 TKFLPREI-QVMKHLNHSNVVSLHEAIETSSRIYIILDLADNGDLLEYIRSNGAIPENEARLFYHQLVDAVEYLHNKGVVHRDLKCENILLNRDNRILISDFGFARTQHVMADTGKRRLSQTFCGSYAYAPPEILRGIAYDGT--------LADIWSLGVVLYTMVSASLPFDDTNLKVLLEQVSRDVVFSRRKKISDEVKDLVRRMLVADVKTR 308
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Match: EDO44594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV77])

HSP 1 Score: 106.301 bits (264), Expect = 6.065e-25
Identity = 74/222 (33.33%), Postives = 112/222 (50.45%), Query Frame = 2 
Query:  965 ERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFD---------TVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            E NI+  L L  H+ II+   V ES    ++V + A    L D +            R    + E ++++H + ++HRDLKP NILLD E NVK++DF F+  LK  EGE +     CGTP YL PE+   L      +  GYT   D+W+ GV L  +L  F           ++ + NGK +   ++ + +D+SND K +I K L   P +R + +  L+
Sbjct:   72 EVNIL--LSLQGHKNIIRLEDVFESTAFFFLVFEIAPKGELFDYLTEKVTLSEKQTRRIMLSIFEAVDYMHYHNVVHRDLKPENILLDEEINVKISDFGFAVELK--EGETLRE--LCGTPGYLAPEV---LQCSMFPDAPGYTKEVDMWACGVILYTLLCGFPPFWHRRQVVMLRNIMNGKYN--FSSPEWEDVSNDAKNLIKKLLVVHPKERITASDALK 282
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Match: EDO30712 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T001])

HSP 1 Score: 106.301 bits (264), Expect = 1.636e-24
Identity = 65/199 (32.66%), Postives = 101/199 (50.75%), Query Frame = 2 
Query:  851 KTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS 1447
            +T E IA   + + R+K + +       G    D+    R  I    +L    +IK+Y         Y+ ++Y+    L D+I+ D       A +Y KQ+L G+E+LH+ G+ HRD+KP N+LLD +DN+K+ DF F+ V +  +G        CGTP Y+ PE+         G  +    PADIWS G+ L+ ML+
Sbjct:   29 ETQEAIAVKIINIERVKAASSQ-----NGTSIQDDI---RKEICIHRMLQDVHVIKFYAQRVENSKQYLFLEYSSGGELFDRIEPDIGMPQAMAHKYFKQLLAGVEYLHRQGVTHRDIKPENLLLDSDDNLKITDFGFATVFRH-KGRERLLGKCCGTPPYVAPEV--------LGKMDYRAQPADIWSCGIVLVAMLA 210
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Match: EDO33129 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7ST31])

HSP 1 Score: 105.145 bits (261), Expect = 5.716e-24
Identity = 74/239 (30.96%), Postives = 114/239 (47.70%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLED----KIKADPKHVNLNATRYS------KQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLK--GPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKI-----------SEILANEKLKD---ISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            I  +   NHE ++ YY      + L+IVM      S+ D    +IK  P  V+             ++VL+GLE+ HKNG+IHRD+K GNILL  + +V+LADF  S  +   G   +P    T+ GTP ++ PE+   ++Q       GY + ADIWSFG+T I + +      +    K+            E  A+   +D    S   K +++  L+++P  RP    LL+   F
Sbjct:   63 IHAMSQCNHENVVNYYTSFVVRQELWIVMRLLNGGSMLDVIKQRIKQQPGLVDEGVLEEDIIATVLREVLKGLEYFHKNGLIHRDVKAGNILLATDGSVQLADFGVSSAISDYGDRTKPKMRKTFVGTPCWMAPEV---MEQ----QVHGYNHKADIWSFGITAIELATGTAPYAKFPAMKVLMLTLQNDPPRMETCADGSTRDYKKYSKVFKKMVSLCLQKEPANRPDANELLKNPFF 294
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Match: map3k3 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101169290])

HSP 1 Score: 115.546 bits (288), Expect = 9.807e-27
