ETS homologous factor isoform X2

Overview
NameETS homologous factor isoform X2
Smed IDSMED30020022
Length (bp)1049
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of ETS homologous factor isoform X2 (SMED30020022) t-SNE clustered cells

Violin plots show distribution of expression levels for ETS homologous factor isoform X2 (SMED30020022) in cells (dots) of each of the 12 neoblast clusters.

 

back to top


 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of ETS homologous factor isoform X2 (SMED30020022) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for ETS homologous factor isoform X2 (SMED30020022) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top


 

Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020




SMED30020022

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
parenchymaSMED30020022h1SMcG0016105 dd_Smed_v4_7247_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior sideSMED30020022h1SMcG0016105 dd_Smed_v4_7247_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
posterior muscle cellSMED30020022h1SMcG0016105 dd_Smed_v4_7247_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30020022h1SMcG0016105 dd_Smed_v4_7247_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Match: ELF5 (E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320])

HSP 1 Score: 50.447 bits (119), Expect = 5.971e-7
Identity = 28/92 (30.43%), Postives = 47/92 (51.09%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E K
Sbjct:   70 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEDK 159          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Match: ELF5 (E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320])

HSP 1 Score: 50.0618 bits (118), Expect = 9.505e-7
Identity = 28/92 (30.43%), Postives = 47/92 (51.09%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E K
Sbjct:   97 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEDK 186          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Match: ELF5 (E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320])

HSP 1 Score: 49.6766 bits (117), Expect = 3.015e-6
Identity = 28/92 (30.43%), Postives = 47/92 (51.09%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E K
Sbjct:  185 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEDK 274          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Match: ELF5 (E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320])

HSP 1 Score: 49.2914 bits (116), Expect = 3.812e-6
Identity = 28/92 (30.43%), Postives = 47/92 (51.09%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E K
Sbjct:  175 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEDK 264          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Match: ELF5 (E74 like ETS transcription factor 5 [Source:HGNC Symbol;Acc:HGNC:3320])

HSP 1 Score: 49.2914 bits (116), Expect = 3.887e-6
Identity = 29/102 (28.43%), Postives = 48/102 (47.06%), Query Frame = 2
Query:  638 HRDAPRNQIGLLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            H         L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E K
Sbjct:  155 HSRTSLQSSHLWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEDK 254          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Match: ets-4 (Transcription factor ets-4 [Source:UniProtKB/Swiss-Prot;Acc:A8WFJ9])

HSP 1 Score: 54.6842 bits (130), Expect = 4.313e-8
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2
Query:  662 IGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + L  FI +LL+ P  Y  C+RWVD+    FKI +S L+A YW   K     N +  +R +R   + G  ++  KK +  Y+F
Sbjct:  288 VHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKF 370          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Match: ets-4 (Transcription factor ets-4 [Source:UniProtKB/Swiss-Prot;Acc:A8WFJ9])

HSP 1 Score: 54.6842 bits (130), Expect = 4.313e-8
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2
Query:  662 IGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + L  FI +LL+ P  Y  C+RWVD+    FKI +S L+A YW   K     N +  +R +R   + G  ++  KK +  Y+F
Sbjct:  288 VHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKF 370          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Match: ets-4 (Transcription factor ets-4 [Source:UniProtKB/Swiss-Prot;Acc:A8WFJ9])

HSP 1 Score: 54.6842 bits (130), Expect = 4.313e-8
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2
Query:  662 IGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + L  FI +LL+ P  Y  C+RWVD+    FKI +S L+A YW   K     N +  +R +R   + G  ++  KK +  Y+F
Sbjct:  288 VHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKF 370          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Match: ets-4 (Transcription factor ets-4 [Source:UniProtKB/Swiss-Prot;Acc:A8WFJ9])

HSP 1 Score: 54.6842 bits (130), Expect = 4.767e-8
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2
Query:  662 IGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + L  FI +LL+ P  Y  C+RWVD+    FKI +S L+A YW   K     N +  +R +R   + G  ++  KK +  Y+F
Sbjct:  349 VHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKF 431          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Match: F19F10.1 (pep chromosome:WBcel235:V:7562738:7564245:1 gene:WBGene00017598.1 transcript:F19F10.1.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:F19F10.1)

HSP 1 Score: 48.521 bits (114), Expect = 1.503e-6
Identity = 27/89 (30.34%), Postives = 40/89 (44.94%), Query Frame = 2
Query:  641 RDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            R +P  ++ LL F+ DLL        I W DK   +FK+     VA  W     N   N +  +RG+RY       +++  K  R Y+F
Sbjct:    5 RSSPTGKLRLLSFLRDLLEDESNSDIIYWFDKSESVFKMSKPHKVAELWGAATGNPGMNYDKMSRGLRYFYTNNTLEKVPGKDAR-YRF 92          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Fly
Match: Ets98B (gene:FBgn0005659 transcript:FBtr0085224)

HSP 1 Score: 51.2174 bits (121), Expect = 7.405e-7
Identity = 29/85 (34.12%), Postives = 41/85 (48.24%), Query Frame = 2
Query:  656 NQIGLLIFILDLLNHPYYKG-CIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + I L  F+ +LL  P   G  IRW+D+   IFKI +S  VA  W   K     N +  +R IR   + G  K+  +  +  YQF
Sbjct:  428 SHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQF 512          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Fly
Match: Ets98B (gene:FBgn0005659 transcript:FBtr0339318)

