Ubiquitinyl hydrolase 1

Overview
NameUbiquitinyl hydrolase 1
Smed IDSMED30020178
Length (bp)1815
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Ubiquitinyl hydrolase 1 (SMED30020178) t-SNE clustered cells

Violin plots show distribution of expression levels for Ubiquitinyl hydrolase 1 (SMED30020178) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Ubiquitinyl hydrolase 1 (SMED30020178) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Ubiquitinyl hydrolase 1 (SMED30020178) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30020178

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 5

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30020178SMESG000057792.1 SMESG000057788.1 dd_Smed_v4_2744_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30020178SMESG000057792.1 SMESG000057788.1 dd_Smed_v4_2744_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30020178SMESG000057792.1 SMESG000057788.1 dd_Smed_v4_2744_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
reproductive organSMED30020178 Contig26065newmark_estsPMID:28434803
Rouhana et al., 2017
whole organism adult hermaphrodite RNA-sequencing evidence
epidermisSMED30020178SMESG000057792.1 SMESG000057788.1 dd_Smed_v4_2744_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Xenopus
Match: usp33 (ubiquitin specific peptidase 33 [Source:NCBI gene;Acc:548982])

HSP 1 Score: 52.373 bits (124), Expect = 2.208e-6
Identity = 47/150 (31.33%), Postives = 73/150 (48.67%), Query Frame = 3
Query:  888 PGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPK--YHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNN----WYLVSDEQV-ELMEFS-GNICPYILIYEK 1313
            P VTL+  +   F+   + G+     +   ++  P++L +H++  +     E M   K   H+ +  E     D+   L KD+  +I VTY L +V+ H GT S GHY+AY   RNN    WY   D+ V E+ E +  N   Y+L Y K
Sbjct:  511 PTVTLQDCLAAFFARDELKGELRNGVKFCKVQKFPEILCIHLKRFR----HELMFSTKIGTHVSFPLE---GLDLQPFLAKDSPSQI-VTYDLLSVICHHGTASSGHYIAY--CRNNLNNLWYEFDDQSVTEVSEATVQNAEAYVLFYRK 650          
BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Match: M7WCD8 (Ubiquitin carboxyl-terminal hydrolase, putative OS=Entamoeba histolytica HM-3:IMSS OX=885315 GN=KM1_014680 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.175e-7
Identity = 85/332 (25.60%), Postives = 141/332 (42.47%), Query Frame = 3
Query:  450 GFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHET--YKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFK--------AQNIDDI---EMPLKLKMVYR--------------FKG------LDIPDRTQYHLGLSLG----LSGPYETKPGV--TLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGT-ISGGHYVAYRKWRNNWYLVSDEQVELMEFSG--NICPYILIYEKIG 1319
            G KN   TC+ N++ Q   S    +   + ++ T   K + ++K  +++ +  N      E +    +  E +++L   +  +Q DA E +T LI  +  E K        AQ  DD    E+  K K V                F+G      + I +  + H    L     LS P ++K     ++   I   FS   ID   N   Q  F+++AP VL+L +    +D VK  ++K   HI Y   + +        NK NV      YRL ++++H G  I  GHYV+Y +    WY  +DE ++L++     +   Y+LIY  + 
Sbjct:   20 GIKNFRSTCFANSVFQVLCSLPPFVEYLKKVNPTDDMKYTKAIKDMFNLFLQCNKVGIQKEIIHPPQSMKEIIMKLQTESGQHQMDATEFYTTLINCLHTECKNKISEGEEAQQDDDEGWEEVGKKFKKVQLRSEKTDGTSVISDYFRGSMRSLTITIDEMKKKHNQAVLQEFYVLSLPIQSKQNCVSSVSQAINLAFSKRKID---NTHFQQLFIEEAPKVLVLQLNRFIYDRVKLDVVKLVDHINYTESLQL------KTNKGNV-----NYRLISIIEHRGNQIRRGHYVSYVRRGEKWYFCNDENIQLIDQKDIYDKMAYVLIYSSLN 337          
BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Match: N9UVY3 (Ubiquitin carboxyl-terminal hydrolase, putative OS=Entamoeba histolytica HM-1:IMSS-A OX=885318 GN=EHI7A_003850 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.175e-7
Identity = 85/332 (25.60%), Postives = 141/332 (42.47%), Query Frame = 3
