Histone-lysine N-methyltransferase

Overview
NameHistone-lysine N-methyltransferase
Smed IDSMED30019720
Length (bp)937
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Histone-lysine N-methyltransferase (SMED30019720) t-SNE clustered cells

Violin plots show distribution of expression levels for Histone-lysine N-methyltransferase (SMED30019720) in cells (dots) of each of the 12 neoblast clusters.

 

back to top

 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Histone-lysine N-methyltransferase (SMED30019720) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Histone-lysine N-methyltransferase (SMED30019720) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top

 

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020



SMED30019720

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 21

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30019720h1SMcG0010730 SmedASXL_014954SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Smed sexual biotypeSMED30019720h1SMcG0010730 Contig51307uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30019720h1SMcG0010730 Contig51307newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
muscle cellSMED30019720h1SMcG0010730 dd_Smed_v4_9808_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
pharynxSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
protonephridiaSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
non-ciliated neuronSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cilated neuronSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30019720h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30019720h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30019720h1SMcG0010730 dd_Smed_v6_9808_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
body wall musculatureSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:30471994
Scimone et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30019720h1SMcG0010730 dd_Smed_v6_99_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Category 2 cellSMED30019720h1SMcG0010730 dd_Smed_v4_99_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
epidermisSMED30019720h1SMcG0010730 dd_Smed_v4_4755_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 68.5514 bits (166), Expect = 3.551e-12
Identity = 40/137 (29.20%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E T+   N+S K  I+K   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  259 TTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPR-PQRERAQWDIGIAHAEKALKMTREERIEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 68.5514 bits (166), Expect = 3.709e-12
Identity = 40/137 (29.20%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E T+   N+S K  I+K   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  259 TTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRK-PRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 68.5514 bits (166), Expect = 3.971e-12
Identity = 40/137 (29.20%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E T+   N+S K  I+K   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  259 TTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRK-PRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD3 (nuclear receptor binding SET domain protein 3 [Source:HGNC Symbol;Acc:HGNC:12767])

HSP 1 Score: 68.5514 bits (166), Expect = 4.200e-12
Identity = 40/137 (29.20%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E T+   N+S K  I+K   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  259 TTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRK-PRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Match: NSD2 (nuclear receptor binding SET domain protein 2 [Source:HGNC Symbol;Acc:HGNC:12766])

HSP 1 Score: 67.781 bits (164), Expect = 4.724e-12
Identity = 40/124 (32.26%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  424 EYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKK----VIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDR 771
            +Y VG L+W+KV  +PWWPCM+   P  + Y ++  +K      HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S        W+    +AEEA  M V++R
Sbjct:  219 KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGK--LRAQWEMGIVQAEEAASMSVEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0335014)

HSP 1 Score: 68.5514 bits (166), Expect = 1.991e-12
Identity = 38/139 (27.34%), Postives = 71/139 (51.08%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEM-FHKK-----------VIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIP-QSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNL 804
            Y VG L W KV S+ +WPCM+   P       M  H +            +HV +F    +R W+   ++++F G   FDD  +EL   + PK+   +  +P ++++ I+ ++ +EA+    +P  DR++ +  +Y+N+
Sbjct:  393 YQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENV 531
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Match: NSD (gene:FBgn0039559 transcript:FBtr0085267)

