Insulin-degrading enzyme

Overview


Name	Insulin-degrading enzyme
Smed ID	SMED30020179
Length (bp)	609

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Insulin-degrading enzyme (SMED30020179) t-SNE clustered cells

Violin plots show distribution of expression levels for Insulin-degrading enzyme (SMED30020179) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Insulin-degrading enzyme (SMED30020179) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Insulin-degrading enzyme (SMED30020179) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30020179

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30020179	h1SMcG0004127	dd_Smed_v4_9500_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30020179	h1SMcG0004127	dd_Smed_v4_9500_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30020179	h1SMcG0004127	dd_Smed_v4_9500_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30020179	h1SMcG0004127	dd_Smed_v4_9500_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30020179	h1SMcG0004127	dd_Smed_v4_9500_1_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: IDE (insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381])

HSP 1 Score: 224.557 bits (571), Expect = 1.198e-67
Identity = 105/202 (51.98%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VR+ LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H+K
Sbjct:   98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299

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Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VR+ LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H+K
Sbjct:   98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299

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BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: IDE (insulin degrading enzyme [Source:HGNC Symbol;Acc:HGNC:5381])

HSP 1 Score: 197.978 bits (502), Expect = 2.889e-63
Identity = 92/174 (52.87%), Postives = 127/174 (72.99%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWV 524
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VR+ LL FH  YYSSN+M++CVL +E LD L   V
Sbjct:   84 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLV 257

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BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: NRDC (nardilysin convertase [Source:HGNC Symbol;Acc:HGNC:7995])

HSP 1 Score: 158.303 bits (399), Expect = 3.480e-44
Identity = 86/192 (44.79%), Postives = 118/192 (61.46%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWN 578
            +DP ++ GLAHF EHMVFMGS KY +EN +  +L ++ G  NA T  E T F F+++ +  KEA+D +AQFFI PL    A DRE++AV+SE++     D  R   L   L+   H   KF  GN +TLK +P KN I+    L  F  +YYSS+ M+L V SKE LD L+KWV E+FS + N  +  P++ 
Sbjct:  223 ADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFG 414

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BLAST of Insulin-degrading enzyme vs. Ensembl Human
Match: NRDC (nardilysin convertase [Source:HGNC Symbol;Acc:HGNC:7995])

HSP 1 Score: 158.303 bits (399), Expect = 3.516e-44
Identity = 86/192 (44.79%), Postives = 118/192 (61.46%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWN 578
            +DP ++ GLAHF EHMVFMGS KY +EN +  +L ++ G  NA T  E T F F+++ +  KEA+D +AQFFI PL    A DRE++AV+SE++     D  R   L   L+   H   KF  GN +TLK +P KN I+    L  F  +YYSS+ M+L V SKE LD L+KWV E+FS + N  +  P++ 
Sbjct:  159 ADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNIDTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFG 350

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BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5773295:5776951:-1 gene:WBGene00018426.1 transcript:F44E7.4d.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4)

HSP 1 Score: 224.172 bits (570), Expect = 6.089e-68
Identity = 107/201 (53.23%), Postives = 144/201 (71.64%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVEL-FSPVVNKHVEIPHWNSHPWTQDHV 605
            DPW + GLAHFCEHM+F+G+ KY  EN Y+K+L+ + G  NAYTSS+HTN++F++KP++L  A+D F QFF+SP FTESAT+RE+ AV+SEH  N+  D+ R LQ+DR  S   HDY KF TGN +TL ED  K GI  R+ALL FH K+YSS+IM+ C++ KEPL+VL+ ++  L F  + NK VE   W   P+  D +
Sbjct:  120 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 320

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BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776953:-1 gene:WBGene00018426.1 transcript:F44E7.4c.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4)

HSP 1 Score: 224.172 bits (570), Expect = 6.794e-68
Identity = 107/201 (53.23%), Postives = 144/201 (71.64%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVEL-FSPVVNKHVEIPHWNSHPWTQDHV 605
            DPW + GLAHFCEHM+F+G+ KY  EN Y+K+L+ + G  NAYTSS+HTN++F++KP++L  A+D F QFF+SP FTESAT+RE+ AV+SEH  N+  D+ R LQ+DR  S   HDY KF TGN +TL ED  K GI  R+ALL FH K+YSS+IM+ C++ KEPL+VL+ ++  L F  + NK VE   W   P+  D +
Sbjct:   61 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 261

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BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776655:-1 gene:WBGene00018426.1 transcript:F44E7.4c.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4)

HSP 1 Score: 224.172 bits (570), Expect = 6.794e-68
Identity = 107/201 (53.23%), Postives = 144/201 (71.64%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVEL-FSPVVNKHVEIPHWNSHPWTQDHV 605
            DPW + GLAHFCEHM+F+G+ KY  EN Y+K+L+ + G  NAYTSS+HTN++F++KP++L  A+D F QFF+SP FTESAT+RE+ AV+SEH  N+  D+ R LQ+DR  S   HDY KF TGN +TL ED  K GI  R+ALL FH K+YSS+IM+ C++ KEPL+VL+ ++  L F  + NK VE   W   P+  D +
Sbjct:   61 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 261

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772831:5776951:-1 gene:WBGene00018426.1 transcript:F44E7.4b.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4)

HSP 1 Score: 224.172 bits (570), Expect = 8.124e-68
Identity = 107/201 (53.23%), Postives = 144/201 (71.64%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVEL-FSPVVNKHVEIPHWNSHPWTQDHV 605
            DPW + GLAHFCEHM+F+G+ KY  EN Y+K+L+ + G  NAYTSS+HTN++F++KP++L  A+D F QFF+SP FTESAT+RE+ AV+SEH  N+  D+ R LQ+DR  S   HDY KF TGN +TL ED  K GI  R+ALL FH K+YSS+IM+ C++ KEPL+VL+ ++  L F  + NK VE   W   P+  D +
Sbjct:  120 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 320

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Match: F44E7.4 (pep chromosome:WBcel235:V:5772832:5777034:-1 gene:WBGene00018426.1 transcript:F44E7.4b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F44E7.4)

HSP 1 Score: 224.172 bits (570), Expect = 8.124e-68
Identity = 107/201 (53.23%), Postives = 144/201 (71.64%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVEL-FSPVVNKHVEIPHWNSHPWTQDHV 605
            DPW + GLAHFCEHM+F+G+ KY  EN Y+K+L+ + G  NAYTSS+HTN++F++KP++L  A+D F QFF+SP FTESAT+RE+ AV+SEH  N+  D+ R LQ+DR  S   HDY KF TGN +TL ED  K GI  R+ALL FH K+YSS+IM+ C++ KEPL+VL+ ++  L F  + NK VE   W   P+  D +
Sbjct:  120 DPWELPGLAHFCEHMLFLGTAKYPSENEYSKFLAAHAGSSNAYTSSDHTNYHFDVKPDQLPGALDRFVQFFLSPQFTESATEREVCAVDSEHSNNLNNDLWRFLQVDRSRSKPGHDYGKFGTGNKQTLLEDARKKGIEPRDALLQFHKKWYSSDIMTCCIVGKEPLNVLESYLGTLEFDAIENKKVERKVWEEFPYGPDQL 320

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BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: Ide (gene:FBgn0001247 transcript:FBtr0273273)

