TNF receptor-associated factor

Overview
NameTNF receptor-associated factor
Smed IDSMED30020033
Length (bp)1293
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of TNF receptor-associated factor (SMED30020033) t-SNE clustered cells

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30020033) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of TNF receptor-associated factor (SMED30020033) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for TNF receptor-associated factor (SMED30020033) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30020033

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
nervous systemSMED30020033SMESG000070155.1 dd_Smed_v4_2817_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30020033SMESG000070155.1 dd_Smed_v4_2817_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 83.5741 bits (205), Expect = 1.042e-16
Identity = 91/406 (22.41%), Postives = 174/406 (42.86%), Query Frame = 1
Query:   85 FDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSH-SIKCPYAEVGCI----ESRMDTHNIKDHL------TNETYSHTNLLI------------------ESIRNLSNEINFLKENAIRNKEMIEN-----LQIENI---------ELQNEINMINIVKMEMKTLQDGMKELKN---DSQQKNKLIYEMMRKNS--NEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            F   + D   C  C  +L    Q  CG R+C  C+   L+ +   C      C++ I  ++ +  D+   ++IL++++ C       ++ L  M  H+  H    C + E+ C+    + ++   +++DH+         T SH    +                  +SI++L N+I   +    R KEM+ N     L ++ +         EL  EI        E  +++  ++ L+N   + +  +K   ++ R       Q+    ++ S+ +I   +       L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:   43 FVKTVEDKYKCEKCHLVLCSPKQTECGHRFCESCMAALLSSSSPKC----TACQESIVKDK-VFKDNCCKREILALQIYCRNESRGCAEQL--MLGHLLVHLKNDCHFEELPCVRPDCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIALQVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 439          
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 79.7221 bits (195), Expect = 2.057e-15
Identity = 75/326 (23.01%), Postives = 131/326 (40.18%), Query Frame = 1
Query:  328 ELFCQFSDSLIVMADHMKSHSIKCPYAEVGC---------IESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAI---------------------RNKEMIEN-----LQIENI---------ELQNEINMINIVKMEMKTLQDGMKELKN---DSQQKNKLIYEMMRKNS--NEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            E  C    S + M    K     CP   V C         + S      IK H  +    H NLL E   +L  +++ L+  ++                     R KEM+ N     L ++ +         EL  EI        E  +++  ++ L+N   + +  +K   ++ R       Q+    ++ S+ +I   +       L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:  174 EATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 497          
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF3 (TNF receptor associated factor 3 [Source:HGNC Symbol;Acc:HGNC:12033])

HSP 1 Score: 79.7221 bits (195), Expect = 2.057e-15
Identity = 75/326 (23.01%), Postives = 131/326 (40.18%), Query Frame = 1
Query:  328 ELFCQFSDSLIVMADHMKSHSIKCPYAEVGC---------IESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAI---------------------RNKEMIEN-----LQIENI---------ELQNEINMINIVKMEMKTLQDGMKELKN---DSQQKNKLIYEMMRKNS--NEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            E  C    S + M    K     CP   V C         + S      IK H  +    H NLL E   +L  +++ L+  ++                     R KEM+ N     L ++ +         EL  EI        E  +++  ++ L+N   + +  +K   ++ R       Q+    ++ S+ +I   +       L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:  174 EATCSHCKSQVPMIALQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQVARNTGLLESQLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 497          
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF1 (TNF receptor associated factor 1 [Source:HGNC Symbol;Acc:HGNC:12031])

HSP 1 Score: 78.9518 bits (193), Expect = 2.385e-15
Identity = 97/407 (23.83%), Postives = 171/407 (42.01%), Query Frame = 1
Query:  175 CYHCI-EKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP--ELFCQFSDSLIVMADH----MKSHS------IKCPYAEVGC-IESRMDT--HNIKD-HLTNETYSHTNLLIESIRNLSNEI-------NFLKENAIRNKE----MIENL--------QIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRY----FKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            C  C+ E   NG ++ CPK  G   + I+    +     A+ ++    + CP   + C F  S   + +H      SH       +K   A +GC +ES       N+ D  L        +L ++  R   +E        +F+KE  +   E    + EN+        +  ++ L   I+   + +  + +L+  + EL+    QK++ + ++           E+ L+ +EE +        F   F WKI N+++   +S  G     +S +FY+   GYK+  RLY++  G    +  HL ++ V++ GEYD +L WP    VT  L+DQ         + + ++ID +      A+F RP Q   +    C       K+       V D ++FLKC V+
Sbjct:   38 CAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL-----------EQSLRLMEEAS--------FDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLN--GDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ---------NNREHAIDAFRPDLSSASFQRP-QSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVE 413          
BLAST of TNF receptor-associated factor vs. Ensembl Human
Match: TRAF1 (TNF receptor associated factor 1 [Source:HGNC Symbol;Acc:HGNC:12031])

HSP 1 Score: 78.9518 bits (193), Expect = 2.385e-15
Identity = 97/407 (23.83%), Postives = 171/407 (42.01%), Query Frame = 1
Query:  175 CYHCI-EKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP--ELFCQFSDSLIVMADH----MKSHS------IKCPYAEVGC-IESRMDT--HNIKD-HLTNETYSHTNLLIESIRNLSNEI-------NFLKENAIRNKE----MIENL--------QIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRY----FKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            C  C+ E   NG ++ CPK  G   + I+    +     A+ ++    + CP   + C F  S   + +H      SH       +K   A +GC +ES       N+ D  L        +L ++  R   +E        +F+KE  +   E    + EN+        +  ++ L   I+   + +  + +L+  + EL+    QK++ + ++           E+ L+ +EE +        F   F WKI N+++   +S  G     +S +FY+   GYK+  RLY++  G    +  HL ++ V++ GEYD +L WP    VT  L+DQ         + + ++ID +      A+F RP Q   +    C       K+       V D ++FLKC V+
Sbjct:   38 CAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL-----------EQSLRLMEEAS--------FDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLN--GDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ---------NNREHAIDAFRPDLSSASFQRP-QSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVE 413          
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-1 (TNF Receptor Associated Factor (TRAF) homolog; TRF-1 [Source:UniProtKB/TrEMBL;Acc:G5EG80])

HSP 1 Score: 67.781 bits (164), Expect = 5.424e-12
Identity = 80/352 (22.73%), Postives = 136/352 (38.64%), Query Frame = 1
Query:  106 DLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP--ELFCQFSDSLIVMADHMKS----HSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNE----------INFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKN--------------DSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAP-FEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            D  C IC+  L    +  C   YC  C E     NE   P     C+ +I        D    K+IL++ V C      C +   L  + DH+       S+KC        ++ ++ H  K  L     S  N   ++IR+   E          I+   +  + ++  +E ++       N  N+   V     T   G + ++               D     K  YE+M ++       + R+ S  E      T T+ + P   WKI+ + Q  +++K G     +S  F SH  GYKM      +G   +    + +Y +++ GE+D  L+WP ++ + I L+DQ
Sbjct:   15 DCTCPICEQALRDPIKLNCDHHYCRQCFE-----NENRTP-GCAACQTIIQPEL-CQHDRAKQKQILALPVVCTFESSGCPWDGQLGTLHDHLSECTFKSSLKCEKCGRQFAKNDLEKHRAKCELNRAVCSFCN---KTIRDSDRERHPKTCPQVIISCPFQCGLTDRPRLE-IEAHCPSCPNVDNVCPFVPYGC-TFAGGKESIQQHLSDEPVRHLMYLCDEITDLKGTYELMERDMGSFNDRQTRILSAAE------TCTEMFGPQLIWKIDKLQQRTNEAKSGADTTIFSVPFMSHRFGYKMMACACLFGDGSSAGKSISLYVLLLKGEFDPTLEWPFHRAIKISLLDQ 348          
BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Match: trf-2 (TNF Receptor Associated Factor (TRAF) homolog [Source:UniProtKB/TrEMBL;Acc:Q9N586])

HSP 1 Score: 58.5362 bits (140), Expect = 3.143e-9
Identity = 30/88 (34.09%), Postives = 46/88 (52.27%), Query Frame = 1
Query:  847 LIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ-----ILGSIYVKE 1095
            ++  +K  + R  YSQ FYSH  GYKM     PYG  +    +  V+  ++ GE+DD+L+WP    VT  ++       +  +IYV E
Sbjct:  171 VVKATKNKSHRSIYSQPFYSHGYGYKMMAVAAPYGDGLAFREYFSVFVCLMKGEWDDILEWPFRCDVTFSILSDDKKELLTKTIYVNE 258          
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf6 (gene:FBgn0265464 transcript:FBtr0071188)

HSP 1 Score: 73.9442 bits (180), Expect = 7.106e-14
Identity = 67/332 (20.18%), Postives = 139/332 (41.87%), Query Frame = 1
Query:  115 CSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP--ELFCQFSDSLIVMADHMKS---------HSIKCPYAEVGC-IESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMR--KNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLV 1062
            C+IC + L+      CG R+C  C+  ++  N + CP +     K ++   DI  D++  ++I  +K  CP   L C    S I +  H+ S            KCP+A++ C    R +T+ +++HL  +   H  L++++ +  +    +       +   +EN   +            + +  ++T+   +  L+  ++++   +  M +  + + +Q  ++ R  +      G +          W+IE +  L+ + +       YS   Y+  +GYK   RL I P    +     L ++  ++  E D  LDWP    + + +V
Sbjct:  104 CAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMD----NKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAI-ATWQPHKPSTSGAAVENGHGQQQLPPPPQYANGVDEQIVQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQAPVDPRYSN------GTIV---------WRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLNIQPRKPHV-----LSLHVHLMQSENDYHLDWPFKGRIKLCMV 410          
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0334401)

HSP 1 Score: 55.8398 bits (133), Expect = 3.825e-8
Identity = 67/273 (24.54%), Postives = 113/273 (41.39%), Query Frame = 1
Query:  367 ADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQIL--GSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDY 1179
            AD +  H+ +CP A + C + R D   I      E  +H   L +  ++L+   +F KE   R K   + L+  ++E     ++  +V +               S+Q  ++    M K++  ++ I             N T T       WKI + S  + +++  +     S  FY+   GYK++  +   G    E  H+ VY  V+ GEYD +L WP +  +T  L +Q    G   V ESF  +     F+    RPS   PD + +
Sbjct:  218 ADTLPLHAAQCPRAPLACPQ-RCDAGPIPR---GELEAH---LRDECQSLAVSCSF-KEAGCRFKGPRQMLEA-HLESNAAAHLSLMVAL--------------SSRQGQQI---QMLKSAVSKLSI-------------NYTGTLL-----WKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQ----RPSNE-PDQLGF 441          
BLAST of TNF receptor-associated factor vs. Ensembl Fly
Match: Traf4 (gene:FBgn0026319 transcript:FBtr0077429)

HSP 1 Score: 55.8398 bits (133), Expect = 4.543e-8
Identity = 67/273 (24.54%), Postives = 113/273 (41.39%), Query Frame = 1
Query:  367 ADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQIL--GSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDY 1179
            AD +  H+ +CP A + C + R D   I      E  +H   L +  ++L+   +F KE   R K   + L+  ++E     ++  +V +               S+Q  ++    M K++  ++ I             N T T       WKI + S  + +++  +     S  FY+   GYK++  +   G    E  H+ VY  V+ GEYD +L WP +  +T  L +Q    G   V ESF  +     F+    RPS   PD + +
Sbjct:  227 ADTLPLHAAQCPRAPLACPQ-RCDAGPIPR---GELEAH---LRDECQSLAVSCSF-KEAGCRFKGPRQMLEA-HLESNAAAHLSLMVAL--------------SSRQGQQI---QMLKSAVSKLSI-------------NYTGTLL-----WKITDWSAKMAEARGKDGLELVSPPFYTSQYGYKLQASMFLNGNGPGENTHVSVYIKVLPGEYDALLKWPFSHSITFTLFEQGAQSGQGGVAESFVPDPTWENFQ----RPSNE-PDQLGF 450          
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 80.4925 bits (197), Expect = 8.801e-16
Identity = 94/457 (20.57%), Postives = 167/457 (36.54%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCP-------------------------------------------KNIGNCK----KLINFNRDITIDHFANKK---ILSIKVKCP--------------ELFCQFSDSLI------VMADHMKSH--------SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEM---IENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP                                           K++  C+            + I H    K    L   + CP              E FC F++++       ++ D +  H         + C ++  GC E +M  + +  H+   T  H   + E          FL+   + N  M     +L  ++             K E+  L++ + EL+    ++++ I E+   N    N+   + ++L SLEE     L   ++   + W++EN S  +   + G     +S  FY+   GYK+  RL++  P   + + +  L V+   + GE+D  L WP+   + + ++DQ+ G  +++       +      AF RP+  R+P    Y
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCRE-KMTRNELAQHMQEFTQMHMRYMAE----------FLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTR-ELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIEVMETKPDLQ-----AFQRPTVMRNPKGFGY 494          
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 80.4925 bits (197), Expect = 8.801e-16
Identity = 94/457 (20.57%), Postives = 167/457 (36.54%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCP-------------------------------------------KNIGNCK----KLINFNRDITIDHFANKK---ILSIKVKCP--------------ELFCQFSDSLI------VMADHMKSH--------SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEM---IENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP                                           K++  C+            + I H    K    L   + CP              E FC F++++       ++ D +  H         + C ++  GC E +M  + +  H+   T  H   + E          FL+   + N  M     +L  ++             K E+  L++ + EL+    ++++ I E+   N    N+   + ++L SLEE     L   ++   + W++EN S  +   + G     +S  FY+   GYK+  RL++  P   + + +  L V+   + GE+D  L WP+   + + ++DQ+ G  +++       +      AF RP+  R+P    Y
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCRE-KMTRNELAQHMQEFTQMHMRYMAE----------FLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTR-ELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIEVMETKPDLQ-----AFQRPTVMRNPKGFGY 494          
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 80.4925 bits (197), Expect = 8.801e-16
Identity = 94/457 (20.57%), Postives = 167/457 (36.54%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCP-------------------------------------------KNIGNCK----KLINFNRDITIDHFANKK---ILSIKVKCP--------------ELFCQFSDSLI------VMADHMKSH--------SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEM---IENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP                                           K++  C+            + I H    K    L   + CP              E FC F++++       ++ D +  H         + C ++  GC E +M  + +  H+   T  H   + E          FL+   + N  M     +L  ++             K E+  L++ + EL+    ++++ I E+   N    N+   + ++L SLEE     L   ++   + W++EN S  +   + G     +S  FY+   GYK+  RL++  P   + + +  L V+   + GE+D  L WP+   + + ++DQ+ G  +++       +      AF RP+  R+P    Y
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCRE-KMTRNELAQHMQEFTQMHMRYMAE----------FLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTR-ELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIEVMETKPDLQ-----AFQRPTVMRNPKGFGY 494          
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: traf3 (TNF receptor-associated factor 3 [Source:ZFIN;Acc:ZDB-GENE-040801-257])