Query:  450 GFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHET--YKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFK--------AQNIDDI---EMPLKLKMVYR--------------FKG------LDIPDRTQYHLGLSLG----LSGPYETKPGV--TLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGT-ISGGHYVAYRKWRNNWYLVSDEQVELMEFSG--NICPYILIYEKIG 1319
            G KN   TC+ N++ Q   S    +   + ++ T   K + ++K  +++ +  N      E +    +  E +++L   +  +Q DA E +T LI  +  E K        AQ  DD    E+  K K V                F+G      + I +  + H    L     LS P ++K     ++   I   FS   ID   N   Q  F+++AP VL+L +    +D VK  ++K   HI Y   + +        NK NV      YRL ++++H G  I  GHYV+Y +    WY  +DE ++L++     +   Y+LIY  + 
Sbjct:   20 GIKNFRSTCFANSVFQVLCSLPPFVEYLKKVNPTDDMKYTKAIKDMFNLFLQCNKVGIQKEIIHPPQSMKEIIMKLQTESGQHQMDATEFYTTLINCLHTECKNKISEGEEAQQDDDEGWEEVGKKFKKVQLRSEKTDGTSVISDYFRGSMRSLTITIDEMKKKHNQAVLQEFYVLSLPIQSKQNCVSSVSQAINLAFSKRKID---NTHFQQLFIEEAPKVLVLQLNRFIYDRVKLDVVKLVDHINYTESLQL------KTNKGNV-----NYRLISIIEHRGNQIRRGHYVSYVRRGEKWYFCNDENIQLIDQKDIYDKMAYVLIYSSLN 337          
BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Match: M2RXF3 (Ubiquitin carboxylterminal hydrolase, putative OS=Entamoeba histolytica KU27 OX=885311 GN=EHI5A_014020 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.175e-7
Identity = 85/332 (25.60%), Postives = 141/332 (42.47%), Query Frame = 3
Query:  450 GFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHET--YKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFK--------AQNIDDI---EMPLKLKMVYR--------------FKG------LDIPDRTQYHLGLSLG----LSGPYETKPGV--TLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGT-ISGGHYVAYRKWRNNWYLVSDEQVELMEFSG--NICPYILIYEKIG 1319
            G KN   TC+ N++ Q   S    +   + ++ T   K + ++K  +++ +  N      E +    +  E +++L   +  +Q DA E +T LI  +  E K        AQ  DD    E+  K K V                F+G      + I +  + H    L     LS P ++K     ++   I   FS   ID   N   Q  F+++AP VL+L +    +D VK  ++K   HI Y   + +        NK NV      YRL ++++H G  I  GHYV+Y +    WY  +DE ++L++     +   Y+LIY  + 
Sbjct:   20 GIKNFRSTCFANSVFQVLCSLPPFVEYLKKVNPTDDMKYTKAIKDMFNLFLQCNKVGIQKEIIHPPQSMKEIIMKLQTESGQHQMDATEFYTTLINCLHTECKNKISEGEEAQQDDDEGWEEVGKKFKKVQLRSEKTDGTSVISDYFRGSMRSLTITIDEMKKKHNQAVLQEFYVLSLPIQSKQNCVSSVSQAINLAFSKRKID---NTHFQQLFIEEAPKVLVLQLNRFIYDRVKLDVVKLVDHINYTESLQL------KTNKGNV-----NYRLISIIEHRGNQIRRGHYVSYVRRGEKWYFCNDENIQLIDQKDIYDKMAYVLIYSSLN 337          
BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Match: M3UQH1 (Ubiquitin carboxyl-terminal hydrolase domain containing protein OS=Entamoeba histolytica HM-1:IMSS-B OX=885319 GN=EHI8A_002150 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.175e-7
Identity = 85/332 (25.60%), Postives = 141/332 (42.47%), Query Frame = 3
Query:  450 GFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHET--YKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFK--------AQNIDDI---EMPLKLKMVYR--------------FKG------LDIPDRTQYHLGLSLG----LSGPYETKPGV--TLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGT-ISGGHYVAYRKWRNNWYLVSDEQVELMEFSG--NICPYILIYEKIG 1319
            G KN   TC+ N++ Q   S    +   + ++ T   K + ++K  +++ +  N      E +    +  E +++L   +  +Q DA E +T LI  +  E K        AQ  DD    E+  K K V                F+G      + I +  + H    L     LS P ++K     ++   I   FS   ID   N   Q  F+++AP VL+L +    +D VK  ++K   HI Y   + +        NK NV      YRL ++++H G  I  GHYV+Y +    WY  +DE ++L++     +   Y+LIY  + 
Sbjct:   20 GIKNFRSTCFANSVFQVLCSLPPFVEYLKKVNPTDDMKYTKAIKDMFNLFLQCNKVGIQKEIIHPPQSMKEIIMKLQTESGQHQMDATEFYTTLINCLHTECKNKISEGEEAQQDDDEGWEEVGKKFKKVQLRSEKTDGTSVISDYFRGSMRSLTITIDEMKKKHNQAVLQEFYVLSLPIQSKQNCVSSVSQAINLAFSKRKID---NTHFQQLFIEEAPKVLVLQLNRFIYDRVKLDVVKLVDHINYTESLQL------KTNKGNV-----NYRLISIIEHRGNQIRRGHYVSYVRRGEKWYFCNDENIQLIDQKDIYDKMAYVLIYSSLN 337          
BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Match: C4LXH7 (Ubiquitin carboxyl-terminal hydrolase, putative OS=Entamoeba histolytica OX=5759 GN=EHI_131090 PE=3 SV=1)

