NAD-dependent protein deacylase

Overview
NameNAD-dependent protein deacylase
Smed IDSMED30019748
Length (bp)1525
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of NAD-dependent protein deacylase (SMED30019748) t-SNE clustered cells

Violin plots show distribution of expression levels for NAD-dependent protein deacylase (SMED30019748) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NAD-dependent protein deacylase (SMED30019748) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NAD-dependent protein deacylase (SMED30019748) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30019748

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 2

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30019748h1SMcG0006762 dd_Smed_v4_1992_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Category 4 cellSMED30019748h1SMcG0006762 dd_Smed_v4_1992_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 273.478 bits (698), Expect = 8.880e-88
Identity = 130/264 (49.24%), Postives = 182/264 (68.94%), Query Frame = 1 
Query:   37 SQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            S  +F++    AK+I++I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PNA H A+++ E +  K+ ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++SIP E LP CE   C GLLRP+VVWFGENL P  LE+    + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN E+T  + + ++  +GP  +TLP  L
Sbjct:   39 SMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEAL 301
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 261.536 bits (667), Expect = 2.633e-83
Identity = 124/250 (49.60%), Postives = 173/250 (69.20%), Query Frame = 1 
Query:   37 SQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQY 777
            S  +F++    AK+I++I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PNA H A+++ E +  K+ ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++SIP E LP CE   C GLLRP+VVWFGENL P  LE+    + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN E+T  + +  +
Sbjct:   39 SMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFSH 287
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 251.136 bits (640), Expect = 2.569e-79
Identity = 122/263 (46.39%), Postives = 171/263 (65.02%), Query Frame = 1 
Query:   37 SQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            S  +F++    AK+I++I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PNA H A+++ E +  K+ ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG                 CE   C GLLRP+VVWFGENL P  LE+    + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN E+T  + + ++  +GP  +TLP  L
Sbjct:   39 SMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKG-----------------CEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEAL 283
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 194.897 bits (494), Expect = 7.250e-59
Identity = 93/188 (49.47%), Postives = 128/188 (68.09%), Query Frame = 1 
Query:  265 PNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            PNA H A+++ E +  K+ ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++SIP E LP CE   C GLLRP+VVWFGENL P  LE+    + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN E+T  + + ++  +GP  +TLP  L
Sbjct:    6 PNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEAL 193
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT4 (sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932])

HSP 1 Score: 105.916 bits (263), Expect = 1.240e-24
Identity = 76/252 (30.16%), Postives = 123/252 (48.81%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKA----NPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKN------VKENF--ISPI----CEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            E ++ + L+K +LV+TGAGIS +SGIP +R  +   +   +   +         P  + + Y  R  +         PN AH ALS +E    K  K + L+TQNVD LH +AGS  +  +HG +    C+ C        ++E F  ++P       GL   GD   +E   +    +PTC  C G L+P+VV+FG+ ++PD ++  +  +K  D  +V+G+S  V     F      + +P+A  N+  T
Sbjct:   46 ELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAP--IRQRYWARNFVGWPQFSSHQPNPAHWALSTWE----KLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQ-VRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPT 290
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.3 (NAD-dependent protein deacylase sir-2.3 [Source:UniProtKB/Swiss-Prot;Acc:Q20481])

HSP 1 Score: 102.834 bits (255), Expect = 2.764e-24
Identity = 77/246 (31.30%), Postives = 114/246 (46.34%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENP---SLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNV-----------------KENFISPICEGL-RDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRG 720
            +FK  +     +L+ITGAGIS +SGIP +R S+ +      +        F+++       W   +       +A PN  H ALSK+E      NK   LITQNVDGLH +AGS+ I  +HG   + KC  C+ +                 KE F+SP  + L  D   P  +E        +P C  C GL++ +V  FGENL+ D ++     +  C+  + +GTS  V       YQ++N  
Sbjct:   19 KFKSLVGTVDKLLIITGAGISTESGIPDYR-SKDVGLYTKTALEPIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEA----ANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGF----KIPECLNCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLS----GYQIVNHA 251
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 98.2117 bits (243), Expect = 1.080e-22
Identity = 73/263 (27.76%), Postives = 115/263 (43.73%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFR----------GSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEE-----------------SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            +F   +     +LVI+GAGIS +SGIP +R            + + +++Y   N      +  N  L W  +        +A PN  H ALSK+E   + +     LITQNVDGLH +AGS+ +  +HG   + KC  C  ++        +   D  +P   E    P E                  +P C  C GL++ +V +FGEN++ D +   Y+ +  CD  + +GTS  V     F +    +  P+   N+  T
Sbjct:   19 KFISLIGTVDKLLVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRN-FLAWPRFG-------QAAPNINHYALSKWEASDRFQ----WLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESR---QTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPT 266
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 93.5893 bits (231), Expect = 5.971e-21
Identity = 73/265 (27.55%), Postives = 115/265 (43.40%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADS--GIPTFR----------GSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEE-----------------SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            +F   +     +LVI+GAGIS +S  GIP +R            + + +++Y   N      +  N  L W  +        +A PN  H ALSK+E   + +     LITQNVDGLH +AGS+ +  +HG   + KC  C  ++        +   D  +P   E    P E                  +P C  C GL++ +V +FGEN++ D +   Y+ +  CD  + +GTS  V     F +    +  P+   N+  T
Sbjct:   24 KFISLIGTVDKLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRN-FLAWPRFG-------QAAPNINHYALSKWEASDRFQ----WLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESR---QTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPT 273
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 93.2041 bits (230), Expect = 6.653e-21
Identity = 73/265 (27.55%), Postives = 115/265 (43.40%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADS--GIPTFR----------GSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEE-----------------SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            +F   +     +LVI+GAGIS +S  GIP +R            + + +++Y   N      +  N  L W  +        +A PN  H ALSK+E   + +     LITQNVDGLH +AGS+ +  +HG   + KC  C  ++        +   D  +P   E    P E                  +P C  C GL++ +V +FGEN++ D +   Y+ +  CD  + +GTS  V     F +    +  P+   N+  T
Sbjct:   19 KFISLIGTVDKLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRN-FLAWPRFG-------QAAPNINHYALSKWEASDRFQ----WLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESR---QTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPT 268
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.1 (NAD-dependent protein deacetylase sir-2.1 [Source:UniProtKB/Swiss-Prot;Acc:Q21921])

HSP 1 Score: 93.5893 bits (231), Expect = 6.096e-20
Identity = 76/252 (30.16%), Postives = 117/252 (46.43%), Query Frame = 1 
Query:   31 YMSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRAL--RWRNY-----ESCNLATLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPT----CEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVES 750
            Y S  +  +  K  K+ILV+TGAG+S   GIP FR    +  R R+      +   +  +  F ENP+    FY+F REI   +  P+ +H  + + E       +     TQN+D L  + G + ++  HG   +  C +C                 K D N      I EE L      C+ C G+++PN+V+FGE+L  +  +   +     DL VVIG+S  V+PVA  P+  +++ VP    N ES
Sbjct:  132 YNSLADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPA---PFYNFAREIFPGQFVPSVSHRFIKELETS----GRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQ---------------KYDGNE-----IREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKVRPVALIPH-CVDKNVPQILINRES 355
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070852)

HSP 1 Score: 87.8113 bits (216), Expect = 7.906e-19
Identity = 61/207 (29.47%), Postives = 106/207 (51.21%), Query Frame = 1 
Query:   76 NILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICL----KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKC-----KNVKENFISPICEGLRDKGD---PNSTENSSIPEE-----SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCD 645
            N+LV+TGAGIS +SGIP +R      +       +  +  F+++ S V + Y  R  +         PNA H AL++FE    +E +   ++TQNVD LH +AGS N++ +HG  +  KC+ C     ++  ++ ++ +    +D  D   P+   +  IP E      +P C  C G L+P +V+FG+++    +++    + N D
Sbjct:   47 NVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHM-EFVKS-SAVRKRYWARNFVGWPKFSATQPNATHHALARFE----REERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDG--DVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSD 245
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt1 (gene:FBgn0024291 transcript:FBtr0080434)

HSP 1 Score: 88.9669 bits (219), Expect = 2.629e-18
Identity = 70/237 (29.54%), Postives = 111/237 (46.84%), Query Frame = 1 
Query:   61 LKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWE----------FYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCK------NVKENFIS---PICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKN-CDLCVVIGTSGIVQPVASFPYQV 708
            +K ++ I+V+TGAG+S   GIP FR +  +  R      LA     L +P  +++          FY F REI   +  P+  H  +   E K     K     TQN+D L R AG + +I  HG      C KC+       ++ +  +   P+C   +   + +   + ++ EE L       G+++P++V+FGE L PD         K+ CDL +VIG+S  V+PVA  P  +
Sbjct:  218 VKKSQKIIVLTGAGVSVSCGIPDFRSTNGIYAR------LAHDFPDLPDPQAMFDINYFKRDPRPFYKFAREIYPGEFQPSPCHRFIKMLETK----GKLLRNYTQNIDTLERVAGIQRVIECHGSFSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQL-VENGIMKPDIVFFGEGL-PDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSI 442
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0083882)

HSP 1 Score: 83.9593 bits (206), Expect = 2.819e-17
Identity = 63/217 (29.03%), Postives = 100/217 (46.08%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLA------TLPAFLENPSLVWEFYHFRREICLKAN-PNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF 696
            + I+ + GAGIS  +GIP FR   +  + N +   L        L  F +NP+    F+   +E+   +  P  AH  +     K   +       TQN+D L R  G   + II  HG      C+KC+  KE  +  +               + I  + LP C+ C+G+++P++V+FGENL         +  ++CDL +++GTS  VQP AS 
Sbjct:   48 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPA---PFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRH----YTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCR--KEYDMDWM--------------KAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASL 241
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0344243)