HSP 1 Score: 77.411 bits (189), Expect = 7.413e-15
Identity = 80/340 (23.53%), Postives = 142/340 (41.76%), Query Frame = 1
Query:  307 SIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGC-----------IESRMDTHN---IKDHLTNETYSHTNL----------LIESIRNLSNEINFLKENAIRNKEMIE-NLQIEN------------------IELQ-NEINMINIVKMEMKTLQDGMKELKN-----DSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS 1152
            +  V CP   C FS    ++   + SH   CP A+V C           +   M  H      +HL      +T L          L+E  + L +  + L E   + +EM E N Q+E                   +E++  E+  +  ++ E++TL+  ++ +++     DS   N         +  +Q+     L S+ ++           L    F     WKI +  +   ++ +      YSQ FY+   GYKM  R+Y++  G  + +  HL ++FVV+ GEYD +L WP  + VT+ L+DQ     ++ ++FK +       ++F RP+
Sbjct:  201 AFPVACPN-HCSFSS---ILRSELSSHQHDCPKAQVTCSFIRYGCSYKGLNQEMREHESSFASEHLRMMAVRNTTLEAKVEDVKSELMERYKVLPSLSSRLAEVERQYEEMREKNRQLEQKLVSMQMLMSSHSEKLLEVEMELRELRPLRAMREEVETLRGSVESMRSMVSSLDSSCVNSASGSHTLASLEQQLTRHDDLMSVHDVRLAEMDLKLQVLETASFNGTLIWKIRDYKRRKQEAVVSKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVVMRGEYDALLQWPFKQKVTLMLMDQGPARKHLGDAFKPDPSS----SSFRRPT 530          
BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Match: unm_sa808 (un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21])

HSP 1 Score: 71.633 bits (174), Expect = 1.429e-13
Identity = 55/225 (24.44%), Postives = 111/225 (49.33%), Query Frame = 1
Query:  418 CIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRN-KEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLK----SLEEINEGNL---TNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            C+ S+++   I +H     + H NLL+  I  +   +  L++  + +     ++L+++    ++ + ++N    E++     M+     S ++++L  + +   SN+   +E+++     ++ E+ EG L   + T F   F W+I + ++    +  G     +S +FY+   GYKM L I   G       HL ++FVV+ G  D +L WP N+ VT+ L+DQ
Sbjct:    1 CLPSKVEKEKIHEHERACAHEHLNLLLHYIMGMKVSLEGLEKTKVADLGRRCQDLEVKAGTFEDVVCVLN---REVERFATTMEA----SNRQHRLDQDKIEALSNKVRQLERQVGVKDLTVAEM-EGRLREMSATTFDGVFIWRISDFTKKRQDAIAGRAPAMFSPAFYTSKYGYKMCLRIYLNGDGTGRGTHLSLFFVVMRGMSDALLKWPFNQKVTLMLLDQ 217          
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 83.5741 bits (205), Expect = 1.186e-16
Identity = 101/447 (22.60%), Postives = 172/447 (38.48%), Query Frame = 1
Query:  115 CSICKNILHIASQNICGCRYCYHCIEKYLNGN-----------------------------EKFCPKNIGNCKKLINFN-------RDITIDHFAN----------KKILS--IKVKCP--ELFCQFSDSLIVMADHMKSHSIKCPYAEVGC---------IESRMDTHNIKDHLTNETYSHTNLLIE---------------------SIRNLSNEINFLKENAIRNKEMIENLQIENIELQ----NEINMINIVKMEMKTLQ------DGMKELKNDSQQKNKLI-YEMMRKNS--------NEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            C  C+ +L    Q  CG R+C  C+   L+                               + FC      CK+LI           D   +  +           +K LS  I+  C   E  C+F  + + + +  K   + CP   + C         + S      IK H  +    H NL+ E                     SI+ L N++   +    R+KE + N +   I+LQ     + + +  +  E++ L+      DGMK   N    +N+L   E+M KN+          QI    ++ S+ +I   +       L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + V++ L+DQ     ++ ++FK +     FK
Sbjct:   48 CEKCRLVLCNPRQTECGHRFCETCMNAILSSTSPQCMACEDNITKDKVFKDNCCRREVLALQMFCRNETRGCKELITLGNLLIHLKSDCQFEELSCPRADCKEKVIRKDLSDHIEKTCKYRETPCKFCRNQVPLVEMQKHEDVDCPSVVISCPHMCSVKSLLRSEGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKS--NYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPDPNSSSFK 490          
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 80.4925 bits (197), Expect = 8.212e-16
Identity = 94/387 (24.29%), Postives = 154/387 (39.79%), Query Frame = 1
Query:   64 LNKFDF---VFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEK---YLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELF--CQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTH--NIKDH--------LTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIEN---LQIENIELQNEI--------------NMINIVKMEMK---------TLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLE--------EINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            LN+  F   +  + L    LCS CKN+L    Q  CG RYC HC+ K   ++  N    P+    C++       I++ H         + KCP L   C    ++I  A+       +CP  ++ C   ++  +  +IK H        +T E      +  E +R         +  A+   EM+EN   L+ EN  L   +              N   + +M +K         T ++ +  L  + ++ +    E+ R+       +E+ L   E         + E  L+   +   F WKI    +    +  G     +S  FY++  GYKM L I   G       HL ++FVV+ G  D +L WP N+ VT+ L+DQ
Sbjct:   17 LNQPGFKKEILGTKLEVKYLCSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGH---------EGKCPYLLAPCPACKTIIRAANRDLHSERECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCEGCGRKKIPREKVRLFV--CMPCRYAAVGCTEMVENDKCLEHENKSLAEHLAKGSPAPPANAPPNNSAKVAEMLLKFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQLRAADTRLERTLGQKELIVAELETRMQESELST--YDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 390          
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: TRAF2 (TNF receptor associated factor 2 [Source:NCBI gene;Acc:100494415])

HSP 1 Score: 78.5666 bits (192), Expect = 4.358e-15
Identity = 96/410 (23.41%), Postives = 158/410 (38.54%), Query Frame = 1
Query:   64 LNKFDF---VFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEK---YLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELF--CQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTH--NIKDH--------LTNETYSHTNLLIESIR----NLSNEINF---LKENAIRNKEMIEN---LQIENIELQNEINMI-----------NIVKMEMKTLQ-DGMKELKNDSQQKNKLIYE--------MMRKNSNEQILIEKRLKSLEEINEGNLTNTK---------------------------FYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            LN+  F   +  + L    LCS CKN+L    Q  CG RYC HC+ K   ++  N    P+    C++       I++ H         + KCP L   C    ++I  A+       +CP  ++ C   ++  +  +IK H        +T E      +  E +R    + S  I      +  A+   EM+EN   L+ EN  L   +  +           N + + M +L   G      D+  K    +E         + ++S+    + ++L++ +E  E   T  +                           +   F WKI    +    +  G     +S  FY++  GYKM L I   G       HL ++FVV+ G  D +L WP N+ VT+ L+DQ
Sbjct:   17 LNQPGFKKEILGTKLEVKYLCSDCKNLLRRPLQAQCGHRYCSHCLNKIIRWVARNWGGVPECPAVCERSDWTGALISVGH---------EGKCPYLLAPCPACKTIIRAANRDLHSERECPERKLNCRYCKLSFYFPDIKAHDEICPKFPMTCEGCGRKKIPREKVRLFVCSFSRNITLSLPCRYAAVGCTEMVENDKCLEHENKSLAEHLAKVWDYIQHGRKEQNDLSVRMGSLSVQGSPAPPFDTLDKKNTTFENIVSVLNREVERSSHAAEELARQLRAAQEKVEALTTKVRQLERTLGQKELIVAELETRMQESELSTYDGVFIWKISEFGKKRQDAINGRCPAMFSPPFYTNKYGYKMCLRIYLNGDGTGRNTHLSLFFVVMKGNNDALLRWPFNQKVTLMLLDQ 417          
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: ssh2 (slingshot protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-993093])

HSP 1 Score: 77.0258 bits (188), Expect = 1.619e-14
Identity = 80/330 (24.24%), Postives = 141/330 (42.73%), Query Frame = 1
Query:  307 SIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDT------HNIKDHLTNETYSHTNLLIE---------------------SIRNLSNEINFLKENAIRNKEMIENLQIENIELQ----NEINMINIVKMEMKTLQ------DGMKELKNDSQQKNKLI-YEMMRKNS--------NEQILIEKRLKSLEEINEGN-------LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            S+ + CP + C       ++   + +H ++C  A   C   R           IK H  +    H NL+ E                     SI+ L N++   +    R+KE + N +   I+LQ     + + +  +  E++ L+      DGMK   N    +N+L   E+M KN+          QI    ++ S+ +I   +       L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + V++ L+DQ     ++ ++FK +     FK
Sbjct:  194 SVVISCPHM-CSVKS---LLRSELNAHLLECVNAPSTCSFKRYGCTFKGTNQQIKAHEASSAVQHVNLMKEWSNYLEAKVSMLQNESSEKNKSIQILHNQMCSFEIEIERHKEQLRNNEARIIQLQRVIEGQADKLKDLDKEIRNLRQTGDEADGMKS--NYESLQNRLSQLEVMAKNAASWNPGVLETQINRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVSLMLMDQGPSRRHLGDAFKPDPNSSSFK 515          
BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Match: egf (epidermal growth factor [Source:Xenbase;Acc:XB-GENE-951823])

HSP 1 Score: 73.559 bits (179), Expect = 1.887e-13
Identity = 60/280 (21.43%), Postives = 124/280 (44.29%), Query Frame = 1
Query:  388 SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSN---------EINFLKENAIRN-KEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
             I C Y E GC E +M  +++  HL   T +H  ++ +++R+ S+         +I+F   +        +  +   +   QN+         E + L++ +++L+    +++  I E++ K   +   + +   ++  ++   G + + +    F W+I N + L+   +       +SQ FY+   GYK+  RL++  P   +   Y  L V+   + GEYD +L WP+   + + ++DQ  G     +    ++       AF RP+  R+P    Y
Sbjct:  241 PIPCMYYEFGCTE-KMQRNDLARHLQEFTQAHMRMMAQTLRSFSSSVTPTSHMPDISFCDPSQFEPAPPSVATVHSSHTPSQNDCTQ------ETRNLRETIEQLEGRLVRQDHQIRELIAKMETQCTYVNELKHTIRSLDNRLGEMESQQCSGIFIWRINNFNSLLKNQEEERPVVIHSQGFYTGKPGYKLCLRLHLQLPSAQRCANYISLFVH--TMQGEYDSLLPWPLQGTIRLSILDQSEGVAMQDQEEVMDTKPELL--AFQRPTVARNPKGFGY 509          

