Disks large homolog 1

Overview


Name	Disks large homolog 1
Smed ID	SMED30019914
Length (bp)	3470

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Disks large homolog 1 (SMED30019914) t-SNE clustered cells

Violin plots show distribution of expression levels for Disks large homolog 1 (SMED30019914) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Disks large homolog 1 (SMED30019914) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Disks large homolog 1 (SMED30019914) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019914

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30019914	h1SMcG0020202	SmedASXL_001287	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
nervous system	SMED30019914	h1SMcG0020202	dd_Smed_v4_7374_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30019914	h1SMcG0020202	dd_Smed_v4_7374_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30019914	h1SMcG0020202	dd_Smed_v4_7374_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30019914	h1SMcG0020202	dd_Smed_v4_7374_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
head region	SMED30019914	h1SMcG0020202	dd_Smed_v6_7374_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
photoreceptor neuron	SMED30019914	h1SMcG0020202	SMED30019914	smed_20140614	PMID:22884275 Lapan et al., 2012
neuron	SMED30019914	h1SMcG0020202	Contig21285	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
neuron	SMED30019914	h1SMcG0020202	Contig21285	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30019914	h1SMcG0020202	Contig21285	newmark_ests	PMID:27612384 Roberts-Galbraith et al., 2016
lateral branch	SMED30019914	h1SMcG0020202	Contig21285	uc_Smed_v2	PMID:27612384 Roberts-Galbraith et al., 2016

Note: Hover over icons to view figure legend

Homology

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BLAST of Disks large homolog 1 vs. Ensembl Human
Match: DLG2 (discs large MAGUK scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:2901])

HSP 1 Score: 278.87 bits (712), Expect = 2.850e-84
Identity = 144/359 (40.11%), Postives = 223/359 (62.12%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V    ++  +G+IPS  R+ RKE+   K V F+++    +SK + +P  G   +      G+ +   Q   ED                 ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:    6 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGD-IPGLGDDGY------GTKTLRGQ---ED-----------------LILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 332

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Human
Match: DLG2 (discs large MAGUK scaffold protein 2 [Source:HGNC Symbol;Acc:HGNC:2901])

HSP 1 Score: 278.87 bits (712), Expect = 4.954e-84
Identity = 143/359 (39.83%), Postives = 228/359 (63.51%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V    ++  +G+IPS  R+ RKE+   K V F+++    +SK + +P  G          G  +K+ ++++ + S +       +     ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:    6 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGD-IPGLGDD--------GYGTKTLKHVSSNASDS----ESSYRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 346

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Human
Match: DLG3 (discs large MAGUK scaffold protein 3 [Source:HGNC Symbol;Acc:HGNC:2902])

HSP 1 Score: 277.715 bits (709), Expect = 1.982e-83
Identity = 144/350 (41.14%), Postives = 220/350 (62.86%), Query Frame = 3

Query: 2325 VTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
             + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F ++     S + S+    K SF    +     KS +N+ ++ S  ++ +    +++          +L YEP+ +  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME+ I+  +FIEAGQ+ DNLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++AL  ++ + T  QA++   KA +L+ +   YFTA+V  DS   +Y++IK I++  SG  IWVP+
Sbjct:   15 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNR-SIKTKRKKSFRLSRKF-PFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 362

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Human
Match: DLG3 (discs large MAGUK scaffold protein 3 [Source:HGNC Symbol;Acc:HGNC:2902])

HSP 1 Score: 278.87 bits (712), Expect = 5.520e-82
Identity = 144/350 (41.14%), Postives = 220/350 (62.86%), Query Frame = 3

Query: 2325 VTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
             + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F ++     S + S+    K SF    +     KS +N+ ++ S  ++ +    +++          +L YEP+ +  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME+ I+  +FIEAGQ+ DNLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++AL  ++ + T  QA++   KA +L+ +   YFTA+V  DS   +Y++IK I++  SG  IWVP+
Sbjct:  161 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNR-SIKTKRKKSFRLSRKF-PFYKSKENMAQESSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 508

HSP 2 Score: 92.4337 bits (228), Expect = 1.115e-18
Identity = 45/99 (45.45%), Postives = 66/99 (66.67%), Query Frame = 3

Query: 1581 KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            + PR ++L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+++ ++      EY  FESK +
Sbjct:   45 REPRKIILHKG--STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIH 141

HSP 3 Score: 80.1073 bits (196), Expect = 8.795e-15
Identity = 41/87 (47.13%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + +V Q  P
Sbjct:   51 ILHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP 130

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Human
Match: DLG1 (discs large MAGUK scaffold protein 1 [Source:HGNC Symbol;Acc:HGNC:2900])

HSP 1 Score: 280.026 bits (715), Expect = 6.493e-82
Identity = 141/344 (40.99%), Postives = 221/344 (64.24%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            ++K   YVRALF++D   +  LPS+ L F   DI+ ++N++D +WWQAR V  + E+  +G+IPS  R+ +KE+   K V F+S    K   K  +P +          +GS  K  +++T + S ++      +      +L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY ++LYGTS+ +VR+VA K KHC+LDV+  AIKRL  A L PI+I IKP S++ +  ++ ++T  QA +  ++A +L+ + + +FTA+V  D+   +Y+Q+K I++  SGS IWVP  +
Sbjct:  226 SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNS----KTRDKGEIPDD----------MGS--KGLKHVTSNASDSES----SYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKE 549

HSP 2 Score: 63.1586 bits (152), Expect = 2.456e-9
Identity = 36/96 (37.50%), Postives = 52/96 (54.17%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFY-IDILSNNYLSISDKTQETLNFLNSLKL 344
            MPV   D  +A+ LLE YRSKLS+T D+ L  +I++VIN+F S  F AL+D            IQ FY + +L N       K  E +  +N+ ++
Sbjct:    1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALID------------IQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEI 84

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Match: dlg-1 (Disks large homolog 1 [Source:UniProtKB/Swiss-Prot;Acc:G5ECY0])

HSP 1 Score: 243.047 bits (619), Expect = 3.084e-66
Identity = 137/361 (37.95%), Postives = 216/361 (59.83%), Query Frame = 3

Query: 2346 YVRALFEFDPDVEKNL-PSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDS--QLVSKNSKKNSLP-RNGKPS---------FIKRM-QLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVA-ANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQS------KISHYFTAVVWED-----SFNGLYSQIKSIVQCNSGSDIWVP 3347
            YVRALF++DP  E ++ P R + F   DI+ I+NS+D +WW AR V +N E    G+IPS  R+ ++E+  +K+VNF+S  Q + +NS    L  R G  S         F+K   +L  +++ + N+ E+  ++                 Y+ + + +++YVRPV+I+G L+D+IND L++  P+ F+SCVPHT+R  +  EV+G+DYYFV ++  MEE +K+  FIEAGQ+++NLYGTSI +VRDVA + +HC+LDV+  AI+RL + AN+ PI+I IKP S + +  L S++   + D      EE Q+      +I   F  +  ++     S N + S++ SI+   S + IWVP
Sbjct:  623 YVRALFDYDPSRENSVAPHRSMGFNYGDILHIINSSDDEWWTARKVHENGEETAEGVIPSKKRVEKRERLRRKQVNFNSGSQSLGRNSSTTGLENRRGSRSQLSFSRKFPFVKSTDRLNDLNEESSNVAEEPVWS-----------------YQAVEQQAINYVRPVIILGALKDRINDELVNRDPSKFSSCVPHTSRPPREGEVNGRDYYFV-NKHNMEEDVKNNLFIEAGQFQNNLYGTSIQSVRDVANQGRHCILDVSGNAIRRLQSNANIQPISIFIKPSSAQQILELDSQLATNRQDDRAMSGEEAQAQYSRCHRIEQTFGDLFTQEISNVHSANDVLSKVYSIISRESQTPIWVP 965

HSP 2 Score: 139.813 bits (351), Expect = 3.133e-33
Identity = 97/250 (38.80%), Postives = 147/250 (58.80%), Query Frame = 3

Query: 1149 ISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNN-VTEQF--EEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLS-RPNETV----GFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            I L+KG RGLGFSI GG+GNEH  GD  IY+TK++++GAA   G +  GDK+++V+ + L + THE AV +L N G++V L I +    + N+  ++QF    P     S +D + S   + S +   G           +++++ +++P  + L  RP + V    G GFNIVGGED + I++SF++P G+AD +GN+  GD + +VNG  +  ATH EAA  L+ +G  + L L     EY  FESK 
Sbjct:  362 IDLVKGARGLGFSIAGGQGNEHVKGDTDIYVTKIIEEGAAELDGRLRVGDKILEVDHHSLINTTHENAVNVLKNTGNRVRLLIQQGTGAIFNDSASQQFMPTTPILRPSSVQDYNRSQMGSQSHLSYGGP----------LNTSYSSQAPIAIPLEPRPVQLVKGQNGLGFNIVGGEDNEPIYISFVLPGGVADLSGNVKTGDVLLEVNGVVLRNATHKEAAEALRNAGNPVYLTLQYRPQEYQIFESKI 601

HSP 3 Score: 70.0922 bits (170), Expect = 9.218e-12
Identity = 38/92 (41.30%), Postives = 55/92 (59.78%), Query Frame = 3

Query:  606 RPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            RP      ++KG+ G GFS+AGG  N +    D  IYVTKI   G+ +L G L + D+IL V+  ++   THE AV+ LK  G+ + L+IQ+
Sbjct:  356 RPNTSVIDLVKGARGLGFSIAGGQGNEHVK-GDTDIYVTKIIEEGAAELDGRLRVGDKILEVDHHSLINTTHENAVNVLKNTGNRVRLLIQQ 446

HSP 4 Score: 69.3218 bits (168), Expect = 1.284e-11
Identity = 36/94 (38.30%), Postives = 56/94 (59.57%), Query Frame = 3

Query:  606 RPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            RP+ +    +KG  G GF++ GG DN      +P IY++ + PGG  DLSG++   D +L VNG+ +   TH+ A  AL+ AG+ ++L +Q  P
Sbjct:  509 RPVQL----VKGQNGLGFNIVGGEDN------EP-IYISFVLPGGVADLSGNVKTGDVLLEVNGVVLRNATHKEAAEALRNAGNPVYLTLQYRP 591

HSP 5 Score: 68.1662 bits (165), Expect = 3.187e-11
Identity = 58/219 (26.48%), Postives = 101/219 (46.12%), Query Frame = 3

Query: 1221 GDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK-------PNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVD-SNFINKSPRIVVLSRPNETVGFGFNIVGGE-------DEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            GD  IY+T +++ GAA   G + + D +  VN+    +V HE AV  L + G+ V L + +       P  G     T       +   S+ +L  ++ +  +P+        H     ++    + +  P   V+       G GF+I GG+       D D I+V+ II  G A+ +G + VGD+I +V+   +   TH+ A ++LK +G  + LL+
Sbjct:  227 GDTSIYVTNIIEGGAALADGRMRKNDIITAVNNTNCENVKHEVAVNALKSSGNVVSLSLKRRKDEAFLPIGGNFGGSTSYLRSGVTPSVSAGNLQHAIHSPSAPIHPPPPPPVHHGSLSQLSVGQYRSTRPNTSVIDLVKGARGLGFSIAGGQGNEHVKGDTD-IYVTKIIEEGAAELDGRLRVGDKILEVDHHSLINTTHENAVNVLKNTGNRVRLLI 444

HSP 6 Score: 67.0106 bits (162), Expect = 7.909e-11
Identity = 37/89 (41.57%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  618 MEAVIL-KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            +E ++L KG TG GFS+ GG+D P     D  IYVT I  GG+    G +  +D I +VN  N   + HE AV+ALK +G+ + L ++R
Sbjct:  200 LENIVLEKGHTGLGFSITGGMDQPT-EDGDTSIYVTNIIEGGAALADGRMRKNDIITAVNNTNCENVKHEVAVNALKSSGNVVSLSLKR 287

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Match: lin-2 (pep chromosome:WBcel235:X:12399517:12406131:-1 gene:WBGene00002991.1 transcript:F17E5.1b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-2)

HSP 1 Score: 112.849 bits (281), Expect = 2.796e-25
Identity = 88/355 (24.79%), Postives = 166/355 (46.76%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPS--RPLAFLTNDIILIVNSADPDWWQARVV------------EDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
             +VRA F+++P  +  +P     + F T DI+ +++  D +WWQAR V            + +N+    G+IPSP     +E R        + L  + SK      N   +            + + + +  +  D+          L L+ YE ++++S    + +V++G     R  I +TLI  HPN FA  +PHTTR  +  EV GK YYFV +  +M   I++ E++E G +++++YGT +  +R++ K  K  +LDV   A+K L  A   P  + I  P+++ + +    +     ++ + +++ L+    H F  ++     +   +Q++ +V+       W+P  
Sbjct:  295 IFVRAQFDYEPSQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGLIPSPEL---QEWRT-------ACLAMERSK------NTCNTHCMWFNKKKKYYTTKYLQKHSALFDQ----------LDLVTYEEVMRLSQYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTNE-QMMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRTAEYSPFVVFIAAPNLQGMQDPDGSL-----EKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQLERLVEKLPAYPQWLPVT 617

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Match: lin-2 (pep chromosome:WBcel235:X:12399517:12414037:-1 gene:WBGene00002991.1 transcript:F17E5.1a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:lin-2)

HSP 1 Score: 113.62 bits (283), Expect = 3.191e-25
Identity = 88/354 (24.86%), Postives = 166/354 (46.89%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPS--RPLAFLTNDIILIVNSADPDWWQARVV------------EDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
             +VRA F+++P  +  +P     + F T DI+ +++  D +WWQAR V            + +N+    G+IPSP     +E R        + L  + SK      N   +            + + + +  +  D+          L L+ YE ++++S    + +V++G     R  I +TLI  HPN FA  +PHTTR  +  EV GK YYFV +  +M   I++ E++E G +++++YGT +  +R++ K  K  +LDV   A+K L  A   P  + I  P+++ + +    +     ++ + +++ L+    H F  ++     +   +Q++ +V+       W+P 
Sbjct:  636 IFVRAQFDYEPSQDDLIPCPQAGIPFKTGDILQVISKDDHNWWQARFVSSFPSIGNSSNAQRSNQQQVAGLIPSPEL---QEWRT-------ACLAMERSK------NTCNTHCMWFNKKKKYYTTKYLQKHSALFDQ----------LDLVTYEEVMRLSQYRRKTLVLLGAHGVGRRHIKNTLIHRHPNRFAYPIPHTTRPPRKDEVDGKHYYFVTN-EQMMADIQNNEYLEYGTHEESMYGTKLETIRNIHKSGKIAILDVEPQALKVLRTAEYSPFVVFIAAPNLQGMQDPDGSL-----EKLLNESDVLRQAFGHLFDFIITNSDIDDTIAQLERLVEKLPAYPQWLPV 957

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Match: magu-1 (MAGUK family [Source:UniProtKB/TrEMBL;Acc:Q95XW5])

HSP 1 Score: 96.2857 bits (238), Expect = 3.688e-20
Identity = 74/272 (27.21%), Postives = 123/272 (45.22%), Query Frame = 3

Query: 2346 YVRALFEFDP--DVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRN-KKKVNF-DSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPP 3149
            Y RALF++DP  D     P   ++F   DI+ I++  D  WWQ R +         G +      +  E R+  KKV    S+ +   S+   +P NG  +          S   Q+  E+  +   +    F   N        ++         +   G  R++I         + F + +PHT+R ++P E  G +YYF   RSEME  I+ +E +E G+++DNLYGT++ +VR  ++    +L  + LAI+ +      PI I ++PP
Sbjct:  224 YARALFDYDPWQDKRHPCPEAAISFRGGDILEILDEKDQYWWQTRKI-------GFGALARRKESHDDENRDDSKKVGLVPSEWLQCQSE---IPENGIDT----------SDDFQSFLEN--HKGRFYESVFRWRNKKKRRRVVVL---------LGAPGVGRNEIRRQFFKVFADRFTNAIPHTSRPQRPNESDGVNYYFTS-RSEMERMIERKEMLEYGEFRDNLYGTALKSVRKASEKGTVLLTPHPLAIENIRTWEFAPIVIFVQPP 463

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Match: magu-2 (MAGUK family [Source:UniProtKB/TrEMBL;Acc:A0A3B1DQX2])

HSP 1 Score: 95.5153 bits (236), Expect = 8.586e-20
Identity = 85/348 (24.43%), Postives = 165/348 (47.41%), Query Frame = 3

Query: 2346 YVRALFEFDPDVEKNLPSRPLA--FLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKI-SLDYVRPVVIIGPLRD---KINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDV-AKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSS-KITVAQADREVK----KAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
            ++RALF++DP+ +  +P + LA  F   DI+ ++N+ D +WWQA    ++ ++   G+IPS +         +++V   +  V +  ++      GK      ++ G+     +N+     Y+D             L Y E ++++    + RP+V+ G       K+ D L++      A  VP+T+R+ K  E +G  Y+FV  + +  E  K  +F+E G+Y+   YGT+   V +V  + K CV+ + A ++  + + ++ P  I I  PS+  L      + T    D E+K    +++ ++ K  H F  ++    F   + ++K I+   +   +WVP  
Sbjct:  341 HLRALFDYDPEDDVYVPCKELAMKFQRGDILHVLNTKDDNWWQAYRDGEDIQHSLAGLIPSSS--------FRQQVVLYADEVEREQEQKRKECKGKKKKKLEVKKGA---DEENLPAIGVYSD------------FLTYEEVVLELPKATHRRPIVLCGAEGVGCLKLRDRLLESDRITLACPVPYTSRTPKEGEFNGVHYHFV-SKQKFHEDAKSGKFVEFGEYQKFWYGTAKKDVVNVIERGKTCVMTLKAESLGAIRSPDIQPYIIFIAAPSLYILRRQREVEGTFGVKDDELKAILTQSKSIEQKYGHLFDGIIVNIDFEKSFRELKQILMKVNTEPMWVPAT 664

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0073490)

HSP 1 Score: 303.523 bits (776), Expect = 2.606e-87
Identity = 157/370 (42.43%), Postives = 232/370 (62.70%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S  + +M          E  +E N+  L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  549 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENV--LSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 910

HSP 2 Score: 151.369 bits (381), Expect = 7.681e-37
Identity = 139/448 (31.03%), Postives = 204/448 (45.54%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEE------------------------------PFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P                                         +++ I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K     ++                                      P  N QS++  S   S N       G+          V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++  
Sbjct:  162 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGP-----------------------------------------KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPR-------AVSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQ 539

HSP 3 Score: 73.1738 bits (178), Expect = 1.052e-12
Identity = 41/93 (44.09%), Postives = 60/93 (64.52%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVI 875
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I
Sbjct:  267 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLII 358

HSP 4 Score: 71.2478 bits (173), Expect = 4.070e-12
Identity = 42/109 (38.53%), Postives = 56/109 (51.38%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTAS 953
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A 
Sbjct:  449 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAG 550

HSP 5 Score: 64.3142 bits (155), Expect = 6.801e-10
Identity = 38/89 (42.70%), Postives = 50/89 (56.18%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNF 326
            MPV   +A +A+ELLE Y ++LSE  D+ L  AI++VI +F S+ F ALLD            IQ FY   L ++  SI  KT ETL  
Sbjct:    1 MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLD------------IQEFYELTLLDDSKSIQQKTAETLQI 77

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0112812)

HSP 1 Score: 303.138 bits (775), Expect = 3.820e-87
Identity = 157/370 (42.43%), Postives = 232/370 (62.70%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S  + +M          E  +E N+  L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  549 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENV--LSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 910

HSP 2 Score: 150.599 bits (379), Expect = 1.350e-36
Identity = 141/447 (31.54%), Postives = 205/447 (45.86%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILKPN------------------------------SGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P                                         +++ I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K                                   S    +Q   P  N QS++  S   S N       G+          V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++ 
Sbjct:  162 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGP-----------------------------------------KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPR-------AVSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARI 538

HSP 3 Score: 72.7886 bits (177), Expect = 1.405e-12
Identity = 41/95 (43.16%), Postives = 61/95 (64.21%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVIQR 881
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I +
Sbjct:  267 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK 360

HSP 4 Score: 70.8626 bits (172), Expect = 5.968e-12
Identity = 42/109 (38.53%), Postives = 56/109 (51.38%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTAS 953
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A 
Sbjct:  449 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAG 550

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0073488)

HSP 1 Score: 303.523 bits (776), Expect = 6.389e-87
Identity = 157/370 (42.43%), Postives = 232/370 (62.70%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S  + +M          E  +E N+  L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  608 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENV--LSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 969

HSP 2 Score: 151.754 bits (382), Expect = 6.584e-37
Identity = 139/447 (31.10%), Postives = 204/447 (45.64%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEE------------------------------PFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P                                         +++ I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K     ++                                      P  N QS++  S   S N       G+          V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++ 
Sbjct:  221 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGP-----------------------------------------KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPR-------AVSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARI 597

HSP 3 Score: 73.9442 bits (180), Expect = 7.589e-13
Identity = 41/93 (44.09%), Postives = 60/93 (64.52%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVI 875
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I
Sbjct:  326 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLII 417