Identity = 76/216 (35.19%), Postives = 113/216 (52.31%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVI--ESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATR-YSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNG----KISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            IQ L  L+HERI++YYG +   S K L I M+Y    S++D++KA    +  N TR Y++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  S+ L+          +  GTPY++ PE+          + EGY   AD+WS G T++ ML++     + +      KI+    N  L   ++D        +  +   RPS   LL+
Sbjct:  404 IQLLKNLHHERIVQYYGCLRDHSEKTLTIFMEYMPGGSVKDQLKAY-GALTENVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVI---------SGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPLLPSHTSDQARDFIHCIFVEAKHRPSAEELLR 609
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Match: chek2 (checkpoint kinase 2 [Source:NCBI gene;Acc:101170645])

HSP 1 Score: 108.612 bits (270), Expect = 1.219e-24
Identity = 78/220 (35.45%), Postives = 111/220 (50.45%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNV---KLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTV-KQVQNGKISE-ILANE------KLKDISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            I+ L  ++H  +IK     ++  + +IV++      L +K+K+  +     A  Y  Q+L  + +LH NGIIHRDLKP NILL   ++V   K+ DF  SR+L+    E     T CGTP YL PE+  +       NT GY    D WS GV L   LS +    ++  N  +SE I+  E      K K ISN  K ++ K L  DP +R S+   LQ
Sbjct:  248 IKILQRVDHPCLIKTEDFYQTEDSYFIVLEMMEGGELFNKVKSQQQLKESVAKLYFYQMLCAVHYLHSNGIIHRDLKPENILLSSNEDVCLIKVTDFNQSRILE----EAALMRTLCGTPSYLAPEVFTH------ANTTGYGLAVDAWSLGVLLFVCLSGYAPFHEKFGNHSVSEQIIRGEFTMVPYKWKHISNQAKDMVRKLLVVDPKERMSIDEALQ 457
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Match: map3k2 (mitogen-activated protein kinase kinase kinase 2 [Source:NCBI gene;Acc:101160297])

HSP 1 Score: 108.997 bits (271), Expect = 1.384e-24
Identity = 76/220 (34.55%), Postives = 118/220 (53.64%), Query Frame = 2 
Query:  977 IQFLDLLNHERIIKYYGVIESG--KNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGP--EGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYML------SDFDTVKQVQNGKISEILANEKLK-DISNDMKAVITKTLKEDPTKRPSVTALLQ 1603
            IQ L  L HERI++YYG +     + L I M++    S++D++K+          RY++Q+LEG+ +LH N I+HRD+K  NIL D   NVKL DF  SR L+     G  +++ T  GTPY++ PE+          + EGY   ADIWS G T++ ML      ++F+ +  +   KI+    N +L   +S+  +  + +   E   +RPS   LL+
Sbjct:  440 IQLLKNLCHERIVQYYGCLRDTMERTLSIFMEHMPGGSIKDQLKSYGALTENVTRRYTRQILEGVSYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASRRLQTICLSGTGIKSVT--GTPYWMSPEVI---------SGEGYGRKADIWSVGCTVVEMLTQRPPWAEFEAMAAI--FKIATQPTNPELPVHVSDHCREFLRRIFVET-KQRPSADELLR 645
[Close]
BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Match: plk2b (polo like kinase 2 [Source:NCBI gene;Acc:101166557])

HSP 1 Score: 108.997 bits (271), Expect = 1.458e-24
Identity = 78/272 (28.68%), Postives = 124/272 (45.59%), Query Frame = 2 
