Serine/threonine-protein kinase PLK
|
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30020085 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 2
Homology
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK1 (polo like kinase 1 [Source:HGNC Symbol;Acc:HGNC:9077]) HSP 1 Score: 162.155 bits (409), Expect = 1.091e-41 Identity = 143/521 (27.45%), Postives = 236/521 (45.30%), Query Frame = 1
Query: 382 LGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDH----SMGFQLSMESIVFISDQPVI------------DAINNL--------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
LGKG F +CFEI D +E + ++V +L P ++E + EI+IH+ + ++++V H D + V +++ELC RSL + + ++ A I G YLH + ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ P SI P + + + + G + + ++PV+ D + L SER ++ ED I WVS+W + Y L + S+G + +++ D + + D T + LT S+ I +LK F Y+ + +L + + + PR +L ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQREKMSMEISIHRSLAHQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNR-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESY--------LTVSSHPNSLMKKITLLKYFRNYMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLIL 543
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK2 (polo like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19699]) HSP 1 Score: 152.91 bits (385), Expect = 2.664e-38 Identity = 94/314 (29.94%), Postives = 154/314 (49.04%), Query Frame = 1
Query: 322 SISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLS 1257
+IS +++ + + LGKG F +C+E+ N+ A K IP ++E ++EI +H+ + +K++V+ + D ++ +++E C RS+A + L + I GL YLH EQ I+HRD+K N +NE + K+ DFGLA E + + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L K+P+ RP L D++ DF+ + P+ C F LS
Sbjct: 54 AISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNK----VYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF-LQGFTPDRLSSSCCHTVPDFHLS 343
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK2 (polo like kinase 2 [Source:HGNC Symbol;Acc:HGNC:19699]) HSP 1 Score: 151.754 bits (382), Expect = 6.185e-38 Identity = 94/313 (30.03%), Postives = 153/313 (48.88%), Query Frame = 1
Query: 325 ISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLS 1257
IS +++ + + LGKG F +C+E+ N+ A K IP ++E ++EI +H+ + +K++V+ + D ++ +++E C RS+A + L + I GL YLH EQ I+HRD+K N +NE + K+ DFGLA E + + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L K+P+ RP L D++ DF+ + P+ C F LS
Sbjct: 69 ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNK----VYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF-LQGFTPDRLSSSCCHTVPDFHLS 357
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PLK3 (polo like kinase 3 [Source:HGNC Symbol;Acc:HGNC:2154]) HSP 1 Score: 145.206 bits (365), Expect = 8.195e-36 Identity = 92/299 (30.77%), Postives = 152/299 (50.84%), Query Frame = 1
Query: 322 SISNKLLESFNYNKIVLK-RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPE 1209
S +L+ + LK R LGKG F +C+E E S A+K IP ++E EI +H+ + +++IV+ D + ++ + +ELC +SLA ++ L+P + I GL YLH ++GI+HRD+K N + E + K+ DFGLA E +Q K ICGTP+Y+APE+ + GH ++D+W+ G +Y ++ G PFET +++ Y+ + + Y P S L +++ + IL+ P+ RP + +L DF+ TK P+
Sbjct: 47 SDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGS----AYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTL-LEP-EVRYYLRQILSGLKYLH-QRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKET--------------YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFF-TKGYTPD 321
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Match: PNCK (pregnancy up-regulated nonubiquitous CaM kinase [Source:HGNC Symbol;Acc:HGNC:13415]) HSP 1 Score: 119.013 bits (297), Expect = 1.216e-28 Identity = 87/269 (32.34%), Postives = 129/269 (47.96%), Query Frame = 1
Query: 370 LKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLN---EKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPL------CSKRFIKGILQKDPQKR 1149
++ LG GAF + + QE S LV ALK IP K+ L EIA+ +++ + IV L V+ P + + MEL L D I + GS K A + + + + YLH GIVHRD+KP N+L E +SDFGL+ Q CGTP Y+APE+ +Q + D+WA GV Y ++ GY PF + + ++ ++R Y+F +P +K FI+ +L++DPQKR
Sbjct: 17 IRERLGSGAFSEV--VLAQERGSAHLV--ALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESP--SHLYLAMELVTGGELFDRIMERGSYTEKDA--SHLVGQVLGAVSYLH-SLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKI--QAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPE--------------LFSQILRASYEF--DSPFWDDISESAKDFIRHLLERDPQKR 258
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-3 (Serine/threonine-protein kinase plk-3 [Source:UniProtKB/Swiss-Prot;Acc:Q20845]) HSP 1 Score: 152.14 bits (383), Expect = 9.636e-39 Identity = 139/529 (26.28%), Postives = 229/529 (43.29%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIY--DSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKIC--GTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPT--KSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVI---------------------------DAINNLSERISYIPQKV-------------------EDIIWVSRWAMKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQ-----TINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILAS--LLSTLKPRPNLKL--NMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFI 1785
LG+G F CFE +++ N+ ++A+K +P I + +E RE+ IH+++ ++ IV+ H D S +V +ELC SL + Q G + A + + G+ +LH+ Q I+HRD+K N+ LNE + KI DFGLAT C++ + K+ GTP+Y+APE+ + GH+F+ DIWA G LY ++ G PFE S +Q+T Y + Y P++A + R I+ +L P +RP +L F+ T + YP + H + + + + ++ ++P+ D ++ L +IS+I Q V I WVS+W Y L S G + + V + F E+ T+N + + + IN + ++ M + A ++ + P N +QN WF +VIF LSNG QI+F DH K+ +
Sbjct: 41 LGEGGFAHCFE--FRKLDCND--RLAVKVVPKVILLKSTAREKLTREVEIHRQLSHRNIVQFHHFFED--SQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTI--QVAEGVKHLHNLQ-IIHRDLKLGNLFLNEHLQVKIGDFGLATF---CEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCILYVLLFGSPPFE----------SRRVQET----YVRIKNNDYVVPENASPTANRLIRSLLDPVPDRRPTAEAVLLDQFFKTTIEPTYPPVHQQLHKEQDVKYFAPINPVLPHVEEPISPIYQEVANEETSEIRRFVKTEQASSFGDELSQLQAQISHILQNVVASKNKSSTRFGLNHSPEATPIFWVSQWVHFPNHGIGYRLCENSSGMLFNDNTQMKVNSAGNQLTFVDENNTEQFYTMNDQVPMNLQ----TKINIFSNVQSYMNTHLEADTHLEAEDQCVNKVPPLRNFARLPTIQN-------WFETKSAVIFHLSNGTVQINFLDHVKMVL 532
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-3 (Serine/threonine-protein kinase plk-3 [Source:UniProtKB/Swiss-Prot;Acc:Q20845]) HSP 1 Score: 152.14 bits (383), Expect = 9.636e-39 Identity = 139/529 (26.28%), Postives = 229/529 (43.29%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIY--DSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKIC--GTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPT--KSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVI---------------------------DAINNLSERISYIPQKV-------------------EDIIWVSRWAMKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQ-----TINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILAS--LLSTLKPRPNLKL--NMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFI 1785
LG+G F CFE +++ N+ ++A+K +P I + +E RE+ IH+++ ++ IV+ H D S +V +ELC SL + Q G + A + + G+ +LH+ Q I+HRD+K N+ LNE + KI DFGLAT C++ + K+ GTP+Y+APE+ + GH+F+ DIWA G LY ++ G PFE S +Q+T Y + Y P++A + R I+ +L P +RP +L F+ T + YP + H + + + + ++ ++P+ D ++ L +IS+I Q V I WVS+W Y L S G + + V + F E+ T+N + + + IN + ++ M + A ++ + P N +QN WF +VIF LSNG QI+F DH K+ +
Sbjct: 41 LGEGGFAHCFE--FRKLDCND--RLAVKVVPKVILLKSTAREKLTREVEIHRQLSHRNIVQFHHFFED--SQNVYFTLELCSKNSLMELNKQRGPLTEHEARFYTI--QVAEGVKHLHNLQ-IIHRDLKLGNLFLNEHLQVKIGDFGLATF---CEKNEKKMTRGGTPNYIAPEVLNETGHAFEVDIWAIGCILYVLLFGSPPFE----------SRRVQET----YVRIKNNDYVVPENASPTANRLIRSLLDPVPDRRPTAEAVLLDQFFKTTIEPTYPPVHQQLHKEQDVKYFAPINPVLPHVEEPISPIYQEVANEETSEIRRFVKTEQASSFGDELSQLQAQISHILQNVVASKNKSSTRFGLNHSPEATPIFWVSQWVHFPNHGIGYRLCENSSGMLFNDNTQMKVNSAGNQLTFVDENNTEQFYTMNDQVPMNLQ----TKINIFSNVQSYMNTHLEADTHLEAEDQCVNKVPPLRNFARLPTIQN-------WFETKSAVIFHLSNGTVQINFLDHVKMVL 532
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-2 (Serine/threonine-protein kinase plk-2 [Source:UniProtKB/Swiss-Prot;Acc:Q9N2L7]) HSP 1 Score: 147.132 bits (370), Expect = 5.704e-37 Identity = 139/540 (25.74%), Postives = 232/540 (42.96%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPR-------------------------LIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQ-LSMESIVFIS--------------DQPVIDAINNLSERI-------------------SYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVT--------LDKKET-HFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
LGKG F C+E+ + S+ EL A K +P I +++ +E+ IH+ + ++ +VKL+ D +V + +ELC RSL + + ++ A I G++YLH+ + IVHRD+K N+ LN+++ KI DFGLATT + + K +CGTP+Y+APE+ + GHSF+ D+WA G LY ++ G+ PFE S SL++T Y + Y P SA + + I+ +L P +RP ++ L D Y +++ P D+ H G LS +S QP ++NL ++ SY + + W+S+W + Y L + S+G + I++ ++K E H+ + I S L +K L +Y D +++ Q + + L P L++ WF +++ LSNG QI+ F+DH K+ +
Sbjct: 42 LGKGGFAHCYEL--RNKSTGEL--FAGKVVPKALLIKQYQRDKMAQEVQIHRNLQHRNVVKLYHFFED--KSNVYITLELCPRRSLMELHKRRKAVTEPEARY--FTYQIVEGVLYLHNLK-IVHRDLKLGNLFLNDELQVKIGDFGLATTCDN-DERKKTLCGTPNYIAPEVLNKIGHSFEVDLWAIGCILYILLFGHPPFE----------SKSLEET----YSRIKNNNYVIPTSASAAASQLIRVLLDPVPSRRPNARAVCRDHFFKSGFMPARLPVSCLTMVPHLNDDEYAEENVSPSGTIDQRGPHQAGRSGLSAIPAHLVSRNSERQQTHRMEAYRQPTDCYLSNLLAQVNDLLATPTADIDDAEAALDSYQSPEALPVFWISKWVDYSDKYGIGYQLCDNSVGVLFNDNSRIMLDTAGTQLTYIEKTEKEHYFDMESAIPSGLQKKMTLLKYFR-SYMNDHLLQA------GQQVTRKVGDDLARLPTLRV-----------WFRTKSAIVLHLSNGTVQINFFNDHIKMVL 539
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-1 (Serine/threonine-protein kinase plk-1 [Source:UniProtKB/Swiss-Prot;Acc:P34331]) HSP 1 Score: 139.428 bits (350), Expect = 2.244e-34 Identity = 89/272 (32.72%), Postives = 142/272 (52.21%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY 1185
R LGKG F C+E+ ++ E+V A K +P + +++ +E+ IH+++ + IVKL D + +V + +ELC RSL + + ++ A + I G++YLH + I+HRD+K N+ LN+ + KI DFGLATT + K +CGTP+Y+APE+ + GHSF+ DIWA G LY ++ G PFE S SL++T + + N Y P A + I+ +L +P +RP + F+