HSP 1 Score: 221.09 bits (562), Expect = 1.100e-66
Identity = 106/200 (53.00%), Postives = 141/200 (70.50%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDH 602
            SDP N+ GLAHFCEHM+F+G+EKY  EN Y  YLSQ+ G  NA T    T ++F + P+KL  A+D FAQFFI+PLFT SAT+RE+ AVNSEHEKN+  D+ R  Q++RHL+  +H Y KF +GN  TL E P    I+VR+ LL FH ++YS+NIM L V+ KE LD L+  V+E FS + NK+V++P W  HP+ ++ 
Sbjct:   71 SDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEER 270

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BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: Nrd1 (gene:FBgn0030344 transcript:FBtr0073601)

HSP 1 Score: 124.02 bits (310), Expect = 1.829e-32
Identity = 70/193 (36.27%), Postives = 110/193 (56.99%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNS 581
            ++P    GLAHF EHM+FMGSEKY +ENI+  ++ +  G  NA T  E T FYFE+  + L  ++D F     +PL  + A  RE  AV+SE ++ +  D  R  QL   L+ +   +  FA GN+K+LKE+ D   ++  + L     ++Y +N M +C+ ++ P+D L+  VV  FS + +  V+ P  +S
Sbjct:  148 AEPTKYQGLAHFLEHMIFMGSEKYPKENIFDAHIKKCGGFANANTDCEDTLFYFEVAEKHLDSSLDYFTALMKAPLMKQEAMQRERSAVDSEFQQILQDDETRRDQLLASLATKGFPHGTFAWGNMKSLKENVDDAELH--KILHEIRKEHYGANRMYVCLQARLPIDELESLVVRHFSGIPHNEVKAPDLSS 338

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BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: CG10588 (gene:FBgn0037037 transcript:FBtr0078284)

HSP 1 Score: 104.76 bits (260), Expect = 6.646e-26
Identity = 60/164 (36.59%), Postives = 91/164 (55.49%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSK 494
            S+P    GLAHF EHM+FMGSEK+  EN +  +++++ G  NA+T +E T FYFE+    L   +D+F     +PL    A  RE  AV SE E+    D  R  Q+   L+   + +  F+ GN KTLKE  D + ++  + L  F+  +Y SN M + + ++
Sbjct:  106 SEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTLKEGVDDSSLH--KELHKFYRDHYGSNRMVVALQAQ 267

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: CG10588 (gene:FBgn0037037 transcript:FBtr0346528)

HSP 1 Score: 104.76 bits (260), Expect = 6.646e-26
Identity = 60/164 (36.59%), Postives = 91/164 (55.49%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSK 494
            S+P    GLAHF EHM+FMGSEK+  EN +  +++++ G  NA+T +E T FYFE+    L   +D+F     +PL    A  RE  AV SE E+    D  R  Q+   L+   + +  F+ GN KTLKE  D + ++  + L  F+  +Y SN M + + ++
Sbjct:  106 SEPQQYQGLAHFVEHMIFMGSEKFPVENEFDSFVTKSGGFSNAHTENEETCFYFELDQTHLDRGMDLFMNLMKAPLMLPDAMSRERSAVQSEFEQTHMRDEVRRDQILASLASEGYPHGTFSWGNYKTLKEGVDDSSLH--KELHKFYRDHYGSNRMVVALQAQ 267

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BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Match: UQCR-C1 (gene:FBgn0038271 transcript:FBtr0083000)

HSP 1 Score: 49.2914 bits (116), Expect = 8.039e-7
Identity = 31/100 (31.00%), Postives = 50/100 (50.00%), Query Frame = 3

Query:   24 GLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGD-FNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQ 320
            G+AHF EHM F G+ K  + ++  +   +N G   NAYTS E T FY +   + + +A++I A    +    E+   RE   +  E +     ++  NLQ
Sbjct:   81 GVAHFLEHMAFKGTAKRSQTDLELEV--ENLGAHLNAYTSREQTVFYAKCLSKDVPKAVEILADIIQNSKLGEAEIARERSVILREMQ-----EVESNLQ 173

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BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: ide (insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE-070410-85])

HSP 1 Score: 228.409 bits (581), Expect = 2.963e-69
Identity = 106/202 (52.48%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P + GI++RE LL FH  YYSSN+M LCVL +E LD L   VV+LF  V NK+V +P + +HP+ ++H++
Sbjct:   77 SDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPKHPFSKFGTGNKLTLETRPSQQGIDIREELLKFHSTYYSSNLMGLCVLGRETLDELTSMVVKLFGEVENKNVPVPEFPTHPFQEEHLR 278

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422])

HSP 1 Score: 159.458 bits (402), Expect = 1.779e-45
Identity = 84/183 (45.90%), Postives = 116/183 (63.39%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            SDP ++ GLAHF EHMVFMGSEKY  EN +  +L ++ G  NA T  E T F F+++ + L+EA+D +AQFFI PL    A DRE++AV+SE++    +D  R   L   L+   H   KF  GN +TLK++P +  IN  E L +F  +YYS+  M+L V SKE LD L++WV E+F  + N
Sbjct:  127 SDPADLPGLAHFLEHMVFMGSEKYPVENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKYLREALDRWAQFFICPLMIPDAVDREVEAVDSEYQMAQPLDSNRKEMLFGSLAKAGHPMSKFFWGNAQTLKQEPREKKINTYERLRDFWRRYYSAQYMTLAVQSKETLDTLEEWVREIFVQIPN 309

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1a (nardilysin a (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-070912-417])

HSP 1 Score: 160.999 bits (406), Expect = 3.000e-45
Identity = 86/183 (46.99%), Postives = 118/183 (64.48%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            SDP ++ GLAHF EHMVFMGSEKY  EN +  +L ++ G  NA T  E T F F+++ ++ KEA+D +AQFFI PL  E A DRE++AV+SE++     D  R   L   L+  +H   KF  GN +TLK +P +  INV + L  F  ++YS++ M+L V SKE LD L++WV E+FS V N
Sbjct:  158 SDPNDLPGLAHFLEHMVFMGSEKYPSENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKRFKEALDRWAQFFICPLMIEDAIDREVEAVDSEYQLAKPSDSHRKEMLFGSLAKPDHPMSKFCWGNAQTLKTEPKEKNINVYKRLREFWKRHYSAHYMTLAVQSKESLDTLEEWVREIFSQVPN 340

[Close]

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            SDP ++ GLAHF EHMVFMGSEKY  EN +  +L ++ G  NA T  E T F F+++ ++ KEA+D +AQFFI PL  E A DRE++AV+SE++     D  R   L   L+  +H   KF  GN +TLK +P +  INV + L  F  ++YS++ M+L V SKE LD L++WV E+FS V N
Sbjct:  158 SDPNDLPGLAHFLEHMVFMGSEKYPSENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKRFKEALDRWAQFFICPLMIEDAIDREVEAVDSEYQLAKPSDSHRKEMLFGSLAKPDHPMSKFCWGNAQTLKTEPKEKNINVYKRLREFWKRHYSAHYMTLAVQSKESLDTLEEWVREIFSQVPN 340

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422])

HSP 1 Score: 159.073 bits (401), Expect = 1.143e-44
Identity = 84/183 (45.90%), Postives = 116/183 (63.39%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            SDP ++ GLAHF EHMVFMGSEKY  EN +  +L ++ G  NA T  E T F F+++ + L+EA+D +AQFFI PL    A DRE++AV+SE++    +D  R   L   L+   H   KF  GN +TLK++P +  IN  E L +F  +YYS+  M+L V SKE LD L++WV E+F  + N
Sbjct:  127 SDPADLPGLAHFLEHMVFMGSEKYPVENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKYLREALDRWAQFFICPLMIPDAVDREVEAVDSEYQMAQPLDSNRKEMLFGSLAKAGHPMSKFFWGNAQTLKQEPREKKINTYERLRDFWRRYYSAQYMTLAVQSKETLDTLEEWVREIFVQIPN 309