HSP 2 Score: 60.8474 bits (146), Expect = 2.371e-9
Identity = 41/134 (30.60%), Postives = 64/134 (47.76%), Query Frame = 1
Query:   64 LNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGC--IESRMDTHNIKDH 459
            +  +D  FD  L     C IC   L  A Q  CG R+C  CI K +      CP  + N   + N    +  D+FA ++ILS++VKCP   C  +  L     H++ H ++C +A V C   +S    ++++ H
Sbjct:   55 VQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACILKSIRDAGHKCP--VDNESLMEN---QLFPDNFAKREILSLRVKCPSQGCTETMEL----RHLERHLVRCDFAGVECSQCQSSFPKYSLQKH 179          
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 80.8777 bits (198), Expect = 6.286e-16
Identity = 99/463 (21.38%), Postives = 175/463 (37.80%), Query Frame = 1
Query:   85 FDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKV-------KCPELF------------CQFSDSLIVMAD--------------------------HMKSH----------SIKCPYAEVGC---------IESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAI---------------------RNKEMIEN-----LQIENI---------ELQNEINMI-------NIVKMEMKTLQDGMKELKN------DSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            F   + D   C  C+ +L    Q  CG R+C  C+   L+ +   C      C++ I     +  D+   ++IL+++V        C E              CQF +   + AD                          H KS              CP   V C         + S      IK H  +    H NLL E   +L  +++ L+  ++                     R KEM+ N     L ++ +         EL  EI          + +K  +++LQ+ + EL++       + +   L+   + ++     + + RL  ++ +    L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:   42 FVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQESI-IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMD-LRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 496          
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 80.8777 bits (198), Expect = 6.286e-16
Identity = 99/463 (21.38%), Postives = 175/463 (37.80%), Query Frame = 1
Query:   85 FDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKV-------KCPELF------------CQFSDSLIVMAD--------------------------HMKSH----------SIKCPYAEVGC---------IESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAI---------------------RNKEMIEN-----LQIENI---------ELQNEINMI-------NIVKMEMKTLQDGMKELKN------DSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            F   + D   C  C+ +L    Q  CG R+C  C+   L+ +   C      C++ I     +  D+   ++IL+++V        C E              CQF +   + AD                          H KS              CP   V C         + S      IK H  +    H NLL E   +L  +++ L+  ++                     R KEM+ N     L ++ +         EL  EI          + +K  +++LQ+ + EL++       + +   L+   + ++     + + RL  ++ +    L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:   42 FVKTVEDKYKCEKCRLVLCNPKQTECGHRFCESCMAALLSSSSPKCTA----CQESI-IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLKNECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVSCPHKCSVQTLLRSEGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMD-LRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 496          
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf3 (TNF receptor-associated factor 3 [Source:MGI Symbol;Acc:MGI:108041])

HSP 1 Score: 77.0258 bits (188), Expect = 1.036e-14
Identity = 68/295 (23.05%), Postives = 128/295 (43.39%), Query Frame = 1
Query:  397 CPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAI---------------------RNKEMIEN-----LQIENI---------ELQNEINMI-------NIVKMEMKTLQDGMKELKN------DSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            C +   GC+  +     IK H  +    H NLL E   +L  +++ L+  ++                     R KEM+ N     L ++ +         EL  EI          + +K  +++LQ+ + EL++       + +   L+   + ++     + + RL  ++ +    L    +     WKI +  +   ++ +G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FV++ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     FK
Sbjct:  231 CSFKRYGCV-FQGTNQQIKAHEASSAVQHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILHLQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLESQLSRHDQMLSVHDIRLADMD-LRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAFKPDPNSSSFK 521          
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 75.8702 bits (185), Expect = 2.367e-14
Identity = 62/249 (24.90%), Postives = 109/249 (43.78%), Query Frame = 1
Query:  370 DHMKSHS---IKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTL--------------QDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVD 1065
            DH+++ S   + C +  VGC E  ++T N++DH       H  LL+ S          L +      E+++  QI   ++    N++ ++  E++ +              QD ++ L N  QQ  + I            L +  +  LE+     L  + +   F WKI + ++   ++  G     +S +FY+   GYKM L +   G       HL ++FVV+ G  D +L WP N+ VT+ L+D
Sbjct:  211 DHVRACSKCRVLCRFHTVGCSE-MVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQV---GPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIG-----------LKDLAMADLEQ-KVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD 443          
BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Match: Traf2 (TNF receptor-associated factor 2 [Source:MGI Symbol;Acc:MGI:101835])

HSP 1 Score: 75.8702 bits (185), Expect = 2.525e-14
Identity = 62/249 (24.90%), Postives = 109/249 (43.78%), Query Frame = 1
Query:  370 DHMKSHS---IKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTL--------------QDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVD 1065
            DH+++ S   + C +  VGC E  ++T N++DH       H  LL+ S          L +      E+++  QI   ++    N++ ++  E++ +              QD ++ L N  QQ  + I            L +  +  LE+     L  + +   F WKI + ++   ++  G     +S +FY+   GYKM L +   G       HL ++FVV+ G  D +L WP N+ VT+ L+D
Sbjct:  204 DHVRACSKCRVLCRFHTVGCSE-MVETENLQDHELQRLREHLALLLSSFLEAQASPGTLNQV---GPELLQRCQILEQKIATFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIG-----------LKDLAMADLEQ-KVSELEVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTHLSLFFVVMKGPNDALLQWPFNQKVTLMLLD 436          
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q6IWL4|TRAF6_DANRE (TNF receptor-associated factor 6 OS=Danio rerio OX=7955 GN=traf6 PE=1 SV=2)

HSP 1 Score: 80.4925 bits (197), Expect = 6.643e-15
Identity = 94/457 (20.57%), Postives = 167/457 (36.54%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCP-------------------------------------------KNIGNCK----KLINFNRDITIDHFANKK---ILSIKVKCP--------------ELFCQFSDSLI------VMADHMKSH--------SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEM---IENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP                                           K++  C+            + I H    K    L   + CP              E FC F++++       ++ D +  H         + C ++  GC E +M  + +  H+   T  H   + E          FL+   + N  M     +L  ++             K E+  L++ + EL+    ++++ I E+   N    N+   + ++L SLEE     L   ++   + W++EN S  +   + G     +S  FY+   GYK+  RL++  P   + + +  L V+   + GE+D  L WP+   + + ++DQ+ G  +++       +      AF RP+  R+P    Y
Sbjct:   57 YDVEFDPPLESKYECPICLMGLRSAVQTPCGHRFCDSCIRKSIRDTGQKCPVDNEVLLEEQLFPDNFAKREILSLTVKCSNFGCSEKMELRQLEKHLSQCRFATAPCPQCQESVPISHLDEHKSQHCLQRIMTCPDCAGSFVYAVKQNHEQFCPFANTVCEYCEMELIRDQLALHCDTDCLKAPVACTFSTFGCRE-KMTRNELAQHMQEFTQMHMRYMAE----------FLRSQTLNNCTMPSAAAHLSSDDRGASARSPDSCQCKQELLNLRETVLELEGRLVRQDQQIRELCIHNDTQKNQVTELRRKLVSLEESTR-ELEAQQYQGIYVWRVENFSHHLRNQEAGQPIVLHSPPFYTGRPGYKLCLRLHLQTPSAPRCSNFISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQVEGQHHIEVMETKPDLQ-----AFQRPTVMRNPKGFGY 494          
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|Q13077|TRAF1_HUMAN (TNF receptor-associated factor 1 OS=Homo sapiens OX=9606 GN=TRAF1 PE=1 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 1.145e-14
Identity = 97/407 (23.83%), Postives = 171/407 (42.01%), Query Frame = 1
Query:  175 CYHCI-EKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP--ELFCQFSDSLIVMADH----MKSHS------IKCPYAEVGC-IESRMDT--HNIKD-HLTNETYSHTNLLIESIRNLSNEI-------NFLKENAIRNKE----MIENL--------QIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRY----FKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            C  C+ E   NG ++ CPK  G   + I+    +     A+ ++    + CP   + C F  S   + +H      SH       +K   A +GC +ES       N+ D  L        +L ++  R   +E        +F+KE  +   E    + EN+        +  ++ L   I+   + +  + +L+  + EL+    QK++ + ++           E+ L+ +EE +        F   F WKI N+++   +S  G     +S +FY+   GYK+  RLY++  G    +  HL ++ V++ GEYD +L WP    VT  L+DQ         + + ++ID +      A+F RP Q   +    C       K+       V D ++FLKC V+
Sbjct:   38 CAGCLSENPRNGEDQICPKCRGEDLQSISPGSRLRTQEKAHPEVAEAGIGCPFAGVGCSFKGSPQSVQEHEVTSQTSHLNLLLGFMKQWKARLGCGLESGPMALEQNLSDLQLQAAVEVAGDLEVDCYRAPCSESQEELALQHFMKEKLLAELEGKLRVFENIVAVLNKEVEASHLALATSIHQSQLDRERILSLEQRVVELQQTLAQKDQALGKL-----------EQSLRLMEEAS--------FDGTFLWKITNVTRRCHESACGRTVSLFSPAFYTAKYGYKLCLRLYLN--GDGTGKRTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQ---------NNREHAIDAFRPDLSSASFQRP-QSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVE 413          
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B5DF45|TRAF6_RAT (TNF receptor-associated factor 6 OS=Rattus norvegicus OX=10116 GN=Traf6 PE=2 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 2.234e-14
Identity = 98/439 (22.32%), Postives = 169/439 (38.50%), Query Frame = 1
Query:   64 LNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADH----------------------MKSHSIK-CPYAEVGCIESRM-------DTHNIKDHLTN--ETYSHTNLLIESIRN------------LSNEINFLKENAIRN---KEMIENLQIENIELQNEINMINI-------------VKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILI---EKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +  +D  FD  L     C IC   L  A Q  CG R+C  CI K +      CP +       I     +  D+FA ++ILS+ VKCP   C     L  + DH                      +  H I+ CP  +V C+   +       + H+    L N    Y  T L+ E + N             +  +    E   RN   + + EN Q+    L   ++ +N+              + E    ++ +K+L+    +++  I E+  K   + + +   ++ ++SLE+     +   +    + WKI N    +   +       +S  FY+   GYK  MRL++  P   +   Y  L V+   + GEYD  L WP    + + ++DQ      ++++ +     +    AF RP+  R+P    Y
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACITKSIRDAGHKCPVD-----NEILLENQLFPDNFAKREILSLTVKCPNKGCVQKMELRHLEDHQVHCEFALVICPQCQRFFQKCQINKHIIEDCPRRQVSCVNCAVPMPYEEKEIHDQSCPLANIICEYCGTILIREQMPNHYDLDCPTAPVPCTFSVFGCHEKMQRNHLARHLQENTQLHMRLLAQAVHNVNLSLRPCDASSPSRGCRPEDPNYEETVKQLEGRLVRQDHQIRELTAKMETQSMHVSELKRTIRSLED-KVAEMEAQQCNGIYIWKIGNFGMHLKSQEEERPVVIHSPGFYTGRPGYKLCMRLHLQLPTAQRCANYISLFVH--TMQGEYDSHLPWPFQGTIRLTILDQ--SEAVIRQNHEEVMDAKPELLAFQRPTIPRNPKGFGY 481          
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B6CJY4|TRAF6_CERAT (TNF receptor-associated factor 6 OS=Cercocebus atys OX=9531 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 6.730e-14
Identity = 93/434 (21.43%), Postives = 165/434 (38.02%), Query Frame = 1
Query:   64 LNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESR-------MDTHNIKDHLTNET-----------------------------YSHTNLLIESIRN------------LSNEINFLKENAIRN---KEMIENLQIENIELQNEINMINIVK-----MEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +  +D  FD  L     C IC   L  A Q  CG R+C  CI K +      CP +       I     +  D+FA ++ILS+ VKCP   C     L     H++ H   C +A V C + +       ++ H +KD    +                              Y +T L+ E + N             +       E   RN   + + EN Q     L   ++ ++++       E++  Q+ + +L+    +++  I E+  K   +   + +  +++  + +    +   +    + WKI N    +   +       +S  FY+   GYK  MRL++  P   +   Y  L V+   + GEYD  L WP    + + ++DQ      V+++ +     +    AF RP+  R+P    Y
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD-----NEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMEL----RHLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVH--TMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKGFGY 473          
BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Match: sp|B6CJY5|TRAF6_MACMU (TNF receptor-associated factor 6 OS=Macaca mulatta OX=9544 GN=TRAF6 PE=2 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 7.165e-14
Identity = 93/434 (21.43%), Postives = 165/434 (38.02%), Query Frame = 1
Query:   64 LNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESR-------MDTHNIKDHLTNET-----------------------------YSHTNLLIESIRN------------LSNEINFLKENAIRN---KEMIENLQIENIELQNEINMINIVK-----MEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +  +D  FD  L     C IC   L  A Q  CG R+C  CI K +      CP +       I     +  D+FA ++ILS+ VKCP   C     L     H++ H   C +A V C + +       ++ H +KD    +                              Y +T L+ E + N             +       E   RN   + + EN Q     L   ++ ++++       E++  Q+ + +L+    +++  I E+  K   +   + +  +++  + +    +   +    + WKI N    +   +       +S  FY+   GYK  MRL++  P   +   Y  L V+   + GEYD  L WP    + + ++DQ      V+++ +     +    AF RP+  R+P    Y
Sbjct:   53 IQGYDVEFDPPLESKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVD-----NEILLENQLFPDNFAKREILSLMVKCPNEGCLHKMEL----RHLEDHQAHCEFALVDCPQCQRPFQKFHINIHILKDCPRRQVSCDNCAALVAFEDKEIHDQNCPLANVICEYCNTILIREQMPNHYDLDCPTAPIPCTFSTFGCHEKMQRNHLARHLQENTQSHMRMLAQAVHSLSLIPDSGYVSEVRNFQETIHQLEGRLVRQDHQIRELTAKMETQSTYVSELKRTIRTLEDKVAEIEAQQCNGIYIWKIGNFGMHLKCQEEEKPVVIHSPGFYTGKPGYKLCMRLHLQLPTAQRCANYISLFVH--TMQGEYDSHLPWPFQGTIRLTILDQ--SEAPVRQNHEEIMDAKPDLLAFQRPTIPRNPKGFGY 473          
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: T1E101 (TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 142.51 bits (358), Expect = 4.491e-34
Identity = 128/428 (29.91%), Postives = 202/428 (47.20%), Query Frame = 1
Query:   61 LLNKFDF-VFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKK-LINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHM---KSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINF----LKENAIRNKEMI---------ENLQIENI--ELQNEINMINI-------VKMEMKTL----QDGMKELKNDSQ--------QKNKL-------IYEMMRKNSNEQILIEKRLKSLEEINE---GNLTNTKFYAP-----FEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYC 1182
            LL+K++    D ++++DLLC +C  ++  A ++ CGC YCY CI  YL+ N  +CP +   CK+  +N   D+  +   + +I  I VKCP + C ++  L+ + +H+      S++CP   +GC E  +    +  HLT++   HT L++     L +EIN      KE+    KE++         +  Q+E +  EL+N+ NMI +       VK EM TL    +  +K+LK+D Q         KN L       I   ++    E   I+  + S  E  E    NL       P     F W+IE  S+     K       YS SF SH   + + LYI  YG       +L ++ V++ GE DD L+WPM + VT+ +++Q     +    F+ ++  R  K AFDRP        DYC
Sbjct:   12 LLSKYNVKRVDESVNNDLLCILCNKLMRDACESACGCHYCYTCIRIYLSQNHNYCPGDKTECKEDYLNLEGDVFRNIRLSTRISRIVVKCPNIRCNYTSELLRLKEHLDKCTPESVECPCVTIGCEEEPLLKDEMAKHLTDQVLRHTQLIMSFCNELKSEINHNNETTKEDISHLKEVLRVQKALNDEKTAQMEFLIEELRNKDNMILVLSQDIQEVKNEMITLLTSKESELKKLKSDIQIFRQEIEFMKNDLEVVGSTDIKNQVKDLKKEIFGIKMNIDSNNEERERKMNNLIRLNKLCPNVDMDFMWRIEEYSK-----KRRTVTDVYSDSFQSHNYKFCLNLYI--YG------DNLGLWCVIMKGEKDDFLEWPMRRTVTLSIIEQDSLKTHKTTVFQYDTYQRN-KKAFDRPKDERN---DYC 422          
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: I1ZID8 (TNF receptor associated factor-2 (Fragment) OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 111.694 bits (278), Expect = 5.805e-25
Identity = 64/196 (32.65%), Postives = 111/196 (56.63%), Query Frame = 1
Query:   46 EEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKL-INFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIK---CPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMI 621
            E+   LL  ++F  +  + D+L C +CKN+L  A Q+ CGCR+C  CI +Y++    +CP     CK+  +    +I  D+  N+KI  ++VKCPE  C+    L+ + +H++  ++K   CP+  +GC + +M   ++ +HL N T+ H+ L+I+ I N+ N+   L    +  +E I NL   + + QNEI M+
Sbjct:    4 EKINRLLITYNFEVEGGVPDNLKCDLCKNLLVNACQSRCGCRFCSKCIMEYVSRGNLYCPGGTSECKEENLTICSNIHTDYRVNRKIAKMRVKCPEETCKVYCELVDIEEHLRLCTMKSQNCPFFVLGCNQPKMVIQDLTNHLQNGTFQHSKLIIDIISNMRNDFFGLTTKEVELREDI-NLIKNHFQSQNEIMML 198          
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: T1DBK6 (TRAF-4 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1)