Sbjct: 42 RFLGKGGFAHCYEL--TNRATREVV--AGKVVPKSMLVKQYQRDKMTQEVQIHRELGHINIVKLFNFFEDNL--NVYITLELCARRSLMELHKRRKAVTEPEARY--FTHQIVDGVLYLH-DLNIIHRDMKLGNLFLNDDLVVKIGDFGLATT-VNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFE----------SKSLEETYSRIRHN----NYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF 289
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Match: plk-1 (Serine/threonine-protein kinase plk-1 [Source:UniProtKB/Swiss-Prot;Acc:P34331]) HSP 1 Score: 137.887 bits (346), Expect = 8.108e-34 Identity = 90/273 (32.97%), Postives = 141/273 (51.65%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS---KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY 1185
R LGKG F C+E+ ++ E+V A K +P + + ++ N I IH+++ + IVKL D + +V + +ELC RSL + + ++ A + I G++YLH + I+HRD+K N+ LN+ + KI DFGLATT + K +CGTP+Y+APE+ + GHSF+ DIWA G LY ++ G PFE S SL++T + + N Y P A + I+ +L +P +RP + F+
Sbjct: 42 RFLGKGGFAHCYEL--TNRATREVV--AGKVVPKSMLVKQYQRDKVDNERILIHRELGHINIVKLFNFFEDNL--NVYITLELCARRSLMELHKRRKAVTEPEARY--FTHQIVDGVLYLH-DLNIIHRDMKLGNLFLNDDLVVKIGDFGLATT-VNGDERKKTLCGTPNYIAPEVLNKAGHSFEVDIWAVGCILYILLFGQPPFE----------SKSLEETYSRIRHN----NYTIPSIATQPAASLIRKMLDPEPTRRPTAKQVQRDGFF 290
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: polo (gene:FBgn0003124 transcript:FBtr0074839) HSP 1 Score: 149.058 bits (375), Expect = 1.034e-37 Identity = 134/531 (25.24%), Postives = 226/531 (42.56%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENS---SNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY---------------------------------PTKSIYPETPEDEHCD--------------------HSMGFQLSMESIV-----FISDQPVIDAINNLSERISYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF-YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKL 1779
R GKG F +C+EI E + ++V L I ++KE +EI IH+ + + IVK H D S ++ +++ELC RS+ + + SI I +G+ YLH + I+HRD+K N+ LN+ + KI DFGLAT E + K +CGTP+Y+APEI + GHSF+ DIW+ G +Y ++ G PFET+ +D+ Y + + +Y+ P + + +LQ +P+ RP + LL +F P + P+D + HS ++ +ES+ I+ +P I N E Q + W+S+W + F Y L + IG + +++ ++ HF +D K +T ++ YC + K +K Y + ++ L+ N++ + + ++ WF +V+ L+NG Q++F DH KL
Sbjct: 29 RFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLM-----IKHNQKEKTAQEITIHRSLNHPNIVKFHNYFED--SQNIYIVLELCKKRSMMELHKRRKSI--TEFECRYYIYQIIQGVKYLH-DNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDT--------------YSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPL---FWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDG--------KETYMTTTD---YCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNFSDHMKL 521
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: polo (gene:FBgn0003124 transcript:FBtr0100318) HSP 1 Score: 149.058 bits (375), Expect = 1.034e-37 Identity = 134/531 (25.24%), Postives = 226/531 (42.56%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENS---SNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY---------------------------------PTKSIYPETPEDEHCD--------------------HSMGFQLSMESIV-----FISDQPVIDAINNLSERISYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF-YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKL 1779
R GKG F +C+EI E + ++V L I ++KE +EI IH+ + + IVK H D S ++ +++ELC RS+ + + SI I +G+ YLH + I+HRD+K N+ LN+ + KI DFGLAT E + K +CGTP+Y+APEI + GHSF+ DIW+ G +Y ++ G PFET+ +D+ Y + + +Y+ P + + +LQ +P+ RP + LL +F P + P+D + HS ++ +ES+ I+ +P I N E Q + W+S+W + F Y L + IG + +++ ++ HF +D K +T ++ YC + K +K Y + ++ L+ N++ + + ++ WF +V+ L+NG Q++F DH KL
Sbjct: 29 RFFGKGGFAKCYEIIDVETDDVFAGKIVSKKLM-----IKHNQKEKTAQEITIHRSLNHPNIVKFHNYFED--SQNIYIVLELCKKRSMMELHKRRKSI--TEFECRYYIYQIIQGVKYLH-DNRIIHRDLKLGNLFLNDLLHVKIGDFGLATRIEYEGERKKTLCGTPNYIAPEILTKKGHSFEVDIWSIGCVMYTLLVGQPPFETKTLKDT--------------YSKIKKCEYRVPSYLRKPAADMVIAMLQPNPESRPAIGQLLNFEFLKGSKVPMFLPSSCLTMAPRIGSNDTIEDSMHRKPLMEMNGIRPDDTRLESTFLKANLHDAITASAQVCRHSEDYRSDIESLYQQLTNLINGKPRILQGNLGDENTDPAAQPL---FWISKWVDYSDKYGFGYQLCDEGIGVMFNDTTKLILLPNQINVHFIDKDG--------KETYMTTTD---YCKSLDKKMKLLSYFKRYMIEHLVKAGANNVNIESDQISRMPHLHSWFRTTCAVVMHLTNGSVQLNFSDHMKL 521
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: SAK (gene:FBgn0026371 transcript:FBtr0078387) HSP 1 Score: 112.464 bits (280), Expect = 2.081e-25 Identity = 71/267 (26.59%), Postives = 130/267 (48.69%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
LGKG F ++ + ++M K + G + + +E+ IH ++ + +++L+ D + V +++EL +N L ++N + + GL+YLH I+HRDI +N+LL+ ++ KI+DFGLAT ++ + +CGTP+Y++PE+ + H +D+W+ G LY ++ G PFET + ++NK V+ +Y P ++ I +L+K P +R L +L F
Sbjct: 20 LGKGGFATVYKARCLHTHQDVAIKMIDKKLIQGTGLTNR--VRQEVEIHSRLKHPSVLQLYTFFQD--ANYVYLVLELAHNGELHRYMNHIAR-PFTETEAASILKQVVAGLLYLH-SHNIMHRDISLSNLLLSREMHVKIADFGLATQLKRPDERHMTMCGTPNYISPEVVSRTSHGLPADVWSVGCMLYTLLVGRPPFETDAVQSTLNK--------------VVMSEYIMPAHLSYEAQDLINKLLKKLPHERITLEAVLCHPF 266
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: CaMKI (gene:FBgn0016126 transcript:FBtr0333670) HSP 1 Score: 101.679 bits (252), Expect = 8.239e-23 Identity = 84/294 (28.57%), Postives = 136/294 (46.26%), Query Frame = 1
Query: 289 SFKDMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILL---NEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPK----SAPLCSKRFIKGILQKDPQKR 1149
S K K ++K ++ ++ YN L LG GAF E+ E+ + A+K I K+E EI + +++ + IV+L + D V ++MEL L D I + GS K A + + I + Y+H EQG+VHRD+KP N+L ++ ISDFGL+ + CGTP Y+APE+ Q + D+W+ GV Y ++ GY PF + N +N ++ +++G ++F +K FIK ++ +KR
Sbjct: 9 SGKKAKAKDLKELNKQVSIEEKYN---LHGLLGTGAFS---EVRLAESKDSPGEHFAVKIIDKKALKGKEESLENEIRVLRRLTHPNIVQLLETYED--KSKVYLVMELVTGGELFDRIVEKGSYTEKDA--SHLIRQILEAVDYMH-EQGVVHRDLKPENLLYYSPDDDSKIMISDFGLSKMEDSGIMAT--ACGTPGYVAPEVLAQKPYGKAVDVWSIGVISYILLCGYPPFYDE------NDAN--------LFAQILKGDFEFDSPYWDEISESAKHFIKNLMCVTVEKR 275
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Match: S6kII (gene:FBgn0262866 transcript:FBtr0333715) HSP 1 Score: 103.99 bits (258), Expect = 1.358e-22 Identity = 72/281 (25.62%), Postives = 136/281 (48.40%), Query Frame = 1
Query: 313 EIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEID--WQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKR 1149
E+K + + + + ++ L R LG+G+FG+ F + +++ LK + D + R+I + + +IV+LH P G + +I++ L F + + + + + +LH GI++RD+KP NILL+E ++DFGL+ P +T + CGT Y+APEI + GH F +D W+FGV +Y M+ G PF Q +++++N+ ++R K P++ ++ ++ + +++PQ R
Sbjct: 182 ELKEVIKEGHDKADPSQFELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILA--DVGHAFIVRLHYAFQTP--GKLYLILDFLRGGDL--FTRLSKEVMFTEEDVKFYLAELALAMNHLH-TLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKT-YSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQ--------------ILRSKLGMPENLSPEAQSLLRALFKRNPQNR 440 HSP 2 Score: 87.0409 bits (214), Expect = 2.284e-17 Identity = 74/280 (26.43%), Postives = 127/280 (45.36%), Query Frame = 1
Query: 370 LKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNK-YIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANIL-LNEKISP---KISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSA----PLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
L + LG+G F C + + + + V++ K S E+ I + N IV L+ V D +G ++MEL L D I G + A + V I + YLH E G+VHRD+KP+N++ + + +P K+ D G A C T +++APE+ ++ G+ DIW+ GV LY M++G TPF +++ + ++ + + G+ F S + +K ++ +L P+ RP +LE D+
Sbjct: 570 LLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYED--AGSAYLVMELLKGGELLDRILAVGQMCESEA--SAVLRTIASAVAYLH-EHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPF-----------ASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDW 833
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk1 (polo-like kinase 1 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-021115-7]) HSP 1 Score: 162.925 bits (411), Expect = 3.454e-42 Identity = 140/554 (25.27%), Postives = 243/554 (43.86%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPET-----------------------------PEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I + L++ + + R LGKG F +C+EI D +E + ++V ++ P +KE + EIAIH+ + N ++V H D V +++E+C RSL + + ++ A +G+ YLH+ + ++HRD+K N+ LN+ + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ DIW+ G LY ++ G PFET + L++T Y + + +Y P+ + I+ +L DP RP + +LL +F+ P SI P + P+ E G + + + Q + S+R ++ ED + W+S+W + Y L++ S+G + +++ D + + + R + PS ++ I +LK F Y+ + +L + + + PR +L ++ WF +++ LSNG QI+ F DHTKL +
Sbjct: 17 DPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKP-----HQKEKMSTEIAIHKSLDNPHVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--FMRQTIQGVQYLHNNR-VIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFET----------SCLKET----YIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPRFSIAPSSLDPALLRKPLSSLNKGTDSPIEKMGKMDQPQREDLQQRDGPEQPDTHLTDMLQQLAVVNAAKPSDRDFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYIDRNSLESYLSVRSY----PSALSKK----ITLLKYFRNYMSEHLLKA-GANITPREGDELTRLP---YLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLIL 534
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk1 (polo-like kinase 1 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-021115-7]) HSP 1 Score: 162.925 bits (411), Expect = 3.454e-42 Identity = 140/554 (25.27%), Postives = 243/554 (43.86%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPET-----------------------------PEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I + L++ + + R LGKG F +C+EI D +E + ++V ++ P +KE + EIAIH+ + N ++V H D V +++E+C RSL + + ++ A +G+ YLH+ + ++HRD+K N+ LN+ + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ DIW+ G LY ++ G PFET + L++T Y + + +Y P+ + I+ +L DP RP + +LL +F+ P SI P + P+ E G + + + Q + S+R ++ ED + W+S+W + Y L++ S+G + +++ D + + + R + PS ++ I +LK F Y+ + +L + + + PR +L ++ WF +++ LSNG QI+ F DHTKL +
Sbjct: 17 DPKSAPLKEIPDVLVDPRTMKRYMRGRFLGKGGFAKCYEITDMDTKEVFAGKVVPKSMLLKP-----HQKEKMSTEIAIHKSLDNPHVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--FMRQTIQGVQYLHNNR-VIHRDLKLGNLFLNDDMDVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDIWSLGCILYTLLVGKPPFET----------SCLKET----YIRIKKNEYSVPRHINPVASALIRRMLHADPTLRPSVAELLTDEFFTSGYAPMRLPTSCLTVPPRFSIAPSSLDPALLRKPLSSLNKGTDSPIEKMGKMDQPQREDLQQRDGPEQPDTHLTDMLQQLAVVNAAKPSDRDFIRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLSDNSVGVLFNDSTRLIMCADGDSLQYIDRNSLESYLSVRSY----PSALSKK----ITLLKYFRNYMSEHLLKA-GANITPREGDELTRLP---YLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLIL 534