HSP 1 Score: 64.6994 bits (156), Expect = 2.175e-7
Identity = 85/332 (25.60%), Postives = 141/332 (42.47%), Query Frame = 3
Query:  450 GFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHET--YKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFK--------AQNIDDI---EMPLKLKMVYR--------------FKG------LDIPDRTQYHLGLSLG----LSGPYETKPGV--TLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGT-ISGGHYVAYRKWRNNWYLVSDEQVELMEFSG--NICPYILIYEKIG 1319
            G KN   TC+ N++ Q   S    +   + ++ T   K + ++K  +++ +  N      E +    +  E +++L   +  +Q DA E +T LI  +  E K        AQ  DD    E+  K K V                F+G      + I +  + H    L     LS P ++K     ++   I   FS   ID   N   Q  F+++AP VL+L +    +D VK  ++K   HI Y   + +        NK NV      YRL ++++H G  I  GHYV+Y +    WY  +DE ++L++     +   Y+LIY  + 
Sbjct:   20 GIKNFRSTCFANSVFQVLCSLPPFVEYLKKVNPTDDMKYTKAIKDMFNLFLQCNKVGIQKEIIHPPQSMKEIIMKLQTESGQHQMDATEFYTTLINCLHTECKNKISEGEEAQQDDDEGWEEVGKKFKKVQLRSEKTDGTSVISDYFRGSMRSLTITIDEMKKKHNQAVLQEFYVLSLPIQSKQNCVSSVSQAINLAFSKRKID---NTHFQQLFIEEAPKVLVLQLNRFIYDRVKLDVVKLVDHINYTESLQL------KTNKGNV-----NYRLISIIEHRGNQIRRGHYVSYVRRGEKWYFCNDENIQLIDQKDIYDKMAYVLIYSSLN 337          
BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Yeast
Match: UBP1 (Ubiquitin-specific protease; removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains [Source:SGD;Acc:S000002280])

HSP 1 Score: 48.1358 bits (113), Expect = 3.512e-6
Identity = 20/43 (46.51%), Postives = 29/43 (67.44%), Query Frame = 3
Query: 1131 VKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQV 1259
            V    +TY L +V+ H GT + GHY+A+RK+R  W+ +SDE V
Sbjct:  674 VPATPLTYSLRSVIVHYGTHNYGHYIAFRKYRGCWWRISDETV 716          
BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Match: SMESG000057792.1 (SMESG000057792.1)

HSP 1 Score: 646.351 bits (1666), Expect = 0.000e+0
Identity = 352/358 (98.32%), Postives = 354/358 (98.88%), Query Frame = 3
Query:  255 MVSIDFHAVDYWLYVSXXXXXXXXXXXXXXXXXXXXYHYRQKIRKLLICEKIVPFSTGYIYDKPSGFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHETYKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGLSLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 1328
            MVSID HAVDYWLYVSLILIMILVIIFLVGIICFCIYHYRQKIRKLLICEKIVPFSTGYIYDKPSGFKNLAETCYMNAIIQAAASSQILISQFQHLHETYKESMSLKCFYDVLIGVNTPDDSY RLCKNTNQLETLIRLVNWTKTNQQDAFELFT LIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGLSLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLK APDVLLLHIQANKWDSVKEKMIKPKYHIVY++EMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE
Sbjct:    1 MVSIDLHAVDYWLYVSLILIMILVIIFLVGIICFCIYHYRQKIRKLLICEKIVPFSTGYIYDKPSGFKNLAETCYMNAIIQAAASSQILISQFQHLHETYKESMSLKCFYDVLIGVNTPDDSYVRLCKNTNQLETLIRLVNWTKTNQQDAFELFTALIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGLSLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKGAPDVLLLHIQANKWDSVKEKMIKPKYHIVYDQEMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 358          
BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Match: SMESG000057788.1 (SMESG000057788.1)