HSP 1 Score: 51.2174 bits (121), Expect = 8.120e-7
Identity = 29/85 (34.12%), Postives = 41/85 (48.24%), Query Frame = 2
Query:  656 NQIGLLIFILDLLNHPYYKG-CIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + I L  F+ +LL  P   G  IRW+D+   IFKI +S  VA  W   K     N +  +R IR   + G  K+  +  +  YQF
Sbjct:  414 SHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQF 498          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Zebrafish
Match: SPDEF (SAM pointed domain containing ETS transcription factor [Source:NCBI gene;Acc:100003543])

HSP 1 Score: 49.2914 bits (116), Expect = 2.871e-6
Identity = 29/83 (34.94%), Postives = 43/83 (51.81%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPY-YKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            I L  F+ +LL  P+ Y  CIRW++K   IFKI +S  VA  W + K     N +  +R IR   + G  ++ +   +  YQF
Sbjct:  239 IHLWQFLRELLLKPHSYGRCIRWLNKEKGIFKIEDSAHVARLWGLRKNRPAMNYDKLSRSIRQYYKKGIIRKPDVSQRLVYQF 321          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Zebrafish
Match: elf3 (E74-like factor 3 (ets domain transcription factor, epithelial-specific ) [Source:ZFIN;Acc:ZDB-GENE-030131-8760])

HSP 1 Score: 49.6766 bits (117), Expect = 2.922e-6
Identity = 32/112 (28.57%), Postives = 56/112 (50.00%), Query Frame = 2
Query:  602 KCRNVSEFVSF----RHRDAPRNQIGLLIFILDLLNHPYY-KGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAI 922
            K R+   F  F    + + APR    L  FI D+L HP   +G ++W D+   +FK + S+ VA  W   K+N +   E  +R +RY  +    ++++ + +  Y+F K + 
Sbjct:  257 KLRDSDGFDHFIQSKKSKHAPRG-THLWEFIRDILIHPEQNQGLMKWEDRRDGVFKFLKSEAVAQLWGQKKKNSSMTYEKLSRAMRYYYKREILERVDGR-RLVYKFGKNST 366          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Zebrafish
Match: elf3 (E74-like factor 3 (ets domain transcription factor, epithelial-specific ) [Source:ZFIN;Acc:ZDB-GENE-030131-8760])

HSP 1 Score: 49.2914 bits (116), Expect = 3.778e-6
Identity = 32/112 (28.57%), Postives = 56/112 (50.00%), Query Frame = 2
Query:  602 KCRNVSEFVSF----RHRDAPRNQIGLLIFILDLLNHPYY-KGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAI 922
            K R+   F  F    + + APR    L  FI D+L HP   +G ++W D+   +FK + S+ VA  W   K+N +   E  +R +RY  +    ++++ + +  Y+F K + 
Sbjct:  299 KLRDSDGFDHFIQSKKSKHAPRG-THLWEFIRDILIHPEQNQGLMKWEDRRDGVFKFLKSEAVAQLWGQKKKNSSMTYEKLSRAMRYYYKREILERVDGR-RLVYKFGKNST 408          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Xenopus
Match: ELF5 (E74 like ETS transcription factor 5 [Source:NCBI gene;Acc:100494059])

HSP 1 Score: 48.521 bits (114), Expect = 4.123e-6
Identity = 27/94 (28.72%), Postives = 49/94 (52.13%), Query Frame = 2
Query:  641 RDAPRNQIGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKA 919
            R A  +   L  F+ DLL  P    G + W DK   +F+++ S+ +A  W   K+N+  N E  +R +R+  + G  ++++++    Y+F K A
Sbjct:  119 RPAAVHSSHLWEFMRDLLLSPDANDGILEWDDKEQGVFRVVKSEALAQMWGKRKKNERMNYEKLSRALRHYYKTGILERVDRRL--VYKFGKNA 210          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Xenopus
Match: ELF5 (E74 like ETS transcription factor 5 [Source:NCBI gene;Acc:100494059])

HSP 1 Score: 48.521 bits (114), Expect = 4.444e-6
Identity = 27/94 (28.72%), Postives = 49/94 (52.13%), Query Frame = 2
Query:  641 RDAPRNQIGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKA 919
            R A  +   L  F+ DLL  P    G + W DK   +F+++ S+ +A  W   K+N+  N E  +R +R+  + G  ++++++    Y+F K A
Sbjct:  120 RPAAVHSSHLWEFMRDLLLSPDANDGILEWDDKEQGVFRVVKSEALAQMWGKRKKNERMNYEKLSRALRHYYKTGILERVDRRL--VYKFGKNA 211          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Xenopus
Match: ELF5 (E74 like ETS transcription factor 5 [Source:NCBI gene;Acc:100494059])

HSP 1 Score: 48.521 bits (114), Expect = 6.113e-6
Identity = 25/85 (29.41%), Postives = 46/85 (54.12%), Query Frame = 2
Query:  668 LLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKA 919
            L  F+ DLL  P    G + W DK   +F+++ S+ +A  W   K+N+  N E  +R +R+  + G  ++++++    Y+F K A
Sbjct:  161 LWEFMRDLLLSPDANDGILEWDDKEQGVFRVVKSEALAQMWGKRKKNERMNYEKLSRALRHYYKTGILERVDRRL--VYKFGKNA 243          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Xenopus
Match: ENSXETT00000020719.1 (E74 like ETS transcription factor 3 [Source:NCBI gene;Acc:100144720])

HSP 1 Score: 48.9062 bits (115), Expect = 7.186e-6
Identity = 26/85 (30.59%), Postives = 46/85 (54.12%), Query Frame = 2
Query:  668 LLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKA 919
            L  FI D+L HP   +G ++W D+   +FK + S+ VA  W   K+N +   E  +R +RY  +    ++++ + +  Y+F K A
Sbjct:  284 LWEFIRDILLHPDLNQGLLKWEDRSEGVFKFLRSEAVAQLWGQKKKNSSMTYEKLSRAMRYYYKREILERVDGR-RLVYKFGKNA 367          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Mouse
Match: Elf5 (E74-like factor 5 [Source:MGI Symbol;Acc:MGI:1335079])