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk2b (polo-like kinase 2b (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-070720-17]) HSP 1 Score: 154.066 bits (388), Expect = 6.327e-39 Identity = 104/358 (29.05%), Postives = 173/358 (48.32%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVI-----DAINNLSERISYIPQKVEDIIWVSRWAMKTLFQFYYTLNNGSIGGN 1434
LGKG F +C+E+ + SS+++ A K IP ++E NREI +H+ + +K+IV + D ++ +++E C RSLA + L + L YLH + I+HRD+K N+ +++ + K+ DFGLA E + ICGTP+YL+PE+ + GH ++SD+WA G +Y M+ G PFET + +++ Y+ + +Y P S L +K+ I G+L ++P RP L D++ +F+ T+ PET C + F +S + F E I+ + ++ EDI + + KT T ++ GGN
Sbjct: 60 LGKGGFAKCYEM--TDLSSSKIY--AAKIIPHTRVSKPHQREKINREIELHRTLSHKHIVHFYHHFED--KDNIYILLEYCGRRSLAHILKARKV--LTEPEVRYYLKQTVSALKYLHDLE-ILHRDLKLGNLFVSDSMELKVGDFGLAAKLEPVSNRRKTICGTPNYLSPEVLNKQGHGWESDVWALGCIMYTMLLGKPPFETTNLKET--------------YRCIREARYTLPSSLSLPAKQLISGMLAQNPVDRPHLDDIIRHEFF-TQGFMPETLPVSCCLSAPDFHISSPAKSFFKKAAAALFGGKKDKAKYYENINRLAKEEEDIFKLRQDFRKTAISNQITTHSPEEGGN 393
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk2b (polo-like kinase 2b (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-070720-17]) HSP 1 Score: 154.066 bits (388), Expect = 6.327e-39 Identity = 104/358 (29.05%), Postives = 173/358 (48.32%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVI-----DAINNLSERISYIPQKVEDIIWVSRWAMKTLFQFYYTLNNGSIGGN 1434
LGKG F +C+E+ + SS+++ A K IP ++E NREI +H+ + +K+IV + D ++ +++E C RSLA + L + L YLH + I+HRD+K N+ +++ + K+ DFGLA E + ICGTP+YL+PE+ + GH ++SD+WA G +Y M+ G PFET + +++ Y+ + +Y P S L +K+ I G+L ++P RP L D++ +F+ T+ PET C + F +S + F E I+ + ++ EDI + + KT T ++ GGN
Sbjct: 60 LGKGGFAKCYEM--TDLSSSKIY--AAKIIPHTRVSKPHQREKINREIELHRTLSHKHIVHFYHHFED--KDNIYILLEYCGRRSLAHILKARKV--LTEPEVRYYLKQTVSALKYLHDLE-ILHRDLKLGNLFVSDSMELKVGDFGLAAKLEPVSNRRKTICGTPNYLSPEVLNKQGHGWESDVWALGCIMYTMLLGKPPFETTNLKET--------------YRCIREARYTLPSSLSLPAKQLISGMLAQNPVDRPHLDDIIRHEFF-TQGFMPETLPVSCCLSAPDFHISSPAKSFFKKAAAALFGGKKDKAKYYENINRLAKEEEDIFKLRQDFRKTAISNQITTHSPEEGGN 393
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Match: plk2a (polo-like kinase 2a (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-060810-71]) HSP 1 Score: 152.14 bits (383), Expect = 3.163e-38 Identity = 90/270 (33.33%), Postives = 142/270 (52.59%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY 1185
LGKG F +C+E + + S+ ++ A K IP ++E +REI +H+ + +K+IV+ + D ++ +++E C RSLA + L + I GL YLH EQ I+HRD+K N +NE + K+ DFGLA E + + ICGTP+YL+PE+ + GH +SD+WA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L K+P RP+L D+L DF+
Sbjct: 59 LGKGGFAKCYE--FTDLSTGKMY--AAKIIPHTRVSKPHQREKIDREIELHRALHHKHIVQFYHHFED--KDNIYILLEYCSRRSLAHILKARKV--LTEPEVRYYLKQIVSGLKYLH-EQEILHRDLKLGNFFINEFMELKVGDFGLAAKLEPLENRRRTICGTPNYLSPEVLNKQGHGCESDVWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYSTPSSLSPQAKHLISSMLAKNPVDRPQLCDILRHDFF 305
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk1 (polo like kinase 1 [Source:NCBI gene;Acc:407937]) HSP 1 Score: 160.999 bits (406), Expect = 2.047e-41 Identity = 155/564 (27.48%), Postives = 261/564 (46.28%), Query Frame = 1
Query: 310 TEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIY--DSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHC-DHSMGFQLSMESIVFISDQPVIDAINN-----LSERISYI-----------PQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFIVDKSAVL--FDGKSE--NYEIVSVEDW--CIQNTSYLDIMRTLV 1899
+ +K I L++ + + R LGKG F +C+EI E S E+ A K +P + +K+ EIAI + + ++++V H D + V +++ELC RSL + + ++ +P + I G YLH + ++HRD+K N+ LN+++ KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ DIW+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +L+ +P RP + DLL +F+ T I P C F ++ +I +P + AIN L E YI ++ ED I WVS+W + Y L + S+G + +++ D + + + + + R + I +LK F Y+ + +L + + + PR +L F+ WF ++I LSNG QI+ F DHTK+ + A + D K E Y++ ++++ C + S L RT+V
Sbjct: 46 SSVKEIPEILVDPRTRRRYLRGRFLGKGGFAKCYEITDLE--SREV--FAGKIVPKTMLLKPHQKDKMTMEIAIQRSLDHRHVVGFHGFFED--NDFVYVVLELCRRRSLLELHKRRKAV-TEPEARYYLKQTIL-GCQYLHSNR-VIHRDLKLGNLFLNDEMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVDIWSIGCIMYTLLVGKPPFET----------SCLKET----YMRIKKNEYSVPKHINPMATALIQKMLRSEPTSRPTIDDLLNDEFFTTGYIPSRLPTT--CLTVPPRFSIAPSTIDQSLRKP-LTAINKGQDSPLVENWEYIEASEYNSCCSFSEEAEDPASVPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYNDGDSLQYIERNNSESYLNVRSYPAALTKKIT--------LLKYFRNYMSEHLLKAG-ANITPREGDELARLP---FLRTWFRTRSAIILHLSNGTVQINFFQDHTKIILCPLMAAVSYIDEKREFHTYKLSLIQEFGCCKELASRLRYARTMV 571
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk2 (polo-like kinase 2 [Source:NCBI gene;Acc:100125189]) HSP 1 Score: 157.918 bits (398), Expect = 2.649e-40 Identity = 131/536 (24.44%), Postives = 241/536 (44.96%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIP--QKVEDIIWVSRWAMKTLFQFYY-TLNNGSIG-----------GNIQN---------------FKGIVVTLDKKETH---FQQEDQTINSCLSRKFE-ELTPS--NINYYCDL-----------------IIKMLKPF--YIPQPI-----LASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISF-HDHTKLFIVDKS 1797
+ LGKG F +C+E+ + ++N++ A K IP ++E ++EI +H+ + ++++V+ + D ++ +++E C RS+A + L + I GL YLH Q I+HRD+K N +NE + K+ DFGLA E +Q + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L ++P+ RP L ++ + DF+ T+ PE C + F LS + F + E+ Y+ K +I+ + L+ F++ L + ++G G ++N F + +D + +Q D T+ + L P ++YY +L + +LK F Y+ + + L S+ +PR +++ +W ++++ L ++G +Q++F HDHTK+ I +++
Sbjct: 67 KVLGKGGFAKCYEM--TDLTTNKIY--AAKIIPHSRVSKPHQREKIDKEIELHRTLNHRHVVQFYHYFED--KENIYILLEYCSRRSMAHILKTRKV--LTDPEVRYYLKQIVSGLKYLH-AQEILHRDLKLGNFFINENMELKVGDFGLAARLEPLEQRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYSLPSSLMTSAKHLIASMLSRNPEDRPNLDEITQHDFF-TQGFTPERLPPSCCHTAPDFHLSSPAKNFFK-KAAAALFGGKKEKSKYLDNHSKYSNILHIGYTVDVQLYMFFFLGLEDSTMGTVADTVARVLRGCLENMPDADAIPKEQIDTSFHWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMNLLPDKKTVHYYAELGPCSVFPATEAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDVCRPR-----------LYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIIANQN 566
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451]) HSP 1 Score: 155.606 bits (392), Expect = 1.572e-39 Identity = 143/524 (27.29%), Postives = 240/524 (45.80%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY------------------------PTKSIYPETPED--------------EHCDHSMGFQL-SMESIVFISDQPVID-AINNLSERISYIP--------QKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSN--IFVYKWFFYCESVIFLLSNGCWQISFH-DHTKLFI 1785
R LGKG F +C+E+ E ++N+ A+K IP ++E EI +H+++ +K++VK D S ++ + +E+C +SLA ++ L+P + I GL YLH +GI+HRD+K N +NE + K+ DFGLA E +Q K ICGTP+YLAPE+ + GH +SDIW+ G +Y ++ G PFET + L++T Y+ + + KY P +K + GIL++ P +R L +LE +F+ P KS++ + + M + + S E V S VI+ A+ L + +S +P K E +WVS+W + F Y L+N SIG + +V+ ++ H+ N SR F + P++ + ++ I Q + L +L + + S + + +W +++ L SNG Q++F+ DHTK+ +
Sbjct: 64 RLLGKGGFARCYEMT--EVATNK--TYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFED--SENIYIFLEICSRKSLAHIWKARHTL-LEPE-VRYFLKQIISGLKYLH-LKGILHRDLKLGNFFINESMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFET----------SDLKET----YRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFTKGYTPDKLPPSSCVMVPDLHPPNPAKSLFTKVAKSLFGKTKSKSMYLLLSLFFFFMYYHVDSFEDCVTASG--VIETALAVLKDSLSSMPAEGNPTSLAKPEHFVWVSKWVDYSNKYGFGYQLSNRSIGVLFNSGTHMVLPAHRRHVHY-------NLTNSRHF--VFPTSA-----VPEQLQGQMSILQYFATYMEKNLMKGGDLPCHEEGSQTPLLLLQWVKTEHALLMLFSNGTLQVNFYNDHTKIIL 548
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk3 (polo-like kinase 3 [Source:NCBI gene;Acc:448451]) HSP 1 Score: 155.221 bits (391), Expect = 1.856e-39 Identity = 140/524 (26.72%), Postives = 236/524 (45.04%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY------------------------PTKSIYPE---------------------TPEDEHCDHSMGFQLSME---SIVFISDQPVIDAINNLSERISYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSN--IFVYKWFFYCESVIFLLSNGCWQISFH-DHTKLFI 1785
R LGKG F +C+E+ E ++N+ A+K IP ++E EI +H+++ +K++VK D S ++ + +E+C +SLA ++ L+P + I GL YLH +GI+HRD+K N +NE + K+ DFGLA E +Q K ICGTP+YLAPE+ + GH +SDIW+ G +Y ++ G PFET +++ Y+ + + KY P +K + GIL++ P +R L +LE +F+ P KS++ + +P D + + G +S S+V SD D+ N + K E +WVS+W + F Y L+N SIG + +V+ ++ H+ N SR F + P++ + ++ I Q + L +L + + S + + +W +++ L SNG Q++F+ DHTK+ +
Sbjct: 72 RLLGKGGFARCYEMT--EVATNK--TYAVKVIPHSRVAKPHQREKIVNEIDLHRELHHKHVVKFSHHFED--SENIYIFLEICSRKSLAHIWKARHTL-LEP-EVRYFLKQIISGLKYLH-LKGILHRDLKLGNFFINESMELKVGDFGLAARLEPPEQRKKTICGTPNYLAPEVLYRQGHGPESDIWSLGCVMYTLLCGTPPFETSDLKET--------------YRCIKQVKYTLPACLSSAAKHLLMGILKRTPGERLTLDQILEHEFFTKGYTPDKLPPSSCVMVPDLHPPNPAKSLFTKVAKSLFGKTKSKSIHAVSANSSPVDTLTEEASGKSVSRSIRGSLVSSSDA-FEDSEGNPTSL-----AKPEHFVWVSKWVDYSNKYGFGYQLSNRSIGVLFNSGTHMVLPAHRRHVHY-------NLTNSRHF--VFPTSA-----VPEQLQGQMSILQYFATYMEKNLMKGGDLPCHEEGSQTPLLLLQWVKTEHALLMLFSNGTLQVNFYNDHTKIIL 552
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Match: plk2 (polo-like kinase 2 [Source:NCBI gene;Acc:100125189]) HSP 1 Score: 154.836 bits (390), Expect = 4.122e-39 Identity = 91/296 (30.74%), Postives = 153/296 (51.69%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLS 1257
+ LGKG F +C+E+ + ++N++ A K IP ++E ++EI +H+ + ++++V+ + D ++ +++E C RS+A + L + I GL YLH Q I+HRD+K N +NE + K+ DFGLA E +Q + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L ++P+ RP L ++ + DF+ T+ PE C + F LS
Sbjct: 67 KVLGKGGFAKCYEM--TDLTTNKIY--AAKIIPHSRVSKPHQREKIDKEIELHRTLNHRHVVQFYHYFED--KENIYILLEYCSRRSMAHILKTRKV--LTDPEVRYYLKQIVSGLKYLH-AQEILHRDLKLGNFFINENMELKVGDFGLAARLEPLEQRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYSLPSSLMTSAKHLIASMLSRNPEDRPNLDEITQHDFF-TQGFTPERLPPSCCHTAPDFHLS 338