HSP 4 Score: 72.0182 bits (175), Expect = 2.932e-12
Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTA 950
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A
Sbjct:  508 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGA 608

HSP 5 Score: 63.929 bits (154), Expect = 7.913e-10
Identity = 38/89 (42.70%), Postives = 50/89 (56.18%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNF 326
            MPV   +A +A+ELLE Y ++LSE  D+ L  AI++VI +F S+ F ALLD            IQ FY   L ++  SI  KT ETL  
Sbjct:    1 MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLD------------IQEFYELTLLDDSKSIQQKTAETLQI 77

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0333262)

HSP 1 Score: 301.597 bits (771), Expect = 2.333e-86
Identity = 155/361 (42.94%), Postives = 231/361 (63.99%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S      +++ +E N+  L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  596 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGS------DQEPSEENV--LSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 942

HSP 2 Score: 94.7449 bits (234), Expect = 2.566e-19
Identity = 89/260 (34.23%), Postives = 130/260 (50.00%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P+ I+                                         I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K
Sbjct:   53 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGPKVIE-----------------------------------------IDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK 251

HSP 3 Score: 82.0333 bits (201), Expect = 2.525e-15
Identity = 43/105 (40.95%), Postives = 61/105 (58.10%), Query Frame = 3

Query: 1560 VDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++ 
Sbjct:  483 VSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARI 585

HSP 4 Score: 72.7886 bits (177), Expect = 1.680e-12
Identity = 41/95 (43.16%), Postives = 61/95 (64.21%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVIQR 881
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I +
Sbjct:  158 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK 251

HSP 5 Score: 70.8626 bits (172), Expect = 6.382e-12
Identity = 42/109 (38.53%), Postives = 56/109 (51.38%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTAS 953
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A 
Sbjct:  496 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAG 597

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Match: dlg1 (gene:FBgn0001624 transcript:FBtr0073485)

HSP 1 Score: 293.893 bits (751), Expect = 1.525e-83
Identity = 155/380 (40.79%), Postives = 231/380 (60.79%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLM-------------------LLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S  D+  N   +  + +                   +L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  588 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGS--DQEPNGVVSSTSEIDINNVNNNQSNEPQPSEENVLSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 959

HSP 2 Score: 95.5153 bits (236), Expect = 1.913e-19
Identity = 88/260 (33.85%), Postives = 130/260 (50.00%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P+                                         ++ I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K
Sbjct:   45 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGPK-----------------------------------------VIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK 243

HSP 3 Score: 82.0333 bits (201), Expect = 2.551e-15
Identity = 43/105 (40.95%), Postives = 61/105 (58.10%), Query Frame = 3

Query: 1560 VDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++ 
Sbjct:  475 VSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARI 577

HSP 4 Score: 72.7886 bits (177), Expect = 1.651e-12
Identity = 41/95 (43.16%), Postives = 61/95 (64.21%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVIQR 881
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I +
Sbjct:  150 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGK 243

HSP 5 Score: 70.8626 bits (172), Expect = 5.567e-12
Identity = 42/109 (38.53%), Postives = 56/109 (51.38%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTAS 953
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A 
Sbjct:  488 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGAG 589

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 275.789 bits (704), Expect = 7.402e-83
Identity = 141/357 (39.50%), Postives = 225/357 (63.03%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++    ++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP SV+AL  L+ + T  QA++   KA +L+ +   +FTA+V  DS + +Y++IK I++  SG  IW+P+ +
Sbjct:   16 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEALMELNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPSAE 364

[Close]

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++    ++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP SV+AL  L+ + T  QA++   KA +L+ +   +FTA+V  DS + +Y++IK I++  SG  IW+P+ +
Sbjct:   16 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEALMELNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPSAE 364

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 277.33 bits (708), Expect = 2.382e-78
Identity = 141/350 (40.29%), Postives = 220/350 (62.86%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++    +             +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP SV+AL  L+ + T  QA++   KA +L+ +   +FTA+V  DS + +Y++IK I++  SG  IW+P+ +
Sbjct:  517 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETERKYERGTRGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEALMELNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPSAE 858

HSP 2 Score: 138.658 bits (348), Expect = 7.368e-33
Identity = 97/260 (37.31%), Postives = 147/260 (56.54%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIF---------FDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            I+ ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+ +L DV HEEAV  L N    V LK+ KP      ++ + +  P  +      +   + +N S   + G +    ++         +  V  + +      + PR ++L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  243 ILEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAKPG---PVHLNDMYAPPDYSSTFPTMVDNHVGHNSSMAYMGGMEPK-PVYQPPQVTPSRYSPVPRHMLGEEDFTREPRKILLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRPEEYSRFESKIH 496

HSP 3 Score: 91.6633 bits (226), Expect = 2.865e-18
Identity = 39/87 (44.83%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E ++ +G++G GFS+AGG+DNP+   +DPGI++TKI PGG+  + G L ++D +L VN ++++ + H  AV ALKEAG  + L+++R
Sbjct:  150 EIILERGNSGLGFSIAGGMDNPHIP-DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLVRR 235

HSP 4 Score: 76.6406 bits (187), Expect = 1.166e-13
Identity = 40/87 (45.98%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + ++ Q  P
Sbjct:  406 LLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRP 485

HSP 5 Score: 71.633 bits (174), Expect = 4.244e-12
Identity = 37/89 (41.57%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L   D++L+VN I +  + HE AV+ALK   D ++L + +
Sbjct:  243 ILEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAK 330

HSP 6 Score: 58.151 bits (139), Expect = 7.152e-8
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            ++L R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D+S   H +A   LK +G  + LL+
Sbjct:  151 IILERGNS--GLGFSIAGGMDNPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLV 233

HSP 7 Score: 51.9878 bits (123), Expect = 5.450e-6
Identity = 26/66 (39.39%), Postives = 40/66 (60.61%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            N H   DPGI+ITK++  GAAA  G +   D +++VND  +++V H +AV+ L   G  V L + +
Sbjct:  170 NPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLVRR 235

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 275.404 bits (703), Expect = 1.068e-77
Identity = 145/367 (39.51%), Postives = 224/367 (61.04%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVP--------HTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V    ++  +G+IPS  R+ RKE+   K V F       N+K  SL   G  S  +R       K      +D    D   +E+  E   ++L YEP+++  ++Y RPV+I+GP++D+IND LI E P+ F SCVP         TTR K+ +EV G+DY+F+  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I IKP S+++L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  508 MSSGSGSLRTNQ-----KRSLYVRALFDYERAKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTPEGDSEEMGVIPSKRRVERKERARLKTVKF-------NAKPGSLDSKGSFSEKRRKNFIFSRKFPFYKNKDADEQDGSDSERSQEE--LILSYEPVIRQEINYARPVIILGPMKDRINDDLISEFPDKFGSCVPPANSSDQEDTTRPKRDYEVDGRDYHFMASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSIESLMEMNKRLTEEQAKKTYDRAMKLEQEFGEYFTALVQGDTLEDIYNQCKMVIEEQSGPYIWIPSKE 860

HSP 2 Score: 155.606 bits (392), Expect = 4.145e-38
Identity = 112/271 (41.33%), Postives = 152/271 (56.09%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGV------SNNVTEQFEEPFSNCQSSKDLSESLSNNDS-----PVR--------LNGSDNNHDIFFDEVDSN------FINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +  I LIKG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP S          ++T  F     N  SS   + +L    S     P R        L   D N +   DE++ +      F  + PR +VL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+T+ ++      EY  FE+K +
Sbjct:  229 VTEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGKPTSVYLSDPYGPPDITHSFSPAMENHISSPGNNGTLEYKSSLPPISPGRYSPLPKHLLGEEDINRNPSLDEMEGHRFDSQHFQLREPRKIVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRPEEYGRFEAKIH 497

HSP 3 Score: 83.1889 bits (204), Expect = 1.295e-15
Identity = 39/87 (44.83%), Postives = 59/87 (67.82%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN  +++ ++H  AV ALK AG  + L ++R
Sbjct:  136 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRR 221

HSP 4 Score: 78.5666 bits (192), Expect = 3.823e-14
Identity = 42/87 (48.28%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + ++ Q  P
Sbjct:  407 VLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRP 486

HSP 5 Score: 69.707 bits (169), Expect = 1.918e-11
Identity = 40/98 (40.82%), Postives = 57/98 (58.16%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            RP+   V E  ++KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN   +  +THE AV+ LK   D ++L + + PT
Sbjct:  223 RPMLETVTEIKLIKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGK-PT 318

HSP 6 Score: 66.6254 bits (161), Expect = 1.596e-10
Identity = 59/218 (27.06%), Postives = 96/218 (44.04%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H +AV+ L   GS V L + +    +   VTE         +  K L  S++         G  N H                                 I G   ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK +   + L +    + Y++
Sbjct:  156 NPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYVRR-RRPMLETVTE-----IKLIKGPKGLGFSIA--------GGVGNQH---------------------------------IPG---DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTSDVVYLKVGKPTSVYLS 323

HSP 7 Score: 57.7658 bits (138), Expect = 7.995e-8
Identity = 32/85 (37.65%), Postives = 48/85 (56.47%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN +D+S  +H +A   LK +G  + L +
Sbjct:  137 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNESDVSEVSHSKAVEALKAAGSIVRLYV 219

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 274.633 bits (701), Expect = 1.766e-77
Identity = 141/357 (39.50%), Postives = 225/357 (63.03%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++    ++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP SV+AL  L+ + T  QA++   KA +L+ +   +FTA+V  DS + +Y++IK I++  SG  IW+P+ +
Sbjct:  505 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVETEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSVEALMELNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLDEIYNKIKLIIEEQSGPYIWIPSAE 853

HSP 2 Score: 135.576 bits (340), Expect = 7.346e-32
Identity = 96/262 (36.64%), Postives = 146/262 (55.73%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNV--TEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIF---------FDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            I+ ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+ +L DV HEEAV  L N    V LK+ KP     N++     +        +   + ++   ++S +   G      ++         +  V  + +      + PR ++L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  225 ILEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAKPGPVHLNDMYAPPDYSSSLGLPPAFPTMVDNHVGHNSSMAYMGGMEPKPVYQPPQVTPSRYSPVPRHMLGEEDFTREPRKILLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRPEEYSRFESKIH 484

HSP 3 Score: 92.0485 bits (227), Expect = 2.708e-18
Identity = 39/87 (44.83%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E ++ +G++G GFS+AGG+DNP+   +DPGI++TKI PGG+  + G L ++D +L VN ++++ + H  AV ALKEAG  + L+++R
Sbjct:  132 EIILERGNSGLGFSIAGGMDNPHIP-DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLVRR 217

HSP 4 Score: 77.0258 bits (188), Expect = 1.123e-13
Identity = 40/87 (45.98%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + ++ Q  P
Sbjct:  394 LLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRP 473

HSP 5 Score: 71.633 bits (174), Expect = 4.160e-12
Identity = 37/89 (41.57%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L   D++L+VN I +  + HE AV+ALK   D ++L + +
Sbjct:  225 ILEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAK 312

HSP 6 Score: 58.9214 bits (141), Expect = 3.646e-8
Identity = 40/121 (33.06%), Postives = 61/121 (50.41%), Query Frame = 3

Query: 1488 SLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + SN D   ++NGSD  +   ++E+            +L R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D+S   H +A   LK +G  + LL+
Sbjct:  111 TCSNRDWYDQVNGSDGMYK--YEEI------------ILERGNS--GLGFSIAGGMDNPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLV 215

HSP 7 Score: 51.6026 bits (122), Expect = 5.873e-6
Identity = 26/66 (39.39%), Postives = 40/66 (60.61%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            N H   DPGI+ITK++  GAAA  G +   D +++VND  +++V H +AV+ L   G  V L + +
Sbjct:  152 NPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNDVDVSEVVHSKAVEALKEAGPVVRLLVRR 217

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Match: hmmr (hyaluronan-mediated motility receptor (RHAMM) [Source:Xenbase;Acc:XB-GENE-5851601])

HSP 1 Score: 279.256 bits (713), Expect = 1.194e-79
Identity = 144/348 (41.38%), Postives = 214/348 (61.49%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNF------DSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F      DS    K+ +K S   + K  F K            ++ +D S A    +         +L YEP+ +  + Y RPV+I+GPL+D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++AL  ++ + T  QA +   KA +L+ +   +FTA+V  DS   +Y++IK I++ +SG  IWVP+
Sbjct:  420 SEKRSLYVRALFDYDRSRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHGRSGIDSNRSIKSKRKKSFRLSRKFPFYK------------SLVQDNSTAQGQED--------TILSYEPVTRQEIHYARPVIILGPLKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVGSREQMEKDIQENKFIEAGQFNDNLYGTSVQSVRAVAERGKHCILDVSGNAIKRLQQAQLFPIAIFIKPKSIEALMEMNRRQTFEQAQKMFDKATKLEQEFGEFFTAIVQGDSLEEIYNKIKQIIEDHSGHHIWVPS 747

HSP 2 Score: 137.502 bits (345), Expect = 1.826e-32
Identity = 103/261 (39.46%), Postives = 147/261 (56.32%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNV--TEQFEEPFS---NCQSSKDLSESLSNNDS-----PVRLNGSDNNHDIFFDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            IV ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+  L DV HEEAV  L N    V LK+ KP     N +     +   F+   +   +  L   LS+ +S     P ++  S       F  V  + +      + PR ++L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  147 IVEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAALKNTSDMVYLKVAKPGPVHLNEIYAPPDYASTFTVDNHISHNSTLGAYLSSMESKSPYPPPQVTPSR------FSPVPRHMLGEEDFTREPRKIILHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRSATHEQAAAALKRAGQTVTIVAQYRPEEYSRFESKIH 399

HSP 3 Score: 94.3597 bits (233), Expect = 5.864e-19
Identity = 42/87 (48.28%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E V+ +G++G GFS+AGGIDNP+   +DPGI++TKI PGG+  + G L++ D +L VN +++T + H  AV ALKEAG  + L+++R
Sbjct:   54 EIVLERGNSGLGFSIAGGIDNPHVP-DDPGIFITKIIPGGAAAMDGRLSVSDCVLRVNDVDVTEVVHSKAVEALKEAGPVVRLLVRR 139

HSP 4 Score: 78.5666 bits (192), Expect = 4.827e-14
Identity = 41/87 (47.13%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + +V Q  P
Sbjct:  309 ILHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRSATHEQAAAALKRAGQTVTIVAQYRP 388

HSP 5 Score: 74.7146 bits (182), Expect = 7.129e-13
Identity = 38/89 (42.70%), Postives = 55/89 (61.80%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L I D++L+VN  N+  + HE AV+ALK   D ++L + +
Sbjct:  147 IVEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAALKNTSDMVYLKVAK 234

HSP 6 Score: 65.4698 bits (158), Expect = 4.889e-10
Identity = 64/235 (27.23%), Postives = 96/235 (40.85%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLT----TDMNEYVA---FESKFNWNTH 1889
            N H   DPGI+ITK++  GAAA  G +S  D +++VND  +T+V H +AV+ L   G  V L + +  S     V           +  K L  S++         G   N  I  D  +S +I K                                 II  G A K+G + +GDR+  VN T++    H+EA + LK +   + L +       +NE  A   + S F  + H
Sbjct:   74 NPHVPDDPGIFITKIIPGGAAAMDGRLSVSDCVLRVNDVDVTEVVHSKAVEALKEAGPVVRLLVRRRQSPPETIVEVNL------LKGPKGLGFSIA---------GGIGNQHIPGD--NSIYITK---------------------------------IIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEAVAALKNTSDMVYLKVAKPGPVHLNEIYAPPDYASTFTVDNH 258

HSP 7 Score: 57.7658 bits (138), Expect = 1.096e-7
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            +VL R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D++   H +A   LK +G  + LL+
Sbjct:   55 IVLERGNS--GLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLSVSDCVLRVNDVDVTEVVHSKAVEALKEAGPVVRLLV 137

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 280.411 bits (716), Expect = 1.365e-79
Identity = 143/359 (39.83%), Postives = 225/359 (62.67%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +S+  S     K SFI   +        Q  TE ++   E   E        +L YEP+ +  ++Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR K+ +E+ G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I +KP SV++L  +S ++T  QA +   +A +L+ +   +FTA+V  D+   +Y+  K +++  SG  IWVP+ +
Sbjct:  468 MSSGSGSLRTNQ-----KRSLYVRAMFDYEKSKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTQDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSR-GSFNDKRKKSFIFSRKFPFFKNKDQ--TEQETSDPERGQED------CILSYEPVTRQEINYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEMDGRDYHFVASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFLKPKSVESLMEISKRLTEEQAKKTFDRALKLEQEFGEFFTAIVQGDTLEDIYNSCKQVIEEQSGPFIWVPSKE 812

HSP 2 Score: 87.0409 bits (214), Expect = 1.003e-16
Identity = 40/81 (49.38%), Postives = 59/81 (72.84%), Query Frame = 3

Query:  639 GSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            G++G GFS+AGGIDNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   55 GNSGLGFSIAGGIDNPHVG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 134

HSP 3 Score: 78.5666 bits (192), Expect = 5.074e-14
Identity = 45/101 (44.55%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
             ++ PR V+L +   + G GFNIVGGED +GIF+SFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G T+ ++      EY  FE+K +
Sbjct:  359 FHREPRKVILHK--GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQPEEYARFEAKIH 457

HSP 4 Score: 72.4034 bits (176), Expect = 3.864e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  136 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 233

HSP 5 Score: 72.0182 bits (175), Expect = 4.281e-12
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  142 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 232

HSP 6 Score: 65.4698 bits (158), Expect = 4.411e-10
Identity = 58/208 (27.88%), Postives = 91/208 (43.75%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNV-TEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLEL 1826
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H  AV+ L   GS V L + +    +   V  + F+ P       K L  S++         G  N H                                 I G   ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK +   + L
Sbjct:   69 NPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGP-------KGLGFSIA--------GGVGNQH---------------------------------IPG---DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYL 225

HSP 7 Score: 61.6178 bits (148), Expect = 7.973e-9
Identity = 39/89 (43.82%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+++ I  GG  DLSG L   DQI+SVNGI++   +HE A +ALK AG  + +V Q  P
Sbjct:  365 KVILHKGSTGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQP 446

HSP 8 Score: 54.6842 bits (130), Expect = 9.110e-7
Identity = 29/75 (38.67%), Postives = 42/75 (56.00%), Query Frame = 3

Query: 1626 GFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            G GF+I GG       D+ GIF++ IIP G A ++G + V D I +VN  D+S  +H  A   LK +G  + L +
Sbjct:   58 GLGFSIAGGIDNPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYV 132

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 280.026 bits (715), Expect = 3.659e-79
Identity = 143/359 (39.83%), Postives = 225/359 (62.67%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +S+  S     K SFI   +        Q  TE ++   E   E        +L YEP+ +  ++Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR K+ +E+ G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I +KP SV++L  +S ++T  QA +   +A +L+ +   +FTA+V  D+   +Y+  K +++  SG  IWVP+ +
Sbjct:  507 MSSGSGSLRTNQ-----KRSLYVRAMFDYEKSKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTQDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSR-GSFNDKRKKSFIFSRKFPFFKNKDQ--TEQETSDPERGQED------CILSYEPVTRQEINYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEMDGRDYHFVASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFLKPKSVESLMEISKRLTEEQAKKTFDRALKLEQEFGEFFTAIVQGDTLEDIYNSCKQVIEEQSGPFIWVPSKE 851

HSP 2 Score: 87.0409 bits (214), Expect = 1.183e-16
Identity = 40/81 (49.38%), Postives = 59/81 (72.84%), Query Frame = 3

Query:  639 GSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            G++G GFS+AGGIDNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   94 GNSGLGFSIAGGIDNPHVG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 173

HSP 3 Score: 78.5666 bits (192), Expect = 4.299e-14
Identity = 45/101 (44.55%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
             ++ PR V+L +   + G GFNIVGGED +GIF+SFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G T+ ++      EY  FE+K +
Sbjct:  398 FHREPRKVILHK--GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQPEEYARFEAKIH 496

HSP 4 Score: 72.0182 bits (175), Expect = 4.826e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  175 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 272

HSP 5 Score: 71.633 bits (174), Expect = 5.870e-12
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  181 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 271

HSP 6 Score: 61.2326 bits (147), Expect = 9.161e-9
Identity = 39/89 (43.82%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+++ I  GG  DLSG L   DQI+SVNGI++   +HE A +ALK AG  + +V Q  P
Sbjct:  404 KVILHKGSTGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQP 485

HSP 7 Score: 55.0694 bits (131), Expect = 7.682e-7
Identity = 29/75 (38.67%), Postives = 42/75 (56.00%), Query Frame = 3

Query: 1626 GFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            G GF+I GG       D+ GIF++ IIP G A ++G + V D I +VN  D+S  +H  A   LK +G  + L +
Sbjct:   97 GLGFSIAGGIDNPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYV 171

HSP 8 Score: 51.6026 bits (122), Expect = 9.027e-6
Identity = 26/66 (39.39%), Postives = 41/66 (62.12%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H  AV+ L   GS V L + +
Sbjct:  108 NPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 173