Query:  836 RGKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVPSA------DNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPV--EAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYML---SDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            RGK    G     G  K Y +    T +++  K +P A        + ++R I +    LNH  ++ +Y   E  +N+YI+++Y   KSL   +KA           Y +Q++ GL++LH+  I+HRDLK GN  +     +K+ DF  +  L     EPV     T CGTP YL PE+          N +G+   +DIW+ G  +  ML     F+T    +  K            +S   K +I+  L + P  RP++  +L+ D F+
Sbjct:   53 RGKVLGKG-----GFAKCYEMTDLSTSKVYAAKIIPHARVSKPHQREKIDREI-ELHRALNHRHVVHFYHHFEDKENIYILLEYCSRKSLAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFVSESMELKVGDFGLAAKL-----EPVGNRRKTICGTPNYLSPEVL---------NKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYKCIREARYSLPSSLSPQAKQLISSLLAKIPEDRPNLDHILRHDFFT 304
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BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Match: map3k22 (mitogen-activated protein kinase kinase kinase 3 [Source:NCBI gene;Acc:101156127])

HSP 1 Score: 108.612 bits (270), Expect = 1.605e-24
Identity = 80/242 (33.06%), Postives = 121/242 (50.00%), Query Frame = 2 
Query:  758 LRRLISSMGVTCKGDTCDHKFCPTSIR-GKTFKTGEKIASGRVKVYRIKGSGTDRMFVLKGVP-SADNKYLERNI------IQFLDLLNHERIIKYYGVIES--GKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKG--PEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLS 1447
            LR L  S   +C+  T      P + R GK    G   A G  +VY    + T R    K VP   D +   + +      IQ L  L H+RI++YYG +     + L I +++    S++D++KA          RY++Q+L+G+ +LH N I+HRD+K  NIL D   NVKL DF  S+ ++     G  +++ T  GTPY++ PE+          N EGY   AD+WS   T++ ML+
Sbjct:  302 LRSLGRSADKSCQRGTAKSPRAPVNWRQGKLLGRG---AFG--EVYLCYDADTGRELAAKQVPFDPDCQETSKEVNALECEIQLLKNLRHDRIVQYYGCLRDLDQRKLTIFVEFMPGGSIKDQLKAYGALTEKVTRRYTRQILQGVSYLHSNMIVHRDIKGANILRDSSGNVKLGDFGASKRIQTICMSGTGIKSVT--GTPYWMSPEVI---------NGEGYGRKADVWSVACTVVEMLT 527
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BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Match: SMESG000017248.1 (SMESG000017248.1)

HSP 1 Score: 636.336 bits (1640), Expect = 0.000e+0
Identity = 331/502 (65.94%), Postives = 378/502 (75.30%), Query Frame = 2 
Query:  131 MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRV-KVYRIKGSGTDRMFVLKG--VPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHV-NLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQN---GKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            MSEFQAFVD+IKLGN ESFVQLYKP+YLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDI+IKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLL   CDID  DKA  AP DIA++ +  +LIK+ +E   ERPLR+LISSMGV C  DTCDHK CPTSIR K F+ G KI  G    VY+ + S T R+F +K   +   + + L+ NI  F ++LNHERIIKYYG I     LYIVM+Y VN SLEDKI      + N +  RYSKQVLEGLEHLHK GIIHRDLKPGNILLDGEDNVKLADF   RVL    G  +   T  G+ Y+  PEI       GTGN   Y  P DIWS G T+++ML+D + VK +++    ++SE+L   K   +  +M   +   L +DP +R +  ALL+L++F
Sbjct:    1 MSEFQAFVDAIKLGNLESFVQLYKPDYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIDIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKC-SDTCDHKLCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVNGSLEDKINKKKNDMKNDDIVRYSKQVLEGLEHLHKIGIIHRDLKPGNILLDGEDNVKLADFGIGRVLDKGIGSTIIPMTLKGSEYFTAPEI-------GTGNQ--YGTPVDIWSLGATVLFMLTDIENVKGLKDLVTPQMSELLDINK---VPKEMVTFLEYMLVKDPKRRWTAEALLKLEMF 489