HSP 1 Score: 311.227 bits (796), Expect = 1.321e-103
Identity = 151/161 (93.79%), Postives = 154/161 (95.65%), Query Frame = 3
Query:  849 GLSLG-LSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 1328
            G+SL  L+     KPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNK+NVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE
Sbjct:   13 GVSLEILTEMISAKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKENVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 173          
BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Match: SMESG000057788.1 (SMESG000057788.1)

HSP 1 Score: 318.546 bits (815), Expect = 1.477e-102
Identity = 150/158 (94.94%), Postives = 154/158 (97.47%), Query Frame = 3
Query:  855 SLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 1328
            ++G+S    TKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNK+NVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE
Sbjct:  287 TIGVSPTKATKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKENVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKIGSAE 444          
BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Match: SMESG000057810.1 (SMESG000057810.1)

HSP 1 Score: 247.669 bits (631), Expect = 5.850e-77
Identity = 133/303 (43.89%), Postives = 198/303 (65.35%), Query Frame = 3
Query:  399 CEKIVPFSTGYIYDKPSGFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHETYKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGLSLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIY 1307
            CE++  +   Y   +PSG +N+ E CYMN++IQ+ ASS  +I+QF+ L +   E   +    D+L  VN  + + E   +N+++L     L+NW K  QQD F+    +IK I  E K +++   + PLK+K++Y+  G++IP++TQ HLGLSLGL G Y   PGV  + L+ E+F+ TLID D  KTSQLF   + PDVL++HIQANKWDS   +M KPKYHI+YE+   I F +++  N+  +  I+ TY L AV+ HMG IS GHY+ YRK+++ W+L +D Q+E + F+ ++CPYIL+Y
Sbjct:   20 CEEMPIYKITYNKCRPSGLRNMNENCYMNSLIQSLASSDKIINQFKELQKIDGEHKLVDLLIDILTSVNNSESTPE---ENSSKLMKFSELMNWGKDRQQDTFDFLCAIIKNIQLEIKDKSM--FQCPLKIKVMYKITGMEIPNKTQDHLGLSLGLCGNYSVSPGVLFDDLVKEYFTATLIDDDETKTSQLFIYGNVPDVLIIHIQANKWDSNLGEMYKPKYHIIYEKYPNISFKVMSTSNE--MMEINYTYDLHAVIYHMGEISSGHYITYRKFQDKWFLANDTQIEEVLFNCDVCPYILVY 315          
BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Match: SMESG000057791.1 (SMESG000057791.1)