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 280.796 bits (717), Expect = 5.444e-79
Identity = 143/359 (39.83%), Postives = 225/359 (62.67%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +S+  S     K SFI   +        Q  TE ++   E   E        +L YEP+ +  ++Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR K+ +E+ G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I +KP SV++L  +S ++T  QA +   +A +L+ +   +FTA+V  D+   +Y+  K +++  SG  IWVP+ +
Sbjct:  567 MSSGSGSLRTNQ-----KRSLYVRAMFDYEKSKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTQDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSR-GSFNDKRKKSFIFSRKFPFFKNKDQ--TEQETSDPERGQED------CILSYEPVTRQEINYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEMDGRDYHFVASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFLKPKSVESLMEISKRLTEEQAKKTFDRALKLEQEFGEFFTAIVQGDTLEDIYNSCKQVIEEQSGPFIWVPSKE 911

HSP 2 Score: 117.087 bits (292), Expect = 6.128e-26
Identity = 107/309 (34.63%), Postives = 153/309 (49.51%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------------------------GVSNNVTEQFEEPFSNCQSSKD--------LSESLSNNDSPV-----RLNGSDNNHDIFFD-EVDSNFINKSP-----------------RIVVLSR-PNETV------GFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +                           +NN T +++ P +     +         + +  + +  PV     +L    +    F   E D +F+  SP                  IV   R P + +      G GFNIVGGED +GIF+SFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G T+ ++      EY  FE+K +
Sbjct:  248 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPLESHILSSANNGTLEYKSPLAPISPGRYSPIPKHMLVEDDYTRSPEPVYSTVNKLAEKPSTPRHFSPVECDKSFLLTSPYPTFHGGLMSELEISRCHIVCFHREPRKVILHKGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQPEEYARFEAKIH 556

HSP 3 Score: 86.6557 bits (213), Expect = 1.704e-16
Identity = 40/81 (49.38%), Postives = 59/81 (72.84%), Query Frame = 3

Query:  639 GSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            G++G GFS+AGGIDNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:  161 GNSGLGFSIAGGIDNPHVG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 240

HSP 4 Score: 71.633 bits (174), Expect = 6.076e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  242 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 339

HSP 5 Score: 61.2326 bits (147), Expect = 1.105e-8
Identity = 39/89 (43.82%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+++ I  GG  DLSG L   DQI+SVNGI++   +HE A +ALK AG  + +V Q  P
Sbjct:  464 KVILHKGSTGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQP 545

HSP 6 Score: 54.6842 bits (130), Expect = 1.075e-6
Identity = 29/75 (38.67%), Postives = 42/75 (56.00%), Query Frame = 3

Query: 1626 GFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            G GF+I GG       D+ GIF++ IIP G A ++G + V D I +VN  D+S  +H  A   LK +G  + L +
Sbjct:  164 GLGFSIAGGIDNPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYV 238

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Match: hjv (hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB-GENE-922976])

HSP 1 Score: 279.641 bits (714), Expect = 5.787e-79
Identity = 143/359 (39.83%), Postives = 225/359 (62.67%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +S+  S     K SFI   +        Q  TE ++   E   E        +L YEP+ +  ++Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR K+ +E+ G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I +KP SV++L  +S ++T  QA +   +A +L+ +   +FTA+V  D+   +Y+  K +++  SG  IWVP+ +
Sbjct:  524 MSSGSGSLRTNQ-----KRSLYVRAMFDYEKSKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTQDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSR-GSFNDKRKKSFIFSRKFPFFKNKDQ--TEQETSDPERGQED------CILSYEPVTRQEINYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEMDGRDYHFVASREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFLKPKSVESLMEISKRLTEEQAKKTFDRALKLEQEFGEFFTAIVQGDTLEDIYNSCKQVIEEQSGPFIWVPSKE 868

HSP 2 Score: 117.472 bits (293), Expect = 5.317e-26
Identity = 107/309 (34.63%), Postives = 153/309 (49.51%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------------------------GVSNNVTEQFEEPFSNCQSSKD--------LSESLSNNDSPV-----RLNGSDNNHDIFFD-EVDSNFINKSP-----------------RIVVLSR-PNETV------GFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +                           +NN T +++ P +     +         + +  + +  PV     +L    +    F   E D +F+  SP                  IV   R P + +      G GFNIVGGED +GIF+SFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G T+ ++      EY  FE+K +
Sbjct:  205 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPLESHILSSANNGTLEYKSPLAPISPGRYSPIPKHMLVEDDYTRSPEPVYSTVNKLAEKPSTPRHFSPVECDKSFLLTSPYPTFHGGLMSELEISRCHIVCFHREPRKVILHKGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQPEEYARFEAKIH 513

HSP 3 Score: 87.0409 bits (214), Expect = 1.103e-16
Identity = 40/81 (49.38%), Postives = 59/81 (72.84%), Query Frame = 3

Query:  639 GSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            G++G GFS+AGGIDNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:  118 GNSGLGFSIAGGIDNPHVG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 197

HSP 4 Score: 72.0182 bits (175), Expect = 4.673e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  199 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 296

HSP 5 Score: 61.6178 bits (148), Expect = 8.627e-9
Identity = 39/89 (43.82%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+++ I  GG  DLSG L   DQI+SVNGI++   +HE A +ALK AG  + +V Q  P
Sbjct:  421 KVILHKGSTGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELQRGDQIISVNGIDLRGASHEQAAAALKGAGLTVTIVAQYQP 502

HSP 6 Score: 55.0694 bits (131), Expect = 6.924e-7
Identity = 29/75 (38.67%), Postives = 42/75 (56.00%), Query Frame = 3

Query: 1626 GFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            G GF+I GG       D+ GIF++ IIP G A ++G + V D I +VN  D+S  +H  A   LK +G  + L +
Sbjct:  121 GLGFSIAGGIDNPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYV 195

HSP 7 Score: 51.6026 bits (122), Expect = 9.315e-6
Identity = 26/66 (39.39%), Postives = 41/66 (62.12%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H  AV+ L   GS V L + +
Sbjct:  132 NPHVGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKEAGSIVRLYVRR 197

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 282.722 bits (722), Expect = 6.506e-84
Identity = 145/366 (39.62%), Postives = 233/366 (63.66%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK  S     K SFI   +     K+ +   ++ S  +++++   +++         ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  121 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSK-GSFNDKRKKSFIFSRKF-PFYKNKEQSEQETSDPEQHVSSNASDSESSCRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 479

HSP 2 Score: 94.3597 bits (233), Expect = 1.657e-19
Identity = 46/97 (47.42%), Postives = 66/97 (68.04%), Query Frame = 3

Query: 1587 PRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:   16 PRKVVLHKG--STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 110

HSP 3 Score: 78.5666 bits (192), Expect = 1.790e-14
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:   18 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 99

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Match: Dlg3 (discs large MAGUK scaffold protein 3 [Source:MGI Symbol;Acc:MGI:1888986])

HSP 1 Score: 278.87 bits (712), Expect = 3.395e-82
Identity = 144/350 (41.14%), Postives = 220/350 (62.86%), Query Frame = 3

Query: 2325 VTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
             + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F ++     S + S+    K SF    +     KS +N+ ++ S  ++ +    +++          +L YEP+ +  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME+ I+  +FIEAGQ+ DNLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++AL  ++ + T  QA++   KA +L+ +   YFTA+V  DS   +Y++IK I++  SG  IWVP+
Sbjct:  161 TSEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHARTGMIESNR-SIKTKRKKSFRLSRKF-PFYKSKENMAQENSIQEQGVTSNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNRRQTYEQANKIFDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVPS 508

HSP 2 Score: 92.4337 bits (228), Expect = 7.788e-19
Identity = 45/99 (45.45%), Postives = 66/99 (66.67%), Query Frame = 3

Query: 1581 KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            + PR ++L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+++ ++      EY  FESK +
Sbjct:   45 REPRKIILHKG--STGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIH 141

HSP 3 Score: 80.4925 bits (197), Expect = 5.730e-15
Identity = 41/87 (47.13%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + +V Q  P
Sbjct:   51 ILHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRP 130

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 284.263 bits (726), Expect = 1.180e-80
Identity = 146/361 (40.44%), Postives = 226/361 (62.60%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFI--KRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK  S     K SFI  ++       + ++  T D     E +          +L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  524 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSK-GSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL----------ILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 868

HSP 2 Score: 94.7449 bits (234), Expect = 3.503e-19
Identity = 46/101 (45.54%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  415 LEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513

HSP 3 Score: 87.0409 bits (214), Expect = 8.004e-17
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   98 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183

HSP 4 Score: 77.411 bits (189), Expect = 9.087e-14
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  421 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502

HSP 5 Score: 72.0182 bits (175), Expect = 3.757e-12
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 281

HSP 6 Score: 72.0182 bits (175), Expect = 3.789e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  185 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 282

HSP 7 Score: 56.225 bits (134), Expect = 2.360e-7
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:   99 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181

HSP 8 Score: 53.9138 bits (128), Expect = 1.405e-6
Identity = 61/213 (28.64%), Postives = 86/213 (40.38%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLEL 1826
            N H   DPGI+ITK++  GAAA        D  ++VND               C         IL+ N           E   S    SK + E+L    S VRL           + V    + K P+           G GF+I GG        ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK +   + L
Sbjct:  118 NPHIGDDPGIFITKIIPGGAAAE-------DGRLRVND---------------C---------ILRVN-----------EVDVSEVSHSKAV-EALKEAGSIVRL--YVRRRRPILETVVEIKLFKGPK-----------GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYL 274

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 281.182 bits (718), Expect = 1.647e-80
Identity = 142/359 (39.55%), Postives = 220/359 (61.28%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK + +P  G                           D Y  +       ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  427 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGD-IPGLGD--------------------------DGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 753

HSP 2 Score: 141.739 bits (356), Expect = 6.473e-34
Identity = 104/273 (38.10%), Postives = 146/273 (53.48%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNN------VTEQFEEPFSN---------CQSSKDLSESLSNNDSPV--RLNGSDN-----NHDIFFDEVDSNF-----INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +    +      +T  +  P  N          +    L        SP+   + G D+      H     +          +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  146 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTIYMTDPYGPPDITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLGEDDYTSHSQHSTATRQPSVTLQRAISLEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 416

HSP 3 Score: 86.6557 bits (213), Expect = 1.053e-16
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   53 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 138

HSP 4 Score: 76.6406 bits (187), Expect = 1.184e-13
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  324 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 405

HSP 5 Score: 71.633 bits (174), Expect = 4.784e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  140 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 237

HSP 6 Score: 55.4546 bits (132), Expect = 4.689e-7
Identity = 43/144 (29.86%), Postives = 70/144 (48.61%), Query Frame = 3

Query: 1419 SNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            S +  E ++  +    S K   E++ +   PV  NG++  ++  F+E+             L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:   11 SASRAENYQLLWDTIASLKQCEEAMQHAFIPV--NGTEIEYE--FEEI------------TLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 136

HSP 7 Score: 51.6026 bits (122), Expect = 7.269e-6
Identity = 26/66 (39.39%), Postives = 42/66 (63.64%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK 1403
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H +AV+ L   GS V L + +
Sbjct:   73 NPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 138

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Match: Dlg2 (discs large MAGUK scaffold protein 2 [Source:MGI Symbol;Acc:MGI:1344351])

HSP 1 Score: 281.952 bits (720), Expect = 1.826e-79
Identity = 145/366 (39.62%), Postives = 233/366 (63.66%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK  S     K SFI   +     K+ +   ++ S  +++++   +++         ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  559 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSK-GSFNDKRKKSFIFSRKF-PFYKNKEQSEQETSDPEQHVSSNASDSESSCRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 917

HSP 2 Score: 94.7449 bits (234), Expect = 3.794e-19
Identity = 46/101 (45.54%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  450 LEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 548

HSP 3 Score: 87.0409 bits (214), Expect = 8.249e-17
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:  133 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 218

HSP 4 Score: 77.411 bits (189), Expect = 9.697e-14
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  456 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 537

HSP 5 Score: 72.0182 bits (175), Expect = 3.796e-12
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  226 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 316

HSP 6 Score: 72.0182 bits (175), Expect = 4.312e-12
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  220 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 317

HSP 7 Score: 56.225 bits (134), Expect = 2.946e-7
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:  134 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 216

HSP 8 Score: 53.1434 bits (126), Expect = 2.419e-6
Identity = 61/213 (28.64%), Postives = 86/213 (40.38%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLEL 1826
            N H   DPGI+ITK++  GAAA        D  ++VND               C         IL+ N           E   S    SK + E+L    S VRL           + V    + K P+           G GF+I GG        ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK +   + L
Sbjct:  153 NPHIGDDPGIFITKIIPGGAAAE-------DGRLRVND---------------C---------ILRVN-----------EVDVSEVSHSKAV-EALKEAGSIVRL--YVRRRRPILETVVEIKLFKGPK-----------GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYL 309

[Close]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Match: sp|P31007|DLG1_DROME (Disks large 1 tumor suppressor protein OS=Drosophila melanogaster OX=7227 GN=dlg1 PE=1 SV=2)

HSP 1 Score: 303.523 bits (776), Expect = 6.404e-86
Identity = 157/370 (42.43%), Postives = 232/370 (62.70%), Query Frame = 3

Query: 2286 SNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNS--KKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN 3359
            + GSG L       T+K   YVRALF++DP+ +  LPSR L F   DI+ + N++D +WWQAR V  +NE+  +GI+PS  R  RK +   + V F     + N+  K+++L R  K +F    +   M KS     ED S  + +M          E  +E N+  L YE + ++S++Y RPV+I+GPL+D+IND LI E+P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L P+ + IKP SV ++  ++ ++T  QA +  ++A +++ +   YFT VV  D+   +YS++KS++   SG  IWVP+ ++
Sbjct:  608 AGGSGTLLR----TTQKRSLYVRALFDYDPNRDDGLPSRGLPFKHGDILHVTNASDDEWWQARRVLGDNEDEQIGIVPSKRRWERKMRARDRSVKFQGHAAANNNLDKQSTLDRK-KKNFTFSRKFPFM-KSRDEKNEDGSDQEPFMLCYTQDDANAEGASEENV--LSYEAVQRLSINYTRPVIILGPLKDRINDDLISEYPDKFGSCVPHTTRPKREYEVDGRDYHFVSSREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPVAVFIKPKSVDSVMEMNRRMTEEQAKKTYERAIKMEQEFGEYFTGVVQGDTIEEIYSKVKSMIWSQSGPTIWVPSKES 969

HSP 2 Score: 151.754 bits (382), Expect = 6.600e-36
Identity = 139/447 (31.10%), Postives = 204/447 (45.64%), Query Frame = 3

Query:  636 KGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQV----NDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEE------------------------------PFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKF 1874
            +G++G GFS+AGG DNP+    D  IY+TK+  GG+    G L+I+D I+SVN +++  + H +AV ALK+AG+ + L                +++RK  + T      +  D+   + S+   P                                         +++ I L+KG +GLGFSI GG GN+H  GD GIY+TK+MD GAA   G +S GDKL+ V    ++  L +VTHE AV  L ++  KV L I K     ++                                      P  N QS++  S   S N       G+          V +  I + PR + + +  +  G GFNIVGGED  GI+VSFI+  G AD    +  GD++  VN  +++ ATH+EAA  LK SG  + LL      EY  FE++ 
Sbjct:  221 RGNSGLGFSIAGGTDNPHIG-TDTSIYITKLISGGAAAADGRLSINDIIVSVNDVSVVDVPHASAVDALKKAGNVVKL----------------HVKRKRGTATTPAAGSAAGDA---RDSAASGP-----------------------------------------KVIEIDLVKGGKGLGFSIAGGIGNQHIPGDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLIIGKTQHLTTSASGGGGGGLSSGQQLSQSQSQLATSQSQSQVHQQQHATPMVNSQSTEPGSRYASTNVLAAVPPGTPR-------AVSTEDITREPRTITIQKGPQ--GLGFNIVGGEDGQGIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARI 597

HSP 3 Score: 73.9442 bits (180), Expect = 7.607e-12
Identity = 41/93 (44.09%), Postives = 60/93 (64.52%), Query Frame = 3

Query:  609 PIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSV--NGI--NMTYLTHEAAVSALKEAGDELHLVI 875
            P V+E  ++KG  G GFS+AGGI N +    D GIYVTK+  GG+  + G L+I D++++V  NG   N+  +THE AV+ LK   D++ L+I
Sbjct:  326 PKVIEIDLVKGGKGLGFSIAGGIGNQHIP-GDNGIYVTKLMDGGAAQVDGRLSIGDKLIAVRTNGSEKNLENVTHELAVATLKSITDKVTLII 417

HSP 4 Score: 72.0182 bits (175), Expect = 2.939e-11
Identity = 42/108 (38.89%), Postives = 56/108 (51.85%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTA 950
             I KG  G GF++ GG D         GIYV+ I  GG  DL   L   DQ+LSVN +N+T+ THE A  ALK +G  + L+ Q  P   +R        ++ A+L A
Sbjct:  508 TIQKGPQGLGFNIVGGEDGQ-------GIYVSFILAGGPADLGSELKRGDQLLSVNNVNLTHATHEEAAQALKTSGGVVTLLAQYRPEEYNRFEARIQELKQQAALGA 608

HSP 5 Score: 63.929 bits (154), Expect = 7.932e-9
Identity = 38/89 (42.70%), Postives = 50/89 (56.18%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNF 326
            MPV   +A +A+ELLE Y ++LSE  D+ L  AI++VI +F S+ F ALLD            IQ FY   L ++  SI  KT ETL  
Sbjct:    1 MPVKKQEAHRALELLEDYHARLSEPQDRALRIAIERVIRIFKSRLFQALLD------------IQEFYELTLLDDSKSIQQKTAETLQI 77

[Close]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Match: sp|Q15700|DLG2_HUMAN (Disks large homolog 2 OS=Homo sapiens OX=9606 GN=DLG2 PE=1 SV=3)

HSP 1 Score: 282.722 bits (722), Expect = 2.722e-79
Identity = 146/361 (40.44%), Postives = 225/361 (62.33%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFI--KRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V    ++  +G+IPS  R+ RKE+   K V F+++    +SK  S     K SFI  ++       + ++  T D     E +          +L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  524 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSK-GSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL----------ILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 868

HSP 2 Score: 94.7449 bits (234), Expect = 2.472e-18
Identity = 46/101 (45.54%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  415 LEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513

HSP 3 Score: 87.4261 bits (215), Expect = 5.185e-16
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   98 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183

HSP 4 Score: 77.411 bits (189), Expect = 6.143e-13
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  421 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502

HSP 5 Score: 72.0182 bits (175), Expect = 2.313e-11
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTT 281

HSP 6 Score: 70.4774 bits (171), Expect = 8.363e-11
Identity = 39/99 (39.39%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   + ++L + +  T+
Sbjct:  185 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKVGKPTTI 282

HSP 7 Score: 56.6102 bits (135), Expect = 1.582e-6
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:   99 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181

HSP 8 Score: 54.6842 bits (130), Expect = 5.241e-6
Identity = 61/213 (28.64%), Postives = 87/213 (40.85%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLEL 1826
            N H   DPGI+ITK++  GAAA        D  ++VND               C         IL+ N           E   S    SK + E+L    S VRL           + V    + K P+           G GF+I GG        ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK + + + L
Sbjct:  118 NPHIGDDPGIFITKIIPGGAAAE-------DGRLRVND---------------C---------ILRVN-----------EVDVSEVSHSKAV-EALKEAGSIVRL--YVRRRRPILETVVEIKLFKGPK-----------GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYL 274

[Close]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Match: sp|Q91XM9|DLG2_MOUSE (Disks large homolog 2 OS=Mus musculus OX=10090 GN=Dlg2 PE=1 SV=2)

HSP 1 Score: 279.641 bits (714), Expect = 2.204e-78
Identity = 142/359 (39.55%), Postives = 220/359 (61.28%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK + +P  G                           D Y  +       ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  524 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVTLDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGD-IPGLGD--------------------------DGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 850

HSP 2 Score: 94.7449 bits (234), Expect = 2.903e-18
Identity = 46/101 (45.54%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  415 LEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513

HSP 3 Score: 86.6557 bits (213), Expect = 7.956e-16
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   98 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183

HSP 4 Score: 76.6406 bits (187), Expect = 9.290e-13
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  421 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502

HSP 5 Score: 71.633 bits (174), Expect = 3.472e-11
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 281

HSP 6 Score: 71.2478 bits (173), Expect = 4.081e-11
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  185 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 282

HSP 7 Score: 55.8398 bits (133), Expect = 2.187e-6
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:   99 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181

[Close]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Match: sp|Q12959|DLG1_HUMAN (Disks large homolog 1 OS=Homo sapiens OX=9606 GN=DLG1 PE=1 SV=2)

HSP 1 Score: 280.796 bits (717), Expect = 2.369e-78
Identity = 141/344 (40.99%), Postives = 221/344 (64.24%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            ++K   YVRALF++D   +  LPS+ L F   DI+ ++N++D +WWQAR V  + E+  +G+IPS  R+ +KE+   K V F+S    K   K  +P +          +GS  K  +++T + S ++      +      +L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY ++LYGTS+ +VR+VA K KHC+LDV+  AIKRL  A L PI+I IKP S++ +  ++ ++T  QA +  ++A +L+ + + +FTA+V  D+   +Y+Q+K I++  SGS IWVP  +
Sbjct:  579 SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNS----KTRDKGEIPDD----------MGS--KGLKHVTSNASDSES----SYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKE 902