HSP 1 Score: 83.9593 bits (206), Expect = 2.819e-17
Identity = 63/217 (29.03%), Postives = 100/217 (46.08%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLA------TLPAFLENPSLVWEFYHFRREICLKAN-PNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF 696
            + I+ + GAGIS  +GIP FR   +  + N +   L        L  F +NP+    F+   +E+   +  P  AH  +     K   +       TQN+D L R  G   + II  HG      C+KC+  KE  +  +               + I  + LP C+ C+G+++P++V+FGENL         +  ++CDL +++GTS  VQP AS 
Sbjct:   48 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPA---PFFALAKELYPGSFIPTPAHYFIRLLNDKGLLQRH----YTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKCR--KEYDMDWM--------------KAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEVQPFASL 241
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070851)

HSP 1 Score: 72.4034 bits (176), Expect = 3.774e-14
Identity = 41/139 (29.50%), Postives = 74/139 (53.24%), Query Frame = 1 
Query:  262 NPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKC-----KNVKENFISPICEGLRDKGDPNSTE-NSSIPEE-----SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCD 645
             PNA H AL++FE    +E +   ++TQNVD LH +AGS N++ +HG  +  KC+ C     ++  ++ ++ +    +D  D    + +  IP E      +P C  C G L+P +V+FG+++    +++    + N D
Sbjct:   28 QPNATHHALARFE----REERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDMIRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSD 162
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:436878])

HSP 1 Score: 270.781 bits (691), Expect = 5.421e-87
Identity = 132/261 (50.57%), Postives = 175/261 (67.05%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 822
            F++    AK+I +ITGAG+SA+SG+PTFRG     WR +++ +LAT  AF  +PSLVWEFYH+RRE+     PN AH A+++ E +  ++ +   +ITQN+D LH RAGS+++  IHG +F+T+CM C  VK N  SPIC  L  KG P+ +T+ + IP E LP CE   C GLLRP+VVWFGE L  D L      ++ CDLC+V+GTS IV P A F  QV +RGVPVAEFN+E T  + + +Y   GP  STLPP LE
Sbjct:   39 FREHFAKAKHIAIITGAGVSAESGVPTFRGPGGF-WRKWQAQDLATPEAFSRDPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSVVIITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCGEVKANHKSPICPALDGKGAPDPNTKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAVERELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRFKYHFEGPCGSTLPPALE 298
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 89.3521 bits (220), Expect = 5.573e-19
Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLE------NPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFT-LITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRGV--PVAEFNVESTDIS 762
            K I+V+ GAGIS  SGIP FR   +  + N +  NL    A  E      NP+    F+   +E+     P      L+ + ++   + +Q   + TQN+DGL R AG   + ++  HG      C  C+   +       E LRD           I   ++P C  C+G+++P++V+FGE L P             DL +V+GTS  V+P AS         P  +INR +  P A  +   TD++
Sbjct:  101 KRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPN---PFFALAKELY----PGNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKG------EELRD----------DIMAGTVPKCPTCKGIIKPDIVFFGEEL-PQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVA 325
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 89.3521 bits (220), Expect = 6.357e-19
Identity = 73/249 (29.32%), Postives = 112/249 (44.98%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLE------NPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFT-LITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRGV--PVAEFNVESTDIS 762
            K I+V+ GAGIS  SGIP FR   +  + N +  NL    A  E      NP+    F+   +E+     P      L+ + ++   + +Q   + TQN+DGL R AG   + ++  HG      C  C+   +       E LRD           I   ++P C  C+G+++P++V+FGE L P             DL +V+GTS  V+P AS         P  +INR +  P A  +   TD++
Sbjct:  101 KRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPN---PFFALAKELY----PGNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKG------EELRD----------DIMAGTVPKCPTCKGIIKPDIVFFGEEL-PQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVA 325
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 84.3445 bits (207), Expect = 6.680e-18
Identity = 70/244 (28.69%), Postives = 108/244 (44.26%), Query Frame = 1 
Query:   88 ITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLE------NPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFT-LITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRGV--PVAEFNVESTDIS 762
            + GAGIS  SGIP FR   +  + N +  NL    A  E      NP+    F+   +E+     P      L+ + ++   + +Q   + TQN+DGL R AG   + ++  HG      C  C+   +       E LRD           I   ++P C  C+G+++P++V+FGE L P             DL +V+GTS  V+P AS         P  +INR +  P A  +   TD++
Sbjct:    1 MAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPN---PFFALAKELY----PGNYQPNLTHYFIRMLHDKEQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKG------EELRD----------DIMAGTVPKCPTCKGIIKPDIVFFGEEL-PQHFFTYLTDFPIADLLIVMGTSLEVEPFASLAGAVRGSVPRLLINRDLVGPFASGSQRHTDVA 220
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 84.3445 bits (207), Expect = 1.606e-17
Identity = 64/249 (25.70%), Postives = 108/249 (43.37%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFR--GSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKC------KNVKENF--ISPICEGLRDKGDPNST---ENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            + +  +  A  + VI+GAG+S +SGIP +R  G       N      +      ++    W   +          PN+AH AL  +E K     K   L+TQNVD LH +AG + +  +HG      C+ C        +++ F  ++P  E       P+     E   +    +P C  C G+L+P V +FG+ +  +T+   ++ +   D  +V G+S  V     F      R +P+A  N+ +T
Sbjct:   42 QLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEK----GKLHWLVTQNVDALHLKAGQQRLTELHGSTHRVVCLDCGELTLRAELQKRFTALNPGWEATACAVAPDGDVFLEEEQVLNFRVPACNACGGVLKPEVTFFGDVVKRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASERKLPIAIVNIGAT 286
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BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: lin28a (lin-28 homolog A [Source:Xenbase;Acc:XB-GENE-491384])

HSP 1 Score: 276.174 bits (705), Expect = 7.217e-89
Identity = 131/261 (50.19%), Postives = 179/261 (68.58%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I VITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+ L  NPN AH A+++ E + +K+ ++  +ITQN+D LHR+AGS N+  IHG +F+T+C  C +VKEN+ SPIC  L  KG P    +++ IP E LP C+   C GLLRPNVVWFGE L  + L +    ++ CDLCVV+GTS +V P A F  QV  RGVPVAEFN+E+T  +    +  +GP  +TLPP +
Sbjct:   41 DFREAFAKAKHIAVITGAGVSAESGVPTFRGAGGY-WRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKNPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFEIHGSLFKTRCTSCGSVKENYKSPICPALAGKGAPEPDVQDAKIPVEQLPRCDENGCNGLLRPNVVWFGETLDSNLLGEVEKELEICDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTSFTFHFQGPCGTTLPPAI 300
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: SIRT3 (sirtuin 3 [Source:NCBI gene;Acc:100487410])

HSP 1 Score: 102.449 bits (254), Expect = 3.105e-23
Identity = 84/251 (33.47%), Postives = 106/251 (42.23%), Query Frame = 1 
Query:   67 LAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLA------TLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGP 792
            L + ILV+ GAGIS DSGIP FR   +  +   +  NL        L  FL  P     F H  R++     +PN AH  L     K         L TQN+DGL R AG  SE ++  HG      C  C                 K  P  T   ++ E  +P C  C GL++ ++V+FGE L P  L    D     DL  VIGTS  V+P AS  Y V     P    N +S      V  F+ GP
Sbjct:  101 LYRRILVMVGAGISTDSGIPDFRSPTSGLYSRLQEYNLPYPEAIFDLRYFLREPQ---PFLHLARDLLPGHHHPNTAHHFLRLLSDK----EVLLRLYTQNIDGLERAAGIPSEKLVEAHGSFSSATCTMCL----------------KSYPGETFQKAVMESKVPLCSSCGGLIKADIVFFGEQLPPRFLLHLTD-FPRADLLFVIGTSLEVEPFASLVYAV-RASTPRVLINRDS------VGPFVSGP 320
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: SIRT3 (sirtuin 3 [Source:NCBI gene;Acc:100487410])

HSP 1 Score: 102.064 bits (253), Expect = 3.302e-23
Identity = 84/251 (33.47%), Postives = 106/251 (42.23%), Query Frame = 1 
Query:   67 LAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLA------TLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGP 792
            L + ILV+ GAGIS DSGIP FR   +  +   +  NL        L  FL  P     F H  R++     +PN AH  L     K         L TQN+DGL R AG  SE ++  HG      C  C                 K  P  T   ++ E  +P C  C GL++ ++V+FGE L P  L    D     DL  VIGTS  V+P AS  Y V     P    N +S      V  F+ GP
Sbjct:   82 LYRRILVMVGAGISTDSGIPDFRSPTSGLYSRLQEYNLPYPEAIFDLRYFLREPQ---PFLHLARDLLPGHHHPNTAHHFLRLLSDK----EVLLRLYTQNIDGLERAAGIPSEKLVEAHGSFSSATCTMCL----------------KSYPGETFQKAVMESKVPLCSSCGGLIKADIVFFGEQLPPRFLLHLTD-FPRADLLFVIGTSLEVEPFASLVYAV-RASTPRVLINRDS------VGPFVSGP 301
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: tspear (thrombospondin-type laminin G domain and EAR repeats [Source:Xenbase;Acc:XB-GENE-6050978])

HSP 1 Score: 97.0561 bits (240), Expect = 9.149e-21
Identity = 80/251 (31.87%), Postives = 120/251 (47.81%), Query Frame = 1 
Query:   61 LKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRRE------ICLKANPNAAHAAL-SKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCR-----GLLRPNVVWFGENLHPDTLEKSYDAIKN-CDLCVVIGTSGIVQPVA----SFPYQV----INR-GVPVAEFNVE 747
            L+ +K I+V+TGAG+S   GIP FR    +  R      LA     L NP  +++  +FR++         +  P     +L  +F     KE K     TQN+D L + AG E II  HG   E  C+ CK   +      CE +R+           I  + +P C  C       +++P++V+FGENL P+   ++    KN  DL +VIG+S  V+PVA    S P++V    INR  +P   F++E
Sbjct:  124 LQESKKIIVLTGAGVSVSCGIPDFRSRDGIYAR------LAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVD------CEAVRE----------DIFNQIVPRCPRCSSDEPLAIMKPDIVFFGENL-PEQFHRAMKYDKNEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDIE 351
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: tspear (thrombospondin-type laminin G domain and EAR repeats [Source:Xenbase;Acc:XB-GENE-6050978])