HSP 1 Score: 68.5514 bits (166), Expect = 2.028e-12
Identity = 38/139 (27.34%), Postives = 71/139 (51.08%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEM-FHKK-----------VIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIP-QSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNL 804
            Y VG L W KV S+ +WPCM+   P       M  H +            +HV +F    +R W+   ++++F G   FDD  +EL   + PK+   +  +P ++++ I+ ++ +EA+    +P  DR++ +  +Y+N+
Sbjct:  393 YQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENV 531
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 77.0258 bits (188), Expect = 4.015e-15
Identity = 42/137 (30.66%), Postives = 70/137 (51.09%), Query Frame = 1 
Query:  403 TQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISY 795
            T   TS+EY +G L+WAKV ++PWWPCM+   P+ N +  +  +  K  HV +FG   +R W+     + ++ + +FD+   E    ++     QK   PQS+ +     W+     AE A+ M  ++R + Y   Y
Sbjct:  345 TSTGTSQEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRGCKEYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKE--RAQWEVGVGHAEAALQMTREERNENYTFIY 479
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 76.6406 bits (187), Expect = 4.898e-15
Identity = 42/137 (30.66%), Postives = 70/137 (51.09%), Query Frame = 1 
Query:  403 TQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISY 795
            T   TS+EY +G L+WAKV ++PWWPCM+   P+ N +  +  +  K  HV +FG   +R W+     + ++ + +FD+   E    ++     QK   PQS+ +     W+     AE A+ M  ++R + Y   Y
Sbjct:  345 TSTGTSQEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRGCKEYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKE--RAQWEVGVGHAEAALQMTREERNENYTFIY 479
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 74.7146 bits (182), Expect = 2.587e-14
Identity = 42/137 (30.66%), Postives = 70/137 (51.09%), Query Frame = 1 
Query:  403 TQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISY 795
            T   TS+EY +G L+WAKV ++PWWPCM+   P+ N +  +  +  K  HV +FG   +R W+     + ++ + +FD+   E    ++     QK   PQS+ +     W+     AE A+ M  ++R + Y   Y
Sbjct:  345 TSTGTSQEYEIGDLVWAKVGTYPWWPCMVSSDPQSNVHTRINTRGCKEYHVQFFGSVPERAWIHEKRTVVYKSENQFDELQAETLRKSTNPTEKQKLLKPQSQKE--RAQWEVGVGHAEAALQMTREERNENYTFIY 479
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 70.8626 bits (172), Expect = 4.776e-13
Identity = 44/147 (29.93%), Postives = 75/147 (51.02%), Query Frame = 1 
Query:  397 SSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV-------IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNII-QKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISYKN 801
            S T+  ++  + VG ++W KV  +PWWPCMI   PE N +   F  KV        HV YFG   +RG+V    +++F GK ++    +    N  P NI  +K  +P+     F + W+    +A+EA+ +  ++R+  +   Y++
Sbjct:  273 SYTETQSNVHFSVGDVIWTKVSGYPWWPCMITTDPEFNMH---FRSKVNSRTGLLYHVQYFGDTPERGYVFEKCIVTFSGKHQYQSLSR---SNQLPINISGRKRAVPRK----FRQKWEIGVSQAKEALGLLTEERLAKFSFVYED 409
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 69.707 bits (169), Expect = 1.168e-12
Identity = 45/157 (28.66%), Postives = 77/157 (49.04%), Query Frame = 1 
Query:  367 HVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV-------IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNII-QKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISYKN 801
            + +G      S T+  ++  + VG ++W KV  +PWWPCMI   PE N +   F  KV        HV YFG   +RG+V    + +F GK ++    +    N  P NI  +K  +P+     F + W+    +A+EA+ +  ++R+  +   Y++
Sbjct:  263 YAQGENDVKESYTETQSNVHFSVGDVIWTKVSGYPWWPCMITTDPEFNMH---FRSKVNSRTGLLYHVQYFGDTPERGYVFEKCIGTFSGKHQYQSLSR---SNQLPINISGRKRAVPRK----FRQKWEIGVSQAKEALGLLTEERLAKFSFVYED 409
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 63.929 bits (154), Expect = 1.136e-10
Identity = 35/139 (25.18%), Postives = 67/139 (48.20%), Query Frame = 1 
Query:  391 FSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTEN--NSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +S      T   ++VG L+W+KV + PWWPCM+   P+ + + ++  +  +  HV +F    +R WV    +  + G+ +++  V E +    N  + +  +   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  220 YSQLVNVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIY 358
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 63.1586 bits (152), Expect = 2.102e-10
Identity = 35/136 (25.74%), Postives = 67/136 (49.26%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTEN--NSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            S +  T   ++VG L+W+KV + PWWPCM+   P+ + + ++  +  +  HV +F    +R WV    +  + G+ +++  V E +    N  + +  +   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  252 SPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIY 387
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 63.1586 bits (152), Expect = 2.294e-10
Identity = 35/136 (25.74%), Postives = 67/136 (49.26%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTEN--NSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            S +  T   ++VG L+W+KV + PWWPCM+   P+ + + ++  +  +  HV +F    +R WV    +  + G+ +++  V E +    N  + +  +   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  252 SPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIY 387
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 63.1586 bits (152), Expect = 2.352e-10
Identity = 35/136 (25.74%), Postives = 67/136 (49.26%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTEN--NSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            S +  T   ++VG L+W+KV + PWWPCM+   P+ + + ++  +  +  HV +F    +R WV    +  + G+ +++  V E +    N  + +  +   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  245 SPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIY 380
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Match: NSD3 (Triosephosphate isomerase [Source:UniProtKB/Swiss-Prot;Acc:B0BM40])

HSP 1 Score: 63.1586 bits (152), Expect = 2.359e-10
Identity = 35/136 (25.74%), Postives = 67/136 (49.26%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTEN--NSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            S +  T   ++VG L+W+KV + PWWPCM+   P+ + + ++  +  +  HV +F    +R WV    +  + G+ +++  V E +    N  + +  +   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  252 SPEVRTGVWFHVGDLVWSKVGTFPWWPCMVSCDPQLHVHSKINTRGAREYHVQFFSSEPERAWVHEKRMKEYRGEQQYEQLVAEDSAKACNQSEKLKMRKPRPQRERVQWEIGIAHAEKALRMTREERIEQYTFIY 387
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 66.2402 bits (160), Expect = 1.268e-11
Identity = 42/124 (33.87%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 66.2402 bits (160), Expect = 1.272e-11
Identity = 42/124 (33.87%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 66.2402 bits (160), Expect = 1.272e-11
Identity = 42/124 (33.87%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 66.2402 bits (160), Expect = 1.272e-11
Identity = 42/124 (33.87%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  220 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Match: Nsd2 (nuclear receptor binding SET domain protein 2 [Source:MGI Symbol;Acc:MGI:1276574])

HSP 1 Score: 66.2402 bits (160), Expect = 1.335e-11
Identity = 42/124 (33.87%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  202 YNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 322
[Close]
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q9BZ95|NSD3_HUMAN (Histone-lysine N-methyltransferase NSD3 OS=Homo sapiens OX=9606 GN=NSD3 PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 2.017e-11
Identity = 40/137 (29.20%), Postives = 73/137 (53.28%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E T+   N+S K  I+K   PQ     +      AE+A+ M  ++RI+ Y   Y
Sbjct:  259 TTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRK-PRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8MT36|MES4_DROME (Probable histone-lysine N-methyltransferase Mes-4 OS=Drosophila melanogaster OX=7227 GN=Mes-4 PE=1 SV=2)