HSP 1 Score: 50.0618 bits (118), Expect = 1.577e-6
Identity = 28/92 (30.43%), Postives = 48/92 (52.17%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E+K
Sbjct:  182 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEEK 271          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Mouse
Match: Elf5 (E74-like factor 5 [Source:MGI Symbol;Acc:MGI:1335079])

HSP 1 Score: 49.6766 bits (117), Expect = 1.808e-6
Identity = 28/92 (30.43%), Postives = 48/92 (52.17%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E+K
Sbjct:  163 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEEK 252          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Mouse
Match: Elf5 (E74-like factor 5 [Source:MGI Symbol;Acc:MGI:1335079])

HSP 1 Score: 49.6766 bits (117), Expect = 1.808e-6
Identity = 28/92 (30.43%), Postives = 48/92 (52.17%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E+K
Sbjct:  163 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEEK 252          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Mouse
Match: Elf5 (E74-like factor 5 [Source:MGI Symbol;Acc:MGI:1335079])

HSP 1 Score: 49.6766 bits (117), Expect = 1.808e-6
Identity = 28/92 (30.43%), Postives = 48/92 (52.17%), Query Frame = 2
Query:  668 LLIFILDLLNHPYYK-GCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKK 940
            L  F+ DLL  P    G + W D+   IF+++ S+ +A  W   K+ND    E  +R +RY  + G  ++++++    Y+F K A    E+K
Sbjct:  163 LWEFVRDLLLSPEENCGILEWEDREQGIFRVVKSEALAKMWGQRKKNDRMTYEKLSRALRYYYKTGILERVDRRL--VYKFGKNAHGWQEEK 252          
BLAST of ETS homologous factor isoform X2 vs. UniProt/SwissProt
Match: sp|A8WFJ9|ETS4_CAEEL (Transcription factor ets-4 OS=Caenorhabditis elegans OX=6239 GN=ets-4 PE=1 SV=1)

HSP 1 Score: 54.6842 bits (130), Expect = 6.064e-7
Identity = 29/83 (34.94%), Postives = 44/83 (53.01%), Query Frame = 2
Query:  662 IGLLIFILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + L  FI +LL+ P  Y  C+RWVD+    FKI +S L+A YW   K     N +  +R +R   + G  ++  KK +  Y+F
Sbjct:  349 VHLWQFIRELLDQPKQYSACVRWVDRDEGTFKIESSLLLARYWGQRKNRSQMNYDKLSRSLRQYYKKGIIQKPEKKQRLVYKF 431          
BLAST of ETS homologous factor isoform X2 vs. UniProt/SwissProt
Match: sp|P29775|ETS4_DROME (DNA-binding protein D-ETS-4 OS=Drosophila melanogaster OX=7227 GN=Ets98B PE=2 SV=3)

HSP 1 Score: 51.2174 bits (121), Expect = 7.423e-6
Identity = 29/85 (34.12%), Postives = 41/85 (48.24%), Query Frame = 2
Query:  656 NQIGLLIFILDLLNHPYYKG-CIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            + I L  F+ +LL  P   G  IRW+D+   IFKI +S  VA  W   K     N +  +R IR   + G  K+  +  +  YQF
Sbjct:  428 SHIHLWQFLKELLASPQVNGTAIRWIDRSKGIFKIEDSVRVAKLWGRRKNRPAMNYDKLSRSIRQYYKKGIMKKTERSQRLVYQF 512          
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Match: A0A1I8GPB9 (ETS domain-containing protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 1.588e-9
Identity = 33/83 (39.76%), Postives = 54/83 (65.06%), Query Frame = 2
Query:  677 FILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVG-FFKQINKKAQRTYQFNKKAI 922
            F+L LLN+P     IRW+D+ + +FK+++   VA  W  +K N T N E FARGIR+ R +G +F+    + ++ Y+F++KA+
Sbjct:  240 FLLKLLNNPSCSSLIRWLDRENRLFKVLHPVTVARLWQFIKGNRTDNYECFARGIRHSRDIGKYFEAHEFRKKKVYKFSEKAL 322          
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Match: A0A267GQD5 (ETS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006668g3 PE=3 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 1.916e-9
Identity = 33/83 (39.76%), Postives = 54/83 (65.06%), Query Frame = 2
Query:  677 FILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVG-FFKQINKKAQRTYQFNKKAI 922
            F+L LLN+P     IRW+D+ + +FK+++   VA  W  +K N T N E FARGIR+ R +G +F+    + ++ Y+F++KA+
Sbjct:  240 FLLKLLNNPSCSSLIRWLDRENRLFKVLHPVTVARLWQFIKGNRTDNYECFARGIRHSRDIGKYFEAHEFRKKKVYKFSEKAL 322          
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Match: A0A1I8FYC8 (ETS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006668g1 PE=3 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 1.975e-9
Identity = 33/85 (38.82%), Postives = 55/85 (64.71%), Query Frame = 2
Query:  677 FILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVG-FFKQINKKAQRTYQFNKKAIKE 928
            F+L LLN+P     IRW+D+ + +FK+++   VA  W  +K N T N E FARGIR+ R +G +F+    + ++ Y+F++KA+ +
Sbjct:  241 FLLKLLNNPSCSSLIRWLDRENRLFKVLHPVTVARLWQFIKGNRTDNYECFARGIRHSRDIGKYFEAHEFRKKKVYKFSEKALNQ 325          
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Match: A0A267F0N9 (ETS domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006668g2 PE=3 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 2.080e-9
Identity = 33/83 (39.76%), Postives = 54/83 (65.06%), Query Frame = 2
Query:  677 FILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVG-FFKQINKKAQRTYQFNKKAI 922
            F+L LLN+P     IRW+D+ + +FK+++   VA  W  +K N T N E FARGIR+ R +G +F+    + ++ Y+F++KA+
Sbjct:  240 FLLKLLNNPSCSSLIRWLDRENRLFKVLHPVTVARLWQFIKGNRTDNYECFARGIRHSRDIGKYFEAHEFRKKKVYKFSEKAL 322          
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Match: A0A267FM46 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig022108g1 PE=3 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 6.105e-9
Identity = 33/87 (37.93%), Postives = 55/87 (63.22%), Query Frame = 2
Query:  674 IFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVG-FFKQINKKAQRTYQFNKKAIKEY 931
            +F+L LL++   +  I WVDK + +FK++    +A  W  +K N T N E FARGIR+ R +G +F+    + ++ Y+F+ KAI++Y
Sbjct:  597 LFLLKLLDNSRCRANIEWVDKYNRLFKVVTPSAIAKLWKHIKGNKTDNYECFARGIRHSRDIGRYFEPHGFRQKKIYKFSPKAIEDY 683          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Match: spi1b (Spi-1 proto-oncogene [Source:NCBI gene;Acc:103033056])