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BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Match: SMESG000017245.1 (SMESG000017245.1)

HSP 1 Score: 556.599 bits (1433), Expect = 0.000e+0
Identity = 290/508 (57.09%), Postives = 367/508 (72.24%), Query Frame = 2 
Query:  131 MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKC----PNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRV-KVYRIKGSGTDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNA-----TRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNG---KISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIF 1615
            M+EF++F++++KLGN ESF +LYKPEYLNKKD Q W AIHYAC    + +LE LIS NC+INQ GG++G+ PIQ+AC      IV +LT+AECDIE +   + ++K      +E I++ILK RKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLL HNCDIDALDKA+QAP+DIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFC  +IR K+F  G++I  G    VY+ + SGT+RMF +K + ++    +E +I +F   LNHERIIKYYG +  G   YI+M+YA+N SL DK+      +  +       RYSKQ+LEGLEHLHK GIIHRDLKPGNILLDGEDNVKLADF   RVL+   G+  +     GTP ++  E++         +  GY  PADIWS G T+++ML D + +++++N    ++SE+L    L  +  +M   +   L +DP +R +  ALL+L++F
Sbjct:    1 MNEFESFLETVKLGNPESFEKLYKPEYLNKKDDQGWYAIHYACHEDQQAILENLISKNCNINQPGGQSGMRPIQVACYAEHDGIVEILTRAECDIEFEPERDPVIKIVEKYEDETIINILKARKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLAHNCDIDALDKANQAPEDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCSKTIRNKSFNGGKEIGHGSYGTVYKFQESGTERMFAVKTITNSKANSIEADINKFQHRLNHERIIKYYGAVSDGTQQYIIMEYAINGSLADKMNKKKNDMKNDMKNDDIVRYSKQILEGLEHLHKIGIIHRDLKPGNILLDGEDNVKLADFGIGRVLERETGK--DFTMNMGTPGFIAYEVQHK-------DENGYGPPADIWSLGATVLFML-DIENLEKLKNSVTPQMSELL---DLTKVPKEMVTFLEYMLVKDPKRRWTAEALLKLEMF 495
[Close]
BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Match: SMESG000017248.1 (SMESG000017248.1)

HSP 1 Score: 492.271 bits (1266), Expect = 4.231e-172
Identity = 243/319 (76.18%), Postives = 265/319 (83.07%), Query Frame = 2 
Query:  131 MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGRV-KVYRIKGSGTDRMFVLKG--VPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVN 1078
            MSEFQAFVD+IKLGN ESFVQLYKP+YLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDI+IKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLL   CDID  DKA  AP DIA++ +  +LIK+ +E   ERPLR+LISSMGV C  DTCDHK CPTSIR K F+ G KI  G    VY+ + S T R+F +K   +   + + L+ NI  F ++LNHERIIKYYG I     LYIVM+Y VN
Sbjct:    1 MSEFQAFVDAIKLGNLESFVQLYKPDYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIDIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLEQYCDIDPKDKAGLAPSDIAKDKKYTDLIKIFEENLPERPLRKLISSMGVKC-SDTCDHKLCPTSIRKKVFEGGTKIGHGTFGDVYKFQESVTGRLFAVKTMFINKVNAESLKVNINAFQNILNHERIIKYYGAITEDTKLYIVMEYVVN 318
[Close]
BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Match: SMESG000017252.1 (SMESG000017252.1)

HSP 1 Score: 481.485 bits (1238), Expect = 8.669e-170
Identity = 230/233 (98.71%), Postives = 232/233 (99.57%), Query Frame = 2 
Query:  131 MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPT 829
            MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLL HNCDIDALDKA+QAP+DIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPT
Sbjct:    1 MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEVLEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCLENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNRRPIHWAVEGGHTEIVKLLLAHNCDIDALDKANQAPEDIARNNRNDELIKVLDEERSERPLRRLISSMGVTCKGDTCDHKFCPT 233
[Close]
BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Match: SMESG000017249.1 (SMESG000017249.1)

HSP 1 Score: 476.478 bits (1225), Expect = 7.323e-168
Identity = 231/233 (99.14%), Postives = 231/233 (99.14%), Query Frame = 2 
Query:  920 MFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS 1618
            MFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNL QGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPS TALLQLDIFS
Sbjct:    1 MFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGVIESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHKNGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPYYLPPEIERNLHQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNGKISEILANEKLKDISNDMKAVITKTLKEDPTKRPSATALLQLDIFS 233
The following BLAST results are available for this feature:
BLAST of Protein kinase domain containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
MAP3K36.122e-2638.75mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K36.122e-2638.75mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K36.986e-2638.75mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.066e-2638.75mitogen-activated protein kinase kinase kinase 3 [... [more]
MAP3K37.419e-2638.75mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
air-11.724e-2228.40Aurora/Ipl1 Related kinase; Aurora/Ipl1-related pr... [more]
air-11.724e-2228.40Aurora/Ipl1 Related kinase; Aurora/Ipl1-related pr... [more]
gck-33.028e-2227.92Germinal center kinase 3 [Source:UniProtKB/Swiss-... [more]
gck-33.655e-2227.92Germinal center kinase 3 [Source:UniProtKB/Swiss-... [more]
gck-31.345e-2127.90Germinal center kinase 3 [Source:UniProtKB/Swiss-... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PhKgamma3.116e-2432.42gene:FBgn0011754 transcript:FBtr0343587[more]
grp3.141e-2435.20gene:FBgn0261278 transcript:FBtr0080886[more]
grp3.141e-2435.20gene:FBgn0261278 transcript:FBtr0080885[more]
grp3.141e-2435.20gene:FBgn0261278 transcript:FBtr0080884[more]
PhKgamma4.203e-2432.42gene:FBgn0011754 transcript:FBtr0090002[more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k31.817e-2640.37mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.090e-2640.37mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k32.095e-2634.40mitogen-activated protein kinase kinase kinase 3 [... [more]
si:ch211-197l9.58.694e-2531.58si:ch211-197l9.5 [Source:ZFIN;Acc:ZDB-GENE-091204-... [more]
chek29.464e-2534.68checkpoint kinase 2 [Source:NCBI gene;Acc:336998][more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
samd88.791e-2638.75sterile alpha motif domain containing 8 [Source:Xe... [more]
samd81.352e-2538.75sterile alpha motif domain containing 8 [Source:Xe... [more]
MAP3K23.616e-2539.38mitogen-activated protein kinase kinase kinase 2 [... [more]