HSP 2 Score: 132.88 bits (333), Expect = 4.405e-30
Identity = 102/252 (40.48%), Postives = 142/252 (56.35%), Query Frame = 3

Query: 1137 RIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNF-----INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +I+ I LIKG +GLGFSI GG GN+H  GD  IY+TK+++ GAA   G +  GDKL+ VN+  L +VTHEEAV  L N    V LK+ KP S   N+        ++    +   S+ + N+ SP    G        +  V         I + PR VVL R   + G GFNIVGGED +GIF+SFI+  G AD +G +  GDRI  VN  D+  A+H++AA+ LK +G+ + ++      EY  FE+K +
Sbjct:  316 KIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMND-------GYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHR--GSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIH 558

HSP 3 Score: 78.5666 bits (192), Expect = 2.504e-13
Identity = 38/87 (43.68%), Postives = 57/87 (65.52%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +D  I++TKI  GG+    G L ++D IL VN +++  +TH  AV ALKEAG  + L ++R
Sbjct:  224 EITLERGNSGLGFSIAGGTDNPHIG-DDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKR 309

HSP 4 Score: 77.0258 bits (188), Expect = 7.573e-13
Identity = 40/92 (43.48%), Postives = 58/92 (63.04%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            +ME  ++KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L I D++L+VN + +  +THE AV+ALK   D ++L + + PT
Sbjct:  317 IMEIKLIKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAK-PT 406

HSP 5 Score: 60.8474 bits (146), Expect = 6.915e-8
Identity = 36/96 (37.50%), Postives = 52/96 (54.17%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFY-IDILSNNYLSISDKTQETLNFLNSLKL 344
            MPV   D  +A+ LLE YRSKLS+T D+ L  +I++VIN+F S  F AL+D            IQ FY + +L N       K  E +  +N+ ++
Sbjct:    1 MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALID------------IQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEI 84

HSP 6 Score: 59.3066 bits (142), Expect = 1.885e-7
Identity = 36/89 (40.45%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ +GSTG GF++ GG D         GI+++ I  GG  DLSG L   D+I+SVN +++   +HE A +ALK AG  + +V Q  P
Sbjct:  466 KVVLHRGSTGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRP 547

[Close]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Match: sp|Q63622|DLG2_RAT (Disks large homolog 2 OS=Rattus norvegicus OX=10116 GN=Dlg2 PE=1 SV=1)

HSP 1 Score: 278.87 bits (712), Expect = 5.272e-78
Identity = 142/359 (39.55%), Postives = 220/359 (61.28%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRA+F++D   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F+++    +SK + +P  G                           D Y  +       ++L YEP+ +  ++Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++ L  ++ ++T  QA +   +A +L+ +   YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  524 MSSGSGSLRTNQ-----KRSLYVRAMFDYDKSKDSGLPSQGLSFKYGDILHVINASDDEWWQARRVILDGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGD-IPGLGD--------------------------DGYGTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRLTEEQAKKTYDRAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIPSKE 850

HSP 2 Score: 94.3597 bits (233), Expect = 3.056e-18
Identity = 46/101 (45.54%), Postives = 67/101 (66.34%), Query Frame = 3

Query: 1575 INKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +   PR VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  A+H++AA+ LKG+G+T+ ++      +Y  FE+K +
Sbjct:  415 LEGEPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAKIH 513

HSP 3 Score: 86.6557 bits (213), Expect = 8.518e-16
Identity = 40/87 (45.98%), Postives = 61/87 (70.11%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALKEAG  + L ++R
Sbjct:   98 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYVRR 183

HSP 4 Score: 76.6406 bits (187), Expect = 9.945e-13
Identity = 41/89 (46.07%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   +HE A +ALK AG  + ++ Q  P
Sbjct:  421 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQP 502

HSP 5 Score: 71.633 bits (174), Expect = 3.561e-11
Identity = 49/91 (53.85%), Postives = 62/91 (68.13%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS 1412
            +V I L KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP +
Sbjct:  191 VVEIKLFKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTT 281

HSP 6 Score: 71.2478 bits (173), Expect = 4.259e-11
Identity = 40/99 (40.40%), Postives = 58/99 (58.59%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTL 893
            RPI   V+E  + KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN  ++  +THE AV+ LK   D ++L + +  T+
Sbjct:  185 RPILETVVEIKLFKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSDVVYLKVGKPTTI 282

HSP 7 Score: 55.8398 bits (133), Expect = 2.341e-6
Identity = 32/85 (37.65%), Postives = 47/85 (55.29%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H +A   LK +G  + L +
Sbjct:   99 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSKAVEALKEAGSIVRLYV 181

[Close]

BLAST of Disks large homolog 1 vs. TrEMBL
Match: C3YXG4 (Uncharacterized protein OS=Branchiostoma floridae OX=7739 GN=BRAFLDRAFT_278615 PE=4 SV=1)

HSP 1 Score: 299.286 bits (765), Expect = 4.133e-88
Identity = 149/355 (41.97%), Postives = 223/355 (62.82%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSK-------KNSLPRNGKPSFIKR----MQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            ++K   YVRALF++D   +  LPS+ L+F   DI+ +VN++D +WWQAR+V    E   LG+IPS  R+ RKE+   K+V F    +   S+       K +L  + K  F K     M    M + + N ++ +S   E   E     +  +L YE +V+  L Y RPV+I+GPL+D++ND LI E P+ F SCVPHTTRSK+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+V++VA K KHC+LDV+  AIKRL  A L P+ I IKP S++++  ++ +IT  QA +  ++A++L+ + + YFTA+V  D+ + +Y ++K ++Q NS    WVP  +
Sbjct:   14 SQKRSLYVRALFDYDKTKDSGLPSQGLSFKFGDILHVVNASDDEWWQARLVTATGEEEGLGVIPSKRRVERKERARLKQVKFTRGTLEPGSRSSLSDKRKKNLVLSRKFPFYKNKDSDMDTSDMEQVSTNASDSESSYREITGESEGGVDEPVLSYEAVVQQELKYTRPVIILGPLKDRVNDDLISEFPDKFGSCVPHTTRSKREYEVDGRDYHFVGSREQMERDIQNHLFIEAGQYNDNLYGTSVASVKEVADKGKHCILDVSGNAIKRLQVAQLFPVAIFIKPKSIESIMEMNKRITEEQARKTYERAQKLEQEFAEYFTAIVQGDTIDEIYDKVKGVIQDNSQQTAWVPAKE 368

[Close]

BLAST of Disks large homolog 1 vs. TrEMBL
Match: A0A1B6MPK7 (Uncharacterized protein OS=Graphocephala atropunctata OX=36148 GN=g.36955 PE=4 SV=1)

HSP 1 Score: 298.13 bits (762), Expect = 1.231e-87
Identity = 156/367 (42.51%), Postives = 229/367 (62.40%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
            IS  +G L       ++K   YVRALF++DP  +  LPSR LAF   DI+ + N++D +WWQAR V  + E   LGI+PS  R  RK++   + V F   +     K+++L R  K  SF ++       KS  + +ED S  + +M         +E   EA   +L YEP+ ++ +DY RPV+I+GPL+D++ND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L PI + IKP SV+++  ++ ++T  QA +  ++A +++++   YFTAVV  D+   +Y ++K ++   SG  IWVP+
Sbjct:    5 ISTSTGTLLR----TSQKRSLYVRALFDYDPLKDDGLPSRGLAFHYGDILHVTNASDDEWWQARRVLWSGEQEGLGIVPSKKRWERKQRARDRTVKFQGHMPVMLDKQSTLDRKKKNFSFSRKF---PFMKSKDDKSEDGSDQEPFMLCYTQDDPSSEGTEEA---VLSYEPVSQLQIDYTRPVIILGPLKDRVNDDLISEFPDQFGSCVPHTTRPKREYEVDGRDYHFVASREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPIAVFIKPKSVESIMEMNKRMTEEQAKKTFERAMKMEAEFGEYFTAVVQGDTPEDIYQKVKEVINDQSGPTIWVPS 361

[Close]

BLAST of Disks large homolog 1 vs. TrEMBL
Match: A0A482VHQ1 (Disks large 1 tumor suppressor protein (Fragment) OS=Asbolus verrucosus OX=1661398 GN=BDFB_003447 PE=4 SV=1)

HSP 1 Score: 301.212 bits (770), Expect = 1.681e-87
Identity = 153/354 (43.22%), Postives = 224/354 (63.28%), Query Frame = 3

Query: 2325 VTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKS--------YADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
             ++K   YVRALF++DP  +  LPSR LAF   DI+ + N++D +WWQAR V +  +   +GI+PS  R  RK++   + V F   + +   K+++L R  K  SF ++       KS  + +ED S        Y  E  N +  E N+  L YEP+ ++ + Y RPV+I+GPL+D+IND LI E P  F SCVPHTTR K+ +EV G+DY+FV  R +ME+ I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L PI I IKP SV+++  ++ ++T  QA +  +++ +++ +   YFTAVV  D+   +Y Q+K +++  SG  IWVPT +
Sbjct:  114 TSQKRSLYVRALFDYDPMKDDGLPSRGLAFHYGDILHVTNASDDEWWQARRVLNTGDEQGMGIVPSKRRWERKQRARDRSVKFQGHMPNILEKQSTLDRKKKNFSFSRKF---PFMKSKDDKSEDGSDQEPFMLCYTQEDANAEGNEENV--LSYEPVQQMQITYTRPVIILGPLKDRINDDLISEFPEKFGSCVPHTTRPKREYEVDGRDYHFVASREQMEKDIQNHLFIEAGQYNDNLYGTSVASVREVADKGKHCILDVSGNAIKRLQVAQLFPIAIFIKPKSVESIIEMNKRMTEEQAKKTYERSLKMEQEFGEYFTAVVQGDTPEDIYEQVKEVIKEQSGPTIWVPTKE 462

HSP 2 Score: 88.1965 bits (217), Expect = 2.950e-14
Identity = 44/96 (45.83%), Postives = 63/96 (65.62%), Query Frame = 3

Query: 1590 RIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            R V+L +     G GFNIVGGED +GIF+SFI+  G AD +G +  GD+I  VNG ++  ATH+EAA  LKG+ +T+ +++     EY  FE+K +
Sbjct:    3 RTVILQKGGS--GLGFNIVGGEDGEGIFISFILAGGPADLSGELRRGDQILSVNGINLRSATHEEAAQALKGTNQTVTIVVQYRPEEYNRFEAKIH 96

HSP 3 Score: 74.7146 bits (182), Expect = 5.721e-10
Identity = 40/97 (41.24%), Postives = 53/97 (54.64%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRM 905
            V   ++ KG +G GF++ GG D         GI+++ I  GG  DLSG L   DQILSVNGIN+   THE A  ALK     + +V+Q  P   +R 
Sbjct:    2 VRTVILQKGGSGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELRRGDQILSVNGINLRSATHEEAAQALKGTNQTVTIVVQYRPEEYNRF 91

[Close]

BLAST of Disks large homolog 1 vs. TrEMBL
Match: A0A1B6I8D6 (Uncharacterized protein (Fragment) OS=Homalodisca liturata OX=320908 GN=g.40580 PE=4 SV=1)

HSP 1 Score: 300.442 bits (768), Expect = 4.490e-87
Identity = 156/367 (42.51%), Postives = 229/367 (62.40%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
            IS  +G L       ++K   YVRALF++DP  +  LPSR LAF   DI+ + N++D +WWQAR V  + E   LGI+PS  R  RK++   + V F   +     K+++L R  K  SF ++       KS  + +ED S  + +M         +E   EA   +L YEP+ ++ +DY RPV+I+GPL+D++ND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L PI + IKP SV+++  ++ ++T  QA +  ++A +++++   YFTAVV  D+   +Y ++K ++   SG  IWVP+
Sbjct:  113 ISTSTGTLLR----TSQKRSLYVRALFDYDPLKDDGLPSRGLAFHYGDILHVTNASDDEWWQARRVLWSGEQEGLGIVPSKKRWERKQRARDRTVKFQGHMPVMLDKQSTLDRKKKNFSFSRKF---PFMKSKDDKSEDGSDQEPFMLCYTQDDPSSEGTEEA---VLSYEPVSQLQIDYTRPVIILGPLKDRVNDDLISEFPDQFGSCVPHTTRPKREYEVDGRDYHFVASREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPIAVFIKPKSVESIMEMNKRMTEEQAKKTFERAMKMEAEFGEYFTAVVQGDTPEDIYQKVKEVINDQSGPTIWVPS 469

HSP 2 Score: 93.5893 bits (231), Expect = 5.303e-16
Identity = 55/130 (42.31%), Postives = 78/130 (60.00%), Query Frame = 3

Query: 1578 NKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYY 1967
            N+  R VVL++   T G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG ++  ATH+EAA  LKG+G+T+ ++      +Y  FE+K + +  +      STS  T  L  T   ++ Y
Sbjct:    6 NREVRTVVLNKG--TSGLGFNIVGGEDGEGIFVSFILAGGPADMSGELRRGDQILSVNGVNLRNATHEEAAQALKGAGQTVTIVAQYKPEDYNRFEAKIH-DLKQQMTQQISTSTGT--LLRTSQKRSLY 130

HSP 3 Score: 77.0258 bits (188), Expect = 1.055e-10
Identity = 41/91 (45.05%), Postives = 53/91 (58.24%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            V   V+ KG++G GF++ GG D         GI+V+ I  GG  D+SG L   DQILSVNG+N+   THE A  ALK AG  + +V Q  P
Sbjct:    9 VRTVVLNKGTSGLGFNIVGGEDGE-------GIFVSFILAGGPADMSGELRRGDQILSVNGVNLRNATHEEAAQALKGAGQTVTIVAQYKP 92

[Close]

BLAST of Disks large homolog 1 vs. TrEMBL
Match: A0A1B6FC97 (Uncharacterized protein (Fragment) OS=Cuerna arida OX=1464854 GN=g.37289 PE=4 SV=1)

HSP 1 Score: 295.819 bits (756), Expect = 5.894e-87
Identity = 152/353 (43.06%), Postives = 224/353 (63.46%), Query Frame = 3

Query: 2325 VTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYM---------NEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
             ++K   YVRALF++DP  +  LPSR LAF   DI+ + N++D +WWQAR V  + E   LGI+PS  R  RK++   + V F   +     K+++L R  K  SF ++       KS  + +ED S  + +M         +E   EA   +L YEP+ ++ +DY RPV+I+GPL+D++ND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I++  FIEAGQY DNLYGTS+A+VR+VA K KHC+LDV+  AIKRL  A L PI + IKP SV+++  ++ ++T  QA +  ++A +++++   YFTAVV  D+   +Y ++K ++   SG  IWVP+
Sbjct:    7 TSQKRSLYVRALFDYDPLKDDGLPSRGLAFHYGDILHVTNASDDEWWQARRVLWSGEQEGLGIVPSKKRWERKQRARDRTVKFQGHMPVMLDKQSTLDRKKKNFSFSRKF---PFMKSKDDKSEDGSDQEPFMLCYTQDDPSSEGTEEA---VLSYEPVSQLQIDYTRPVIILGPLKDRVNDDLISEFPDQFGSCVPHTTRPKREYEVDGRDYHFVASREQMERDIQNHLFIEAGQYNDNLYGTSVASVREVAEKGKHCILDVSGNAIKRLQVAQLYPIAVFIKPKSVESIMEMNKRMTEEQAKKTFERAMKMEAEFGEYFTAVVQGDTPEDIYQKVKEVINDQSGPTIWVPS 353

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Match: dlg2 (discs, large homolog 2 (Drosophila) [Source:NCBI gene;Acc:497638])

HSP 1 Score: 285.419 bits (729), Expect = 5.119e-81
Identity = 145/359 (40.39%), Postives = 223/359 (62.12%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N++D +WWQAR V  + ++  +G+IPS  R+ RKE+   K V F       N+K  S+   G  S I     G+ +  +Q   ED                 ++L YEP+++  + Y RPV+I+GP++D+IND LI E P+ F SCVPHTTR+K+ +EV G+DY+FV  R +ME+ I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A L PI I IKP S+++L  ++ ++T  QA +   +A +L+     YFTA+V  D+   +Y+Q K +++  SG  IW+P+ +
Sbjct:  560 MSSGSGSLRTNQ-----KRSLYVRALFDYERAKDSGLPSQGLSFRYGDILHVINASDDEWWQARRVTPDGDSEEMGVIPSKRRVERKERARLKTVKF-------NAKPGSIDSKGDISGIGDDGYGTKTLRSQ---ED-----------------LILSYEPVIRQEISYARPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRAKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAQLYPIAIFIKPRSIESLMEMNKRLTEEQAKKTFDRAMKLEQDFGEYFTALVQADTLEDIYTQCKMVIEEQSGPYIWIPSKE 886

HSP 2 Score: 154.066 bits (388), Expect = 1.071e-37
Identity = 108/264 (40.91%), Postives = 150/264 (56.82%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNN------VTEQFEEPFSNCQSSKDLSESLSNNDS------------PVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I L+KG +GLGFSI GG GN+H  GD  IY+TK++D GAA   G +  GD+L+ VN+Y L +VTHEEAV IL N    V LK+ KP S   ++      +T  F     N  SS   + +L    S            P  L G ++      + +D     + PR +VL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+T+ ++      EY  FE+K +
Sbjct:  293 VVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPTSVYLSDPYGPPDITHSFSPAMDNHISSAGNNGTLEYKSSLPPISPSRYSPLPRHLLGEED-----INRLDGFSFLREPRKIVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRPEEYGRFEAKIH 549

HSP 3 Score: 84.3445 bits (207), Expect = 5.471e-16
Identity = 39/87 (44.83%), Postives = 60/87 (68.97%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + +G++G GFS+AGG DNP+   +DPGI++TKI PGG+    G L ++D IL VN ++++ ++H  AV ALK AG  + L ++R
Sbjct:  200 EITLERGNSGLGFSIAGGTDNPHIG-DDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRR 285

HSP 4 Score: 78.1814 bits (191), Expect = 4.259e-14
Identity = 42/87 (48.28%), Postives = 53/87 (60.92%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + ++ Q  P
Sbjct:  459 VLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLRGATHEQAAAALKGAGQTVTIIAQYRP 538

HSP 5 Score: 70.0922 bits (170), Expect = 1.153e-11
Identity = 40/98 (40.82%), Postives = 58/98 (59.18%), Query Frame = 3

Query:  606 RPI---VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            RP+   V+E  ++KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L + D++L VN   +  +THE AV+ LK   D ++L + + PT
Sbjct:  287 RPMLETVVEIKLVKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGK-PT 382

HSP 6 Score: 65.4698 bits (158), Expect = 3.128e-10
Identity = 57/218 (26.15%), Postives = 94/218 (43.12%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H   DPGI+ITK++  GAAA  G +   D +++VN+  +++V+H  AV+ L   GS V L + +    +   V  +        +  K L  S++         G  N H                                 I G   ++ I+V+ II  G A K+G + VGDR+  VN   +   TH+EA ++LK +   + L +    + Y++
Sbjct:  220 NPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYVRRRRPMLETVVEIKL------VKGPKGLGFSIA--------GGVGNQH---------------------------------IPG---DNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYTLEEVTHEEAVAILKNTADVVYLKVGKPTSVYLS 387

HSP 7 Score: 55.8398 bits (133), Expect = 3.080e-7
Identity = 32/85 (37.65%), Postives = 46/85 (54.12%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED------EDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D      + GIF++ IIP G A ++G + V D I +VN  D+S  +H  A   LK +G  + L +
Sbjct:  201 ITLERGNS--GLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDVSEVSHSRAVEALKVAGSIVRLYV 283

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 276.944 bits (707), Expect = 3.012e-78
Identity = 139/357 (38.94%), Postives = 227/357 (63.59%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++   +++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI+I IKP S++AL  ++ + T  QA++   KA +L+ +   +FTA+V  DS   +Y++IK I++  SG  IW+P+++
Sbjct:  512 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVESEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVASREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPISIFIKPKSIEALMEMNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLEEIYNKIKLIIEEQSGPYIWIPSSE 860

HSP 2 Score: 140.584 bits (353), Expect = 2.035e-33
Identity = 99/260 (38.08%), Postives = 148/260 (56.92%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIF---------FDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            I+ ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+ +L DV HEEAV  L N    V LK+ KP      ++ + +  P  +      +   +S+N S   + G +    ++         +  V  + +      + PR V+L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  238 ILEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAKPGP---VHLNDMYAPPDYSSTFPTMVDNHVSHNSSMAYMGGMEPK-PVYQPPQVTPSRYSPVPRHMLGEDDFTREPRKVLLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRPEEYSRFESKIH 491

HSP 3 Score: 93.2041 bits (230), Expect = 8.360e-19
Identity = 40/87 (45.98%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E ++ +G++G GFS+AGGIDNP+   +DPGI++TKI PGG+  + G L ++D +L VN ++++ + H  AV ALKEAG  + L+++R
Sbjct:  145 EIILERGNSGLGFSIAGGIDNPHIP-DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLVRR 230