HSP 1 Score: 115.931 bits (289), Expect = 1.262e-24
Identity = 111/401 (27.68%), Postives = 175/401 (43.64%), Query Frame = 1
Query:   67 NKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKD---HLTNET------------------YSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQ----IENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKL-IYEMMRKNSNEQILIEKRLKSLEEINE---GNLTNTKFYAP------------------------FEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKAN 1110
            NK+ F     ++D+L C +C++IL  A Q  CGCRYC  CI+ YL   EK C     +C+ +I        D   NK+I  +KVKC    C F D+L      +K H   C Y    C    M+ + IK+   HL NE                   Y+ ++L  ES R+L  +   +       +  +  L      EN  L+  +++ +  ++  K   D M E  N S  ++ L I   +RK   +   +E+R+  L E N+     L   K   P                        + WKI++ S+L + +  G      S++FY+   GYKM + I P G  + +  HL ++FV++ G+YDD+L WP    V I + D    S  + ++FK +
Sbjct:   19 NKWRFT----INDNLKCVMCQDILLDAIQTDCGCRYCKECIDNYLENGEKECVAEYEDCRSVIT---SYIYDRATNKEISLLKVKCLYEGCVFEDTL----KSIKGHLDFCEYRNEMCSLCGME-YIIKEESNHLANECLLREVLCQYCRTLLTFKEYNESHLCFES-RDLCGKYEAICPYGCTGESKVNLLHHRKSCENKPLECPLHVFDCKQLIPK---DQMTEHLNTSSYEHTLTIVTELRKLEKQNKHMEERMNILIEENQLLKATLEVMKLDLPKNSGSISRDTSLKRANKTIFRNGKYMWKIKSFSKLRENAMRGKNPTILSEAFYTSDFGYKMCMKIYPCGDGVGKGTHLSIFFVIMKGDYDDILPWPFKNKVIITIFDDFSKSTNLSDTFKPD 403          
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A2B4SJ65 (TNF receptor-associated factor 4 OS=Stylophora pistillata OX=50429 GN=Traf4 PE=4 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 1.523e-24
Identity = 91/364 (25.00%), Postives = 158/364 (43.41%), Query Frame = 1
Query:   49 EAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGC----IESRMDTHNIKDHLT-------------------NETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAP-FEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            E+  L   +D+ F S + +D +C IC   L  A    CG R+C  C+ ++   N   CP +    ++ ++ ++D+  D  + ++ILS  +KCP+  CQ+   L  +  H K    KCPY  V C       RM  + +++H                      E + H         N SN         +  +E +E   +E    ++  + +     ++  LQ   +E   +++   K + ++  K  NE +L++   +      E  +  +K   P F WK+     ++ Q+K G      S  FY+   GYK++L ++P G       HL  + +V+ GE+D +L WP N  VT  LVDQ
Sbjct:    6 ESGELPTGYDYDFVSEIDEDFICQICHLPLRNAVLTRCGHRFCVDCLNEHFRRNSPNCPLD----REKLDKDKDVFPDKASQRRILSYLIKCPDK-CQWVGELRDVEGHKK----KCPYVIVQCPNHNCHERMARNLVEEHAAVTCQWRMVSCQFCQKKYPKAEEHIHCETCHMFPLNCSNGCE-----QVVPREQVERRNLETHIHEDTTSHLGFACKKLAVLQ---QEFNKENKTLKKQLDDV--KKENENLLLKASAQ------EKEMQKSKMETPTFVWKVTGFDDILRQAKHGRNNEMDSDPFYTGKYGYKLKLSVNPNGDGSGRNTHLSAFVIVMRGEHDGILPWPFNHKVTFTLVDQ 344          
BLAST of TNF receptor-associated factor vs. TrEMBL
Match: A0A5A9NXF1 (TNF receptor-associated factor OS=Triplophysa tibetana OX=1572043 GN=E1301_Tti007446 PE=3 SV=1)

HSP 1 Score: 115.161 bits (287), Expect = 3.719e-24
Identity = 107/433 (24.71%), Postives = 193/433 (44.57%), Query Frame = 1
Query:   67 NKFDFVFDSNLSDDL-----LCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKF-CPKNIGNCKKLINFNRD---ITIDHF-----ANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYA---------------------EVGCI----------------ESRMDTHNIKDHLTNETYSHTNLLIESIR----NLSNE-------INFLK---------------------ENAIRNK---------EMIENLQIENIELQNEI--NMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKR---LKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            N++   F  ++ D++     LCS C N+L+ A Q +CG RYC  C+   L  N+   C K    CK+  +   D   +T+D F      NK+IL +KV C    C +  +L    DH      +C YA                     E GC                 E + +   +K+H +     H  LL+E IR    NLS++       ++FL+                     E+ + +K         E+    Q++ ++ + ++  N+I+ +  E++  Q G+  L+ D+    ++I ++  K   +Q  + ++   + SL++   G L N  +   F W++ +++Q + ++  G++   YS +FY+   G+K  MRLY++  G  + +  H+ ++FV++ GEYD +L WP    VT  L+DQ
Sbjct:   19 NEYPSGFPQSICDEVPKEKFLCSNCNNVLNKARQTVCGHRYCLACVNWLLRNNKDLVCTK----CKEDQSIESDTSVLTLDQFFNDAAINKEILDLKVHCANQGCPWRSTLKNFEDHQS----QCEYALIPCNIGCGIMVQRKALATHLERGCPNNKTTCASCSGVLTPRELQGNADKVKEHESCSHVGHLQLLLEVIRGLQSNLSSQERGIPEILDFLQPGTTGSSLVSHEESELETDGGESGVNDKASSLHDDQAELAVGQQLDTLQQRVQVMENIISALNREVEKTQIGVVALERDNLNNQQIIQQLETKVEEQQEWLTRKDIHITSLQQCISG-LQNVSYDGTFLWRLCDVTQSLREAATGHKISQYSPAFYTARYGFKVCMRLYLN--GDGVGKGTHISLFFVIMKGEYDGILQWPFRHKVTFFLIDQ 440          
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf1 (TNF receptor-associated factor 1-like [Source:NCBI gene;Acc:103045252])

HSP 1 Score: 87.4261 bits (215), Expect = 3.011e-18
Identity = 75/330 (22.73%), Postives = 150/330 (45.45%), Query Frame = 1
Query:  397 CPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIEL-----------------QNEINM---INIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSN---------------EQILIEKRLK--SLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            C ++E+GC   + +   +++H  + T +H +LL+E +RN+   +    E  ++   +   L    +E                  Q E+ +   ++ ++  ++ +++ +  L  + ++    +  + R N N               +Q LI K L+  SL++       +  +   F W+I ++SQ + ++  G +   YS +FY+   G+K  MRLY+  YG  + +  H+ ++FV++ G+YD +L WP  + VT  L+DQ     +V ++F+ +       A+F RP     +    C       K+       V D ++F+KC VD
Sbjct:  196 CVFSEIGCT-FKGNPDKVREHEVSSTSAHLHLLVEVVRNVQMSVPPPPERTVQYPALDLTLNGGELETDSGDTGANDKALSLHDDQAELEVGQQLHALQQRLQIMENIITALNREVEKTQLTVVVLERDNHNNMNLIQHLEAVVAEQQQRLIRKDLQISSLQQSISAQ-QDVSYDGTFLWRICDVSQKLKEAATGQKSSQYSPAFYTSRYGFKVCMRLYM--YGDGVGKGTHISLFFVIMKGDYDPLLSWPFKQKVTFFLIDQNQRE-HVVDAFRPD----LRSASFQRPVSEM-NVASGCPLFFPLSKLRSPKHAYVKDDTLFIKCVVD 515          