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154])

HSP 1 Score: 226.483 bits (576), Expect = 2.195e-68
Identity = 104/202 (51.49%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI++R+ LL FH  YYSSN+MSLCVL +E LD L + +++LF+ V NK V +P +  HP+ ++H++
Sbjct:   68 SDPNNIAGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPTQQGIDIRQELLKFHSTYYSSNLMSLCVLGRESLDSLTELIIKLFAEVENKIVPLPEFPDHPFQEEHLR 269

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154])

HSP 1 Score: 226.483 bits (576), Expect = 2.578e-68
Identity = 104/202 (51.49%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI++R+ LL FH  YYSSN+MSLCVL +E LD L + +++LF+ V NK V +P +  HP+ ++H++
Sbjct:   90 SDPNNIAGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPTQQGIDIRQELLKFHSTYYSSNLMSLCVLGRESLDSLTELIIKLFAEVENKIVPLPEFPDHPFQEEHLR 291

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154])

HSP 1 Score: 226.098 bits (575), Expect = 2.740e-68
Identity = 104/202 (51.49%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI++R+ LL FH  YYSSN+MSLCVL +E LD L + +++LF+ V NK V +P +  HP+ ++H++
Sbjct:   82 SDPNNIAGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPTQQGIDIRQELLKFHSTYYSSNLMSLCVLGRESLDSLTELIIKLFAEVENKIVPLPEFPDHPFQEEHLR 283

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154])

HSP 1 Score: 226.098 bits (575), Expect = 2.844e-68
Identity = 104/202 (51.49%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI++R+ LL FH  YYSSN+MSLCVL +E LD L + +++LF+ V NK V +P +  HP+ ++H++
Sbjct:   88 SDPNNIAGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPTQQGIDIRQELLKFHSTYYSSNLMSLCVLGRESLDSLTELIIKLFAEVENKIVPLPEFPDHPFQEEHLR 289

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Match: IDE (insulin degrading enzyme [Source:NCBI gene;Acc:100490154])

HSP 1 Score: 226.098 bits (575), Expect = 3.045e-68
Identity = 104/202 (51.49%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI++R+ LL FH  YYSSN+MSLCVL +E LD L + +++LF+ V NK V +P +  HP+ ++H++
Sbjct:   91 SDPNNIAGLAHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPTQQGIDIRQELLKFHSTYYSSNLMSLCVLGRESLDSLTELIIKLFAEVENKIVPLPEFPDHPFQEEHLR 292

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Ide (insulin degrading enzyme [Source:MGI Symbol;Acc:MGI:96412])

HSP 1 Score: 222.631 bits (566), Expect = 3.406e-67
Identity = 104/202 (51.49%), Postives = 147/202 (72.77%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF  S  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VRE LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H++
Sbjct:   66 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLR 267

[Close]

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF  S  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VRE LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H++
Sbjct:   66 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLR 267

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386])

HSP 1 Score: 157.918 bits (398), Expect = 3.868e-44
Identity = 85/192 (44.27%), Postives = 119/192 (61.98%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWN 578
            +DP ++ GLAHF EHMVFMGS KY +EN +  +L ++ G  NA T  E T F F+++ +  KEA+D +AQFFI PL    A DRE++AV+SE++     D  R   L   L+   H   KF  GN +TLK +P KN I+    L  F  +YYS++ M+L V SKE LD L+KWV E+FS + N  +  P+++
Sbjct:  302 ADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFS 493

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386])

HSP 1 Score: 157.532 bits (397), Expect = 4.312e-44
Identity = 85/192 (44.27%), Postives = 119/192 (61.98%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWN 578
            +DP ++ GLAHF EHMVFMGS KY +EN +  +L ++ G  NA T  E T F F+++ +  KEA+D +AQFFI PL    A DRE++AV+SE++     D  R   L   L+   H   KF  GN +TLK +P KN I+    L  F  +YYS++ M+L V SKE LD L+KWV E+FS + N  +  P+++
Sbjct:  234 ADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFS 425

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Match: Nrd1 (nardilysin, N-arginine dibasic convertase, NRD convertase 1 [Source:MGI Symbol;Acc:MGI:1201386])

HSP 1 Score: 138.658 bits (348), Expect = 5.666e-39
Identity = 76/177 (42.94%), Postives = 107/177 (60.45%), Query Frame = 3

Query:   48 MVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWN 578
            MVFMGS KY +EN +  +L ++ G  NA T  E T F F+++ +  KEA+D +AQFFI PL    A DRE++AV+SE++     D  R   L   L+   H   KF  GN +TLK +P KN I+    L  F  +YYS++ M+L V SKE LD L+KWV E+FS + N  +  P+++
Sbjct:    1 MVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFS 177

[Close]

BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|Q24K02|IDE_BOVIN (Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=IDE PE=2 SV=1)

HSP 1 Score: 224.942 bits (572), Expect = 4.953e-67
Identity = 105/202 (51.98%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VR+ LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H+K
Sbjct:   98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299

[Close]

BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P14735|IDE_HUMAN (Insulin-degrading enzyme OS=Homo sapiens OX=9606 GN=IDE PE=1 SV=4)

HSP 1 Score: 224.557 bits (571), Expect = 5.755e-67
Identity = 105/202 (51.98%), Postives = 148/202 (73.27%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VR+ LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H+K
Sbjct:   98 SDPPNIAGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVRQELLKFHSAYYSSNLMAVCVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299

[Close]

BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P35559|IDE_RAT (Insulin-degrading enzyme OS=Rattus norvegicus OX=10116 GN=Ide PE=1 SV=1)

HSP 1 Score: 223.402 bits (568), Expect = 1.611e-66
Identity = 105/202 (51.98%), Postives = 147/202 (72.77%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF  S  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VRE LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H+K
Sbjct:   98 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLFDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLK 299

[Close]

BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|P22817|IDE_DROME (Insulin-degrading enzyme OS=Drosophila melanogaster OX=7227 GN=Ide PE=1 SV=4)

HSP 1 Score: 221.09 bits (562), Expect = 1.103e-65
Identity = 106/200 (53.00%), Postives = 141/200 (70.50%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDH 602
            SDP N+ GLAHFCEHM+F+G+EKY  EN Y  YLSQ+ G  NA T    T ++F + P+KL  A+D FAQFFI+PLFT SAT+RE+ AVNSEHEKN+  D+ R  Q++RHL+  +H Y KF +GN  TL E P    I+VR+ LL FH ++YS+NIM L V+ KE LD L+  V+E FS + NK+V++P W  HP+ ++ 
Sbjct:   71 SDPTNLPGLAHFCEHMLFLGTEKYPHENGYTTYLSQSGGSSNAATYPLMTKYHFHVAPDKLDGALDRFAQFFIAPLFTPSATEREINAVNSEHEKNLPSDLWRIKQVNRHLAKPDHAYSKFGSGNKTTLSEIPKSKNIDVRDELLKFHKQWYSANIMCLAVIGKESLDELEGMVLEKFSEIENKNVKVPGWPRHPYAEER 270

