AP-3 complex subunit sigma

Overview


Name	AP-3 complex subunit sigma
Smed ID	SMED30019823
Length (bp)	1078

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of AP-3 complex subunit sigma (SMED30019823) t-SNE clustered cells

Violin plots show distribution of expression levels for AP-3 complex subunit sigma (SMED30019823) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of AP-3 complex subunit sigma (SMED30019823) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for AP-3 complex subunit sigma (SMED30019823) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019823

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
gut	SMED30019823	h1SMcG0016361	dd_Smed_v4_4819_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30019823	h1SMcG0016361	dd_Smed_v4_4819_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013])

HSP 1 Score: 257.299 bits (656), Expect = 4.326e-85
Identity = 122/172 (70.93%), Postives = 144/172 (83.72%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+ +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPE 172

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BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Match: AP3S2 (adaptor related protein complex 3 subunit sigma 2 [Source:HGNC Symbol;Acc:HGNC:571])

HSP 1 Score: 251.906 bits (642), Expect = 5.072e-83
Identity = 118/170 (69.41%), Postives = 143/170 (84.12%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MI+AILVFNNHGKPR+ +FY  + EE QQ I++ET+ LV KRD+N+CNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINL 170

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BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Match: AP3S2 (adaptor related protein complex 3 subunit sigma 2 [Source:HGNC Symbol;Acc:HGNC:571])

HSP 1 Score: 243.047 bits (619), Expect = 2.332e-79
Identity = 118/184 (64.13%), Postives = 144/184 (78.26%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQ------------VFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MI+AILVFNNHGKPR+ +FY  + EE QQ I++ET+ LV KRD+N+CNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQ            VFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+ +
Sbjct:    1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVHLEVVFFIAPKVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPE 184

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013])

HSP 1 Score: 236.498 bits (602), Expect = 2.307e-77
Identity = 111/160 (69.38%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQ 160

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:HGNC Symbol;Acc:HGNC:2013])

HSP 1 Score: 236.498 bits (602), Expect = 2.307e-77
Identity = 111/160 (69.38%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. Ensembl Celegans
Match: aps-3 (AdaPtin, Small chain (Clathrin associated complex) [Source:UniProtKB/TrEMBL;Acc:Q8T874])

HSP 1 Score: 279.256 bits (713), Expect = 4.306e-94
Identity = 128/180 (71.11%), Postives = 155/180 (86.11%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MIKAILV NNHGKPR+ KFY HY EE+QQ I++ET+ LVSKRD+NVCNFLEGG+LIDG DYRLIYRHYATLYF+FCVD++ESELGILDLIQVFVE+L++CFENVCELD +FH D+V +IL E+VMGG+VLET++ EI+ R  EQ K  +QEAG+ AAP RAVSA+K  N+ Q+ K +KLP
Sbjct:    1 MIKAILVINNHGKPRLLKFYQHYPEEKQQQIVRETFQLVSKRDDNVCNFLEGGTLIDGNDYRLIYRHYATLYFIFCVDSSESELGILDLIQVFVETLDRCFENVCELDLIFHVDRVHHILGEIVMGGMVLETNMNEILQRIQEQDKIQKQEAGITAAPARAVSAVKNMNISQQLKDIKLP 180

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BLAST of AP-3 complex subunit sigma vs. Ensembl Celegans
Match: aps-2 (AP complex subunit sigma [Source:UniProtKB/TrEMBL;Acc:Q19123])

HSP 1 Score: 107.457 bits (267), Expect = 3.887e-28
Identity = 54/138 (39.13%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y H+ ++E+Q +++E +  V+ RD    NF+E       ++++++YR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMHFDDDEKQKLIEEVHACVTVRDAKHTNFVEF------RNFKIVYRRYAGLYFCICVDITDNNLYYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Celegans
Match: aps-1 (AP complex subunit sigma [Source:UniProtKB/TrEMBL;Acc:O16369])

HSP 1 Score: 96.2857 bits (238), Expect = 8.804e-24
Identity = 47/138 (34.06%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            M++ +L+F+  GK R+ K+YT Y +++++ I +E    +  R   +C FLE       +D +++Y+ YA+LYF   ++  ++EL  L++I  +VE L+K F +VCELD +F+ +K  +IL+E ++ G + ETS  +++
Sbjct:    1 MMQYMLLFSRQGKLRLQKWYTAYPDKQKKKICRELITQILARKPKMCAFLEY------KDLKVVYKRYASLYFCCAIEQNDNELITLEVIHRYVELLDKYFGSVCELDIIFNFEKAYFILDEFLLAGEIQETSKKQVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Match: or (gene:FBgn0003008 transcript:FBtr0072152)

HSP 1 Score: 277.33 bits (708), Expect = 2.509e-93
Identity = 129/180 (71.67%), Postives = 157/180 (87.22%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MIKAILVFNNHGKPR++KFY ++ E  QQ I+KET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FHAD V +IL+ELVMGG+VL+T++ +I+ R +EQ K V+QEAG+ AAP RAVSA+K  N+ Q+ K +KLP
Sbjct:    1 MIKAILVFNNHGKPRLSKFYQYFDESLQQQIIKETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHADAVHHILSELVMGGMVLQTNMNDIMARIEEQNKIVKQEAGISAAPARAVSAVKSMNIPQQIKDIKLP 180

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Match: AP-2sigma (gene:FBgn0043012 transcript:FBtr0084103)

HSP 1 Score: 105.145 bits (261), Expect = 3.046e-27
Identity = 53/138 (38.41%), Postives = 89/138 (64.49%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y ++ ++E+Q +++E + +V+ RD    NF+E       ++++++YR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMNFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RNFKIVYRRYAGLYFCICVDVNDNNLCYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYSVVDEMFLAGEIRETSQTKVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Match: AP-1sigma (gene:FBgn0039132 transcript:FBtr0305039)

HSP 1 Score: 97.4413 bits (241), Expect = 3.499e-24
Identity = 54/162 (33.33%), Postives = 97/162 (59.88%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEI--------VLRYDEQVKQVQQEAGL 528
            M+  +L+F+  GK R+ K+Y  Y ++ ++ I +E    +  R   +C+FLE       +D +++Y+ YA+LYF   ++  ++EL  L++I  +VE L+K F +VCELD +F+ +K  +IL+EL++GG + ETS   +        +L+ DE V+   ++ GL
Sbjct:    1 MMLFMLLFSRQGKLRLQKWYMAYPDKVKKKITRELVTTILARKPKMCSFLEW------KDCKIVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLIGGEIQETSKKNVLKAIASQDLLQEDEAVEGTLRDIGL 156

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BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Match: AP-1sigma (gene:FBgn0039132 transcript:FBtr0305040)