HSP 4 Score: 77.411 bits (189), Expect = 6.743e-14
Identity = 40/89 (44.94%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + ++ Q  P
Sbjct:  399 KVLLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRP 480

HSP 5 Score: 72.4034 bits (176), Expect = 2.455e-12
Identity = 37/89 (41.57%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L   D++L+VN I +  + HE AV+ALK   D ++L + +
Sbjct:  238 ILEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAK 325

HSP 6 Score: 58.151 bits (139), Expect = 5.162e-8
Identity = 32/85 (37.65%), Postives = 46/85 (54.12%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            ++L R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D+S   H  A   LK +G  + LL+
Sbjct:  146 IILERGNS--GLGFSIAGGIDNPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLV 228

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 275.789 bits (704), Expect = 3.057e-78
Identity = 139/357 (38.94%), Postives = 227/357 (63.59%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++   +++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI+I IKP S++AL  ++ + T  QA++   KA +L+ +   +FTA+V  DS   +Y++IK I++  SG  IW+P+++
Sbjct:  468 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVESEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVASREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPISIFIKPKSIEALMEMNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLEEIYNKIKLIIEEQSGPYIWIPSSE 816

HSP 2 Score: 140.198 bits (352), Expect = 2.204e-33
Identity = 99/260 (38.08%), Postives = 148/260 (56.92%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIF---------FDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            I+ ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+ +L DV HEEAV  L N    V LK+ KP      ++ + +  P  +      +   +S+N S   + G +    ++         +  V  + +      + PR V+L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  194 ILEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAKPGP---VHLNDMYAPPDYSSTFPTMVDNHVSHNSSMAYMGGMEPK-PVYQPPQVTPSRYSPVPRHMLGEDDFTREPRKVLLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRPEEYSRFESKIH 447

HSP 3 Score: 93.2041 bits (230), Expect = 9.222e-19
Identity = 40/87 (45.98%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E ++ +G++G GFS+AGGIDNP+   +DPGI++TKI PGG+  + G L ++D +L VN ++++ + H  AV ALKEAG  + L+++R
Sbjct:  101 EIILERGNSGLGFSIAGGIDNPHIP-DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLVRR 186

HSP 4 Score: 77.411 bits (189), Expect = 7.106e-14
Identity = 40/89 (44.94%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + ++ Q  P
Sbjct:  355 KVLLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRP 436

HSP 5 Score: 72.0182 bits (175), Expect = 2.642e-12
Identity = 37/89 (41.57%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L   D++L+VN I +  + HE AV+ALK   D ++L + +
Sbjct:  194 ILEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAK 281

HSP 6 Score: 58.151 bits (139), Expect = 5.462e-8
Identity = 32/85 (37.65%), Postives = 46/85 (54.12%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            ++L R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D+S   H  A   LK +G  + LL+
Sbjct:  102 IILERGNS--GLGFSIAGGIDNPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLV 184

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Match: dlg3 (discs, large homolog 3 (Drosophila) [Source:ZFIN;Acc:ZDB-GENE-050208-93])

HSP 1 Score: 276.174 bits (705), Expect = 3.697e-78
Identity = 139/357 (38.94%), Postives = 227/357 (63.59%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI ++   +++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI+I IKP S++AL  ++ + T  QA++   KA +L+ +   +FTA+V  DS   +Y++IK I++  SG  IW+P+++
Sbjct:  493 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIVQELVESEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVASREQMEKDIQDNKFIEAGQFNENLYGTSILSVRAVAERGKHCILDVSGNAIKRLQQAQLYPISIFIKPKSIEALMEMNKRQTYEQANKVFDKAMKLEQEFGEFFTAIVQGDSLEEIYNKIKLIIEEQSGPYIWIPSSE 841

HSP 2 Score: 140.198 bits (352), Expect = 2.329e-33
Identity = 99/260 (38.08%), Postives = 148/260 (56.92%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIF---------FDEVDSNFIN-----KSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            I+ ++L+KG +GLGFSI GG GN+H  GD  IYITK+++ GAA   G +  GD+L+ VN+ +L DV HEEAV  L N    V LK+ KP      ++ + +  P  +      +   +S+N S   + G +    ++         +  V  + +      + PR V+L +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GDRI  VNG ++  ATH++AA+ LK +G+T+ ++      EY  FESK +
Sbjct:  219 ILEVNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAKPGP---VHLNDMYAPPDYSSTFPTMVDNHVSHNSSMAYMGGMEPK-PVYQPPQVTPSRYSPVPRHMLGEDDFTREPRKVLLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRPEEYSRFESKIH 472

HSP 3 Score: 93.2041 bits (230), Expect = 8.411e-19
Identity = 40/87 (45.98%), Postives = 64/87 (73.56%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E ++ +G++G GFS+AGGIDNP+   +DPGI++TKI PGG+  + G L ++D +L VN ++++ + H  AV ALKEAG  + L+++R
Sbjct:  126 EIILERGNSGLGFSIAGGIDNPHIP-DDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLVRR 211

HSP 4 Score: 77.411 bits (189), Expect = 6.941e-14
Identity = 40/89 (44.94%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + ++ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   D+ILSVNG+N+   THE A +ALK AG  + ++ Q  P
Sbjct:  380 KVLLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQTVTIIAQYRP 461

HSP 5 Score: 72.4034 bits (176), Expect = 2.488e-12
Identity = 37/89 (41.57%), Postives = 54/89 (60.67%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            ++E  +LKG  G GFS+AGGI N +    D  IY+TKI  GG+    G L   D++L+VN I +  + HE AV+ALK   D ++L + +
Sbjct:  219 ILEVNLLKGPKGLGFSIAGGIGNQHIP-GDNSIYITKIIEGGAAQKDGRLQTGDRLLAVNNIILQDVRHEEAVAALKNTSDMVYLKVAK 306

HSP 6 Score: 58.151 bits (139), Expect = 5.573e-8
Identity = 32/85 (37.65%), Postives = 46/85 (54.12%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGG------EDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            ++L R N   G GF+I GG       D+ GIF++ IIP G A  +G + V D + +VN  D+S   H  A   LK +G  + LL+
Sbjct:  127 IILERGNS--GLGFSIAGGIDNPHIPDDPGIFITKIIPGGAAAMDGRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGPVVRLLV 209

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Match: ENSAMXT00000041203.1 (discs large homolog 1-like protein [Source:NCBI gene;Acc:103032064])

HSP 1 Score: 275.018 bits (702), Expect = 6.811e-78
Identity = 138/340 (40.59%), Postives = 211/340 (62.06%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWV 3344
            ++K   YVRALF++D   +  LPS+ L F   DI+ +VN++D +WWQAR V    E+  LG+IPS  R+ +KE+   K V F+S+   K   ++ L                +SK  +++T + S ++      +      +L YEP+ +  ++Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR K+ +EV G+DY+FV  R +ME  I+  +FIEAGQY ++LYGTS+ +VR+VA K KHC+LDV+  AIKRL  A L PI I IKP SV+ +  ++ ++T  Q  +   +A +L+ + + +FTA+V  D+   +Y Q+K I++  SG  IWV
Sbjct:  495 SQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVVNASDDEWWQARQVTAEGEDEELGVIPSKRRVEKKERARLKTVKFNSKSRDKGENQDDL----------------LSKGQKHVTSNASDSES----SYRGQEEYVLSYEPVCQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVVSREQMERDIQDHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQVALLYPIAIFIKPKSVENIMEMNRRLTEEQGRKTYDRAMKLEQEFTEHFTAIVQGDTLEEIYDQVKQIIEEQSGPFIWV 814

HSP 2 Score: 146.747 bits (369), Expect = 1.785e-35
Identity = 106/258 (41.09%), Postives = 145/258 (56.20%), Query Frame = 3

Query: 1137 RIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNN------VTEQFEEPFSNCQS-----SKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            ++V I L+KG +GLGFSI GG GN+H  GD  IY+TK+++ GAA   G +  GDKL+ VN   L +VTHE AV  L N    V LK+ KPNS   N+      +T  + +   N  S     S+ L  + S   SP     S    D+          ++ PR VVL R     G GFNIVGGED +GIF+SFI+  G AD +G +  GDR+  VNG D+  ATH++AA+ LK +G+T+ ++      EY  FE+K +
Sbjct:  230 KVVEIKLVKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKLMAVNSACLEEVTHEHAVTALKNTTDVVYLKVAKPNSVFMNDSFAPPDITNSYSQHMENHISPPNFLSQPLPPAPSGRFSPTP-KPSHGEEDL----------SREPRKVVLHR--GATGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRLVSVNGVDLRSATHEQAAAALKNAGQTVTIVAHYRPEEYSRFEAKIH 474

HSP 3 Score: 84.3445 bits (207), Expect = 4.210e-16
Identity = 42/109 (38.53%), Postives = 66/109 (60.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRM---------SGLGY 920
            E  + +G++G GFS+AGG DNP+    DP I++TK+ PGG+    G L ++D IL VN +++  +TH  AV ALKEAG  + L ++R  ++  ++          GLG+
Sbjct:  138 EITLERGNSGLGFSIAGGTDNPHIG-EDPSIFITKVIPGGAAAQDGRLQVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKSVSEKVVEIKLVKGPKGLGF 245

HSP 4 Score: 71.633 bits (174), Expect = 3.565e-12
Identity = 37/89 (41.57%), Postives = 55/89 (61.80%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            V+E  ++KG  G GFS+AGG+ N +    D  IYVTKI  GG+    G L I D++++VN   +  +THE AV+ALK   D ++L + +
Sbjct:  231 VVEIKLVKGPKGLGFSIAGGVGNQHIP-GDNSIYVTKIIEGGAAHKDGRLQIGDKLMAVNSACLEEVTHEHAVTALKNTTDVVYLKVAK 318

HSP 5 Score: 70.0922 bits (170), Expect = 9.912e-12
Identity = 35/87 (40.23%), Postives = 52/87 (59.77%), Query Frame = 3

Query:  627 VILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            V+ +G+TG GF++ GG D         GI+++ I  GG  DLSG L   D+++SVNG+++   THE A +ALK AG  + +V    P
Sbjct:  384 VLHRGATGLGFNIVGGEDGE-------GIFISFILAGGPADLSGELRKGDRLVSVNGVDLRSATHEQAAAALKNAGQTVTIVAHYRP 463

HSP 6 Score: 64.6994 bits (156), Expect = 4.818e-10
Identity = 58/199 (29.15%), Postives = 85/199 (42.71%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLK 1802
            N H   DP I+ITKV+  GAAA  G +   D +++VN+  + DVTH +AV+ L   GS V L + +  S VS  V E         +  K L  S++         G  N H                                 I G   ++ I+V+ II  G A K+G + +GD++  VN   +   TH+ A + LK
Sbjct:  158 NPHIGEDPSIFITKVIPGGAAAQDGRLQVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYVRRRKS-VSEKVVE-----IKLVKGPKGLGFSIA--------GGVGNQH---------------------------------IPG---DNSIYVTKIIEGGAAHKDGRLQIGDKLMAVNSACLEEVTHEHAVTALK 306

HSP 7 Score: 52.373 bits (124), Expect = 2.924e-6
Identity = 32/85 (37.65%), Postives = 46/85 (54.12%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED-----ED-GIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D     ED  IF++ +IP G A ++G + V D I +VN  D+   TH +A   LK +G  + L +
Sbjct:  139 ITLERGNS--GLGFSIAGGTDNPHIGEDPSIFITKVIPGGAAAQDGRLQVNDVILRVNEVDVRDVTHSKAVEALKEAGSLVRLYV 221

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Match: mpp7a (membrane protein, palmitoylated 7a (MAGUK p55 subfamily member 7) [Source:NCBI gene;Acc:30166])

HSP 1 Score: 134.42 bits (337), Expect = 6.543e-33
Identity = 102/363 (28.10%), Postives = 172/363 (47.38%), Query Frame = 3

Query: 2319 DSVTRKNGFYVRALFEFDPDVEKNLPSRP--LAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKK--NSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDT---LIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALC------------NLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVP 3347
            +S ++    Y+R  F+++P  +  +P +   L FL  +++ +V+  D  WWQA+  E +N     G+IPS + +   E+R   +      +V K+SK   + L R+ + S   R       K+++ + E K  A+   +E  T   ++   ++P      D  R +V++GP    IN+    LI   P+L++  VP TTR KK  E   K+YYFV  R   E  + +  F+E G++K NLYGTS+ A+R V    K C+LDV+  AIK +      P  I +KPPS++ L             N +   T       +  A  ++++  + F   V  D     Y ++++         +WVP
Sbjct:  223 ESQSKDTKIYLRTFFDYNPRGDVAIPCKEAGLPFLRGEVLQVVSQDDSMWWQAKRTEQSNMRA--GLIPSKHYM---ERRLAARQPASPPIVQKSSKSRLSGLRRSFRLSRQSR-------KTSKLMYESKRSAEYDASEVSTYEEVLQYQHQPG-----DKYRVIVLVGPPGVGINELKRRLIASDPSLYSGTVPTTTRQKKSHEKDSKEYYFV-SRHLFEADLHNNRFVEYGEFKGNLYGTSVDAIRSVVNAGKVCLLDVSPPAIKSIRTPEFKPFVIFVKPPSLERLRQTRGAAKSSGDKNPARNFTDEDFQEMLGTAARMEAQFGYLFDKTVVNDELAAAYRELRAAADSLERETMWVP 567

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008482.1 (pep scaffold:Pmarinus_7.0:GL477324:4663:37503:1 gene:ENSPMAG00000007666.1 transcript:ENSPMAT00000008482.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 124.79 bits (312), Expect = 6.674e-30
Identity = 92/353 (26.06%), Postives = 164/353 (46.46%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPSRP--LAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLM-LLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKAL---------CNLSSK-ITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
             +V+  F+++P  ++ +P +   L F   D++ IV+  DPDWWQA   +D    G  G++PS     +++   ++++NF S                           S       +   K     YM+ K  E +   +L YE + K+     + +V+IG     R  + + L+   P+ +   +P T+R  +  E  G+ Y+FV  R++ME  IK   ++E+G+Y+ NLYGT I ++  V   K C+LDVN  A+K L  A  +P  + I  PSV+ L           L++K +T A   + V ++  +Q    HYF   +  D+ +  ++ +++ ++       WVP  
Sbjct:  231 LFVKCQFDYNPADDQLIPCKEAGLKFSQGDVLQIVSQDDPDWWQACKAQDG---GSAGLVPSQTLEEKRKAYVRQEMNFTS--------------------------ASGGALCGVLGGKKKKKLMYMSTKNAEFDRHEILIYEEMAKMPPFQRKTLVLIGAQGVGRRSLKNRLLVSEPSRYGMTIPFTSRRPRDDEKDGQGYHFVA-RADMEVDIKSGRYLESGEYEGNLYGTKIESIGVVRAGKMCILDVNPQALKLLRTAEFMPYVVFIAAPSVEILRSMHKAALDAGLTAKHLTDADLKKTVDESTRIQRAYIHYFDLTIVNDNMDEAFANLRAYLERLVKEPQWVPIG 553

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004699.1 (pep scaffold:Pmarinus_7.0:GL501143:686031:770336:1 gene:ENSPMAG00000004247.1 transcript:ENSPMAT00000004699.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 121.324 bits (303), Expect = 3.201e-29
Identity = 90/353 (25.50%), Postives = 170/353 (48.16%), Query Frame = 3

Query: 2346 YVRALFEFDPDVEKNLPSR--PLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLM-LLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNL----------SSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
            +V+  F+++P+ ++ +P +   L F   DI+ IV+  DPDWWQA  V+D    G  G+IPS  +   ++++   +  +D   VS           G+  F               +   K     YM+ K  E +   +L YE + K+     + +++IG     R  + + L+  +P+ +   VP T+R  +  E  G+ YYFV  R++ME  I+   ++E+G+Y+ NLYGT I ++  V +  K C+LDVN  A+K L  A  +P  + +  P+++ L  +          S  +T     + V ++  +Q   SH+F   +  ++ +  ++++++ ++       WVP +
Sbjct:  137 FVKCYFDYNPEDDQLIPCKEAGLRFNRGDILQIVSQEDPDWWQALKVKD---GGSAGLIPS--QTLEEKRKAYVRHEWDYTGVS-----------GERGF------------CGVLGGKKKKKMMYMSTKNAEFDRHEILIYEEVAKMPPFQRKTLMLIGAQGVGRRSLKNRLLVANPSRYGMIVPFTSRPPRDDEKEGQGYYFVS-RADMEADIRAGRYLESGEYEGNLYGTKIESIHGVVRTGKMCILDVNPQALKVLRTAEFMPFVVFVAAPTLETLRAMHRAALDAGATSKHLTDTDLKKTVDESVRIQRAYSHFFDLKIVNNNMDVAFAKLRAALEGLGKGPQWVPIS 460

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008487.1 (pep scaffold:Pmarinus_7.0:GL477324:4663:37503:1 gene:ENSPMAG00000007666.1 transcript:ENSPMAT00000008487.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 122.479 bits (306), Expect = 4.104e-29
Identity = 92/353 (26.06%), Postives = 163/353 (46.18%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPSRP--LAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLM-LLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKAL---------CNLSSK-ITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
             +V+  F+++P  ++ +P +   L F   D++ IV+  DPDWWQA   +D    G  G++PS     +++   ++++NF S                           S       +   K     YM+ K  E +   +L YE + K+     + +V+IG     R  + + L+   P+ +   +P T+R  +  E  G+ Y+FV  R++ME  IK   ++E+G+Y+ NLYGT I +   V   K C+LDVN  A+K L  A  +P  + I  PSV+ L           L++K +T A   + V ++  +Q    HYF   +  D+ +  ++ +++ ++       WVP  
Sbjct:  217 LFVKCQFDYNPADDQLIPCKEAGLKFSQGDVLQIVSQDDPDWWQACKAQDG---GSAGLVPSQTLEEKRKAYVRQEMNFTS--------------------------ASGGALCGVLGGKKKKKLMYMSTKNAEFDRHEILIYEEMAKMPPFQRKTLVLIGAQGVGRRSLKNRLLVSEPSRYGMTIPFTSRRPRDDEKDGQGYHFVA-RADMEVDIKSGRYLESGEYEGNLYGTKIESHGVVRAGKMCILDVNPQALKLLRTAEFMPYVVFIAAPSVEILRSMHKAALDAGLTAKHLTDADLKKTVDESTRIQRAYIHYFDLTIVNDNMDEAFANLRAYLERLVKEPQWVPIG 539

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Match: MPP5 (membrane palmitoylated protein 5 [Source:HGNC Symbol;Acc:HGNC:18669])

HSP 1 Score: 103.605 bits (257), Expect = 4.365e-25
Identity = 66/187 (35.29%), Postives = 105/187 (56.15%), Query Frame = 3

Query: 2748 MLLYYEPLVKISLDYVRPVVIIGP---LRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKIT---------VAQADREV-KKAEELQSKISHYFTAVV 3266
            M LY++P      +  RP+V+IGP    R+++   L++   + FA+  PHTTR  +  EV G+DY+FV  R   E  I   +FIE G+++ NLYGTSI +VR V    K CVL+++  ++K L  ++L P  I + PPS + L  + +K +         + +  REV +KA E++    HYF  ++
Sbjct:   31 MALYHQPA-----NRKRPIVLIGPPNCGRNELRTRLMESDADRFAAATPHTTRGMRDNEVDGRDYHFVS-RQAFEADIGVHKFIEHGEFEKNLYGTSIDSVRQVINSGKICVLNLHTQSLKLLKNSDLKPYIIFVAPPSQERLRAMMAKESKNPKVSARFLPEELREVIEKAREMEQGYGHYFDGII 211

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Yeast
Match: GUK1 (Guanylate kinase; converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins [Source:SGD;Acc:S000002862])

HSP 1 Score: 83.9593 bits (206), Expect = 6.212e-19
Identity = 51/128 (39.84%), Postives = 74/128 (57.81%), Query Frame = 3

Query: 2796 RPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITIL-IKPPSVKAL 3164
            RP+VI GP    +  +   L  E+P+ F   V  TTR+ +  EV+GKDY FV    E +  IK+ EFIE  Q+  N YG+++A+V+ V+K  K C+LD++   +K + A   L    L I PPSV+ L
Sbjct:    3 RPIVISGPSGTGKSTLLKKLFAEYPDSFGFSVSSTTRTPRAGEVNGKDYNFV-SVDEFKSMIKNNEFIEWAQFSGNYYGSTVASVKQVSKSGKTCILDIDMQGVKSVKAIPELNARFLFIAPPSVEDL 129

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Match: EDO46060 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RR66])

HSP 1 Score: 274.248 bits (700), Expect = 7.636e-83
Identity = 146/360 (40.56%), Postives = 215/360 (59.72%), Query Frame = 3