HSP 1 Score: 68.5514 bits (166), Expect = 2.033e-11
Identity = 38/139 (27.34%), Postives = 71/139 (51.08%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEM-FHKK-----------VIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIP-QSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNL 804
            Y VG L W KV S+ +WPCM+   P       M  H +            +HV +F    +R W+   ++++F G   FDD  +EL   + PK+   +  +P ++++ I+ ++ +EA+    +P  DR++ +  +Y+N+
Sbjct:  393 YQVGDLFWGKVFSYCFWPCMVCPDPLGQIVGNMPSHPQRSSLDNANVPIQVHVRFFADNGRRNWIKPENLLTFAGLKAFDDMREELRIKHGPKSAKYRQMVPKRTKVVIWRQAIEEAQAMTQIPYSDRLEKFYQTYENV 531
[Close]
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|O96028|NSD2_HUMAN (Histone-lysine N-methyltransferase NSD2 OS=Homo sapiens OX=9606 GN=NSD2 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 6.125e-11
Identity = 40/124 (32.26%), Postives = 64/124 (51.61%), Query Frame = 1 
Query:  424 EYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKK----VIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDR 771
            +Y VG L+W+KV  +PWWPCM+   P  + Y ++  +K      HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S        W+    +AEEA  M V++R
Sbjct:  219 KYNVGDLVWSKVSGYPWWPCMVSADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQAPTKAEKIKLLKPISGK--LRAQWEMGIVQAEEAASMSVEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q6P2L6|NSD3_MOUSE (Histone-lysine N-methyltransferase NSD3 OS=Mus musculus OX=10090 GN=Nsd3 PE=1 SV=2)

HSP 1 Score: 66.6254 bits (161), Expect = 9.822e-11
Identity = 38/137 (27.74%), Postives = 72/137 (52.55%), Query Frame = 1 
Query:  400 STQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV--IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTE---NNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +T+ +T  ++ VG L+W+KV ++PWWPCM+   P+   + ++  +     HV +F    +R WV    V  ++G  ++++ + E  +   N+S K  I+K   PQ     +      AE+A+ M  ++R++ Y   Y
Sbjct:  259 TTETSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHSKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHEQYEELLAEAAKQASNHSEKQKIRK-PRPQRERAQWDIGIAHAEKALKMTREERVEQYTFIY 394
[Close]
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Match: sp|Q8BVE8|NSD2_MOUSE (Histone-lysine N-methyltransferase NSD2 OS=Mus musculus OX=10090 GN=Nsd2 PE=1 SV=2)

HSP 1 Score: 65.0846 bits (157), Expect = 2.691e-10
Identity = 42/125 (33.60%), Postives = 65/125 (52.00%), Query Frame = 1 
Query:  424 EYYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQS-RMKIFSESWK----EAEEAMMMPVKDR 771
            +Y VG L+W+KV  +PWWPCM+   P   N  K    KK     HV +FG   +R W+   S+++FEG+ +F+   +E  +    K    K   P S R++     W+    +AEEA  M +++R
Sbjct:  219 KYNVGDLVWSKVSGYPWWPCMVSADPLLHNHTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEEQFEKLCQESAKQAPTKAEKIKLLKPISGRLRA---QWEMGIVQAEEAASMSIEER 340
[Close]
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A183L3E9 (PWWP domain-containing protein OS=Schistosoma curassoni OX=6186 GN=SCUD_LOCUS21857 PE=4 SV=1)

HSP 1 Score: 112.849 bits (281), Expect = 5.529e-26
Identity = 56/129 (43.41%), Postives = 84/129 (65.12%), Query Frame = 1 
Query:  412 NTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFY-KEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKE---LTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            + S++Y VG + WAKV SHPWWPCM+Y+SP+ + Y KE     + HV + GP V+R WVS N+++ F GK  FD++V+E    T++ S K   +  ++  S   I+ +SWKEAE AM + V +RI+ +G
Sbjct:    3 SISDDYQVGNIFWAKVGSHPWWPCMVYHSPDGDSYVKEKGRSFIYHVQFLGPLVERAWVSANNLIPFSGKKNFDEYVQEKLRTTKDKSEKIKFESKSV-SSNKSIWIQSWKEAEVAMNLTVNERIERFG 130
[Close]
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A183LQ36 (PWWP domain-containing protein OS=Schistosoma margrebowiei OX=48269 PE=4 SV=1)

HSP 1 Score: 109.383 bits (272), Expect = 1.031e-24
Identity = 55/128 (42.97%), Postives = 81/128 (63.28%), Query Frame = 1 
Query:  412 NTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFY-KEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKE--LTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            + S++Y VG + WAKV SHPWWPCM+Y+SP+ + Y KE     + HV + GP V+R WVS N+++ F GK  FD++V+E   T  +  + I  +     S   I+ +SWKEAE AM + V +RI+ +G
Sbjct:    3 SISDDYQVGNIFWAKVGSHPWWPCMVYHSPDGDSYVKEKGRSFIYHVQFLGPLVERAWVSANNLIPFSGKKHFDEYVQEKLRTTKDKSEKIKFESKSVSSSKSIWIQSWKEAEVAMNLTVNERIERFG 130
[Close]
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A430QS17 (Histone-lysine N-methyltransferase NSD2 OS=Schistosoma bovis OX=6184 GN=DC041_0006191 PE=4 SV=1)