HSP 1 Score: 97.4413 bits (241), Expect = 3.499e-24
Identity = 54/162 (33.33%), Postives = 97/162 (59.88%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEI--------VLRYDEQVKQVQQEAGL 528
            M+  +L+F+  GK R+ K+Y  Y ++ ++ I +E    +  R   +C+FLE       +D +++Y+ YA+LYF   ++  ++EL  L++I  +VE L+K F +VCELD +F+ +K  +IL+EL++GG + ETS   +        +L+ DE V+   ++ GL
Sbjct:    1 MMLFMLLFSRQGKLRLQKWYMAYPDKVKKKITRELVTTILARKPKMCSFLEW------KDCKIVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLIGGEIQETSKKNVLKAIASQDLLQEDEAVEGTLRDIGL 156

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Match: AP-1sigma (gene:FBgn0039132 transcript:FBtr0335244)

HSP 1 Score: 95.5153 bits (236), Expect = 1.688e-23
Identity = 52/156 (33.33%), Postives = 93/156 (59.62%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYA 534
            M+  +L+F+  GK R+ K+Y  Y ++ ++ I +E    +  R   +C+FLE       +D +++Y+ YA+LYF   ++  ++EL  L++I  +VE L+K F +VCELD +F+ +K  +IL+EL++GG + ETS   ++     Q    +QE   Y+
Sbjct:    1 MMLFMLLFSRQGKLRLQKWYMAYPDKVKKKITRELVTTILARKPKMCSFLEW------KDCKIVYKRYASLYFCCAIEQNDNELLTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFILDELLIGGEIQETSKKNVLKAIASQDLLQEQEEFFYS 150

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BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Match: ap3s2 (adaptor related protein complex 3 subunit sigma 2 [Source:ZFIN;Acc:ZDB-GENE-040718-274])

HSP 1 Score: 256.914 bits (655), Expect = 4.341e-85
Identity = 119/170 (70.00%), Postives = 146/170 (85.88%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAIL+FNNHGKPR+ +FY +++E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIKAILIFNNHGKPRLIRFYQYFAEDMQQQIIRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQVELQNRMEKSEGGLSAAPARAVSAVKNMNL 170

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Match: ap3s2 (adaptor related protein complex 3 subunit sigma 2 [Source:ZFIN;Acc:ZDB-GENE-040718-274])

HSP 1 Score: 200.675 bits (509), Expect = 1.916e-63
Identity = 100/170 (58.82%), Postives = 124/170 (72.94%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAIL+FNNHGKPR+ +FY +++E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQ                        V YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIKAILIFNNHGKPRLIRFYQYFAEDMQQQIIRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQ------------------------VHYILQEVVMGGMVLETNMNEIVAQVELQNRMEKSEGGLSAAPARAVSAVKNMNL 146

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BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Match: ap2s1 (adaptor related protein complex 2 subunit sigma 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2174])

HSP 1 Score: 108.227 bits (269), Expect = 3.771e-28
Identity = 54/138 (39.13%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y  + ++E+Q +++E + +V+ RD    NF+E       +++++IYR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RNFKIIYRRYAGLYFCICVDVTDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Match: ap1s1 (adaptor related protein complex 1 subunit sigma 1 [Source:ZFIN;Acc:ZDB-GENE-040426-1119])

HSP 1 Score: 105.531 bits (262), Expect = 4.752e-27
Identity = 56/151 (37.09%), Postives = 98/151 (64.90%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQE 519
            M++ +L+F+  GK R+ K+YT  +E +++ +++E   +V  R   +C+FLE       +D +++Y+ YA+LYF   V+  ++EL  L++I  FVE L+K F +VCELD +F+ +K  +IL+E +MGG + +TS  + VL+  EQ   +Q+E
Sbjct:    1 MMRFMLLFSRQGKLRLQKWYTATAERDKKKMVRELMQVVLARKPKMCSFLEW------RDLKIVYKRYASLYFCCAVEEQDNELITLEVIHRFVELLDKYFGSVCELDIIFNFEKAYFILDEFLMGGEIQDTS-KKSVLKAIEQADLLQEE 144

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BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Match: ap1s2 (adaptor related protein complex 1 subunit sigma 2 [Source:ZFIN;Acc:ZDB-GENE-030131-5448])

HSP 1 Score: 103.99 bits (258), Expect = 1.954e-26
Identity = 57/148 (38.51%), Postives = 92/148 (62.16%), Query Frame = 1

Query:   79 ILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEA 522
            +L+F+  GK R+ K+Y   S+ +++ I +E   +V  R   +C+FLE       +D +++Y+ YA+LYF   V+  E+EL  L++I  +VE L+K F +VCELD +F+ +K  YIL+E ++GG   ETS    VL+  EQ   +Q+EA
Sbjct:    4 MLLFSRQGKLRLQKWYVPLSDTQKKKISREVIQMVLARKPKMCSFLEW------RDLKIVYKRYASLYFCCAVEDQENELITLEIIHRYVELLDKYFGSVCELDIIFNFEKAYYILDEFILGGEAQETSKKN-VLKAIEQADMLQEEA 144

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BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Match: kyat1 (kynurenine aminotransferase 1 [Source:Xenbase;Acc:XB-GENE-966486])

HSP 1 Score: 260.766 bits (665), Expect = 1.582e-86
Identity = 123/170 (72.35%), Postives = 143/170 (84.12%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAIL+FNNHGKPR+ KFY HYSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+
Sbjct:    1 MIKAILIFNNHGKPRLCKFYQHYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQTKLEKSEAGLAGAPARAVSAVKNMNL 170

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BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Match: arpin (actin related protein 2/3 complex inhibitor [Source:NCBI gene;Acc:448248])

HSP 1 Score: 259.996 bits (663), Expect = 3.353e-86
Identity = 120/170 (70.59%), Postives = 145/170 (85.29%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAILVFNNHGKPR  +FY H+ E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +F+ DKV YIL+E+VMGG+VLET++ E++ + + Q K  + EAG  AAP RAVSAMK  N+
Sbjct:    1 MIKAILVFNNHGKPRFLRFYQHFPEDTQQQIVRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFNVDKVHYILHEMVMGGMVLETNMSEVITQVEAQSKLEKSEAGFSAAPARAVSAMKNMNL 170

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BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Match: kyat1 (kynurenine aminotransferase 1 [Source:Xenbase;Acc:XB-GENE-966486])

HSP 1 Score: 239.58 bits (610), Expect = 1.087e-78
Identity = 112/160 (70.00%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR+ KFY HYSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLCKFYQHYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQTKLEKSENFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Match: arpin (actin related protein 2/3 complex inhibitor [Source:NCBI gene;Acc:448248])

HSP 1 Score: 223.016 bits (567), Expect = 4.162e-69
Identity = 102/148 (68.92%), Postives = 126/148 (85.14%), Query Frame = 1

Query:  133 YSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            + E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +F+ DKV YIL+E+VMGG+VLET++ E++ + + Q K  + EAG  AAP RAVSAMK  N+
Sbjct:  225 WPEDTQQQIVRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFNVDKVHYILHEMVMGGMVLETNMSEVITQVEAQSKLEKSEAGFSAAPARAVSAMKNMNL 372