Query: 2304 LTSDKDSVTR-KNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNF----DSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSY---ADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +TS++  VT  K   YVRALF++D   +  LPS+ L+F   DI+ + N++D +WWQAR +    E    G+IPS  R+ R+EK   K V F    D +L    +      R     F K++         +    D SY   A +  +     A   +L YE + +  L Y RPV+++GPL+D+IND LI E P+ F SCVPHTTR ++ +E  G DY+FV+ R EME  I++  FIEAGQY DNLYGTS+ +V+ VA K KHC+LDV+  AIKRL  A L PI I IKP S++++  L+ ++T  QA +   +A +L+ +   YFTA+V  D+++ LY+++K +++  SG  IWVP+ +
Sbjct:    3 VTSNQGVVTSVKRQLYVRALFDYDKTKDSGLPSQGLSFKYGDILHVTNASDDEWWQARKLNAVGEEEGRGVIPSKRRVERREKARMKSVKFTRTSDDKLRGSFNDGTGSVRKRSFKFSKKLPFFKKESDLETSDVDPSYTSNASDSESSTSARAEEPILSYEAVQQHELKYTRPVIVLGPLKDRINDDLISEFPDKFGSCVPHTTRPRRDYEKDGLDYHFVESREEMERAIQNHMFIEAGQYNDNLYGTSVESVKIVAEKSKHCILDVSGYAIKRLQVAGLYPIAIFIKPKSMESIRELNKRLTEEQAQKTFDRALKLEQEFGEYFTAIVQGDTYDELYNRVKEVIRQQSGPVIWVPSKE 362

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Match: EDO33577 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SRU3])

HSP 1 Score: 145.976 bits (367), Expect = 2.944e-36
Identity = 113/364 (31.04%), Postives = 184/364 (50.55%), Query Frame = 3

Query: 2322 SVTRKNGFYVRALFEFDPDVEKNLPSRPL--AFLTNDIILIVNSADPDWWQA-RVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYE-PLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPS---VKALCN-----LSSKITVAQADRE----VKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
            +++R    +VRA F++DP  ++ +P R L  AF   DI+ +V+  D +WWQA R  E+  +    G+IPS +   ++E   K  V  D++  ++ SKK           IKR +   +  +AQ             NE F E + +L Y E  L+  +    RP+V+IGP    R ++   LI   P+ FA  +PHT+R  KP E++  DY+FV   + + + + H+ F+E G+ +D+ YGTS  A++ V    K C+L+++  A+K L A+N+ P  I I  PS   V+AL        + K+ VA  DRE    V KA E++    HYF   +    F   + +++ ++        WVP +
Sbjct:  281 TLSRDRAVHVRANFDYDPYDDEFIPCRELGLAFRRGDILHVVDQEDQNWWQAWRAGEEGKKLA--GLIPSKHFQQQRESM-KHTVPADNEKTTEKSKKCLC--------IKRKRRKKVLYNAQQ------------NEVF-EVDQVLTYDEVDLLHPNPSRKRPIVLIGPPKIGRKELRQRLIQYDPDRFAGAIPHTSRPIKPGEINDHDYHFVPRHTFVTDIVAHK-FVEHGELQDHFYGTSFDAIKMVINAGKTCILNLHCEALKTLRASNIKPYVIFISSPSYERVRALRRGKIDPFNPKLNVALTDREIHEMVAKAREMEEAYGHYFDHTITNTDFERTFDELRQVIARLEDEPQWVPVS 619

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Match: EDO37538 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFE0])

HSP 1 Score: 132.494 bits (332), Expect = 2.711e-32
Identity = 98/352 (27.84%), Postives = 167/352 (47.44%), Query Frame = 3

Query: 2346 YVRALFEFDPDVEKNLPSR--PLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPL---RDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSK------ITVAQADREVKK----AEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
            +VRA F++DP  +  +P +   LAF   +++ IV+  D +WWQA+ V+D+      GIIPS      + +   KK    S+ +  + KK  +                M KS++N   +K                 L  YE + K+     + +V+IG     R  + + LI      F + +PHT+R  +  E  G+ Y+FV  R EME  I+  +++E G+Y  N+YGT I  +R+V +  K CV+DVN  A+K L     +P  + I  PS + L    SK      +   ++D E++K    +E L +  +HYF   +  D+    ++++++ ++  S    WVP +
Sbjct:  193 FVRAHFDYDPSKDDQIPCQDAGLAFKQGEVLQIVDQEDANWWQAKKVDDSR---AAGIIPS-QICEERRRAGVKKDKPGSKFLCGSKKKQKV----------------MYKSSKNFDFEKHE---------------LPIYEEVAKMPPFQRKTLVMIGAQGVGRRTLKNKLIMSDRKRFGTTIPHTSRQMREGEQSGRGYFFV-SREEMERDIRAGKYLEFGEYGGNMYGTKIDTIREVMRSGKMCVVDVNPTALKVLKTPEFMPYIVCIASPSFEELKEFQSKALSEGIVNKKRSDDELRKTVEDSERLYNSYAHYFDLTIANDNVEEAFNKLQNAIESLSTHPQWVPVS 508

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Match: EDO37539 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFE1])

HSP 1 Score: 101.679 bits (252), Expect = 1.699e-24
Identity = 58/191 (30.37%), Postives = 99/191 (51.83%), Query Frame = 3

Query: 2814 GPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSK------ITVAQADREVKK----AEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTN 3353
            G  R  + + LI      F + +PHT+R  +  E  G+ Y+FV  R EME  I+  +++E G+Y  N+YGT I  +R+V +  K CV+DVN  A+K L     +P  + I  PS + L    SK      +   ++D E++K    +E L +  +HYF   +  D+    ++++++ ++  S    WVP +
Sbjct:    4 GVGRRTLKNKLIMSDRKRFGTTIPHTSRQMREGEQSGRGYFFV-SREEMERDIRAGKYLEFGEYGGNMYGTKIDTIREVMRSGKMCVVDVNPTALKVLKTPEFMPYIVCIASPSFEELKEFQSKALSEGIVNKKRSDDELRKTVEDSERLYNSYAHYFDLTIANDNVEEAFNKLQNAIESLSTHPQWVPVS 193

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Match: EDO47352 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMI8])

HSP 1 Score: 104.76 bits (260), Expect = 5.914e-23
Identity = 84/291 (28.87%), Postives = 146/291 (50.17%), Query Frame = 3

Query: 2349 VRALFEFDPDVEKNLPSRP--LAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDT-LIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVA-QADR 3206
            +RALF +DP  +  +P +   L  +  DI+ +V+  DP+WWQAR  ++++ N  +G++PS       ++  +K+  FD       + K+S   +G  + +K  +     K    +++  +  DE      T+ +  L Y E            V +  P+ DK     LID            T+R  +P+E +G++YYFV  R+ ME   ++ +FIE G+++  LYGTS+ +++ V +  K C+L V   A K L      P  + IKPPS++ L   S+++TV  ++DR
Sbjct:  242 LRALFNYDPANDDLIPCKEAGLPLVKGDILQVVSREDPNWWQAR--KEDDVNNTIGLVPS-------KQFQEKRFLFDRLFAETENHKHS---SGGVNHVKNFRWRKRKKKEHKLSD--AQKDE------TDGDKALTYEE------------VTMFSPVNDKHRLVILID------------TSRRMRPYEANGREYYFV-SRTTMENYAQNSKFIEYGEFRKCLYGTSVDSIKRVIRTGKMCILKVQPKAAKILRRKEYKPYFVYIKPPSLETL--RSTRVTVKNKSDR 485

HSP 2 Score: 61.6178 bits (148), Expect = 1.640e-9
Identity = 38/159 (23.90%), Postives = 75/159 (47.17%), Query Frame = 3

Query: 2874 SCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVP 3347
            + +  T+R  +P+E +G++YYFV  R+ ME   ++ +FIE G+++  LYGTS+ +++ V +  K C+L V                      P  + L ++            +K  E L+ +  H F   +  D  +  ++Q+++ +   +   +WVP
Sbjct:  507 AVLQDTSRRMRPYEANGREYYFV-SRTTMENYAQNSKFIEYGEFRKCLYGTSVDSIKRVIRTGKMCILKVQ---------------------PKDEDLHDM------------IKAGEVLEQEYGHVFDLTIVNDDLDNAFNQLRNALNRVATQPMWVP 631

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 285.419 bits (729), Expect = 7.799e-82
Identity = 142/360 (39.44%), Postives = 230/360 (63.89%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N+AD +WWQAR V  + ++  +G+IPS  R+ RK++   K V F+++L S +S+ +    + K  +F ++       +  Q+ ++ +   DE            +L YE +++  +DY RPV+I+GP++D+IN+ LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME  I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A+L PI I IKP SV++L +++ +++  QA +   +A +L+ +   +FTA+V  DS   +Y+Q K +++ NSG  IW+P  +
Sbjct:  443 MSSGSGSLRTNQ-----KKSLYVRALFDYEKSKDSGLPSQGLSFRYGDILHVINAADDEWWQARRVTLHGDSEEMGVIPSKRRVERKDRARLKTVKFNAKLGSSDSRASFTDTHKKNFTFTRKFPFYKNKEDEQDGSDSQRNKDE-----------GILSYESVLRQEIDYARPVIILGPMKDRINEDLISEFPDKFGSCVPHTTRQRRDGEVDGRDYHFVTSREQMERDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAHLFPIAIFIKPKSVESLLDMNKRLSEEQARKMFDRAMKLEQEFGEFFTAMVQGDSLEDMYNQCKQVIEENSGPYIWIPAKE 786

HSP 2 Score: 125.561 bits (314), Expect = 6.328e-29
Identity = 108/303 (35.64%), Postives = 153/303 (50.50%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------GVSNNVTEQFEEPFSNCQSS----------KDLSESLSNNDSPV--RLNGSD-------------NNH--------DIFFDEVDSNFINKSP-----------------RIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I + KG +GLGFSI GG GN+H  GD  I+ITK++D GAA   G +  GD+L+ VN+  + DV+HE+AV IL +  ++V LK+ KP         G+S NV   F     +  SS           DL  +   + S +  RL   D             N H          F  + + + ++ SP                 R VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+ + +       EY  FE+K +
Sbjct:  133 VVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLSDSYGLS-NVKRSFSPTMESLTSSPIIFRTPDFRSDLCSASPTSHSHLNMRLQDEDEISRPPEPVYSTVNKHCEKAPSPRHSFPADFNQSPVHSSPQPNCHLNPLPDPNAREPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRPEEYSRFEAKIH 432

HSP 3 Score: 87.4261 bits (215), Expect = 5.203e-17
Identity = 41/87 (47.13%), Postives = 58/87 (66.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + + ++G GFS+AGG DNP+F   DPGIY+TKI PGG+    G L ++D IL VN  ++  ++H  AV ALK AG  +HL ++R
Sbjct:   40 EITLERSNSGLGFSIAGGTDNPHFG-EDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRR 125

HSP 4 Score: 77.0258 bits (188), Expect = 9.051e-14
Identity = 42/89 (47.19%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + +  Q  P
Sbjct:  340 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRP 421

HSP 5 Score: 66.6254 bits (161), Expect = 1.425e-10
Identity = 36/92 (39.13%), Postives = 56/92 (60.87%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            V+E  I KG  G GFS+AGG+ N +    D  I++TKI  GG+    G L++ D++L VN  ++  ++HE AV+ LK   +E+ L + + PT
Sbjct:  133 VVEIKITKGPKGLGFSIAGGVGNQHLP-GDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAK-PT 222

HSP 6 Score: 63.5438 bits (153), Expect = 1.159e-9
Identity = 59/222 (26.58%), Postives = 92/222 (41.44%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK----PNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H+  DPGIYITK++  GAAA  G +   D +++VND  +  V+H +AV+ L   GS V L + +    P + V   +T          +  K L  S++         G  N H       +S FI K                                 II  G A K+G + VGDR+  VN   +   +H++A ++LK +   + L +      Y++
Sbjct:   60 NPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKIT----------KGPKGLGFSIA--------GGVGNQH---LPGDNSIFITK---------------------------------IIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLS 227

HSP 7 Score: 56.9954 bits (136), Expect = 1.039e-7
Identity = 33/85 (38.82%), Postives = 49/85 (57.65%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED-----ED-GIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D     ED GI+++ IIP G A ++G + V D I +VN  D++I +H +A   LK +G  + L +
Sbjct:   41 ITLERSNS--GLGFSIAGGTDNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYV 123

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Match: dlg3 (discs large MAGUK scaffold protein 3 [Source:NCBI gene;Acc:101169708])

HSP 1 Score: 272.322 bits (695), Expect = 1.217e-81
Identity = 139/357 (38.94%), Postives = 224/357 (62.75%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMS------KSAQNITEDKSYADEYMNEKFTEANL-------MLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            + K   YVRALF++D   +  LPS+ L+F   DI+ ++N++D +WWQAR+V  + E+  +G+IPS  R+ +KE+   K V F +        +  +  + +P  +KR +  ++S      KS +NI  ++   ++ +    +++          +L YEP+++  + Y RPV+I+GP++D++ND LI E P+ F SCVPHTTR ++  E+ G+DY+FV  R +ME+ I+  +FIEAGQ+ +NLYGTSI +VR VA + KHC+LDV+  AIKRL  A L PI I IKP S++AL  ++ + T  QA++   KA +L+     +FTA+V  DS   +Y++IK I++  SG  IW+P+++
Sbjct:   16 SEKRSLYVRALFDYDRTRDSCLPSQGLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVEKKERARLKTVKFHA--------RTGMIESNRPVKVKRKKSFNLSRKFPFYKSKENIAYEQVDPEQCLTSNTSDSESSSKGQEDTILSYEPVIRQEIHYTRPVIILGPMKDRVNDDLISEFPHKFGSCVPHTTRPRRENEMDGQDYHFVASREQMEKDIQDNKFIEAGQFNENLYGTSILSVRTVAERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNKRQTYDQANKVFDKAVKLEQDFGEFFTAIVQGDSLEEIYNKIKLIIEEQSGPYIWIPSSE 364

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 285.419 bits (729), Expect = 1.432e-81
Identity = 142/360 (39.44%), Postives = 230/360 (63.89%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N+AD +WWQAR V  + ++  +G+IPS  R+ RK++   K V F+++L S +S+ +    + K  +F ++       +  Q+ ++ +   DE            +L YE +++  +DY RPV+I+GP++D+IN+ LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME  I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A+L PI I IKP SV++L +++ +++  QA +   +A +L+ +   +FTA+V  DS   +Y+Q K +++ NSG  IW+P  +
Sbjct:  480 MSSGSGSLRTNQ-----KKSLYVRALFDYEKSKDSGLPSQGLSFRYGDILHVINAADDEWWQARRVTLHGDSEEMGVIPSKRRVERKDRARLKTVKFNAKLGSSDSRASFTDTHKKNFTFTRKFPFYKNKEDEQDGSDSQRNKDE-----------GILSYESVLRQEIDYARPVIILGPMKDRINEDLISEFPDKFGSCVPHTTRQRRDGEVDGRDYHFVTSREQMERDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAHLFPIAIFIKPKSVESLLDMNKRLSEEQARKMFDRAMKLEQEFGEFFTAMVQGDSLEDMYNQCKQVIEENSGPYIWIPAKE 823

HSP 2 Score: 125.946 bits (315), Expect = 6.069e-29
Identity = 108/303 (35.64%), Postives = 153/303 (50.50%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------GVSNNVTEQFEEPFSNCQSS----------KDLSESLSNNDSPV--RLNGSD-------------NNH--------DIFFDEVDSNFINKSP-----------------RIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I + KG +GLGFSI GG GN+H  GD  I+ITK++D GAA   G +  GD+L+ VN+  + DV+HE+AV IL +  ++V LK+ KP         G+S NV   F     +  SS           DL  +   + S +  RL   D             N H          F  + + + ++ SP                 R VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+ + +       EY  FE+K +
Sbjct:  170 VVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLSDSYGLS-NVKRSFSPTMESLTSSPIIFRTPDFRSDLCSASPTSHSHLNMRLQDEDEISRPPEPVYSTVNKHCEKAPSPRHSFPADFNQSPVHSSPQPNCHLNPLPDPNAREPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRPEEYSRFEAKIH 469

HSP 3 Score: 87.0409 bits (214), Expect = 5.994e-17
Identity = 41/87 (47.13%), Postives = 58/87 (66.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + + ++G GFS+AGG DNP+F   DPGIY+TKI PGG+    G L ++D IL VN  ++  ++H  AV ALK AG  +HL ++R
Sbjct:   77 EITLERSNSGLGFSIAGGTDNPHFG-EDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRR 162

HSP 4 Score: 76.6406 bits (187), Expect = 9.571e-14
Identity = 42/89 (47.19%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + +  Q  P
Sbjct:  377 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRP 458

HSP 5 Score: 66.6254 bits (161), Expect = 1.483e-10
Identity = 36/92 (39.13%), Postives = 56/92 (60.87%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            V+E  I KG  G GFS+AGG+ N +    D  I++TKI  GG+    G L++ D++L VN  ++  ++HE AV+ LK   +E+ L + + PT
Sbjct:  170 VVEIKITKGPKGLGFSIAGGVGNQHL-PGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAK-PT 259

HSP 6 Score: 63.5438 bits (153), Expect = 1.106e-9
Identity = 60/222 (27.03%), Postives = 92/222 (41.44%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK----PNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H+  DPGIYITK++  GAAA  G +   D +++VND  +  V+H +AV+ L   GS V L + +    P + V   +T          +  K L  S++       L G DN          S FI K                                 II  G A K+G + VGDR+  VN   +   +H++A ++LK +   + L +      Y++
Sbjct:   97 NPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKIT----------KGPKGLGFSIAGGVGNQHLPG-DN----------SIFITK---------------------------------IIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLS 264

HSP 7 Score: 60.8474 bits (146), Expect = 7.315e-9
Identity = 40/115 (34.78%), Postives = 62/115 (53.91%), Query Frame = 3

Query: 1506 SPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGED-----ED-GIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            SP+++NG +  +D  F+E+             L R N   G GF+I GG D     ED GI+++ IIP G A ++G + V D I +VN  D++I +H +A   LK +G  + L +
Sbjct:   62 SPLKVNGIETQYD--FEEI------------TLERSNS--GLGFSIAGGTDNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYV 160

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 285.419 bits (729), Expect = 2.526e-81
Identity = 142/360 (39.44%), Postives = 230/360 (63.89%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKP-SFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N+AD +WWQAR V  + ++  +G+IPS  R+ RK++   K V F+++L S +S+ +    + K  +F ++       +  Q+ ++ +   DE            +L YE +++  +DY RPV+I+GP++D+IN+ LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME  I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A+L PI I IKP SV++L +++ +++  QA +   +A +L+ +   +FTA+V  DS   +Y+Q K +++ NSG  IW+P  +
Sbjct:  498 MSSGSGSLRTNQ-----KKSLYVRALFDYEKSKDSGLPSQGLSFRYGDILHVINAADDEWWQARRVTLHGDSEEMGVIPSKRRVERKDRARLKTVKFNAKLGSSDSRASFTDTHKKNFTFTRKFPFYKNKEDEQDGSDSQRNKDE-----------GILSYESVLRQEIDYARPVIILGPMKDRINEDLISEFPDKFGSCVPHTTRQRRDGEVDGRDYHFVTSREQMERDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAHLFPIAIFIKPKSVESLLDMNKRLSEEQARKMFDRAMKLEQEFGEFFTAMVQGDSLEDMYNQCKQVIEENSGPYIWIPAKE 841

HSP 2 Score: 125.946 bits (315), Expect = 6.326e-29
Identity = 108/303 (35.64%), Postives = 153/303 (50.50%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------GVSNNVTEQFEEPFSNCQSS----------KDLSESLSNNDSPV--RLNGSD-------------NNH--------DIFFDEVDSNFINKSP-----------------RIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I + KG +GLGFSI GG GN+H  GD  I+ITK++D GAA   G +  GD+L+ VN+  + DV+HE+AV IL +  ++V LK+ KP         G+S NV   F     +  SS           DL  +   + S +  RL   D             N H          F  + + + ++ SP                 R VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+ + +       EY  FE+K +
Sbjct:  188 VVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLSDSYGLS-NVKRSFSPTMESLTSSPIIFRTPDFRSDLCSASPTSHSHLNMRLQDEDEISRPPEPVYSTVNKHCEKAPSPRHSFPADFNQSPVHSSPQPNCHLNPLPDPNAREPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRPEEYSRFEAKIH 487

HSP 3 Score: 87.4261 bits (215), Expect = 5.995e-17
Identity = 41/87 (47.13%), Postives = 58/87 (66.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + + ++G GFS+AGG DNP+F   DPGIY+TKI PGG+    G L ++D IL VN  ++  ++H  AV ALK AG  +HL ++R
Sbjct:   95 EITLERSNSGLGFSIAGGTDNPHFG-EDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRR 180

HSP 4 Score: 77.0258 bits (188), Expect = 9.376e-14
Identity = 42/89 (47.19%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + +  Q  P
Sbjct:  395 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRP 476

HSP 5 Score: 66.6254 bits (161), Expect = 1.499e-10
Identity = 36/92 (39.13%), Postives = 56/92 (60.87%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            V+E  I KG  G GFS+AGG+ N +    D  I++TKI  GG+    G L++ D++L VN  ++  ++HE AV+ LK   +E+ L + + PT
Sbjct:  188 VVEIKITKGPKGLGFSIAGGVGNQHL-PGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAK-PT 277