HSP 2 Score: 55.8398 bits (133), Expect = 5.384e-8
Identity = 44/133 (33.08%), Postives = 61/133 (45.86%), Query Frame = 1
Query:   67 NKFDFVFDSNLSDDL-----LCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKF-CPKNIGNCKKLINFNRD----ITIDHF-----ANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGC 420
            N+F   F  ++ DDL     LCS C N+L+ A Q  CG RYC  C+   L  N+   C K    CK+      D    +T+DHF      NK+I  ++V C    C +  +L    DH      +C YA + C
Sbjct:    8 NEFPCGFPQSICDDLPPVHFLCSSCNNVLNEAHQTQCGHRYCRACVMWLLRNNKDLICTK----CKEDPGSESDSSMMLTLDHFFSDNAINKEIQELRVHCVNQGCGWRSTLKDFEDHQS----QCEYALIPC 132          
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 86.6557 bits (213), Expect = 6.331e-18
Identity = 96/435 (22.07%), Postives = 172/435 (39.54%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFC-----------------------------------------QFSDSLIVMAD----------HMKSH--------SIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP +       +     +  D+FA ++ILS+ V+C  + C                                         + S  LI   D           + SH         + C ++  GC E +M  +++  H+   T  H   + + +RN +  IN L    I +         ++    +          E++ +++ + EL++   +++  + E+  +N   S +   + K+L SLEE +   L   ++   + W++E  S  I   + G+    +S  FY+   GYK+  RL++  P   + + Y  L V+   + GE+D  L WP+   + + ++DQ  G  +V+       +      AF RP+ QR+P    Y
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVD-----NEVLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMELRHLENHIPHCKFATVPCPQCQESVWKSELEEHINQECSHRLITCPDCAENIIYAEKQLASHCDTDCLKAPVACTFSIFGCRE-KMLRNDLALHMQEFTQMHMRYMADVLRNQT--INGL----ISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEE-SMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVEVMETKPDLQ-----AFQRPTVQRNPKGFGY 470          
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf1 (TNF receptor-associated factor 1-like [Source:NCBI gene;Acc:103045252])

HSP 1 Score: 84.7297 bits (208), Expect = 2.744e-17
Identity = 74/343 (21.57%), Postives = 152/343 (44.31%), Query Frame = 1
Query:  397 CPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINM---------------------------------INIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSN---------------EQILIEKRLK--SLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYK--MRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            C ++E+GC   + +   +++H  + T +H +LL+E +RN+   +    E  ++   +  +LQ +++    +I +                                 ++ ++  ++ +++ +  L  + ++    +  + R N N               +Q LI K L+  SL++       +  +   F W+I ++SQ + ++  G +   YS +FY+   G+K  MRLY+  YG  + +  H+ ++FV++ G+YD +L WP  + VT  L+DQ     +V ++F+ +       A+F RP     +    C       K+       V D ++F+KC VD
Sbjct:  206 CVFSEIGCT-FKGNPDKVREHEVSSTSAHLHLLVEVVRNVQMSVPPPPERTVQYPALDLHLQNQDMTPLPDITLNGGELETDSGDTGANDKALSLHDDQAELEVGQQLHALQQRLQIMENIITALNREVEKTQLTVVVLERDNHNNMNLIQHLEAVVAEQQQRLIRKDLQISSLQQSISAQ-QDVSYDGTFLWRICDVSQKLKEAATGQKSSQYSPAFYTSRYGFKVCMRLYM--YGDGVGKGTHISLFFVIMKGDYDPLLSWPFKQKVTFFLIDQNQRE-HVVDAFRPD----LRSASFQRPVSEM-NVASGCPLFFPLSKLRSPKHAYVKDDTLFIKCVVD 538          

HSP 2 Score: 55.8398 bits (133), Expect = 4.560e-8
Identity = 44/133 (33.08%), Postives = 61/133 (45.86%), Query Frame = 1
Query:   67 NKFDFVFDSNLSDDL-----LCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKF-CPKNIGNCKKLINFNRD----ITIDHF-----ANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGC 420
            N+F   F  ++ DDL     LCS C N+L+ A Q  CG RYC  C+   L  N+   C K    CK+      D    +T+DHF      NK+I  ++V C    C +  +L    DH      +C YA + C
Sbjct:    8 NEFPCGFPQSICDDLPPVHFLCSSCNNVLNEAHQTQCGHRYCRACVMWLLRNNKDLICTK----CKEDPGSESDSSMMLTLDHFFSDNAINKEIQELRVHCVNQGCGWRSTLKDFEDHQS----QCEYALIPC 132          
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf5 (TNF receptor-associated factor 5 [Source:NCBI gene;Acc:103031120])

HSP 1 Score: 69.707 bits (169), Expect = 2.174e-12
Identity = 81/363 (22.31%), Postives = 150/363 (41.32%), Query Frame = 1
Query:  313 KVKCPELFCQFSDSLI--VMADHMKSHSIKCPYAEVGCI------ESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKEN-AIRNKEMIE-NLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKR--LKSLEEINEGNLTNTKFYAPFEWKIENISQLID----QSKLGNQRFTY----------------------------SQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            K  CPE   Q  +  I  V    +K H+ +CP  E  CI        R     +K H   E   H  LL+ES   L  +++ L+++ A +  E+ E NL + N  L+ E++  +     M+   +  +EL +  +++ K + +++  +  ++ L+  R  L SL E      +  +         ++ ++L+D    Q +   QRF                              S  FY+  +GYK+   +   G       HL +Y +++ G++D +L WP  + VT+ ++DQ     +V  SF  +     F+    RP+  +   + + + +         N   V D ++F+K  VD
Sbjct:  187 KTSCPEAEVQCPNKCIHLVKRHKLKDHADECPEQETDCIYKKYGCTVRNKRGQVKVHEQTEFNHHVLLLLESNSKLIKQVDQLQQDFAAQQGELKERNLLVSN--LKREVSKCDTTVSAMQRSVEEQRELVSSVKRELKDLRDVLEADLTKEELVSLRASLDSLREQVAMTQSLREHLGALGQTCQSHTRLLDIHVQQLQCSEQRFQQLESTSYDGKLIWKVHDYHRKKEAGTALNSPPFYTSHSGYKLSARVYLGGEGTARGTHLSLYVMLMRGDFDSLLPWPFRQNVTLAVLDQSGNRNHVSLSFTPDLASNNFR----RPTSETNAALGFPRFITHADLEAPRNAAYVRDDTLFIKVKVD 543          
BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Match: traf6 (TNF receptor associated factor 6 [Source:NCBI gene;Acc:103021325])

HSP 1 Score: 68.9366 bits (167), Expect = 3.345e-12
Identity = 66/283 (23.32%), Postives = 127/283 (44.88%), Query Frame = 1
Query:  364 MADHMKSHSIKCPYAEV----GCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKN---SNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYID-PYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            +A H  +  +K P A      GC E +M  +++  H+   T  H   + + +RN +  IN L    I +         ++    +          E++ +++ + EL++   +++  + E+  +N   S +   + K+L SLEE +   L   ++   + W++E  S  I   + G+    +S  FY+   GYK+  RL++  P   + + Y  L V+   + GE+D  L WP+   + + ++DQ  G  +V+       +      AF RP+ QR+P    Y
Sbjct:  227 LASHCDTDCLKAPVACTFSIFGCRE-KMLRNDLALHMQEFTQMHMRYMADVLRNQT--INGL----ISSHSASAASPTDSRGASSRPEGACQCNQELQQMRETVLELESRLVRQDHKLRELSIRNETQSTQMTELRKKLASLEE-SMRELQAQQYQGVYVWRLEGFSTHIRNQEAGHPVVLHSPPFYTGRPGYKLCLRLHLQTPNAPRCSNYISLFVH--TMQGEFDSQLSWPLQGTIRLAVLDQAEGQHHVEVMETKPDLQ-----AFQRPTVQRNPKGFGY 494          

HSP 2 Score: 52.7582 bits (125), Expect = 4.490e-7
Identity = 35/118 (29.66%), Postives = 53/118 (44.92%), Query Frame = 1
Query:   73 FDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIE 426
            +D  FD  L     C IC   L  A Q  CG R+C  CI K +    + CP +       +     +  D+FA ++ILS+ V+C  + C     L     H+++H   C +A V C +
Sbjct:   56 YDVDFDPPLESKYECPICLMGLRSAVQTPCGHRFCNCCIRKSIRDTGQKCPVD-----NEVLTEDQLFPDNFAKREILSLTVRCRNVGCMEKMEL----RHLENHIPHCKFATVPCPQ 164          
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002130.1 (pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 gene:ENSPMAG00000001936.1 transcript:ENSPMAT00000002130.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 82.0333 bits (201), Expect = 2.580e-17
Identity = 62/246 (25.20%), Postives = 112/246 (45.53%), Query Frame = 1
Query:  445 NIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQN---------EINMINIVKMEMKTLQDGMKELK----NDSQQKNKLIYEMMRKNSNEQIL--IEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            +I+DH TN +   T  + +  ++LS+       N  R    +E L   N +LQ+                ++ +M TL++ ++ L+    N    + +      R   ++ +L   E+RL+ LE           +     WKI + ++   ++  G     YSQ FY+   GYKM  R Y++  G  +    HL ++FVV+ GEYD +L+WP  + VT+ L+DQ     ++ ++F  +     F+
Sbjct:  140 SIEDH-TNMSEMLTQRVAQLEQDLSHWSTLTGSNNTRLGSTLEMLTQHNEQLQSLHVAQRAPQRDADTAALRRDMATLRERLRALEAALGNPGPCEERCHMHEQRLTMHDGLLDTAERRLQVLE--------TAGYSGKLVWKIRDYARRKQEAASGRTLSLYSQPFYTSPFGYKMCARAYLN--GDGVGRGTHLSLFFVVMRGEYDALLEWPFRRRVTLSLLDQGAARRHLSDTFTPDPASGSFR 374          
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000074.1 (pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-1 gene:ENSPMAG00000000066.1 transcript:ENSPMAT00000000074.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 73.1738 bits (178), Expect = 2.764e-14
Identity = 68/327 (20.80%), Postives = 123/327 (37.61%), Query Frame = 1
Query:  361 VMADHMKSHSIKCPYAEVGCIESRMDT------HNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEI------------------NMINIVKMEMKTLQDGMK---------ELKNDSQQKNKLIYEMMRK--------NSNEQILIEKRLKSLE--------------------EINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS 1152
            +  + + SH   CPY +  C  S+           +K+H +  T  H +L+     NL  +++ L+          + L     EL+ E+                   M+ +    +  LQ+ M+          L+ D       ++E+  +         S        RL +L+                    ++    L    +     WKI + ++    +  G     YSQ FY+   GY+M  R Y++  G  +    HL ++FVV+ GEYD +L WP  + VT+ L+DQ      + ++FK +       ++F RP+
Sbjct:  114 IAREELVSHLGICPYKQAECFFSQFGCKYKGTLQGLKEHESGATQQHLSLVTARSANLELKVSMLQSQLAERANSADLLGTRVRELEKELISVGQTASKNESVLCVVQRMLAVQTERLLRLQESMQGTTRRADHDALRGDLDGTAATLHELGTRVAAIEESGGSVTHSSTPTRLAALDSALSRHDTQLFAHDTRLAEMDLRFQVLETASYNGKLVWKIRDYARRKQDAVSGRTLSLYSQPFYTSPFGYRMCARAYLN--GDGVGRGTHLSLFFVVMRGEYDALLPWPFRQRVTLTLLDQGAARRQLSDTFKPDPAS----SSFRRPT 434          
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: traf6 (TNF receptor-associated factor 6 [Source:NCBI gene;Acc:554561])

HSP 1 Score: 62.003 bits (149), Expect = 1.342e-10
Identity = 81/385 (21.04%), Postives = 143/385 (37.14%), Query Frame = 1
Query:  175 CYHCIEKYL----NGNEKFCPKNIGNCKKLIN-FNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEI-----------NFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKL----IYEMMRKNSNEQILIE---KRLKSLE-EINEGNLTNTKFYAP-FEWKIENISQLI----------DQSKLGNQRFTYSQSFYSHVNGYKMRLYID-------PYGYQ------INEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQI-LGSIYVKESFKANSIDRYFKAAFDRPS-QRSPDDIDY 1179
            C HC EK        +E+ CP  + NCK       R+    H              E+ CQ +              + C ++ +GC E++M    +  H+   T  H  LL   ++ L  ++           +    N++          ++           +    +     D ++E+    +++  L    I E+  K  N+Q L+    + ++SLE  + E   + ++  A  F W++E  S+L+          D          +S  FY+ V GY++ L +        P G             HL ++  ++ G+YD  L WP    + I +VDQ    S++V E   A+       +AF RPS  R+P    Y
Sbjct:  186 CLHCCEKMAYKDSKNHEQMCPLVVVNCKHCQQELIREQLGPHL-------------EVDCQQAQ-------------VPCTFSPLGC-EAQMVRSLLAAHMHEHTQVHMRLLANGLKILRIQVGQGAQPSSAAGSSAPPNSLSWLSSTSGGDVQTAGASRSQGSRDRAACDCAQELDRLREITRTLEERVVLQLHQIRELSAKTDNQQGLLAEATRLVRSLEARVAE---SESRLCAGIFTWRVERFSRLLPGGLASGFASDGMHPDAPAVMHSSGFYTGVPGYRLCLRLQVLSGREVPAGAASPSVLLAGRQPHLALFVHLLQGDYDHRLPWPFKGRIRISVVDQCERDSVHVTEMMDADPQ----LSAFQRPSVHRNPKGFGY 536          