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BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Match: ap2s1 (adaptor related protein complex 2 subunit sigma 1 [Source:NCBI gene;Acc:549079])

HSP 1 Score: 108.227 bits (269), Expect = 5.373e-28
Identity = 54/138 (39.13%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y  + ++E+Q +++E + +V+ RD    NF+E       +++++IYR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RNFKIIYRRYAGLYFCICVDVTDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Match: Ap3s1 (adaptor-related protein complex 3, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:1337062])

HSP 1 Score: 257.299 bits (656), Expect = 2.970e-85
Identity = 122/172 (70.93%), Postives = 144/172 (83.72%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+ +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPE 172

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BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Match: Ap3s2 (adaptor-related protein complex 3, sigma 2 subunit [Source:MGI Symbol;Acc:MGI:1337060])

HSP 1 Score: 251.906 bits (642), Expect = 3.482e-83
Identity = 118/170 (69.41%), Postives = 143/170 (84.12%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MI+AILVFNNHGKPR+ +FY  + EE QQ I++ET+ LV KRD+N+CNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINL 170

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Match: Ap3s1 (adaptor-related protein complex 3, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:1337062])

HSP 1 Score: 236.498 bits (602), Expect = 1.584e-77
Identity = 111/160 (69.38%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Match: Ap3s1 (adaptor-related protein complex 3, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:1337062])

HSP 1 Score: 236.498 bits (602), Expect = 1.584e-77
Identity = 111/160 (69.38%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Match: Ap3s1 (adaptor-related protein complex 3, sigma 1 subunit [Source:MGI Symbol;Acc:MGI:1337062])

HSP 1 Score: 236.498 bits (602), Expect = 1.584e-77
Identity = 111/160 (69.38%), Postives = 135/160 (84.38%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSETFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Match: sp|Q9DCR2|AP3S1_MOUSE (AP-3 complex subunit sigma-1 OS=Mus musculus OX=10090 GN=Ap3s1 PE=1 SV=2)

HSP 1 Score: 257.299 bits (656), Expect = 2.077e-84
Identity = 122/172 (70.93%), Postives = 144/172 (83.72%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+ +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPE 172

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BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Match: sp|Q92572|AP3S1_HUMAN (AP-3 complex subunit sigma-1 OS=Homo sapiens OX=9606 GN=AP3S1 PE=1 SV=1)

HSP 1 Score: 257.299 bits (656), Expect = 2.077e-84
Identity = 122/172 (70.93%), Postives = 144/172 (83.72%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+ +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPE 172

[Close]

BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Match: sp|Q2YDH6|AP3S1_BOVIN (AP-3 complex subunit sigma-1 OS=Bos taurus OX=9913 GN=AP3S1 PE=2 SV=1)

HSP 1 Score: 257.299 bits (656), Expect = 2.077e-84
Identity = 122/172 (70.93%), Postives = 144/172 (83.72%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQ 582
            MIKAIL+FNNHGKPR++KFY  YSE+ QQ I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EIV + D Q K  + EAGL  AP RAVSA+K  N+ +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYQPYSEDTQQQIIRETFHLVSKRDENVCNFLEGGLLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEAGLAGAPARAVSAVKNMNLPE 172

[Close]

BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Match: sp|Q1JQA3|AP3S2_BOVIN (AP-3 complex subunit sigma-2 OS=Bos taurus OX=9913 GN=AP3S2 PE=2 SV=1)

HSP 1 Score: 252.292 bits (643), Expect = 2.047e-82
Identity = 118/179 (65.92%), Postives = 147/179 (82.12%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            MI+AILVFNNHGKPR+ +FY  + EE QQ I++ET+ LV KRD+N+CNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+ +  + + +
Sbjct:    1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINLPEMPRNINI 179

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BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Match: sp|Q5RDP9|AP3S2_PONAB (AP-3 complex subunit sigma-2 OS=Pongo abelii OX=9601 GN=AP3S2 PE=2 SV=1)

HSP 1 Score: 251.906 bits (642), Expect = 2.436e-82
Identity = 118/170 (69.41%), Postives = 143/170 (84.12%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MI+AILVFNNHGKPR+ +FY  + EE QQ I++ET+ LV KRD+N+CNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIQAILVFNNHGKPRLVRFYQRFPEEIQQQIVRETFHLVLKRDDNICNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQIEAQNRLEKSEGGLSAAPARAVSAVKNINL 170

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BLAST of AP-3 complex subunit sigma vs. TrEMBL
Match: E0VQM1 (AP-3 complex subunit sigma-2, putative OS=Pediculus humanus subsp. corporis OX=121224 GN=8237205 PE=4 SV=1)

HSP 1 Score: 289.656 bits (740), Expect = 4.232e-94
Identity = 136/187 (72.73%), Postives = 164/187 (87.70%), Query Frame = 1

Query:   46 LIN*LTSMIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            LI+ L  MIKAILVFNNHGKPR+TKFY H++EE QQ I+KET+ LVSKRD+NVCNFLEGG+LI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YILNELVMGG+VLET++ EI++R ++Q K  +QE+G+ AAP RAVSA+K  N+ Q+ K+MKLP
Sbjct:   38 LISNLKKMIKAILVFNNHGKPRLTKFYQHFNEEMQQQIIKETFQLVSKRDDNVCNFLEGGTLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILNELVMGGMVLETNMNEILIRIEDQNKLEKQESGIIAAPARAVSAVKNMNIPQQIKEMKLP 224

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BLAST of AP-3 complex subunit sigma vs. TrEMBL
Match: A0A1I7RLA2 (Clat_adaptor_s domain-containing protein OS=Bursaphelenchus xylophilus OX=6326 PE=4 SV=1)

HSP 1 Score: 286.96 bits (733), Expect = 1.360e-93
Identity = 134/180 (74.44%), Postives = 158/180 (87.78%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MIKAILVFNNHGKPR+ KFYT Y+EEEQQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L++CFENVCELD +FH DKV +ILNELVMGG+VLET++ EI+LR  EQ +  +QEAG+ AAP RAVSAMK  N+ Q+ K +KLP
Sbjct:    1 MIKAILVFNNHGKPRLLKFYTRYTEEEQQHIVRETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDRCFENVCELDLIFHVDKVHHILNELVMGGMVLETNMSEILLRIQEQERLEKQEAGISAAPARAVSAMKNINIPQQIKDLKLP 180

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BLAST of AP-3 complex subunit sigma vs. TrEMBL
Match: Q5DCG1 (AP-3 complex subunit sigma-2 isoform 4 OS=Schistosoma japonicum OX=6182 GN=EWB00_000766 PE=2 SV=1)

