Cyclin-dependent kinase 12
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019786 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 3
Homology
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 239.965 bits (611), Expect = 1.222e-63 Identity = 139/391 (35.55%), Postives = 211/391 (53.96%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E A P + P K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 675 PG-GDLSPPDSPEPKAITPPQQPYK--KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1041
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 239.58 bits (610), Expect = 3.774e-63 Identity = 139/391 (35.55%), Postives = 211/391 (53.96%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E A P + P K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 676 PG-GDLSPPDSPEPKAITPPQQPYK--KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1042
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK12 (cyclin dependent kinase 12 [Source:HGNC Symbol;Acc:HGNC:24224]) HSP 1 Score: 239.58 bits (610), Expect = 3.831e-63 Identity = 139/391 (35.55%), Postives = 211/391 (53.96%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E A P + P K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 676 PG-GDLSPPDSPEPKAITPPQQPYK--KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1042
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK13 (cyclin dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733]) HSP 1 Score: 216.853 bits (551), Expect = 6.599e-61 Identity = 123/352 (34.94%), Postives = 195/352 (55.40%), Query Frame = 2
Query: 2747 TPITVTKKPKLCSNRH---KIKSMNESKSLYN-FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
T + ++PK+C R+ K K ++ K + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H ++I +IV ++ ++ K +FY VFEY++HDL GLL+S + F+ + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y RK+ E IP A D+ + D SKR TA+ AL +L D+E
Sbjct: 58 TQLHSKRRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK---QYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVE 388
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Match: CDK13 (cyclin dependent kinase 13 [Source:HGNC Symbol;Acc:HGNC:1733]) HSP 1 Score: 230.72 bits (587), Expect = 1.854e-60 Identity = 133/398 (33.42%), Postives = 215/398 (54.02%), Query Frame = 2
Query: 2765 KKPKLCSNRH---KIKSMNESKSLYN-FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQ 3943
++PK+C R+ K K ++ K + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H ++I +IV ++ ++ K +FY VFEY++HDL GLL+S + F+ + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y RK+ E IP A D+ + D SKR TA+ AL +L D+E M P + P +DCHE + + Q + + D+++ + AP+
Sbjct: 678 RRPKICGPRYGETKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK---KQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHE----------LWSKKRRRQKQMGMTDDVSTIKAPR 1044
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 230.335 bits (586), Expect = 5.080e-63 Identity = 131/370 (35.41%), Postives = 210/370 (56.76%), Query Frame = 2
Query: 2759 VTKKPKLCSNR-HKIKSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+ +P + + R H ++S S Y NL IG G++G++++AV+ + +VALKR+ L N +G P +REI + + L+H N+++ +DIV+++I + K + +FY VFEYV+HDL GLL+S ++ F+ QI L KQL LAYIH+ +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YG +D+WS GC++ E+ T ++ L + + F LE ++K+ GSPN WP++T+ ++ + Y R+I EE+ +P +A D+L ++ + KRI+AK AL W+ +E + P + P +DCHE
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTR------ANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVIT-----LWYRPPELLLGDERYGPAIDVWSTGCMLGELFT--------RKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFR---MKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEM 627
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 230.335 bits (586), Expect = 5.561e-63 Identity = 131/370 (35.41%), Postives = 210/370 (56.76%), Query Frame = 2
Query: 2759 VTKKPKLCSNR-HKIKSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+ +P + + R H ++S S Y NL IG G++G++++AV+ + +VALKR+ L N +G P +REI + + L+H N+++ +DIV+++I + K + +FY VFEYV+HDL GLL+S ++ F+ QI L KQL LAYIH+ +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YG +D+WS GC++ E+ T ++ L + + F LE ++K+ GSPN WP++T+ ++ + Y R+I EE+ +P +A D+L ++ + KRI+AK AL W+ +E + P + P +DCHE
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTR------ANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVIT-----LWYRPPELLLGDERYGPAIDVWSTGCMLGELFT--------RKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFR---MKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEM 627
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-12 (Cyclin-dependent kinase 12 [Source:UniProtKB/Swiss-Prot;Acc:P46551]) HSP 1 Score: 229.95 bits (585), Expect = 6.712e-63 Identity = 131/370 (35.41%), Postives = 210/370 (56.76%), Query Frame = 2
Query: 2759 VTKKPKLCSNR-HKIKSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+ +P + + R H ++S S Y NL IG G++G++++AV+ + +VALKR+ L N +G P +REI + + L+H N+++ +DIV+++I + K + +FY VFEYV+HDL GLL+S ++ F+ QI L KQL LAYIH+ +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YG +D+WS GC++ E+ T ++ L + + F LE ++K+ GSPN WP++T+ ++ + Y R+I EE+ +P +A D+L ++ + KRI+AK AL W+ +E + P + P +DCHE
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTR------ANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVIT-----LWYRPPELLLGDERYGPAIDVWSTGCMLGELFT--------RKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFR---MKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEM 627
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-2 (Cyclin-dependent kinase 2 [Source:UniProtKB/Swiss-Prot;Acc:O61847]) HSP 1 Score: 164.081 bits (414), Expect = 4.936e-44 Identity = 103/320 (32.19%), Postives = 167/320 (52.19%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLK----SNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLV 3781
F +R IG G++G +F+A+ N++ ALK I ++GIP LREI K L H N++ DI+ ++N Y VFE+++ DL LL+ +NS++ F+ QL SAL+Y H + I+HRD+ P N++VS G++K+ADFG AR + + T + V YR PEIL+ + Y T +D+WS GC+ EI + L+ E L + +I+G+PN WP V ++ + + +N +K+EE + + DVL++I ++ +R+TAKGAL+ + +
Sbjct: 15 FCSLRRIGEGTYGVVFKAIHVRDNVKCALKMIRTDRDEEGIPSTCLREISCIKDLQHDNIVTLFDII----------YAN------SKLYMVFEFIDRDLKNLLEMLEPTNSVLPPNYVKSFMW-QLLSALSYCHLRRIVHRDLKPQNILVSDSGVIKIADFGLARNFSFPSR-----NYTHEVVTLWYRPPEILLGSQRYSTSLDMWSLGCIFSEIASNKPLFP--------GECEISQLFKIFEIVGTPNIKSWPGVDSFPHYKAVFPQW-PVNL-KKLEE-TSCLTGNGLDVLREILRYPPERRLTAKGALSHRYFL 301
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Match: cdk-11.2 (Cyclin-Dependent Kinase family [Source:UniProtKB/TrEMBL;Acc:Q23357]) HSP 1 Score: 166.777 bits (421), Expect = 2.153e-42 Identity = 98/333 (29.43%), Postives = 171/333 (51.35%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREI-LLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGL---LKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP 3820
+ ++ VI G++G++F + ++ VALKR + +G P LREI +L K+ H N++ +I+V S K++ Y EYVEHD+ L ++S + F Q L QL S + ++H I+HRD+ SNL++S GILK+ADFG AR + ++ + LTP V YR+PE+L+E + Y T VD+WS GC++ E + ++ +S + + +++G+P +WPD+ + K ++ + + R+I + K + D+L + + + R+TA AL +W + +A+ P + P
Sbjct: 304 YVILNVIAEGTYGEVFRGKNTRTDEVVALKRFKMEKEKEGFPITALREINMLLKAGAHENIVNVKEILVG---STKTEV-----------YMAMEYVEHDVKSLIDKMRSRNQRFKTGQQKTLMSQLLSGIEHMHKLWILHRDLKTSNLLISHSGILKIADFGLAREYGEARDIEKRMKLTPIVVTLWYRSPELLLEPKTYSTPVDMWSIGCIMAEFIMMKPMFQ--------GDSEPNQVHQIFQMMGTPTEQIWPDIKELKVWNMVEFPPVKPGQLRRIFKGEKLVNETGFDLLNGMLCLNPANRLTASEALQHDWFSE-HPKAVPPEDLP 613
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0078357) HSP 1 Score: 215.698 bits (548), Expect = 1.833e-56 Identity = 123/337 (36.50%), Postives = 184/337 (54.60%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
F +I IG G++G++++A D +N VALK++ L + +G P +REI + + LNH N++ +IV ++ +++ + SFY VFEY++HDL GLL+S + F+ + KQL L Y H KN +HRDI SN++++ G +KLADFG ARL D D T K + YR PE+L+ E YG +D+WS GC++ E+ L+ E LE ++KI GSP P+VWP+V K F L + + R++ E + +P A D+L ++ D KRITA+ AL S WL I M + P +DCHE