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk1 (polo like kinase 1 [Source:MGI Symbol;Acc:MGI:97621]) HSP 1 Score: 168.703 bits (426), Expect = 3.046e-44 Identity = 148/545 (27.16%), Postives = 245/545 (44.95%), Query Frame = 1
Query: 319 KSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPET--PEDEHCDHSM--GFQLSMESIVFISDQPVIDAINNL--------------------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQ-----TINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
K I L++ + + V R LGKG F +CFEI D +E + ++V +L P +KE + EI+IH+ + ++++V H D S V +++ELC RSL + + ++ A I G YLH Q ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ P SI P + P + G + + ++PV+ N SER ++ ED I WVS+W + Y L + S+G + +++ D + + D T++S + +++T +NY+ + Y+ + +L + + + PR +L ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 38 KEIPEVLVDPRSRRQYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQKEKMSMEISIHRSLAHQHVVGFHDFFED--SDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNQ-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSSRKPLKVLNKGVENPLPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKIT--LLNYFRN---------YMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGTVQINFFQDHTKLIL 543
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk2 (polo like kinase 2 [Source:MGI Symbol;Acc:MGI:1099790]) HSP 1 Score: 151.754 bits (382), Expect = 5.146e-38 Identity = 94/313 (30.03%), Postives = 153/313 (48.88%), Query Frame = 1
Query: 325 ISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLS 1257
IS +++ + + LGKG F +C+E+ N+ A K IP ++E ++EI +H+ + +K++V+ + D ++ +++E C RS+A + L + I GL YLH EQ I+HRD+K N +NE + K+ DFGLA E + + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K I +L K+P+ RP L D++ DF+ + P+ C F LS
Sbjct: 66 ISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNK----VYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFED--KENIYILLEYCSRRSMAHILKARKV--LTEPEVRYYLRQIVSGLKYLH-EQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFF-LQGFTPDRLSSSCCHTVPDFHLS 354
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk5 (polo like kinase 5 [Source:MGI Symbol;Acc:MGI:3026984]) HSP 1 Score: 146.362 bits (368), Expect = 1.378e-36 Identity = 93/285 (32.63%), Postives = 141/285 (49.47%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIP-GGIYDSK-KELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHC 1230
+GKGAF +C+++ S+ ALK +P GG + + REIA+H ++ ++ IV H D V M++E C +SLA + + L + G+ GL YLH +Q IVHRD+KP+N LN+ + KI D GLA + +CGTP++ APE+ + GHS +SDIWA G +Y ++ G PF ++ +YQN+ G Y P ++ I +L DP +RP L LL+ DF+ ++ PE C
Sbjct: 33 IGKGAFSRCYKLTDMSTSA----VFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFAD--RDHVYMVLEYCSRQSLAHVLKVRRT--LTEPEVRYYLRGLVSGLRYLH-QQRIVHRDLKPSNFFLNKNMEVKIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGTPPFAA--------------APLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFF-SQGFTPERLPPHSC 293
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk3 (polo like kinase 3 [Source:MGI Symbol;Acc:MGI:109604]) HSP 1 Score: 142.51 bits (358), Expect = 2.791e-35 Identity = 86/280 (30.71%), Postives = 146/280 (52.14%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPE 1209
R LGKG F +C+E E+ + A+K IP ++E EI +H+ + +++IV+ D + ++ + +ELC +SLA ++ L+P + I GL YLH ++GI+HRD+K N + + + K+ DFGLA E +Q K ICGTP+Y+APE+ + GH ++D+W+ G +Y ++ G PFET +++ Y+ + + Y P S L +++ + IL+ P+ RP + +L DF+ TK P+
Sbjct: 46 RLLGKGGFARCYEATDTESG----IAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTL-LEP-EVRYYLRQILSGLKYLH-QRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKET--------------YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFF-TKGYTPD 301
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Match: Plk3 (polo like kinase 3 [Source:MGI Symbol;Acc:MGI:109604]) HSP 1 Score: 142.895 bits (359), Expect = 3.134e-35 Identity = 86/280 (30.71%), Postives = 146/280 (52.14%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG--IYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPE 1209
R LGKG F +C+E E+ + A+K IP ++E EI +H+ + +++IV+ D + ++ + +ELC +SLA ++ L+P + I GL YLH ++GI+HRD+K N + + + K+ DFGLA E +Q K ICGTP+Y+APE+ + GH ++D+W+ G +Y ++ G PFET +++ Y+ + + Y P S L +++ + IL+ P+ RP + +L DF+ TK P+
Sbjct: 67 RLLGKGGFARCYEATDTESG----IAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFED--ADNIYIFLELCSRKSLAHIWKARHTL-LEP-EVRYYLRQILSGLKYLH-QRGILHRDLKLGNFFITDNMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKET--------------YRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFF-TKGYTPD 322
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q07832|PLK1_MOUSE (Serine/threonine-protein kinase PLK1 OS=Mus musculus OX=10090 GN=Plk1 PE=1 SV=2) HSP 1 Score: 168.703 bits (426), Expect = 2.131e-43 Identity = 148/545 (27.16%), Postives = 245/545 (44.95%), Query Frame = 1
Query: 319 KSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPET--PEDEHCDHSM--GFQLSMESIVFISDQPVIDAINNL--------------------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQ-----TINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
K I L++ + + V R LGKG F +CFEI D +E + ++V +L P +KE + EI+IH+ + ++++V H D S V +++ELC RSL + + ++ A I G YLH Q ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ P SI P + P + G + + ++PV+ N SER ++ ED I WVS+W + Y L + S+G + +++ D + + D T++S + +++T +NY+ + Y+ + +L + + + PR +L ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 38 KEIPEVLVDPRSRRQYVRGRFLGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQKEKMSMEISIHRSLAHQHVVGFHDFFED--SDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNQ-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSSRKPLKVLNKGVENPLPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKIT--LLNYFRN---------YMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGTVQINFFQDHTKLIL 543
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q62673|PLK1_RAT (Serine/threonine-protein kinase PLK1 OS=Rattus norvegicus OX=10116 GN=Plk1 PE=2 SV=2) HSP 1 Score: 167.933 bits (424), Expect = 4.024e-43 Identity = 147/545 (26.97%), Postives = 245/545 (44.95%), Query Frame = 1
Query: 319 KSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDH----SMGFQLSMESIVFISDQPVIDAINNL--------------------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQ-----TINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
K I L++ + + V R LGKG F +CFEI D +E ++V +L P +KE + EI+IH+ + ++++V H D S V +++ELC RSL + + ++ A I G YLH Q ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ P SI P + + + + G + + ++PV+ N SER ++ ED I WVS+W + Y L + S+G + +++ D + + D T++S + +++T +NY+ + Y+ + +L + + + PR +L ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 38 KEIPEVLMDPRSRRQYVRGRFLGKGGFAKCFEISDSDTKEVFPGKIVPKSLLLKP-----HQKEKMSMEISIHRSLAHQHVVGFHGFFED--SDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNQ-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYEGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGVENPLPDRPREKEEPVVRETNEAIECHLSDLLQQLTSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKIT--LLNYFRN---------YMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGTVQINFFQDHTKLIL 543
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q2TA25|PLK1_BOVIN (Serine/threonine-protein kinase PLK1 OS=Bos taurus OX=9913 GN=PLK1 PE=2 SV=2) HSP 1 Score: 166.392 bits (420), Expect = 1.361e-42 Identity = 145/521 (27.83%), Postives = 237/521 (45.49%), Query Frame = 1
Query: 382 LGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDHSMGFQLSMES------------IVFISDQPVIDAINNL------------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
LGKG F +CFEI D +E + ++V +L P +KE + EI+IH+ + ++++V H D + V +++ELC RSL + + ++ A I G YLH + ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + +Y PK + IK +LQ DP RP + +LL +F+ P SI P + + + ME+ +V + +PV ++++ SER ++ ED I WVS+W + Y L + S+G + +++ D + + D + + LT S+ I +LK F Y+ + +L + + + PR +L ++ WF ++I LSNGC QI+ F DHTKL +
Sbjct: 57 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQKEKMSMEISIHRSLAHQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHGNR-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKNNEYSIPKHINPVASSLIKKMLQPDPTARPTIHELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGMENPMPERPREKEEPVVREASEPVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYSDGDSLQYIERDGSESY--------LTVSSHPNSLIKKITLLKYFRNYMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGCVQINFFQDHTKLIL 541
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|P53350|PLK1_HUMAN (Serine/threonine-protein kinase PLK1 OS=Homo sapiens OX=9606 GN=PLK1 PE=1 SV=1) HSP 1 Score: 162.155 bits (409), Expect = 5.241e-41 Identity = 143/521 (27.45%), Postives = 236/521 (45.30%), Query Frame = 1
Query: 382 LGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDH----SMGFQLSMESIVFISDQPVI------------DAINNL--------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
LGKG F +CFEI D +E + ++V +L P ++E + EI+IH+ + ++++V H D + V +++ELC RSL + + ++ A I G YLH + ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ P SI P + + + + G + + ++PV+ D + L SER ++ ED I WVS+W + Y L + S+G + +++ D + + D T + LT S+ I +LK F Y+ + +L + + + PR +L ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQREKMSMEISIHRSLAHQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNR-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELLNDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEEPVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESY--------LTVSSHPNSLMKKITLLKYFRNYMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGSVQINFFQDHTKLIL 543
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Match: sp|Q8SWM6|CDC5_ENCCU (Probable cell cycle serine/threonine-protein kinase CDC5 homolog OS=Encephalitozoon cuniculi (strain GB-M1) OX=284813 GN=CDC5 PE=3 SV=2) HSP 1 Score: 152.91 bits (385), Expect = 1.037e-38 Identity = 98/286 (34.27%), Postives = 152/286 (53.15%), Query Frame = 1