HSP 1 Score: 97.0561 bits (240), Expect = 9.369e-21
Identity = 80/251 (31.87%), Postives = 120/251 (47.81%), Query Frame = 1 
Query:   61 LKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRRE------ICLKANPNAAHAAL-SKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCR-----GLLRPNVVWFGENLHPDTLEKSYDAIKN-CDLCVVIGTSGIVQPVA----SFPYQV----INR-GVPVAEFNVE 747
            L+ +K I+V+TGAG+S   GIP FR    +  R      LA     L NP  +++  +FR++         +  P     +L  +F     KE K     TQN+D L + AG E II  HG   E  C+ CK   +      CE +R+           I  + +P C  C       +++P++V+FGENL P+   ++    KN  DL +VIG+S  V+PVA    S P++V    INR  +P   F++E
Sbjct:  138 LQESKKIIVLTGAGVSVSCGIPDFRSRDGIYAR------LAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVD------CEAVRE----------DIFNQIVPRCPRCSSDEPLAIMKPDIVFFGENL-PEQFHRAMKYDKNEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDIE 365
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 264.618 bits (675), Expect = 1.552e-84
Identity = 125/261 (47.89%), Postives = 177/261 (67.82%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PN  H A+++ E + + + ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++ IP + LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV +RGVPVAEFN+E+T  + + ++   GP   TLP  L
Sbjct:   42 DFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPEAL 301
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 264.618 bits (675), Expect = 1.552e-84
Identity = 125/261 (47.89%), Postives = 177/261 (67.82%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PN  H A+++ E + + + ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++ IP + LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV +RGVPVAEFN+E+T  + + ++   GP   TLP  L
Sbjct:   42 DFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPEAL 301
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 254.218 bits (648), Expect = 8.930e-81
Identity = 119/239 (49.79%), Postives = 167/239 (69.87%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            +F++    AK+I +I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PN  H A+++ E + + + ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++ IP + LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV +RGVPVAEFN+E+T
Sbjct:   42 DFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETT 279
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 254.218 bits (648), Expect = 8.930e-81
Identity = 119/239 (49.79%), Postives = 167/239 (69.87%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            +F++    AK+I +I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PN  H A+++ E + + + ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++ IP + LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV +RGVPVAEFN+E+T
Sbjct:   42 DFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETT 279
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 254.603 bits (649), Expect = 4.414e-80
Identity = 120/253 (47.43%), Postives = 172/253 (67.98%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPA 795
            +F++    AK+I +I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PN  H A+++ E + + + ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++ IP + LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV +RGVPVAEFN+E+T  + + +  +  P 
Sbjct:   42 DFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFARNPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCGTVAENYRSPICPALAGKGAPEPETQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELALCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRVSLCSPG 293
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q5HZN8|SIR5A_XENLA (NAD-dependent protein deacylase sirtuin-5A, mitochondrial OS=Xenopus laevis OX=8355 GN=sirt5-a PE=2 SV=1)

HSP 1 Score: 281.567 bits (719), Expect = 3.719e-90
Identity = 134/261 (51.34%), Postives = 178/261 (68.20%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNS-TENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I VITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+ L  NPN AH A+++ E + +K+ ++  +ITQN+D LHR+AGS N+  IHG +F+T+C  C  VKEN+ SPIC  L  KG P S  +++ IP E LP CE   C GLLRPNVVWFGE L  + L +    ++ CDLCVV+GTS +V P A F  QV  RGVPVAEFN+E+T  +    +   GP  +TLPP L
Sbjct:   41 DFREAFAKAKHIAVITGAGVSAESGVPTFRGAGGY-WRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKNPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFDIHGSLFKTRCTSCGRVKENYKSPICPALDGKGAPESDVQDAKIPVEQLPRCEENGCSGLLRPNVVWFGETLDSNLLGEVEKELETCDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTSFTFHFHGPCGTTLPPAL 300
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|E1BRE2|SIR5_CHICK (NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Gallus gallus OX=9031 GN=SIRT5 PE=3 SV=1)

HSP 1 Score: 278.485 bits (711), Expect = 4.938e-89
Identity = 130/261 (49.81%), Postives = 181/261 (69.35%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +ITGAG+SA+SG+PTFRG+    WR +++  LAT  AF  NPS VWEFYH+RRE+ L  +PNAAH A+++ E + +K+ +   +ITQN+D LHR+AG+++++ IHG +F+T+C  C NV  N+ SPIC  L  KG P+   E+++IP E LP CE   C GLLRP+VVWFGE L PD L +    +  CDLC+V+GTS +V P A F  QV  RGVPVAEFN+E+T  + + ++   GP  +TLPP L
Sbjct:   41 DFREVFAKAKHIAIITGAGVSAESGVPTFRGAGGF-WRKWQAQELATPGAFARNPSRVWEFYHYRREVMLSKHPNAAHIAIAECEKRLRKQGRSVVVITQNIDELHRKAGTKHLLEIHGSLFKTRCTNCGNVTANYKSPICPALAGKGAPDPEIEDAAIPVEELPQCEEDGCHGLLRPHVVWFGETLDPDVLTEVEKELDLCDLCLVVGTSSVVYPAAMFAPQVSARGVPVAEFNMEATPATDRFRFHFEGPCGTTLPPAL 300
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|F7DKV7|SIR5_XENTR (NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Xenopus tropicalis OX=8364 GN=sirt5 PE=3 SV=1)

HSP 1 Score: 276.174 bits (705), Expect = 3.823e-88
Identity = 131/261 (50.19%), Postives = 179/261 (68.58%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I VITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+ L  NPN AH A+++ E + +K+ ++  +ITQN+D LHR+AGS N+  IHG +F+T+C  C +VKEN+ SPIC  L  KG P    +++ IP E LP C+   C GLLRPNVVWFGE L  + L +    ++ CDLCVV+GTS +V P A F  QV  RGVPVAEFN+E+T  +    +  +GP  +TLPP +
Sbjct:   41 DFREAFAKAKHIAVITGAGVSAESGVPTFRGAGGY-WRKWQAQHLATPEAFARNPSRVWEFYHYRREVMLTKNPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFEIHGSLFKTRCTSCGSVKENYKSPICPALAGKGAPEPDVQDAKIPVEQLPRCDENGCNGLLRPNVVWFGETLDSNLLGEVEKELEICDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTSFTFHFQGPCGTTLPPAI 300
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|E9GD30|SIR5_DAPPU (NAD-dependent protein deacylase OS=Daphnia pulex OX=6669 GN=DAPPUDRAFT_195469 PE=3 SV=1)

HSP 1 Score: 274.633 bits (701), Expect = 5.127e-88
Identity = 131/260 (50.38%), Postives = 178/260 (68.46%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTE-NSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            F++ LK A +++++TGAG+SA+SG+PTFRG+  L WR Y + NLAT  AF  NPSLVWEFYH RRE     +PN AH A+++FE +  KE +  ++ITQN+D LH+RAGS N++ +HG +F+T+C+KCK ++ N  SPICE LR KG P+  E    +PE  LP C+   C GLLRP+VVWF ENL    L+K+ + + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN+E+T  +    +   GP    LP  L
Sbjct:   14 FRKILKKANSVVILTGAGVSAESGVPTFRGAGGL-WRTYSAQNLATPSAFRSNPSLVWEFYHHRRENMASKSPNNAHNAIAEFEHRMTKEGRHVSVITQNIDELHQRAGSVNVLELHGSLFKTRCLKCKKIEPNHDSPICEALRGKGSPSPNEVGELVPESLLPRCKVSSCGGLLRPHVVWFHENLDSAVLKKADEELNSCDLCLVVGTSSVVYPAAMFAPQVAERGVPVAEFNMETTAATHHFGFHFSGPCGELLPKAL 272
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|F7EZ75|SIR5_MACMU (NAD-dependent protein deacylase sirtuin-5, mitochondrial OS=Macaca mulatta OX=9544 GN=SIRT5 PE=3 SV=1)

HSP 1 Score: 273.863 bits (699), Expect = 3.401e-87
Identity = 130/264 (49.24%), Postives = 181/264 (68.56%), Query Frame = 1 
Query:   37 SQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            S  +F++    AK+I++I+GAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+     PNA H A+++ E +  K+ ++  +ITQN+D LHR+AG++N++ IHG +F+T+C  C  V EN+ SPIC  L  KG P   T+++SIP E LP CE   C GLLRP+VVWFGENL P  LE+    +  CDLC+V+GTS +V P A F  QV  RGVPVAEFN E+T  + + ++  +GP  +TLP  L
Sbjct:   39 SMADFRKCFAKAKHIVIISGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGIVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDKELGRCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEAL 301
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A1Y1KIE8 (NAD-dependent protein deacylase OS=Photinus pyralis OX=7054 GN=PPYR_03237 PE=3 SV=1)

HSP 1 Score: 289.271 bits (739), Expect = 2.680e-91
Identity = 137/259 (52.90%), Postives = 176/259 (67.95%), Query Frame = 1 
Query:   43 IEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            ++F+  L  +KNI ++TGAG+SA+SGI TFRG   + WR + + +LAT  AF  NPSLVWEFY +RR +   A PN AH AL+KFE +C +EN+QFTL+TQNVDGLH +AGS+N++ IHG I +  C KCK V EN   PICE LR +GDPN    S+IP   LP C+ C  L+RP VVWFGENL  D L+K    ++ CDL +V+GTS +V P ASF   V +RG PVAEFN+E    S   Q++  GP  +TLP  L
Sbjct:    7 LDFRNLLSESKNIAILTGAGVSAESGIGTFRGPSGM-WRTHNAVDLATPTAFASNPSLVWEFYQWRRSVAFNAKPNDAHLALAKFEERCNRENRQFTLLTQNVDGLHIKAGSKNVLEIHGSIRKVVCTKCKFVDENLDQPICEALRGRGDPNGGNQSAIPVGELPKCKRCSSLVRPFVVWFGENLDRDVLKKCRKVVETCDLFLVVGTSSVVYPAASFAPFVADRGKPVAEFNIEDEPASSTFQFYFAGPCGTTLPAAL 264
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: V3ZQA2 (NAD-dependent protein deacylase OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_207074 PE=3 SV=1)