MAP3K24.525e-2539.38mitogen-activated protein kinase kinase kinase 2 [... [more]
dennd1a9.410e-2532.42DENN domain containing 1A [Source:Xenbase;Acc:XB-G... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Map3k31.282e-2538.75mitogen-activated protein kinase kinase kinase 3 [... [more]
Map3k21.304e-2434.17mitogen-activated protein kinase kinase kinase 2 [... [more]
4921509C19Rik3.995e-2430.93RIKEN cDNA 4921509C19 gene [Source:MGI Symbol;Acc:... [more]
Gm141479.162e-2430.93predicted gene 14147 [Source:MGI Symbol;Acc:MGI:36... [more]
Gm141479.162e-2430.93predicted gene 14147 [Source:MGI Symbol;Acc:MGI:36... [more]
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BLAST of Protein kinase domain containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q39008|M3K1_ARATH1.217e-2530.86Mitogen-activated protein kinase kinase kinase 1 O... [more]
sp|Q99759|M3K3_HUMAN3.393e-2538.75Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q61084|M3K3_MOUSE8.968e-2538.75Mitogen-activated protein kinase kinase kinase 3 O... [more]
sp|Q54MH0|FHKD_DICDI1.278e-2434.06Probable serine/threonine-protein kinase fhkD OS=D... [more]
sp|Q84VQ3|CIPKQ_ARATH4.253e-2436.42CBL-interacting serine/threonine-protein kinase 26... [more]
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BLAST of Protein kinase domain containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A0H3YJG21.991e-4730.33Slc42a-1 OS=Schmidtea mediterranea OX=79327 GN=slc... [more]
K1PKP12.392e-2833.33Mitogen-activated protein kinase kinase kinase 2 O... [more]
A0A1A8JDE56.458e-2832.42CHK2 checkpoint homolog (Fragment) OS=Nothobranchi... [more]
A0A2C9U5561.368e-2625.38Uncharacterized protein OS=Manihot esculenta OX=39... [more]
B9S8G71.641e-2625.82Protein kinase, putative OS=Ricinus communis OX=39... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k34.712e-2639.75mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k34.712e-2639.75mitogen-activated protein kinase kinase kinase 3 [... [more]
map3k34.712e-2639.75mitogen-activated protein kinase kinase kinase 3 [... [more]
chek21.519e-2534.23checkpoint kinase 2 [Source:NCBI gene;Acc:10303496... [more]
sik11.117e-2433.49serine/threonine-protein kinase SIK2-like [Source:... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k22.014e-2637.67mitogen-activated protein kinase kinase kinase 2 [... [more]
NEK91.835e-2131.22NIMA related kinase 9 [Source:HGNC Symbol;Acc:HGNC... [more]
MARK35.053e-2136.08microtubule affinity regulating kinase 3 [Source:H... [more]
stk399.142e-2132.56serine threonine kinase 39 [Source:ZFIN;Acc:ZDB-GE... [more]
MARK31.361e-2035.44microtubule affinity regulating kinase 3 [Source:H... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
CDC151.091e-2531.43Protein kinase of the Mitotic Exit Network; locali... [more]
TPK34.551e-2532.18cAMP-dependent protein kinase catalytic subunit; p... [more]
TPK13.521e-2429.85cAMP-dependent protein kinase catalytic subunit; p... [more]
GIN47.991e-2433.47Protein kinase involved in bud growth and assembly... [more]