HSP 1 Score: 286.574 bits (732), Expect = 1.531e-93
Identity = 131/180 (72.78%), Postives = 158/180 (87.78%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MI+A+LV NNHGKPR+ KFY HYSE+EQQ I+KE + LVS+RD++VCNFLEGG+LI GQDYRLIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FHADKV YILNELV+GG+VLET + EI  RY+EQ K  +QE+GL  AP RAVSAM++ N+ QKFK+++ P
Sbjct:    1 MIRAVLVINNHGKPRLIKFYEHYSEDEQQKIVKEVFNLVSRRDDDVCNFLEGGTLIGGQDYRLIYRHYATLYFVFCVDSSESELGILDLIQVFVEALDKCFENVCELDLIFHADKVHYILNELVLGGMVLETHINEITHRYEEQQKLEKQESGLSGAPARAVSAMRDLNLHQKFKEIRFP 180

[Close]

BLAST of AP-3 complex subunit sigma vs. TrEMBL
Match: A0A4Y2GG66 (AP-3 complex subunit sigma-2 OS=Araneus ventricosus OX=182803 GN=AP3S2_0 PE=4 SV=1)

HSP 1 Score: 286.574 bits (732), Expect = 1.985e-93
Identity = 135/180 (75.00%), Postives = 156/180 (86.67%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MIKAILVFNNHGKPR+TKFY  Y E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YILNELVMGG+VLET++ EI+ R +EQ K  +QEAGL AAP RAVSA+K  N+ Q+ K MKLP
Sbjct:    1 MIKAILVFNNHGKPRLTKFYQFYPEDMQQQIIRETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILNELVMGGMVLETNMSEIITRIEEQNKLEKQEAGLSAAPARAVSAVKNMNIPQQIKDMKLP 180

[Close]

BLAST of AP-3 complex subunit sigma vs. TrEMBL
Match: A0A1Y1K4L4 (Clat_adaptor_s domain-containing protein OS=Photinus pyralis OX=7054 GN=PPYR_02585 PE=4 SV=1)

HSP 1 Score: 286.189 bits (731), Expect = 2.788e-93
Identity = 134/180 (74.44%), Postives = 158/180 (87.78%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLP 606
            MIKAILVFNNHGKPR++KFY ++SE+ QQ I+KET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YILNELVMGG+VLET++ EI+ R D+Q K  +QEAG+ AAP RAVSA+K  N+ Q+ K MKLP
Sbjct:    1 MIKAILVFNNHGKPRLSKFYHYFSEDMQQQIVKETFQLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILNELVMGGMVLETNMTEILTRIDDQNKLEKQEAGITAAPARAVSAVKNMNIPQQIKDMKLP 180

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BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:NCBI gene;Acc:103041421])

HSP 1 Score: 259.61 bits (662), Expect = 2.426e-86
Identity = 120/179 (67.04%), Postives = 148/179 (82.68%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            MIKAIL+FNNHGKPR++KFY HY+E+ +Q I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EI+ + D Q K  + EAG+  AP RAVSA+K  N+ +  K + +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYEHYTEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKSEAGIAGAPARAVSAVKNMNLPEMPKNINI 179

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BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Match: ap3s2 (AP-3 complex subunit sigma-2 [Source:NCBI gene;Acc:103038213])

HSP 1 Score: 256.914 bits (655), Expect = 3.679e-85
Identity = 119/170 (70.00%), Postives = 146/170 (85.88%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAIL+FNNHGKPR+ +FY +++E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+
Sbjct:    1 MIKAILIFNNHGKPRLIRFYQYFAEDMQQQIIRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQVELQNRMEKSEGGLSAAPARAVSAVKNMNL 170

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BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:NCBI gene;Acc:103041421])

HSP 1 Score: 239.195 bits (609), Expect = 1.055e-78
Identity = 109/160 (68.12%), Postives = 136/160 (85.00%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY HY+E+ +Q I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EI+ + D Q K  + E  ++ +P++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYEHYTEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKSETFIFQSPRQ 160

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BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Match: ap3s2 (AP-3 complex subunit sigma-2 [Source:NCBI gene;Acc:103038213])

HSP 1 Score: 217.624 bits (553), Expect = 1.759e-69
Identity = 103/158 (65.19%), Postives = 130/158 (82.28%), Query Frame = 1

Query:  130 HYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            + +E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+ +  + + +
Sbjct:   46 YRAEDMQQQIIRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQVELQNRMEKSEGGLSAAPARAVSAVKNMNLPEIPRNINI 203

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BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:NCBI gene;Acc:103041421])

HSP 1 Score: 203.371 bits (516), Expect = 1.393e-64
Identity = 101/179 (56.42%), Postives = 126/179 (70.39%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            MIKAIL+FNNHGKPR++KFY HY+E+ +Q I++ET+ LVSKRDENVCNFLEGG LI G D +LIYRHYATLYFVFCVD++ESELGILDLIQ                        V  IL E+VMGG+VLET++ EI+ + D Q K  + EAG+  AP RAVSA+K  N+ +  K + +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYEHYTEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDNKLIYRHYATLYFVFCVDSSESELGILDLIQ------------------------VHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKSEAGIAGAPARAVSAVKNMNLPEMPKNINI 155

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BLAST of AP-3 complex subunit sigma vs. Ensembl Sea Lamprey
Match: ap3s2 (adaptor related protein complex 3 subunit sigma 2 [Source:ZFIN;Acc:ZDB-GENE-040718-274])

HSP 1 Score: 231.491 bits (589), Expect = 5.821e-76
Identity = 124/170 (72.94%), Postives = 146/170 (85.88%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNV 576
            MIKAILVFNNHGKPR++KFY  Y E+ QQ I++ET+ LVSKRD+NVCNFLEGG+LI G DY+LIYRHYATLYFVFCVD+ ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YILNE+VMGG+VLET++ EIV + + Q K  + EAGL AAP RAVSA+K  N+
Sbjct:    1 MIKAILVFNNHGKPRLSKFYKFY-EDMQQQIIRETFHLVSKRDDNVCNFLEGGTLIGGSDYKLIYRHYATLYFVFCVDSCESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHYILNEMVMGGMVLETNMNEIVNQIEAQNKLEKSEAGLAAAPARAVSAVKNMNL 169

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BLAST of AP-3 complex subunit sigma vs. Ensembl Sea Lamprey
Match: ap2s1 (adaptor related protein complex 2 subunit sigma 1 [Source:ZFIN;Acc:ZDB-GENE-040426-2174])

HSP 1 Score: 106.686 bits (265), Expect = 1.935e-28
Identity = 53/138 (38.41%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y  + ++E+Q +++E + +V+ RD    NF+E       ++++++YR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RNFKIVYRRYAGLYFCICVDVNDNNLAYLEAIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVL 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Sea Lamprey
Match: copz1 (coatomer protein complex, subunit zeta 1 [Source:ZFIN;Acc:ZDB-GENE-000406-6])

HSP 1 Score: 51.6026 bits (122), Expect = 3.292e-8
Identity = 40/142 (28.17%), Postives = 74/142 (52.11%), Query Frame = 1