HSP 1 Score: 50.447 bits (119), Expect = 8.523e-7
Identity = 45/177 (25.42%), Postives = 80/177 (45.20%), Query Frame = 2
Query:  428 MENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCR--NVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVD--KGSLIFKIINSKLVAYYWMVVKEN-DTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            ++  + G  L      V  +P P+     ++ P+++  +       V +   LE   ++C   ++S      H +  + +I L  F+LDLL +   K  I WVD  KG+  F   + + +A+ W V K N      +  AR +R   + G  K+I KK   TYQF+ + + +   +R
Sbjct:   93 LDPGLTGPHLALSPQQVTYLPRPVCYPHMQQSPLMRSSDDDDP---VSRSPPLEVSDEECMRDHISSTTGVEHGN--KKKIRLYQFLLDLLRNGDMKDSIWWVDREKGTFQFSSKHKEALAHRWGVQKGNRKKMTYQKMARALRNYGKTGEVKKIKKKL--TYQFSGEVLGKSHLER 262          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Match: spi1b (Spi-1 proto-oncogene [Source:NCBI gene;Acc:103033056])

HSP 1 Score: 50.447 bits (119), Expect = 1.037e-6
Identity = 45/177 (25.42%), Postives = 80/177 (45.20%), Query Frame = 2
Query:  428 MENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCR--NVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVD--KGSLIFKIINSKLVAYYWMVVKEN-DTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            ++  + G  L      V  +P P+     ++ P+++  +       V +   LE   ++C   ++S      H +  + +I L  F+LDLL +   K  I WVD  KG+  F   + + +A+ W V K N      +  AR +R   + G  K+I KK   TYQF+ + + +   +R
Sbjct:  118 LDPGLTGPHLALSPQQVTYLPRPVCYPHMQQSPLMRSSDDDDP---VSRSPPLEVSDEECMRDHISSTTGVEHGN--KKKIRLYQFLLDLLRNGDMKDSIWWVDREKGTFQFSSKHKEALAHRWGVQKGNRKKMTYQKMARALRNYGKTGEVKKIKKKL--TYQFSGEVLGKSHLER 287          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Match: spi1b (Spi-1 proto-oncogene [Source:NCBI gene;Acc:103033056])

HSP 1 Score: 50.0618 bits (118), Expect = 1.134e-6
Identity = 45/177 (25.42%), Postives = 80/177 (45.20%), Query Frame = 2
Query:  428 MENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCR--NVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVD--KGSLIFKIINSKLVAYYWMVVKEN-DTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            ++  + G  L      V  +P P+     ++ P+++  +       V +   LE   ++C   ++S      H +  + +I L  F+LDLL +   K  I WVD  KG+  F   + + +A+ W V K N      +  AR +R   + G  K+I KK   TYQF+ + + +   +R
Sbjct:   64 LDPGLTGPHLALSPQQVTYLPRPVCYPHMQQSPLMRSSDDDDP---VSRSPPLEVSDEECMRDHISSTTGVEHGN--KKKIRLYQFLLDLLRNGDMKDSIWWVDREKGTFQFSSKHKEALAHRWGVQKGNRKKMTYQKMARALRNYGKTGEVKKIKKKL--TYQFSGEVLGKSHLER 233          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Match: SPDEF (SAM pointed domain containing ETS transcription factor [Source:NCBI gene;Acc:103037006])

HSP 1 Score: 49.2914 bits (116), Expect = 2.855e-6
Identity = 29/83 (34.94%), Postives = 43/83 (51.81%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPY-YKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            I L  F+ +LL  P+ Y  CIRW++K   IFKI +S  VA  W + K     N +  +R IR   + G  ++ +   +  YQF
Sbjct:  253 IHLWQFLRELLLKPHSYGRCIRWLNKEKGIFKIEDSAHVARLWGLRKNRPAMNYDKLSRSIRQYYKKGIIRKPDVSQRLVYQF 335          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Match: SPDEF (SAM pointed domain containing ETS transcription factor [Source:NCBI gene;Acc:103037006])