Query: 355 YNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKK--ELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIF--QQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKR--FIKGILQKDPQKRPRLIDLLEQDFYPTK 1194
+ K +LK+ LG+GA+ QC+ E S E Q A+K + S+K E EIAIH K+ N +VK+++ S V M++ELC +L + +NG LK H+ R GL+YLH+ +VHRD+K N+ L+ K + KI DFGL+ + ++ K +CGTP+Y+APE+ + GHSF++DIW+ GV +Y ++ G PF+ ++ D +Y+ + Y FP++ L S+ I IL +P +RP L +L F K
Sbjct: 21 HTKYMLKKLLGRGAYAQCY---LAEIESGE--QYAMKVVRLKDIKSRKVHEKLESEIAIHSKLDNPNVVKMYRSFRS--SEYVFMVLELCERGALDALLKRNGK--LKERHVARFVKQTVEGLIYLHNSVSVVHRDLKLGNLFLDSKFNVKIGDFGLSAVIKDGEK-KVTMCGTPNYIAPEVLFGKASGHSFEADIWSLGVIIYTLLVGVPPFQKKNVED--------------IYKMIKLNNYIFPENCDLSSEAIDLITQILNTNPLERPTLEHILSHKFLSKK 282
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: A0A4X1UWP2 (Serine/threonine-protein kinase PLK OS=Sus scrofa OX=9823 PE=3 SV=1) HSP 1 Score: 177.948 bits (450), Expect = 1.847e-44 Identity = 153/524 (29.20%), Postives = 250/524 (47.71%), Query Frame = 1
Query: 382 LGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHC-DHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFIVDKSAVL--FDGKSE--NYEIVSVEDW-CIQN-TSYLDIMRTLVYSIL 1911
LGKG F +CFEI D +E + ++V +L P +KE + EI+IH+ + ++++V H D + V +++ELC RSL + + ++ A I G YLH + ++HRD+K N+ LNE + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G +Y ++ G PFET + L++T Y + + +Y PK + I+ +LQ DP RP + +LL +F+ + I P C F ++ S+ S +P+ +E + IP I WVS+W + Y L + S+G + +++ D + + D T + LT S+ I +LK F Y+ + +L + + + PR +L ++ WF ++I LSNGC QI+ F DHTKL + A + D K + Y + +E++ C + S L RT+V +L
Sbjct: 59 LGKGGFAKCFEISDADTKEVFAGKIVPKSLLLKP-----HQKEKMSMEISIHRSLAHQHVVGFHGFFED--NDFVFVVLELCRRRSLLELHKRRKALTEPEARY--YLRQIVLGCQYLHRNR-VIHRDLKLGNLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCIMYTLLVGKPPFET----------SCLKET----YLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTIHELLNDEFFTSGYIPARLPIT--CLTIPPRFSIAPSSLDPSSRKPLTVLNKEEAEDPACIP-----IFWVSKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESY--------LTVSSHPNSLIKKITLLKYFRNYMSEHLLKA-GANITPREGDELARLP---YLRTWFRTRSAIILHLSNGCVQINFFQDHTKLILCPLMAAVTYIDEKRDFRTYRLSLLEEFGCSKELASRLRYARTMVDKLL 539
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: A0A0R3PF71 (Serine/threonine-protein kinase PLK OS=Angiostrongylus costaricensis OX=334426 GN=ACOC_LOCUS2798 PE=3 SV=1) HSP 1 Score: 176.792 bits (447), Expect = 2.501e-44 Identity = 147/556 (26.44%), Postives = 263/556 (47.30%), Query Frame = 1
Query: 301 MKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----PTK-SIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERIS-----YIPQKVED-------IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLI---IKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFIVD-KSAVLFDGKSENYEIVSVEDW----CIQNTSYL 1878
M+ +K + +++++ + + + LGKG F +C+E+ +++NE+ + + ++E +E+ IH+ + + ++V+L+ D + +V + +ELC RSL + + S+ A + +C + YLH E+ ++HRD+K N+ LN + KI DFGLATT + + K +CGTP+Y+APE+ + GHSF+ DIWA G LY ++ G PFET+ SL++T Y + +Y+ P +A I+ +L DP KRP + +L DF+ PT+ I T + HS+G I+ P ++ L E+IS +P VED I W+S+W + Y L + S+G + +V+ E + ++++T N I Y D + + +LK F Y+ + ++ + + K + ++ + Y WF +++ LSNG QI+ F DHTK + AV + + N+ + + C + T++L
Sbjct: 1 MEKAPLKEVPERIVDTEHGVTYIRGKFLGKGGFARCYEL--TNSATNEVFAGKIVSKTLLVKQYQREKMTQEVHIHRSLSHPHVVQLYNFFED--NDNVYITLELCARRSLMELHKRRRSVTEPEARY--FTHQVCLAVEYLH-EKNVIHRDLKLGNLFLNGDLQVKIGDFGLATTVDMDGERKKTLCGTPNYIAPEVLDKKGHSFEVDIWAIGCILYTLLFGRPPFETK----------SLKET----YSRIKMNQYRLPSTAGQTVTHLIQNLLAPDPAKRPTVKQVLAHDFFRSGFMPTRLPISCLTMAPKFNRHSVG----------IAKVPEDGFLSELYEQISSLCNARVPD-VEDEAPEAMPIFWISKWVDYSDKYGIGYQLCDNSVGVLFNDSSKLVLDEAGSELTYIEKNETENY-----------YGIESYPDFLSKKVTLLKYFRSYMNEHLIKAGANVAKKDGD---DLARLPVLRY-WFRTRSAIVLHLSNGTLQINFFEDHTKTIVCPLMGAVTYIDEQRNFRVYKLSHLESHGCTKVTNFL 509
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: X1XTV5 (Serine/threonine-protein kinase PLK OS=Acyrthosiphon pisum OX=7029 GN=100168105 PE=3 SV=1) HSP 1 Score: 177.563 bits (449), Expect = 3.666e-44 Identity = 158/572 (27.62%), Postives = 244/572 (42.66%), Query Frame = 1
Query: 313 EIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELF--------NREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY------------------------------------------PTKSIYPETPEDEHCDHSMGFQLSMESIV---------------------FISDQPVIDAINNLSERISYIPQKVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQE---------DQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFI 1785
E+K I + ++++ N+ K LGKG F +C+EI + M K + G SKK L +EI IH+ + NK IV H D V +++ELC RS+ + + + L I +G +YLH +Q I+HRD+K N+ LN+++ KI D GLA E Q K +CGTP+Y+APEI + GHSF+ D+W+ G +Y ++ G PFET NSL++T Y + R Y P ++ I+ +LQ DP+KRP + ++L+ DF+ P + P+D H M + S S+ ++ +P +NN+ E + Q +I VS+W + F Y L++ S+G +F IV+ + K+ H+ ++ DQT L +K + L Y D + K K +LA L P ++Y+WF SVI LSNG QI+F DHTK+ +
Sbjct: 8 EVK-IPDVIIDTKNHKKYKKCSFLGKGGFAKCYEI----------IDMKTKEVFAGKIVSKKYLLKHNQKDKMTQEIFIHKVLNNKNIVSFHSFFED--KDFVYIVLELCRKRSMMELHRRRKT--LTEPETRYYVQQILQGTLYLH-QQNIIHRDLKLGNLFLNDEMEVKIGDLGLAAKIEFVGQRKKTLCGTPNYIAPEILSKTGHSFEVDVWSIGCIMYTLLVGKPPFET----------NSLKET----YARITRCDYNIPSHLNKNARTLIEKMLQSDPKKRPLVSEILKADFFTIGYMPKKLPPSCLTTAPRFDSINYRESISNRRPLIELNSPKPAVNKSASKPQDPGLKHPMFTEPSRPSVRNSVSTIDCKEHMISLEKELENLLNLKPSKTRMNNMEETTDPVAQP---LICVSKWVDYSDKYGFGYELSDDSVGVMFNDFTRIVLLANLKDIHYIEKNGFEQYYTIDQT-PPALEKKIKLLMYFR-RYMDDHLNKAGK------DLLAKDADQLSRTP-----------YLYQWFRSTSSVIMQLSNGTLQINFTDHTKVIL 527
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: A0A3B3SSZ3 (Serine/threonine-protein kinase PLK OS=Paramormyrops kingsleyae OX=1676925 GN=PLK1 PE=3 SV=1) HSP 1 Score: 174.866 bits (442), Expect = 3.517e-43 Identity = 151/580 (26.03%), Postives = 258/580 (44.48%), Query Frame = 1
Query: 316 IKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDHSMGFQLSMESIV--------FISDQPVIDAINNL-----SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFIVDKSAVL--FDGKSE--NYEIVSVEDW--CIQNTSYLDIMRTLVYSIL 1911
+K I + L++ + + R LGKG F +C+EI D +E + ++V ++ P +KE + EI IH+ + N ++V H D V +++E+C RSL + + ++ A + +G YLH+ + ++HRD+K N+ L++ + KI DFGLAT E + K +CGTP+Y+APEI + GHSF+ DIW+ G LY ++ G PFET +D+ Y + + +Y P+ + IK +L DP RP + DLL +F+ P SI P + E +H S+ ++SD ++ + N SER ++ ED I W+S+W + Y L + S+G + +++ D + + + R + + I +LK F Y+ + +L + + + PR +L ++ WF +++ LSNG QI+ F DHTKL + A + D K E Y + +E + C + S + RT+V ++
Sbjct: 23 LKEIPDILVDPRTSKRYMRGRFLGKGGFAKCYEITDLDTKEVFAGKVVPKSMLLKP-----HQKEKMSMEITIHKSLENPHVVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--YMRQMIQGCQYLHNNR-VIHRDLKLGNLFLSDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEILCKKGHSFEVDIWSLGCILYTLLVGKPPFETSCLKDT--------------YLRIKKNEYMIPRHINPVAASLIKRMLNADPTLRPTIGDLLSDEFFTSGYIPLRLPTTCLTVPPRFSIAPSSLESDHRKPLTAINRGTTSMADESETADCYLSD--LLKQLANFNATKPSERAVIRQEEAEDPACVPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDSTRLIMYDDGDRLQYIDRNSEESYLRVRSYPSMLTKKIT--------LLKYFRNYMSEHLLKA-GANITPRDGDELARLP---YLRHWFRTKSAIVLHLSNGTVQINFFQDHTKLILCPLMAAVTYIDQKREFRTYRMAQIEQYGCCRELASRMRYARTMVEKLM 564
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Match: A0A1D2MF42 (Serine/threonine-protein kinase PLK OS=Orchesella cincta OX=48709 GN=Ocin01_15064 PE=3 SV=1) HSP 1 Score: 175.637 bits (444), Expect = 4.130e-43 Identity = 142/535 (26.54%), Postives = 232/535 (43.36%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSK--KELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKR-FIKGILQKDPQKRPRLI-----DLLEQDFYPT--------------KSIYPETPEDEHCDHSM---------------------GFQLSMESIVFISDQPVIDAINNLSERISYI---------PQKVED---------IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQI-SFHDHTKLFI 1785
R LGKG F +C+E+ N +A K + G+ + +E +EI IH+ + ++YIV H D +V +++ELC +SL + + +I A + ++YLH ++ I+HRD+K NI +N+ + KI DFGLAT + K +CGTP+Y+APE+ + GHSF+ DIW+ G LY ++ G PFET RD+ Y + RG Y P S S R I +LQ +P RP + L Q+F P ++ P P + + SME +S Q +++ I + +I P ++D ++W+S+W + F Y L++ SIG + + +++ D H+ + N + F P+ + +K+L F Y+ + +L S P NL + N ++ WF +V+ +LSNG QI +F DHTK+ +
Sbjct: 58 RFLGKGGFARCYEV----VDPNTKQTLACKIVNKGLLQKQHQREKMAQEITIHRDLKHEYIVDFHSYFED--DNNVYIVLELCAKKSLMELQKRRRAITESEARY--FLRQLTLAVLYLHEDKKIIHRDLKLGNIFINDNMELKIGDFGLATHISFDGERKKTLCGTPNYIAPEVLAKRGHSFEVDIWSMGCILYTLLFGKPPFETNSLRDT--------------YTKIRRGDYYIPASRIGNSTRNLITRMLQVEPSLRPTAKQILAHEFLTQNFIPNSLPVSCLTTAPRFDRTTRPAAPASSNTKRPLVEHNPRGSPIANRPKTTGKGGNMNTSMEQGYEMSSQDIMELIQTMKNQIVEALTGKGVRKPPTLIDDESEEPSLSPMLWISKWVDYSDKYGFGYQLSDDSIGVSFNDQTKLILLPDLNSMHYIERGGKENYYTTEVF----PTELQKK----VKLLNYFQQYMKENLLKSTGGKAPPNSNLIPRLPN----LWTWFRTSRAVVMILSNGTMQINNFRDHTKMIL 558
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk1 (polo like kinase 1 [Source:NCBI gene;Acc:103034005]) HSP 1 Score: 166.777 bits (421), Expect = 8.892e-44 Identity = 140/540 (25.93%), Postives = 241/540 (44.63%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPETPEDEHCDHSM-GFQLSMESIVFISDQP------VIDAINNL--------SERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I + L++ + + R LGKG F +C+EI + +E + ++V +L P +KE + EIAIH+ + N ++V H D V +++E+C RSL + + ++ A +G+ YLH+ + ++HRD+K N+ L++ + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G LY ++ G PFET + L++T Y + + +Y P+ + I+ +L DP RP + DLL +F+ P SI P + + + M + + D P + D + L SER ++ ED + W+S+W + Y L + S+G +F +++ D + + + R + I +LK F Y+ + +L + + + PR +L ++ WF +++ LSNG QI+ F DHTKL +
Sbjct: 16 DPKSAPLKEIPDILVDPRTMKRYMRGRFLGKGGFAKCYEITDMETKEVFAGKVVPKSLLMKP-----HQKEKMSTEIAIHKSLDNPHVVGFHGFFED--DDFVFVVLEICRRRSLLELHKRRKAVTEPEARY--FMRQTIQGVHYLHNNR-VIHRDLKLGNLFLSDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDVWSLGCILYTLLVGKPPFET----------SCLKET----YVRIKKNEYSIPRQINPVAASLIRRMLHADPTLRPSVADLLTDEFFTSGYVPLRLPTSCLTVPPRFSIAPSSLDPGLLRRPLTALNTGMLVLFILVDGPEQPDSHLTDMLQQLNSVNASRPSERDFVRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLCDNSVGVLFNDFTRLIMYEDGDSLQYIDRNAAESYLSVRSYPPALSKKIT--------LLKYFRNYMSEHLLKA-GANITPRDGDELTRLP---YLRHWFRTKSAIVLNLSNGTVQINFFQDHTKLIL 519