Query:   70 IKAILVFNNHGKPRITKFY--THYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCF-ENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLR 486
            +KAI++ +N G+    K+Y  T+ S +EQ++  K  +    + D  +   LEG +++        Y+    LYF       E+EL ++ ++   VESL   F +NV +   + + D V   ++E+V GG+VLE+   +++ R
Sbjct:    8 VKAIIILDNDGERLYAKYYDDTYPSVKEQKTFEKNIFNKTHRTDSEIA-LLEGLTVV--------YKSSVDLYFYVIGSPQENELMLMTVLSCLVESLGHMFRKNVEKRALMENMDAVFLAVDEIVDGGVVLESDPLQVMQR 140

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BLAST of AP-3 complex subunit sigma vs. Ensembl Yeast
Match: APS3 (Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003561])

HSP 1 Score: 122.865 bits (307), Expect = 4.392e-34
Identity = 69/155 (44.52%), Postives = 101/155 (65.16%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENV-CNFL-EGGSLI----------DGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDE 495
            MI A+L+FN   +PR+ KFYT     +Q+ +L++ Y L+S+R+ +   +FL    SL+          + +D ++IY++YATLYF F VD  ESEL ILDLIQ FVESL++CF  V ELD +F+   ++ +L E+V GG+V+ET+V  IV   DE
Sbjct:    1 MIHAVLIFNKKCQPRLVKFYTPVDLPKQKLLLEQVYELISQRNSDFQSSFLVTPPSLLLSNENNNDEVNNEDIQIIYKNYATLYFTFIVDDQESELAILDLIQTFVESLDRCFTEVNELDLIFNWQTLESVLEEIVQGGMVIETNVNRIVASVDE 155

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BLAST of AP-3 complex subunit sigma vs. Ensembl Yeast
Match: APS1 (Small subunit of the clathrin-associated adaptor complex AP-1; AP-1 is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex [Source:SGD;Acc:S000004160])

HSP 1 Score: 87.0409 bits (214), Expect = 3.343e-21
Identity = 49/141 (34.75%), Postives = 84/141 (59.57%), Query Frame = 1

Query:   64 SMIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVF-CVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVM-GGLVLETSVPEIV 480
            + +K +L+ +  GK R+ K+YT  S  E+  I+K+    +  R   +CN +E        D++++Y+ YA+LYF+       ++EL  L++I  FVE+++  F NVCELD +F+  KV  ILNE++M  G + E+S  E++
Sbjct:    2 TQLKYLLLVSRQGKIRLKKWYTAMSAGEKAKIVKDLTPTILARKPKMCNIIEYN------DHKVVYKRYASLYFIVGMTPDVDNELLTLEIIHRFVETMDTYFGNVCELDIIFNFSKVYDILNEMIMCDGSIAESSRKEVL 136

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Yeast
Match: APS2 (Small subunit of the clathrin-associated adaptor complex AP-2; AP-2 is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex [Source:SGD;Acc:S000003819])

HSP 1 Score: 82.4185 bits (202), Expect = 1.490e-19
Identity = 53/135 (39.26%), Postives = 78/135 (57.78%), Query Frame = 1

Query:   70 IKAILVFNNHGKPRITKFYTHYSEEEQQS--ILKETYLLVSKRD-ENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETS 465
            ++ IL FN  G  R+ +++  +S + Q+S   + + Y L+S RD ++  NF+E          +LIYR YA LYFV  VD  + E   L  I +FVE L+  F NVCELD VF+  KV  I++E+ +GG + E S
Sbjct:    3 VQFILCFNKQGVVRLVRWFDVHSSDPQRSQDAIAQIYRLISSRDHKHQSNFVEFSD-----STKLIYRRYAGLYFVMGVDLLDDEPIYLCHIHLFVEVLDAFFGNVCELDIVFNFYKVYMIMDEMFIGGEIQEIS 132

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BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
Match: EDO42407 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1Q2])

HSP 1 Score: 258.455 bits (659), Expect = 3.508e-86
Identity = 117/169 (69.23%), Postives = 147/169 (86.98%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFN 573
            MIK IL+FNNHGKPR+TKFY HYSE+ QQ I+KET+ LVS+RD+NVCNFLEGGSLI G D++L+YRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV +IL E+VMGG+VLET++ EI+   + Q K  + EAG+ AAPQ+A+SA++ ++
Sbjct:    1 MIKGILIFNNHGKPRLTKFYQHYSEDMQQQIIKETFHLVSRRDDNVCNFLEGGSLIGGADFKLVYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHHILAEIVMGGMVLETNMSEILTHIEAQNKLEKSEAGISAAPQKAMSAVRNYS 169

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
Match: EDO38137 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SDU6])

HSP 1 Score: 108.612 bits (270), Expect = 7.747e-29
Identity = 53/133 (39.85%), Postives = 88/133 (66.17%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETS 465
            M+K IL+ N  G  R++++Y +   E++ S+  E       R EN C+F+E       Q+++ +YR YA+LYF+  +D+ E+ELGI++ I  FVE L++ F++VCELD +F+ DKV  +L+E+VM G ++ET+
Sbjct:    1 MLKFILIVNKQGHTRLSQYYEYTKIEDRVSLEAEIIRKCLARSENQCSFIEY------QNFKAVYRRYASLYFIIGIDSTENELGIMEFIHNFVEILDRYFDSVCELDIMFNIDKVHMLLDEMVMNGHIVETN 127

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
Match: EDO42183 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S269])

HSP 1 Score: 108.227 bits (269), Expect = 1.019e-28
Identity = 57/149 (38.26%), Postives = 96/149 (64.43%), Query Frame = 1

Query:   70 IKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQ 516
            I+ IL+ N  GK R+ K+Y ++ ++E+Q +++E + LV+ RD    NF+E       ++++++YR YA LYF FCVD +++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++    +Q+  +QQ
Sbjct:    2 IRFILIQNRAGKTRLAKWYMNFDDDEKQKLIEEVHALVTVRDAKHTNFVEF------RNFKIVYRRYAGLYFCFCVDVSDNNLYYLEAIHNFVEVLNEFFHNVCELDLVFNFYKVYSVVDEMFLAGELRETSQSKVL----KQLNMLQQ 140

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BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
Match: EDO45252 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTE2])

HSP 1 Score: 95.5153 bits (236), Expect = 7.672e-24
Identity = 49/134 (36.57%), Postives = 86/134 (64.18%), Query Frame = 1

Query:   79 ILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            +L+F+  GK R+ K+YT  S++E++ I ++    V  R   +C+FLE       +D ++ Y+ YA+LYF   ++  ++EL  L++I  +VE L+K F +VCELD +F+ +K  ++L+EL++GG V ETS   ++
Sbjct:    3 MLLFSRQGKIRLQKWYTAISQKEKKKITRDLVTTVLSRKPKMCSFLEY------KDMKVCYKRYASLYFCVGIENDDNELLTLEVIHRYVELLDKYFGSVCELDIIFNFEKAYFMLDELLIGGEVQETSKKNVL 130

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BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:NCBI gene;Acc:101158362])