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BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Match: sp|Q9JHR7|IDE_MOUSE (Insulin-degrading enzyme OS=Mus musculus OX=10090 GN=Ide PE=1 SV=1)

HSP 1 Score: 220.705 bits (561), Expect = 1.876e-65
Identity = 103/202 (50.99%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GL+HFCEHM+F+G++KY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PL   S  DRE+ AV+SEHEKN+  D  R  QL++   +  H + KF TGN  TL+  P++ GI+VRE LL FH  YYSSN+M++CVL +E LD L   VV+LFS V NK+V +P +  HP+ ++H++
Sbjct:   98 SDPPNIPGLSHFCEHMLFLGTKKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLEGALDRFAQFFLCPLLDASCKDREVNAVDSEHEKNVMNDAWRLFQLEKATGNPKHPFSKFGTGNKYTLETRPNQEGIDVREELLKFHSTYYSSNLMAICVLGRESLDDLTNLVVKLFSEVENKNVPLPEFPEHPFQEEHLR 299

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BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A2R7VZW3 (Uncharacterized protein (Fragment) OS=Oncopeltus fasciatus OX=7536 GN=OFAS_OFAS002873 PE=4 SV=1)

HSP 1 Score: 236.884 bits (603), Expect = 8.433e-75
Identity = 117/201 (58.21%), Postives = 148/201 (73.63%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHV 605
            SDP ++ GLAHFCEHM+F+G+EKY  EN Y+KYLS++ G  NA+T+ EHT F+F++ PE  K A+D FAQFFISPLFTE+ TDRE+ AVNSEHEKNI  D  R  QL+R LS   H Y KF TGN  TL   P + GINVR  LL FH K+YS+NIM+L VL K+ LD L+++VV LFS VVNK+V  P WN  P++++ +
Sbjct:   93 SDPDHLPGLAHFCEHMLFLGTEKYPLENEYSKYLSEHGGSSNAHTTHEHTTFFFDVTPEHFKGALDRFAQFFISPLFTENVTDREVNAVNSEHEKNIVNDAWRLNQLERSLSRPGHPYKKFGTGNKATLDTIPKQKGINVRNELLAFHQKWYSANIMTLAVLGKDSLDDLEEFVVTLFSAVVNKNVNAPAWNEMPFSENEL 293

[Close]

BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A3S1AUT7 (Uncharacterized protein OS=Elysia chlorotica OX=188477 GN=EGW08_023369 PE=3 SV=1)

HSP 1 Score: 241.506 bits (615), Expect = 2.755e-74
Identity = 110/201 (54.73%), Postives = 151/201 (75.12%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            DPW++ GLAHFCEHM+F+G+ KY EEN Y K+LS++ G  NA+TSSE+TN+YF+I P+ L  A+D F+QFF SPLFT SAT RE+ AV+SE  +N+  D RR  QLD+ LS  +HD+ KF TGN +TL+E P   GI+VR+ LL FH +YYSSNIM +CV+ +E LD LQ  VV L   +VNK+V++P W+S P++++ ++
Sbjct:  114 DPWDIPGLAHFCEHMLFLGTRKYPEENEYNKFLSEHGGMSNAFTSSENTNYYFDISPDYLAGALDRFSQFFCSPLFTASATGREVNAVDSESSRNLQSDQRRLFQLDKSLSRPDHDFSKFGTGNKETLEEIPKSKGIDVRDELLKFHSQYYSSNIMGMCVVGRESLDELQSMVVPLVEGIVNKNVQVPSWDSSPYSENELQ 314

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BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A5N5SI74 (Insulin-degrading enzyme OS=Armadillidium nasatum OX=96803 GN=IDE PE=4 SV=1)

HSP 1 Score: 248.054 bits (632), Expect = 2.731e-73
Identity = 119/202 (58.91%), Postives = 151/202 (74.75%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDPW + GLAHFCEHM+FMG+EKY  EN Y KYLS+N G  NAYT+++HTN+YF++ PE  K AID FAQFFI+PLFTESA DRE+ AVNSEHEKN+  D  R  Q+++  SD +HDY KF TGN  TL   P +NGI+VR  LL+FH KYYS+NIM+L +L KE L+ L++  + LFS V N  V+IP+W  HP+T+  +K
Sbjct:   88 SDPWELPGLAHFCEHMLFMGTEKYPSENDYNKYLSENGGGSNAYTAADHTNYYFDVAPEDFKGAIDRFAQFFITPLFTESAVDREVNAVNSEHEKNLQNDYWRLSQVEKFTSDPDHDYSKFGTGNKDTLDIIPKQNGISVRNCLLDFHKKYYSANIMALALLGKENLNELEEIAIGLFSDVENHDVQIPYWRKHPFTEKELK 289

[Close]

BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A1B6GJ78 (Uncharacterized protein (Fragment) OS=Cuerna arida OX=1464854 GN=g.37645 PE=3 SV=1)

HSP 1 Score: 235.728 bits (600), Expect = 2.880e-73
Identity = 121/202 (59.90%), Postives = 144/202 (71.29%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP  + GLAHFCEHM+F+GSEKY  EN Y+KYLS++ G  NA TSS+HTNF+F+I P+ L  A+D FAQFF+ PLFTESATDRE+ AVNSEHEKNI  D  R  QLD+  S   H Y +F TGN  TL   P + GINVR+ LL FH K+YSSNIMSL +L KE LD L++  V+LFS V NK V  P W  HP+  D VK
Sbjct:   55 SDPKELPGLAHFCEHMLFLGSEKYPLENEYSKYLSEHGGSSNASTSSDHTNFFFDIVPDHLSGALDRFAQFFLCPLFTESATDREVNAVNSEHEKNIPSDSWRMDQLDKSTSKPGHPYSQFGTGNKLTLDTIPKELGINVRDELLKFHDKWYSSNIMSLAILGKEDLDTLEEIAVDLFSGVKNKDVTSPVWLEHPFGPDQVK 256

[Close]

BLAST of Insulin-degrading enzyme vs. TrEMBL
Match: A0A444TBR1 (Insulin-degrading enzyme OS=Armadillidium vulgare OX=13347 GN=Avbf_03640 PE=3 SV=1)

HSP 1 Score: 247.669 bits (631), Expect = 4.959e-73
Identity = 118/202 (58.42%), Postives = 152/202 (75.25%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDPW + GLAHFCEHM+FMG+EKY  EN Y KYLS+N G  NAYT+++HTN+YF++ PE  K AID FAQFFI+PLFTESA DRE+ AVNSEHEKN+  D  R  Q+++  S+ +HDY KF TGN  TL   P +NGI+VR  LL+FH KYYS+NIM+L +L KE L+ L++  + LFS V N  VEIP+W+ HP+++  +K
Sbjct:   54 SDPWELPGLAHFCEHMLFMGTEKYPSENDYNKYLSENGGGSNAYTAADHTNYYFDVAPEDFKGAIDRFAQFFITPLFTESAVDREVNAVNSEHEKNLQNDYWRLSQVEKSTSNPDHDYSKFGTGNKDTLDIIPKQNGISVRNCLLDFHKKYYSANIMALAILGKENLNELEEIAISLFSDVENHDVEIPYWSEHPFSEKELK 255

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253])