HSP 2 Score: 53.9138 bits (128), Expect = 4.683e-8
Identity = 37/141 (26.24%), Postives = 60/141 (42.55%), Query Frame = 1
Query:   19 FNEMSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCI--EKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRM 435
            F+ +SG   +++      ++  F+  L     C IC   L    Q  CG R+C  CI     L      CP +       +     +  D+FA ++ILS+ V+CP   C     L      ++ H ++C YA+V C+   M
Sbjct:   36 FHSVSG---DDSATEAQGYEADFEPPLESKYECPICLMALREPVQTPCGHRFCRACILHSMRLRDAGPKCPVD-----NAVLHEGQLFPDNFAKREILSLTVRCPNKPCGHRGELRA----LQEHQLRCEYAQVPCVRCEM 164          
BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008091.1 (pep scaffold:Pmarinus_7.0:GL477915:34322:50582:-1 gene:ENSPMAG00000007312.1 transcript:ENSPMAT00000008091.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 51.9878 bits (123), Expect = 1.459e-7
Identity = 45/224 (20.09%), Postives = 100/224 (44.64%), Query Frame = 1
Query:  397 CPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKE----MIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQ------ILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTY--SQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWP 1032
            CPY+ +GC+  R    ++ +H  N    H  ++ ++ +    ++     + I++      +    Q+  ++ + E  +   V+ +++  +   ++   D  +  +L  +M R   ++Q      + + +RL  LE        NT +   F WKI+++   + ++  G +R     S +F++   GY++RL +   G  ++ YA      ++  G YD  L WP
Sbjct:  187 CPYSPLGCL-YRGHGESLHNHDKNSVEVHLAIVYDAFKKTFEQLIKGHADNIKHPPSARLVAAEAQLATMDRRVE-EVAKRVERDVRVSEASTRQGNIDRDETARLQNKMARVEHSDQETERSILGLTRRLAELE--------NTAYNGMFLWKIKHVINRLREAGNGAERPPQIDSPAFFTTRYGYRLRLRLCRSGEHVSAYA------MLGPGPYDATLAWP 394          
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48773 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RI91])

HSP 1 Score: 84.7297 bits (208), Expect = 8.897e-18
Identity = 91/427 (21.31%), Postives = 162/427 (37.94%), Query Frame = 1
Query:   61 LLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKC---PELFCQFSDSLIVMADHMKSHSI------------------------KCPYAEVGCIESRMDT--HNIKDHLTNETYSHTNL----------------LIESIRNLSNEINFLK-------------ENAIRNKEMIENLQIENIELQNEINMINIVKMEMKT----LQDGMKELKNDSQQK-NKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPS 1152
            L   +D  FD  L     C IC   L    Q  CG R+C++CI + +      CP +           R++  D+FA ++++S  V C    E  C +  +L  + +H+K                             CP   V C   +M      I++HL       TN                   E+  N S   +  K             E+     E+      ++  +Q E++M+     E +     L+  ++++K  S ++  +L +++MR  + E  L            EG + N  F     WK++N  Q  + S  G     +S  FY+ + GYKM L ++  G       H+ ++  ++ G++D +L+WP    +T+ ++DQ    I  +       + +    AF RP+
Sbjct:   40 LEEGYDEFFDPPLESKYECPICLLGLRDPVQTPCGHRFCFNCIRRSIRDAGPKCPVD-----NTPLSERELYRDNFAKREMMSFIVWCRLKKERGCTWKGALKELEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPCDHCKMKVTISKIEEHLKGCPCMDTNCPNECGAVMQRKEVDKHCAEACPNRSVPCDHCKMKSSKEQASHGPQEHTPHEAELRREALFQSANMQREVDMLGSRGDEYRQFLAYLERKVEDVKTSSDRRIAELTHKLMRLETREIEL------------EGRVCNGTFI----WKLDNFRQCREGSIAGLTAAIHSPPFYTSMYGYKMCLRMNLNGVDGGLGEHVSLFIHMMQGDWDGILEWPFIGRITLSILDQS-DQIDSRRPISETLVAKPNLLAFQRPT 444          
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO48394 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RJK8])

HSP 1 Score: 79.7221 bits (195), Expect = 3.369e-16
Identity = 102/458 (22.27%), Postives = 178/458 (38.86%), Query Frame = 1
Query:   79 FVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKF-CPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSL----------------------------IVMADHMKS------------------------HSIKCP-------YAEVGCI----ESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMI----------NIVKMEMKTLQDGM--------KELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLT------------NTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYF-------KAAFDRP 1149
            F+   N  D+L+C+IC  +++      CG  YC +CIEK+ NG E   CP +    K        I  D   ++ +LS++VKC    C++   L                            I+M  H  +                        H   CP       ++E+GC     ES  D     +H  +   +H ++  E+IR+   +I+ L +   + ++    LQ ++ +   E+N I          N  ++E  + + G+        KE  +  +++  +  E +RKN ++   +    K+  +  +G                  F    E K  N     D S  G+     S  FY+   GYKMRL   P GY   +  HL +   ++ GEYD +L+WP  + +T+ L++Q        E +++ +++ Y        K  F+RP
Sbjct:   20 FIIPPN--DELICAICHMVVNEPVLTSCGHSYCKYCIEKWCNGKEVVTCPVDNEQLKP-----SQIFPDKKTDRIVLSLEVKCTNNPCRWKGELRQKQKHLKICSHKAVKCILEGCNVKVPRILMEKHTNTCGWRLLHCKPCNLSYPKKDEETVQHKDDCPLAFLPCRFSEIGCTFKGRESARD-----EHCESAVQTHLHIACETIRDNKEQISDLHKELDKVRQ---ELQTKSCDHMKEVNAIREKHDEAIRDNKGQIEALSKEHGIASNTIHENKEQLDTLKKELGIASETIRKNRDQIAKLSTACKT--QYTDGTFVWRICNYKDKYKKAVAFATNQEVKGGNSDSDDDISMAGD--IMVSLPFYTSRYGYKMRLKAYPNGYGDGKGTHLSLSIRIMKGEYDAILEWPFRRKITLSLINQ-------SEQWRSETVEIYPDDATPDKKHKFERP 451          
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO38873 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SBN4])

HSP 1 Score: 79.7221 bits (195), Expect = 3.370e-16
Identity = 88/414 (21.26%), Postives = 158/414 (38.16%), Query Frame = 1
Query:   88 DSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKV-------KCP-----------------------------------------------ELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKE-----------------NAIRNKEMIENL----------QIENIELQNEINMINIVKME--MKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            D+ ++   LC+ C+ I+  A Q  CG RYC  CI   L+     C        K   F      D FA+++IL + V        CP                                               E  C + +  +V+A   + H   CP   V C +   +   ++ H T  T       +E  R   N +  L++                 N +++  + EN+          ++ N+E +   + + +V+    +  L+  +  L    Q+ + +I  + R+          R  ++ ++ E    L  T F +   WKI N++    ++  G     YS  F++  +GYKM  R+Y++  G   N   H+ ++FV++ GE+D +L WP  + VT+ L+DQ
Sbjct:   15 DTAIAAKHLCAKCRLIVKDAVQTACGHRYCSPCISPLLSRGPIQCDVCGSTITKPETFR-----DKFADREILELHVHCVNQPHGCPWEGELRHRQNHHTKCEFNPISCVHPECGKKLSVAKLPEHLQNECQYREETCSYCEQPVVVARMKEHHEKTCPSYPVNCPKCSKELIRVEVHSTPFTREPR---LEKGRGCENTLEVLEDHESRIKKLEQRGGGIGVNGLQSMRISENIDNEAIGDVLRRVANVEAKGADHEVLVVEAHSAVDELRREVGRLNVKLQESDDIIRRLERQLELHDQGTGLRNLAIADLEERLNTLQGTTFDSVLLWKITNVANKRSEATSGRVTSFYSPCFFTGPHGYKMCARIYLNGDGMGRNH--HVSLFFVIMRGEFDALLRWPFRQKVTLMLLDQ 418          
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO31690 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX76])

HSP 1 Score: 78.1814 bits (191), Expect = 9.225e-16
Identity = 82/365 (22.47%), Postives = 150/365 (41.10%), Query Frame = 1
Query:   22 NEMSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKF-CPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCI----ESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIE------NLQIENIELQNEINMINIVK----MEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSL-EEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            N   GFN E+           F++  S +L+C IC  +++      CG  +C  C  K+ NG +   CP +     K +  N+    D    +++LS+ VKC    C +   L       K H  KC +  + C+    ++R+  ++++ H     +         +     E   +K        ++           E  +  +  +  N V+    M   T++D  KE++ ++++        +R N+ E   + K L +  + I E      K    F W+I +   L  +         YS SFY+   GYK++L  +      N   HL +Y  ++ GEYD +L+WP  + +T+ ++DQ
Sbjct:    7 NTGEGFNPEQ-----------FETPPSPELMCGICLMVVNKPVLTYCGHSFCNFCFNKWRNGKDVVTCPVDY----KQLETNQ-FMADKKTERQVLSLCVKCMNGPCSWKGEL----RDKKKHLTKCGHEVIKCVFDGCDTRLARNSMEKHEETCEWKIVTCEFCDVPYPKREEETVKHRGDCPLAILPCKFSDIGCTFEGRQHAHVAHCENAVQAHLDMACGTIRDNNKEIRKNNKK--------IRGNNKEIETLHKELNTANQTIRELKGKMAKLIGTFVWRICDYKDLYGE--------IYSPSFYTSKYGYKVQLKANLRTNPFNGGTHLSLYACIMVGEYDALLEWPFRRKITLYVIDQ 335          
BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Match: EDO40665 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6K0])

HSP 1 Score: 76.6406 bits (187), Expect = 2.662e-15
Identity = 75/307 (24.43%), Postives = 128/307 (41.69%), Query Frame = 1
Query:  160 CGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPY-AEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNE-INFLKENAIRNKEMIENLQIE-NIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTY-SQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            CG R+C  C+E  L     FCP +    ++ I+ ++ +  D    + +LS+ VKCP                  +H   C +  E+G         N+  + +N       + IE+ + +  + +N      I  +EM  ++ ++ +  L       + V  + K  +  M++   DS              ++   +   R++ LE+  E   TN KF     WKI N +QL  QS    ++    S  FY+   GYK+R      G    +  HL +Y V++ G+YD VL WP  + V   L+DQ
Sbjct:   58 CGHRFCESCLEPILRKPPAFCPID----RRCISRDK-VYPDKACKRTVLSLTVKCP------------------NHVTDCEWVGELG---------NLPSNSSNSYEVLVKVHIEACKRVPIKCVNNCGRTDIAREEMAVHIDVDGDCPLATVPCKYSDVGCKTKVKRIEMEKHLQDSM-------------ASHLDMAHIRIRELEQRQEKICTNGKFL----WKISNYTQLFQQSATKKEKEKLCSPPFYTGQYGYKLRAEAFLNGLGQGKGTHLSLYVVIMKGDYDSVLPWPFQQRVDFILIDQ 315          
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf3 (TNF receptor associated factor 3 [Source:NCBI gene;Acc:101161601])

HSP 1 Score: 94.7449 bits (234), Expect = 9.072e-21
Identity = 90/370 (24.32%), Postives = 163/370 (44.05%), Query Frame = 1
Query:  115 CSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELF--CQFSDSLIVMADHMKSHSIKCPYAEVGC----IESRMDTHNIKDHLT-------------------NETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQ---DGMKELKNDSQQKNKLIYEMMRKNSNEQILI-EKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFK 1131
            C  C+ +L    Q  CG R+CY CI   L+     CP ++        F   I  D   +++I+++KV C      CQ   SL  + DH+      CP+ EV C     + RM    I +HL                     E   H   +  +   +S   +    +  R+++++ +   + +EL+ E+  +  ++ EM++L+   D ++   +  +Q  +   E      ++ + + E RL  ++ +    L    +     WKI +  +    +  G     YSQ FY+   GYKM  R+Y++  G  + +  HL ++FVV+ GEYD +L WP  + VT+ L+DQ     ++ ++FK +     F+
Sbjct:   48 CEACRLVLCQPRQTECGHRFCYSCINDILSCPNPVCPADMEPL-----FKDKIFRDVCCHREIMALKVYCRSEANGCQEQMSLQQIPDHVNV----CPFFEVPCPLGKCKERMMRKEIPEHLAWKCKYRESTCEFCKNKMPLTELQKHKETVCPAF-PVSCPNHCTSSSLPRSEKLMSSHTEKLLELELELRSLRQLRDEMESLRGTLDTVRTRLSALEQGGRASLETQLNRHDDMLSVHEIRLADMD-LRFQVLETASYNGTLIWKIRDYKRRKQDAVAGKTLSLYSQPFYTGYFGYKMCARVYLN--GDGMGKGTHLSLFFVVMRGEYDALLPWPFKQKVTLMLMDQGPSRKHLGDAFKPDPSSSSFR 404          
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 75.0998 bits (183), Expect = 3.440e-14
Identity = 68/257 (26.46%), Postives = 120/257 (46.69%), Query Frame = 1
Query:  370 DHMKSHS---IKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLS------------NEINFLKENAIRNKEMIENLQIENIELQNEINMI-NIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLK----SLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            DH KS +     CP++EVGC +S ++   I +H  + T  H  LL+  + +++             E + L      +        + +++L  +++ + NIV +  + ++     L+  S Q ++L  E +   SN+   +E+ L      L E  +    L    +   F WKI + S    ++  G     +S +FYS   GYKM  RLY++  G       HL ++FVV+  +YD +L WP ++ VT+ L+DQ
Sbjct:  207 DHAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCVLNREVERSSLTLEAFSHQ-HRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLN--GDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 459          
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf2b (TNF receptor associated factor 2 [Source:NCBI gene;Acc:101159764])