Sbjct: 804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDK------GSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNAD---DRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE--------MAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKT---HRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHEL 1120
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0332716) HSP 1 Score: 215.698 bits (548), Expect = 1.833e-56 Identity = 123/337 (36.50%), Postives = 184/337 (54.60%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
F +I IG G++G++++A D +N VALK++ L + +G P +REI + + LNH N++ +IV ++ +++ + SFY VFEY++HDL GLL+S + F+ + KQL L Y H KN +HRDI SN++++ G +KLADFG ARL D D T K + YR PE+L+ E YG +D+WS GC++ E+ L+ E LE ++KI GSP P+VWP+V K F L + + R++ E + +P A D+L ++ D KRITA+ AL S WL I M + P +DCHE
Sbjct: 804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDK------GSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNAD---DRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE--------MAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKT---HRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHEL 1120
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk12 (gene:FBgn0037093 transcript:FBtr0078358) HSP 1 Score: 215.698 bits (548), Expect = 1.833e-56 Identity = 123/337 (36.50%), Postives = 184/337 (54.60%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
F +I IG G++G++++A D +N VALK++ L + +G P +REI + + LNH N++ +IV ++ +++ + SFY VFEY++HDL GLL+S + F+ + KQL L Y H KN +HRDI SN++++ G +KLADFG ARL D D T K + YR PE+L+ E YG +D+WS GC++ E+ L+ E LE ++KI GSP P+VWP+V K F L + + R++ E + +P A D+L ++ D KRITA+ AL S WL I M + P +DCHE
Sbjct: 804 FEMIAQIGEGTYGQVYKARDHHTNDMVALKKVRLEHEKEGFPITAVREIKILRQLNHRNIVNLHEIVTDKQDAVEFRKDK------GSFYLVFEYMDHDLMGLLESGMVDFNEENNASIMKQLLDGLNYCHKKNFLHRDIKCSNILMNNRGKVKLADFGLARLYNAD---DRERPYTNKVITLWYRPPELLLGEERYGPSIDVWSCGCILGELFVKRPLFQANAE--------MAQLETISKICGSPVPAVWPNVIKLPLFHTLKQKKT---HRRRLREDFEFMPAPALDLLDKMLDLDPDKRITAEDALRSPWLRKINPDEMPTPQLPTWQDCHEL 1120
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk9 (gene:FBgn0019949 transcript:FBtr0071937) HSP 1 Score: 169.474 bits (428), Expect = 3.705e-45 Identity = 97/281 (34.52%), Postives = 157/281 (55.87%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLR-VALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPY 3691
IG G+FG++F+A +K N + VA+K++ + N +G P LREI + + L H NV+ ++I + + S +FY VF++ EHDL GLL + ++ FS+ +I + +QL + L YIH I+HRD+ +N++++K GILKLADFG AR + N T + V YR PE+L+ NYG VD+W AGC++ E+ T S I + N + F ++++ GS P VWP V + + + + + N R+++E ++ PY
Sbjct: 56 IGQGTFGEVFKAREKKGNKKFVAMKKVLMDNEKEGFPITALREIRILQLLKHENVVNLIEICRTKATATNGYRS--------TFYLVFDFCEHDLAGLLSNMNVKFSLGEIKKVMQQLLNGLYYIHSNKILHRDMKAANVLITKHGILKLADFGLARAFSIPKNESKN-RYTNRVVTLWYRPPELLLGDRNYGPPVDMWGAGCIMAEMWTRS---PIMQGNTEQQQLTF-----ISQLCGSFTPDVWPGVEELELYKSI---ELPKNQKRRVKERLR--PY 314
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Match: Cdk2 (gene:FBgn0004107 transcript:FBtr0083922) HSP 1 Score: 157.147 bits (396), Expect = 8.626e-42 Identity = 100/322 (31.06%), Postives = 159/322 (49.38%), Query Frame = 2
Query: 2825 LYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
L NF IG G++G +++A + VALK+I L +G+P +REI L K+L H NV+Q D+V++ + Y +FEY+ DL L+ +F+ I Q+ A+ + H I+HRD+ P NL+V G +KLADFG AR ++ A T + V YRAPEIL+ + Y T VDIWS GC+ E+ I + +L +S + L + + L +P+ + WP VT+ F R N + I E ++A +++ + +D + RI+AK AL + +++
Sbjct: 5 LDNFQRAEKIGEGTYGIVYKARSNSTGQDVALKKIRLEGETEGVPSTAIREISLLKNLKHPNVVQLFDVVISG----------------NNLYMIFEYLNMDLKKLMDKKKDVFTPQLIKSYMHQILDAVGFCHTNRILHRDLKPQNLLVDTAGKIKLADFGLARAFNVPMR-----AYTHEVVTLWYRAPEILLGTKFYSTGVDIWSLGCIFSEM--------IMRRSLFPGDSEIDQLYRIFRTLSTPDETNWPGVTQLPDFKTKFPRWEGTNMPQPITE------HEAHELIMSMLCYDPNLRISAKDALQHAYFRNVQ 291
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk12 (cyclin-dependent kinase 12 [Source:ZFIN;Acc:ZDB-GENE-081104-294]) HSP 1 Score: 240.736 bits (613), Expect = 6.856e-64 Identity = 131/387 (33.85%), Postives = 211/387 (54.52%), Query Frame = 2
Query: 2696 GKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
G PP+ + P P + K+PK+CS R+ + ++ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS + +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E L LE ++++ GSP P+ WPDV + YF+ + + Y R++ E +P A D+L + D S+R TA+ AL S +L D+E M P + P +DCHE
Sbjct: 626 GDPSPPQSPARVSPPLLQP-SFKKRPKICSPRYGERKQTQTDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVSFSHEHVQSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELL--------QLELISRLCGSPCPAAWPDVIRLPYFNTMRPKK---QYRRRLREEFSFLPTPALDLLDHMLTLDPSRRCTAEQALASQFLCDVEPNKMPPPDLPHWQDCHEL 990
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk13 (cyclin-dependent kinase 13 [Source:ZFIN;Acc:ZDB-GENE-030131-4975]) HSP 1 Score: 228.024 bits (580), Expect = 6.493e-60 Identity = 131/371 (35.31%), Postives = 205/371 (55.26%), Query Frame = 2
Query: 2744 RTPITVTKKPKLCSNR-HKIKSMN---ESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+TP ++PK+C R +IK + + F +I + G G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ ++ F N + +FY VFEY++HDL GLL+S + F+ S I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y R++ E IP A D+ + D SKR TA+ AL S++L D++ M P + P +DCHE
Sbjct: 561 KTPAP-RRRPKICGPRFGEIKETEIDWGKRCVDKFEIIGITGEGTYGQVYKAKDKDTAELVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALD--FKNDKG----AFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFAFIPLMALDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHEL 909
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 172.17 bits (435), Expect = 5.137e-47 Identity = 102/323 (31.58%), Postives = 165/323 (51.08%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRK-IEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEM 3793
+F + IG G++G +++A +K + VALK+I L +G+P +REI L K LNH N+++ D++ E Y VFE++ DL + S S+ S+ + QL LA+ H ++HRD+ P NL+++ G +KLADFG AR V+ T + V YRAPEIL+ + Y T VDIWS GC+ E++T + L +S + L + + LG+P+ S+WP VT + + ++R+ + + + + D D+L Q+ +D +KRI+AK AL + D+ M
Sbjct: 3 SFQKVEKIGEGTYGVVYKAKNKVTGETVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLRDVIHTE----------------NKLYLVFEFLHQDLKRFMDSTSVSGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVR-----TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIT--------RRALFPGDSEIDQLFRIFRTLGTPDESIWPGVTSMPDYKPSFPK-----WARQDLSKVVPPLDEDGRDLLGQMLTYDPNKRISAKNALVHRFFRDVTM 291
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 168.703 bits (426), Expect = 8.954e-45 Identity = 99/313 (31.63%), Postives = 174/313 (55.59%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARL--LTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSK--YFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWL 3778
IG G+FG++F+A + + +VALK++ + N +G P LREI + + L H NV+ ++I + ++F+ + S Y VF++ EHDL GLL + ++ F++++I + + L + L YIH I+HRD+ +N+++++ G+LKLADFG AR L K+ Q + T + V YR PE+L+ +YG +D+W AGC++ E +WT + + + L ++++ GS P VWP V K Y + +G +++ Y+K PY A D++ ++ D ++RI + AL ++
Sbjct: 46 IGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKA----TQFNRYKG----SIYLVFDFCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNR---YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE------MWT--RSPIMQGNTEQHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKD-PY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 337
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 168.703 bits (426), Expect = 8.954e-45 Identity = 99/313 (31.63%), Postives = 174/313 (55.59%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARL--LTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSK--YFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWL 3778