HSP 1 Score: 223.402 bits (568), Expect = 1.398e-67
Identity = 104/202 (51.49%), Postives = 145/202 (71.78%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP  + GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + +H + KF TGN  TL+  P ++GI++R+ LL FH  +YSSN+M LCVL +E LD L   VV+LF  V NK V IP +  HP+ ++H++
Sbjct:   92 SDPPKISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPDHPFSKFGTGNKLTLETRPSQDGIDIRQELLKFHSTFYSSNLMGLCVLGRESLDDLASMVVKLFGEVENKSVPIPEFPVHPFQEEHLR 293

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253])

HSP 1 Score: 223.402 bits (568), Expect = 1.647e-67
Identity = 104/202 (51.49%), Postives = 145/202 (71.78%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP  + GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + +H + KF TGN  TL+  P ++GI++R+ LL FH  +YSSN+M LCVL +E LD L   VV+LF  V NK V IP +  HP+ ++H++
Sbjct:   92 SDPPKISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPDHPFSKFGTGNKLTLETRPSQDGIDIRQELLKFHSTFYSSNLMGLCVLGRESLDDLASMVVKLFGEVENKSVPIPEFPVHPFQEEHLR 293

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253])

HSP 1 Score: 223.402 bits (568), Expect = 1.714e-67
Identity = 104/202 (51.49%), Postives = 145/202 (71.78%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP  + GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + +H + KF TGN  TL+  P ++GI++R+ LL FH  +YSSN+M LCVL +E LD L   VV+LF  V NK V IP +  HP+ ++H++
Sbjct:   92 SDPPKISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPDHPFSKFGTGNKLTLETRPSQDGIDIRQELLKFHSTFYSSNLMGLCVLGRESLDDLASMVVKLFGEVENKSVPIPEFPVHPFQEEHLR 293

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: ide (insulin degrading enzyme [Source:NCBI gene;Acc:103033253])

HSP 1 Score: 223.402 bits (568), Expect = 1.756e-67
Identity = 104/202 (51.49%), Postives = 145/202 (71.78%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP  + GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + +H + KF TGN  TL+  P ++GI++R+ LL FH  +YSSN+M LCVL +E LD L   VV+LF  V NK V IP +  HP+ ++H++
Sbjct:   79 SDPPKISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPDHPFSKFGTGNKLTLETRPSQDGIDIRQELLKFHSTFYSSNLMGLCVLGRESLDDLASMVVKLFGEVENKSVPIPEFPVHPFQEEHLR 280

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422])

HSP 1 Score: 160.614 bits (405), Expect = 2.599e-45
Identity = 86/183 (46.99%), Postives = 116/183 (63.39%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            SDP ++ GLAHF EHMVFMGSEKY  EN +  +L ++ G  NA T  E T F F+++ +  +EA+D +AQFFI PL  E A DRE++AV+SE++     D  R   L   L+  NH   KF  GN +TLK +P +N IN  E L  F  +YYS++ M+L V S+E LD L++WV E+F  V N
Sbjct:   84 SDPEDLPGLAHFLEHMVFMGSEKYPAENGFDAFLKKHGGSDNASTDCERTIFQFDVQRKYFREALDRWAQFFICPLMIEDAIDREVEAVDSEYQLARPSDSHRKEMLFGSLAKPNHPMTKFCWGNAQTLKHEPKENKINTYERLREFWKRYYSAHYMTLTVQSRETLDTLEEWVREIFIKVPN 266

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Match: ide (insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE-070410-85])

HSP 1 Score: 220.32 bits (560), Expect = 2.613e-67
Identity = 104/202 (51.49%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G++KY +EN Y+++L+++ G  NA+TS EHTNFYF++  E L  A+D F+QFF+ PLF  S  DRE+ AV+SE+EKN+  D  R  QL++   +  H + KF TGN  TL   P + G++VR+ LL FH  YYSSN+MSLCVL +EPLD + + VV+LF+ V NK+V IP +  HP+ ++H+K
Sbjct:    4 SDPDNIPGLAHFCEHMLFLGTKKYPQENEYSQFLNEHAGSSNAFTSGEHTNFYFDVSHEHLGGALDRFSQFFLCPLFDASCKDREVNAVDSENEKNLMNDSWRLFQLEKSTGNPTHPFSKFGTGNKNTLSTRPSELGLDVRDELLKFHSNYYSSNLMSLCVLGREPLDEMMEMVVKLFAQVENKNVPIPDFPEHPFQEEHLK 205

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Match: nrd1b (nardilysin b (N-arginine dibasic convertase) [Source:ZFIN;Acc:ZDB-GENE-050208-422])

HSP 1 Score: 78.9518 bits (193), Expect = 1.348e-17
Identity = 55/163 (33.74%), Postives = 85/163 (52.15%), Query Frame = 3

Query:   72 YKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTES--ATDRELQAVNSE-HEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVN 551
            Y  EN    +L ++ G  NA T  EHT +  + +   L+ A+  +AQFFISPL      + +RE+Q V+ E HE +   D          L+  +H   +   GN  +L      +G++   AL  FH ++YS+  M+L V S+E LD L++WV E+FS + N
Sbjct:    1 YPCENSLDDFLRRHGGSDNAGTDCEHTTYTLD-QNTYLQLALHRWAQFFISPLMKRERESMEREVQTVDREFHEASGVSD-------GGTLAKTSHTMGQLFWGNSASLLHSARAHGLDAHAALRQFHQRHYSACRMTLAVQSRESLDQLEEWVTEIFSKMPN 155

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BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Match: STE23 (Metalloprotease; involved in N-terminal processing of pro-a-factor to mature form; expressed in both haploids and diploids; one of two yeast homologs of human insulin-degrading enzyme (hIDE); homolog Axl1p is also involved in processing of pro-a-factor [Source:SGD;Acc:S000004381])

HSP 1 Score: 207.994 bits (528), Expect = 8.160e-63
Identity = 97/201 (48.26%), Postives = 142/201 (70.65%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            DP N+ GLAHFCEH++FMGSEK+ +EN Y+ YLS++ G  NAYT+S++TN++FE+  + L  A+D F+ FF  PLF + +TD+E+ AVNSE++KN+  DI R  QLD+ L++  H Y+KF+TGN++TL   P +NG+NVR+ LL FH  +YS+N+M LC+L +E LD L  W  +LF  V N   E+P +       +H++
Sbjct:  109 DPKNLPGLAHFCEHLLFMGSEKFPDENEYSSYLSKHGGSSNAYTASQNTNYFFEVNHQHLFGALDRFSGFFSCPLFNKDSTDKEINAVNSENKKNLQNDIWRIYQLDKSLTNTKHPYHKFSTGNIETLGTLPKENGLNVRDELLKFHKNFYSANLMKLCILGREDLDTLSDWTYDLFKDVANNGREVPLYAEPIMQPEHLQ 309

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Match: AXL1 (Haploid specific endoprotease of a-factor mating pheromone; performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells [Source:SGD;Acc:S000006326])

HSP 1 Score: 117.087 bits (292), Expect = 5.641e-31
Identity = 61/188 (32.45%), Postives = 103/188 (54.79%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVF-MGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEK------LKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREAL-LNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPV 545
            DP ++ GLAH CEHM+   GS+KY +  ++   +++NNG  NA+T+ E T FYFE+   +       +  +D+FA FF  PLF      +E+ A+ SEHE NI    +      R L++ +H + +F+TGN+ +L   P    I ++ +L   F   ++  NI +LC+   + +++L K  +  F  +
Sbjct:   59 DPKDIAGLAHLCEHMILSAGSKKYPDPGLFHTLIAKNNGSQNAFTTGEQTTFYFELPNTQNNGEFTFESILDVFASFFKEPLFNPLLISKEIYAIQSEHEGNISSTTKIFYHAARILANPDHPFSRFSTGNIHSLSSIPQLKKIKLKSSLNTYFENNFFGENI-TLCIRGPQSVNILTKLALSKFGDI 245