HSP 1 Score: 261.151 bits (666), Expect = 7.282e-87
Identity = 120/179 (67.04%), Postives = 149/179 (83.24%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            MIKAIL+FNNHGKPR++KFY HY+E+ +Q I++ET+ LVSKRDENVCNFLEGG LI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EI+ + D Q K  + EAG+  AP RAVSA+K  N+ +  + + +
Sbjct:    1 MIKAILIFNNHGKPRLSKFYEHYNEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKAEAGIAGAPARAVSAVKNMNLPEMPRNINI 179

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Match: AP3S1 (adaptor related protein complex 3 subunit sigma 1 [Source:NCBI gene;Acc:101158362])

HSP 1 Score: 238.81 bits (608), Expect = 1.289e-78
Identity = 109/160 (68.12%), Postives = 136/160 (85.00%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQR 546
            MIKAIL+FNNHGKPR++KFY HY+E+ +Q I++ET+ LVSKRDENVCNFLEGG LI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV  IL E+VMGG+VLET++ EI+ + D Q K  + E  ++ + ++
Sbjct:    1 MIKAILIFNNHGKPRLSKFYEHYNEDTEQQIIRETFHLVSKRDENVCNFLEGGMLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIITQVDAQNKMEKAETFIFQSTRQ 160

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Match: ap3s2 (adaptor related protein complex 3 subunit sigma 2 [Source:NCBI gene;Acc:101163313])

HSP 1 Score: 218.394 bits (555), Expect = 1.689e-70
Identity = 103/156 (66.03%), Postives = 129/156 (82.69%), Query Frame = 1

Query:  136 SEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            +E+ QQ I++ET+ LVSKRD+NVCNFLEGGSLI G DY+LIYRHYATLYFVFCVD++ESELGILDLIQVFVE+L+KCFENVCELD +FH DKV YIL E+VMGG+VLET++ EIV + + Q +  + E GL AAP RAVSA+K  N+ +  + + +
Sbjct:    1 TEDMQQQIIRETFHLVSKRDDNVCNFLEGGSLIGGSDYKLIYRHYATLYFVFCVDSSESELGILDLIQVFVETLDKCFENVCELDLIFHMDKVHYILQEVVMGGMVLETNMNEIVAQVEVQNRMEKSEGGLSAAPARAVSAVKNMNLPEIPRNINI 156

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Match: ap2s1 (adaptor related protein complex 2 subunit sigma 1 [Source:NCBI gene;Acc:101160086])

HSP 1 Score: 106.686 bits (265), Expect = 8.999e-28
Identity = 54/138 (39.13%), Postives = 88/138 (63.77%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y  + ++E+Q +++E + +V+ RD    NF+E       +++++IYR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMQFDDDEKQKLIEEVHAVVTVRDAKHTNFVEF------RNFKIIYRRYAGLYFCICVDVTDNNLAYLEGIHNFVEVLNEYFHNVCELDLVFNFYKVYTVVDEMFLAGEIRETSQTKVL 132

[Close]

BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Match: ap1s3b (AP-1 complex subunit sigma-3 [Source:NCBI gene;Acc:101171526])

HSP 1 Score: 107.071 bits (266), Expect = 1.096e-27
Identity = 53/132 (40.15%), Postives = 86/132 (65.15%), Query Frame = 1

Query:   70 IKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETS 465
            ++ +L+F+  GK R+ K++T  +E E++ I+++   LV  R    CNFL+       +D ++IY+ YA+LYF   V+  E+EL  L++I  +VE L+K F NVCELD +F+ +K  +IL+E +MGG + ETS
Sbjct:    3 MRFLLLFSRQGKLRLQKWFTPITEREKKKIIRDMTTLVLARQPRSCNFLQW------KDLKIIYKRYASLYFCLAVENQENELLALEVIHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFLMGGEIQETS 128

[Close]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Match: SMESG000048773.1 (SMESG000048773.1)

HSP 1 Score: 429.098 bits (1102), Expect = 1.003e-152
Identity = 220/220 (100.00%), Postives = 220/220 (100.00%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLPHGXXXXXXXXXXXXLPNSLASKFSNSATNSIVDSSIRDEI 726
            MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLPHGVASSVAVMASSVLPNSLASKFSNSATNSIVDSSIRDEI
Sbjct:    1 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKLPHGVASSVAVMASSVLPNSLASKFSNSATNSIVDSSIRDEI 220

[Close]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Match: SMESG000011941.1 (SMESG000011941.1)

HSP 1 Score: 243.432 bits (620), Expect = 4.917e-80
Identity = 115/179 (64.25%), Postives = 146/179 (81.56%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQEAGLYAAPQRAVSAMKEFNVGQKFKQMKL 603
            MI+AIL+FNNHGKPR+ KFY +Y EE QQ I+KE + LVSKR ++VCNFLE GSL++G+D +L+YRHYATLYFVFCVD++ESELGILDLIQVFVESL+K FENVCELD +F+ DKV +IL ELV+GGLVLET + EI+ RYD+Q K  ++E G+      AVSA+K  N+ Q+ + +KL
Sbjct:    1 MIQAILIFNNHGKPRLIKFYEYYPEEMQQKIVKEIFQLVSKRSDDVCNFLESGSLMNGKDNKLVYRHYATLYFVFCVDSSESELGILDLIQVFVESLDKAFENVCELDLIFNIDKVHHILKELVVGGLVLETHMSEILSRYDDQNKLEREENGISIKSGSAVSAVKSINIPQRIRDIKL 179

[Close]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Match: SMESG000038894.1 (SMESG000038894.1)

HSP 1 Score: 107.071 bits (266), Expect = 4.814e-28
Identity = 55/138 (39.86%), Postives = 87/138 (63.04%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            M++ IL+ N  GK R+ K+Y  + +EE+Q +++E + LV+ RD    NF+E  +      ++++YR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  KV  +++E+ + G + ETS  +I+
Sbjct:    1 MLRFILIQNRAGKTRLAKWYMTFDDEEKQKLIEEVHALVTVRDAKHTNFVEFRT------FKIVYRRYAGLYFCICVDVMDNSLMYLEAIHNFVEVLNEMFHNVCELDLVFNFYKVYSVVDEMFLAGEIRETSQTKIL 132

[Close]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Match: SMESG000038889.1 (SMESG000038889.1)

HSP 1 Score: 107.071 bits (266), Expect = 5.929e-28
Identity = 54/138 (39.13%), Postives = 87/138 (63.04%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIV 480
            MI+ IL+ N  GK R+ K+Y  + +EE+Q +++E + LV+ RD    NF+E  +      ++++YR YA LYF  CVD  ++ L  L+ I  FVE LN+ F NVCELD VF+  +V  +++E+ + G + ETS  +++
Sbjct:    1 MIRFILIQNRAGKTRLAKWYMTFDDEEKQKLIEEVHALVTVRDAKHTNFVEFRT------FKIVYRRYAGLYFCICVDVMDNSLMYLEAIHNFVEVLNELFHNVCELDLVFNFYRVYSVVDEMFLAGEIRETSQTKVL 132