CDC52.942e-2328.57Polo-like kinase; controls targeting and activatio... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO414103.512e-3034.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO336251.851e-2532.09Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO445946.065e-2533.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO307121.636e-2432.66Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO331295.716e-2430.96Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Protein kinase domain containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
map3k39.807e-2735.19mitogen-activated protein kinase kinase kinase 3 [... [more]
chek21.219e-2435.45checkpoint kinase 2 [Source:NCBI gene;Acc:10117064... [more]
map3k21.384e-2434.55mitogen-activated protein kinase kinase kinase 2 [... [more]
plk2b1.458e-2428.68polo like kinase 2 [Source:NCBI gene;Acc:101166557... [more]
map3k221.605e-2433.06mitogen-activated protein kinase kinase kinase 3 [... [more]
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BLAST of Protein kinase domain containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000017248.10.000e+065.94SMESG000017248.1[more]
SMESG000017245.10.000e+057.09SMESG000017245.1[more]
SMESG000017248.14.231e-17276.18SMESG000017248.1[more]
SMESG000017252.18.669e-17098.71SMESG000017252.1[more]
SMESG000017249.17.323e-16899.14SMESG000017249.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020244 ID=SMED30020244|Name=Protein kinase domain containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1731bp
TTATAATCAACATTTATTTTTACTTTTAAATTTCGGAAGTTGCGGAGTTT
TATCAAAATTCTAAAAATTCTTTCTGTTCAGATAAATTTTGATTTATTTC
CATCTTGTTTGATCTGAATCAGCGGATAAAATGAGCGAATTCCAAGCATT
TGTCGATTCCATCAAATTGGGAAATTTTGAATCATTTGTGCAACTTTACA
AACCCGAATATTTAAACAAAAAGGATAAGCAGTCATGGTGCGCAATCCAT
TATGCGTGCCAATTTGGCCACAAAGAGGTTTTAGAAAAGCTGATCAGTTG
GAATTGTGATATCAACCAAATGGGGGGACGGAACGGATTGCTTCCGATTC
AGCTTGCCTGCTCGGAAGGCCAGACGGATATAGTAGCACTATTGACGCAA
GCAGAGTGCGATATTGAAATAAAATGTCTGGAGAACTCGCTAATGAAATG
TCCGAATGAGAAAATTGTGGACATTCTCAAAGGGAGGAAATTCTTGCTTG
CTTGCAAAAAGGGCGACCTTGAAACGGTCCGTTCAATGCTTACAGATGTC
AACGTGGAATATTGTGACAAGGACAACAGACGGCCGATTCACTGGGCGGT
GGAGGGGGGCCACACGGAAATCGTCAAGTTACTGCTGGTGCATAATTGTG
ACATTGACGCACTAGATAAAGCGGACCAAGCTCCGAAGGACATTGCTAGA
AACAACAGAAATGATGAGCTCATCAAGGTTTTGGACGAAGAACGTTCAGA
ACGTCCACTAAGGAGATTGATTTCCAGCATGGGGGTGACATGCAAGGGTG
ACACATGCGACCATAAGTTCTGCCCTACATCAATTCGCGGGAAAACATTT
AAGACTGGAGAAAAGATTGCATCAGGAAGAGTTAAGGTTTACAGAATTAA
AGGATCTGGAACTGACAGGATGTTTGTGTTAAAAGGGGTGCCTTCAGCGG
ATAATAAGTACTTAGAACGTAATATTATTCAATTTCTGGACCTGCTGAAC
CACGAAAGAATAATCAAATATTATGGAGTTATTGAATCGGGAAAGAATTT
ATACATCGTTATGGACTATGCTGTCAACAAATCTCTCGAGGACAAAATTA
AAGCAGATCCAAAACATGTCAACCTCAATGCTACCCGATATAGCAAGCAG
GTCCTTGAAGGTCTGGAGCACCTGCATAAAAATGGCATCATCCATCGGGA
CTTGAAGCCGGGAAATATTTTGCTGGATGGAGAGGATAATGTAAAATTAG
CAGATTTTGAGTTTAGCCGGGTTCTAAAGGGCCCGGAAGGGGAACCAGTG
GAGGCTTACACGTATTGTGGGACCCCATATTACTTGCCTCCGGAAATTGA
GAGGAATTTAGATCAAGGTGGTACTGGGAACACAGAGGGATACACTTATC
CTGCTGACATTTGGTCATTTGGAGTTACACTTATTTATATGCTCTCCGAT
TTCGATACCGTGAAGCAAGTTCAGAACGGTAAAATATCGGAGATATTAGC
AAATGAAAAGTTGAAAGATATTTCCAATGACATGAAAGCTGTCATAACAA
AAACCCTAAAGGAGGATCCGACAAAGCGGCCATCGGTCACAGCCTTATTG
