Doublesex and mab 3 transcription

Overview


Name	Doublesex and mab 3 transcription
Smed ID	SMED30019616
Length (bp)	1732

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Doublesex and mab 3 transcription (SMED30019616) t-SNE clustered cells

Violin plots show distribution of expression levels for Doublesex and mab 3 transcription (SMED30019616) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Doublesex and mab 3 transcription (SMED30019616) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Doublesex and mab 3 transcription (SMED30019616) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019616

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
nervous system	SMED30019616	SMESG000002896.1	dd_Smed_v4_14213_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30019616	SMESG000002896.1	dd_Smed_v4_14213_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30019616	SMESG000002896.1	dd_Smed_v4_14213_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cilated neuron	SMED30019616	SMESG000002896.1	dd_Smed_v4_14213_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019616	SMESG000002896.1	Contig46203	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019616	SMESG000002896.1	Contig46203	uc_Smed_v2	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Match: DMRTC2 (DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911])

HSP 1 Score: 59.3066 bits (142), Expect = 2.546e-9
Identity = 35/104 (33.65%), Postives = 57/104 (54.81%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDK 547
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ +
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQ 132

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Match: DMRTC2 (DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911])

HSP 1 Score: 57.7658 bits (138), Expect = 2.874e-9
Identity = 35/104 (33.65%), Postives = 57/104 (54.81%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDK 547
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ +
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQ 132

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Match: DMRTC2 (DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911])

HSP 1 Score: 57.7658 bits (138), Expect = 2.896e-9
Identity = 35/104 (33.65%), Postives = 57/104 (54.81%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDK 547
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ +
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQ 132

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Match: DMRTC2 (DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911])

HSP 1 Score: 60.8474 bits (146), Expect = 3.011e-9
Identity = 35/105 (33.33%), Postives = 57/105 (54.29%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKD 550
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ + 
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQP 133

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Match: DMRTC2 (DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:13911])

HSP 1 Score: 60.4622 bits (145), Expect = 4.528e-9
Identity = 35/104 (33.65%), Postives = 57/104 (54.81%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDK 547
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ +
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQ 132

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
Match: dmd-8 (DM (Doublesex/MAB-3) Domain family [Source:UniProtKB/TrEMBL;Acc:Q9TXN8])

HSP 1 Score: 77.7962 bits (190), Expect = 3.097e-15
Identity = 47/145 (32.41%), Postives = 71/145 (48.97%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQI 712
            C  CK HG  V  + H  TC Y  C+C +C LV + R++++ QI L R+Q      D+    T D   +S        T          ++  M   C++C+NHNV V  KNHKK C Y  C C  C LI+ R+  ++ ++  ++
Sbjct:   51 CGMCKQHGVFVETRGH--TCEYRSCECEQCDLVRKRREIMSTQIRLRREQ------DKKFQRTND---ISEANVFPGFTGGEADEKAVMENMNMCYFCQKCKNHNVLVWKKNHKKECQYSSCECQQCNLIDSRRALDRHIKKRKM 184

[Close]

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQI 712
            C  CK HG  V  + H  TC Y  C+C +C LV + R++++ QI L R+Q      D+    T D   +S        T          ++  M   C++C+NHNV V  KNHKK C Y  C C  C LI+ R+  ++ ++  ++
Sbjct:   51 CGMCKQHGVFVETRGH--TCEYRSCECEQCDLVRKRREIMSTQIRLRREQ------DKKFQRTND---ISEANVFPGFTGGEADEKAVMENMNMCYFCQKCKNHNVLVWKKNHKKECQYSSCECQQCNLIDSRRALDRHIKKRKM 184

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
Match: dmd-3 (DM (Doublesex/MAB-3) Domain family [Source:UniProtKB/TrEMBL;Acc:Q9XWN9])

HSP 1 Score: 71.2478 bits (173), Expect = 1.442e-13
Identity = 44/143 (30.77%), Postives = 74/143 (51.75%), Query Frame = 2

Query:  272 YMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVS---DKDAG----MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            Y C++C  HG     K HK +C +  C+C  C++V++ R++ ++ + +       G+ D     T    L   +E ++  T+ S  TN S   DKD G      P+C+RC  H+V    K HK++CP+R C C  C+++  R+
Sbjct:   17 YYCQRCLNHGLREKRKNHKLSCTFRFCQCSNCIMVERRRQLNSRLMQID------GSRDEKPMTTLTMALTCSEEDQMECTSQSETTNESSGEDKDDGKPKERRPNCQRCAQHSVVNRLKGHKRACPFRDCFCAKCQVVVERQ 153