HSP 6 Score: 63.5438 bits (153), Expect = 1.136e-9
Identity = 60/222 (27.03%), Postives = 92/222 (41.44%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK----PNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H+  DPGIYITK++  GAAA  G +   D +++VND  +  V+H +AV+ L   GS V L + +    P + V   +T          +  K L  S++       L G DN          S FI K                                 II  G A K+G + VGDR+  VN   +   +H++A ++LK +   + L +      Y++
Sbjct:  115 NPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKIT----------KGPKGLGFSIAGGVGNQHLPG-DN----------SIFITK---------------------------------IIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLS 282

HSP 7 Score: 57.3806 bits (137), Expect = 1.013e-7
Identity = 33/85 (38.82%), Postives = 49/85 (57.65%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED-----ED-GIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D     ED GI+++ IIP G A ++G + V D I +VN  D++I +H +A   LK +G  + L +
Sbjct:   96 ITLERSNS--GLGFSIAGGTDNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYV 178

[Close]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Match: dlg2 (disks large homolog 2 [Source:NCBI gene;Acc:101168565])

HSP 1 Score: 280.026 bits (715), Expect = 1.216e-79
Identity = 142/359 (39.55%), Postives = 224/359 (62.40%), Query Frame = 3

Query: 2283 ISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVA-KLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQ 3356
            +S+GSG+L +++     K   YVRALF+++   +  LPS+ L+F   DI+ ++N+AD +WWQAR V  + ++  +G+IPS  R+ RK++   K V F+++L S +S+ + L             +G           D  Y  +    K    +  +L YE +++  +DY RPV+I+GP++D+IN+ LI E P+ F SCVPHTTR ++  EV G+DY+FV  R +ME  I+  +FIEAGQY DNLYGTS+ +V+ VA + KHC+LDV+  AIKRL  A+L PI I IKP SV++L +++ +++  QA +   +A +L+ +   +FTA+V  DS   +Y+Q K +++ NSG  IW+P  +
Sbjct:  498 MSSGSGSLRTNQ-----KKSLYVRALFDYEKSKDSGLPSQGLSFRYGDILHVINAADDEWWQARRVTLHGDSEEMGVIPSKRRVERKDRARLKTVKFNAKLGSSDSRADIL------------GIG-----------DDGYGTKISRNK----DEGILSYESVLRQEIDYARPVIILGPMKDRINEDLISEFPDKFGSCVPHTTRQRRDGEVDGRDYHFVTSREQMERDIQEHKFIEAGQYNDNLYGTSVQSVKYVAERGKHCILDVSGNAIKRLQVAHLFPIAIFIKPKSVESLLDMNKRLSEEQARKMFDRAMKLEQEFGEFFTAMVQGDSLEDMYNQCKQVIEENSGPYIWIPAKE 824

HSP 2 Score: 125.561 bits (314), Expect = 7.107e-29
Identity = 108/303 (35.64%), Postives = 153/303 (50.50%), Query Frame = 3

Query: 1140 IVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNS-------GVSNNVTEQFEEPFSNCQSS----------KDLSESLSNNDSPV--RLNGSD-------------NNH--------DIFFDEVDSNFINKSP-----------------RIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFN 1877
            +V I + KG +GLGFSI GG GN+H  GD  I+ITK++D GAA   G +  GD+L+ VN+  + DV+HE+AV IL +  ++V LK+ KP         G+S NV   F     +  SS           DL  +   + S +  RL   D             N H          F  + + + ++ SP                 R VVL +   + G GFNIVGGED +GIFVSFI+  G AD +G +  GD+I  VNG D+  ATH++AA+ LKG+G+ + +       EY  FE+K +
Sbjct:  188 VVEIKITKGPKGLGFSIAGGVGNQHLPGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLSDSYGLS-NVKRSFSPTMESLTSSPIIFRTPDFRSDLCSASPTSHSHLNMRLQDEDEISRPPEPVYSTVNKHCEKAPSPRHSFPADFNQSPVHSSPQPNCHLNPLPDPNAREPRKVVLHK--GSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRPEEYSRFEAKIH 487

HSP 3 Score: 87.0409 bits (214), Expect = 7.429e-17
Identity = 41/87 (47.13%), Postives = 58/87 (66.67%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQR 881
            E  + + ++G GFS+AGG DNP+F   DPGIY+TKI PGG+    G L ++D IL VN  ++  ++H  AV ALK AG  +HL ++R
Sbjct:   95 EITLERSNSGLGFSIAGGTDNPHFG-EDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRR 180

HSP 4 Score: 76.2554 bits (186), Expect = 1.291e-13
Identity = 42/89 (47.19%), Postives = 53/89 (59.55%), Query Frame = 3

Query:  621 EAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDP 887
            + V+ KGSTG GF++ GG D         GI+V+ I  GG  DLSG L   DQILSVNGI++   THE A +ALK AG  + +  Q  P
Sbjct:  395 KVVLHKGSTGLGFNIVGGEDGE-------GIFVSFILAGGPADLSGELRRGDQILSVNGIDLREATHEQAAAALKGAGQVVTIFAQYRP 476

HSP 5 Score: 65.855 bits (159), Expect = 1.966e-10
Identity = 36/92 (39.13%), Postives = 56/92 (60.87%), Query Frame = 3

Query:  615 VMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPT 890
            V+E  I KG  G GFS+AGG+ N +    D  I++TKI  GG+    G L++ D++L VN  ++  ++HE AV+ LK   +E+ L + + PT
Sbjct:  188 VVEIKITKGPKGLGFSIAGGVGNQHL-PGDNSIFITKIIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAK-PT 277

HSP 6 Score: 63.1586 bits (152), Expect = 1.369e-9
Identity = 59/222 (26.58%), Postives = 92/222 (41.44%), Query Frame = 3

Query: 1206 NEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILK----PNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA 1859
            N H+  DPGIYITK++  GAAA  G +   D +++VND  +  V+H +AV+ L   GS V L + +    P + V   +T          +  K L  S++         G  N H       +S FI K                                 II  G A K+G + VGDR+  VN   +   +H++A ++LK +   + L +      Y++
Sbjct:  115 NPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYVRRRRPAPETVVEIKIT----------KGPKGLGFSIA--------GGVGNQH---LPGDNSIFITK---------------------------------IIDGGAAQKDGRLHVGDRLLMVNNCSVEDVSHEDAVTILKSTSNEVFLKVAKPTQVYLS 282

HSP 7 Score: 56.9954 bits (136), Expect = 1.142e-7
Identity = 33/85 (38.82%), Postives = 49/85 (57.65%), Query Frame = 3

Query: 1596 VVLSRPNETVGFGFNIVGGED-----ED-GIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLL 1832
            + L R N   G GF+I GG D     ED GI+++ IIP G A ++G + V D I +VN  D++I +H +A   LK +G  + L +
Sbjct:   96 ITLERSNS--GLGFSIAGGTDNPHFGEDPGIYITKIIPGGAAAEDGRLKVNDCILRVNDADVAIVSHGKAVEALKVAGSVVHLYV 178

[Close]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Match: SMESG000034854.1 (SMESG000034854.1)

HSP 1 Score: 2020.36 bits (5233), Expect = 0.000e+0
Identity = 1104/1104 (100.00%), Postives = 1104/1104 (100.00%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYXXXXXXXXXXXXXXXXLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFEXXXXXXXXXXXXXGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL 3371
            MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYPSSPSSVSSSGRVGSRLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYSQPSMSNSNESSSRETNNSFNEIIDQDIDNQLINRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNSHSSVWVTSSKASSVPSNLSQGIKSSNSSFVSLKSRIVTISLIKGERGLGFSIGGGRGNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFESNTSTTNSATNHSGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL
Sbjct:    1 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYPSSPSSVSSSGRVGSRLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYSQPSMSNSNESSSRETNNSFNEIIDQDIDNQLINRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNSHSSVWVTSSKASSVPSNLSQGIKSSNSSFVSLKSRIVTISLIKGERGLGFSIGGGRGNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFESNTSTTNSATNHSGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL 1104

[Close]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Match: SMESG000034854.1 (SMESG000034854.1)

HSP 1 Score: 1989.16 bits (5152), Expect = 0.000e+0
Identity = 1092/1104 (98.91%), Postives = 1092/1104 (98.91%), Query Frame = 3

Query:   60 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALLDKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYXXXXXXXXXXXXXXXXLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNXXXXXXXXXXXXXXXPSNLSQGIKXXXXXXXXXXXRIVTISLIKXXXXXXXXXXXXXXNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFEXXXXXXXXXXXXXGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL 3371
            MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALL            EIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYPSSPSSVSSSGRVGSRLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYSQPSMSNSNESSSRETNNSFNEIIDQDIDNQLINRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNSHSSVWVTSSKASSVPSNLSQGIKSSNSSFVSLKSRIVTISLIKGERGLGFSIGGGRGNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFESNTSTTNSATNHSGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL
Sbjct:    1 MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALL------------EIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYPSSPSSVSSSGRVGSRLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYSQPSMSNSNESSSRETNNSFNEIIDQDIDNQLINRPIVMEAVILKGSTGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTISDSRQDSQAEKSSSQVSPEYIKTNSHSSVWVTSSKASSVPSNLSQGIKSSNSSFVSLKSRIVTISLIKGERGLGFSIGGGRGNEHYVGDPGIYITKVMDKGAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPNSGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVAFESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNNDHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSSKRTKTPASCDYDSRISEKENHQIFTFESNTSTTNSATNHSGISNGSGNLTSDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQNTVNL 1092

[Close]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Match: SMESG000060935.1 (SMESG000060935.1)

HSP 1 Score: 202.986 bits (515), Expect = 2.016e-55
Identity = 125/377 (33.16%), Postives = 206/377 (54.64%), Query Frame = 3

Query: 2328 TRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVV-----EDNNENGPLGIIPSPNRLYRKEKRNKKKVNF------------DSQLVSKNSKK---------NSLPR--NGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLM------LLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL-KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSK-ITVAQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT 3350
            T K   YVRALF +  + +  LP++ L+F   DI+ + N++D +WWQAR V     ED  +   LGIIPS NR+ R+ K  +KKV              D   +S +  +         NSLPR  NGK    K+   G +    +  +++K  ++    E   +  L       +  Y+P+++     +RPV+I+G  +++IN +L+ E+   F  CVPHTTR  +  ++ GKD+YFV   SEM E + + +FIE G+  + LYGTS+ ++ DVA+  KHC+LD++++AIKRL    + PITILI+  S+    +L SK ++  Q+ + + K   L+ +   + TA++   +F  +Y Q+   +  N+G  +W+P+
Sbjct:  171 TSKKTLYVRALFNYQVNKDCGLPNKGLSFKFGDILHVTNASDSEWWQARKVNLTTGEDETD---LGIIPSKNRVERQNKTKQKKVRICVDDTIPIVDENDEYTISTSLSQSVGDIKLTANSLPRPQNGKIIDCKKQTNGGLFSRFKGKSKNKCQSNSINQESENDVTLARNSTESIQSYQPVIQEENSLIRPVIILGVAKEEINKSLLKEYNEEFGVCVPHTTRPIETDDIDGKDFYFV-SVSEMNELMSNHQFIETGRSGNFLYGTSVQSIIDVAEAGKHCILDISSMAIKRLYIREIWPITILIQVQSIDDYRSLISKPVSEEQSLKALSKLSRLEQEFLPFITAIISGSNFESVYQQVIQTIAINNGRKVWLPS 543

HSP 2 Score: 75.485 bits (184), Expect = 1.342e-13
Identity = 38/101 (37.62%), Postives = 63/101 (62.38%), Query Frame = 3

Query: 1551 FDEVDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADKNGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEY 1853
            + +   + I K+ R V+L++ +++  FGFNI+GG   +GI++SFI+  G AD +  I+ GD+I +VNG DIS  TH     L+K SG  + LL+   + ++
Sbjct:   38 YSQTSDDSITKTQRQVMLTKSSDS-SFGFNIIGGTMGEGIYISFILAGGPADISKKIYKGDQILKVNGHDISNLTHSTVVQLMKESGNKINLLVIYKIEDF 137

HSP 3 Score: 56.225 bits (134), Expect = 1.232e-7
Identity = 28/77 (36.36%), Postives = 46/77 (59.74%), Query Frame = 3

Query:  645 TGFGFSVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMTYLTHEAAVSALKEAGDELHLVI 875
            + FGF++ GG           GIY++ I  GG  D+S  +   DQIL VNG +++ LTH   V  +KE+G++++L++
Sbjct:   61 SSFGFNIIGGT-------MGEGIYISFILAGGPADISKKIYKGDQILKVNGHDISNLTHSTVVQLMKESGNKINLLV 130

[Close]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Match: SMESG000045568.1 (SMESG000045568.1)

HSP 1 Score: 158.303 bits (399), Expect = 6.747e-42
Identity = 95/273 (34.80%), Postives = 149/273 (54.58%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVEDNNEN---GPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKNSLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLL-YYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKLK-HCVLDVNALAIKRLVAANLLPITILIKP 3146
            FYV+ L E++ + + +LP + L+F   +I+ I N+ D DWW AR +   N N      GIIPS NRLY+K +  +  VNF+ + +        +  NG  +  K     +   S+ ++   +  A    N   T+  + +  +YE +      + RPV+ IGP R K+ D LI  +PN+FAS V HTTR K+  E+ G DY+F++++++     +   FIE  +Y  N YGTS+ AVR+V + K HC++D     IK L   ++ PI+ILI P
Sbjct:   17 FYVKTLIEYNSESDYSLPRKGLSFEIGEILHIKNANDKDWWFARKLNPLNTNIFPSDEGIIPSANRLYKKHQNKEMSVNFEEKTII-------IESNGSQTLDKINSGSTPGSSSLDLKRKRQQATMQQNLTKTDQKMSINDFYEIVESTKSLFPRPVLAIGPGRSKLYDQLILNYPNIFASPVNHTTRPKRSNEIEGNDYHFIENKNQFNTDKEAGLFIETVEYNGNFYGTSLLAVRNVMESKRHCIIDATFTVIKNLEKNDIQPISILICP 282

[Close]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Match: SMESG000017603.1 (SMESG000017603.1)

HSP 1 Score: 150.214 bits (378), Expect = 5.929e-39
Identity = 108/365 (29.59%), Postives = 190/365 (52.05%), Query Frame = 3

Query: 2343 FYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPDWWQARVVE-------DNNENGPL----GIIPSPNRLYRKEKRNKKKVNFDSQ--LVSKNSKKNSLPRN--GKPSF-IKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLYYEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKPFEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRD-VAKLKHCVLDVNALAIKRLVAANLLPITILIKPPSV---KALCNLSSKITV-AQADREVKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPT-NQNTVNL 3371
            FY+R L  ++P ++K LP + L F   D++L++N+ D  WWQA  +        +N  N  L    G+IPS  R+  K +  K+ V FDS+  ++    K  S   N  G  SF +KR++  + S+       +KS     +   FT        YE + +  +   RP+V+IGP +D++ + L+ E+ +++ + +PHTTR  +P E  G DY+F+ ++ E+E +    ++I+ G++K N Y  SI +V+  +AK K+ +LD++   I++L +A + PI ILI   S+   K L     +I +  Q+ R+     +L+ + S  F  ++   S   L  Q+  +V     S  WV   +Q+ +N+
Sbjct:   19 FYIRTLCSYEPSLDKGLPGKGLKFKPGDLLLVINANDSQWWQAVHIRRNLFLSSNNLHNSSLSRERGLIPSLERVKNKSRFQKRHVEFDSRAMVIGPTGKLVSEIINSPGCSSFDLKRIRKFNNSRKPM----EKSICGTDLENNFTNP------YEIIEQQIIKTTRPIVVIGPGKDQLYEYLLIEYSDIYNTPIPHTTRPPRPGERDGVDYHFISNKDELESETNSSKYIDVGKFKGNFYANSIESVKQALAKSKYPLLDISHNGIEKLRSAAIYPICILISTSSLSQAKTLQGDGRQINLDVQSTRDY--TIKLEKEFSVLFDVIISPTSAAELKEQVVQLVHAYQRSPTWVAAEDQSLLNI 371

The following BLAST results are available for this feature:

BLAST of Disks large homolog 1 vs. Ensembl Human
BLAST of Disks large homolog 1 vs. Ensembl Celegans
BLAST of Disks large homolog 1 vs. Ensembl Fly
BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
BLAST of Disks large homolog 1 vs. Ensembl Xenopus
BLAST of Disks large homolog 1 vs. Ensembl Mouse
BLAST of Disks large homolog 1 vs. UniProt/SwissProt
BLAST of Disks large homolog 1 vs. TrEMBL
BLAST of Disks large homolog 1 vs. Ensembl Cavefish
BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
BLAST of Disks large homolog 1 vs. Ensembl Yeast
BLAST of Disks large homolog 1 vs. Ensembl Nematostella
BLAST of Disks large homolog 1 vs. Ensembl Medaka
BLAST of Disks large homolog 1 vs. Planmine SMEST

BLAST of Disks large homolog 1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DLG2	2.850e-84	40.11	discs large MAGUK scaffold protein 2 [Source:HGNC ...	[more]
DLG2	4.954e-84	39.83	discs large MAGUK scaffold protein 2 [Source:HGNC ...	[more]
DLG3	1.982e-83	41.14	discs large MAGUK scaffold protein 3 [Source:HGNC ...	[more]
DLG3	5.520e-82	41.14	discs large MAGUK scaffold protein 3 [Source:HGNC ...	[more]
DLG1	6.493e-82	40.99	discs large MAGUK scaffold protein 1 [Source:HGNC ...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dlg-1	3.084e-66	37.95	Disks large homolog 1 [Source:UniProtKB/Swiss-Pro...	[more]
lin-2	2.796e-25	24.79	pep chromosome:WBcel235:X:12399517:12406131:-1 gen...	[more]
lin-2	3.191e-25	24.86	pep chromosome:WBcel235:X:12399517:12414037:-1 gen...	[more]
magu-1	3.688e-20	27.21	MAGUK family [Source:UniProtKB/TrEMBL;Acc:Q95XW5]	[more]
magu-2	8.586e-20	24.43	MAGUK family [Source:UniProtKB/TrEMBL;Acc:A0A3B1D...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dlg1	2.606e-87	42.43	gene:FBgn0001624 transcript:FBtr0073490	[more]
dlg1	3.820e-87	42.43	gene:FBgn0001624 transcript:FBtr0112812	[more]
dlg1	6.389e-87	42.43	gene:FBgn0001624 transcript:FBtr0073488	[more]
dlg1	2.333e-86	42.94	gene:FBgn0001624 transcript:FBtr0333262	[more]
dlg1	1.525e-83	40.79	gene:FBgn0001624 transcript:FBtr0073485	[more]

BLAST of Disks large homolog 1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dlg3	7.402e-83	39.50	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
dlg3	7.402e-83	39.50	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
dlg3	2.382e-78	40.29	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
dlg2	1.068e-77	39.51	discs, large homolog 2 (Drosophila) [Source:NCBI g...	[more]
dlg3	1.766e-77	39.50	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
hmmr	1.194e-79	41.38	hyaluronan-mediated motility receptor (RHAMM) [Sou...	[more]
hjv	1.365e-79	39.83	hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB...	[more]
hjv	3.659e-79	39.83	hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB...	[more]
hjv	5.444e-79	39.83	hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB...	[more]
hjv	5.787e-79	39.83	hemojuvelin BMP co-receptor [Source:Xenbase;Acc:XB...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dlg2	6.506e-84	39.62	discs large MAGUK scaffold protein 2 [Source:MGI S...	[more]
Dlg3	3.395e-82	41.14	discs large MAGUK scaffold protein 3 [Source:MGI S...	[more]
Dlg2	1.180e-80	40.44	discs large MAGUK scaffold protein 2 [Source:MGI S...	[more]
Dlg2	1.647e-80	39.55	discs large MAGUK scaffold protein 2 [Source:MGI S...	[more]
Dlg2	1.826e-79	39.62	discs large MAGUK scaffold protein 2 [Source:MGI S...	[more]

BLAST of Disks large homolog 1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P31007\|DLG1_DROME	6.404e-86	42.43	Disks large 1 tumor suppressor protein OS=Drosophi...	[more]
sp\|Q15700\|DLG2_HUMAN	2.722e-79	40.44	Disks large homolog 2 OS=Homo sapiens OX=9606 GN=D...	[more]
sp\|Q91XM9\|DLG2_MOUSE	2.204e-78	39.55	Disks large homolog 2 OS=Mus musculus OX=10090 GN=...	[more]
sp\|Q12959\|DLG1_HUMAN	2.369e-78	40.99	Disks large homolog 1 OS=Homo sapiens OX=9606 GN=D...	[more]
sp\|Q63622\|DLG2_RAT	5.272e-78	39.55	Disks large homolog 2 OS=Rattus norvegicus OX=1011...	[more]