HSP 1 Score: 49.2914 bits (116), Expect = 2.855e-6
Identity = 29/83 (34.94%), Postives = 43/83 (51.81%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPY-YKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            I L  F+ +LL  P+ Y  CIRW++K   IFKI +S  VA  W + K     N +  +R IR   + G  ++ +   +  YQF
Sbjct:  253 IHLWQFLRELLLKPHSYGRCIRWLNKEKGIFKIEDSAHVARLWGLRKNRPAMNYDKLSRSIRQYYKKGIIRKPDVSQRLVYQF 335          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Nematostella
Match: EDO45361 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RSZ8])

HSP 1 Score: 45.4394 bits (106), Expect = 1.746e-6
Identity = 31/88 (35.23%), Postives = 43/88 (48.86%), Query Frame = 2
Query:  653 RNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQR-TYQFNK 913
            +N I L  F+L+LL    Y   I W  K    FK+ N + VA  W ++K     N E  +R IRY  + G  K++    QR  Y+F K
Sbjct:   10 KNTIHLWEFLLELLADERYSSLIAWSRKEYGEFKLKNQEEVAKRWGILKHRAGMNYEKLSRAIRYYYQQGIIKKV--PGQRLVYKFGK 95          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Nematostella
Match: EDO44339 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RW27])

HSP 1 Score: 45.0542 bits (105), Expect = 1.808e-6
Identity = 26/82 (31.71%), Postives = 43/82 (52.44%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            I L  F+LDLL    Y   I W ++ S  FK++N + VA  W  +K     N +  +R +RY  + G  K+++ + +  Y+F
Sbjct:    3 IHLWEFLLDLLADGRYSSIISWTNRESGEFKLLNQEEVARRWGHLKHRPGMNYDKLSRALRYYYQKGIIKKVHGQ-RLVYKF 83          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Nematostella
Match: EDO28913 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T551])

HSP 1 Score: 44.669 bits (104), Expect = 2.581e-6
Identity = 24/72 (33.33%), Postives = 37/72 (51.39%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQI 877
            I L  F+LDLL    Y   I W ++ S  FK++N + VA  W  +K     N +  +R +RY  + G  K++
Sbjct:    3 IHLWEFLLDLLADGRYSSIISWTNRESGEFKLLNQEEVARRWGHLKHRPGMNYDKLSRALRYYYQKGIIKKV 74          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Nematostella
Match: EDO49261 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGZ4])

HSP 1 Score: 43.1282 bits (100), Expect = 7.993e-6
Identity = 24/57 (42.11%), Postives = 31/57 (54.39%), Query Frame = 2
Query:  677 FILDLLNHP-YYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIR 844
            F+++LL+ P  Y   I WVD+   IFK INS  VA  W   +       ENFAR +R
Sbjct:    9 FLIELLSKPERYSHLIEWVDEEKGIFKFINSTKVAREWGERRNKPFMKYENFARSLR 65          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Medaka
Match: elf3 (ETS-related transcription factor Elf-3 [Source:NCBI gene;Acc:101162593])

HSP 1 Score: 50.447 bits (119), Expect = 1.476e-6
Identity = 29/99 (29.29%), Postives = 54/99 (54.55%), Query Frame = 2
Query:  626 VSFRHRDAPRNQIGLLIFILDLLNHPYY-KGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKA 919
            +S +++ APR    L  FI D+L HP   +G ++W D+   +FK + S+ VA  W   K+N +   E  +R +RY  +    ++++ + +  Y+F K +
Sbjct:  336 ISKKNKHAPRG-THLWEFIRDILIHPEKNQGLMKWEDRREGVFKFLKSEAVAQMWGQKKKNSSMTYEKLSRAMRYYYKREILERVDGR-RLVYKFGKNS 432          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Medaka
Match: SPDEF (SAM pointed domain containing ETS transcription factor [Source:NCBI gene;Acc:101167865])

HSP 1 Score: 49.2914 bits (116), Expect = 3.236e-6
Identity = 29/83 (34.94%), Postives = 43/83 (51.81%), Query Frame = 2
Query:  662 IGLLIFILDLLNHPY-YKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQF 907
            I L  F+ +LL  P+ Y  CIRW++K   IFKI +S  VA  W + K     N +  +R IR   + G  ++ +   +  YQF
Sbjct:  246 IHLWQFLRELLLKPHNYGRCIRWLNKEKGIFKIEDSAHVARLWGLRKNRPAMNYDKLSRSIRQYYKKGIIRKPDVSQRLVYQF 328          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Medaka
Match: ENSORLT00000007127.2 (transcription factor PU.1 [Source:NCBI gene;Acc:101163896])

HSP 1 Score: 47.3654 bits (111), Expect = 7.554e-6
Identity = 33/105 (31.43%), Postives = 53/105 (50.48%), Query Frame = 2
Query:  626 VSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWV--DKGSLIFKIINSKLVAYYWMVVKEN-DTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEY 931
             SFR +D  + +I L  F+LDLL +      I WV  DKG   F   + + +A +W + K N      +  AR +R   + G  K++ KK   TYQF++  ++ +
Sbjct:  141 TSFR-KDTNKRKIRLYQFLLDLLKNGLMSDSIWWVDQDKGIFQFSTKHKEALATHWGLQKGNRKKMTYQKMARALRNYGKTGEIKKVKKKL--TYQFSEDVLRNF 242          
BLAST of ETS homologous factor isoform X2 vs. Ensembl Medaka
Match: ENSORLT00000040237.1 (transcription factor PU.1 [Source:NCBI gene;Acc:101163896])

