Coiled-coil domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020166 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 11
Homology
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Match: A0A4E0RDV3 (Coiled-coil domain-containing protein OS=Fasciola hepatica OX=6192 GN=D915_004566 PE=4 SV=1) HSP 1 Score: 66.6254 bits (161), Expect = 4.683e-8 Identity = 27/47 (57.45%), Postives = 33/47 (70.21%), Query Frame = 3 Query: 114 QIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDE 254 ++P I+LNNFD F YVLTSP SLEAC N+NIKP +LL + E Sbjct: 10 EVPNIDLNNFDDPGFVGSRYVLTSPRSLEACANMNIKPVDLLPKSKE 56
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Match: A0A504YZI1 (Uncharacterized protein OS=Fasciola gigantica OX=46835 GN=FGIG_12448 PE=4 SV=1) HSP 1 Score: 62.7734 bits (151), Expect = 1.086e-7 Identity = 27/47 (57.45%), Postives = 34/47 (72.34%), Query Frame = 3 Query: 114 QIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDE 254 ++P I+LNNFD +F YVLTSP SLEAC N+NIKP +LL + E Sbjct: 10 EVPNIDLNNFDDPSFVASRYVLTSPRSLEACANMNIKPVDLLPKSKE 56
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Match: A0A4S2L7D4 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009465 PE=4 SV=1) HSP 1 Score: 65.0846 bits (157), Expect = 1.182e-7 Identity = 48/150 (32.00%), Postives = 84/150 (56.00%), Query Frame = 3 Query: 708 EKKAINVSHRRKQIEDEILIYYRELERFQNIT---------IKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQV 1130 E++ RR+++E + Y REL+ + IT ++S+EE+ +K+Q Q + Q+ RE +++ + E R E M K +E+ FL+E+ K+ ESR LA A+++R E++++YNLDSFD+KA +VN++ Sbjct: 264 ERRLRQAQERRRELEKMLETYRRELQEAREITHQRARERAYLRSSEEQL-RKVQDRQQREQHIRENAKIIQQRQEEW------RRAAEAMQK--QKEEHVQKFLEEREAKIQESRNLAQAAEQLRAEMQRVYNLDSFDKKAQHVALVNEL 404 HSP 2 Score: 63.1586 bits (152), Expect = 5.431e-7 Identity = 27/40 (67.50%), Postives = 29/40 (72.50%), Query Frame = 3 Query: 120 PQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELL 239 P INL NFD F +C YVLTSP SLEAC LNI+P ELL Sbjct: 12 PDINLYNFDDPQFQSCRYVLTSPRSLEACARLNIRPVELL 51
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Match: A0A4V3SD13 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009465 PE=4 SV=1) HSP 1 Score: 64.6994 bits (156), Expect = 1.841e-7 Identity = 48/150 (32.00%), Postives = 84/150 (56.00%), Query Frame = 3 Query: 708 EKKAINVSHRRKQIEDEILIYYRELERFQNIT---------IKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQV 1130 E++ RR+++E + Y REL+ + IT ++S+EE+ +K+Q Q + Q+ RE +++ + E R E M K +E+ FL+E+ K+ ESR LA A+++R E++++YNLDSFD+KA +VN++ Sbjct: 297 ERRLRQAQERRRELEKMLETYRRELQEAREITHQRARERAYLRSSEEQL-RKVQDRQQREQHIRENAKIIQQRQEEW------RRAAEAMQK--QKEEHVQKFLEEREAKIQESRNLAQAAEQLRAEMQRVYNLDSFDKKAQHVALVNEL 437 HSP 2 Score: 63.1586 bits (152), Expect = 5.788e-7 Identity = 27/40 (67.50%), Postives = 29/40 (72.50%), Query Frame = 3 Query: 120 PQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELL 239 P INL NFD F +C YVLTSP SLEAC LNI+P ELL Sbjct: 12 PDINLYNFDDPQFQSCRYVLTSPRSLEACARLNIRPVELL 51
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Match: A0A4S2L6P1 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009465 PE=4 SV=1) HSP 1 Score: 64.3142 bits (155), Expect = 2.045e-7 Identity = 48/150 (32.00%), Postives = 84/150 (56.00%), Query Frame = 3 Query: 708 EKKAINVSHRRKQIEDEILIYYRELERFQNIT---------IKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQV 1130 E++ RR+++E + Y REL+ + IT ++S+EE+ +K+Q Q + Q+ RE +++ + E R E M K +E+ FL+E+ K+ ESR LA A+++R E++++YNLDSFD+KA +VN++ Sbjct: 268 ERRLRQAQERRRELEKMLETYRRELQEAREITHQRARERAYLRSSEEQL-RKVQDRQQREQHIRENAKIIQQRQEEW------RRAAEAMQK--QKEEHVQKFLEEREAKIQESRNLAQAAEQLRAEMQRVYNLDSFDKKAQHVALVNEL 408 HSP 2 Score: 63.1586 bits (152), Expect = 4.601e-7 Identity = 27/40 (67.50%), Postives = 29/40 (72.50%), Query Frame = 3 Query: 120 PQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELL 239 P INL NFD F +C YVLTSP SLEAC LNI+P ELL Sbjct: 12 PDINLYNFDDPQFQSCRYVLTSPRSLEACARLNIRPVELL 51