IG G+FG++F+A + + +VALK++ + N +G P LREI + + L H NV+ ++I + ++F+ + S Y VF++ EHDL GLL + ++ F++++I + + L + L YIH I+HRD+ +N+++++ G+LKLADFG AR L K+ Q + T + V YR PE+L+ +YG +D+W AGC++ E +WT + + + L ++++ GS P VWP V K Y + +G +++ Y+K PY A D++ ++ D ++RI + AL ++
Sbjct: 46 IGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKA----TQFNRYKG----SIYLVFDFCEHDLAGLLSNANVKFTLAEIKRVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFSLAKNSQGNR---YTNRVVTLWYRPPELLLGERDYGPPIDLWGAGCIMAE------MWT--RSPIMQGNTEQHQLTLISQLCGSITPEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKD-PY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 337
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 236.498 bits (602), Expect = 2.071e-63 Identity = 134/391 (34.27%), Postives = 212/391 (54.22%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++ M + P +DCHE
Sbjct: 383 PG-GDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 749
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 223.787 bits (569), Expect = 4.630e-63 Identity = 126/373 (33.78%), Postives = 202/373 (54.16%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEM 3793
PG S P P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++
Sbjct: 47 PGGDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDV 396
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 236.498 bits (602), Expect = 1.853e-62 Identity = 134/391 (34.27%), Postives = 212/391 (54.22%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++ M + P +DCHE
Sbjct: 659 PG-GDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 1025
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 236.113 bits (601), Expect = 1.992e-62 Identity = 134/391 (34.27%), Postives = 212/391 (54.22%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++ M + P +DCHE
Sbjct: 659 PG-GDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 1025
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:100038049]) HSP 1 Score: 235.343 bits (599), Expect = 2.249e-62 Identity = 134/391 (34.27%), Postives = 212/391 (54.22%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++ M + P +DCHE
Sbjct: 659 PG-GDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 1025
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 238.81 bits (608), Expect = 2.178e-63 Identity = 130/364 (35.71%), Postives = 201/364 (55.22%), Query Frame = 2
Query: 2765 KKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1038
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 238.424 bits (607), Expect = 5.559e-63 Identity = 130/364 (35.71%), Postives = 201/364 (55.22%), Query Frame = 2
Query: 2765 KKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1038
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk12 (cyclin-dependent kinase 12 [Source:MGI Symbol;Acc:MGI:1098802]) HSP 1 Score: 238.424 bits (607), Expect = 5.619e-63 Identity = 130/364 (35.71%), Postives = 201/364 (55.22%), Query Frame = 2
Query: 2765 KKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1038
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk13 (cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]) HSP 1 Score: 230.335 bits (586), Expect = 4.594e-62 Identity = 133/398 (33.42%), Postives = 215/398 (54.02%), Query Frame = 2
Query: 2765 KKPKLCSNRH---KIKSMNESKSLYN-FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQ 3943
++PK+C R+ K K ++ K + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H ++I +IV ++ ++ K +FY VFEY++HDL GLL+S + F+ + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y RK+ E IP A D+ + D SKR TA+ AL +L D+E M P + P +DCHE + + Q + + D+++ + AP+
Sbjct: 64 RRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPKK---QYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHE----------LWSKKRRRQKQMGMTDDLSTIKAPR 430
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Match: Cdk13 (cyclin-dependent kinase 13 [Source:MGI Symbol;Acc:MGI:1916812]) HSP 1 Score: 231.106 bits (588), Expect = 9.481e-61 Identity = 133/398 (33.42%), Postives = 215/398 (54.02%), Query Frame = 2
Query: 2765 KKPKLCSNRH---KIKSMNESKSLYN-FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQ 3943
++PK+C R+ K K ++ K + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H ++I +IV ++ ++ K +FY VFEY++HDL GLL+S + F+ + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y RK+ E IP A D+ + D SKR TA+ AL +L D+E M P + P +DCHE + + Q + + D+++ + AP+
Sbjct: 678 RRPKICGPRYGEIKEKDIDWGKRCVDKFDIIGIIGEGTYGQVYKARDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLTHQSIINMKEIVTDKEDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFNENHIKSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK---KQYRRKLREEFVFIPAAALDLFDYMLALDPSKRCTAEQALQCEFLRDVEPSKMPPPDLPLWQDCHE----------LWSKKRRRQKQMGMTDDLSTIKAPR 1044
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q9NYV4|CDK12_HUMAN (Cyclin-dependent kinase 12 OS=Homo sapiens OX=9606 GN=CDK12 PE=1 SV=2) HSP 1 Score: 239.58 bits (610), Expect = 1.840e-62 Identity = 139/391 (35.55%), Postives = 211/391 (53.96%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E A P + P K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 676 PG-GDLSPPDSPEPKAITPPQQPYK--KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1042
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q3MJK5|CDK12_RAT (Cyclin-dependent kinase 12 OS=Rattus norvegicus OX=10116 GN=Cdk12 PE=1 SV=1) HSP 1 Score: 238.424 bits (607), Expect = 3.447e-62 Identity = 130/364 (35.71%), Postives = 201/364 (55.22%), Query Frame = 2
Query: 2765 KKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1038
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|Q14AX6|CDK12_MOUSE (Cyclin-dependent kinase 12 OS=Mus musculus OX=10090 GN=Cdk12 PE=1 SV=2) HSP 1 Score: 238.424 bits (607), Expect = 3.889e-62 Identity = 130/364 (35.71%), Postives = 201/364 (55.22%), Query Frame = 2
Query: 2765 KKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
K+PK+C R+ + ES + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E IP A D+L + D SKR TA+ L S++L D+E+ M P + P +DCHE
Sbjct: 696 KRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHEL 1038
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|P46551|CDK12_CAEEL (Cyclin-dependent kinase 12 OS=Caenorhabditis elegans OX=6239 GN=cdk-12 PE=1 SV=4) HSP 1 Score: 230.335 bits (586), Expect = 6.462e-62 Identity = 131/370 (35.41%), Postives = 210/370 (56.76%), Query Frame = 2
Query: 2759 VTKKPKLCSNR-HKIKSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+ +P + + R H ++S S Y NL IG G++G++++AV+ + +VALKR+ L N +G P +REI + + L+H N+++ +DIV+++I + K + +FY VFEYV+HDL GLL+S ++ F+ QI L KQL LAYIH+ +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YG +D+WS GC++ E+ T ++ L + + F LE ++K+ GSPN WP++T+ ++ + Y R+I EE+ +P +A D+L ++ + KRI+AK AL W+ +E + P + P +DCHE
Sbjct: 280 IATRPVITTRRGHATNRPSDSDSWYKTNLTHYTMLDQIGEGTYGQVYKAVNNLTGEQVALKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDISMDELKRTR------ANFYLVFEYVDHDLIGLLESKELVDFNKDQICSLFKQLLEGLAYIHNTGFLHRDIKCSNILVNNKGELKIADLGLARLWEKESRLYTNRVIT-----LWYRPPELLLGDERYGPAIDVWSTGCMLGELFT--------RKPLFNGNNEFGQLELISKVCGSPNVDNWPELTELVGWNTFR---MKRTYQRRIREEFEHIMPREAVDLLDKMLTLNPEKRISAKEALNHPWIRSLEHTTVQPLKLPQHQDCHEM 627
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Match: sp|B5DE93|CDK12_XENTR (Cyclin-dependent kinase 12 OS=Xenopus tropicalis OX=8364 GN=cdk12 PE=2 SV=1) HSP 1 Score: 235.728 bits (600), Expect = 1.311e-61 Identity = 134/391 (34.27%), Postives = 212/391 (54.22%), Query Frame = 2
Query: 2687 PGKGKSRPPRYIEISA-CPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
PG G PP E P + P+ K+PK+C R+ + E+ + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L + D SKR TA+ L S++L D+++ M + P +DCHE
Sbjct: 659 PG-GDPSPPDSPERKVVAPPQPPLK--KRPKICCPRYGERKQTETDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHKSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSEDHIKSFMKQLMEGLEYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKK---QYRRRLREEFSFVPTPALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVDVCKMATPDLPHWQDCHEL 1025