HSP 1 Score: 114.39 bits (285), Expect = 2.559e-24
Identity = 56/127 (44.09%), Postives = 83/127 (65.35%), Query Frame = 1 
Query:  418 SEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFY-KEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKE---LTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            S++Y VG + WAKV SHPWWPCM+Y+SP+ + Y KE     + HV + GP V+R WVS N+++ F GK  FD++V+E    T++ S K   +  ++  S   I+ +SWKEAE AM + V +RI+ +G
Sbjct:    5 SDDYQVGNIFWAKVGSHPWWPCMVYHSPDGDSYVKEKGRSFIYHVQFLGPLVERAWVSANNLIPFSGKKNFDEYVQEKLRTTKDKSEKIKFESKSV-SSNKSIWIQSWKEAEVAMNLTVNERIERFG 130
[Close]
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A183QI82 (PWWP domain-containing protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 108.612 bits (270), Expect = 2.796e-24
Identity = 55/128 (42.97%), Postives = 81/128 (63.28%), Query Frame = 1 
Query:  412 NTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFY-KEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKE--LTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            + S++Y VG + WAKV SHPWWPCM+Y+SP+ + Y KE     + HV + GP V+R WVS N+++ F GK  FD++V+E   T  +  + I  +     S   I+ +SWKEAE AM + V +RI+ +G
Sbjct:    3 SISDDYQVGNIFWAKVGSHPWWPCMVYHSPDGDSYVKEKGRSFIYHVQFLGPLVERAWVSANNLIPFSGKKNFDEYVQEKLRTCKDKSEKIKFESKSVSSSKSIWIQSWKEAEVAMNLTVNERIEKFG 130
[Close]
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Match: A0A4S2LAE9 (Uncharacterized protein OS=Opisthorchis felineus OX=147828 GN=CRM22_009922 PE=4 SV=1)

HSP 1 Score: 114.005 bits (284), Expect = 3.475e-24
Identity = 52/126 (41.27%), Postives = 79/126 (62.70%), Query Frame = 1 
Query:  421 EEYYVGRLLWAKVKSHPWWPCMIYYSPE-KNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKE---LTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            + + +G + WAKV SHPWWPCM+YY+P+ ++F +        HV + GP V+R WV  N+++ F GK KFD++V+E     ++ + KN     +   SR  I+ +SW+EAEEAM MP   RI+ +G
Sbjct:    6 DSFELGSVFWAKVGSHPWWPCMVYYTPDGESFIRNTHRGACYHVQFLGPLVERAWVYPNNLIPFNGKKKFDEYVQEKLKACKDKNEKNKFDSKSTSSSR-NIWVQSWREAEEAMNMPPDKRIEKFG 130
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 72.0182 bits (175), Expect = 1.595e-13
Identity = 34/141 (24.11%), Postives = 75/141 (53.19%), Query Frame = 1 
Query:  397 SSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV-------IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYK 798
            + +QE +  ++ VG ++W KV  +PWWPC++   PE N +   F +K         H+ YF    +RG+++  ++++F GK +F +  +   + N+  +  ++ +IP+     +     +A EA+ +  ++R+  +  +Y+
Sbjct:  278 THSQEQSHAQFAVGDVVWTKVSGYPWWPCVVTTDPETNLH---FRQKANSRTGSFYHIQYFSDAPERGYIAGKNMVTFSGKEQFPELCRGTRQTNAHTD-ARRLSIPRKLRISWEMGISQATEAITLSAEERLAKFSFTYE 414
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 70.0922 bits (170), Expect = 4.551e-13
Identity = 38/128 (29.69%), Postives = 66/128 (51.56%), Query Frame = 1 
Query:  424 EYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISY 795
            EY +G L+WAKV + PWWPCM+   P+    + + H++  HV +FG   +R W+    ++ ++G  +F++   E     +     QK   PQS+ +     W+     AE A++M  ++R + Y   Y
Sbjct:  111 EYEIGDLVWAKVGTFPWWPCMVSSDPQLKKGQLLCHREY-HVQFFGSVAERAWIHEKRIVVYKGASQFEELQAETLRKTTNPTERQKLLKPQSQHE--RAQWEVGVGHAESALLMSREERNENYTFIY 235
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:ZFIN;Acc:ZDB-GENE-050324-2])

HSP 1 Score: 68.9366 bits (167), Expect = 1.612e-12
Identity = 41/150 (27.33%), Postives = 71/150 (47.33%), Query Frame = 1 
Query:  364 QHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWK----EAEEAMMMPVKDRIDVYGISY 795
            + +K  K   S  T      EY +G L+WAKV + PWWPCM+   P+   +  +  +  +  HV +FG   +R W+    ++ ++G  +F++   E     +     QK   PQS+ +     W+     AE A++M  ++R + Y   Y
Sbjct:  329 KELKVEKHFPSVITSTGVCVEYEIGDLVWAKVGTFPWWPCMVSSDPQLKVHIRINTRGHREYHVQFFGSVAERAWIHEKRIVVYKGASQFEELQAETLRKTTNPTERQKLLKPQSQHE--RAQWEVGVGHAESALLMSREERNENYTFIY 476
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 68.5514 bits (166), Expect = 2.466e-12
Identity = 34/141 (24.11%), Postives = 71/141 (50.35%), Query Frame = 1 
Query:  397 SSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV-------IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYK 798
            + +QE +  ++ VG ++W KV  +PWWPC++   PE N +   F +K         H+ YF    +RG+++  ++++F GK +F +  +   + N         +IP+     +     +A EA+ +  ++R+  +  +Y+
Sbjct:  273 THSQEQSHAQFAVGDVVWTKVSGYPWWPCVVTTDPETNLH---FRQKANSRTGSFYHIQYFSDAPERGYIAGKNMVTFSGKEQFPELCRGTRQTN--------LSIPRKLRISWEMGISQATEAITLSAEERLAKFSFTYE 402
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Match: ENSAMXT00000020465.2 (zinc finger CW-type PWWP domain protein 1 [Source:NCBI gene;Acc:103033755])