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk1 (polo like kinase 1 [Source:NCBI gene;Acc:103034005]) HSP 1 Score: 160.229 bits (404), Expect = 2.353e-41 Identity = 140/554 (25.27%), Postives = 243/554 (43.86%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY-----------------PTKSIYPET---------------------------PEDEHCDHSMGFQLSMESIVFISDQPVIDAIN--NLSERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I + L++ + + R LGKG F +C+EI + +E + ++V +L P +KE + EIAIH+ + N ++V H D V +++E+C RSL + + ++ A +G+ YLH+ + ++HRD+K N+ L++ + KI DFGLAT E + K +CGTP+Y+APE+ + GHSF+ D+W+ G LY ++ G PFET + L++T Y + + +Y P+ + I+ +L DP RP + DLL +F+ P SI P + P+ E G + + + Q ++++N SER ++ ED + W+S+W + Y L + S+G +F +++ D + + + R + I +LK F Y+ + +L + + + PR +L ++ WF +++ LSNG QI+ F DHTKL +
Sbjct: 16 DPKSAPLKEIPDILVDPRTMKRYMRGRFLGKGGFAKCYEITDMETKEVFAGKVVPKSLLMKP-----HQKEKMSTEIAIHKSLDNPHVVGFHGFFED--DDFVFVVLEICRRRSLLELHKRRKAVTEPEARY--FMRQTIQGVHYLHNNR-VIHRDLKLGNLFLSDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSFEVDVWSLGCILYTLLVGKPPFET----------SCLKET----YVRIKKNEYSIPRQINPVAASLIRRMLHADPTLRPSVADLLTDEFFTSGYVPLRLPTSCLTVPPRFSIAPSSLDPGLLRRPLTALNTDSPIEKMGKGDQPQKEELQQRDGPEQPDSHLTDMLQQ--LNSVNASRPSERDFVRQEEAEDPACIPVFWISKWVDYSDKYGLGYQLCDNSVGVLFNDFTRLIMYEDGDSLQYIDRNAAESYLSVRSYPPALSKKIT--------LLKYFRNYMSEHLLKA-GANITPRDGDELTRLP---YLRHWFRTKSAIVLNLSNGTVQINFFQDHTKLIL 531
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk2b (serine/threonine-protein kinase PLK2 [Source:NCBI gene;Acc:103027010]) HSP 1 Score: 154.836 bits (390), Expect = 3.336e-39 Identity = 92/300 (30.67%), Postives = 153/300 (51.00%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVF 1275
LGKG F +C+E+ + S+ ++ A K IP ++E NREI +H+ + +K+IV + D ++ +++E C RSLA + L + L YLH +Q I+HRD+K N+ +++ + K+ DFGLA E + ICGTP+YL+PE+ + GH ++SDIWA G +Y M+ G PFET + R++ Y+ + +Y P + L +++ I +L ++P RPRL +++ +F T+ PET C + F +S + F
Sbjct: 61 LGKGGFAKCYEL--TDLSAGKVY--AAKIIPHSRVAKPHQREKINREIELHRALSHKHIVHFYHSFED--KDNIYILLEYCSRRSLAHILKARKV--LTEPEVRYYLRQTVSALKYLH-DQEILHRDLKLGNLFVSDSMELKVGDFGLAAKLEPVSNRRKTICGTPNYLSPEVLNKQGHGWESDIWALGCVMYTMLLGKPPFETTNLRET--------------YRCIREARYSLPSTISLSARQLIASMLSRNPTDRPRLDEIIRHEFL-TQGFMPETLPASCCLSAPDFHISSPAKSF 336
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk2a (serine/threonine-protein kinase PLK2 [Source:NCBI gene;Acc:103036971]) HSP 1 Score: 151.754 bits (382), Expect = 2.806e-38 Identity = 91/270 (33.70%), Postives = 142/270 (52.59%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY 1185
LGKG F +C+E + + SS ++ A+K IP ++E +REI +H+ + +K+IV+ + D ++ +++E C RSLA + L + I GL YLH EQ I+HRD+K N +NE + KI DFGLA E + + ICGTP+YL+PE+ + GH +SD+WA G +Y M+ G PFET + +++ Y+ + +Y P + +K I +L K P+ R RL D+L DF+
Sbjct: 59 LGKGGFAKCYE--FTDLSSGKVY--AVKIIPHTRVSKPHQREKIDREIELHRTLHHKHIVQFYHHFED--KENIYILLEYCSRRSLAHILKARKV--LTEPEVRYYLRQIVTGLKYLH-EQEILHRDLKLGNFFINEGMELKIGDFGLAAKLEPVENRRRTICGTPNYLSPEVLNKQGHGCESDVWALGCVMYTMLLGRPPFETTNLKET--------------YRCIREARYSMPSTLSPQAKHLISNMLAKSPEDRLRLDDVLRHDFF 305
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Match: plk3 (polo like kinase 3 [Source:NCBI gene;Acc:103024965]) HSP 1 Score: 141.354 bits (355), Expect = 8.284e-35 Identity = 87/285 (30.53%), Postives = 142/285 (49.82%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHC 1230
LGKG F +C+E+ +S A+K IP ++E EI +H+ + +K++VK D ++ + +ELC +SLA + L + I GL YLH+ +GI+HRD+K N +NE + ++ DFGLA E +Q K ICGTP+YLAPE+ + GH +SD+W+ G +Y ++ G PFET +++ Y+ + +Y P S +++ I +LQK+P R L +L +++ +K P+ C
Sbjct: 71 LGKGGFARCYEMTDLASSR----MYAVKVIPQSRVSKPHQREKITNEIELHKTLQHKHVVKFSHHFED--QDNIYIFLELCSRKSLAHIWKARHT--LTDPEVRYYLRQIISGLKYLHN-KGILHRDLKLGNFFVNENMELRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLGCVMYTLLCGNPPFETLDLKET--------------YKCIKEVRYSLPPSLSPAAQKLISAVLQKNPSDRLTLDQILVHEYF-SKGFTPDKLPPSSC 331
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: plk3 (polo-like kinase 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-030131-6134]) HSP 1 Score: 132.88 bits (333), Expect = 9.490e-33 Identity = 86/281 (30.60%), Postives = 135/281 (48.04%), Query Frame = 1
Query: 376 RSLGKGAFGQCFEIDWQENSSNELVQMALK---FIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDL-----LEQDFYPTK 1194
R LGKG F +C+ + + + ++ K PG + +EI++H+K+ +++IV+ D + +I+ELC +SLA + L + + GL YLH + G+VHRD+K N + + + KI D GLATT E + K +CGTP+YLAPE+ + GH ++DIW+ G ++ M+AG PF T D N Y + G++ FP S ++ + L DP R L+DL L Q F P +
Sbjct: 31 RLLGKGGFARCYLVTEEYTGCHFAAKIITKQRVEKPG-----HRAKIEQEISLHRKLHHRHIVQFISSFKD--ENFIYIILELCNGQSLAHMLRSRKV--LTETEVKYYLRQLISGLRYLH-QCGVVHRDLKLGNFFVTDSMEVKIGDLGLATTLEPPEMRKRTVCGTPNYLAPEVLNKRGHGPEADIWSLGCAVFTMLAGRPPFSTS---DLAN-----------TYACIRSGRFNFPPSLSHAARDLLTSALTPDPDLRASLLDLQSHPFLTQGFVPDR 287
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002824.1 (pep scaffold:Pmarinus_7.0:GL476598:1893846:1903215:-1 gene:ENSPMAG00000002574.1 transcript:ENSPMAT00000002824.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 110.153 bits (274), Expect = 7.321e-27 Identity = 73/273 (26.74%), Postives = 139/273 (50.92%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIP------GGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
LGKG+F C ++ S + +++A+K I G+ D + E+ IH ++ + I++++ D V +++E+C+N ++ ++ G + + I GL+YLH G++HRD+ AN+LL +S +I+DFGLA +++ +CGTP+Y++PE+ + H +D WA G Y M+ G PF+ ++++ T+ V +++ P + ++ ++ +L++DP KRP L +LE F
Sbjct: 19 LGKGSFA-CV---YRARSCHTGIEVAIKMIDKQAMRRAGMVDRVRA----EVEIHSQLKHPAILEMYGCFED--DNYVYLVLEMCHNGEMSRYLKNQGRPFTEEQEARQFLREISSGLLYLH-AHGVIHRDLTLANLLLASDMSTRIADFGLAARLPLPGESRLTVCGTPNYMSPEVASRGPHGTPADAWALGCAAYAMLVGRPPFQ----------ASAVPATLARVL-----ARFELPPTLSPAARDLLRRLLRRDPGKRPGLPAVLEHPF 265
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010749.1 (pep scaffold:Pmarinus_7.0:GL476742:232416:246048:1 gene:ENSPMAG00000009735.1 transcript:ENSPMAT00000010749.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 108.612 bits (270), Expect = 7.876e-25 Identity = 64/226 (28.32%), Postives = 113/226 (50.00%), Query Frame = 1
Query: 505 FNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
F E+ IH ++ + +++L+ D V +++E+C N + ++ G+ + G++YLH GI+HRD+ +N+LL ++ KI+DFGLA ++ +CGTP+Y++PEI + H +SD+W+ G LY M+ G PF+T ++N+ V+ G+Y P ++ I +LQK+P R L +L+ F
Sbjct: 13 FRNEVEIHCQLKHPSVLELYTCFED--QNYVYLVLEMCNNGEVGRYLKAKGTP-FSEEQVRHFMKQTVHGMLYLH-SHGILHRDLTLSNLLLTADMNIKIADFGLAAQLRLPEEKHFTMCGTPNYISPEIATRGAHGLESDVWSLGCMLYTMLVGRPPFDTDAIGTTLNR--------------VVLGEYSEPMHLSKPARSLIHQLLQKNPVDRLGLACVLDHPF 220
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: stk33 (serine/threonine kinase 33 [Source:ZFIN;Acc:ZDB-GENE-040724-242]) HSP 1 Score: 103.99 bits (258), Expect = 9.977e-25 Identity = 78/281 (27.76%), Postives = 124/281 (44.13%), Query Frame = 1
Query: 370 LKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLN--------EKISPKISDFGLATTPEQ--CQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSA----PLCSKRFIKGILQKDPQKRPRLIDLL 1170
L R LG G+FG +E E ++ K G S L RE+ I +++ ++ I+ L +V V ++MELC L + Q L A V + + + YLH + IVHRD+K NIL + + +++DFGL+ E CGTP Y+A E+ Q +S Q D+W+ GV LY ++ G PF Q +++ +I+G+ F + A +K ++G+L+ DP R +LL
Sbjct: 7 LGRQLGSGSFGTVYEATHVETGVKWAIKTVNKERAG---SSGVRLLEREVVILKRVQHQNIIHLEEVL--ETHKRVYLVMELCELGELRAVLEQRKR--LSEAEARHVAHSLAGAIAYLH-KHDIVHRDLKLENILAKSSEPHEGIDHLDIRVTDFGLSAVREGNGAASMLQSPCGTPIYMAAEVIQSQDYSQQCDVWSIGVILYMLLCGEPPFMAHSQEK--------------LFELIIKGELSFTQPAWEEVSESAKELLRGLLKVDPAHRLTASELL 265
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010747.1 (pep scaffold:Pmarinus_7.0:GL476742:232416:246048:1 gene:ENSPMAG00000009735.1 transcript:ENSPMAT00000010747.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 108.227 bits (269), Expect = 9.982e-25 Identity = 64/226 (28.32%), Postives = 113/226 (50.00%), Query Frame = 1
Query: 505 FNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
F E+ IH ++ + +++L+ D V +++E+C N + ++ G+ + G++YLH GI+HRD+ +N+LL ++ KI+DFGLA ++ +CGTP+Y++PEI + H +SD+W+ G LY M+ G PF+T ++N+ V+ G+Y P ++ I +LQK+P R L +L+ F
Sbjct: 13 FRNEVEIHCQLKHPSVLELYTCFED--QNYVYLVLEMCNNGEVGRYLKAKGTP-FSEEQVRHFMKQTVHGMLYLH-SHGILHRDLTLSNLLLTADMNIKIADFGLAAQLRLPEEKHFTMCGTPNYISPEIATRGAHGLESDVWSLGCMLYTMLVGRPPFDTDAIGTTLNR--------------VVLGEYSEPMHLSKPARSLIHQLLQKNPVDRLGLACVLDHPF 220
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603]) HSP 1 Score: 130.183 bits (326), Expect = 6.709e-32 Identity = 87/273 (31.87%), Postives = 140/273 (51.28%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS---KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGD--VQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIF--QQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLC--SKRFIKGILQKDPQKRPRLIDLLE 1173
LG+G F +CF+I ++ S E+ A K + S +K+L + EI IH+ M + IV+ ID D V +++E+C N SL + + + L + IC + Y+H + ++HRD+K NI + + KI DFGLA + K+ ICGTP+Y+APE+ + GHSF+ DIW+ GV LY ++ G PF+ RD + +Y+ + + FP+ P+ K I+ IL DP +RP L ++++
Sbjct: 88 LGEGGFARCFQI---KDDSGEI--FAAKTVAKASIKSEKTRKKLLS-EIQIHKSMSHPNIVQF----IDCFEDDSNVYILLEICPNGSLMELLKRRKV--LTEPEVRFFTTQICGAIKYMHSRR-VIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPNYIAPEVLMGKHSGHSFEVDIWSLGVMLYALLIGKPPFQA---RD-----------VNTIYERIKCRDFSFPRDKPISDEGKILIRDILSLDPIERPSLTEIMD 333
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: MKK2 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p; MKK2 has a paralog, MKK1, that arose from the whole genome duplication [Source:SGD;Acc:S000006061]) HSP 1 Score: 101.679 bits (252), Expect = 3.851e-23 Identity = 79/263 (30.04%), Postives = 128/263 (48.67%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLA----DFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRP 1152
LG+GA G + + N ALK I D +K++F RE+ ++ + YIV+ + + D S + + ME +SL + + + G I + + ++ + RGL YLH E+ ++HRDIKP NILLNEK K+ DFG++ E GT Y+APE Q +S D+W+ G+TL + G PFE+ ++ L T+ L + ++ + + S + FI L+KD ++RP