BLAST of Disks large homolog 1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C3YXG4	4.133e-88	41.97	Uncharacterized protein OS=Branchiostoma floridae ...	[more]
A0A1B6MPK7	1.231e-87	42.51	Uncharacterized protein OS=Graphocephala atropunct...	[more]
A0A482VHQ1	1.681e-87	43.22	Disks large 1 tumor suppressor protein (Fragment) ...	[more]
A0A1B6I8D6	4.490e-87	42.51	Uncharacterized protein (Fragment) OS=Homalodisca ...	[more]
A0A1B6FC97	5.894e-87	43.06	Uncharacterized protein (Fragment) OS=Cuerna arida...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dlg2	5.119e-81	40.39	discs, large homolog 2 (Drosophila) [Source:NCBI g...	[more]
dlg3	3.012e-78	38.94	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
dlg3	3.057e-78	38.94	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
dlg3	3.697e-78	38.94	discs, large homolog 3 (Drosophila) [Source:ZFIN;A...	[more]
ENSAMXT00000041203.1	6.811e-78	40.59	discs large homolog 1-like protein [Source:NCBI ge...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mpp7a	6.543e-33	28.10	membrane protein, palmitoylated 7a (MAGUK p55 subf...	[more]
ENSPMAT00000008482.1	6.674e-30	26.06	pep scaffold:Pmarinus_7.0:GL477324:4663:37503:1 ge...	[more]
ENSPMAT00000004699.1	3.201e-29	25.50	pep scaffold:Pmarinus_7.0:GL501143:686031:770336:1...	[more]
ENSPMAT00000008487.1	4.104e-29	26.06	pep scaffold:Pmarinus_7.0:GL477324:4663:37503:1 ge...	[more]
MPP5	4.365e-25	35.29	membrane palmitoylated protein 5 [Source:HGNC Symb...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
GUK1	6.212e-19	39.84	Guanylate kinase; converts GMP to GDP; required fo...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO46060	7.636e-83	40.56	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO33577	2.944e-36	31.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37538	2.711e-32	27.84	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37539	1.699e-24	30.37	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO47352	5.914e-23	28.87	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Disks large homolog 1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dlg2	7.799e-82	39.44	disks large homolog 2 [Source:NCBI gene;Acc:101168...	[more]
dlg3	1.217e-81	38.94	discs large MAGUK scaffold protein 3 [Source:NCBI ...	[more]
dlg2	1.432e-81	39.44	disks large homolog 2 [Source:NCBI gene;Acc:101168...	[more]
dlg2	2.526e-81	39.44	disks large homolog 2 [Source:NCBI gene;Acc:101168...	[more]
dlg2	1.216e-79	39.55	disks large homolog 2 [Source:NCBI gene;Acc:101168...	[more]

BLAST of Disks large homolog 1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000034854.1	0.000e+0	100.00	SMESG000034854.1	[more]
SMESG000034854.1	0.000e+0	98.91	SMESG000034854.1	[more]
SMESG000060935.1	2.016e-55	33.16	SMESG000060935.1	[more]
SMESG000045568.1	6.747e-42	34.80	SMESG000045568.1	[more]
SMESG000017603.1	5.929e-39	29.59	SMESG000017603.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019914 ID=SMED30019914|Name=Disks large homolog 1|organism=Schmidtea mediterranea sexual|type=transcript|length=3470bp
TGACATTAGTCACATTTTGAATTCGTGATATAACATTTTAAACCTTATTT
AATTAAGTTATGCCAGTTGGAAGCAGTGATGCTTTAAAAGCAATTGAACT
GTTAGAACTTTATCGTTCAAAACTCTCAGAAACATCGGATAAAAATTTAA
TCGAAGCTATCGATAAAGTGATCAATGTTTTTAATAGTCAATTTTTCATT
GCACTTCTTGATAAATCAAAAGAGGGTTTTGATTTAATAAGAAAAGAAAT
CCAAAGATTTTACATCGATATTTTATCAAACAATTACCTTTCCATATCTG
ATAAAACTCAAGAAACTCTTAATTTTTTAAACAGTTTAAAACTTTATCCA
TCCTCCCCATCTTCAGTATCCAGCAGTGGTCGCGTCGGGTCTAGATTGGC
AAATGATGTCGAGTCAATTAATATGCTCTATTCATCACTTAGGCGCAAAG
AATCACTTACTAATTCCAATATCAGTAGTCATAAAAAATATTCAAATACT
TACTCACAACCATCGATGAGTAACAGTAACGAATCATCATCACGGGAAAC
CAATAACTCATTCAATGAAATCATTGACCAGGATATTGACAACCAATTAA
TAAACCGACCAATCGTTATGGAGGCTGTGATTTTGAAGGGTTCAACTGGA
TTTGGGTTCAGTGTAGCGGGTGGAATCGACAACCCCTATTTCCATTTAAA
CGACCCAGGTATTTACGTGACAAAAATCACACCGGGAGGTTCTGTTGATT
TGAGTGGTAGTTTAAATATTGATGATCAGATCTTATCTGTGAATGGAATC
AACATGACCTATTTGACCCACGAGGCAGCTGTGTCAGCTCTGAAAGAAGC
TGGAGATGAATTACATTTGGTAATTCAGCGAGATCCGACACTTAAGCATC
GAATGTCAGGATTGGGTTATATGAGACGTAAAAATGCATCTCTAACTGCA
TCAACCATATCAGACAGTCGGCAAGATTCACAGGCCGAGAAATCAAGTTC
TCAGGTATCTCCTGAATATATTAAAACAAATTCCCACAGTTCGGTTTGGG
TGACCTCCTCAAAGGCTTCTTCCGTTCCTTCAAATCTCAGTCAGGGTATA
AAATCGTCAAATTCATCATTTGTGTCTCTTAAATCGAGAATCGTCACTAT
TTCTCTCATAAAAGGCGAACGTGGTTTAGGATTCAGTATTGGAGGCGGGC
GTGGAAATGAACACTATGTCGGTGATCCTGGAATATATATTACAAAGGTC
ATGGATAAAGGAGCAGCGGCAACCTGTGGACTGATTTCCGAAGGAGACAA
ATTAGTGCAAGTCAATGATTATTTATTAACCGACGTGACGCACGAGGAAG
CTGTCAAAATATTATGCAATGTTGGTTCCAAGGTCGAATTGAAAATTCTC
AAACCGAATTCTGGAGTTTCGAATAATGTCACGGAACAATTTGAAGAGCC
TTTCAGTAATTGTCAAAGCAGTAAAGATTTATCAGAGTCATTATCTAACA
ATGACAGTCCAGTGAGGCTTAACGGCTCAGACAACAATCATGATATATTT
TTCGATGAAGTTGACAGCAATTTCATAAATAAATCACCGAGAATTGTGGT
TCTGAGTCGGCCGAACGAAACGGTTGGATTCGGTTTCAATATTGTGGGCG
GTGAAGATGAGGATGGAATTTTCGTATCATTTATTATTCCCAGTGGAATC
GCTGACAAAAATGGAAACATCTTTGTTGGAGACAGAATTTGGCAGGTGAA
TGGTACTGATATATCAATTGCTACTCATGATGAAGCCGCTTCTCTTTTAA
AAGGCTCTGGAAAAACTTTAGAGTTATTATTAACTACAGATATGAATGAA
TATGTGGCATTTGAGTCAAAGTTTAACTGGAATACTCACAAAAACAAAGA
CAATAATTGGTCGACGTCAAAATCCACTCCGAATCTTGCTGAAACTATTA
ATAACAAAAATTATTATGAAATGATGCCGAAAAACGACATTCAACATAGA
TCAAACAATGACCACATGCGATCAGTGGGATGTGAGATCAACCATGATCC
CATTTCCATTGATAGACAGCAAATTGAACCTTATCAATCTAGTCCCATGT
ATAAATCTTCTAAGTCAATTGATGTGTTCAATAATGATGGGAAATTATCA
CGTTCCTCTAAAAGAACGAAAACTCCAGCTTCTTGTGATTATGATTCAAG
GATCAGTGAGAAAGAAAATCATCAGATATTCACATTTGAATCGAATACAT
CAACGACCAACAGTGCTACAAATCATTCCGGGATCAGTAATGGATCAGGC
AACCTCACCTCAGACAAGGATAGTGTCACTCGAAAGAATGGATTTTATGT
TCGTGCGTTATTTGAATTTGATCCCGACGTGGAGAAGAATTTGCCTAGTC
GACCTTTAGCCTTTCTTACTAATGATATCATTTTGATAGTGAACTCTGCT
GATCCCGATTGGTGGCAGGCACGCGTAGTTGAAGATAATAATGAAAACGG
CCCACTGGGTATAATTCCAAGTCCAAATAGATTGTATAGAAAAGAAAAAC
GAAACAAGAAAAAGGTAAATTTTGACAGTCAACTCGTTTCGAAAAATTCC
AAGAAAAACAGTTTACCTAGAAACGGAAAACCGTCATTTATTAAGCGAAT
GCAATTGGGTAGTATGAGTAAATCGGCCCAAAATATTACCGAGGATAAAT
CCTACGCCGACGAATACATGAATGAAAAGTTTACTGAAGCAAATCTCATG
CTTTTGTATTATGAGCCTTTAGTGAAAATATCCTTGGATTATGTTCGACC
GGTGGTCATTATTGGCCCGCTTAGGGACAAAATTAATGATACTCTAATTG
ACGAGCACCCGAATCTGTTTGCCAGTTGTGTTCCACATACTACACGCTCG
AAAAAGCCTTTCGAGGTGCATGGTAAAGATTACTATTTCGTTAAAGATCG
AAGTGAAATGGAAGAACAAATCAAACATCAAGAATTCATTGAAGCAGGAC
AATACAAAGACAATCTATATGGAACAAGCATAGCTGCAGTGAGGGATGTT
GCAAAATTGAAACATTGTGTCCTTGATGTGAATGCGTTAGCAATCAAGCG
TCTCGTGGCTGCAAATTTGTTACCTATTACCATTTTGATCAAGCCACCCT
CCGTCAAGGCACTTTGTAACCTCAGCAGTAAAATTACAGTTGCTCAAGCT
GATCGAGAAGTTAAAAAGGCAGAAGAGTTGCAATCCAAAATTAGTCATTA
TTTCACGGCGGTCGTATGGGAAGATAGTTTCAATGGTTTGTATAGTCAAA
TAAAATCCATCGTTCAGTGCAATTCTGGATCCGACATTTGGGTGCCAACC
AACCAAAATACGGTTAACCTCTAACAGTGCAATATTGTTTTTACTTTGTT
ATTTTATCGTAAATTTCCTCATATCACGGTCATTAGATTCTTATGCTTTC
TCTAGCAAACAACTCCGTAG

protein sequence of SMED30019914-orf-1

>SMED30019914-orf-1 ID=SMED30019914-orf-1|Name=SMED30019914-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1105bp
MPVGSSDALKAIELLELYRSKLSETSDKNLIEAIDKVINVFNSQFFIALL
DKSKEGFDLIRKEIQRFYIDILSNNYLSISDKTQETLNFLNSLKLYPSSP
SSVSSSGRVGSRLANDVESINMLYSSLRRKESLTNSNISSHKKYSNTYSQ
PSMSNSNESSSRETNNSFNEIIDQDIDNQLINRPIVMEAVILKGSTGFGF
SVAGGIDNPYFHLNDPGIYVTKITPGGSVDLSGSLNIDDQILSVNGINMT
YLTHEAAVSALKEAGDELHLVIQRDPTLKHRMSGLGYMRRKNASLTASTI
SDSRQDSQAEKSSSQVSPEYIKTNSHSSVWVTSSKASSVPSNLSQGIKSS
NSSFVSLKSRIVTISLIKGERGLGFSIGGGRGNEHYVGDPGIYITKVMDK
GAAATCGLISEGDKLVQVNDYLLTDVTHEEAVKILCNVGSKVELKILKPN
SGVSNNVTEQFEEPFSNCQSSKDLSESLSNNDSPVRLNGSDNNHDIFFDE
VDSNFINKSPRIVVLSRPNETVGFGFNIVGGEDEDGIFVSFIIPSGIADK
NGNIFVGDRIWQVNGTDISIATHDEAASLLKGSGKTLELLLTTDMNEYVA
FESKFNWNTHKNKDNNWSTSKSTPNLAETINNKNYYEMMPKNDIQHRSNN
DHMRSVGCEINHDPISIDRQQIEPYQSSPMYKSSKSIDVFNNDGKLSRSS
KRTKTPASCDYDSRISEKENHQIFTFESNTSTTNSATNHSGISNGSGNLT
SDKDSVTRKNGFYVRALFEFDPDVEKNLPSRPLAFLTNDIILIVNSADPD
WWQARVVEDNNENGPLGIIPSPNRLYRKEKRNKKKVNFDSQLVSKNSKKN
SLPRNGKPSFIKRMQLGSMSKSAQNITEDKSYADEYMNEKFTEANLMLLY
YEPLVKISLDYVRPVVIIGPLRDKINDTLIDEHPNLFASCVPHTTRSKKP
FEVHGKDYYFVKDRSEMEEQIKHQEFIEAGQYKDNLYGTSIAAVRDVAKL
KHCVLDVNALAIKRLVAANLLPITILIKPPSVKALCNLSSKITVAQADRE
VKKAEELQSKISHYFTAVVWEDSFNGLYSQIKSIVQCNSGSDIWVPTNQN
TVNL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0016324	apical plasma membrane
GO:0009898	cytoplasmic side of plasma membrane
GO:0014069	postsynaptic density
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016328	lateral plasma membrane
GO:0030054	cell junction
GO:0031253	cell projection membrane
GO:0031594	neuromuscular junction
GO:0033268	node of Ranvier
GO:0035748	myelin sheath abaxonal region
GO:0042383	sarcolemma
GO:0043219	lateral loop
GO:0045121	membrane raft
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0048471	perinuclear region of cytoplasm
GO:0070062	extracellular exosome
GO:0097025	MPP7-DLG1-LIN7 complex
GO:0001772	immunological synapse
GO:0005605	basal lamina
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005923	bicellular tight junction

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000017	photoreceptor neuron
PLANA:0000099	neuron
PLANA:0000418	head
PLANA:0000461	lateral branch

Vocabulary: **INTERPRO**
Term	Definition
IPR036034	PDZ_sf
IPR036892	L27_dom_sf
IPR036028	SH3-like_dom_sf
IPR001478	PDZ
IPR001452	SH3_domain
IPR008145	GK/Ca_channel_bsu
IPR027417	P-loop_NTPase
IPR015143	L27_1
IPR020590	Guanylate_kinase_CS
IPR008144	Guanylate_kin-like_dom
IPR004172	L27_dom

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0015276	ligand-gated ion channel activity
GO:0015459	potassium channel regulator activity
GO:0019900	kinase binding
GO:0019901	protein kinase binding
GO:0019902	phosphatase binding
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032947	protein complex scaffold
GO:0035255	ionotropic glutamate receptor binding
GO:0044325	ion channel binding
GO:0045296	cadherin binding
GO:0097016	L27 domain binding
GO:0004385	guanylate kinase activity
GO:0004721	phosphoprotein phosphatase activity
GO:0008022	protein C-terminus binding

Vocabulary: **biological process**
Term	Definition
GO:0008104	protein localization
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0016032	viral process
GO:0016337	single organismal cell-cell adhesion
GO:0030432	peristalsis
GO:0030838	positive regulation of actin filament polymerization
GO:0030866	cortical actin cytoskeleton organization
GO:0030953	astral microtubule organization
GO:0031579	membrane raft organization
GO:0031641	regulation of myelination
GO:0032147	activation of protein kinase activity
GO:0034220	ion transmembrane transport
GO:0034629	cellular protein complex localization
GO:0042110	T cell activation
GO:0042130	negative regulation of T cell proliferation
GO:0042391	regulation of membrane potential
GO:0042982	amyloid precursor protein metabolic process
GO:0043113	receptor clustering
GO:0043268	positive regulation of potassium ion transport
GO:0043622	cortical microtubule organization
GO:0045197	establishment or maintenance of epithelial cell apical/basal polarity
GO:0045930	negative regulation of mitotic cell cycle
GO:0046037	GMP metabolic process
GO:0046710	GDP metabolic process
GO:0048608	reproductive structure development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048729	tissue morphogenesis
GO:0048745	smooth muscle tissue development
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051660	establishment of centrosome localization
GO:0051898	negative regulation of protein kinase B signaling
GO:0060022	hard palate development
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:0070830	bicellular tight junction assembly
GO:0072659	protein localization to plasma membrane
GO:0090004	positive regulation of establishment of protein localization to plasma membrane
GO:0097120	receptor localization to synapse
GO:0098911	regulation of ventricular cardiac muscle cell action potential
GO:1902305	regulation of sodium ion transmembrane transport
GO:1903286	regulation of potassium ion import
GO:1903753	negative regulation of p38MAPK cascade
GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
GO:1903764	regulation of potassium ion export across plasma membrane
GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001657	ureteric bud development
GO:0001658	branching involved in ureteric bud morphogenesis
GO:0001771	immunological synapse formation
GO:0001935	endothelial cell proliferation
GO:0002088	lens development in camera-type eye
GO:0002369	T cell cytokine production
GO:0006470	protein dephosphorylation
GO:0007015	actin filament organization
GO:0007093	mitotic cell cycle checkpoint
GO:0007163	establishment or maintenance of cell polarity
GO:0007268	chemical synaptic transmission
GO:0007399	nervous system development

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001452	SH3 domain	SMART	SM00326	SH3_2	coord: 762..831 e-value: 8.6E-4 score: 28.6
IPR001452	SH3 domain	PROSITE	PS50002	SH3	coord: 759..829 score: 14.427
IPR008145	Guanylate kinase/L-type calcium channel beta subunit	SMART	SM00072	gk_7	coord: 911..1089 e-value: 8.0E-55 score: 198.1
IPR008145	Guanylate kinase/L-type calcium channel beta subunit	PFAM	PF00625	Guanylate_kin	coord: 912..1086 e-value: 7.4E-47 score: 159.4
IPR001478	PDZ domain	SMART	SM00228	pdz_new	coord: 196..276 e-value: 2.7E-21 score: 86.7 coord: 522..595 e-value: 1.5E-16 score: 70.9 coord: 371..450 e-value: 1.6E-18 score: 77.5
IPR001478	PDZ domain	PFAM	PF00595	PDZ	coord: 364..447 e-value: 1.3E-16 score: 60.7 coord: 193..273 e-value: 4.6E-19 score: 68.6 coord: 516..591 e-value: 1.4E-16 score: 60.6
IPR001478	PDZ domain	PROSITE	PS50106	PDZ	coord: 512..595 score: 20.506
IPR001478	PDZ domain	PROSITE	PS50106	PDZ	coord: 363..450 score: 20.988
IPR001478	PDZ domain	PROSITE	PS50106	PDZ	coord: 188..276 score: 20.888
None	No IPR available	GENE3D	G3DSA:1.10.287.470		coord: 5..52 e-value: 4.2E-14 score: 54.0
None	No IPR available	GENE3D	G3DSA:2.30.30.40		coord: 753..851 e-value: 1.0E-22 score: 82.1
None	No IPR available	GENE3D	G3DSA:3.40.50.300		coord: 906..1088 e-value: 7.5E-54 score: 184.0
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 838..857
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 730..752
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 839..854
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 138..165
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 296..319
None	No IPR available	PANTHER	PTHR23119:SF5	DISKS LARGE HOMOLOG 1	coord: 191..282
None	No IPR available	PANTHER	PTHR23119	DISCS LARGE	coord: 357..606 coord: 739..1098
None	No IPR available	PANTHER	PTHR23119:SF5	DISKS LARGE HOMOLOG 1	coord: 357..606 coord: 1..54
None	No IPR available	PANTHER	PTHR23119:SF5	DISKS LARGE HOMOLOG 1	coord: 739..1098
None	No IPR available	PANTHER	PTHR23119	DISCS LARGE	coord: 1..54
None	No IPR available	PANTHER	PTHR23119	DISCS LARGE	coord: 191..282
None	No IPR available	CDD	cd00992	PDZ_signaling	coord: 193..273 e-value: 4.4109E-20 score: 83.385
None	No IPR available	CDD	cd00992	PDZ_signaling	coord: 361..447 e-value: 5.77865E-17 score: 74.5254
None	No IPR available	CDD	cd00992	PDZ_signaling	coord: 510..591 e-value: 1.04917E-19 score: 82.6146
IPR036034	PDZ superfamily	GENE3D	G3DSA:2.30.42.10		coord: 158..282 e-value: 3.1E-26 score: 93.6
IPR036034	PDZ superfamily	GENE3D	G3DSA:2.30.42.10		coord: 507..629 e-value: 2.1E-26 score: 94.1
IPR036034	PDZ superfamily	GENE3D	G3DSA:2.30.42.10		coord: 354..451 e-value: 1.4E-25 score: 91.3
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 337..451
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 509..594
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 178..279
IPR015143	L27-1	PFAM	PF09058	L27_1	coord: 2..51 e-value: 1.4E-13 score: 50.5
IPR020590	Guanylate kinase, conserved site	PROSITE	PS00856	GUANYLATE_KINASE_1	coord: 944..961
IPR008144	Guanylate kinase-like domain	PROSITE	PS50052	GUANYLATE_KINASE_2	coord: 912..1086 score: 35.706
IPR027417	P-loop containing nucleoside triphosphate hydrolase	SUPERFAMILY	SSF52540	P-loop containing nucleoside triphosphate hydrolases	coord: 913..1098
IPR036892	L27 domain superfamily	SUPERFAMILY	SSF101288	L27 domain	coord: 6..51
IPR036028	SH3-like domain superfamily	SUPERFAMILY	SSF50044	SH3-domain	coord: 757..936