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A2G5UE33 (Protein kinase domain-containing protein OS=Caenorhabditis nigoni OX=1611254 GN=Cni-cdk-12 PE=4 SV=1) HSP 1 Score: 244.588 bits (623), Expect = 2.871e-65 Identity = 137/372 (36.83%), Postives = 218/372 (58.60%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKI-KSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIM--SIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+T +P + + R + K+ ++S S Y NL IG G++G++++A+++ + +VA+KR+ L N +G P +REI + + L+H N+++ +DIV+++I +K +N FY VFEYV+HDL GLL+S ++ FS QI L KQL LAYIH +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YGT VD+WSAGC++ E+ T ++ L + F L+ ++K+ GSP+P WP++T+ +++ R +Y RKI EEY +P DA D+L ++ + +RI+AK AL W+ ++E + P + P +DCHE
Sbjct: 159 ITSRPVIITKRGVVFKTPSDSDSWYKTNLTHYEMLDQIGEGTYGQVYKAINRLTGEQVAMKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDITLNQLKETRAN--------FYLVFEYVDHDLIGLLESKELVDFSKEQICSLFKQLLEGLAYIHATGFLHRDIKCSNILVNNKGELKIADLGLARLWQKESRLYTNNVIT-----LWYRPPELLLGDERYGTAVDVWSAGCMLGELFT--------RKPLFNGSDPFGQLDLISKVCGSPSPESWPELTELTFWNTFKQRR---SYPRKIREEYEHLMPRDAVDLLDKMLTLNPERRISAKDALLHPWIRNLEHACVQPLKLPQHQDCHEM 506
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A2G5UF16 (Protein kinase domain-containing protein OS=Caenorhabditis nigoni OX=1611254 GN=Cni-cdk-12 PE=4 SV=1) HSP 1 Score: 244.973 bits (624), Expect = 3.951e-65 Identity = 137/372 (36.83%), Postives = 218/372 (58.60%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKI-KSMNESKSLYNFNLIRV-----IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIM--SIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+T +P + + R + K+ ++S S Y NL IG G++G++++A+++ + +VA+KR+ L N +G P +REI + + L+H N+++ +DIV+++I +K +N FY VFEYV+HDL GLL+S ++ FS QI L KQL LAYIH +HRDI SN++V+ G LK+AD G ARL K+ +L N +T YR PE+L+ E YGT VD+WSAGC++ E+ T ++ L + F L+ ++K+ GSP+P WP++T+ +++ R +Y RKI EEY +P DA D+L ++ + +RI+AK AL W+ ++E + P + P +DCHE
Sbjct: 188 ITSRPVIITKRGVVFKTPSDSDSWYKTNLTHYEMLDQIGEGTYGQVYKAINRLTGEQVAMKRVRLENEKEGFPITAIREIKILRQLHHKNIVRLMDIVIDDITLNQLKETRAN--------FYLVFEYVDHDLIGLLESKELVDFSKEQICSLFKQLLEGLAYIHATGFLHRDIKCSNILVNNKGELKIADLGLARLWQKESRLYTNNVIT-----LWYRPPELLLGDERYGTAVDVWSAGCMLGELFT--------RKPLFNGSDPFGQLDLISKVCGSPSPESWPELTELTFWNTFKQRR---SYPRKIREEYEHLMPRDAVDLLDKMLTLNPERRISAKDALLHPWIRNLEHACVQPLKLPQHQDCHEM 535
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: G4VF20 (Protein kinase OS=Schistosoma mansoni OX=6183 GN=Smp_007510 PE=4 SV=1) HSP 1 Score: 243.432 bits (620), Expect = 5.874e-64 Identity = 127/364 (34.89%), Postives = 205/364 (56.32%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKIKSMNE--SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+TK+PK+C+ R K ++ +S+ F+ + +G G++G +++A DK + ALK++ L N +G P +REI + + L H N++ +IV ++ K +F+ VF+Y++HDL+G+L+S + FS I L KQL L++ HD++ +HRDI SN++++ G LKLADFG ARL + D T K + YR PE+L+ E YG VDIWS GC++ E+ T ++ +E E LE +++I G P+P++WP+V K ++S + + + Y R++ E IP A D+L + Q D KR +A+ AL S WL +I+ + P P D+DCHE
Sbjct: 173 ITKRPKICALRSKSRNNKTWGERSVTAFDTLIQVGEGTYGHVYKARDKITGEYKALKKVRLENEREGFPITAVREIKILRQLRHPNIVNLCEIVTDKDDPTDFKKDK------GAFFLVFDYMDHDLYGILESGLVTFSEQHIASLMKQLLDGLSFCHDRHFLHRDIKCSNILINNKGQLKLADFGLARLY---IAGDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGEMFTRRPMFQASEE--------VEQLEVISRICGYPDPAIWPNVEKLPFYSTIKPKKM---YRRRLREEYHIIPPHAVDLLDHMLQLDPQKRCSAREALASPWLRNIDPTKISPPRLPVDQDCHEM 516
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A183QQ38 (Protein kinase domain-containing protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1) HSP 1 Score: 243.432 bits (620), Expect = 5.929e-64 Identity = 127/364 (34.89%), Postives = 205/364 (56.32%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKIKSMNE--SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+TK+PK+C+ R K ++ +S+ F+ + +G G++G +++A DK + ALK++ L N +G P +REI + + L H N++ +IV ++ K +F+ VF+Y++HDL+G+L+S + FS I L KQL L++ HD++ +HRDI SN++++ G LKLADFG ARL + D T K + YR PE+L+ E YG VDIWS GC++ E+ T ++ +E E LE +++I G P+P++WP+V K ++S + + + Y R++ E IP A D+L + Q D KR +A+ AL S WL +I+ + P P D+DCHE
Sbjct: 173 ITKRPKICALRSKSRNNKTWGERSVTAFDTLIQVGEGTYGHVYKARDKITGEYKALKKVRLENEREGFPITAVREIKILRQLRHPNIVNLCEIVTDKDDPTDFKKDK------GAFFLVFDYMDHDLYGILESGLVAFSEQHIASLMKQLLDGLSFCHDRHFLHRDIKCSNILINNKGQLKLADFGLARLY---IAGDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGEMFTRRPMFQASEE--------VEQLEVISRICGYPDPAIWPNVEKLPFYSTIKPKKM---YRRRLREEYHIIPPHAVDLLDHMLQLDPQKRCSAREALASPWLRNIDPTKISPPRLPVDQDCHEM 516
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Match: A0A183PGK4 (Protein kinase domain-containing protein OS=Schistosoma mattheei OX=31246 GN=SMTD_LOCUS13490 PE=4 SV=1) HSP 1 Score: 243.432 bits (620), Expect = 7.082e-64 Identity = 127/364 (34.89%), Postives = 205/364 (56.32%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKIKSMNE--SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+TK+PK+C+ R K ++ +S+ F+ + +G G++G +++A DK + ALK++ L N +G P +REI + + L H N++ +IV ++ K +F+ VF+Y++HDL+G+L+S + FS I L KQL L++ HD++ +HRDI SN++++ G LKLADFG ARL + D T K + YR PE+L+ E YG VDIWS GC++ E+ T ++ +E E LE +++I G P+P++WP+V K ++S + + + Y R++ E IP A D+L + Q D KR +A+ AL S WL +I+ + P P D+DCHE
Sbjct: 172 ITKRPKICALRSKSRNNKTWGERSVTAFDTLIQVGEGTYGHVYKARDKITGEYKALKKVRLENEREGFPITAVREIKILRQLRHPNIVNLCEIVTDKDDPTDFKKDK------GAFFLVFDYMDHDLYGILESGLVAFSEQHIASLMKQLLDGLSFCHDRHFLHRDIKCSNILINNKGQLKLADFGLARLY---IAGDKERPYTNKVITLWYRPPELLLGEERYGPAVDIWSCGCILGEMFTRRPMFQASEE--------VEQLEVISRICGYPDPAIWPNVEKLPFYSTIKPKKM---YRRRLREEYHIIPPHAVDLLDHMLQLDPQKRCSAREALASPWLRNIDPTKISPPRLPVDQDCHEM 515
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk12 (cyclin dependent kinase 12 [Source:NCBI gene;Acc:103040863]) HSP 1 Score: 241.506 bits (615), Expect = 2.766e-64 Identity = 129/367 (35.15%), Postives = 203/367 (55.31%), Query Frame = 2
Query: 2756 TVTKKPKLCSNRHKIKSMNE----SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
T K+PK CS R + + + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E L LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L ++ D S+R TA+ AL S +L D++ M P + P +DCHE
Sbjct: 655 TYKKRPKFCSPRFGERRQTQIDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVSFSQEHIRSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELL--------QLELISRLCGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFSFLPTPALDLLDRMLTLDPSRRCTAEQALESQFLCDVDPSKMSPPDLPHWQDCHEL 1000
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk12 (cyclin dependent kinase 12 [Source:NCBI gene;Acc:103040863]) HSP 1 Score: 241.506 bits (615), Expect = 2.789e-64 Identity = 129/367 (35.15%), Postives = 203/367 (55.31%), Query Frame = 2
Query: 2756 TVTKKPKLCSNRHKIKSMNE----SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
T K+PK CS R + + + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E L LE ++++ GSP P+VWPDV K YF+ + + Y R++ E +P A D+L ++ D S+R TA+ AL S +L D++ M P + P +DCHE
Sbjct: 644 TYKKRPKFCSPRFGERRQTQIDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVSFSQEHIRSFMRQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELL--------QLELISRLCGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFSFLPTPALDLLDRMLTLDPSRRCTAEQALESQFLCDVDPSKMSPPDLPHWQDCHEL 989
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk13 (cyclin dependent kinase 13 [Source:NCBI gene;Acc:103043281]) HSP 1 Score: 230.72 bits (587), Expect = 1.015e-60 Identity = 131/371 (35.31%), Postives = 207/371 (55.80%), Query Frame = 2
Query: 2744 RTPITVTKKPKLCSNR-HKIKSMN---ESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
+TP T+ ++PK+C R +IK + + F ++ + G G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ ++ F N + +FY VFEY++HDL GLL+S + F+ S I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K YF+ + + Y R++ E IP A D+ + D SKR TA+ AL S++L D++ M P + P +DCHE