Sbjct: 220 LGEGAGGSVAKCRLK----NGKKVFALKTINTMNTDPEYQKQIF-RELQFNKSFKSDYIVQYYGMFTDEQSSSIYIAMEYMGGKSLEATYKNLLKRGGRISERV--IGKIAESVLRGLSYLH-ERKVIHRDIKPQNILLNEKGEIKLCDFGVSG--EAVNSLAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVAGGRFPFESDKITQNVAPIELL--TMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERP 470
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931]) HSP 1 Score: 98.9821 bits (245), Expect = 2.204e-22 Identity = 75/269 (27.88%), Postives = 135/269 (50.19%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIF--QQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
+G+G FG ++ + + E+V A+K + D EL +EI ++ + I ++ +S + ++ME C S +D + ++ GL ++ + + + GL YLH EQ +HRDIK ANILLNE+ K+ DFG++ + + GTP+++APE+ + G++ ++DIW+ G+T Y ++ G P ++K + ++ L + + + F +A K F+ G L K P RP +LL +F
Sbjct: 24 IGRGNFGDVYKA--VDRVTQEIV--AIKVVNLEHSDEDIELLAQEIFFLAELKSPLITNYIATMLEDVS--MWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFIIHEVTLGLKYLH-EQRKIHRDIKAANILLNEEGMVKLGDFGVSGHIRSTLK-RDTFVGTPYWMAPEVVCCEVDGYNEKADIWSLGITTYELLKGLPP---------LSKYDPMKVMTNLPKRKPPKLQGPFSDAA----KDFVAGCLVKTPADRPSAYNLLSFEF 271
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: TOS3 (Protein kinase; related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome; TOS3 has a paralog, SAK1, that arose from the whole genome duplication [Source:SGD;Acc:S000003147]) HSP 1 Score: 97.0561 bits (240), Expect = 1.492e-21 Identity = 70/228 (30.70%), Postives = 112/228 (49.12%), Query Frame = 1
Query: 355 YNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQN-------GSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQC---------QQTKHKICGTPHYLAPEIF---QQYGHSFQSDIWAFGVTLYFMIAGYTPF 981
Y K+ L R LG GA ++ E S +Q+ ++ N+EI + ++ ++ +V+L+++ DP S V +++E C +R + +N G L +V + GL YLH QGI HRDIKP+N+L++ + KISDFG+A + Q K + GTP + APE+ ++Y S DIW+ GVT+Y ++ G PF
Sbjct: 61 YGKVKLARDLGTGALVAIKILNRFEKRSGYSLQLKVE----------NPRVNQEIEVMKRCHHENVVELYEILNDPESTKVYLVLEYC-SRGPVKWCPENKMEIKAVGPSILTFQQSRKVVLDVVSGLEYLH-SQGITHRDIKPSNLLISSNGTVKISDFGVAMSTATGSTNIQSSHEQLLKSRALGTPAFFAPELCSTEKEYSCSSAIDIWSLGVTIYCLLFGKLPF 276
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Match: MKK1 (MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication [Source:SGD;Acc:S000005757]) HSP 1 Score: 96.6709 bits (239), Expect = 1.713e-21 Identity = 80/266 (30.08%), Postives = 130/266 (48.87%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSL----ADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCS---KRFIKGILQKDPQKRP 1152
LG+GA G + + S ALK I D +K++F RE+ ++ ++YIV+ + + D + + + ME RSL + + + G I K + ++ + RGL YLH E+ ++HRDIKP NILLNE K+ DFG++ E GT Y+APE Q +S SD+W+ G+T+ + G P ++ +I L +T + ++ + P+S + S K FI L+KD ++RP
Sbjct: 227 LGEGAGGSVSKCKLKNGSK----IFALKVINTLNTDPEYQKQIF-RELQFNRSFQSEYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRISEK--VLGKIAEAVLRGLSYLH-EKKVIHRDIKPQNILLNENGQVKLCDFGVSG--EAVNSLATTFTGTSFYMAPERIQGQPYSVTSDVWSLGLTILEVANGKFPCSSEKMAANIAPFELLMWILTFTPE--LKDE---PESNIIWSPSFKSFIDYCLKKDSRERP 477
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO33652 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRL3]) HSP 1 Score: 153.295 bits (386), Expect = 1.350e-39 Identity = 131/528 (24.81%), Postives = 229/528 (43.37%), Query Frame = 1
Query: 334 KLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGG-IYDSKKEL--FNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETP------------------EDEHCDHSMGFQLSMESIVFISD------QPVIDAINNLSERISYIPQKVEDI--------------IWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFIV 1788
K++++ N + R LGKG F + +E+ + S+N++ ALK +P + S KE EI +H+ + + Y+V H D + + +++ELC +SL + G L + YLH EQ ++HRDIK N +N + ++ DFGLA + + +CGTP+Y+APE+ + GHS++ D WA G +Y M+ G+ PFET+ SL++T Y+ + Y P + R I+ +L +P+ RP+L D+ DF+ + E P D +H + Q + +D Q D N + ++ +D +++++W + F L++G + + I + DK+ ++ EDQ L R PSN++ L+ Y + LL P ++ + +S F+ WF +++ LSNG Q++ F DHTK+ ++
Sbjct: 7 KVIDNGNGRRYFRGRLLGKGGFARVYEV--TDMSTNKI--YALKVVPKKRLSKSTKEYRKIEMEIELHRTLRHHYVVGFHGSFQDEM--NFYILLELCSRKSLVQMLKTRGK--LTEPEVRFFMQQAIEACSYLH-EQRVIHRDIKVGNFFINSNMELRLGDFGLAVRLKPDEYKIRTMCGTPNYIAPEVLSKEGHSYEVDTWALGCVMYTMLVGHPPFETK----------SLRET----YRRIRNNDYTIPSRVSDSAARLIQRMLHANPENRPKLSDIFSDDFFAKGFLPNELPLTCLCGTPKWSDYEKRSTADSKKEHVLLSQALNRKLRINADEKEEQEQKSNDMCNTKLQGVAKPLLSRDDAKNHQNNKDREEFAEVFIAKWVDYSNKYGFGAQLSDGCVTVRFNDCSKIALASDKRSICYRDEDQP----LLRFSTSYVPSNLHSKVTLLT------YFANYMDKHLLKGGDP-ADVIPSHPDSIPFIDIWFRTDITMVMYLSNGAMQVNFFKDHTKVVLI 500
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO37827 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SEP8]) HSP 1 Score: 145.976 bits (367), Expect = 6.535e-37 Identity = 91/280 (32.50%), Postives = 145/280 (51.79%), Query Frame = 1
Query: 382 LGKGAFGQCFEI---DWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPET 1212
LGKG F +C+E+ D + + +++ ++ P +KE EI IH K+ +K+IV H D + +++ELC RSL + + + L + I +YLH + I+HRD+K N+ LN+ + K+ DFGLAT E+ ++ K +CGTP+Y+APE+ + GHSF+ D+W+ G LY ++ G PFETQ SL+ T Y + R +Y P ++ I +L+ DP RP + +L+ DF+ S Y T
Sbjct: 29 LGKGGFAKCYELTDLDTNKIYAGKIISKSMLTKP-----HQKEKMAMEIEIHGKVMHKHIVGFHGYFED--RDYIYILLELCPRRSLMELHKRRRA--LTEPEVRYFMKQIIDACIYLHKSR-IIHRDLKLGNLFLNDDMEVKVGDFGLATRAEEGER-KKTLCGTPNYIAPEVLSKRGHSFEVDVWSVGCILYTLLVGKPPFETQ----------SLKTT----YDRIKRNEYYIPSKVSHTAQLLIIKLLRPDPTTRPTMQQVLDDDFFKPSSGYMPT 283
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO34707 (Serine/threonine-protein kinase PLK4 [Source:UniProtKB/Swiss-Prot;Acc:A7SNN5]) HSP 1 Score: 124.79 bits (312), Expect = 1.432e-29 Identity = 80/275 (29.09%), Postives = 138/275 (50.18%), Query Frame = 1
Query: 382 LGKGAF-----GQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNR---EIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
LGKG F G+C + +A+K I + + NR E+ IH ++ + I++L+ D V +++EL N ++ + G LK + + R+ + +G++YLH GI+HRD+ NILL+ + KI+DFGLAT + + +CGTP+Y++PEI + H +SD+W+ G L+ ++ G PF+T+ R ++NK V+ +Y P + ++ I +L+K+PQ R L +L+ F
Sbjct: 19 LGKGGFACVYRGRCLATGQE---------VAIKMIDKKAMRTAG-MVNRVCNEVEIHCRLKHPSILELYTYFED--DNYVYLVLELAENGEANRYLRKQGHT-LKESEVRRIMLQVVKGVLYLH-SHGIIHRDLSLGNILLSSDMDAKIADFGLATRLSLPDEKHYTMCGTPNYISPEIATRDPHGLESDVWSIGCMLFTLLVGKPPFDTEAVRSTLNK--------------VVLAEYDIPNHVSIEARDLISKLLKKNPQDRLTLSGILDHPF 265
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO42845 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S0A9]) HSP 1 Score: 103.605 bits (257), Expect = 2.832e-24 Identity = 79/293 (26.96%), Postives = 138/293 (47.10%), Query Frame = 1
Query: 304 KCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
K E++ +S + L + LG+G++G F+ +E S ++V A+K +P D+ + +EI++ Q+ + Y+VK + + D+ ++ME C S++D + L + V +GL YLH + I HRDIK NILLN + K++DFG+A ++ + GTP ++APE+ Q+ G+ +DIW+ G+T M G P+ H +I + ++ P K F+ L K+P++R +LL+ F
Sbjct: 4 KGNELRKLSEESLTRPPEEVFDVLEKLGEGSYGSVFKAMHKE--SGQVV--AIKQVP---VDTDLQEIIKEISMMQQCDSPYVVKYYGSYFK--NTDLWIVMEYCGAGSVSDLMKIRNKT-LTEEEIKCVLKYTLKGLEYLHLRRKI-HRDIKAGNILLNSEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEVGYDCLADIWSLGITAMEMAEGKPPYADIHPMRAI-----------FMIPTKPPPTFRDPGQWSEDFKDFVSKCLVKNPEERATATELLQHSF 274
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Match: EDO44594 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RV77]) HSP 1 Score: 101.679 bits (252), Expect = 3.947e-23 Identity = 67/202 (33.17%), Postives = 108/202 (53.47%), Query Frame = 1
Query: 601 MIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQ------QYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKF--PKSAPLC--SKRFIKGILQKDPQKRPRLIDLLEQ 1176
++ E+ L D++ + + L R+ I + Y+H+ +VHRD+KP NILL+E+I+ KISDFG A ++ +T ++CGTP YLAPE+ Q G++ + D+WA GV LY ++ G+ PF H+R Q + L +N++ GKY F P+ + +K IK +L P++R D L+
Sbjct: 100 LVFEIAPKGELFDYLTEK--VTLSEKQTRRIMLSIFEAVDYMHY-HNVVHRDLKPENILLDEEINVKISDFGFAVELKE-GETLRELCGTPGYLAPEVLQCSMFPDAPGYTKEVDMWACGVILYTLLCGFPPF--WHRR----------QVVML--RNIMNGKYNFSSPEWEDVSNDAKNLIKKLLVVHPKERITASDALKH 283
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: PLK1 (polo like kinase 1 [Source:NCBI gene;Acc:101170155]) HSP 1 Score: 164.851 bits (416), Expect = 4.645e-43 Identity = 144/545 (26.42%), Postives = 238/545 (43.67%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIY--DSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSI---YPET----PEDEHCDHSMGFQLSME------------SIVFISDQP-----------VIDAINNLSERISYIP--------QKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I L++ + R LGKG F +CFEI E A K +P + ++E + EI+IH+ + + IV H D V +++E+C RSL + + ++ A + +G+ YLH + ++HRD+K NI LN+ + KI DFGLAT E + K +CGTP+Y+APE+ + GHS++ D+W+ G LY ++ G PFET +D+ N+ + + Y P + IK +L DP +RP + DL +F+ + + P T P SM +LS V + D+P + D + L+ IS P ++ ED I W+S+W + Y L + S+G +F +++ D + + + R F P+++N I +LK F Y+ + +L + + + + + ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 16 DPKSAPLKEIPEVLVDPRTLRRYSKGRFLGKGGFAKCFEITDMETKQ----VFAGKIVPKSLILKQHQREKMSSEISIHKSLNHANIVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--YMTQLLKGVHYLHSNK-VIHRDLKLGNIFLNDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEVDVWSLGCILYTLLVGKPPFETSCLKDTYNR--------------IKKNNYTIPWQINPSASALIKRMLHADPAQRPTITDLQTDEFFTSGYVPLRLPTTCLTVPPRFSIAPSMAAELSQRRPLTAINNKAGTEKVDMKDEPAPLEAEPEECYLKDMLQQLNSIISAKPSEKAVIRQEEAEDPACIPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDFTRLIMYADGDSLQYIDKKAAESYLSVRSF----PASLNKK----ITLLKYFRNYMSEHLLKAGANIARREGDELARLP----YLCLWFRTKSAIILHLSNGTVQINFFQDHTKLIL 525
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: PLK1 (polo like kinase 1 [Source:NCBI gene;Acc:101170155]) HSP 1 Score: 164.081 bits (414), Expect = 7.923e-43 Identity = 142/541 (26.25%), Postives = 237/541 (43.81%), Query Frame = 1