HSP 1 Score: 47.3654 bits (111), Expect = 8.135e-6
Identity = 33/105 (31.43%), Postives = 53/105 (50.48%), Query Frame = 2
Query:  626 VSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWV--DKGSLIFKIINSKLVAYYWMVVKEN-DTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEY 931
             SFR +D  + +I L  F+LDLL +      I WV  DKG   F   + + +A +W + K N      +  AR +R   + G  K++ KK   TYQF++  ++ +
Sbjct:  144 TSFR-KDTNKRKIRLYQFLLDLLKNGLMSDSIWWVDQDKGIFQFSTKHKEALATHWGLQKGNRKKMTYQKMARALRNYGKTGEIKKVKKKL--TYQFSEDVLRNF 245          
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Match: SMESG000069597.1 (SMESG000069597.1)

HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0
Identity = 274/275 (99.64%), Postives = 274/275 (99.64%), Query Frame = 2
Query:  119 MIFNDIFFGDIDCTENVIGSNNEISDEDSLPQDFNLEETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            MIFNDIFFGDIDCTENVIGSNNEISDEDSLPQDFNLEETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCN ENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR
Sbjct:    1 MIFNDIFFGDIDCTENVIGSNNEISDEDSLPQDFNLEETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNFENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 275          
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Match: SMESG000069596.1 (SMESG000069596.1)

HSP 1 Score: 296.975 bits (759), Expect = 2.484e-99
Identity = 156/301 (51.83%), Postives = 204/301 (67.77%), Query Frame = 2
Query:  113 NDMIFNDIFFG-----DIDCTENVIGSNNEISDE------------------DSLPQDFNLE-ETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            +D+IFNDIF G     D +   ++I +N+E   E                    L  + NLE + L++  +   D +  + +  IQ +F+N +K+ EL  + +TF+EKYF  Y CP D I++++R+QLWM+NCIYGLQLQ YICMV D P+P V  RNRK PI + K+ T  +KG+  D +LEYL   C++ S   + R RDAPRNQIG+L FILDLLNHPY++ CI+W DK SL FKIINSKLVAYYWM+VKENDTC+ ENFARGIRYLR  G+FKQI+ K QRTYQFNKK+I+ Y+ KR
Sbjct:    8 HDIIFNDIFCGNCEEVDWEDLSDLIIANSECYHELEINSNYDIFQNSQNSSSSGLEVESNLENDMLLESINSYRDGMWSDSTSSIQKDFINLVKNYELKEFNKTFVEKYFILYNCPLDDILKKSRSQLWMDNCIYGLQLQVYICMVNDYPIPTVQHRNRKVPI-QSKSGTSKKKGIVCDRLLEYLQSNCKSDSRVANVRPRDAPRNQIGMLTFILDLLNHPYFEPCIKWEDKKSLTFKIINSKLVAYYWMIVKENDTCSFENFARGIRYLRHWGYFKQIDMKKQRTYQFNKKSIQTYKSKR 307          
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Match: SMESG000069596.1 (SMESG000069596.1)

HSP 1 Score: 291.582 bits (745), Expect = 3.689e-98
Identity = 139/236 (58.90%), Postives = 178/236 (75.42%), Query Frame = 2
Query:  236 LIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKKNLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            L++  +   D +  + +  IQ +F+N +K+ EL  + +TF+EKYF  Y CP D I++++R+QLWM+NCIYGLQLQ YICMV D P+P V  RNRK PI + K+ T  +KG+  D +LEYL   C++ S   + R RDAPRNQIG+L FILDLLNHPY++ CI+W DK SL FKIINSKLVAYYWM+VKENDTC+ ENFARGIRYLR  G+FKQI+ K QRTYQFNKK+I+ Y+ KR
Sbjct:    2 LLESINSYRDGMWSDSTSSIQKDFINLVKNYELKEFNKTFVEKYFILYNCPLDDILKKSRSQLWMDNCIYGLQLQVYICMVNDYPIPTVQHRNRKVPI-QSKSGTSKKKGIVCDRLLEYLQSNCKSDSRVANVRPRDAPRNQIGMLTFILDLLNHPYFEPCIKWEDKKSLTFKIINSKLVAYYWMIVKENDTCSFENFARGIRYLRHWGYFKQIDMKKQRTYQFNKKSIQTYKSKR 236          
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Match: SMESG000035130.1 (SMESG000035130.1)

HSP 1 Score: 157.147 bits (396), Expect = 2.903e-45
Identity = 102/278 (36.69%), Postives = 156/278 (56.12%), Query Frame = 2
Query:  128 NDIFFGD-IDCTENVIGSNNEISDEDSLPQDFNLEETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYF--TSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKK-NLTQARKGVF-QDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRR-VGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            +D+F+GD     E    S   ++ +D   +D N  E+  D ++ C++   P     I + F+ +M S+E   + ETF  KYF  + +    + ++   R   W  +  YGL  QA+I    ++ LP + +RNRK PI+ +K   +   KG + +D + + L + C+ ++E   ++ R +PR+Q+ L IFILDLL HPYY  CI W +K    F+I NS+ VA+ WM +K NDTCN ENFARGIR+ RR    F + NK  +  YQ  K AI +Y+ KR
Sbjct:   13 SDLFYGDDYSEVEEFFYSKILVAYDD---EDENYLESF-DMSNDCMELCRPLIDSSILSKFIRYMCSKENEFFSETFCHKYFKRSRFSEYPEELINLNRVDAWNIDWAYGLVYQAFIAQEYNLELPCLKKRNRKIPIIGEKLKRSYKSKGYYDKDPIYDELIKNCK-LTEKEDYK-RKSPRDQVLLHIFILDLLMHPYYGFCITWSNKNDFTFEIKNSRAVAHIWMTIKGNDTCNYENFARGIRFKRRNSNMFTRTNKHNRCVYQLTKTAIHDYKVKR 284          
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Match: SMESG000035130.1 (SMESG000035130.1)