[Close]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Match: SMESG000063235.1 (SMESG000063235.1)

HSP 1 Score: 100.908 bits (250), Expect = 1.944e-25
Identity = 54/151 (35.76%), Postives = 94/151 (62.25%), Query Frame = 1

Query:   67 MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFLEGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKCFENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQE 519
            M++ +L+F+  GK R+ K+Y  +S++ ++ IL+E   LV  R   +C F+E       +D +++YR YA+LYF   V+  ++EL  L++I  +VE L+K F +VCELD +F+ +K  ++L+E ++ G V ETS   ++   D Q   +Q+E
Sbjct:    1 MMQFMLLFSRQGKVRLQKWYVAHSDKTRKKILRELTSLVLTRKPKMCAFIEW------KDLKIVYRRYASLYFCCAVEREDNELVTLEIIHRYVELLDKYFGSVCELDIIFNFEKAYFMLDEFMLAGEVQETSKKNVLKAVDAQ-DMIQEE 144

The following BLAST results are available for this feature:

BLAST of AP-3 complex subunit sigma vs. Ensembl Human
BLAST of AP-3 complex subunit sigma vs. Ensembl Celegans
BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
BLAST of AP-3 complex subunit sigma vs. TrEMBL
BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
BLAST of AP-3 complex subunit sigma vs. Ensembl Sea Lamprey
BLAST of AP-3 complex subunit sigma vs. Ensembl Yeast
BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
BLAST of AP-3 complex subunit sigma vs. Planmine SMEST

BLAST of AP-3 complex subunit sigma vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
AP3S1	4.326e-85	70.93	adaptor related protein complex 3 subunit sigma 1 ...	[more]
AP3S2	5.072e-83	69.41	adaptor related protein complex 3 subunit sigma 2 ...	[more]
AP3S2	2.332e-79	64.13	adaptor related protein complex 3 subunit sigma 2 ...	[more]
AP3S1	2.307e-77	69.38	adaptor related protein complex 3 subunit sigma 1 ...	[more]
AP3S1	2.307e-77	69.38	adaptor related protein complex 3 subunit sigma 1 ...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 3


Match Name	E-value	Identity	Description
aps-3	4.306e-94	71.11	AdaPtin, Small chain (Clathrin associated complex)...	[more]
aps-2	3.887e-28	39.13	AP complex subunit sigma [Source:UniProtKB/TrEMBL...	[more]
aps-1	8.804e-24	34.06	AP complex subunit sigma [Source:UniProtKB/TrEMBL...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
or	2.509e-93	71.67	gene:FBgn0003008 transcript:FBtr0072152	[more]
AP-2sigma	3.046e-27	38.41	gene:FBgn0043012 transcript:FBtr0084103	[more]
AP-1sigma	3.499e-24	33.33	gene:FBgn0039132 transcript:FBtr0305039	[more]
AP-1sigma	3.499e-24	33.33	gene:FBgn0039132 transcript:FBtr0305040	[more]
AP-1sigma	1.688e-23	33.33	gene:FBgn0039132 transcript:FBtr0335244	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ap3s2	4.341e-85	70.00	adaptor related protein complex 3 subunit sigma 2 ...	[more]
ap3s2	1.916e-63	58.82	adaptor related protein complex 3 subunit sigma 2 ...	[more]
ap2s1	3.771e-28	39.13	adaptor related protein complex 2 subunit sigma 1 ...	[more]
ap1s1	4.752e-27	37.09	adaptor related protein complex 1 subunit sigma 1 ...	[more]
ap1s2	1.954e-26	38.51	adaptor related protein complex 1 subunit sigma 2 ...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
kyat1	1.582e-86	72.35	kynurenine aminotransferase 1 [Source:Xenbase;Acc:...	[more]
arpin	3.353e-86	70.59	actin related protein 2/3 complex inhibitor [Sourc...	[more]
kyat1	1.087e-78	70.00	kynurenine aminotransferase 1 [Source:Xenbase;Acc:...	[more]
arpin	4.162e-69	68.92	actin related protein 2/3 complex inhibitor [Sourc...	[more]
ap2s1	5.373e-28	39.13	adaptor related protein complex 2 subunit sigma 1 ...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Ap3s1	2.970e-85	70.93	adaptor-related protein complex 3, sigma 1 subunit...	[more]
Ap3s2	3.482e-83	69.41	adaptor-related protein complex 3, sigma 2 subunit...	[more]
Ap3s1	1.584e-77	69.38	adaptor-related protein complex 3, sigma 1 subunit...	[more]
Ap3s1	1.584e-77	69.38	adaptor-related protein complex 3, sigma 1 subunit...	[more]
Ap3s1	1.584e-77	69.38	adaptor-related protein complex 3, sigma 1 subunit...	[more]

BLAST of AP-3 complex subunit sigma vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9DCR2\|AP3S1_MOUSE	2.077e-84	70.93	AP-3 complex subunit sigma-1 OS=Mus musculus OX=10...	[more]
sp\|Q92572\|AP3S1_HUMAN	2.077e-84	70.93	AP-3 complex subunit sigma-1 OS=Homo sapiens OX=96...	[more]
sp\|Q2YDH6\|AP3S1_BOVIN	2.077e-84	70.93	AP-3 complex subunit sigma-1 OS=Bos taurus OX=9913...	[more]
sp\|Q1JQA3\|AP3S2_BOVIN	2.047e-82	65.92	AP-3 complex subunit sigma-2 OS=Bos taurus OX=9913...	[more]
sp\|Q5RDP9\|AP3S2_PONAB	2.436e-82	69.41	AP-3 complex subunit sigma-2 OS=Pongo abelii OX=96...	[more]

BLAST of AP-3 complex subunit sigma vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
E0VQM1	4.232e-94	72.73	AP-3 complex subunit sigma-2, putative OS=Pediculu...	[more]
A0A1I7RLA2	1.360e-93	74.44	Clat_adaptor_s domain-containing protein OS=Bursap...	[more]
Q5DCG1	1.531e-93	72.78	AP-3 complex subunit sigma-2 isoform 4 OS=Schistos...	[more]
A0A4Y2GG66	1.985e-93	75.00	AP-3 complex subunit sigma-2 OS=Araneus ventricosu...	[more]
A0A1Y1K4L4	2.788e-93	74.44	Clat_adaptor_s domain-containing protein OS=Photin...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
AP3S1	2.426e-86	67.04	adaptor related protein complex 3 subunit sigma 1 ...	[more]
ap3s2	3.679e-85	70.00	AP-3 complex subunit sigma-2 [Source:NCBI gene;Acc...	[more]
AP3S1	1.055e-78	68.13	adaptor related protein complex 3 subunit sigma 1 ...	[more]
ap3s2	1.759e-69	65.19	AP-3 complex subunit sigma-2 [Source:NCBI gene;Acc...	[more]
AP3S1	1.393e-64	56.42	adaptor related protein complex 3 subunit sigma 1 ...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3