HSP 1 Score: 54.299 bits (129), Expect = 8.636e-8
Identity = 25/64 (39.06%), Postives = 34/64 (53.12%), Query Frame = 1 
Query:  436 GRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV------IHVAYFGPYVQRGWVSINSVMSF 609
            G L+W +   H WWP M+   PE + Y E FH+K        HV YFG  V  GWV  ++V ++
Sbjct:  277 GSLVWVQQNGHFWWPAMVQRDPETDDYLE-FHRKTDLDPCKCHVTYFGDPVCIGWVLCSNVRNY 339
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:ZFIN;Acc:ZDB-GENE-030131-2581])

HSP 1 Score: 62.7734 bits (151), Expect = 3.356e-11
Identity = 27/85 (31.76%), Postives = 45/85 (52.94%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV------IHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNS 663
            Y +G ++WAK+  HPWWPCM+   P+   +  +   +V       HV +FG   +R WV   S++ F  + +++  V EL +  S
Sbjct:  127 YSIGDVVWAKISGHPWWPCMVSCDPKLGIHMRVKVGQVKSFTRQYHVQFFGEAAERAWVCYRSLVMFSTREQYELLVSELAKRTS 211
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004277.1 (pep scaffold:Pmarinus_7.0:GL480472:363:17009:-1 gene:ENSPMAG00000003901.1 transcript:ENSPMAT00000004277.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.151 bits (139), Expect = 8.891e-10
Identity = 39/129 (30.23%), Postives = 59/129 (45.74%), Query Frame = 1 
Query:  436 GRLLWAKVKSHPWWPCMIYYSPEKNFY---KEMFHKKVIH---VAYFGPYVQRGWVSINSVMSFEGKLKFDD-------HVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVY 783
            G L+W+KV  HPWWPC++   P    +   KE     V H   V   G  VQR WV+  S + FEG+ +F+            + E + PK  + K+   + R + + E   E  +A  +   +R D Y
Sbjct:    1 GDLVWSKVAGHPWWPCVVTSDPNVGSHTRVKEYAKSTVRHYHIVLLGGGVVQRTWVADKSTVPFEGQHQFEQLQGDAPWGGSAVNEASGPK--LSKHFSAKVRAQ-WEEGMAEVAKAQPLSCDERHDAY 126
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004270.1 (pep scaffold:Pmarinus_7.0:GL480472:363:17024:-1 gene:ENSPMAG00000003901.1 transcript:ENSPMAT00000004270.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 57.7658 bits (138), Expect = 1.135e-9
Identity = 39/132 (29.55%), Postives = 60/132 (45.45%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFY---KEMFHKKVIH---VAYFGPYVQRGWVSINSVMSFEGKLKFDD-------HVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVY 783
            +  G L+W+KV  HPWWPC++   P    +   KE     V H   V   G  VQR WV+  S + FEG+ +F+            + E + PK  + K+   + R + + E   E  +A  +   +R D Y
Sbjct:    3 HIPGDLVWSKVAGHPWWPCVVTSDPNVGSHTRVKEYAKSTVRHYHIVLLGGGVVQRTWVADKSTVPFEGQHQFEQLQGDAPWGGSAVNEASGPK--LSKHFSAKVRAQ-WEEGMAEVAKAQPLSCDERHDAY 131
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004276.1 (pep scaffold:Pmarinus_7.0:GL480472:363:17009:-1 gene:ENSPMAG00000003901.1 transcript:ENSPMAT00000004276.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 57.7658 bits (138), Expect = 1.162e-9
Identity = 39/129 (30.23%), Postives = 59/129 (45.74%), Query Frame = 1 
Query:  436 GRLLWAKVKSHPWWPCMIYYSPEKNFY---KEMFHKKVIH---VAYFGPYVQRGWVSINSVMSFEGKLKFDD-------HVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVY 783
            G L+W+KV  HPWWPC++   P    +   KE     V H   V   G  VQR WV+  S + FEG+ +F+            + E + PK  + K+   + R + + E   E  +A  +   +R D Y
Sbjct:    1 GDLVWSKVAGHPWWPCVVTSDPNVGSHTRVKEYAKSTVRHYHIVLLGGGVVQRTWVADKSTVPFEGQHQFEQLQGDAPWGGSAVNEASGPK--LSKHFSAKVRAQ-WEEGMAEVAKAQPLSCDERHDAY 126
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Match: msh6 (mutS homolog 6 (E. coli) [Source:ZFIN;Acc:ZDB-GENE-020905-3])

HSP 1 Score: 51.9878 bits (123), Expect = 1.072e-7
Identity = 23/65 (35.38%), Postives = 33/65 (50.77%), Query Frame = 1 
Query:  424 EYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKV-IHVAYFGPYVQRGWVSINSVMSFEG 615
            E+  G LLWAK++ +PWWP ++Y  PE   +     K + IHV +F     R WV       + G
Sbjct:   96 EFQPGDLLWAKLEGYPWWPSLVYDHPESGAHTRGRGKSLRIHVQFFDTPPTRSWVGAKYCKPYNG 160
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Match: EDO40989 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5K0])

HSP 1 Score: 68.1662 bits (165), Expect = 9.737e-13
Identity = 38/124 (30.65%), Postives = 63/124 (50.81%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVI----HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYG 786
            +  G ++WAK+  +PWWP M+   P+  +Y E      I    HV +FG  V R WV+     SF         V+ELT +  P++I       ++  K   ++  +A +A+ +PV++R+ VYG
Sbjct:  124 FPTGAIVWAKLAGYPWWPAMMEDDPDYGYYYETDLDDRIPISYHVVFFGKDVSRAWVN-----SF--------SVRELTADEEPEDIGNIVVRKKNYKKQLDDANGQARQALSLPVQERLAVYG 234
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:NCBI gene;Acc:101156018])