HSP 1 Score: 287.73 bits (735), Expect = 2.013e-90
Identity = 133/257 (51.75%), Postives = 183/257 (71.21%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLP 810
            F++    AK+I+V+TGAG+SA+SG+PTFRG+    WR +++  LA+  AF +NPSLVWEFYH+RRE+    +PN AH A+++ E + K +N++  ++TQN+DGLH+RAGSE+II +HG +F+T+C+KC  +  N  SPICE LR KG P     +  IPE+ LP C+   C GLLRP VVWFGENL P  L+KS+  ++NCDLC+V+GTS +V P A F  QV +RGV VAEFN+E T  +G  +Y  +GPA   LP
Sbjct:   31 FREEFSKAKHIVVLTGAGVSAESGVPTFRGAGGY-WRKWQAQQLASPEAFTDNPSLVWEFYHYRREVMASKHPNPAHIAIAECEKRLKSQNRRVVIVTQNIDGLHKRAGSEDIIELHGNLFKTRCLKCGEIAVNNDSPICEALRGKGAPEPDAPDGKIPEDQLPRCKKTDCSGLLRPQVVWFGENLDPKVLDKSFSELENCDLCLVVGTSSVVYPAAMFAPQVASRGVTVAEFNIEDTVSTGVFKYHFQGPAGENLP 286
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A5N5LC88 (Uncharacterized protein OS=Pangasianodon hypophthalmus OX=310915 GN=PHYPO_G00092990 PE=4 SV=1)

HSP 1 Score: 288.5 bits (737), Expect = 5.159e-90
Identity = 136/260 (52.31%), Postives = 180/260 (69.23%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            F++    AK+I +ITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  +PSLVWEFYH+RRE+     PN AH A+++ E +  ++ +   +ITQN+D LHRRAGS N++ IHG +F+T+CM C  VKEN+ SPIC  L  KG P+   +++ IP+E LP CE   CRGLLRP+VVWFGE+L PD L ++   +K CDLC+V+GTS IV P A F  QV  RGVPVAEFN+E T  +    Y   GP  STLPP L
Sbjct:   78 FRKDFAKAKHIAIITGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPQAFSRDPSLVWEFYHYRREVMSSKQPNPAHLAIAECEARLSQQGRSVVVITQNIDELHRRAGSRNVLEIHGSLFKTRCMSCGEVKENYKSPICSALEGKGAPDPKAKDARIPKEDLPRCEAKRCRGLLRPHVVWFGESLDPDILTRADQELKRCDLCLVVGTSSIVYPAAMFAPQVAARGVPVAEFNMECTPATTCFMYHFDGPCGSTLPPAL 336
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A212F1S9 (NAD-dependent protein deacylase OS=Danaus plexippus plexippus OX=278856 GN=KGM_208880 PE=3 SV=1)

HSP 1 Score: 285.419 bits (729), Expect = 1.003e-89
Identity = 138/261 (52.87%), Postives = 183/261 (70.11%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTE-NSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +FK+ LK AK I++++GAGISA+SGIPTFRG+    WR Y++ +LA+  AF  NPSLVWEFYH+RRE+  KA PNA H A++ FE K    +K+ T+ITQNVDGLH RAG++++I +HG +F+T+C KCK V  N  +PICE L ++G P+ST   S IP +SLP C+   C GLLRP++VWFGE+L PD L K+  A+  CDLC+V+GTS +V P A F  Q   RG  VAEFN+E T  + +  Y+  GP   TLP  L
Sbjct:   11 KFKECLKTAKEIVILSGAGISAESGIPTFRGAGGY-WRKYQAASLASPEAFRNNPSLVWEFYHYRREVAAKAEPNAGHKAVANFEAK-TSSSKKVTVITQNVDGLHARAGTKSLIELHGNLFKTRCTKCKEVLVNTDTPICEALTNRGAPDSTVVGSDIPIKSLPHCKKGTCGGLLRPHIVWFGESLDPDVLNKAEAAMSTCDLCLVVGTSSVVYPAAMFAPQAAQRGAIVAEFNLEPTPTTSEFHYYFEGPCGKTLPVAL 269
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A1B6F0Z9 (NAD-dependent protein deacylase OS=Cuerna arida OX=1464854 GN=g.27945 PE=3 SV=1)

HSP 1 Score: 284.648 bits (727), Expect = 1.945e-89
Identity = 137/262 (52.29%), Postives = 185/262 (70.61%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKEN--KQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTEN-SSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            FK+ L +A+ I+VI+GAGISA+SG+PTFRG+  L WR Y++  LAT  AF ++PSLVWEFYH+RRE+ L   PN AH ++++FE + + E   ++ TL+TQNVDGLH  AGS N+  IHG +F+TKC+ C  V  N  SPICE LR +G P+  ++   IP E LP C+   C GLLRP +VWFGENLH D L+K+ +AI+ CDLC+V+GTS +V P A +   + +RGVPVAEFNVE T+ +   Q+  +GP S T+P  L
Sbjct:   14 FKEVLSMAQRIVVISGAGISAESGVPTFRGAGGL-WRKYQAQRLATPEAFKQSPSLVWEFYHYRRELVLTKKPNQAHLSIAEFEKQLEHEGQGRRLTLLTQNVDGLHLAAGSHNVAEIHGSLFKTKCLSCGEVTVNRDSPICEALRGRGAPDLDKDLPEIPLEHLPRCKKSGCNGLLRPYIVWFGENLHEDALDKATEAIEECDLCLVVGTSSVVYPAAMWAPGLASRGVPVAEFNVEHTEATHHFQFHFQGPCSQTIPAAL 274
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BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:103031700])

HSP 1 Score: 268.855 bits (686), Expect = 2.894e-86
Identity = 129/261 (49.43%), Postives = 171/261 (65.52%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +ITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  +PSLVWEFYH+RRE+     PNAAH ++++ E +  ++ +   +ITQN+D LH RAGS NI+ +HG +F+T+CM C  VK N  SPIC  L  KG P+   + + IP   LP CE   C GLLRP VVWFGE L  D L    + ++ CDLC+V+GTS IV P A F  QV  RGVPVAEFN EST  + +  Y   GP  + LPP L
Sbjct:   37 QFRKDFAKAKHIAIITGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPGAFSRDPSLVWEFYHYRREVMSSKEPNAAHMSIAECEARLSQQGRSVVVITQNIDELHYRAGSRNILELHGSLFKTRCMSCGEVKANHTSPICPALEGKGAPDPEAKEARIPVNDLPRCERRGCHGLLRPYVVWFGEALDSDILSSVEEELEKCDLCLVVGTSSIVYPAAMFAPQVAARGVPVAEFNTESTPATMRFMYHFEGPCGTILPPAL 296
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BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: ENSAMXT00000052214.1 (NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [Source:NCBI gene;Acc:111194338])

HSP 1 Score: 259.225 bits (661), Expect = 1.457e-82
Identity = 122/262 (46.56%), Postives = 176/262 (67.18%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 822
            EF++    AK+I +ITGAG+SA+SG+PTFR +    WR +++ +LAT  AF  NPS VWEFYH+ RE+ LKA P+ AH A+++ E +  K+ +   +ITQNVD LHRRAGS++++ +HG +F T+C+ C +V  +  SPIC  L  KGDP+ +  +++IP ++LP C+   C GLLRP+V+WFGE L    L K    +  CDLC+++GT+ +V P A F  QV +RGVPVAEFN+       +  Y  +GP ++TLP  LE
Sbjct:   39 EFREVFSKAKHIAIITGAGVSAESGLPTFRAASG-HWRKWKTQDLATAQAFSRNPSRVWEFYHYWRELALKATPSEAHRAIAECEARLSKQGRSVVVITQNVDELHRRAGSKHVLEVHGSLFRTRCLSCGDVDASHHSPICPALEGKGDPDPNCRDAAIPVKNLPRCDEGGCDGLLRPHVIWFGETLDSHILTKVEKELDACDLCLLVGTASVVFPAAMFAPQVASRGVPVAEFNIRPRANMSRFTYHFQGPCATTLPVALE 299
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BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: ENSAMXT00000009390.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [Source:NCBI gene;Acc:111194338])

HSP 1 Score: 255.373 bits (651), Expect = 3.408e-81
Identity = 126/281 (44.84%), Postives = 182/281 (64.77%), Query Frame = 1 
Query:    4 YINLIWFEI-----YMSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 822
            +   +WF       YM+  EF++    AK+I +ITGAG+SA+SG+PTFR +    WR +++ +LAT  AF  NPS VWEFYH+ RE+ LKA P+ AH A+++ E +  K+ +   +ITQNVD LHRRAGS++++ +HG +F T+C+ C +V  +  SPIC  L  KGDP+ +  +++IP ++LP C+   C GLLRP+V+WFGE L    L K    +  CDLC+++GT+ +V P A F  QV +RGVPVAEFN+          Y  +GP ++TLP  LE
Sbjct:   15 FFTGLWFTKACLTRYMA--EFREVFSKAKHIAIITGAGVSAESGLPTFRAASG-HWRKWKTQDLATAQAFSRNPSRVWEFYHYWRELALKATPSEAHRAIAECEARLSKQGRSVVVITQNVDELHRRAGSKHVLEVHGSLFRTRCLSCGDVDASHHSPICPALEGKGDPDPNCRDAAIPVKNLPRCDEGGCDGLLRPHVIWFGETLDSHILTKVEKELDACDLCLLVGTASVVFPAAMFAPQVASRGVPVAEFNIRPR----ANMYHFQGPCATTLPVALE 288
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:103031700])