Sbjct: 606 KTP-TLRRRPKICGPRFGEIKETEIDWGKRCVDKFEILGITGEGTYGQVYKARDKDTAEMVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALD--FKNDKG----AFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPYFNTMKPK---KQYRRRLREEFAFIPPTALDLFDHMLALDPSKRCTAEQALNSDFLRDVDPAKMPPPDLPLWQDCHEL 954
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk2 (cyclin dependent kinase 2 [Source:NCBI gene;Acc:103028318]) HSP 1 Score: 172.555 bits (436), Expect = 2.765e-47 Identity = 102/325 (31.38%), Postives = 165/325 (50.77%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIP---YDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEM 3793
+F + IG G++G +++A +K + VALK+I L +G+P +REI L K L+H N+++ +D++ E Y VFE++ DL + S+S+ S+ + QL LA+ H ++HRD+ P NL+++ G +KLADFG AR V+ T + V YRAPEIL+ + Y T VDIWS GC+ E++T + L +S + L + + LG+P+ +VWP VT + + +++ K +P D D+L Q+ +D +KRI+AK AL + D+ M
Sbjct: 6 SFQKVEKIGEGTYGVVYKAKNKITGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVKLLDVIHTE----------------NKLYLVFEFLHQDLKKFMDSSSVTGISLPLVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVR-----TYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMIT--------RRALFPGDSEIDQLFRIFRTLGTPDETVWPGVTSMPDYKPSFPKW-------ALQDLAKVVPPLDEDGRDLLGQMLNYDPNKRISAKNALVHRFFRDVTM 294
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Match: cdk9 (cyclin-dependent kinase 9 (CDC2-related kinase) [Source:ZFIN;Acc:ZDB-GENE-030131-321]) HSP 1 Score: 165.236 bits (417), Expect = 4.666e-43 Identity = 98/313 (31.31%), Postives = 172/313 (54.95%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARL--LTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSK--YFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWL 3778
IG G+FG++F+A + + +VALK++ + N +G P LREI + + L H NV+ ++I + ++F+ + S Y VF++ EHDL GLL + ++ F++++I + + L + L YIH I+HRD+ +N+++++ GILKLADFG AR L K+ Q + T + V YR PE+L+ +YG +D+W GC++ E +WT + + + L ++++ GS VWP V K Y + +G +++ Y+K PY A D++ ++ D ++RI + AL ++
Sbjct: 110 IGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENVVNLIEICRTK----ATQFNRYKG----SIYLVFDFCEHDLAGLLSNANVKFTLAEIKKVMQMLLNGLYYIHRNKILHRDMKAANVLITRDGILKLADFGLARAFSLAKNSQGNR---YTNRVVTLWYRPPELLLGERDYGPPIDLWGGGCIMAE------MWT--RSPIMQGNTEQHQLTLISQLCGSITAEVWPGVDKKYELYQKMELPKGQKRKVKDRLKAYVKD-PY-ALDLIDKLLVLDPAQRIDSDDALNHDFF 401
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000855.1 (pep scaffold:Pmarinus_7.0:GL480767:13986:34488:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000855.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 231.876 bits (590), Expect = 3.039e-62 Identity = 133/374 (35.56%), Postives = 207/374 (55.35%), Query Frame = 2
Query: 2744 RTPITVT---KKPKLCSNRH-KIKSMNE---SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
RTP T ++PK+C R+ +IK + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ +I K +FY VF+Y++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E YG +D+WS GC++ E+ T ++ +E LE ++++ G+P P+VWPDV K YF + + Y R++ E +P A D+ + D SKR TA+ AL S++L DI+ M P + P +DCHE
Sbjct: 561 RTPPVQTPTRRRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDK------GAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQE--------MAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPKK---QYRRRLREEFSMLPTAALDLFDHLA-LDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHEL 912
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000851.1 (pep scaffold:Pmarinus_7.0:GL480767:12807:33146:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000851.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 231.876 bits (590), Expect = 5.896e-62 Identity = 133/374 (35.56%), Postives = 207/374 (55.35%), Query Frame = 2
Query: 2744 RTPITVT---KKPKLCSNRH-KIKSMNE---SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
RTP T ++PK+C R+ +IK + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ +I K +FY VF+Y++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E YG +D+WS GC++ E+ T ++ +E LE ++++ G+P P+VWPDV K YF + + Y R++ E +P A D+ + D SKR TA+ AL S++L DI+ M P + P +DCHE
Sbjct: 519 RTPPVQTPTRRRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDK------GAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQE--------MAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPK---KQYRRRLREEFSMLPTAALDLF-DMLALDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHEL 870
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000850.1 (pep scaffold:Pmarinus_7.0:GL480767:12801:33146:-1 gene:ENSPMAG00000000768.1 transcript:ENSPMAT00000000850.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 231.876 bits (590), Expect = 6.613e-62 Identity = 133/374 (35.56%), Postives = 207/374 (55.35%), Query Frame = 2
Query: 2744 RTPITVT---KKPKLCSNRH-KIKSMNE---SKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
RTP T ++PK+C R+ +IK + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ +I K +FY VF+Y++HDL GLL+S + FS I KQL L Y H KN +HRDI SN++++ G +KLADFG ARL + + + T K + YR PE+L+ E YG +D+WS GC++ E+ T ++ +E LE ++++ G+P P+VWPDV K YF + + Y R++ E +P A D+ + D SKR TA+ AL S++L DI+ M P + P +DCHE
Sbjct: 518 RTPPVQTPTRRRPKICGPRYGEIKGTEADWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLNHRSIINMKEIVTDKEDAIDFKKDK------GAFYLVFDYMDHDLMGLLESGLVSFSEDHIKSFMKQLMEGLDYCHRKNFLHRDIKCSNILLNNRGHIKLADFGLARLYSS----EESRPYTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTRKPIFQANQE--------MAQLELISRLCGTPCPAVWPDVIKLPYFHTMKPKK---QYRRRLREEFSMLPTAALDLF-DMLALDPSKRCTAEQALQSDFLRDIDPYKMPPPDLPLWQDCHEL 869
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 167.162 bits (422), Expect = 4.774e-46 Identity = 98/323 (30.34%), Postives = 167/323 (51.70%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLL-KSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIP-YDAA--DVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
F + IG G++G +++A K + VALK+I L +G+P +REI L + LNH N+++ +D++ +E Y VFE+++ DL + + + S+ + QL +A+ H + +HRD+ P NL+++ G +KLADFG AR ++ T + V YRAPEIL+ + Y T VD+WS GC+ E+LT + L +S + L + + LG+P+ +VW +T+ + R A ++ K +P DAA D+L Q+ Q+D ++R++AK AL ++ ++E
Sbjct: 4 FQKVEKIGEGTYGVVYKARHKMTGDTVALKKIRLDTETEGVPSTAIREIALLRELNHPNIVRLLDVIHSE----------------TKLYLVFEFLDQDLKKYMDNAPPLGISLPLVKSYMHQLLQGIAFCHAQRTLHRDLKPQNLLINADGAIKLADFGLARAFGVPLR-----TYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMLT--------RRALFPGDSEIDQLFRIFRTLGTPDETVWQGITQLPDYKPSFPRWCA-------QDLTKVVPLLDAAGHDLLMQMLQYDPTRRVSAKAALNHHFFHNLE 290
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Match: cdk2 (cyclin-dependent kinase 2 [Source:ZFIN;Acc:ZDB-GENE-040426-2741]) HSP 1 Score: 163.696 bits (413), Expect = 7.549e-45 Identity = 94/321 (29.28%), Postives = 165/321 (51.40%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLL-KSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
NF + IG G++G +++A +K + VALK+I L +G+P +REI L + LNH N+++ + I+ +E K Y VFE ++ DL + + + + QL +A+ H I+HRD+ P NL+++ G +KLADFG AR + T + V YRAPEIL+ ++Y T VD+WS GC+ E+LT + L +S + L + + LG+P+ VWP V++ + R ++++ + + T+ ++ D+L + Q+D ++R+TA AL+ + +++
Sbjct: 3 NFQKVEKIGEGTYGVVYKARNKLTGEAVALKKIRLDTETEGVPSTAIREISLLRELNHPNIVRLLTIIHSE----------------KKLYLVFELLDQDLKKFMDNATPSGIPLPLVKSYLYQLLQGIAFCHSHRILHRDLKPQNLLINAEGAIKLADFGLARAFGVPQR-----TYTHEVVTLWYRAPEILLGCKHYSTSVDVWSIGCIFAEMLT--------RRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVSQLPDYKSTFPRWA----NQELTKVVPTLNFEGRDLLALMLQYDPNQRVTANMALSHCFFQNVK 290
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: PHO85 (Cyclin-dependent kinase; has ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle; human lissencephaly-associated homolog CDK5 functionally complements null mutation [Source:SGD;Acc:S000005952]) HSP 1 Score: 158.688 bits (400), Expect = 2.367e-43 Identity = 94/330 (28.48%), Postives = 164/330 (49.70%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-----FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDA--ADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQA 3799