HSP 1 Score: 75.0998 bits (183), Expect = 1.730e-14
Identity = 38/129 (29.46%), Postives = 66/129 (51.16%), Query Frame = 1 
Query:  421 EEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKY--TIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +E+ +G L+W+KV ++PWWPCM+   P+   +  +  +  +  HV +FG   +R W+    ++ ++GK +FD+   E     +     QK    IPQ     +      AE+A +M  ++RID Y   Y
Sbjct:  363 KEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRINTRGHREYHVQFFGSVAERAWIHEKRIVVYQGKQQFDELQAETLRKATNPVERQKLLKPIPQRERSQWEVGVGHAEDAFLMTRQERIDNYTFIY 491
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd3 (nuclear receptor binding SET domain protein 3 [Source:NCBI gene;Acc:101156018])

HSP 1 Score: 75.0998 bits (183), Expect = 1.754e-14
Identity = 38/129 (29.46%), Postives = 66/129 (51.16%), Query Frame = 1 
Query:  421 EEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK--KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKY--TIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            +E+ +G L+W+KV ++PWWPCM+   P+   +  +  +  +  HV +FG   +R W+    ++ ++GK +FD+   E     +     QK    IPQ     +      AE+A +M  ++RID Y   Y
Sbjct:  363 KEFVIGDLVWSKVGTYPWWPCMVSSDPQMKVHTRINTRGHREYHVQFFGSVAERAWIHEKRIVVYQGKQQFDELQAETLRKATNPVERQKLLKPIPQRERSQWEVGVGHAEDAFLMTRQERIDNYTFIY 491
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: nsd2 (nuclear receptor binding SET domain protein 2 [Source:NCBI gene;Acc:101172132])

HSP 1 Score: 66.6254 bits (161), Expect = 8.108e-12
Identity = 37/128 (28.91%), Postives = 66/128 (51.56%), Query Frame = 1 
Query:  436 GRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVI-------HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNS-PKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISY 795
            G ++W KV  +PWWPCM+   PE N + +   K V        HV YFG   +RG+V   +++SF G+ ++ +  + +    S   +     ++PQ     ++    +A+EA+ MP  +R++ +G  Y
Sbjct:  219 GDVVWTKVSGYPWWPCMVTNDPEFNSHFKEKQKAVTCELDILYHVQYFGDAAERGYVFERNMVSFSGEEQYPELCQGIRLPGSCVTHRKTSASVPQKLQAQWNMGVIQAKEALCMPPDERLENFGFLY 346
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: ENSORLT00000006947.2 (histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific [Source:NCBI gene;Acc:101160669])

HSP 1 Score: 66.2402 bits (160), Expect = 1.496e-11
Identity = 37/116 (31.90%), Postives = 58/116 (50.00%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHK-----KVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMP 759
            Y  G L+WAK    PWWPC + Y P++ F+ +M        ++  +   G   +R WV    ++ FEG  +F+D +  L      K    KYTIP+S +  +  S  EAE  +++P
Sbjct:  284 YSEGDLVWAKFNRRPWWPCRVIYDPDQGFHTKMKVPSPRPCRMYFLETVGEVAERAWVPNGVILPFEGGHQFED-LPVLRRRGKQKEKDYKYTIPKSLLTAWKVSVAEAE--LLLP 396
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Match: msh6 (mutS homolog 6 [Source:NCBI gene;Acc:101160935])

HSP 1 Score: 60.077 bits (144), Expect = 1.233e-9
Identity = 29/84 (34.52%), Postives = 45/84 (53.57%), Query Frame = 1 
Query:  376 GNKRKFSSS---TQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSP-EKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEG 615
            G K+ F S    T+E++S     G L+WAK++ HPWWPCM+   P     ++     + +HV +F     RGWVS   +  ++G
Sbjct:   73 GIKQLFGSKKTPTEESSSPMCKAGALVWAKLEGHPWWPCMVVPQPLTGQLFRGRGRDQRVHVHFFDEPPTRGWVSTRYIREYQG 156
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1)

HSP 1 Score: 532.717 bits (1371), Expect = 0.000e+0
Identity = 300/303 (99.01%), Postives = 301/303 (99.34%), Query Frame = 1 
Query:   28 MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYDIMPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRXXXXXXXXXXXXXXXXKQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGXXXXXXXXXXXXXXXXXXXXXXXPCKKQKIVAETFEFQNLKL 936
            MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYD+MPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRTRKSITNSTST SSE KQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAETFEFQNLKL
Sbjct:    1 MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYDLMPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRTRKSITNSTSTASSELKQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAETFEFQNLKL 303
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000039925.1 (SMESG000039925.1)

HSP 1 Score: 522.316 bits (1344), Expect = 5.153e-178
Identity = 300/318 (94.34%), Postives = 301/318 (94.65%), Query Frame = 1 
Query:   28 MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYDIMPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRXXXXXXXXXXXXXXXXKQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGXXXXXXXXXXXXXXXXXXXXXXXPCKKQKIVAET---------------FEFQNLKL 936
            MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYD+MPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRTRKSITNSTST SSE KQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAET               FEFQNLKL
Sbjct:    1 MNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYDLMPIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSLRTRKSITNSTSTASSELKQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAETALTIVYIGRFSIVLNFEFQNLKL 318
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000015015.1 (SMESG000015015.1)