HSP 1 Score: 252.677 bits (644), Expect = 2.745e-80
Identity = 124/260 (47.69%), Postives = 163/260 (62.69%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +ITGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  +PSLVWEFYH+RRE+     PNAAH ++++ E +  ++ +   +ITQN+D LH RAGS NI+ +HG +F+T+CM C  VK N  SPIC  L  KG                 CE   C GLLRP VVWFGE L  D L    + ++ CDLC+V+GTS IV P A F  QV  RGVPVAEFN EST  + +  Y   GP  + LPP L
Sbjct:   37 QFRKDFAKAKHIAIITGAGVSAESGVPTFRGAGGY-WRKWQAQDLATPGAFSRDPSLVWEFYHYRREVMSSKEPNAAHMSIAECEARLSQQGRSVVVITQNIDELHYRAGSRNILELHGSLFKTRCMSCGEVKANHTSPICPALEGKG-----------------CERRGCHGLLRPYVVWFGEALDSDILSSVEEELEKCDLCLVVGTSSIVYPAAMFAPQVAARGVPVAEFNTESTPATMRFMYHFEGPCGTILPPAL 278
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:103031700])

HSP 1 Score: 249.98 bits (637), Expect = 1.418e-78
Identity = 130/297 (43.77%), Postives = 172/297 (57.91%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYES--------------------------C----------NLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            +F++    AK+I +ITGAG+SA+SG+PTFRG+    WR +++                          C          +LAT  AF  +PSLVWEFYH+RRE+     PNAAH ++++ E +  ++ +   +ITQN+D LH RAGS NI+ +HG +F+T+CM C  VK N  SPIC  L  KG P+   + + IP   LP CE   C GLLRP VVWFGE L  D L    + ++ CDLC+V+GTS IV P A F  QV  RGVPVAEFN EST  + +  Y   GP  + LPP L
Sbjct:   37 QFRKDFAKAKHIAIITGAGVSAESGVPTFRGAGGY-WRKWQAQVTHMINVIHFFPLLFAVFLLLCYFPCKQPYLSISLQDLATPGAFSRDPSLVWEFYHYRREVMSSKEPNAAHMSIAECEARLSQQGRSVVVITQNIDELHYRAGSRNILELHGSLFKTRCMSCGEVKANHTSPICPALEGKGAPDPEAKEARIPVNDLPRCERRGCHGLLRPYVVWFGEALDSDILSSVEEELEKCDLCLVVGTSSIVYPAAMFAPQVAARGVPVAEFNTESTPATMRFMYHFEGPCGTILPPAL 332
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 93.2041 bits (230), Expect = 2.765e-21
Identity = 72/280 (25.71%), Postives = 123/280 (43.93%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGS----------RALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENF--------ISPICEGLRDKG-DPNST---ENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            + +  L  ++ + V+ GAG+S +SGIP +R            R ++   +    +A    +  N +  W  +  RR       PNAAH AL ++E    ++ +   L+TQNVD LH +AGS  I  +HG      C+ CK V +          ++P  +   ++   P+      +S +    +P C  C G L+P V +FG+N+   T++  Y  +++ D  +V G+S  V     F        +P+A  N+  T      Q  +       LP +L
Sbjct:   42 QLQDFLANSRRLFVLAGAGLSTESGIPDYRSEGVGLYARTSRRPMQHAEFARSAVARRRYWARNFT-GWPRFSSRR-------PNAAHLALGRWE----QQGRLHWLVTQNVDALHAKAGSRRITELHGCSHRVVCLDCKEVTQRTELQQRMLDMNPGWQQQHEQAIAPDGDVLLSDSQVESFRVPPCRSCGGPLKPEVTFFGDNVDRRTVDDVYQRLES-DTVLVAGSSLQVYSGYRFIRAAYEEKIPIAILNIGPTRADALAQLKVSSRCGDILPLML 308
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt2 (sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) [Source:NCBI gene;Acc:322309])

HSP 1 Score: 87.4261 bits (215), Expect = 5.250e-19
Identity = 66/221 (29.86%), Postives = 103/221 (46.61%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPA------FLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENK-QFTLITQNVDGLHRRAGSEN--IISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQV 708
            KNI+ + GAGIS  +GIP FR      + N +  NL    A      F ENP     F+   +E+     P      +S + ++  K+ +      TQN+D L R AG EN  ++  HG    + C+ C++  E  +S + E               I  + +P CE C+ +++P++V+FGE L              CDL +++GTS +VQP AS   +V
Sbjct:   42 KNIVCMVGAGISTAAGIPDFRSPGTGLYDNLQKYNLPHPQAVFDIGYFRENPE---PFFALAKEL----YPGQFKPTVSHYFIRLLKDKECLLRCYTQNIDTLERVAGLENNELVEAHGTFHTSHCLGCRH--EYCLSWMKE--------------QIFSDKVPRCEKCKSVVKPDIVFFGEALPEKFFTCVQSDFPKCDLLIIMGTSLVVQPFASLTSRV 239
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 79.337 bits (194), Expect = 1.001e-16
Identity = 71/253 (28.06%), Postives = 103/253 (40.71%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLA------TLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASST 804
            KNI+++ GAG+S  SGIP FR      + N +  +L        L  F  +P     F+   +E+      PN AH     F     +      L TQN+DGL R AG   + ++  HG      C +C+                K  P      ++    +P C  C  +++P++V+FGE+L P             DL +VIGTS  V P A      +  GVP    N E+      V  F R  +S T
Sbjct:   27 KNIVLMAGAGMSTASGIPDFRTPGTGLYDNLQRYHLPFPEAVFDLDFFAVDPK---PFFTLAQELYPGNCRPNDAH----YFARLLHERRLLLRLYTQNIDGLERVAGLPPDMLVEAHGTFASATCTQCR----------------KPQPGDQVRRTVMSGKIPHCGACSAVVKPDIVFFGEDL-PRRFYAYDQDFSMADLLIVIGTSLEVMPFAGL-VSAVRPGVPRLLLNREA------VGLFRRAASSPT 248
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt6 (sirtuin 6 [Source:ZFIN;Acc:ZDB-GENE-031007-2])

HSP 1 Score: 74.7146 bits (182), Expect = 4.409e-15
Identity = 67/279 (24.01%), Postives = 121/279 (43.37%), Query Frame = 1 
Query:   25 EIYMSQIEFKQTLKLAKNILVITGAGISADSGIPTF--RGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKC--KNVKEN--------FISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            E+    +E    ++ +K +++ TGAG+S  +GIP F  RG   + W   E   L   P F    ++ +E           A P A H A+    +   +E     L++QNVDGLH R+G   + +  +HG +F  +C +C  + V+++        +   IC+ ++ +G                    CRG L+  ++ + ++L    L  +  A +N DL + +GT+  ++P  S P      G  +   N++ T +  Q    I G     +  L+
Sbjct:   29 EVDRKVLELADLVRASKYMVIHTGAGVSTAAGIPDFSYRGPNGV-W-TMEQKGLT--PKF----NITFE----------DARPTATHMAM----LGLYREGLLKHLVSQNVDGLHIRSGFPRDKLSELHGNMFIEECERCGKQYVRDHTVGTMGLKYTGKICDVVKARG-----------------LRGCRGKLKDTILDWEDSLPERDLTLAEKACRNADLTITLGTTLQIKPSGSLPLLTKRNGGKLVIVNLQPTQLDKQADLRIYGYVDDVVTKLM 268
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST1 (NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication [Source:SGD;Acc:S000005429])

HSP 1 Score: 86.2705 bits (212), Expect = 1.668e-18
Identity = 79/265 (29.81%), Postives = 119/265 (44.91%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRA----LRWRNYES-CNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKC------KNVKENF------ISPICEGLRDKGDPNSTENSSIPEE---SLPTCEFCRGLLRPNVVWFGENLHPDTLEKSY-DAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRG-VPVAEFNV 744
             F  TL+ AK ILV+TGAG+S   GIP FR S      +R    E   ++  L  FL++PS+ +   H      +   P   ++ L  F    + + K     TQN+D L   AG   + ++  HG      C+ C      + + EN       + P C   R +  P S  N+++      + P  +   G+L+P++ +FGE L P    K+    I  CDL + IGTS  V PV+          P  +INR  V  AEF++
Sbjct:  192 HFTATLRNAKKILVLTGAGVSTSLGIPDFRSSEGFYSKIRHLGLEDPQDVFNLDIFLQDPSVFYNIAH------MVLPPENMYSPLHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNINFNSPILK-SYGVLKPDMTFFGEAL-PSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQILINRDMVTHAEFDL 448
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: SIR2 (Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200])

HSP 1 Score: 80.4925 bits (197), Expect = 1.361e-16
Identity = 77/271 (28.41%), Postives = 116/271 (42.80%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNY-----ESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENIISIHGEIFETKCMKCK---------NVKENFISPIC------------EGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSY-DAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRG-VPVAEFNV 744
             F Q L  A+ ILV+TGAG+S   GIP FR S     +       +  ++     F+ +PS+   FY+    +     P   ++ L  F    + + K     TQN+D L   AG  ++ ++  HG      C+ C          N   N   P+C            EG  +K    +++ S    E  P      G+L+P++ +FGE L P+   KS  + I  CDL + IGTS  V PV+          P  +INR  V  AEF++
Sbjct:  246 HFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNIFMHDPSV---FYNIANMVL---PPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAASQGSM--SERPPYILNSYGVLKPDITFFGEAL-PNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPSHVPQVLINRDPVKHAEFDL 507
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST2 (Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export [Source:SGD;Acc:S000005936])

HSP 1 Score: 66.2402 bits (160), Expect = 2.990e-12
Identity = 64/234 (27.35%), Postives = 99/234 (42.31%), Query Frame = 1 
Query:   79 ILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPA-----FLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSEN--IISIHGEIFETKCMKCKNV--KENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSY--------DAIKNCD------LCVVIGTSGIVQPVASFPYQV 708
            ++ + GAGIS   GIP FR      + N     L    A     F ++  L   FY   +E+      P+  H  L  F+ K    +    + TQN+D L R+AG ++  II  HG      C+ C  V   + F S + E                P +    C+ C  L++P +V+FGE+L PD+  +++        + I          L +V+GTS  V P AS P ++
Sbjct:   27 VIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPL--PFYTLAKELYPGNFRPSKFHYLLKLFQDK----DVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQVFKSKLAEH---------------PIKDFVKCDVCGELVKPAIVFFGEDL-PDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEI 238
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST3 (Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000005551])