Query: 298 DMKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIY--DSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSI---YPET----PEDEHCDHSMGFQLSMESIV---------------FISDQP----VIDAINNLSERISYIP--------QKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPF--YIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
D K +K I L++ + R LGKG F +CFEI E A K +P + ++E + EI+IH+ + + IV H D V +++E+C RSL + + ++ A + +G+ YLH + ++HRD+K NI LN+ + KI DFGLAT E + K +CGTP+Y+APE+ + GHS++ D+W+ G LY ++ G PFET +D+ N+ + + Y P + IK +L DP +RP + DL +F+ + + P T P SM +LS + + +P + D + L+ IS P ++ ED I W+S+W + Y L + S+G +F +++ D + + + R F P+++N I +LK F Y+ + +L + + + + + ++ WF ++I LSNG QI+ F DHTKL +
Sbjct: 16 DPKSAPLKEIPEVLVDPRTLRRYSKGRFLGKGGFAKCFEITDMETKQ----VFAGKIVPKSLILKQHQREKMSSEISIHKSLNHANIVGFHGFFED--DDFVYVVLEICRRRSLLELHKRRKAVTEPEARY--YMTQLLKGVHYLHSNK-VIHRDLKLGNIFLNDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEVDVWSLGCILYTLLVGKPPFETSCLKDTYNR--------------IKKNNYTIPWQINPSASALIKRMLHADPAQRPTITDLQTDEFFTSGYVPLRLPTTCLTVPPRFSIAPSMAAELSQRRPLTAINNKGNKPNNCPKLVEAEPEECYLKDMLQQLNSIISAKPSEKAVIRQEEAEDPACIPIFWISKWVDYSDKYGLGYQLCDNSVGVLFNDFTRLIMYADGDSLQYIDKKAAESYLSVRSF----PASLNKK----ITLLKYFRNYMSEHLLKAGANIARREGDELARLP----YLCLWFRTKSAIILHLSNGTVQINFFQDHTKLIL 521
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk3 (polo like kinase 3 [Source:NCBI gene;Acc:101155385]) HSP 1 Score: 150.984 bits (380), Expect = 5.480e-38 Identity = 89/270 (32.96%), Postives = 142/270 (52.59%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY 1185
LGKG F +C+E+ + SSN++ A+K IP ++E EI +H+ + +K++VK D ++ + +ELC +SLA + L + I GL YLH+ +GI+HRD+K N +NE + ++ DFGLA E +Q K ICGTP+YLAPE+ + GH +SD+W+ G +Y ++ G PFET +++ Y+ + +Y P S +++ I GILQK+P R L +L +F+
Sbjct: 70 LGKGGFARCYEMT--DLSSNKMY--AVKVIPQSRVSKPHQREKITNEIELHRTLAHKHVVKFSHYFED--QENIYIFLELCSRKSLAHIWKARHT--LTEPEVRYYLRQIISGLKYLHN-RGILHRDLKLGNFFINENMDLRLGDFGLAAKLETVEQRKKTICGTPNYLAPEVLNRQGHGTESDVWSLGCVMYTLMCGSPPFETLDLKET--------------YKCIKEVRYNLPSSLSPAAQKLISGILQKNPSDRLTLDQILNHEFF 316
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk2b (polo like kinase 2 [Source:NCBI gene;Acc:101166557]) HSP 1 Score: 148.288 bits (373), Expect = 3.635e-37 Identity = 93/300 (31.00%), Postives = 146/300 (48.67%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVF 1275
LGKG F +C+E+ S A K IP ++E +REI +H+ + ++++V + D ++ +++E C +SLA + L + I GL YLH EQ I+HRD+K N ++E + K+ DFGLA E + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K+ I +L K P+ RP L +L DF+ T+ PE C + F +S + F
Sbjct: 57 LGKGGFAKCYEMTDLSTSK----VYAAKIIPHARVSKPHQREKIDREIELHRALNHRHVVHFYHHFED--KENIYILLEYCSRKSLAHILKARKV--LTEPEVRYYLRQIVSGLKYLH-EQEILHRDLKLGNFFVSESMELKVGDFGLAAKLEPVGNRRKTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YKCIREARYSLPSSLSPQAKQLISSLLAKIPEDRPNLDHILRHDFF-TQGFSPERLPVSCCHSAPDFHISSPAKSF 332
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Match: plk2b (polo like kinase 2 [Source:NCBI gene;Acc:101166557]) HSP 1 Score: 148.288 bits (373), Expect = 4.257e-37 Identity = 93/300 (31.00%), Postives = 146/300 (48.67%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDS--KKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVF 1275
LGKG F +C+E+ S A K IP ++E +REI +H+ + ++++V + D ++ +++E C +SLA + L + I GL YLH EQ I+HRD+K N ++E + K+ DFGLA E + ICGTP+YL+PE+ + GH +SDIWA G +Y M+ G PFET + +++ Y+ + +Y P S +K+ I +L K P+ RP L +L DF+ T+ PE C + F +S + F
Sbjct: 57 LGKGGFAKCYEMTDLSTSK----VYAAKIIPHARVSKPHQREKIDREIELHRALNHRHVVHFYHHFED--KENIYILLEYCSRKSLAHILKARKV--LTEPEVRYYLRQIVSGLKYLH-EQEILHRDLKLGNFFVSESMELKVGDFGLAAKLEPVGNRRKTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKET--------------YKCIREARYSLPSSLSPQAKQLISSLLAKIPEDRPNLDHILRHDFF-TQGFSPERLPVSCCHSAPDFHISSPAKSF 332
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000004941.1 (SMESG000004941.1) HSP 1 Score: 1113.98 bits (2880), Expect = 0.000e+0 Identity = 536/537 (99.81%), Postives = 536/537 (99.81%), Query Frame = 1
Query: 301 MKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVEDIIWVSRWAMKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFIVDKSAVLFDGKSENYEIVSVEDWCIQNTSYLDIMRTLVYSIL 1911
MKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQ FYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVEDIIWVSRWAMKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFIVDKSAVLFDGKSENYEIVSVEDWCIQNTSYLDIMRTLVYSIL
Sbjct: 1 MKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQAFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVEDIIWVSRWAMKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIFVYKWFFYCESVIFLLSNGCWQISFHDHTKLFIVDKSAVLFDGKSENYEIVSVEDWCIQNTSYLDIMRTLVYSIL 537
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000022441.1 (SMESG000022441.1) HSP 1 Score: 161.77 bits (408), Expect = 3.651e-42 Identity = 137/527 (26.00%), Postives = 231/527 (43.83%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFY--------PT-----------------------------------------KSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSERISYIPQKVED-----IIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNI---FVYKWFFYCESVIFLLSNGCWQIS-FHDHTKLFI 1785
LG+G F +C+E+ +S+NE+ + G +E +EI IH+ + N+ IVK + D +V +++ELC +SL + + I I + Y+H +Q I+HRD+K ANI LN+ + K+ DFGLAT E + K +CGTP+Y+APE+ ++ GHSF+ D W+ G +Y ++ G PFET+ RD+ Y + + +Y P + ++ I+ +L D KRP + LLE +FY PT I P DE+ ++ L + I D +I++ + S+++ + ++ E+ + WV++W + Y L++GS G + I++T + + + +++ T E L I Y D K+ K + Q ++ L N + S I +V WF +++ LSNG QI+ F DHTKL +
Sbjct: 23 LGRGGFAKCYEL---RDSNNEIFAGKIILKSGIKNSGSREKLQQEITIHRNLSNENIVKFYHYFEDNF--NVYIMLELCKCKSLLELHKRRKKI--TEPETRYFSKQIAKACEYIH-QQKIIHRDLKLANIFLNKDMIVKLGDFGLATKLEYDGERKKTMCGTPNYIAPEVLRKEGHSFEVDSWSLGCIIYTLLIGKPPFETETLRDT--------------YTKIKKNEYSIPFNLCDSTQEIIRALLDSDAMKRPSMNKLLEMEFYKGFIPSGLPTSVMTTVPRFDNIQIKNKPLSSIGNTISVPIISGIGVTGTGHSEILPGPSGDENYNNRYIVDLIRQIKNVIVDMKIINSADYPSKKMLDLMEESEEPNLAPVYWVAKWVDYSDRYGLGYQLSDGSNGVVFNDISRIILTANCQNLQYIEKNGT---------EFLY--TITSYPD---KLKKKVTLLQYFQTYMIENLMTAGENMFNDKESMIRLPYVKAWFRTKSAIVLYLSNGTVQINLFGDHTKLIV 513
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000007751.1 (SMESG000007751.1) HSP 1 Score: 144.05 bits (362), Expect = 2.795e-36 Identity = 140/531 (26.37%), Postives = 237/531 (44.63%), Query Frame = 1
Query: 382 LGKGAFGQCFE-IDWQEN--SSNELVQMALKFIPGGIYDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDFYPTKSIYPETPEDEHCDHSMGFQLSMESIVFISDQPVIDAINNLSER-------------------ISYIPQ----------KVEDIIWVSRWA-MKTLFQFYYTLNNGSIGGNIQNFKGIVVTLDKKETHFQQEDQTINSCLSRKFEELTPSNINYYCDLIIKMLKPFYIPQPILASLLSTLKPRPNLKLNMQNSNIF---VYKWFFYCESVIFLLSNGCWQISFH-DHTKLFIVD--KSAVLFDGKSE--NYEIVSVED 1851
LGKGAF +C+ ID N ++ +V+ +K + K+ +EI IH+ + +KYIV D ++ +++E C +SLA+ + ++ + I YLH + ++HRD+K ANI LN ++ K+ DFG +T + + K +CGTP+YLAPE+ + GHSF+ D+W+ GV +Y +I G PFET + D+ Y+ + Y P+ K I +L++D RP + LLE F+ K P F+LS + + D ++D+ L E ISYI K+ I WVS+W + + + +Y LN+ S G + +V L + +FQ + C ++ + + I K +K + + + L T +L ++ Q+S I + ++F ++ F+LSN Q++F DH KL + S ++ D SE Y++ S+ D
Sbjct: 25 LGKGAFAKCYALIDPDANIFATKVIVKKDVKSLIN------KDKIQKEIQIHKNLNHKYIVNFISYFQD--DKNIFIVLEYCSCQSLAELSKRRKTLLIPETRY--FTKQIVEACEYLH-DNLVIHRDLKLANIFLNSELVVKVGDFGFSTILDTEAEKKKTLCGTPNYLAPEVILKDGHSFEVDVWSLGVIIYTLIIGKPPFETSNINDT--------------YRRITSISYVIPEYLDEDVKEIILSVLKRDVNSRPTMKMLLEMSFF--KGFTPTCLPISILSCPPRFKLSKTEL--LQDGQIVDSPQLLEEYTNLKLLQQQLKDTLTNVKIISYISHPYLMKESENPKLAPIFWVSKWVDITSEYGLFYMLNDNSTGSIFNDDTRLV--LAPNDFNFQYIGCSNQECF---------YTVDDFPEKIKKKVKLIRNAKNYMNNHLMT--AGGDLVVSEQDSMIRLPNLRQFFMEPSAICFMLSNDTLQVNFQEDHVKLVLCPFMGSVMIIDENSEIKTYKLSSLHD 513
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000076532.1 (SMESG000076532.1) HSP 1 Score: 127.487 bits (319), Expect = 3.427e-30 Identity = 78/269 (29.00%), Postives = 134/269 (49.81%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGI--YDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
LG+G F + + Q+ ++A+K I + + +E+ +H ++ + I++L+ D + V +++E+C+N L I +NG + A + I GL YLH I+HRD+ AN+LL + + KI+DFGLAT E + +CGTP+Y++PE+ + ++D+W+ G LY M+ G PF+T+ R ++N+ S G++ P + S+ I G+LQ +P KR L L F
Sbjct: 19 LGRGGFARVYRAKSQKTDQ----EVAIKIIDKKMMHHHGMTARVRKEVELHSRLKHPSILELYTFFED--ANYVYLVLEMCHNGELHRRIRENGPLSEDQAR--KYLKQIVDGLKYLH-SYDILHRDLTLANLLLTKDMKIKIADFGLATQLEAGVE-HFTMCGTPNYISPEVVSRSKQGLEADVWSVGCMLYTMLVGKAPFDTKEIRGTLNRVQS--------------GRFHLPSNISESSRDLIAGLLQTNPDKRLNLQQLSNHSF 263
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Match: SMESG000076532.1 (SMESG000076532.1) HSP 1 Score: 127.487 bits (319), Expect = 3.751e-30 Identity = 78/269 (29.00%), Postives = 134/269 (49.81%), Query Frame = 1
Query: 382 LGKGAFGQCFEIDWQENSSNELVQMALKFIPGGI--YDSKKELFNREIAIHQKMCNKYIVKLHKVNIDPISGDVQMIMELCYNRSLADFINQNGSIGLKPAHMNRVCNGICRGLMYLHHEQGIVHRDIKPANILLNEKISPKISDFGLATTPEQCQQTKHKICGTPHYLAPEIFQQYGHSFQSDIWAFGVTLYFMIAGYTPFETQHQRDSINKSNSLQQTITLVYQNVIRGKYKFPKSAPLCSKRFIKGILQKDPQKRPRLIDLLEQDF 1182
LG+G F + + Q+ ++A+K I + + +E+ +H ++ + I++L+ D + V +++E+C+N L I +NG + A + I GL YLH I+HRD+ AN+LL + + KI+DFGLAT E + +CGTP+Y++PE+ + ++D+W+ G LY M+ G PF+T+ R ++N+ S G++ P + S+ I G+LQ +P KR L L F
Sbjct: 20 LGRGGFARVYRAKSQKTDQ----EVAIKIIDKKMMHHHGMTARVRKEVELHSRLKHPSILELYTFFED--ANYVYLVLEMCHNGELHRRIRENGPLSEDQAR--KYLKQIVDGLKYLH-SYDILHRDLTLANLLLTKDMKIKIADFGLATQLEAGVE-HFTMCGTPNYISPEVVSRSKQGLEADVWSVGCMLYTMLVGKAPFDTKEIRGTLNRVQS--------------GRFHLPSNISESSRDLIAGLLQTNPDKRLNLQQLSNHSF 264 The following BLAST results are available for this feature:
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Serine/threonine-protein kinase PLK vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30020085 ID=SMED30020085|Name=Serine/threonine-protein kinase PLK|organism=Schmidtea mediterranea sexual|type=transcript|length=2036bpback to top protein sequence of SMED30020085-orf-1 >SMED30020085-orf-1 ID=SMED30020085-orf-1|Name=SMED30020085-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=538bp MKCTEIKSISNKLLESFNYNKIVLKRSLGKGAFGQCFEIDWQENSSNELVback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
|