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Match: MAS1 (Beta subunit of the mitochondrial processing protease (MPP); essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Source:SGD;Acc:S000004153])

HSP 1 Score: 52.7582 bits (125), Expect = 6.695e-9
Identity = 29/89 (32.58%), Postives = 47/89 (52.81%), Query Frame = 3

Query:   24 GLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGD-FNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEK 287
            G AHF EH+ F G++   ++ I  +   +N G   NAYTS E+T +Y +   E + +A+DI +      +   SA +RE   +  E E+
Sbjct:   67 GTAHFLEHLAFKGTQNRSQQGIELEI--ENIGSHLNAYTSRENTVYYAKSLQEDIPKAVDILSDILTKSVLDNSAIERERDVIIRESEE 153

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO37735 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEX7])

HSP 1 Score: 216.853 bits (551), Expect = 1.041e-65
Identity = 105/202 (51.98%), Postives = 140/202 (69.31%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            +DP  + GLAHFCEHM+F+G+EKY  EN Y ++L++N G  NA+TS EHTN++F++K E L  A+D FAQFF+ PLF   A DRE+ AV+SE+ KN   D+ R  QLD+   D +H Y KF TGN  TL   P + GI+ RE LL FH  YYS+NIMSL V+ +E LD + + VV+LFSPV NK+V IP +  HP+  + V+
Sbjct:   55 TDPKELPGLAHFCEHMLFLGTEKYPGENAYTQFLTENGGSSNAFTSGEHTNYFFDVKYESLSNALDRFAQFFLCPLFNADAKDREVNAVDSENSKNRLNDMWRLNQLDKSTVDPSHPYNKFCTGNKLTLDTRPKEKGIDTREELLKFHSLYYSANIMSLSVIGRESLDEMTEMVVKLFSPVQNKNVTIPTFPEHPYGAEQVQ 256

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO31509 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SXQ6])

HSP 1 Score: 165.622 bits (418), Expect = 2.076e-47
Identity = 84/186 (45.16%), Postives = 120/186 (64.52%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHV 560
            SDP ++ GLAHF EHMVFMGSEKY +EN +  ++ ++ G+ NA+T  E T F F+++ +  +EA+D FAQFFI PL    + +RE++AV SE+  +   D  + +QL + L+   H Y KF  G+  TL+  P++ GI+V   L  F  K YSS  M+L V SKEPLD L+ WV +LFS V N ++
Sbjct:   41 SDPDDIPGLAHFLEHMVFMGSEKYPDENSFDAFIKKHGGNSNAFTDCERTVFVFDVRRKHFREALDRFAQFFICPLLKSGSIEREIKAVESEYRMSYQNDQVKKMQLLQSLARDGHPYRKFLWGSESTLQTTPEEKGIDVCGQLKKFMTKMYSSQYMTLAVCSKEPLDTLELWVEKLFSTVPNNYL 226

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO39505 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9Y6])

HSP 1 Score: 50.447 bits (119), Expect = 1.323e-7
Identity = 49/182 (26.92%), Postives = 86/182 (47.25%), Query Frame = 3

Query:   24 GLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGD-FNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINV-REALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVE 563
            G+AHF EHM F G++   + ++  +   +N G   NAYTS E T +Y ++  + + +A+DI A    +    E+  +RE   +  E ++   VD     QL+  + D  H      T   +T+   P +N  ++ ++ L ++  K+YS+  M L        D L K     FS + + + E
Sbjct:   95 GVAHFLEHMAFKGTKNRSQMDLELEV--ENMGAHLNAYTSREQTVYYAKVFSKDIPKAVDILADIIQNSTLGEAEIERERGVILREMQE---VDT----QLEEVVFDHLHATAYQGTALGRTIL-GPSRNVKSITQQDLKDYINKHYSAPRMVLAAAGGVNHDDLVKLAENHFSGLRSTYEE 266

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Match: EDO25381 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8DWM9])

HSP 1 Score: 48.1358 bits (113), Expect = 6.333e-7
Identity = 38/190 (20.00%), Postives = 89/190 (46.84%), Query Frame = 3

Query:   24 GLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDR--NHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHP 587
            G+AH  EHM+F GS K      +++ ++   G  NA+TS ++T +Y +I   +L++ + + +  F +  + +S   +E++ +  E       D  R + +++ ++       Y++   G +  L  D    G +VR    +FHG++Y     ++ +     +  ++ W  + +  +  + + +    + P
Sbjct:   33 GVAHALEHMMFKGSRKVAPGE-FSRRVAALGGQENAFTSRDYTGYYQQIPSSRLEDVMKLESDRFANNHWPDSEFKKEIEVIKEERRMR-TEDQPRAVLMEQLMAATFVASPYHRPVIGWMSDL--DALTPG-DVR----DFHGRWYVPGNATIVIAGDVDVAKVRAWAEKYYGSIPARALPVRKPRTEP 213

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101158223])

HSP 1 Score: 227.254 bits (578), Expect = 4.636e-69
Identity = 107/202 (52.97%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI+VR+ LL FH  YYS+N+M LCVL +E LD L   VV+LF  V NK+V IP +  HP+ ++H++
Sbjct:   94 SDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPCEEGIDVRQELLKFHSTYYSANLMGLCVLGRESLDELTSMVVKLFGEVENKNVPIPEFPDHPFQEEHLR 295

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101158223])

HSP 1 Score: 227.639 bits (579), Expect = 5.791e-69
Identity = 107/202 (52.97%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI+VR+ LL FH  YYS+N+M LCVL +E LD L   VV+LF  V NK+V IP +  HP+ ++H++
Sbjct:   94 SDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPCEEGIDVRQELLKFHSTYYSANLMGLCVLGRESLDELTSMVVKLFGEVENKNVPIPEFPDHPFQEEHLR 295

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101158223])

HSP 1 Score: 227.254 bits (578), Expect = 6.531e-69
Identity = 107/202 (52.97%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP N+ GLAHFCEHM+F+G+EKY +EN Y+++LS++ G  NA+TS EHTN+YF++  E L+ A+D FAQFF+ PLF ES  DRE+ AV+SEHEKN+  D  R  QL++   + NH + KF TGN  TL+  P + GI+VR+ LL FH  YYS+N+M LCVL +E LD L   VV+LF  V NK+V IP +  HP+ ++H++
Sbjct:   94 SDPENISGLAHFCEHMLFLGTEKYPKENEYSQFLSEHAGSSNAFTSGEHTNYYFDVSHEHLQGALDRFAQFFLCPLFDESCKDREVNAVDSEHEKNLMNDAWRLFQLEKATGNPNHPFSKFGTGNKLTLETRPCEEGIDVRQELLKFHSTYYSANLMGLCVLGRESLDELTSMVVKLFGEVENKNVPIPEFPDHPFQEEHLR 295

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559])