F + +G G++ +++ ++K + + VALK + L ++++G P +REI L K L H N+++ D++ E VFE++++DL + S ++ ++ + + QL LA+ H+ I+HRD+ P NL+++K G LKL DFG AR V + + V YRAP++LM Y T +DIWS GC++ E++TG L+ + E L+ + I+G+PN S+WP VTK ++ + + + + ++ + K P D D L + Q + R++AK AL W + A
Sbjct: 6 QFKQLEKLGNGTYATVYKGLNKTTGVYVALKEVKL-DSEEGTPSTAIREISLMKELKHENIVRLYDVIHTE----------------NKLTLVFEFMDNDLKKYMDSRTVGNTPRGLELNLVKYFQWQLLQGLAFCHENKILHRDLKPQNLLINKRGQLKLGDFGLARAFGIPVN-----TFSSEVVTLWYRAPDVLMGSRTYSTSIDIWSCGCILAEMITGKPLFPGTNDE--------EQLKLIFDIMGTPNESLWPSVTKLPKYNPNIQQRPPRDLRQVLQPHTKE-PLDGNLMDFLHGLLQLNPDMRLSAKQALHHPWFAEYYHHA 304
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: CTK1 (Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; required for H3K36 trimethylation but not dimethylation by Set2p; suggested stimulatory role in 80S formation during translation initiation; similar to the Drosophila dCDK12 and human CDK12 and probably CDK13 [Source:SGD;Acc:S000001622]) HSP 1 Score: 163.696 bits (413), Expect = 5.668e-43 Identity = 94/313 (30.03%), Postives = 160/313 (51.12%), Query Frame = 2
Query: 2843 IRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLK-QIFQWDSSKRITAKGALTSNWL 3778
I +G G++GK+++A + + VALK++ L +G P +REI L +S +H NV +I+V K+ Y +FEY ++DL GLL + + S SQ L KQL + Y+HD I+HRD+ SN+++ G LK+ DFG AR ++++ T + + YR PE+L+ NYGTEVD+W GC++ E+ + ++ E E +E++ KI+G+P + WP + +F ++ + + E++ +P L + +D +KR +A AL S++
Sbjct: 186 IMQVGEGTYGKVYKAKNTNTEKLVALKKLRLQGEREGFPITSIREIKLLQSFDHPNVSTIKEIMVES---------------QKTVYMIFEYADNDLSGLLLNKEVQISHSQCKHLFKQLLLGMEYLHDNKILHRDVKGSNILIDNQGNLKITDFGLAR------KMNSRADYTNRVITLWYRPPELLLGTTNYGTEVDMWGCGCLLVELFNKTAIFQGSNE--------LEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKYVNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFSATEALQSDYF 469
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: CDC28 (Cyclin-dependent kinase (CDK) catalytic subunit; master regulator of mitotic and meiotic cell cycles; alternately associates with G1, S, G2/M phase cyclins, which provide substrate specificity; regulates metabolism, basal transcription, chromosome dynamics, growth and morphogenesis; transcript induction in osmostress involves antisense RNA; human homologs CDK1, CDK2, CDK3 can complement yeast conditional cdc28 mutants; human CDK1, CDK2 can complement yeast cdc28 null mutant [Source:SGD;Acc:S000000364]) HSP 1 Score: 142.895 bits (359), Expect = 5.553e-38 Identity = 94/323 (29.10%), Postives = 160/323 (49.54%), Query Frame = 2
Query: 2816 SKSLYNFNLIRVIGVGSFGKIFEAVD---KFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDL----HGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRK-IEEYMKTIPYDAADVLKQIFQWDSSKRITAKGA 3760
S L N+ + +G G++G +++A+D VALK+I L + D+G+P +REI L K L N+++ DIV ++ + Y VFE+++ DL G+ K + + QL +AY H I+HRD+ P NL+++K G LKL DFG AR ++ A T + V YRAPE+L+ + Y T VD WS GC+ E+ ++ + +S + + + ++LG+PN ++WPD+ Y D + + RK + + + ++ D+L ++ +D RI+A+ A
Sbjct: 2 SGELANYKRLEKVGEGTYGVVYKALDLRPGQGQRVVALKKIRLESEDEGVPSTAIREISLLKELKDDNIVRLYDIVHSDAHKL---------------YLVFEFLDLDLKRYMEGIPKDQPL--GADIVKKFMMQLCKGIAYCHSHRILHRDLKPQNLLINKDGNLKLGDFGLARAFGVPLR-----AYTHEIVTLWYRAPEVLLGGKQYSTGVDTWSIGCIFAEMCN--------RKPIFSGDSEIDQIFKIFRVLGTPNEAIWPDIV---YLPDF--KPSFPQWRRKDLSQVVPSLDPRGIDLLDKLLAYDPINRISARRA 289
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: SGV1 (Cyclin (Bur2p)-dependent protein kinase; part of the BUR kinase complex which functions in transcriptional regulation; phosphorylates the carboxy-terminal domain (CTD) of Rpo21p and the C-terminal repeat domain of Spt5p; recruits Spt6p to the CTD at the onset of transcription; regulated by Cak1p; similar to metazoan CDK9 proteins [Source:SGD;Acc:S000006365]) HSP 1 Score: 145.976 bits (367), Expect = 2.198e-36 Identity = 103/341 (30.21%), Postives = 163/341 (47.80%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSI-KSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARL-------LTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKI-EEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSE---FPDKDCHE 3838
+G G+FG++++ + + +VA+K+I ++ D P REI + K LNH N+I+ +++V + I + SNL KSFY + Y+ DL G+L + + M I + Q+ L YIH +HRDI +N+++ G+LKLADFG ARL L + T V YRAPE+++ + Y T VDIW GCV E EK+ + ++ + + K+LG+P W V + ++L + NY + E + K + D L Q+ D KR+TA A W + +PSE P ++ HE
Sbjct: 66 LGQGTFGEVYKGIHLETQRQVAMKKIIVSVEKDLFPITAQREITILKRLNHKNIIKLIEMVYDHSPDITNAASSNLH----KSFYMILPYMVADLSGVLHNPRINLEMCDIKNMMLQILEGLNYIHCAKFMHRDIKTANILIDHNGVLKLADFGLARLYYGCPPNLKYPGGAGSGAKYTSVVVTRWYRAPELVLGDKQYTTAVDIWGVGCVFAEFF--------EKKPILQGKTDIDQGHVIFKLLGTPTEEDW-AVARYLPGAELTT----TNYKPTLRERFGKYLSETGLDFLGQLLALDPYKRLTAMSAKHHPWF----KEDPLPSEKITLPTEESHE 385
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Match: HOG1 (Mitogen-activated protein kinase involved in osmoregulation; controls global reallocation of RNAPII during osmotic shock; mediates recruitment/activation of RNAPII at Hot1p-dependent promoters; binds calmodulin; stimulates antisense transcription to activate CDC28; defines novel S-phase checkpoint with Mrc1p that prevent replication/transcription conflicts; nuclear form represses pseudohyphal growth; autophosphorylates; protein abundance increases under DNA replication stress [Source:SGD;Acc:S000004103]) HSP 1 Score: 137.117 bits (344), Expect = 9.811e-35 Identity = 99/317 (31.23%), Postives = 155/317 (48.90%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKS---KYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNW 3775
+N + +G+G+FG + A D ++ VA+K+I + + + RE+ L K L H N+I DI + S LE I YFV E DLH LL++ + Q + Q+ L Y+H +IHRD+ PSN+++++ LK+ DFG AR+ +D Q+ ++ YRAPEI++ + Y EVDIWSAGC+ E++ G L+ + + +LGSP V + K+ + L R I +S E KT+ DA D+L+++ +D KRITA AL +
Sbjct: 23 YNDLNPVGMGAFGLVCSATDTLTSQPVAIKKIMKPFSTAVLAKRTYRELKLLKHLRHENLICLQDIFL----------SPLEDI-----YFVTELQGTDLHRLLQTRPLEKQFVQ--YFLYQILRGLKYVHSAGVIHRDLKPSNILINENCDLKICDFGLARI--QDPQMTGYVSTR------YYRAPEIMLTWQKYDVEVDIWSAGCIFAEMIEGKPLFP--------GKDHVHQFSIITDLLGSPPKDVINTICSENTLKFVTSLPHRD-PIPFS----ERFKTVEPDAVDLLEKMLVFDPKKRITAADALAHPY 301
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO46173 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQW1]) HSP 1 Score: 198.749 bits (504), Expect = 8.899e-57 Identity = 109/317 (34.38%), Postives = 171/317 (53.94%), Query Frame = 2
Query: 2834 FNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVD 3784
F++I IG G++G++++A DK + V LK++ N +G P +REI + LNH N+I +IV ++ ++ + +FY VFEY++HDL GLL+S + + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + D T K + YR PE+L+ E YG +DIWS GC++ E+ T ++ +E LE ++++ G+P P+VWP + +F + + Y R+I E +P DA D+ + D S+RITA+ AL +L D
Sbjct: 2 FDIIEQIGEGTYGQVYKAKDKITGELVGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKPNALDFRKDK------GAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARL----YEADERRPYTNKVITLWYRPPELLLGEERYGPGIDIWSVGCILAELFTKKPIFPAYQE--------IGQLELISRVCGTPTPAVWPSIINLPHFHSIKPKR---QYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFLTD 297
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO41403 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4F0]) HSP 1 Score: 173.711 bits (439), Expect = 3.665e-48 Identity = 105/326 (32.21%), Postives = 165/326 (50.61%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKS-NSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMM 3805
NF + IG G++G +++A DK + VALK+I L +G+P +REI L K LNH NV+ +D+V N+ KS Y VFE++ DL + S S I QL S +AY H ++HRD+ P NL++ K G +KLADFG AR V+ + T + V YRAPEIL+ Y T VD+WS GC+ E+ T + L +S + L + + LG+P+ VWP V++ + + + I + T+ A D+L+++ + + RI+AK AL+ + D++ + ++
Sbjct: 3 NFEKVEKIGEGTYGVVYKARDKTTGRMVALKKIRLDTESEGVPSTAIREISLLKELNHPNVVSLLDVVHNQ----------------KSLYLVFEFLSQDLKKYMDCLPPSGISTSLIKSYVYQLLSGVAYCHSHRVLHRDLKPQNLLIDKNGAIKLADFGLARAFGVPVR-----SYTHEVVTLWYRAPEILLGSRYYATPVDVWSIGCIFAEMKT--------RRALFPGDSEIDQLFRIFRTLGTPDDKVWPGVSELPDYKTSFPKWPV----QSIRHVLPTLDNTAIDLLQKMLTYQPNARISAKAALSHEFFKDVQRKILI 295