HSP 1 Score: 51.6026 bits (122), Expect = 4.295e-7
Identity = 34/132 (25.76%), Postives = 65/132 (49.24%), Query Frame = 1 
Query:  394 SSSTQENTSEEYYVGRLLWAKVKSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGI 789
            S+ T+++ S+ Y VG+++  KV  +PWWPCM+   P  N       +  + V+YFG      ++  +  M  + K  F++  K    +N  K  + +    + ++ +   +WKE E A ++    R ++Y I
Sbjct:   22 SNRTEDSRSKSYKVGQIICGKVGKYPWWPCMVNTIPTSN-------EPRVLVSYFGKKNDYSYLFDDCTMYAQTKSDFENIFK---LHNHDKKTLARLAHYKKQLDL---AWKEVEIASLLDENSRFELYKI 140
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000017482.1 (SMESG000017482.1)

HSP 1 Score: 49.2914 bits (116), Expect = 2.207e-6
Identity = 30/128 (23.44%), Postives = 57/128 (44.53%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKN-FYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYK 798
            Y +G ++WAK     WWP +I   P+ + FY    H   +   HV +    V R W++   + +F GK                   + KY   ++ +K  S++ + AEE + + +++ +D Y  + +
Sbjct:  202 YTLGSVVWAKAPGFCWWPAIIDEDPDLDMFYWCYEHSDDVSHYHVTFLDDDVSRSWITTKDIKAFNGKADMSSMK------------LNKYK--KNYLKSLSKAVERAEECLTLSLQECLDKYSFAVR 315
[Close]
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Match: SMESG000017482.1 (SMESG000017482.1)

HSP 1 Score: 48.9062 bits (115), Expect = 2.418e-6
Identity = 30/128 (23.44%), Postives = 57/128 (44.53%), Query Frame = 1 
Query:  427 YYVGRLLWAKVKSHPWWPCMIYYSPEKN-FYKEMFHKKVI---HVAYFGPYVQRGWVSINSVMSFEGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMPVKDRIDVYGISYK 798
            Y +G ++WAK     WWP +I   P+ + FY    H   +   HV +    V R W++   + +F GK                   + KY   ++ +K  S++ + AEE + + +++ +D Y  + +
Sbjct:  185 YTLGSVVWAKAPGFCWWPAIIDEDPDLDMFYWCYEHSDDVSHYHVTFLDDDVSRSWITTKDIKAFNGKADMSSMK------------LNKYK--KNYLKSLSKAVERAEECLTLSLQECLDKYSFAVR 298
The following BLAST results are available for this feature:
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NSD33.551e-1229.20nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD33.709e-1229.20nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD33.971e-1229.20nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD34.200e-1229.20nuclear receptor binding SET domain protein 3 [Sou... [more]
NSD24.724e-1232.26nuclear receptor binding SET domain protein 2 [Sou... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
NSD1.991e-1227.34gene:FBgn0039559 transcript:FBtr0335014[more]
NSD2.028e-1227.34gene:FBgn0039559 transcript:FBtr0085267[more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd34.015e-1530.66nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd34.898e-1530.66nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd32.587e-1430.66nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd24.776e-1329.93nuclear receptor binding SET domain protein 2 [Sou... [more]
nsd21.168e-1228.66nuclear receptor binding SET domain protein 2 [Sou... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
NSD31.136e-1025.18Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
NSD32.102e-1025.74Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
NSD32.294e-1025.74Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
NSD32.352e-1025.74Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
NSD32.359e-1025.74Triosephosphate isomerase [Source:UniProtKB/Swiss... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Nsd21.268e-1133.87nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd21.272e-1133.87nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd21.272e-1133.87nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd21.272e-1133.87nuclear receptor binding SET domain protein 2 [Sou... [more]
Nsd21.335e-1133.87nuclear receptor binding SET domain protein 2 [Sou... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q9BZ95|NSD3_HUMAN2.017e-1129.20Histone-lysine N-methyltransferase NSD3 OS=Homo sa... [more]
sp|Q8MT36|MES4_DROME2.033e-1127.34Probable histone-lysine N-methyltransferase Mes-4 ... [more]
sp|O96028|NSD2_HUMAN6.125e-1132.26Histone-lysine N-methyltransferase NSD2 OS=Homo sa... [more]
sp|Q6P2L6|NSD3_MOUSE9.822e-1127.74Histone-lysine N-methyltransferase NSD3 OS=Mus mus... [more]
sp|Q8BVE8|NSD2_MOUSE2.691e-1033.60Histone-lysine N-methyltransferase NSD2 OS=Mus mus... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A183L3E95.529e-2643.41PWWP domain-containing protein OS=Schistosoma cura... [more]
A0A183LQ361.031e-2442.97PWWP domain-containing protein OS=Schistosoma marg... [more]
A0A430QS172.559e-2444.09Histone-lysine N-methyltransferase NSD2 OS=Schisto... [more]
A0A183QI822.796e-2442.97PWWP domain-containing protein OS=Schistosoma rodh... [more]
A0A4S2LAE93.475e-2441.27Uncharacterized protein OS=Opisthorchis felineus O... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd21.595e-1324.11nuclear receptor binding SET domain protein 2 [Sou... [more]
nsd34.551e-1329.69nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd31.612e-1227.33nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd22.466e-1224.11nuclear receptor binding SET domain protein 2 [Sou... [more]
ENSAMXT00000020465.28.636e-839.06zinc finger CW-type PWWP domain protein 1 [Source:... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd23.356e-1131.76nuclear receptor binding SET domain protein 2 [Sou... [more]
ENSPMAT00000004277.18.891e-1030.23pep scaffold:Pmarinus_7.0:GL480472:363:17009:-1 ge... [more]
ENSPMAT00000004270.11.135e-929.55pep scaffold:Pmarinus_7.0:GL480472:363:17024:-1 ge... [more]
ENSPMAT00000004276.11.162e-930.23pep scaffold:Pmarinus_7.0:GL480472:363:17009:-1 ge... [more]
msh61.072e-735.38mutS homolog 6 (E. coli) [Source:ZFIN;Acc:ZDB-GENE... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO409899.737e-1330.65Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
nsd31.730e-1429.46nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd31.754e-1429.46nuclear receptor binding SET domain protein 3 [Sou... [more]
nsd28.108e-1228.91nuclear receptor binding SET domain protein 2 [Sou... [more]
ENSORLT00000006947.21.496e-1131.90histone-lysine N-methyltransferase, H3 lysine-36 a... [more]
msh61.233e-934.52mutS homolog 6 [Source:NCBI gene;Acc:101160935][more]
back to top
BLAST of Histone-lysine N-methyltransferase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000039925.10.000e+099.01SMESG000039925.1[more]
SMESG000039925.15.153e-17894.34SMESG000039925.1[more]
SMESG000015015.14.295e-725.76SMESG000015015.1[more]
SMESG000017482.12.207e-623.44SMESG000017482.1[more]
SMESG000017482.12.418e-623.44SMESG000017482.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30019720 ID=SMED30019720|Name=Histone-lysine N-methyltransferase|organism=Schmidtea mediterranea sexual|type=transcript|length=937bp
TAAAATTGAATGATAATTGGATTCAAAATGAATGATAATGAGTTAGTGTA
TTTTGTTGATGAGTCAGATATATGTATAAATGAAGTTGAAATATCTGACA
ATGAAAATATTGAAGTTACCGAGTTCTTTTCAAAAGACGAAGAAATATAC
GATATAATGCCAATAAAAGATGAACCTTATTTAAGTGAATCTACTGATGC
AATGACAGATTCAGATTATGAATCAAATAATTTATCTTTTGATGACAGTA
GAATTAAAGTGGAAAATGAGACATTTCGTGATATTAGTAATAATGGCAAA
GTCTCGCTTAGAACTCGTAAATCAATAACAAATAGTACCAGCACTACTAG
TTCAGAATCAAAACAACATGTTAAAGGGAATAAAAGAAAATTTAGCTCTA
GTACACAGGAAAATACTTCTGAAGAATACTATGTGGGCAGATTATTATGG
GCTAAAGTTAAATCCCATCCATGGTGGCCGTGTATGATATATTACAGTCC
AGAGAAAAATTTTTATAAAGAAATGTTCCATAAAAAAGTTATACATGTTG
CATATTTTGGTCCATATGTTCAGCGAGGTTGGGTTAGTATAAATAGTGTG
ATGTCATTTGAAGGAAAATTGAAATTTGATGATCACGTAAAGGAATTAAC
CGAGAACAATTCACCAAAAAATATAATACAGAAATATACCATTCCTCAAT
CCAGAATGAAAATTTTTTCTGAGTCATGGAAAGAAGCAGAAGAAGCAATG
ATGATGCCTGTAAAAGATCGAATCGATGTCTATGGAATATCTTATAAAAA
TCTAAATGGTGAATCGTCTTCTGAAAATGAGGAAAAAATCTCTGAAGAAG
AATTTGATGAATCAGACATGGATTCCTCGCCATGTAAAAAACAAAAAATA
GTTGCCGAAACTTTTGAATTCCAAAATTTAAAGTTGC
back to top