HSP 1 Score: 223.787 bits (569), Expect = 9.589e-68
Identity = 106/202 (52.48%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP +V GLAHFCEHM+F+G+EKY +EN Y+++LSQ+ G  NA+TSS+HTN++F++  E L+ A+D FA FF+ PLF ES  DREL AV+SE+ KN+  D RR  QL++   D NH + KF TGN  TL+  P + GI+VR+ LL FH  YYS+N+M LCVL +E LD L   VV+LF  V NK+V +P +  HP+ ++H++
Sbjct:   57 SDPDSVPGLAHFCEHMLFLGTEKYPKENEYSQFLSQHGGSDNAFTSSDHTNYFFDVSHEHLQGALDRFAPFFLCPLFDESCKDRELNAVDSEYRKNLMNDDRRLFQLEKATCDPNHPFRKFRTGNKLTLETRPCEEGIDVRQELLKFHSTYYSANLMGLCVLGRESLDELTSMVVKLFGEVENKNVPVPEFPEHPFQEEHLR 258

[Close]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Match: ide (insulin-degrading enzyme [Source:NCBI gene;Acc:101157559])

HSP 1 Score: 223.787 bits (569), Expect = 1.161e-67
Identity = 106/202 (52.48%), Postives = 146/202 (72.28%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDP +V GLAHFCEHM+F+G+EKY +EN Y+++LSQ+ G  NA+TSS+HTN++F++  E L+ A+D FA FF+ PLF ES  DREL AV+SE+ KN+  D RR  QL++   D NH + KF TGN  TL+  P + GI+VR+ LL FH  YYS+N+M LCVL +E LD L   VV+LF  V NK+V +P +  HP+ ++H++
Sbjct:   57 SDPDSVPGLAHFCEHMLFLGTEKYPKENEYSQFLSQHGGSDNAFTSSDHTNYFFDVSHEHLQGALDRFAPFFLCPLFDESCKDRELNAVDSEYRKNLMNDDRRLFQLEKATCDPNHPFRKFRTGNKLTLETRPCEEGIDVRQELLKFHSTYYSANLMGLCVLGRESLDELTSMVVKLFGEVENKNVPVPEFPEHPFQEEHLR 258

[Close]

BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000016400.1 (SMESG000016400.1)

HSP 1 Score: 429.869 bits (1104), Expect = 9.935e-146
Identity = 202/202 (100.00%), Postives = 202/202 (100.00%), Query Frame = 3

Query:    3 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 608
            SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK
Sbjct:   61 SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDHVK 262

[Close]

BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000041455.1 (SMESG000041455.1)

HSP 1 Score: 138.658 bits (348), Expect = 1.159e-37
Identity = 75/180 (41.67%), Postives = 109/180 (60.56%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPV 545
            DP  + GLAH+ EHMVFMGSEKY  EN +   +SQ+ G  NA+T +E T FYF+   +  +  +D FA FF+SPL  + + +RE+ AVNSE E     D +R   L +  S  +  Y  F  GN K+LK+DP    I++ + L +F  + YSS+ M+L + S++ LD L+K V  +FS +
Sbjct:   70 DPMELQGLAHYLEHMVFMGSEKYPNENDFDSCVSQHGGSSNAWTDNERTLFYFDSHFKHFESILDKFANFFVSPLLLKDSMNREVTAVNSEFEMGYSNDTQRIEYLLQLTSKSDSPYRIFQCGNTKSLKDDPTAKNIDIYKYLQDFRAQMYSSHWMTLAIQSRDTLDNLEKMVRSIFSCI 249

[Close]

BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Match: SMESG000041455.1 (SMESG000041455.1)

HSP 1 Score: 138.658 bits (348), Expect = 1.160e-37
Identity = 75/180 (41.67%), Postives = 109/180 (60.56%), Query Frame = 3

Query:    6 DPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHTNFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVDIRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGKYYSSNIMSLCVLSKEPLDVLQKWVVELFSPV 545
            DP  + GLAH+ EHMVFMGSEKY  EN +   +SQ+ G  NA+T +E T FYF+   +  +  +D FA FF+SPL  + + +RE+ AVNSE E     D +R   L +  S  +  Y  F  GN K+LK+DP    I++ + L +F  + YSS+ M+L + S++ LD L+K V  +FS +
Sbjct:   74 DPMELQGLAHYLEHMVFMGSEKYPNENDFDSCVSQHGGSSNAWTDNERTLFYFDSHFKHFESILDKFANFFVSPLLLKDSMNREVTAVNSEFEMGYSNDTQRIEYLLQLTSKSDSPYRIFQCGNTKSLKDDPTAKNIDIYKYLQDFRAQMYSSHWMTLAIQSRDTLDNLEKMVRSIFSCI 253

The following BLAST results are available for this feature:

BLAST of Insulin-degrading enzyme vs. Ensembl Human
BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
BLAST of Insulin-degrading enzyme vs. Ensembl Fly
BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
BLAST of Insulin-degrading enzyme vs. TrEMBL
BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
BLAST of Insulin-degrading enzyme vs. Planmine SMEST

BLAST of Insulin-degrading enzyme vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IDE	1.198e-67	51.98	insulin degrading enzyme [Source:HGNC Symbol;Acc:H...	[more]
IDE	1.198e-67	51.98	insulin degrading enzyme [Source:HGNC Symbol;Acc:H...	[more]
IDE	2.889e-63	52.87	insulin degrading enzyme [Source:HGNC Symbol;Acc:H...	[more]
NRDC	3.480e-44	44.79	nardilysin convertase [Source:HGNC Symbol;Acc:HGNC...	[more]
NRDC	3.516e-44	44.79	nardilysin convertase [Source:HGNC Symbol;Acc:HGNC...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
F44E7.4	6.089e-68	53.23	pep chromosome:WBcel235:V:5773295:5776951:-1 gene:...	[more]
F44E7.4	6.794e-68	53.23	pep chromosome:WBcel235:V:5772831:5776953:-1 gene:...	[more]
F44E7.4	6.794e-68	53.23	pep chromosome:WBcel235:V:5772831:5776655:-1 gene:...	[more]
F44E7.4	8.124e-68	53.23	pep chromosome:WBcel235:V:5772831:5776951:-1 gene:...	[more]
F44E7.4	8.124e-68	53.23	pep chromosome:WBcel235:V:5772832:5777034:-1 gene:...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ide	1.100e-66	53.00	gene:FBgn0001247 transcript:FBtr0273273	[more]
Nrd1	1.829e-32	36.27	gene:FBgn0030344 transcript:FBtr0073601	[more]
CG10588	6.646e-26	36.59	gene:FBgn0037037 transcript:FBtr0078284	[more]
CG10588	6.646e-26	36.59	gene:FBgn0037037 transcript:FBtr0346528	[more]
UQCR-C1	8.039e-7	31.00	gene:FBgn0038271 transcript:FBtr0083000	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ide	2.963e-69	52.48	insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE...	[more]
nrd1b	1.779e-45	45.90	nardilysin b (N-arginine dibasic convertase) [Sour...	[more]
nrd1a	3.000e-45	46.99	nardilysin a (N-arginine dibasic convertase) [Sour...	[more]
nrd1a	3.000e-45	46.99	nardilysin a (N-arginine dibasic convertase) [Sour...	[more]
nrd1b	1.143e-44	45.90	nardilysin b (N-arginine dibasic convertase) [Sour...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
IDE	2.195e-68	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:100...	[more]
IDE	2.578e-68	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:100...	[more]
IDE	2.740e-68	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:100...	[more]
IDE	2.844e-68	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:100...	[more]
IDE	3.045e-68	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:100...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ide	3.406e-67	51.49	insulin degrading enzyme [Source:MGI Symbol;Acc:MG...	[more]
Ide	3.406e-67	51.49	insulin degrading enzyme [Source:MGI Symbol;Acc:MG...	[more]
Nrd1	3.868e-44	44.27	nardilysin, N-arginine dibasic convertase, NRD con...	[more]
Nrd1	4.312e-44	44.27	nardilysin, N-arginine dibasic convertase, NRD con...	[more]
Nrd1	5.666e-39	42.94	nardilysin, N-arginine dibasic convertase, NRD con...	[more]