HSP 1 Score: 63.929 bits (154), Expect = 2.254e-11
Identity = 72/276 (26.09%), Postives = 108/276 (39.13%), Query Frame = 1 
Query:   55 QTLKLAKNILVITGAGISADSGIPTFRGSRAL----------RWRNYESCNLATLPAFLEN--PSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG------------------SENIISIHGEIFETKCMKCKNV-------------KENFISPICEGLRDK--GDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPD----TLEKSYDAIK-NCDLCVVIGTS----GIVQPVASFPYQVINRG 720
            + L  ++ I  +TGAGIS ++GIP FR S  L           W       +  +  F ++   S+  +F          A P   H    KF    K  NK     TQN+DGL    G                  + +++ +HG++    C KC                 E  + P CE L +K   +   T  S++            G+LRPN+V +GEN HP     T   + D IK N D  +++GTS    G+ Q V     ++ +RG
Sbjct:   47 KQLSRSRRIACLTGAGISCNAGIPDFRSSDGLYDLVKKDCSQYWSIKSGREMFDISLFRDDFKISIFAKFMERLYSNVQLAKPTKTH----KFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCLRRGELPLCPDCEALINKRLNEGKRTLGSNV------------GILRPNIVLYGEN-HPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKKLSKKIHDRG 305
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST4 (NAD(+)-dependent protein deacetylase; deacetylation targets are primarily mitochondrial proteins; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism; accumulates in mitochondria in response to biotin starvation and may link biotin metabolism with energy homeostasis; member of the Sir2 family and may be the functional equivalent of human SIRT3 [Source:SGD;Acc:S000002599])

HSP 1 Score: 56.225 bits (134), Expect = 4.291e-9
Identity = 70/261 (26.82%), Postives = 111/261 (42.53%), Query Frame = 1 
Query:   58 TLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLE------NPSLVWEFYH-----FRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAG--SENI---------ISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPE-ESLPTCEFCRGL-------LRPNVVWFGENLHP--DTLEK--SYDAIKNCDLCVVIGTS----GIVQPVASFPYQV-INRGV 723
             L  +K ++V++GAGIS  +GIP FR S  +    + + N  +     +      + S+  +F       FR  +     P   H  L++F     ++ +   L TQN+DGL  +    S N+         + +HG I   +C KC N+K     P      DK D  +    S P+ E   T     GL       LRP V+ + E +HP  D + +  + D  K  D  +++GTS    G+      F  +V  NRG+
Sbjct:   88 ALNYSKRMVVVSGAGISVAAGIPDFRSSEGI----FSTVNGGSGKDLFDYNRVYGDESMSLKFNQLMVSLFR--LSKNCQPTKFHEMLNEFA----RDGRLLRLYTQNIDGLDTQLPHLSTNVPLAKPIPSTVQLHGSIKHMECNKCLNIKP--FDPELFKCDDKFDSRTEIIPSCPQCEEYETVRKMAGLRSTGVGKLRPRVILYNE-VHPEGDFIGEIANNDLKKRIDCLIIVGTSLKIPGVKNICRQFAAKVHANRGI 335
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO47362 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMK8])

HSP 1 Score: 241.121 bits (614), Expect = 1.825e-76
Identity = 121/262 (46.18%), Postives = 165/262 (62.98%), Query Frame = 1 
Query:   40 QIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTC--EFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            + + K  L  AKNIL +TGAGISA+SGIPTFRG+  L WR + + +LAT  AF  NPSLVWEFY +RRE+ L   PN AH A+++F+ K + E KQ  ++TQN+D LH+ AG+E++I +HG +F+T+C             I  G+    DPN+  ++ IP   LP C    C  L+RP+VVWFGE L P  L++    +  CD C ++GTS +V P A F   +  RGVPVAEFN+E T  +GQ  +  +G A  TLPP+L
Sbjct:   15 KTKLKDLLSKAKNILFLTGAGISAESGIPTFRGAGGL-WRTFSATDLATPGAFHTNPSLVWEFYSYRREVVLSKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGAEDVIELHGTLFKTRCNHVTTQGS-----ITLGIVLAPDPNA-PDAKIPLTELPRCVRPECDALVRPHVVWFGEALDPVVLQQIEKVLGECDFCFIVGTSSVVYPAAGFAPMLAQRGVPVAEFNMEETSCTGQFSFHFQGKAGVTLPPIL 269
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO35866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK95])

HSP 1 Score: 98.9821 bits (245), Expect = 5.766e-23
Identity = 73/269 (27.14%), Postives = 121/269 (44.98%), Query Frame = 1 
Query:   76 NILVITGAGISADSGIPTFRG----------SRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNV------KENFIS------PICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPL 816
             I VITGAGIS +SGI  +R            R + ++ +    +     +  N  + W  +  R+       PN AH AL+K E          +L+TQNVD LH +AGS+N+I +HG      C+ C  +      ++  I        + +G    GD   T + ++ +  +P C+ C G+L+P VV+FG+++    +  +YD +   D   +IG++  V     F  +   +G P+A  N+  T         + G   + LP L
Sbjct:   62 KIFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARN-YVGWPEFGSRQ-------PNEAHYALAKLETL----GSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVICLGCNQITARTALQKRMIEFNPDWHAVGQGQAPDGDTFLT-SEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILNIGKTRADKLASLKVSGVCGTVLPKL 317
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO46813 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNW2])

HSP 1 Score: 87.8113 bits (216), Expect = 3.312e-19
Identity = 66/222 (29.73%), Postives = 105/222 (47.30%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRRE------ICLKANPNAAHAALSKFEMKCKKENKQFTL-ITQNVDGLHRRAGSEN--IISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVI 711
            K+I+V+TGAGIS  +GIP FR      + N +  NL         P  ++E  +FR        +C +  P +    +S + +K   + K      TQNVD L R AG  +  ++  HG      C++CK           E +RD+          I  + +P C  C G+++P++V+FGE+L           + +CDL +++GTS  VQP AS   +V+
Sbjct:   43 KHIIVMTGAGISTAAGIPDFRSPGTGLYDNLQKYNLPY-------PESIFEIGYFRSNPEPFFALCKELYPGSFKPTMSHYFIKLLYDKKLLLRNYTQNVDTLERIAGVPDDLLVEAHGSFHTAHCIECKKEYTK------EDVRDE----------IFADKVPRCSGCEGVIKPDIVFFGESLPGRFHRLVPQDMPHCDLIIIMGTSLAVQPFASLIDRVL 241
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO31684 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX90])

HSP 1 Score: 83.5741 bits (205), Expect = 8.820e-18
Identity = 65/232 (28.02%), Postives = 107/232 (46.12%), Query Frame = 1 
Query:   55 QTLKLAKNILVITGAGISADSGIPTFRGSRALRWR-NYESCNLATLPA------FLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCR------GLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQV 708
            + +K  KNI+V+TGAG+S   GIP FR    +  + + E  +L    A      F +NP     F+ F +EI   +  P+  H    +F  + ++        +QN+D L + AG   +I  HG      CM+CK+         CE +++           I  +++P C  C        +++P++V+FGE+L  +      D     DL +VIG+S  V+PVA  P  +
Sbjct:   64 RLIKKCKNIIVLTGAGVSVSCGIPDFRSRDGIYAKLSVEYPDLPDPQAMFDITYFNQNPK---PFFKFAKEIYPGQFKPSLCH----RFIHQLEEHGHLLRNYSQNIDTLEQVAGITRVIQCHGSFSTASCMRCKHKVP------CEAIKE----------DIFRKNIPVCSTCSPDEEFPSIMKPDIVFFGESLPSNFYTHLGDDSNKADLLIVIGSSLKVRPVALIPSHI 272
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO48459 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIU3])

HSP 1 Score: 82.4185 bits (202), Expect = 1.491e-17
Identity = 67/234 (28.63%), Postives = 106/234 (45.30%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLE------NPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTL--ITQNVDGLHRRAG--SENIISIHGEIFETKCMKC-KNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF--------PYQVINR 717
            KNI+V+TGAGIS  +GIP FR   +  +   ++  L T  +  E      NP     F+   + +     P      +S + +K   +NK   L   TQN+D L R AG   ++++  HG      CM C K   +++I                    I  + +P C  C G+++P++ +FG+ +     + + +    CDL +V+GTS IVQP AS         P  +INR
Sbjct:   19 KNIVVLTGAGISTTAGIPDFRTPGSGLFNVLQTYGLTTARSIFEIDYFQMNPK---PFFVAAKAV----YPGQFKPTISHYFIKLL-QNKGLLLRHYTQNIDTLERVAGITGDHLMEAHGSFHTGHCMACNKEYSQDWI-----------------RVEIMADKIPRCTECDGVVKPDIGFFGDPMPDKFYQLAAEDFPKCDLLIVMGTSLIVQPFASLIARVSVDTPRLLINR 227
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:101162440])

HSP 1 Score: 282.337 bits (721), Expect = 1.641e-91
Identity = 132/260 (50.77%), Postives = 185/260 (71.15%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCEF--CRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            F+     A+NI ++TGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+ L  +PNAAH A+++ E +  K+ ++ T+ITQN+D LHRRAGS+NI+ IHG +F+T+C+ C + + N  SPIC  L+DKG P+ +T ++ IP E LP CE   C GLLRP VVWFGE+L  D L +S++ + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN+E+T  +   ++  +GP  +TLP  L
Sbjct:   39 FRDFFAKAENIAILTGAGVSAESGVPTFRGAGGF-WRKWQAQDLATPEAFSGNPSRVWEFYHYRREVMLTKDPNAAHKAIAECEERLGKQGRKVTVITQNIDELHRRAGSKNILEIHGSLFKTRCLSCGHEEANHKSPICPALKDKGAPDPNTHDAQIPVEQLPRCERAGCGGLLRPAVVWFGESLDADVLSRSHEVLDSCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTHFKFHFQGPCGTTLPAAL 297
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:101162440])