HSP 1 Score: 246.899 bits (629), Expect = 9.871e-77
Identity = 139/314 (44.27%), Postives = 192/314 (61.15%), Query Frame = 3
Query:  375 QKIRKLLICEKIVPFSTGYIYDKPSGFKNLAETCYMNXXXXXXXXXXXXXXXXXHLHETYKESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDAFELFTVLIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGLSLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLLLHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTYRLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILIYEKI 1316
            + I K   C  +  F+      +P    N +  CYM ++IQA A+S ILI+QF+ +++ Y    SL    D+L GV       +   +NT  L  LI  + W K +QQDAFE+ T + K ISD  K        +P+K+K+++ FKG+D+ ++ Q +LGLSLGL G Y  +PGV LE+LI +HF P+LIDG+PNKTS +   + AP++LLLHIQANKWD     M+KP Y+I+YE  MT+W DI   L ++ V R  + Y L +VV H G IS GHYV YR +R  W+ V DE V  ++F   I PYILIYEK+
Sbjct:    6 KNISKTSCCNLLCSFTCRN--KRPGSIYNTSSKCYMISVIQAIAASDILIAQFEDIYDKYPNCSSLGYLIDLLRGVIRKGRYKKNRSENTQILNQLILEIKWNKCSQQDAFEIMTAIWKSISDNLKIYG--KFFLPMKIKLIHSFKGIDVTNKIQNYLGLSLGLCGNYHERPGVILEYLIDQHFQPSLIDGNPNKTSNITIYEKAPEILLLHIQANKWDDFSGVMVKPIYYILYEENMTLWLDIAQDLMRNKVHRQKLVYNLKSVVSHSGNISQGHYVTYRTFRGKWFKVDDETVTEIQFDKKISPYILIYEKL 315          
The following BLAST results are available for this feature:
BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 1
Match NameE-valueIdentityDescription
usp332.208e-631.33ubiquitin specific peptidase 33 [Source:NCBI gene;... [more]
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
M7WCD82.175e-725.60Ubiquitin carboxyl-terminal hydrolase, putative OS... [more]
N9UVY32.175e-725.60Ubiquitin carboxyl-terminal hydrolase, putative OS... [more]
M2RXF32.175e-725.60Ubiquitin carboxylterminal hydrolase, putative OS=... [more]
M3UQH12.175e-725.60Ubiquitin carboxyl-terminal hydrolase domain conta... [more]
C4LXH72.175e-725.60Ubiquitin carboxyl-terminal hydrolase, putative OS... [more]
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
UBP13.512e-646.51Ubiquitin-specific protease; removes ubiquitin fro... [more]
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Ubiquitinyl hydrolase 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000057792.10.000e+098.32SMESG000057792.1[more]
SMESG000057788.11.321e-10393.79SMESG000057788.1[more]
SMESG000057788.11.477e-10294.94SMESG000057788.1[more]
SMESG000057810.15.850e-7743.89SMESG000057810.1[more]
SMESG000057791.19.871e-7744.27SMESG000057791.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020178 ID=SMED30020178|Name=Ubiquitinyl hydrolase 1|organism=Schmidtea mediterranea sexual|type=transcript|length=1815bp
TTATTTTGATGATAATTCATTTATTTTCAACCTTGCCAAAGATCAAATCT
TTTAATTCTGCAAGATGCAAAATTTTGATCTGTTGTTAGAATGAAATGTA
ATGAAATATCAACAAAAAAAGAAAACAGATCAATGGTGACAAAACAAATA
AAAAGTTTTAATACTTGAAGAAAAATTTGATTTTAATTTTCAGTGAAAAT
TTAAACGAAAACAATTTAAAAAAGAATTTAATTGAATTTTTAAAGGTTTC
AAGAATGGTTTCGATTGACTTTCACGCTGTAGATTATTGGTTGTATGTGT
CTTTAATTTTAATCATGATCCTGGTGATAATTTTTTTGGTTGGAATAATT
TGTTTCTGCATTTATCACTATCGACAAAAGATCCGAAAGCTCCTAATTTG
TGAAAAAATCGTTCCATTTTCTACTGGCTATATTTATGATAAACCGAGTG
GATTCAAGAATTTGGCGGAAACTTGCTACATGAATGCAATCATACAAGCA
GCAGCCTCAAGTCAGATACTGATAAGCCAATTTCAACATTTACACGAAAC
CTATAAAGAGTCAATGAGTTTAAAATGCTTTTATGATGTCCTCATAGGCG
TGAACACTCCAGATGATTCGTATGAACGCTTGTGTAAGAATACCAATCAG
TTGGAGACATTAATCCGATTAGTAAACTGGACAAAAACAAATCAACAAGA
TGCGTTCGAGCTTTTCACTGTCCTTATCAAAGGAATCAGTGACGAATTCA
AAGCTCAAAATATAGATGATATTGAAATGCCGCTGAAACTGAAAATGGTA
TATAGATTTAAAGGCCTAGATATTCCAGATAGGACGCAATATCATCTTGG
GCTTTCCCTGGGACTAAGTGGGCCATATGAAACTAAACCAGGAGTAACGT
TGGAATTTCTAATTTTGGAACATTTCTCACCAACACTTATTGACGGAGAT
CCGAATAAAACGTCGCAATTGTTTTTTCTTAAAGATGCCCCAGATGTTTT
ACTTCTTCACATTCAAGCTAATAAATGGGATTCTGTGAAGGAGAAAATGA
TAAAACCAAAATACCATATTGTATACGAACGAGAAATGACAATCTGGTTT
GACATAATCACAGCCTTGAACAAGGACAATGTTAAACGCATATCAGTCAC
ATATAGACTTACAGCAGTTGTGCAACACATGGGGACAATTTCCGGGGGCC
ATTACGTAGCCTACAGGAAATGGAGAAACAATTGGTATTTGGTTAGCGAT
GAACAAGTCGAATTAATGGAGTTCAGTGGGAATATTTGTCCATATATTTT
GATCTATGAGAAGATAGGATCTGCGGAATAGGAATAATTGTAAAATAGAT
CAAGCTTTCATTTTAACATGCATATAATAATGGAAACGTTTAGTTGGTTC
TAATGTGGCTAAATGCTCGAAATTTTGTATTTCAGTTTTATTTTATGGTT
CCAAGCTTTGCTTTGAATAAATTCTTTAACAAACAAAACATTTTTCTTTA
ATTTCATGTTTTTATACTTTTCTTTCGTTTTTCTTCAATTTTTTTTCTCT
AAATTTATCGATAGTATCCACAGCCAAACTACTTCACAGTGCACAAAGAA
AAAGATTTTAAAATATTATCAATCTCATTAGACATTCAAAACATTTCCCA
CAATTATCTGACGTCGCTTTTGATATAATTCTTCTCGGTGAAAGTGGGAG
CGAGTTCATCATTACCCTTTTTGTAAAATCTTTTATCTTTCTCACCTGTT
ATCTACATTCAATGTTCTTTTGTTGATTTGATTTCTAACTTAATAAAATT
TTTCTTTGTCTAAAT
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protein sequence of SMED30020178-orf-1