protein sequence of SMED30019720-orf-1

>SMED30019720-orf-1 ID=SMED30019720-orf-1|Name=SMED30019720-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=309bp
MIIGFKMNDNELVYFVDESDICINEVEISDNENIEVTEFFSKDEEIYDIM
PIKDEPYLSESTDAMTDSDYESNNLSFDDSRIKVENETFRDISNNGKVSL
RTRKSITNSTSTTSSESKQHVKGNKRKFSSSTQENTSEEYYVGRLLWAKV
KSHPWWPCMIYYSPEKNFYKEMFHKKVIHVAYFGPYVQRGWVSINSVMSF
EGKLKFDDHVKELTENNSPKNIIQKYTIPQSRMKIFSESWKEAEEAMMMP
VKDRIDVYGISYKNLNGESSSENEEKISEEEFDESDMDSSPCKKQKIVAE
TFEFQNLKL
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: molecular function
TermDefinition
GO:0018024histone-lysine N-methyltransferase activity
GO:0008168methyltransferase activity
GO:0008270zinc ion binding
GO:0016740transferase activity
GO:0046872metal ion binding
Vocabulary: biological process
TermDefinition
GO:0034968histone lysine methylation
GO:0032259methylation
Vocabulary: INTERPRO
TermDefinition
IPR042778ZCWPW1/ZCWPW2
IPR000313PWWP_dom
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000313PWWP domainSMARTSM00293PWWP_4coord: 139..200
e-value: 0.0022
score: 26.1
IPR000313PWWP domainPFAMPF00855PWWPcoord: 140..242
e-value: 5.3E-13
score: 49.2
IPR000313PWWP domainPROSITEPS50812PWWPcoord: 141..202
score: 13.386
NoneNo IPR availableGENE3DG3DSA:2.30.30.140coord: 116..260
e-value: 2.3E-23
score: 84.5
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 102..129
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 102..117
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 266..290
NoneNo IPR availableSUPERFAMILYSSF63748Tudor/PWWP/MBTcoord: 135..254
IPR042778Zinc finger CW-type PWWP domain protein ZCWPW1/ZCWPW2PANTHERPTHR15999UNCHARACTERIZEDcoord: 123..297