HSP 1 Score: 268.855 bits (686), Expect = 6.414e-86
Identity = 126/246 (51.22%), Postives = 177/246 (71.95%), Query Frame = 1 
Query:   49 FKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQY 777
            F+     A+NI ++TGAG+SA+SG+PTFRG+    WR +++ +LAT  AF  NPS VWEFYH+RRE+ L  +PNAAH A+++ E +  K+ ++ T+ITQN+D LHRRAGS+NI+ IHG +F+T+C+ C + + N  SPIC  L+DKG P+ +T ++ IP E LP CE   C GLLRP VVWFGE+L  D L +S++ + +CDLC+V+GTS +V P A F  QV  RGVPVAEFN+E+T  +   ++
Sbjct:   39 FRDFFAKAENIAILTGAGVSAESGVPTFRGAGGF-WRKWQAQDLATPEAFSGNPSRVWEFYHYRREVMLTKDPNAAHKAIAECEERLGKQGRKVTVITQNIDELHRRAGSKNILEIHGSLFKTRCLSCGHEEANHKSPICPALKDKGAPDPNTHDAQIPVEQLPRCERAGCGGLLRPAVVWFGESLDADVLSRSHEVLDSCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTHFKH 283
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: ENSORLT00000021505.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial [Source:NCBI gene;Acc:101163111])

HSP 1 Score: 257.684 bits (657), Expect = 5.148e-82
Identity = 127/261 (48.66%), Postives = 171/261 (65.52%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLL 819
            EF+     AK+I +ITGAG+SA+SG+PTFRG    +WR + S +LAT  AF  NPS VWEFYH+RRE+ L   P+A H A+++ E + KK+ +   +ITQ +D LHR+AGS++++ +HG + ET+CM C  V  N  SPIC  L+ KG P  +  ++ IP + LP CE   C GLLRPNVV+FGE L    L K    I+ CDLC+V+GTS IV P A F  +V +RGVPVAEFN+ +T  +    Y  +GP  +TLP  L
Sbjct:   37 EFRSVFSKAKHIAIITGAGVSAESGVPTFRGEHE-KWRKWVSQDLATPEAFSRNPSRVWEFYHYRRELVLDKKPSAVHVAIAECEARLKKQGRTVVVITQCIDDLHRQAGSKHVLKVHGSLMETRCMSCGQVTVNKRSPICAALKGKGAPGLNVADAQIPVDKLPRCEERDCHGLLRPNVVFFGETLDSHILTKVEKEIEICDLCLVVGTSSIVYPAAMFGPRVASRGVPVAEFNMSTTPKTEYFTYHFQGPCGTTLPLAL 296
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: ENSORLT00000021506.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial [Source:NCBI gene;Acc:101163111])

HSP 1 Score: 257.299 bits (656), Expect = 7.338e-82
Identity = 126/258 (48.84%), Postives = 170/258 (65.89%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPN-STENSSIPEESLPTCE--FCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLP 810
            EF+     AK+I +ITGAG+SA+SG+PTFRG    +WR + S +LAT  AF  NPS VWEFYH+RRE+ L   P+A H A+++ E + KK+ +   +ITQ +D LHR+AGS++++ +HG + ET+CM C  V  N  SPIC  L+ KG P  +  ++ IP + LP CE   C GLLRPNVV+FGE L    L K    I+ CDLC+V+GTS IV P A F  +V +RGVPVAEFN+ +T  +    Y  +GP  +TLP
Sbjct:   37 EFRSVFSKAKHIAIITGAGVSAESGVPTFRGEHE-KWRKWVSQDLATPEAFSRNPSRVWEFYHYRRELVLDKKPSAVHVAIAECEARLKKQGRTVVVITQCIDDLHRQAGSKHVLKVHGSLMETRCMSCGQVTVNKRSPICAALKGKGAPGLNVADAQIPVDKLPRCEERDCHGLLRPNVVFFGETLDSHILTKVEKEIEICDLCLVVGTSSIVYPAAMFGPRVASRGVPVAEFNMSTTPKTEYFTYHFQGPCGTTLP 293
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt4 (sirtuin 4 [Source:NCBI gene;Acc:101156953])

HSP 1 Score: 91.6633 bits (226), Expect = 4.931e-20
Identity = 72/259 (27.80%), Postives = 112/259 (43.24%), Query Frame = 1 
Query:   70 AKNILVITGAGISADSGIPTFRGS-------------------RALRWRN-YESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNV--KENF------ISPICEGLRDKGDPNST---ENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVEST 753
            A+ +LVITGAG+S +SGIP +R                     R+ R R  Y + N    P F  +                   PN AH AL ++E    +  K   L+TQNVD LH +AG + +  +HG      C+ C  V  +E+       I+P          P+     E+  +    +P+C+ C G+L+P V +FG+ +   T+E  +  +   D  +V+G+S  V     F     +R +PVA  N+  T
Sbjct:   51 ARRMLVITGAGLSTESGIPDYRSEGVGLYARTDRRPMQHAEFVRSARSRQRYWARNFLGWPQFSSH------------------QPNLAHRALRRWE----EGGKLHWLVTQNVDALHGKAGQKRLTELHGCAHRVVCLSCSAVTPREDLQGRFVAINPEWSAQAGAVAPDGDVFLEDEQVLNFRVPSCQNCGGILKPEVTFFGDTVSKTTVEFVHGRLAESDSVLVVGSSLQVYSGYRFLLAASDRKLPVAILNIGPT 287
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000027361.1 (SMESG000027361.1)

HSP 1 Score: 545.043 bits (1403), Expect = 0.000e+0
Identity = 263/263 (100.00%), Postives = 263/263 (100.00%), Query Frame = 1 
Query:   34 MSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 822
            MSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE
Sbjct:    1 MSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 263
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000074693.1 (SMESG000074693.1)

HSP 1 Score: 95.1301 bits (235), Expect = 1.328e-21
Identity = 74/275 (26.91%), Postives = 127/275 (46.18%), Query Frame = 1 
Query:   46 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFL---ENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKC-----KNVKENFISPICEGLRDKGDPN--STENSSIPEESL------PTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 822
            +F + +     +LV+TGAG+S +SGIP +R S+ +     ++        FL   EN    W   +F   +     PN AH  + K+E    KE+K F  ++QNVD LH+++G + ++ +HG   +  C+ C     ++  +   + +    R + D N  + +   I E+ L      P C  C+G+L+P++++FG+N+   T E     I   D  + +GTS  V        Q     +P+   N+  T       Y ++G     LP L E
Sbjct:   17 DFAKFISSRGKLLVVTGAGVSTESGIPDYR-SKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLVELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDE 286
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 92.8189 bits (229), Expect = 8.964e-20
Identity = 78/243 (32.10%), Postives = 114/243 (46.91%), Query Frame = 1 
Query:   49 FKQT---LKLAKNILVITGAGISADSGIPTFRGSRALRWRNY-------ESCNLATLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCK-NVKENFIS--------PICEGLRDKGDPN------STENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFP 699
            FKQ    ++++KNI+V+TGAGIS   G+P FR    +  R         E  ++  +  F +NP     F+ F +EI   K  P+  H  +   E K     K     +QN+D L + AG +NII  HG      CM+C+  VK  FI         PIC     + + N      S  NS   + ++P       +++P+VV+FGE L  D   K  +     DL +VIG+S  V+PVA  P
Sbjct:   87 FKQACDLIRVSKNIMVLTGAGISVPCGVPDFRSRNGIYARLAVDFPDLDEPQSMFDIHYFSKNPK---PFFKFAKEIYPGKFTPSFGHRFIKVLEDK----GKLLRNYSQNIDTLEQIAGIKNIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERNQENLLSSIGNSDEVDTNIP-------IMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKVRPVAHIP 315
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 92.8189 bits (229), Expect = 9.334e-20
Identity = 78/243 (32.10%), Postives = 114/243 (46.91%), Query Frame = 1 
Query:   49 FKQT---LKLAKNILVITGAGISADSGIPTFRGSRALRWRNY-------ESCNLATLPAFLENPSLVWEFYHFRREICL-KANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCK-NVKENFIS--------PICEGLRDKGDPN------STENSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFP 699
            FKQ    ++++KNI+V+TGAGIS   G+P FR    +  R         E  ++  +  F +NP     F+ F +EI   K  P+  H  +   E K     K     +QN+D L + AG +NII  HG      CM+C+  VK  FI         PIC     + + N      S  NS   + ++P       +++P+VV+FGE L  D   K  +     DL +VIG+S  V+PVA  P
Sbjct:   96 FKQACDLIRVSKNIMVLTGAGISVPCGVPDFRSRNGIYARLAVDFPDLDEPQSMFDIHYFSKNPK---PFFKFAKEIYPGKFTPSFGHRFIKVLEDK----GKLLRNYSQNIDTLEQIAGIKNIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERNQENLLSSIGNSDEVDTNIP-------IMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKVRPVAHIP 324
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079803.1 (SMESG000079803.1)