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
Match: mab-3 (Protein male abnormal 3 [Source:UniProtKB/Swiss-Prot;Acc:O18214])

HSP 1 Score: 60.077 bits (144), Expect = 9.851e-10
Identity = 47/156 (30.13%), Postives = 68/156 (43.59%), Query Frame = 2

Query:  221 SESASAIGGDQ-AISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKS-CPYRHCPCDPCRLINVRKD 682
            SE   A   D+ A    +Y C++C  HG+L P K HK  C YL C C +C +V+Q R++                            L+S K+      TP+ +T   D      PHC RC  H V V  + HK++ C +  C C  C L+  R++
Sbjct:    8 SEICEAKAVDELAEQEKNYYCQRCLNHGELKPRKGHKPDCRYLKCPCRECTMVEQRRQL--------------------------NNLLSKKKIH---CTPATQTR--DGKRVRDPHCARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRN 132

HSP 2 Score: 51.9878 bits (123), Expect = 5.403e-7
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRT-CLYLHCKCIKCLLVDQGRKVVAKQIALYRDQR 430
            C +C  HG LVP++ HKRT C ++ C+C  C LV+  R ++A QI L R Q+
Sbjct:   94 CARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRNLMAAQIKLRRSQQ 145

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
Match: dmd-10 (DM (Doublesex/MAB-3) Domain family [Source:UniProtKB/TrEMBL;Acc:G5EEJ1])

HSP 1 Score: 52.373 bits (124), Expect = 3.290e-7
Identity = 22/52 (42.31%), Postives = 33/52 (63.46%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRH 433
            C+KC  HG+   +K HKR+C +  C C KC +V + +K++A QI + R QR 
Sbjct:   40 CQKCGQHGRKSRLKGHKRSCPFRECPCAKCAVVSERQKLMADQIKIRRRQRK 91

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Match: dmrt99B (gene:FBgn0039683 transcript:FBtr0085454)

HSP 1 Score: 54.299 bits (129), Expect = 2.111e-7
Identity = 23/59 (38.98%), Postives = 34/59 (57.63%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRH 454
            C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q     E R 
Sbjct:   41 CARCRNHGVVSALKGHKRYCRWRDCVCAKCTLIAERQRVMAAQVALRRQQAQEENEARE 99

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Match: dmrt93B (gene:FBgn0038851 transcript:FBtr0084007)

HSP 1 Score: 53.1434 bits (126), Expect = 3.344e-7
Identity = 20/50 (40.00%), Postives = 35/50 (70.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG +  ++ HK+ C Y +CKC KC+L+ + ++++A Q+AL R Q
Sbjct:   43 CARCRNHGIISELRGHKKLCTYKNCKCAKCVLIFERQRIMAAQVALKRQQ 92

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Match: dsx (gene:FBgn0000504 transcript:FBtr0339710)

HSP 1 Score: 49.2914 bits (116), Expect = 7.446e-6
Identity = 18/39 (46.15%), Postives = 26/39 (66.67%), Query Frame = 2

Query:  563 PHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            P+C RCRNH + +  K HK+ C +R+C C+ CRL   R+
Sbjct:   42 PNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLTADRQ 80

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Match: dsx (gene:FBgn0000504 transcript:FBtr0081761)

HSP 1 Score: 49.2914 bits (116), Expect = 7.446e-6
Identity = 18/39 (46.15%), Postives = 26/39 (66.67%), Query Frame = 2

Query:  563 PHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            P+C RCRNH + +  K HK+ C +R+C C+ CRL   R+
Sbjct:   42 PNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLTADRQ 80

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Match: dsx (gene:FBgn0000504 transcript:FBtr0081760)

HSP 1 Score: 49.2914 bits (116), Expect = 7.446e-6
Identity = 18/39 (46.15%), Postives = 26/39 (66.67%), Query Frame = 2

Query:  563 PHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            P+C RCRNH + +  K HK+ C +R+C C+ CRL   R+
Sbjct:   42 PNCARCRNHGLKITLKGHKRYCKFRYCTCEKCRLTADRQ 80

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Match: dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:402923])

HSP 1 Score: 55.0694 bits (131), Expect = 1.867e-8
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 2

Query:  245 GDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G  +I + S M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:    9 GSLSIRKPSRMPKCSRCRNHGFVSPLKGHKRFCNWRDCQCQKCRLIAERQRVMAAQVALRRQQ 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Match: dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:402923])

HSP 1 Score: 55.0694 bits (131), Expect = 1.922e-8
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 2