HSP 1 Score: 75.0998 bits (183), Expect = 3.514e-14
Identity = 68/257 (26.46%), Postives = 120/257 (46.69%), Query Frame = 1
Query:  370 DHMKSHS---IKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLS------------NEINFLKENAIRNKEMIENLQIENIELQNEINMI-NIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLK----SLEEINE--GNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM--RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQ 1068
            DH KS +     CP++EVGC +S ++   I +H  + T  H  LL+  + +++             E + L      +        + +++L  +++ + NIV +  + ++     L+  S Q ++L  E +   SN+   +E+ L      L E  +    L    +   F WKI + S    ++  G     +S +FYS   GYKM  RLY++  G       HL ++FVV+  +YD +L WP ++ VT+ L+DQ
Sbjct:  200 DHAKSCAKSKSACPFSEVGC-KSVVENGKISEHEHSSTMEHLRLLLPMVLSMTRTRLDTSPSGEWQEDSGLGLYRAPDDGCGAAASVPSVDLDKKVSALENIVCVLNREVERSSLTLEAFSHQ-HRLDQEKIENLSNKIRQLERSLTVKDLQLSEAEQMVRELQYCTYDGIFVWKITDFSHRRQEAVSGRAPAMFSPAFYSSKYGYKMCLRLYLN--GDGTGRGTHLSLFFVVMRSKYDALLKWPFSQKVTLMLLDQ 452          
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: ENSORLT00000001369.2 (TNF receptor-associated factor 5 [Source:NCBI gene;Acc:101170323])

HSP 1 Score: 68.5514 bits (166), Expect = 4.284e-12
Identity = 97/511 (18.98%), Postives = 181/511 (35.42%), Query Frame = 1
Query:   43 DEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNG---NEKFCP----------------------------KNIGNCKKLINFN--------------------------RDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIES--------RMDTHN-------------------------IKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMI--------NIVKMEMKTL---QDGMKELKNDSQQ----KNKLIYEMMR-KNSNEQILIE------------------KRLKSLEEINEGNLT----------NTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDI 1173
            + E  +L +   FV    L ++ +C ICK ++    QN CG  YC+HC++  L     +   CP                             N   C  ++  N                          R +  +H  N      +  CP     F   L V+ DH++S    CP  +VGC +         R+  H                          +K H       H  L+++S  +L  ++ F+++ A+  ++ ++   +   +LQ ++  +        +IV    +TL   +D +  ++ D QQ        + E+ R K S + ++ E                  KR   L E++   L            T +     WKI++  +  +    G      S  F++   GYKM +     G       HL +Y V++ G++D +L WP  + V++ ++DQ     +   +F+ +  +      F +P+  S  ++
Sbjct:   46 ESELASLQHSLKFVM--KLKEEFICPICKGVVLNPQQNSCGHIYCFHCLQGLLESSLLSGPVCPVEKAAITPSEVFQDNCCKREISSLEVYCTNSPLCTSVLALNQLQEHLKSCQYEQLLCSNPGCTELLQRRLLQEHL-NATCPHRRESCPHCLQPF--QLSVIQDHVQS---SCPEVKVGCPDGCSTLVPRNRLTEHGESCPEVHTDCSFKMFGCSVKGKRRKVKLHEEAAVCHHVLLVLKSSAHLEQQVVFVQKEALLRQQEVQTDTLLLSDLQEQLGSVLQQSRSQEHIVATAQRTLSRQEDALSSVQLDLQQVSCGMGSGLDELRRFKTSLDGVMQELLAAETLREHIATLEENRKRHSGLLELHVAQLALNKQHLQELELTSYDGRLIWKIKDFQKRREAEATGQHPCLSSVPFHTGRCGYKMAMKAYLNGDGEGRGTHLSLYVVLMPGDFDALLPWPFKQTVSLSVLDQSGARNHQSFNFRPDPTN----TCFHQPAAESASNV 544          
BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Match: traf4a (TNF receptor associated factor 4 [Source:NCBI gene;Acc:101161428])

HSP 1 Score: 67.0106 bits (162), Expect = 1.376e-11
Identity = 38/154 (24.68%), Postives = 80/154 (51.95%), Query Frame = 1
Query:  664 KELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSI----YVKESFKANS 1113
            + L++ ++    ++  ++ +   E + + + ++ L   ++G L          WK+ + S+ + ++KL +    +S  FY+H  GYK+++     G    E +HL VY  V+ GEYD++L+WP +  VT  ++DQ   S+    ++ E+F  + 
Sbjct:  261 RHLEDTTKSHLTMMCNLVSRQRQEILELRREMEELSVSHDGVLI---------WKLNDYSRKLQEAKLRSNHEFFSPPFYTHRYGYKLQVSAFLNGNGSGEGSHLSVYIRVLPGEYDNLLEWPFSYKVTFSILDQSDPSLSKPQHITETFNPDP 405          
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070155.1 (SMESG000070155.1)

HSP 1 Score: 813.527 bits (2100), Expect = 0.000e+0
Identity = 414/414 (100.00%), Postives = 414/414 (100.00%), Query Frame = 1
Query:   28 MSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXXXXXXXMDGSIFLKCFVD 1269
            MSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSVLINLKVLLNNPKLVMDGSIFLKCFVD
Sbjct:    1 MSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINIVKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSVLINLKVLLNNPKLVMDGSIFLKCFVD 414          
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070236.1 (SMESG000070236.1)

HSP 1 Score: 277.33 bits (708), Expect = 4.843e-89
Identity = 152/392 (38.78%), Postives = 231/392 (58.93%), Query Frame = 1
Query:   46 EEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCK-KLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQ--IENIELQN--EINM----INIVKMEMKTLQDGMKELKNDSQQKNK--LIYEMMRKNS--------NEQILIEKRLKSLEEINEGN-LTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRS 1161
            +E + LL  +DF  D+ L  DL+C+IC+ IL+   Q+ CGCRYCY CIEK+L    K+CPK   +C+ + ++ N ++  DHFANK +L+IKVKCPE  C     L  + +H+KSHSI CP+ E+GC  S + +  +  H+T E+YSHT LL+ESI+N+ NEI  L+EN  R ++ I  LQ  + N  LQ+  EI +    I+++K   K  +    EL  DS Q N+   I +   + S        +      +R + +   +    ++  +  APFEWKIE+    + ++K    +  YS+ FYSH NGYK+RL ++P G+   E  HL V+F ++ GE+DD L WPM + V IGLVDQ+   I V + ++  S+++ F+  F +PS R+
Sbjct:    7 QEIYQLLTDYDFQVDTFLYSDLICTICEKILNRPYQSPCGCRYCYSCIEKHLKSGNKYCPKPTDDCREQCVDINNNLQFDHFANKNVLAIKVKCPEKACDTKAELKNLMEHLKSHSINCPFHEMGCSHSNVKSQAMVQHMTEESYSHTILLMESIQNMKNEIEILRENLQRKEKTIGKLQNQLRNNTLQHNKEIAIMKKDISLLKNVSKIEKGTTAELPTDSIQINQDGTICDFTEEESVHYTESETDSHFSGTRRSRFMSATSSLRCISANEDIAPFEWKIEDFMNRVQEAKSKLSKVIYSKPFYSHRNGYKLRLRVNPNGFGKWENTHLSVFFSIIEGEFDDSLFWPMERQVVIGLVDQVSNKIQVSDKYRWKSVEKDFQVIFHKPSTRT 398          
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070096.1 (SMESG000070096.1)

HSP 1 Score: 238.81 bits (608), Expect = 5.979e-74
Identity = 157/447 (35.12%), Postives = 240/447 (53.69%), Query Frame = 1
Query:   46 EEAWNLLNKFDFVFDSNLS-DDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCK-KLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMIN----------IVKMEMKTLQDG---------MKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGN---------------LTNTKFY-APFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXX--XXXXXMDGSIFLKCFVD 1269
            EE WNL NK++F  + N    DL C +C+ +L  ASQ+ CGCRYC+ CI  YL   EK CP    +CK + IN ++DITIDH AN+KI  + VKCPE  C     L  M +H+ SH + CPY ++GC         + DH+ +   SH +LLI+ + N+ N+I +LK +   +    EN+   N +  ++IN I           I K++ +T Q G         ++E+ ++   + K++   M +  NE  L+  ++    +I+  +               L   K + APFEWKI N  +  +++  G +   YS+ FYSH NGYK++L IDP G +  +  +L V F ++ GEYDD LDWPM K V I L++Q  G +++ + +K +S+ +  K  F +P  R  DD DY    L  +K  +   N K+ ++ SI LKCF+D
Sbjct:    6 EEMWNLFNKYNFKLNLNSKFADLKCCVCQGLLRNASQSPCGCRYCHSCIVVYLGDEEKCCPGPHDDCKYQRINIHKDITIDHAANRKISMVDVKCPEESCNARIQLRQMPEHITSHILSCPYLDIGCNIKLRGVCELVDHMLDADQSHASLLIQCLNNIKNDIEYLKGSDSASFSSSENINAINYDAISQINNIKLSTLPQISQKISKLKSETAQRGNDIGRLESQIEEVNSNCMSEIKILTLEMERLRNE--LVAYKIGKDLDISTTDSMLSSADSNSTSSFILKQVKEHIAPFEWKITNFMEKHERAISGEKLTVYSEPFYSHKNGYKIQLRIDPNGDEAVKALYLSVSFGIIGGEYDDELDWPMTKQVKISLINQKTGLVHISKRYKFDSVLKKSKCIFFKPISRFEDDEDYFFGTLKFIKFSVLFNNQKIFLNDSIVLKCFID 450          
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000070096.1 (SMESG000070096.1)

HSP 1 Score: 238.81 bits (608), Expect = 6.077e-74
Identity = 157/447 (35.12%), Postives = 240/447 (53.69%), Query Frame = 1
Query:   46 EEAWNLLNKFDFVFDSNLS-DDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCK-KLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMIN----------IVKMEMKTLQDG---------MKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEINEGN---------------LTNTKFY-APFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSXXXXXXXXXX--XXXXXMDGSIFLKCFVD 1269
            EE WNL NK++F  + N    DL C +C+ +L  ASQ+ CGCRYC+ CI  YL   EK CP    +CK + IN ++DITIDH AN+KI  + VKCPE  C     L  M +H+ SH + CPY ++GC         + DH+ +   SH +LLI+ + N+ N+I +LK +   +    EN+   N +  ++IN I           I K++ +T Q G         ++E+ ++   + K++   M +  NE  L+  ++    +I+  +               L   K + APFEWKI N  +  +++  G +   YS+ FYSH NGYK++L IDP G +  +  +L V F ++ GEYDD LDWPM K V I L++Q  G +++ + +K +S+ +  K  F +P  R  DD DY    L  +K  +   N K+ ++ SI LKCF+D
Sbjct:    5 EEMWNLFNKYNFKLNLNSKFADLKCCVCQGLLRNASQSPCGCRYCHSCIVVYLGDEEKCCPGPHDDCKYQRINIHKDITIDHAANRKISMVDVKCPEESCNARIQLRQMPEHITSHILSCPYLDIGCNIKLRGVCELVDHMLDADQSHASLLIQCLNNIKNDIEYLKGSDSASFSSSENINAINYDAISQINNIKLSTLPQISQKISKLKSETAQRGNDIGRLESQIEEVNSNCMSEIKILTLEMERLRNE--LVAYKIGKDLDISTTDSMLSSADSNSTSSFILKQVKEHIAPFEWKITNFMEKHERAISGEKLTVYSEPFYSHKNGYKIQLRIDPNGDEAVKALYLSVSFGIIGGEYDDELDWPMTKQVKISLINQKTGLVHISKRYKFDSVLKKSKCIFFKPISRFEDDEDYFFGTLKFIKFSVLFNNQKIFLNDSIVLKCFID 449          
BLAST of TNF receptor-associated factor vs. Planmine SMEST
Match: SMESG000067208.1 (SMESG000067208.1)