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO34765 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SNE8]) HSP 1 Score: 171.014 bits (432), Expect = 2.454e-46 Identity = 102/312 (32.69%), Postives = 169/312 (54.17%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLR-VALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYD--AADVLKQIFQWDSSKRITAKGALTSNWL 3778
IG G+FG++F+A ++ + VALK++ + N +G P LREI + + LNH NV++ + EI K++ N S Y VFE+ EHDL GLL + ++ FS ++ + + L +AL +IH I+HRD+ +N++++K G+LKLA+FG AR + + + T + V YR PE+L+ NYG +D+W AGC++ E LWT + + + L ++ + GS P VWP V K + F +V + R+++E ++ D A D++ ++ D RI A AL ++
Sbjct: 23 IGQGTFGEVFKAKNRKNPKEIVALKKVLMDNEKEGFPITALREIKILQLLNHENVVKLL-----EICRTKAQPFNRNK---ASIYLVFEFCEHDLAGLLNNQAVKFSPPEMKKIMQMLLNALYFIHSNKILHRDMKAANILITKNGVLKLAEFGLARAI--HINKEQKQRYTNRVVTLWYRPPELLLGERNYGPPIDLWGAGCIMAE------LWT--RTPIMQGNTEQHQLTLISHLCGSITPEVWPGVDKLELFDKMV---LPSGQKRRVKERLRMYVKDHNALDLIDKMLSLDPGPRIDADSALNHDYF 313
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO28453 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T6F2]) HSP 1 Score: 163.696 bits (413), Expect = 7.305e-45 Identity = 99/303 (32.67%), Postives = 153/303 (50.50%), Query Frame = 2
Query: 2912 VALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSA-GCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEF 3817
V LK++ N +G P +REI + LNH N+I +IV ++ ++ + +FY VFEY++HDL GLL+S + + I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + D T K + YR PE+L+ E YG +DIWS G + I+ S D S + ++ ++ G+P P+VWP + +F + + Y R+I E +P DA D+ + D S+RITA+ AL +L D+ ++P +
Sbjct: 4 VGLKKVRTDNEKEGFPITAVREIKILCQLNHPNIINLKEIVTDKPNALDFRKDK------GAFYLVFEYMDHDLMGLLESGLVHLTEDHIKSFIRQLLDGLNYCHKKNFLHRDIKCSNILLNNKGEIKLADFGLARL----YEADERRPYTNKVITLWYRPPELLLGEERYGPGIDIWSCLGEMSSAIIVSS----------GDELSHY----SVYRVCGTPTPAVWPSIINLPHFHSIKPKR---QYRRRIREEFNFLPEDALDLFDAMLTLDPSQRITAEKALEHPFLTDVNPHNIIPPRY 279
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Match: EDO49420 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RGF7]) HSP 1 Score: 163.31 bits (412), Expect = 1.517e-44 Identity = 93/321 (28.97%), Postives = 160/321 (49.84%), Query Frame = 2
Query: 2825 LYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDI 3787
+ ++ + IG G++G +F+ +K + +ALKR+ L + D+G+P + LREI L K L H+N+++ D++ +E K VFE+ + DL S S + QL LA+ H N++HRD+ P NL+++K G LKLADFG AR V+ + + V YR P++LM + Y T +D+WSAGC+ E+ G L + L + KILG+P WP+V+K + + +G +++ + + T D+L+++ + + RI+A+ A+ + D+
Sbjct: 1 MQKYDKLEKIGEGTYGTVFKGKNKETREILALKRVRLDDDDEGVPSSALREICLLKELKHNNIVRLYDVLHSE----------------KKLTLVFEFCDQDLKKYFDSCQGEVDASVVKSFMFQLLRGLAFCHSHNVLHRDLKPQNLLINKDGELKLADFGLARAFGIPVR-----CFSAEVVTLWYRPPDVLMGAKLYSTSIDMWSAGCIFAEMANGG-------RPLFPGNDVDDQLRRIFKILGTPTEESWPNVSKLPDYKEFPPQGPSVSLGMVVPKLSST----GRDLLQKLLVSNPAHRISAEDAMKHAYFADL 289
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk12 (cyclin-dependent kinase 12 [Source:NCBI gene;Acc:101169207]) HSP 1 Score: 239.195 bits (609), Expect = 2.045e-63 Identity = 131/387 (33.85%), Postives = 213/387 (55.04%), Query Frame = 2
Query: 2696 GKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNES----KSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
G+S PP+ P +T+ K+PK+C R+ + N S + + F++I +IG G++G++++A DK + VALK++ L N +G P +REI + + L H +V+ +IV ++ ++ K +FY VFEY++HDL GLL+S + FS + +QL L Y H N +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E L LE ++++ GSP P+VWPDV K F+ + + Y R++ E +P A D+L ++ D ++R T++ ALTS++L D+E M P + P +DCHE
Sbjct: 653 GESSPPQSPVRQPPPLLPQMTLKKRPKICCPRYGERKHNLSDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLKHRSVVNMKEIVTDKQDALDFKKDK------GAFYLVFEYMDHDLMGLLESGLVQFSHEHVRSFMRQLMEGLDYCHKNNFLHRDIKCSNILLNNRGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELL--------QLELISRLCGSPCPAVWPDVIKLPLFNTMKPK---KQYRRRLREEFAFLPTPALDLLDRMLTLDPARRCTSEQALTSDFLCDVEPSKMPPPDLPHHQDCHEL 1018
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk13 (cyclin dependent kinase 13 [Source:NCBI gene;Acc:101169150]) HSP 1 Score: 227.639 bits (579), Expect = 7.762e-60 Identity = 127/367 (34.60%), Postives = 203/367 (55.31%), Query Frame = 2
Query: 2756 TVTKKPKLCSNR-HKIKSMN---ESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPD-KDCHEF 3841
T ++PK+C R +IK + + + F +I + G G++G++++A DK + VALK++ L N +G P +REI + + LNH ++I +IV ++ ++ F N + +FY VFEY++HDL GLL+S + F+ S I +QL L Y H KN +HRDI SN++++ G +KLADFG ARL + + T K + YR PE+L+ E Y +D+WS GC++ E+ T ++ +E LE +++I GSP P+VWPDV K +F+ + + Y R++ E IP A D+ + D +R TA+ AL+S +L D++ M P + P +DCHE
Sbjct: 606 TFRRRPKICGPRFGEIKEIEIDWGKRCVDKFEIIGITGEGTYGQVYKAKDKDTGEMVALKKVRLDNEKEGFPITAIREIKILRQLNHKSIINMKEIVTDKEDALD--FRNDKG----AFYLVFEYMDHDLMGLLESGLVHFNESHIKSFMRQLLEGLDYCHKKNFLHRDIKCSNILLNNRGQIKLADFGLARLYNS----EESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANQE--------LAQLELISRICGSPCPAVWPDVIKLPFFNTMKPK---KQYRRRLREEFAFIPPAALDLFDHMLNLDPGRRCTAEQALSSEFLKDVDPDKMPPPDLPLWQDCHEL 951
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk2 (cyclin dependent kinase 2 [Source:NCBI gene;Acc:101161880]) HSP 1 Score: 165.236 bits (417), Expect = 9.213e-45 Identity = 97/325 (29.85%), Postives = 165/325 (50.77%), Query Frame = 2
Query: 2831 NFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMI-FSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPY---DAADVLKQIFQWDSSKRITAKGALTSNWLVDIEM 3793
F + IG G++G +++A +K + VALK+I L +G+P +REI L K L+H N+++ D++ E Y VFE++ DL + S+S+ ++ + QL LA+ H ++HRD+ P NL+++ G +KLADFG AR V+ T + V YRAPEIL+ + Y T VD+WS GC+ E++T + L +S + L + + LG+P+ + WP VT + + ++R ++ K +P D ++L ++ ++D +KR++AK AL + D+ M
Sbjct: 3 TFQKVEKIGEGTYGVVYKAKNKLTGETVALKKIRLDTETEGVPSTAIREISLLKELSHPNIVKLQDVIHTE----------------NKLYLVFEFLHQDLKKFMDSSSVTGIPLALVKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAQGEIKLADFGLARAFGVPVR-----TYTHEVVTLWYRAPEILLGCKYYSTAVDVWSLGCIFAEMIT--------RRALFPGDSEIDQLFRIFRTLGTPDETAWPGVTSMPDYKPSFPK-----WAR--QDLSKVVPLLDEDGRELLGEMLKYDPNKRLSAKNALVHRFFRDVTM 291
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk4 (cyclin dependent kinase 4 [Source:NCBI gene;Acc:101172808]) HSP 1 Score: 162.925 bits (411), Expect = 1.298e-43 Identity = 107/334 (32.04%), Postives = 177/334 (52.99%), Query Frame = 2
Query: 2804 SMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSL---NHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLL-KSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWP-DVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
SM + L + + IG G++G +++A D S VALK + + +G+P + +RE+ L K L +H NV++ +D+ +K S+ ET V VFE+V+ DL L ++ + S ++ L KQL S L+++H ++HRD+ P N++V+ G +KLADFG AR+ + ++ALTP V YR PE+L++ +Y T VDIWS GC+ E+ ++ L ES + L + ++LG P WP DVT S+ + + ++R I +++ I + A +L Q+ +D KR++A AL + D E
Sbjct: 10 SMAQCTGL-QYEPVAEIGGGAYGTVYKARDIESGKFVALKNVRVQTDQNGLPVSTVREVALLKRLEQFDHPNVVRLMDVCA-------TKRSDQETKV----TLVFEHVDQDLKTYLERAPAPGLSPERVKDLMKQLLSGLSFLHSNRVMHRDLKPENILVTSQGQVKLADFGLARIYS------CHMALTPVVVTLWYRPPEVLLQ-SSYATPVDIWSTGCIFAEMF--------RRKPLFCGESEMDQLGKIFEVLGLPPEEEWPTDVTVSR-------KNFPLLHARPITDFVPEINEEGAQLLLQMLTFDPLKRVSAVKALEHPYFQDEE 309
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Match: cdk4 (cyclin dependent kinase 4 [Source:NCBI gene;Acc:101172808]) HSP 1 Score: 161.77 bits (408), Expect = 2.607e-43 Identity = 104/318 (32.70%), Postives = 171/318 (53.77%), Query Frame = 2
Query: 2852 IGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSL---NHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLL-KSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWP-DVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIE 3790