HSP 1 Score: 87.8113 bits (216), Expect = 3.233e-18
Identity = 74/242 (30.58%), Postives = 110/242 (45.45%), Query Frame = 1 
Query:   73 KNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPA------FLENPSLVWEFYHFRREI--CLKANPNAAHAALSKFEMKCKKENKQFTLI-TQNVDGLHRRAG--SENIISIHGEIFETKCMKCKNVKENFISPICEGLRDKGDPNSTE-NSSIPEESLPTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASF--------PYQVINRGVPVAEF 738
            KNI+++ GAGIS  SGIP FR      + N +   +    A      FL+NP     F+   +E+    K  PN  H     +  +  +E K    + TQN+DGL R AG    N++  HG      C++C                   D ++T+   SI +  +  C  CRG+++P++V+FGE+L P          +  DL +V+GTS  V+P AS         P  +INR  PV  F
Sbjct:  156 KNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFLQNPK---PFFALAKELFPSGKYRPNKVH-----YFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGE-----------------DYSATQLKESIDKSEICYCSKCRGIVKPDIVFFGEDL-PSKFHLFRSDFQQADLLLVMGTSLEVEPFASIVDSTRFGTPRVLINRQ-PVGVF 370
The following BLAST results are available for this feature:
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SIRT58.880e-8849.24sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT52.633e-8349.60sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT52.569e-7946.39sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT57.250e-5949.47sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT41.240e-2430.16sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sir-2.32.764e-2431.30NAD-dependent protein deacylase sir-2.3 [Source:U... [more]
sir-2.21.080e-2227.76NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.25.971e-2127.55NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.26.653e-2127.55NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.16.096e-2030.16NAD-dependent protein deacetylase sir-2.1 [Source... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sirt47.906e-1929.47gene:FBgn0029783 transcript:FBtr0070852[more]
Sirt12.629e-1829.54gene:FBgn0024291 transcript:FBtr0080434[more]
Sirt22.819e-1729.03gene:FBgn0038788 transcript:FBtr0083882[more]
Sirt22.819e-1729.03gene:FBgn0038788 transcript:FBtr0344243[more]
Sirt43.774e-1429.50gene:FBgn0029783 transcript:FBtr0070851[more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt55.421e-8750.57sirtuin 5 [Source:NCBI gene;Acc:436878][more]
sirt35.573e-1929.32sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762][more]
sirt36.357e-1929.32sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762][more]
sirt36.680e-1828.69sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762][more]
sirt41.606e-1725.70sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lin28a7.217e-8950.19lin-28 homolog A [Source:Xenbase;Acc:XB-GENE-49138... [more]
SIRT33.105e-2333.47sirtuin 3 [Source:NCBI gene;Acc:100487410][more]
SIRT33.302e-2333.47sirtuin 3 [Source:NCBI gene;Acc:100487410][more]
tspear9.149e-2131.87thrombospondin-type laminin G domain and EAR repea... [more]
tspear9.369e-2131.87thrombospondin-type laminin G domain and EAR repea... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sirt51.552e-8447.89sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt51.552e-8447.89sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt58.930e-8149.79sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt58.930e-8149.79sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt54.414e-8047.43sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5HZN8|SIR5A_XENLA3.719e-9051.34NAD-dependent protein deacylase sirtuin-5A, mitoch... [more]
sp|E1BRE2|SIR5_CHICK4.938e-8949.81NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sp|F7DKV7|SIR5_XENTR3.823e-8850.19NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sp|E9GD30|SIR5_DAPPU5.127e-8850.38NAD-dependent protein deacylase OS=Daphnia pulex O... [more]
sp|F7EZ75|SIR5_MACMU3.401e-8749.24NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1Y1KIE82.680e-9152.90NAD-dependent protein deacylase OS=Photinus pyrali... [more]
V3ZQA22.013e-9051.75NAD-dependent protein deacylase OS=Lottia gigantea... [more]
A0A5N5LC885.159e-9052.31Uncharacterized protein OS=Pangasianodon hypophtha... [more]
A0A212F1S91.003e-8952.87NAD-dependent protein deacylase OS=Danaus plexippu... [more]
A0A1B6F0Z91.945e-8952.29NAD-dependent protein deacylase OS=Cuerna arida OX... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt52.894e-8649.43sirtuin 5 [Source:NCBI gene;Acc:103031700][more]
ENSAMXT00000052214.11.457e-8246.56NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
ENSAMXT00000009390.23.408e-8144.84NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sirt52.745e-8047.69sirtuin 5 [Source:NCBI gene;Acc:103031700][more]
sirt51.418e-7843.77sirtuin 5 [Source:NCBI gene;Acc:103031700][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sirt42.765e-2125.71sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt25.250e-1929.86sirtuin 2 (silent mating type information regulati... [more]
sirt31.001e-1628.06sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762][more]
sirt64.409e-1524.01sirtuin 6 [Source:ZFIN;Acc:ZDB-GENE-031007-2][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
HST11.668e-1829.81NAD(+)-dependent histone deacetylase; essential su... [more]
SIR21.361e-1628.41Conserved NAD+ dependent histone deacetylase of th... [more]
HST22.990e-1227.35Cytoplasmic NAD(+)-dependent protein deacetylase; ... [more]
HST32.254e-1126.09Member of the Sir2 family of NAD(+)-dependent prot... [more]
HST44.291e-926.82NAD(+)-dependent protein deacetylase; deacetylatio... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO473621.825e-7646.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO358665.766e-2327.14Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO468133.312e-1929.73Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316848.820e-1828.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO484591.491e-1728.63Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt51.641e-9150.77sirtuin 5 [Source:NCBI gene;Acc:101162440][more]
sirt56.414e-8651.22sirtuin 5 [Source:NCBI gene;Acc:101162440][more]
ENSORLT00000021505.25.148e-8248.66NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
ENSORLT00000021506.27.338e-8248.84NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sirt44.931e-2027.80sirtuin 4 [Source:NCBI gene;Acc:101156953][more]
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BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000027361.10.000e+0100.00SMESG000027361.1[more]
SMESG000074693.11.328e-2126.91SMESG000074693.1[more]
SMESG000079103.18.964e-2032.10SMESG000079103.1[more]
SMESG000079103.19.334e-2032.10SMESG000079103.1[more]
SMESG000079803.13.233e-1830.58SMESG000079803.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30019748 ID=SMED30019748|Name=NAD-dependent protein deacylase|organism=Schmidtea mediterranea sexual|type=transcript|length=1525bp
ATCTATATAAATCTTATATGGTTTGAAATTTACATGAGTCAAATTGAATT
TAAACAAACGCTTAAATTAGCTAAGAATATTTTAGTAATTACCGGCGCTG
GAATTAGTGCTGATAGTGGCATTCCTACATTCCGTGGTTCTCGAGCTCTT
CGGTGGAGAAATTATGAATCCTGTAATTTGGCTACATTGCCAGCGTTTTT
GGAAAACCCGTCTCTTGTTTGGGAATTTTATCATTTTCGTCGTGAAATCT
GCTTGAAAGCCAATCCAAATGCTGCTCATGCTGCATTGTCGAAATTTGAA
ATGAAATGTAAGAAGGAAAATAAACAATTCACACTCATTACACAAAATGT
TGATGGTCTTCATCGACGAGCCGGTTCCGAAAATATTATTTCTATTCATG
GTGAGATATTTGAAACAAAGTGCATGAAATGTAAAAATGTGAAGGAAAAT
TTCATTAGCCCAATTTGTGAAGGATTACGAGATAAGGGAGATCCGAACTC
GACTGAAAACTCTAGTATTCCCGAAGAAAGTCTTCCTACATGCGAATTTT
GTCGGGGATTGTTGCGTCCAAATGTTGTCTGGTTTGGGGAAAATCTTCAT
CCTGATACTTTAGAAAAATCCTATGACGCAATCAAGAATTGTGACCTGTG
TGTTGTAATTGGAACTTCTGGAATCGTTCAACCGGTCGCTTCATTCCCAT
ATCAAGTAATTAATCGAGGCGTTCCCGTTGCTGAGTTCAATGTTGAGTCC
ACTGATATTTCAGGCCAAGTTCAATATTTTATTAGAGGCCCTGCTTCGTC
CACATTGCCACCATTGCTTGAATAATTTTCAATTAATGATTAATATTTTT
ATATCACTTTTTTGTGAAAACTATAAAATAATACTCGATCGATTTCATTG
GCTACGCGTTCGCAAATTTTGCAAACAGACAGACAAAGAAATTTTCTATC
TCGTTTCGAAATTCGCCAGAATTAAATTGGACAAATCGAGTGATTTTGTT
TCTAGTTTTTTTTTAATGAAAATCAATATAGACAAATATCGATATGGGAT
TACGTTGTAATATAAATAACATTTCCATAAAGCAATGGGAGAAAATAGAT
ATCGGTAAATGGGGGTCTTAGGGAGCATCTACTAAGGACGTCCATTATGA
AAGGGGAGGGACAGAAAGTGACAAATTGGAAGGGATGAATAATTGCTCAT
TTTTGGGGGGGGGCGTACTTAACGGATGCTCCCTTAAAGGTTTGAGATTT
GTTAGATGTTTAGTTGTTTATGAACGCCGTGCGAAATTTTCCTTTCTTTT
GACCCTATTTCAATCATTTATTAAAATTTCCTATTATTGATATTATTGAT
GTGGCATTATTAGTTGGAAGTCGAGCTGTCGCATGTGAAGGTGTAACGAC
AAAAAGTCGAAAAGAAAATCAGTTTCAACTTCGAAAGTATAATTTTTACG
AGTTGAACTCTTGTCAATTGAAGCAGAGGTAAAATGTCGAAAATATTAAA
TTTGTCTGGTTTTTGAAAAGGTCGT
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protein sequence of SMED30019748-orf-1

>SMED30019748-orf-1 ID=SMED30019748-orf-1|Name=SMED30019748-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=107bp
MLSPLIFQAKFNILLEALLRPHCHHCLNNFQLMINIFISLFCENYKIILD
RFHWLRVRKFCKQTDKEIFYLVSKFARIKLDKSSDFVSSFFLMKINIDKY
RYGITL*
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protein sequence of SMED30019748-orf-2

>SMED30019748-orf-2 ID=SMED30019748-orf-2|Name=SMED30019748-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=275bp
IYINLIWFEIYMSQIEFKQTLKLAKNILVITGAGISADSGIPTFRGSRAL
RWRNYESCNLATLPAFLENPSLVWEFYHFRREICLKANPNAAHAALSKFE
MKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKCKNVKEN
FISPICEGLRDKGDPNSTENSSIPEESLPTCEFCRGLLRPNVVWFGENLH
PDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVES
TDISGQVQYFIRGPASSTLPPLLE*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0006476protein deacetylation
GO:0036047peptidyl-lysine demalonylation
GO:0036048protein desuccinylation
GO:0036049peptidyl-lysine desuccinylation
Vocabulary: molecular function
TermDefinition
GO:0016740transferase activity
GO:0034979NAD-dependent protein deacetylase activity
GO:0070403NAD+ binding
GO:0008270zinc ion binding
GO:0016787hydrolase activity
GO:0036054protein-malonyllysine demalonylase activity
GO:0036055protein-succinyllysine desuccinylase activity
GO:0046872metal ion binding
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000018Category 4 cell
PLANA:0000034epidermis
Vocabulary: INTERPRO
TermDefinition
IPR003000Sirtuin
IPR026591Sirtuin_cat_small_dom_sf
IPR029035DHS-like_NAD/FAD-binding_dom
IPR026590Ssirtuin_cat_dom
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
GO:0005739mitochondrion
GO:0005829cytosol