BLAST of Insulin-degrading enzyme vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q24K02\|IDE_BOVIN	4.953e-67	51.98	Insulin-degrading enzyme OS=Bos taurus OX=9913 GN=...	[more]
sp\|P14735\|IDE_HUMAN	5.755e-67	51.98	Insulin-degrading enzyme OS=Homo sapiens OX=9606 G...	[more]
sp\|P35559\|IDE_RAT	1.611e-66	51.98	Insulin-degrading enzyme OS=Rattus norvegicus OX=1...	[more]
sp\|P22817\|IDE_DROME	1.103e-65	53.00	Insulin-degrading enzyme OS=Drosophila melanogaste...	[more]
sp\|Q9JHR7\|IDE_MOUSE	1.876e-65	50.99	Insulin-degrading enzyme OS=Mus musculus OX=10090 ...	[more]

BLAST of Insulin-degrading enzyme vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2R7VZW3	8.433e-75	58.21	Uncharacterized protein (Fragment) OS=Oncopeltus f...	[more]
A0A3S1AUT7	2.755e-74	54.73	Uncharacterized protein OS=Elysia chlorotica OX=18...	[more]
A0A5N5SI74	2.731e-73	58.91	Insulin-degrading enzyme OS=Armadillidium nasatum ...	[more]
A0A1B6GJ78	2.880e-73	59.90	Uncharacterized protein (Fragment) OS=Cuerna arida...	[more]
A0A444TBR1	4.959e-73	58.42	Insulin-degrading enzyme OS=Armadillidium vulgare ...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ide	1.398e-67	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:103...	[more]
ide	1.647e-67	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:103...	[more]
ide	1.714e-67	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:103...	[more]
ide	1.756e-67	51.49	insulin degrading enzyme [Source:NCBI gene;Acc:103...	[more]
nrd1b	2.599e-45	46.99	nardilysin b (N-arginine dibasic convertase) [Sour...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ide	2.613e-67	51.49	insulin-degrading enzyme [Source:ZFIN;Acc:ZDB-GENE...	[more]
nrd1b	1.348e-17	33.74	nardilysin b (N-arginine dibasic convertase) [Sour...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
STE23	8.160e-63	48.26	Metalloprotease; involved in N-terminal processing...	[more]
AXL1	5.641e-31	32.45	Haploid specific endoprotease of a-factor mating p...	[more]
MAS1	6.695e-9	32.58	Beta subunit of the mitochondrial processing prote...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4


Match Name	E-value	Identity	Description
EDO37735	1.041e-65	51.98	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO31509	2.076e-47	45.16	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO39505	1.323e-7	26.92	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO25381	6.333e-7	20.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A8...	[more]

BLAST of Insulin-degrading enzyme vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ide	4.636e-69	52.97	insulin-degrading enzyme [Source:NCBI gene;Acc:101...	[more]
ide	5.791e-69	52.97	insulin-degrading enzyme [Source:NCBI gene;Acc:101...	[more]
ide	6.531e-69	52.97	insulin-degrading enzyme [Source:NCBI gene;Acc:101...	[more]
ide	9.589e-68	52.48	insulin-degrading enzyme [Source:NCBI gene;Acc:101...	[more]
ide	1.161e-67	52.48	insulin-degrading enzyme [Source:NCBI gene;Acc:101...	[more]

BLAST of Insulin-degrading enzyme vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3


Match Name	E-value	Identity	Description
SMESG000016400.1	9.935e-146	100.00	SMESG000016400.1	[more]
SMESG000041455.1	1.159e-37	41.67	SMESG000041455.1	[more]
SMESG000041455.1	1.160e-37	41.67	SMESG000041455.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30020179 ID=SMED30020179|Name=Insulin-degrading enzyme|organism=Schmidtea mediterranea sexual|type=transcript|length=609bp
TTTCTGACCCATGGAATGTAATGGGATTAGCCCATTTTTGTGAACATATG
GTATTTATGGGTTCTGAAAAATACAAAGAAGAAAATATTTATGCTAAATA
TCTATCGCAAAATAATGGGGATTTTAATGCTTATACATCATCCGAACACA
CTAATTTCTATTTTGAAATCAAGCCAGAAAAGCTTAAAGAAGCCATCGAC
ATATTCGCTCAGTTTTTTATATCACCTTTATTCACTGAATCTGCTACAGA
TCGTGAATTACAAGCGGTCAATTCGGAACACGAGAAAAATATTTGCGTGG
ATATTCGTCGAAATTTGCAATTAGATCGTCATTTATCGGATAGAAATCAT
GACTATTACAAGTTTGCAACTGGCAATCTTAAAACTTTGAAAGAAGATCC
CGATAAAAATGGCATAAATGTTCGTGAAGCTCTTCTAAATTTCCATGGAA
AATATTATTCTTCAAACATTATGAGCTTGTGTGTTTTGAGTAAAGAACCT
CTTGATGTGCTGCAAAAATGGGTAGTGGAGTTATTTAGTCCTGTGGTAAA
TAAGCACGTTGAGATCCCTCATTGGAACAGCCATCCTTGGACTCAAGACC
ACGTGAAGC

protein sequence of SMED30020179-orf-1

>SMED30020179-orf-1 ID=SMED30020179-orf-1|Name=SMED30020179-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=202bp
SDPWNVMGLAHFCEHMVFMGSEKYKEENIYAKYLSQNNGDFNAYTSSEHT
NFYFEIKPEKLKEAIDIFAQFFISPLFTESATDRELQAVNSEHEKNICVD
IRRNLQLDRHLSDRNHDYYKFATGNLKTLKEDPDKNGINVREALLNFHGK
YYSSNIMSLCVLSKEPLDVLQKWVVELFSPVVNKHVEIPHWNSHPWTQDH
VK

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR011765	Pept_M16_N
IPR011237	Pept_M16_dom
IPR007863	Peptidase_M16_C
IPR011249	Metalloenz_LuxS/M16

Vocabulary: **molecular function**
Term	Definition
GO:0046872	metal ion binding
GO:0003824	catalytic activity
GO:0004222	metalloendopeptidase activity

Vocabulary: **biological process**
Term	Definition
GO:0006508	proteolysis

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR007863	Peptidase M16, C-terminal	PFAM	PF05193	Peptidase_M16_C	coord: 141..196 e-value: 2.8E-4 score: 21.0
IPR011765	Peptidase M16, N-terminal	PFAM	PF00675	Peptidase_M16	coord: 2..112 e-value: 3.4E-33 score: 114.7
None	No IPR available	GENE3D	G3DSA:3.30.830.10		coord: 1..187 e-value: 4.7E-70 score: 237.8
None	No IPR available	PANTHER	PTHR43690:SF2	INSULIN-DEGRADING ENZYME	coord: 1..196
None	No IPR available	PANTHER	PTHR43690	FAMILY NOT NAMED	coord: 1..196
IPR011249	Metalloenzyme, LuxS/M16 peptidase-like	SUPERFAMILY	SSF63411	LuxS/MPP-like metallohydrolase	coord: 1..188