CAATTGGATATATTTAGTTGACTGTCCATTGGTGGACCTCCCGTTGATTG
ACAAATGGAGCTTTTTGACCCTTTCCTTAATCCATTGAAATGTCATGTCA
AATAAAATTATTTGATTCAAAAAAAAAGATC
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protein sequence of SMED30020244-orf-1

>SMED30020244-orf-1 ID=SMED30020244-orf-1|Name=SMED30020244-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=497bp
MSEFQAFVDSIKLGNFESFVQLYKPEYLNKKDKQSWCAIHYACQFGHKEV
LEKLISWNCDINQMGGRNGLLPIQLACSEGQTDIVALLTQAECDIEIKCL
ENSLMKCPNEKIVDILKGRKFLLACKKGDLETVRSMLTDVNVEYCDKDNR
RPIHWAVEGGHTEIVKLLLVHNCDIDALDKADQAPKDIARNNRNDELIKV
LDEERSERPLRRLISSMGVTCKGDTCDHKFCPTSIRGKTFKTGEKIASGR
VKVYRIKGSGTDRMFVLKGVPSADNKYLERNIIQFLDLLNHERIIKYYGV
IESGKNLYIVMDYAVNKSLEDKIKADPKHVNLNATRYSKQVLEGLEHLHK
NGIIHRDLKPGNILLDGEDNVKLADFEFSRVLKGPEGEPVEAYTYCGTPY
YLPPEIERNLDQGGTGNTEGYTYPADIWSFGVTLIYMLSDFDTVKQVQNG
KISEILANEKLKDISNDMKAVITKTLKEDPTKRPSVTALLQLDIFS*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000034epidermis
PLANA:0000070intestinal phagocyte
PLANA:0002075pigment cell
PLANA:0002089reproductive organ
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR036770Ankyrin_rpt-contain_sf
IPR000719Prot_kinase_dom
IPR002110Ankyrin_rpt
IPR020683Ankyrin_rpt-contain_dom
IPR008271Ser/Thr_kinase_AS
IPR011009Kinase-like_dom_sf
Vocabulary: biological process
TermDefinition
GO:0006468protein phosphorylation
GO:0016310phosphorylation
Vocabulary: molecular function
TermDefinition
GO:0004672protein kinase activity
GO:0005524ATP binding
GO:0005515protein binding
GO:0016301kinase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000719Protein kinase domainSMARTSM00220serkin_6coord: 240..495
e-value: 4.2E-60
score: 215.6
IPR000719Protein kinase domainPFAMPF00069Pkinasecoord: 241..493
e-value: 7.4E-50
score: 169.8
IPR000719Protein kinase domainPROSITEPS50011PROTEIN_KINASE_DOMcoord: 240..495
score: 37.601
IPR002110Ankyrin repeatSMARTSM00248ANK_2acoord: 148..177
e-value: 7.5E-5
score: 32.1
coord: 34..63
e-value: 34.0
score: 13.3
coord: 68..97
e-value: 0.49
score: 19.4
IPR002110Ankyrin repeatPROSITEPS50088ANK_REPEATcoord: 148..180
score: 12.609
NoneNo IPR availablePIRSFPIRSF000654ILKcoord: 20..113
e-value: 5.1E-6
score: 23.0
coord: 98..493
e-value: 4.2E-42
score: 142.0
NoneNo IPR availableGENE3DG3DSA:1.10.510.10coord: 237..496
e-value: 1.7E-59
score: 203.2
NoneNo IPR availablePANTHERPTHR44167FAMILY NOT NAMEDcoord: 228..493
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 3..117
e-value: 5.1E-16
score: 60.4
IPR036770Ankyrin repeat-containing domain superfamilyGENE3DG3DSA:1.25.40.20coord: 119..208
e-value: 4.2E-19
score: 70.8
IPR036770Ankyrin repeat-containing domain superfamilySUPERFAMILYSSF48403Ankyrin repeatcoord: 10..201
IPR020683Ankyrin repeat-containing domainPFAMPF12796Ank_2coord: 123..177
e-value: 6.1E-9
score: 36.3
coord: 14..98
e-value: 3.1E-8
score: 34.1
IPR020683Ankyrin repeat-containing domainPROSITEPS50297ANK_REP_REGIONcoord: 28..201
score: 19.943
IPR008271Serine/threonine-protein kinase, active sitePROSITEPS00108PROTEIN_KINASE_STcoord: 353..365
IPR011009Protein kinase-like domain superfamilySUPERFAMILYSSF56112Protein kinase-like (PK-like)coord: 238..495