BLAST of Coiled-coil domain-containing protein vs. Ensembl Medaka
Match: ENSORLT00000012507.2 (coiled-coil domain containing 177 [Source:NCBI gene;Acc:101172777]) HSP 1 Score: 51.6026 bits (122), Expect = 1.376e-6 Identity = 24/45 (53.33%), Postives = 27/45 (60.00%), Query Frame = 3 Query: 105 DLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELL 239 DL ++L NFDS A YVLTSP SLEAC +KP ELL Sbjct: 85 DLPPKMHLDLYNFDSPAAEGSRYVLTSPRSLEACARCGVKPVELL 129
BLAST of Coiled-coil domain-containing protein vs. Planmine SMEST
Match: SMESG000005080.1 (SMESG000005080.1) HSP 1 Score: 613.994 bits (1582), Expect = 0.000e+0 Identity = 346/350 (98.86%), Postives = 348/350 (99.43%), Query Frame = 3 Query: 93 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPXXXXXXXXXXXXXXXXXXERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKDYHYLSQDKHERNSNNKLRRRISMQDEKKTNSFTRELSFHXXXXXXXXXXXXXXXXLCRQMKIRISRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV 1142 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPEKEKREKERKLKILRAKIERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKD HYLSQDKHERNS NKLRRRISMQDEKKTNSFTRELSFHEKRRELEEQAKREKEELC+QMKIR+SRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV Sbjct: 1 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPEKEKREKERKLKILRAKIERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKDDHYLSQDKHERNSINKLRRRISMQDEKKTNSFTRELSFHEKRRELEEQAKREKEELCQQMKIRMSRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV 350
BLAST of Coiled-coil domain-containing protein vs. Planmine SMEST
Match: SMESG000005080.1 (SMESG000005080.1) HSP 1 Score: 608.986 bits (1569), Expect = 0.000e+0 Identity = 346/353 (98.02%), Postives = 348/353 (98.58%), Query Frame = 3 Query: 93 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPXXXXXXXXXXXXXXXXXXERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKDYHYLSQDKHERNSNNKLRRRISMQ---DEKKTNSFTRELSFHXXXXXXXXXXXXXXXXLCRQMKIRISRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV 1142 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPEKEKREKERKLKILRAKIERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKD HYLSQDKHERNS NKLRRRISMQ DEKKTNSFTRELSFHEKRRELEEQAKREKEELC+QMKIR+SRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV Sbjct: 1 MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAEYDENAVYNPEKEKREKERKLKILRAKIERQRLINEICSSKSQLMVEGKLLGPDKNNQAKGISDKDDHYLSQDKHERNSINKLRRRISMQKTKDEKKTNSFTRELSFHEKRRELEEQAKREKEELCQQMKIRMSRVERNRMELQMKKNREIEVKRRSEEKKAINVSHRRKQIEDEILIYYRELERFQNITIKSAEEKFQKKLQAEQNKIQYEREYKELVNRHNRELIVEQDTNRICETMVKIIDREKQNDMFLQEKLNKMIESRCLANEAQKVREEIRKIYNLDSFDRKAVQAEIVNQVMKSV 353 The following BLAST results are available for this feature:
BLAST of Coiled-coil domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Coiled-coil domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Coiled-coil domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of Coiled-coil domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020166 ID=SMED30020166|Name=Coiled-coil domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1317bpback to top protein sequence of SMED30020166-orf-1 >SMED30020166-orf-1 ID=SMED30020166-orf-1|Name=SMED30020166-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=351bp MSKLDLHQIPQINLNNFDSDAFYNCEYVLTSPTSLEACKNLNIKPAELLAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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