HSP 1 Score: 156.762 bits (395), Expect = 4.596e-45
Identity = 102/278 (36.69%), Postives = 156/278 (56.12%), Query Frame = 2
Query:  128 NDIFFGD-IDCTENVIGSNNEISDEDSLPQDFNLEETLIDETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYF--TSYKCPTDHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKK-NLTQARKGVF-QDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDLLNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGIRYLRR-VGFFKQINKKAQRTYQFNKKAIKEYEKKR 943
            +D+F+GD     E    S   ++ +D   +D N  E+  D ++ C++   P     I + F+ +M S+E   + ETF  KYF  + +    + ++   R   W  +  YGL  QA+I    ++ LP + +RNRK PI+ +K   +   KG + +D + + L + C+ ++E   ++ R +PR+Q+ L IFILDLL HPYY  CI W +K    F+I NS+ VA+ WM +K NDTCN ENFARGIR+ RR    F + NK  +  YQ  K AI +Y+ KR
Sbjct:   19 SDLFYGDDYSEVEEFFYSKILVAYDD---EDENYLESF-DMSNDCMELCRPLIDSSILSKFIRYMCSKENEFFSETFCHKYFKRSRFSEYPEELINLNRVDAWNIDWAYGLVYQAFIAQEYNLELPCLKKRNRKIPIIGEKLKRSYKSKGYYDKDPIYDELIKNCK-LTEKEDYK-RKSPRDQVLLHIFILDLLMHPYYGFCITWSNKNDFTFEIKNSRAVAHIWMTIKGNDTCNYENFARGIRFKRRNSNMFTRTNKHNRCVYQLTKTAIHDYKVKR 290          
The following BLAST results are available for this feature:
BLAST of ETS homologous factor isoform X2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ELF55.971e-730.43E74 like ETS transcription factor 5 [Source:HGNC S... [more]
ELF59.505e-730.43E74 like ETS transcription factor 5 [Source:HGNC S... [more]
ELF53.015e-630.43E74 like ETS transcription factor 5 [Source:HGNC S... [more]
ELF53.812e-630.43E74 like ETS transcription factor 5 [Source:HGNC S... [more]
ELF53.887e-628.43E74 like ETS transcription factor 5 [Source:HGNC S... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ets-44.313e-834.94Transcription factor ets-4 [Source:UniProtKB/Swis... [more]
ets-44.313e-834.94Transcription factor ets-4 [Source:UniProtKB/Swis... [more]
ets-44.313e-834.94Transcription factor ets-4 [Source:UniProtKB/Swis... [more]
ets-44.767e-834.94Transcription factor ets-4 [Source:UniProtKB/Swis... [more]
F19F10.11.503e-630.34pep chromosome:WBcel235:V:7562738:7564245:1 gene:W... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Ets98B7.405e-734.12gene:FBgn0005659 transcript:FBtr0085224[more]
Ets98B8.120e-734.12gene:FBgn0005659 transcript:FBtr0339318[more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
SPDEF2.871e-634.94SAM pointed domain containing ETS transcription fa... [more]
elf32.922e-628.57E74-like factor 3 (ets domain transcription factor... [more]
elf33.778e-628.57E74-like factor 3 (ets domain transcription factor... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 4
Match NameE-valueIdentityDescription
ELF54.123e-628.72E74 like ETS transcription factor 5 [Source:NCBI g... [more]
ELF54.444e-628.72E74 like ETS transcription factor 5 [Source:NCBI g... [more]
ELF56.113e-629.41E74 like ETS transcription factor 5 [Source:NCBI g... [more]
ENSXETT00000020719.17.186e-630.59E74 like ETS transcription factor 3 [Source:NCBI g... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 4
Match NameE-valueIdentityDescription
Elf51.577e-630.43E74-like factor 5 [Source:MGI Symbol;Acc:MGI:13350... [more]
Elf51.808e-630.43E74-like factor 5 [Source:MGI Symbol;Acc:MGI:13350... [more]
Elf51.808e-630.43E74-like factor 5 [Source:MGI Symbol;Acc:MGI:13350... [more]
Elf51.808e-630.43E74-like factor 5 [Source:MGI Symbol;Acc:MGI:13350... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 2
Match NameE-valueIdentityDescription
sp|A8WFJ9|ETS4_CAEEL6.064e-734.94Transcription factor ets-4 OS=Caenorhabditis elega... [more]
sp|P29775|ETS4_DROME7.423e-634.12DNA-binding protein D-ETS-4 OS=Drosophila melanoga... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1I8GPB91.588e-939.76ETS domain-containing protein OS=Macrostomum ligna... [more]
A0A267GQD51.916e-939.76ETS domain-containing protein OS=Macrostomum ligna... [more]
A0A1I8FYC81.975e-938.82ETS domain-containing protein OS=Macrostomum ligna... [more]
A0A267F0N92.080e-939.76ETS domain-containing protein OS=Macrostomum ligna... [more]
A0A267FM466.105e-937.93Uncharacterized protein OS=Macrostomum lignano OX=... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
spi1b8.523e-725.42Spi-1 proto-oncogene [Source:NCBI gene;Acc:1030330... [more]
spi1b1.037e-625.42Spi-1 proto-oncogene [Source:NCBI gene;Acc:1030330... [more]
spi1b1.134e-625.42Spi-1 proto-oncogene [Source:NCBI gene;Acc:1030330... [more]
SPDEF2.855e-634.94SAM pointed domain containing ETS transcription fa... [more]
SPDEF2.855e-634.94SAM pointed domain containing ETS transcription fa... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4
Match NameE-valueIdentityDescription
EDO453611.746e-635.23Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO443391.808e-631.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO289132.581e-633.33Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO492617.993e-642.11Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
elf31.476e-629.29ETS-related transcription factor Elf-3 [Source:NCB... [more]
SPDEF3.236e-634.94SAM pointed domain containing ETS transcription fa... [more]
ENSORLT00000007127.27.554e-631.43transcription factor PU.1 [Source:NCBI gene;Acc:10... [more]
ENSORLT00000040237.18.135e-631.43transcription factor PU.1 [Source:NCBI gene;Acc:10... [more]
back to top
BLAST of ETS homologous factor isoform X2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000069597.10.000e+099.64SMESG000069597.1[more]
SMESG000069596.12.484e-9951.83SMESG000069596.1[more]
SMESG000069596.13.689e-9858.90SMESG000069596.1[more]
SMESG000035130.12.903e-4536.69SMESG000035130.1[more]
SMESG000035130.14.596e-4536.69SMESG000035130.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30020022 ID=SMED30020022|Name=ETS homologous factor isoform X2|organism=Schmidtea mediterranea sexual|type=transcript|length=1049bp
ATTTAGTAACATTTACATCCTTCTGATTTTTGATTGGCTGTCATTTTTAT
TCTTGGAAATTCGCAAAATTGTCAATTTTTTATAATTAACCATGGAATTG
GGCTATTCAGAAAATGATATGATTTTCAATGACATATTTTTTGGAGATAT
TGATTGCACAGAAAATGTGATTGGATCTAACAATGAAATTTCCGATGAAG
ATTCATTACCCCAGGATTTTAATCTAGAAGAGACTTTGATTGATGAAACA
GATATTTGCGTGGATTATATTTGTCCGGAAGATTCAATAATCATTCAAAA
TAATTTCGTAAACTTTATGAAAAGTCAAGAATTGCATTTGTACAAAGAAA
CTTTCATTGAAAAATATTTTACATCTTACAAATGCCCCACAGATCACATC
GTTCAAAGAACTCGAACACAACTGTGGATGGAGAACTGTATATACGGATT
ACAGCTTCAAGCCTACATTTGCATGGTAAAAGATATCCCGTTGCCAATTG
TGCCTCAAAGAAACCGAAAACAACCTATTTTAAAGAAAAAAAATTTGACA
CAAGCCAGAAAAGGAGTTTTTCAAGATGTTGTTTTAGAATATCTATTCCA
AAAATGCCGAAACGTATCAGAATTTGTCAGTTTTAGACATCGCGATGCTC
CTAGAAATCAGATTGGATTATTAATATTTATCCTGGATTTGCTAAATCAT
CCTTACTATAAAGGTTGTATAAGGTGGGTAGATAAAGGTTCTTTGATCTT
CAAAATTATCAATTCAAAACTCGTGGCGTACTATTGGATGGTCGTCAAAG
AAAACGACACATGCAATATCGAGAATTTTGCTAGAGGGATTCGATATTTG
CGGCGGGTGGGATTTTTCAAACAAATTAACAAGAAAGCGCAACGAACTTA
TCAATTCAACAAAAAAGCCATTAAAGAATACGAAAAAAAACGTTTGACCA
ATAATTTGACAAATGCTTTATTGAACAACTTAAACTGAACTTTTGAAACA
AGATGTTTTTACTTTTTAGAATCATTTTATTATTCAAGAATGTGTAGAT
back to top