IG G++G +++A D S VALK + + +G+P + +RE+ L K L +H NV++ +D+ +K S+ ET V VFE+V+ DL L ++ + S ++ L KQL S L+++H ++HRD+ P N++V+ G +KLADFG AR+ + ++ALTP V YR PE+L++ +Y T VDIWS GC+ E+ ++ L ES + L + ++LG P WP DVT S+ + + ++R I +++ I + A +L Q+ +D KR++A AL + D E
Sbjct: 15 IGGGAYGTVYKARDIESGKFVALKNVRVQTDQNGLPVSTVREVALLKRLEQFDHPNVVRLMDVCA-------TKRSDQETKV----TLVFEHVDQDLKTYLERAPAPGLSPERVKDLMKQLLSGLSFLHSNRVMHRDLKPENILVTSQGQVKLADFGLARIYS------CHMALTPVVVTLWYRPPEVLLQ-SSYATPVDIWSTGCIFAEMF--------RRKPLFCGESEMDQLGKIFEVLGLPPEEEWPTDVTVSR-------KNFPLLHARPITDFVPEINEEGAQLLLQMLTFDPLKRVSAVKALEHPYFQDEE 299
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000046067.1 (SMESG000046067.1) HSP 1 Score: 2890.91 bits (7493), Expect = 0.000e+0 Identity = 1409/1413 (99.72%), Postives = 1411/1413 (99.86%), Query Frame = 2
Query: 26 MDLILTSTDFQKTLNELCTFFMHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEISDHYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIVNIVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLDTVKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYLIDFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMIXXXXXXXSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA 4264
MDLILTSTDFQKTLNELCTFFMHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEIS+HYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIV IVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLD VKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYL+DFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMINNNNNANSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA
Sbjct: 1 MDLILTSTDFQKTLNELCTFFMHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEISEHYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIVKIVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLDNVKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYLVDFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMINNNNNANSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA 1413
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000046067.1 (SMESG000046067.1) HSP 1 Score: 2841.99 bits (7366), Expect = 0.000e+0 Identity = 1388/1392 (99.71%), Postives = 1390/1392 (99.86%), Query Frame = 2
Query: 89 MHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEISDHYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIVNIVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLDTVKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYLIDFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMIXXXXXXXSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA 4264
MHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEIS+HYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIV IVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLD VKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYL+DFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMINNNNNANSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA
Sbjct: 1 MHIFKDDEIPNLPEFDLLYAACPDERKLKVISFLISGAIDIFACQPNKFIKSFIGNKMGLWRTLIVRLCHNHRADKHHLPFEIDIIASKNKLIVESLIFEWPFCNEIISQMLQYLCEAFLGSNHVNQPYIDDYVSKYKPKYRRVEAIKCLVLAIKWVHNVQCSPCYEQTKDILKENILNMVLVSEVMMKNREGQFEEIWNEVVNQLDNYDEFNSSRIDSYPFYCQINPLLKSISDLIRHLFSEENCTDFSKTLNGFHEISEHYETPELWGLDLTNTILAALNTIMIEMVFRRCKMFPKICENNLKMFINAVAVKEPISQLLLMSEVNYWVERMKRKRVEIPVNITDYFSSQWRTTNTESELLINLEHYFTQVLNDESGNLAVPVLNSPNSCVTDKKQFQKLIINCLKSVTNTILTKDPYFPPISDAKMKLIVKIVENISKYYSIELQTYFCDKVCRILEKFNSSIFKTKDTNEEIDNKNIIIPILDNIDYKQYVSEIWKCVNLSNSFLKPISIQEYLIDLRHELFSQISLEHADRIISRIMFYTGWRFRLRPLDISSSELFRFHLVFNFLSQNILKRSWVDENLSFWMRKLSNVDHSKSVDKNPMPSSFQMEEFYNGTKLDNVKTHVIQILRGAKNISIPQFNELPFPVYKKGLETTKSILLILRSVFASLNETNHHKHDNARNWLSHRKALETDLHTICIKLDADRNQVLAELGYLVDFVTTSFGINENFGADSSYFNGVSGEDDSARSNYKRRSSIKLENLGSEKDQIDMETKQLTRQTSKRKLTDFDEDEINIHRKSSRINYYDNEDSGSDFPSKYESRVSEKTTLHSKVNFILSSSDISLGEMIESRITYINEPNFKSICIDPGKGKSRPPRYIEISACPNRTPITVTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFPDKDCHEFLLENGDIQPIIDDNQMNQSEASIEDNMNALYAPQMINNNNNANSTIGSNEAPDFHSGNEEEVKDEDLKNFVNKLSKKILELGDVLDRMRTEPVCTPDIVKGVIMRAARVWSDTEGIRIRMVTFMLDYLLRSDEKEHLGFLA 1392
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000078149.1 (SMESG000078149.1) HSP 1 Score: 245.358 bits (625), Expect = 8.721e-69 Identity = 131/362 (36.19%), Postives = 205/362 (56.63%), Query Frame = 2
Query: 2759 VTKKPKLCSNRHKIKSMNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+ K PK+C +R +IK N +S+ +F +I +G G++G +F+A+D+ +N ALK+I L N +G P +REI + LNH N+I ++V + SK K FY VFEY++HDL+G+L S + + +QI + KQ+ S + Y H + +HRDI SN++V+ G +K+ADFG AR D ++ T K + YRAPE+L+ E YG +D+WS GC++ E+ ++T E + LE ++K+ G+PN +WP+VTK F+ + NY R++ EY T+P+ A +VL + Q D +R + + AL S WL I+ + + P FP DKD HE
Sbjct: 139 IFKMPKICESRSRIK--NTERSVKSFKIIAEVGEGTYGHVFKAIDRQTNAMKALKKIRLENEREGFPITTVREIKILHKLNHPNIIYLNEVVTDYDSKSNSKV--------KGFYLVFEYMDHDLYGILDS-GITLNENQIASIMKQIISGICYCHKRKFLHRDIKSSNILVNNKGEVKIADFGLARKFEAD---NSKRPYTNKVITLWYRAPELLLGEEIYGEAIDVWSIGCIMGELFVRRTMFTASNE--------MDQLETISKVCGTPNAGIWPNVTKLPLFATFRPK---CNYKRRLREYYCTLPHSALEVLDWMLQLDPKRRCSTEQALNSYWLRKIDPKQIPPPAFPADKDYHEL 475
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000057162.1 (SMESG000057162.1) HSP 1 Score: 234.958 bits (598), Expect = 1.990e-63 Identity = 128/366 (34.97%), Postives = 204/366 (55.74%), Query Frame = 2
Query: 2753 ITVTKKPKLCSNRHKIKS--MNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+++ KKP +C+ R ++ +S+ F I +G G++G +F+A D + ALK++ L N +G P +REI + L H+N++ +IV + ++ K +FY VF+Y++HDL G+L+S S+I + Q+ + KQL + Y H +N +HRDI SN++V+ G +KLADFG ARL D D T K + YR PE+L+ E Y +DIWS GC++ E+ TG ++T +E E +E+++K+ G PN + WP VT+ F R NY R++ E+ T+P A D+L + + D KR TA AL S+WL +++ + + P +FP D+DCHE
Sbjct: 332 VSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDK------GAFYLVFDYMDHDLFGILESKSVI-TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIAD---DKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEE--------MEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRH---NYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHEL 676
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Match: SMESG000057162.1 (SMESG000057162.1) HSP 1 Score: 234.572 bits (597), Expect = 2.071e-63 Identity = 128/366 (34.97%), Postives = 204/366 (55.74%), Query Frame = 2
Query: 2753 ITVTKKPKLCSNRHKIKS--MNESKSLYNFNLIRVIGVGSFGKIFEAVDKFSNLRVALKRISLANTDDGIPQAILREILLYKSLNHSNVIQFVDIVVNEIMSIKSKFSNLETIVPKSFYFVFEYVEHDLHGLLKSNSMIFSMSQIGFLSKQLFSALAYIHDKNIIHRDITPSNLMVSKCGILKLADFGNARLLTKDVQLDNNLALTPKTVPYLYRAPEILMEVENYGTEVDIWSAGCVIYEILTGSLLWTIEKENLSDNESAFEHLENMAKILGSPNPSVWPDVTKSKYFSDLVSRGIAINYSRKIEEYMKTIPYDAADVLKQIFQWDSSKRITAKGALTSNWLVDIEMQAMMPSEFP-DKDCHEF 3841
+++ KKP +C+ R ++ +S+ F I +G G++G +F+A D + ALK++ L N +G P +REI + L H+N++ +IV + ++ K +FY VF+Y++HDL G+L+S S+I + Q+ + KQL + Y H +N +HRDI SN++V+ G +KLADFG ARL D D T K + YR PE+L+ E Y +DIWS GC++ E+ TG ++T +E E +E+++K+ G PN + WP VT+ F R NY R++ E+ T+P A D+L + + D KR TA AL S+WL +++ + + P +FP D+DCHE
Sbjct: 326 VSLMKKPGICAKRSATRNNVTWGERSVSAFRFIDKVGEGTYGHVFKAEDIQTGELKALKKVRLENEKEGFPITAIREIKILMQLVHANIVNLCEIVTDIDNALDFKKDK------GAFYLVFDYMDHDLFGILESKSVI-TDEQVASIFKQLLEGIQYCHSRNFLHRDIKCSNILVNNRGEIKLADFGLARLYIAD---DKKRPYTNKVITLWYRPPELLLGEECYSPAIDIWSLGCILGELFTGQTMFTASEE--------MEQMESISKVCGVPNVNDWPKVTRLPLFESYKPRH---NYKRRLREHYCTLPSRALDLLDWMLRLDPEKRCTATQALKSDWLRNVDSKKIKPPDFPRDRDCHEL 670 The following BLAST results are available for this feature:
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Cyclin-dependent kinase 12 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019786 ID=SMED30019786|Name=Cyclin-dependent kinase 12|organism=Schmidtea mediterranea sexual|type=transcript|length=4402bpback to top protein sequence of SMED30019786-orf-1 >SMED30019786-orf-1 ID=SMED30019786-orf-1|Name=SMED30019786-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1415bp MMDLILTSTDFQKTLNELCTFFMHIFKDDEIPNLPEFDLLYAACPDERKLback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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