Match Name	E-value	Identity	Description
ap3s2	5.821e-76	72.94	adaptor related protein complex 3 subunit sigma 2 ...	[more]
ap2s1	1.935e-28	38.41	adaptor related protein complex 2 subunit sigma 1 ...	[more]
copz1	3.292e-8	28.17	coatomer protein complex, subunit zeta 1 [Source:Z...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 3


Match Name	E-value	Identity	Description
APS3	4.392e-34	44.52	Small subunit of the clathrin-associated adaptor c...	[more]
APS1	3.343e-21	34.75	Small subunit of the clathrin-associated adaptor c...	[more]
APS2	1.490e-19	39.26	Small subunit of the clathrin-associated adaptor c...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 4


Match Name	E-value	Identity	Description
EDO42407	3.508e-86	69.23	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38137	7.747e-29	39.85	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42183	1.019e-28	38.26	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO45252	7.672e-24	36.57	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of AP-3 complex subunit sigma vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
AP3S1	7.282e-87	67.04	adaptor related protein complex 3 subunit sigma 1 ...	[more]
AP3S1	1.289e-78	68.13	adaptor related protein complex 3 subunit sigma 1 ...	[more]
ap3s2	1.689e-70	66.03	adaptor related protein complex 3 subunit sigma 2 ...	[more]
ap2s1	8.999e-28	39.13	adaptor related protein complex 2 subunit sigma 1 ...	[more]
ap1s3b	1.096e-27	40.15	AP-1 complex subunit sigma-3 [Source:NCBI gene;Acc...	[more]

BLAST of AP-3 complex subunit sigma vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000048773.1	1.003e-152	100.00	SMESG000048773.1	[more]
SMESG000011941.1	4.917e-80	64.25	SMESG000011941.1	[more]
SMESG000038894.1	4.814e-28	39.86	SMESG000038894.1	[more]
SMESG000038889.1	5.929e-28	39.13	SMESG000038889.1	[more]
SMESG000063235.1	1.944e-25	35.76	SMESG000063235.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019823 ID=SMED30019823|Name=AP-3 complex subunit sigma|organism=Schmidtea mediterranea sexual|type=transcript|length=1078bp
TCTAAACGGTTTACTTGATACTTGGATAATAAAATAAACTTGTATTTAAT
TAATTGATTAACTTCAATGATAAAAGCTATTCTAGTATTTAATAACCATG
GGAAACCGAGGATAACCAAGTTCTACACTCACTATTCAGAGGAAGAACAG
CAATCTATTTTAAAAGAAACTTATTTATTAGTTTCAAAAAGAGATGAAAA
TGTATGTAACTTTTTGGAAGGTGGGAGTCTCATTGATGGTCAAGACTATC
GCTTAATTTATAGGCATTACGCAACACTTTATTTTGTGTTTTGTGTTGAT
ACGGCAGAAAGTGAATTGGGAATTTTAGATTTAATTCAGGTTTTTGTGGA
ATCACTTAATAAATGTTTTGAAAACGTTTGCGAATTAGATTTTGTCTTTC
ACGCTGATAAAGTCCAATATATTCTAAATGAGCTGGTAATGGGGGGATTG
GTCCTGGAAACCTCTGTCCCAGAGATTGTGCTTAGGTATGATGAGCAAGT
GAAGCAAGTCCAACAGGAAGCCGGGTTGTATGCAGCTCCACAGCGAGCTG
TATCGGCAATGAAGGAATTTAATGTCGGACAGAAATTCAAACAAATGAAA
TTACCTCATGGTGTTGCGTCATCTGTCGCGGTAATGGCATCTTCCGTGCT
TCCGAATTCTTTAGCATCGAAATTCTCAAATTCAGCAACCAATTCAATTG
TCGACTCATCAATCAGAGATGAGATTTAGTCATTCCTGCCTCGTTTTACT
GATCTCTCTTTTCGGCATTTTATTTGTGTGTTTTGTTGTTGTGTTATCAT
TATTTTCTTATAAATATCGTGAGCGTTTGGTGCTGCTAATCGTAAATCCC
TTTATATCTCTCTCGTTTCGACTCGTATTGAATTAAGTGAGCAGCTTGCG
TCGATTCAAAATAATCACAATTCTAGCTGAAAATACCTTTTAAAAATTTT
AATTTTGCGGGGGGTTAAAAAATAATTTTGTTAATTTAATTTTTTGTTTA
AATGAAGTTATTTAAATATTTTATTAATTTTTTTAAAAATATGTTTTAGA
CTTATTCAGCGGGTAACTTTTGCTAGAT

protein sequence of SMED30019823-orf-1

>SMED30019823-orf-1 ID=SMED30019823-orf-1|Name=SMED30019823-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=221bp
MIKAILVFNNHGKPRITKFYTHYSEEEQQSILKETYLLVSKRDENVCNFL
EGGSLIDGQDYRLIYRHYATLYFVFCVDTAESELGILDLIQVFVESLNKC
FENVCELDFVFHADKVQYILNELVMGGLVLETSVPEIVLRYDEQVKQVQQ
EAGLYAAPQRAVSAMKEFNVGQKFKQMKLPHGVASSVAVMASSVLPNSLA
SKFSNSATNSIVDSSIRDEI*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000026	gut

Vocabulary: **INTERPRO**
Term	Definition
IPR016635	AP_complex_ssu
IPR022775	AP_mu_sigma_su
IPR000804	Clathrin_sm-chain_CS
IPR011012	Longin-like_dom_sf

Vocabulary: **biological process**
Term	Definition
GO:0016192	vesicle-mediated transport
GO:0006886	intracellular protein transport
GO:0006810	transport
GO:0015031	protein transport

Vocabulary: **cellular component**
Term	Definition
GO:0030117	membrane coat
GO:0016020	membrane
GO:0016021	integral component of membrane

Vocabulary: **molecular function**
Term	Definition
GO:0008565	protein transporter activity

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	GENE3D	G3DSA:3.30.450.60		coord: 1..157 e-value: 6.3E-59 score: 200.1
None	No IPR available	PANTHER	PTHR11753:SF10	AP-3 COMPLEX SUBUNIT SIGMA-2	coord: 1..177
None	No IPR available	CDD	cd14834	AP3_sigma	coord: 1..146 e-value: 2.2418E-102 score: 290.668
IPR022775	AP complex, mu/sigma subunit	PFAM	PF01217	Clat_adaptor_s	coord: 1..142 e-value: 1.2E-48 score: 164.7
IPR016635	Adaptor protein complex, sigma subunit	PANTHER	PTHR11753	CLATHRIN COAT ASSEMBLY PROTEIN	coord: 1..177
IPR000804	Clathrin adaptor complex, small chain	PROSITE	PS00989	CLAT_ADAPTOR_S	coord: 63..73
IPR011012	Longin-like domain superfamily	SUPERFAMILY	SSF64356	SNARE-like	coord: 1..138