>SMED30020178-orf-1 ID=SMED30020178-orf-1|Name=SMED30020178-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=359bp
MVSIDFHAVDYWLYVSLILIMILVIIFLVGIICFCIYHYRQKIRKLLICE
KIVPFSTGYIYDKPSGFKNLAETCYMNAIIQAAASSQILISQFQHLHETY
KESMSLKCFYDVLIGVNTPDDSYERLCKNTNQLETLIRLVNWTKTNQQDA
FELFTVLIKGISDEFKAQNIDDIEMPLKLKMVYRFKGLDIPDRTQYHLGL
SLGLSGPYETKPGVTLEFLILEHFSPTLIDGDPNKTSQLFFLKDAPDVLL
LHIQANKWDSVKEKMIKPKYHIVYEREMTIWFDIITALNKDNVKRISVTY
RLTAVVQHMGTISGGHYVAYRKWRNNWYLVSDEQVELMEFSGNICPYILI
YEKIGSAE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
GO:0016579protein deubiquitination
GO:0006511ubiquitin-dependent protein catabolic process
Vocabulary: molecular function
TermDefinition
GO:0008233peptidase activity
GO:0008234cysteine-type peptidase activity
GO:0008270zinc ion binding
GO:0046872metal ion binding
GO:0036459thiol-dependent ubiquitinyl hydrolase activity
GO:0016787hydrolase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000034epidermis
PLANA:0000099neuron
PLANA:0002032epidermal cell
PLANA:0002089reproductive organ
Vocabulary: INTERPRO
TermDefinition
IPR038765Papain-like_cys_pep_sf
IPR001394Peptidase_C19_UCH
IPR018200USP_CS
IPR028889USP_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001394Peptidase C19, ubiquitin carboxyl-terminal hydrolasePFAMPF00443UCHcoord: 66..351
e-value: 6.5E-25
score: 88.1
NoneNo IPR availableGENE3DG3DSA:3.90.70.10coord: 66..356
e-value: 1.2E-36
score: 128.7
NoneNo IPR availablePANTHERPTHR24006FAMILY NOT NAMEDcoord: 62..353
NoneNo IPR availableCDDcd02257Peptidase_C19coord: 66..352
e-value: 2.43404E-22
score: 92.5462
NoneNo IPR availableTMHMMTMhelixcoord: 15..37
IPR018200Ubiquitin specific protease, conserved sitePROSITEPS00973USP_2coord: 300..317
IPR028889Ubiquitin specific protease domainPROSITEPS50235USP_3coord: 65..354
score: 22.422
IPR038765Papain-like cysteine peptidase superfamilySUPERFAMILYSSF54001Cysteine proteinasescoord: 63..354