protein sequence of SMED30020022-orf-1

>SMED30020022-orf-1 ID=SMED30020022-orf-1|Name=SMED30020022-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=299bp
MELGYSENDMIFNDIFFGDIDCTENVIGSNNEISDEDSLPQDFNLEETLI
DETDICVDYICPEDSIIIQNNFVNFMKSQELHLYKETFIEKYFTSYKCPT
DHIVQRTRTQLWMENCIYGLQLQAYICMVKDIPLPIVPQRNRKQPILKKK
NLTQARKGVFQDVVLEYLFQKCRNVSEFVSFRHRDAPRNQIGLLIFILDL
LNHPYYKGCIRWVDKGSLIFKIINSKLVAYYWMVVKENDTCNIENFARGI
RYLRRVGFFKQINKKAQRTYQFNKKAIKEYEKKRLTNNLTNALLNNLN*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000034epidermis
PLANA:0000101muscle cell
PLANA:0000142posterior region of the whole animal
Vocabulary: INTERPRO
TermDefinition
IPR036388WH-like_DNA-bd_sf
IPR036390WH_DNA-bd_sf
IPR000418Ets_dom
IPR011991WHTH_DNA-bd_dom
Vocabulary: molecular function
TermDefinition
GO:0043565sequence-specific DNA binding
GO:0003700transcription factor activity, sequence-specific DNA binding
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677DNA binding
Vocabulary: biological process
TermDefinition
GO:0006355regulation of transcription, DNA-templated
GO:0006357regulation of transcription from RNA polymerase II promoter
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 263..283
NoneNo IPR availablePANTHERPTHR11849ETScoord: 158..277
IPR000418Ets domainSMARTSM00413etsneu2coord: 190..277
e-value: 1.0E-10
score: 51.6
IPR000418Ets domainPFAMPF00178Etscoord: 193..272
e-value: 8.4E-16
score: 58.2
IPR000418Ets domainPROSITEPS50061ETS_DOMAIN_3coord: 191..273
score: 10.771
IPR036388Winged helix-like DNA-binding domain superfamilyGENE3DG3DSA:1.10.10.10coord: 160..291
e-value: 4.1E-18
score: 67.3
IPR036390Winged helix DNA-binding domain superfamilySUPERFAMILYSSF46785"Winged helix" DNA-binding domaincoord: 160..276