HSP 1 Score: 236.113 bits (601), Expect = 5.445e-73
Identity = 150/392 (38.27%), Postives = 217/392 (55.36%), Query Frame = 1
Query:   55 WNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYCYHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCPELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETYSHTNLLIESIRNLSNEINFLKENAIRNKE-------MIENLQI------ENIE-LQNEINMINIV----KMEMKTLQDGMKELKNDSQQKNKL--IYEMMR-----KNSNEQILIEKRLKSLEEINEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKMRLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILGSIYVKESFKANSI-----DRYFKAAF 1140
            W+LL K++F        DL+C ICK +L  A Q+ CGCRYCY CIEKYL   +K CP     C + +    DI +DH AN KI    VKCP+  CQF D L  M  H+KSH IKCPY E+GC +  ++  +I +HL  E  +H NLLI+SI+N+ N+I  L+E +++  E       ++E+++I      E IE L+ EIN   IV    K E+  L + +K  K   +++N++  + E  +     K S +  +     K + E+   N+ N   Y+PF WKIEN S   + +K     F  S +FYSHVNGYK+ L I P G  +++   L V F ++  E+D  L WPM   +TIGLV+Q    I+  E++  NS+     DR+F+  F
Sbjct:    9 WDLLVKYNFEVTGKNYRDLICVICKRLLINAHQSCCGCRYCYKCIEKYLEDKKKLCPGKGEGCNEQLISLFDIQVDHVANVKISKATVKCPDTICQFKDELRKMESHIKSHQIKCPYFEIGCSKVDINNADINNHLNIEHGNHANLLIDSIQNMRNDIATLREESLKKDEVLSLTQKLLEDMKIAHNRNEEVIETLKREINGNQIVAKNLKSEVANLNNELKNFKKTYKKENQIKSMNESQKSMNGNKGSPKTKVTINSPKPILELT--NVINGVKYSPFIWKIENFSDKKNTAKNVCDSFILSDTFYSHVNGYKICLTIFPDGSNVSQNDWLSVGFHLMKSEHDKDLFWPMAMNITIGLVNQKTNQIHASETYNVNSVTDINRDRFFRPVF 398          
The following BLAST results are available for this feature:
BLAST of TNF receptor-associated factor vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
TRAF31.042e-1622.41TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF32.057e-1523.01TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF32.057e-1523.01TNF receptor associated factor 3 [Source:HGNC Symb... [more]
TRAF12.385e-1523.83TNF receptor associated factor 1 [Source:HGNC Symb... [more]
TRAF12.385e-1523.83TNF receptor associated factor 1 [Source:HGNC Symb... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
trf-15.424e-1222.73TNF Receptor Associated Factor (TRAF) homolog; TRF... [more]
trf-23.143e-934.09TNF Receptor Associated Factor (TRAF) homolog [So... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3
Match NameE-valueIdentityDescription
Traf67.106e-1420.18gene:FBgn0265464 transcript:FBtr0071188[more]
Traf43.825e-824.54gene:FBgn0026319 transcript:FBtr0334401[more]
Traf44.543e-824.54gene:FBgn0026319 transcript:FBtr0077429[more]
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BLAST of TNF receptor-associated factor vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf68.801e-1620.57TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf68.801e-1620.57TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf68.801e-1620.57TNF receptor-associated factor 6 [Source:NCBI gene... [more]
traf37.413e-1523.53TNF receptor-associated factor 3 [Source:ZFIN;Acc:... [more]
unm_sa8081.429e-1324.44un-named sa808 [Source:ZFIN;Acc:ZDB-GENE-120727-21... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ssh21.186e-1622.60slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
TRAF28.212e-1624.29TNF receptor associated factor 2 [Source:NCBI gene... [more]
TRAF24.358e-1523.41TNF receptor associated factor 2 [Source:NCBI gene... [more]
ssh21.619e-1424.24slingshot protein phosphatase 2 [Source:Xenbase;Ac... [more]
egf1.887e-1321.43epidermal growth factor [Source:Xenbase;Acc:XB-GEN... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Traf36.286e-1621.38TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf36.286e-1621.38TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf31.036e-1423.05TNF receptor-associated factor 3 [Source:MGI Symbo... [more]
Traf22.367e-1424.90TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
Traf22.525e-1424.90TNF receptor-associated factor 2 [Source:MGI Symbo... [more]
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BLAST of TNF receptor-associated factor vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q6IWL4|TRAF6_DANRE6.643e-1520.57TNF receptor-associated factor 6 OS=Danio rerio OX... [more]
sp|Q13077|TRAF1_HUMAN1.145e-1423.83TNF receptor-associated factor 1 OS=Homo sapiens O... [more]
sp|B5DF45|TRAF6_RAT2.234e-1422.32TNF receptor-associated factor 6 OS=Rattus norvegi... [more]
sp|B6CJY4|TRAF6_CERAT6.730e-1421.43TNF receptor-associated factor 6 OS=Cercocebus aty... [more]
sp|B6CJY5|TRAF6_MACMU7.165e-1421.43TNF receptor-associated factor 6 OS=Macaca mulatta... [more]
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BLAST of TNF receptor-associated factor vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
T1E1014.491e-3429.91TRAF-6 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
I1ZID85.805e-2532.65TNF receptor associated factor-2 (Fragment) OS=Sch... [more]
T1DBK61.262e-2427.68TRAF-4 OS=Dendrocoelum lacteum OX=27895 PE=2 SV=1[more]
A0A2B4SJ651.523e-2425.00TNF receptor-associated factor 4 OS=Stylophora pis... [more]
A0A5A9NXF13.719e-2424.71TNF receptor-associated factor OS=Triplophysa tibe... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf13.011e-1822.73TNF receptor-associated factor 1-like [Source:NCBI... [more]
traf66.331e-1822.07TNF receptor associated factor 6 [Source:NCBI gene... [more]
traf12.744e-1721.57TNF receptor-associated factor 1-like [Source:NCBI... [more]
traf52.174e-1222.31TNF receptor-associated factor 5 [Source:NCBI gene... [more]
traf63.345e-1223.32TNF receptor associated factor 6 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ENSPMAT00000002130.12.580e-1725.20pep scaffold:Pmarinus_7.0:GL484662:8457:12718:-1 g... [more]
ENSPMAT00000000074.12.764e-1420.80pep scaffold:Pmarinus_7.0:GL482142:165593:173010:-... [more]
traf61.342e-1021.04TNF receptor-associated factor 6 [Source:NCBI gene... [more]
ENSPMAT00000008091.11.459e-720.09pep scaffold:Pmarinus_7.0:GL477915:34322:50582:-1 ... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of TNF receptor-associated factor vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO487738.897e-1821.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO483943.369e-1622.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO388733.370e-1621.26Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316909.225e-1622.47Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO406652.662e-1524.43Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of TNF receptor-associated factor vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
traf39.072e-2124.32TNF receptor associated factor 3 [Source:NCBI gene... [more]
traf2b3.440e-1426.46TNF receptor associated factor 2 [Source:NCBI gene... [more]
traf2b3.514e-1426.46TNF receptor associated factor 2 [Source:NCBI gene... [more]
ENSORLT00000001369.24.284e-1218.98TNF receptor-associated factor 5 [Source:NCBI gene... [more]
traf4a1.376e-1124.68TNF receptor associated factor 4 [Source:NCBI gene... [more]
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BLAST of TNF receptor-associated factor vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000070155.10.000e+0100.00SMESG000070155.1[more]
SMESG000070236.14.843e-8938.78SMESG000070236.1[more]
SMESG000070096.15.979e-7435.12SMESG000070096.1[more]
SMESG000070096.16.077e-7435.12SMESG000070096.1[more]
SMESG000067208.15.445e-7338.27SMESG000067208.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020033 ID=SMED30020033|Name=TNF receptor-associated factor|organism=Schmidtea mediterranea sexual|type=transcript|length=1293bp
ATATAAATCTTATATGTTTTTAATGAAATGTCGGGATTTAATGATGAAGA
AGCCTGGAATTTGTTGAATAAATTCGATTTTGTTTTCGATAGCAATTTGA
GTGATGATCTCCTTTGCAGTATTTGTAAGAATATATTACACATTGCTTCT
CAAAACATTTGTGGTTGTCGGTATTGTTATCATTGCATTGAAAAGTATCT
CAATGGTAATGAGAAATTCTGTCCAAAAAATATTGGCAATTGCAAAAAGT
TAATAAACTTTAACAGGGATATAACTATCGATCATTTTGCCAATAAAAAA
ATATTATCAATTAAAGTTAAATGTCCTGAATTATTTTGTCAGTTTAGTGA
TTCCTTGATAGTTATGGCAGATCATATGAAATCTCATTCAATCAAATGTC
CATATGCTGAAGTTGGATGTATCGAATCTAGAATGGATACTCACAATATC
AAAGATCATTTAACTAACGAAACTTATTCCCACACAAATTTATTGATAGA
ATCTATACGCAATTTGAGCAACGAAATAAATTTCCTTAAAGAAAATGCAA
TAAGAAATAAAGAAATGATTGAAAATTTACAAATAGAAAACATCGAGTTG
CAAAATGAAATTAATATGATAAATATCGTTAAAATGGAAATGAAAACATT
ACAAGATGGAATGAAAGAATTGAAAAATGATTCACAACAGAAAAATAAAT
TAATTTATGAAATGATGCGGAAAAATTCCAACGAGCAAATTCTCATTGAA
AAACGATTGAAAAGCTTAGAGGAAATAAATGAAGGAAATTTAACAAATAC
GAAATTTTATGCGCCTTTCGAGTGGAAAATTGAGAATATTTCCCAACTTA
TCGATCAGTCGAAGCTGGGAAATCAAAGATTCACATACAGCCAATCGTTT
TATTCCCATGTAAATGGCTACAAGATGCGACTGTATATCGATCCCTATGG
TTACCAGATCAATGAATATGCTCATCTCGTTGTATATTTTGTTGTCGTCA
ATGGAGAATACGATGACGTTTTGGATTGGCCAATGAATAAGTTGGTAACA
ATCGGATTGGTTGATCAAATTTTAGGATCAATTTATGTCAAAGAATCGTT
CAAGGCCAATTCGATCGATCGATATTTCAAGGCCGCATTTGACAGGCCAT
CACAAAGGTCACCGGATGATATCGATTATTGCCAATCGGTGCTCATCAAT
TTGAAAGTGCTGCTGAATAATCCTAAACTAGTCATGGACGGATCGATTTT
TTTGAAATGTTTTGTTGATTGAAATAAAAATATTTATTGATTT
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protein sequence of SMED30020033-orf-1

>SMED30020033-orf-1 ID=SMED30020033-orf-1|Name=SMED30020033-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=415bp
MSGFNDEEAWNLLNKFDFVFDSNLSDDLLCSICKNILHIASQNICGCRYC
YHCIEKYLNGNEKFCPKNIGNCKKLINFNRDITIDHFANKKILSIKVKCP
ELFCQFSDSLIVMADHMKSHSIKCPYAEVGCIESRMDTHNIKDHLTNETY
SHTNLLIESIRNLSNEINFLKENAIRNKEMIENLQIENIELQNEINMINI
VKMEMKTLQDGMKELKNDSQQKNKLIYEMMRKNSNEQILIEKRLKSLEEI
NEGNLTNTKFYAPFEWKIENISQLIDQSKLGNQRFTYSQSFYSHVNGYKM
RLYIDPYGYQINEYAHLVVYFVVVNGEYDDVLDWPMNKLVTIGLVDQILG
SIYVKESFKANSIDRYFKAAFDRPSQRSPDDIDYCQSVLINLKVLLNNPK
LVMDGSIFLKCFVD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005164tumor necrosis factor receptor binding
GO:0005515protein binding
GO:0008270zinc ion binding
GO:0004842ubiquitin-protein transferase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005737cytoplasm
Vocabulary: biological process
TermDefinition
GO:0042981regulation of apoptotic process
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0006955immune response
GO:0007165signal transduction
GO:0016567protein ubiquitination
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
Vocabulary: INTERPRO
TermDefinition
IPR043211TNF_rcpt-assoc_TRAF
IPR013083Znf_RING/FYVE/PHD
IPR008974TRAF-like
IPR001841Znf_RING
IPR002083MATH/TRAF_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 157..229
NoneNo IPR availablePANTHERPTHR10131:SF129TNF RECEPTOR-ASSOCIATED FACTOR 6coord: 119..417
coord: 17..122
NoneNo IPR availableCDDcd16449RING-HCcoord: 34..70
e-value: 4.59664E-6
score: 41.2989
NoneNo IPR availableSUPERFAMILYSSF57850RING/U-boxcoord: 27..103
IPR013083Zinc finger, RING/FYVE/PHD-typeGENE3DG3DSA:3.30.40.10coord: 16..141
e-value: 4.5E-14
score: 54.4
IPR008974TRAF-likeGENE3DG3DSA:2.60.210.10coord: 203..418
e-value: 1.5E-33
score: 118.0
IPR008974TRAF-likeSUPERFAMILYSSF49599TRAF domain-likecoord: 268..418
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 17..122
IPR043211TNF receptor-associated factor TRAFPANTHERPTHR10131TNF RECEPTOR ASSOCIATED FACTORcoord: 119..417
IPR002083MATH/TRAF domainPROSITEPS50144MATHcoord: 265..417
score: 11.493
IPR001841Zinc finger, RING-typePROSITEPS50089ZF_RING_2coord: 34..70
score: 8.683