Query:  245 GDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G  +I + S M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:    9 GSLSIRKPSRMPKCSRCRNHGFVSPLKGHKRFCNWRDCQCQKCRLIAERQRVMAAQVALRRQQ 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Match: dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:402923])

HSP 1 Score: 55.0694 bits (131), Expect = 2.913e-8
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 2

Query:  245 GDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G  +I + S M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:    9 GSLSIRKPSRMPKCSRCRNHGFVSPLKGHKRFCNWRDCQCQKCRLIAERQRVMAAQVALRRQQ 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Match: dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:402923])

HSP 1 Score: 55.0694 bits (131), Expect = 2.978e-8
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 2

Query:  245 GDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G  +I + S M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:    9 GSLSIRKPSRMPKCSRCRNHGFVSPLKGHKRFCNWRDCQCQKCRLIAERQRVMAAQVALRRQQ 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Match: dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:402923])

HSP 1 Score: 55.8398 bits (133), Expect = 3.538e-8
Identity = 26/63 (41.27%), Postives = 40/63 (63.49%), Query Frame = 2

Query:  245 GDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G  +I + S M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:    9 GSLSIRKPSRMPKCSRCRNHGFVSPLKGHKRFCNWRDCQCQKCRLIAERQRVMAAQVALRRQQ 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Match: DMRT1 (doublesex and mab-3 related transcription factor 1 [Source:NCBI gene;Acc:100488257])

HSP 1 Score: 56.225 bits (134), Expect = 6.079e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG   P+K HKR C++  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   32 CARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQ 81

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Match: kdm2b (lysine (K)-specific demethylase 2B [Source:Xenbase;Acc:XB-GENE-990506])

HSP 1 Score: 56.9954 bits (136), Expect = 6.322e-8
Identity = 29/76 (38.16%), Postives = 45/76 (59.21%), Query Frame = 2

Query:  224 ESASAIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            + A+  GG+Q     +  C +C+ HG +  +K HKR C +  C+C  CLLV + ++V+A Q+AL R Q    TED+
Sbjct:   79 QKANEKGGEQRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQ---ATEDK 151

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Match: dmrta1 (DMRT like family A1 [Source:NCBI gene;Acc:779901])

HSP 1 Score: 53.5286 bits (127), Expect = 6.061e-7
Identity = 25/70 (35.71%), Postives = 38/70 (54.29%), Query Frame = 2

Query:  242 GGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            G   A+   +  C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q     E R
Sbjct:   71 GSGNALYPRTPKCARCRNHGVVSALKGHKRFCRWRDCSCAKCTLIAERQRVMAAQVALRRQQAQEECEVR 140

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Match: dynll1 (dynein light chain LC8-type 1 [Source:Xenbase;Acc:XB-GENE-854521])

HSP 1 Score: 52.7582 bits (125), Expect = 1.047e-6
Identity = 23/59 (38.98%), Postives = 34/59 (57.63%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRH 454
            C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q     E R 
Sbjct:   49 CARCRNHGVVSALKGHKRYCRWKDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEARE 107

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Match: st3gal4 (ST3 beta-galactoside alpha-2,3-sialyltransferase 4 [Source:Xenbase;Acc:XB-GENE-963280])

HSP 1 Score: 52.373 bits (124), Expect = 1.320e-6
Identity = 26/67 (38.81%), Postives = 39/67 (58.21%), Query Frame = 2

Query:  239 IGGDQAISRASYM----CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            +GG  +  RA       C +C+ HG L  +K HKR C +  C C KC+L+ + ++V+A Q+AL R Q
Sbjct:   11 MGGPVSQPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQ 77

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Match: Dmrtc2 (doublesex and mab-3 related transcription factor like family C2 [Source:MGI Symbol;Acc:MGI:1918491])

HSP 1 Score: 59.6918 bits (143), Expect = 3.834e-9
Identity = 35/105 (33.33%), Postives = 57/105 (54.29%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKD 550
            + +SR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     RH+  +      T  +  +  K+  +R   PS K N++ + 
Sbjct:   34 RPVSR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLA-QGLMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQP 136

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Match: Dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:MGI Symbol;Acc:MGI:1354733])

HSP 1 Score: 57.7658 bits (138), Expect = 1.872e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG   P+K HKR C++  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   74 CARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQ 123

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Match: Dmrt1 (doublesex and mab-3 related transcription factor 1 [Source:MGI Symbol;Acc:MGI:1354733])

HSP 1 Score: 54.6842 bits (130), Expect = 8.024e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG   P+K HKR C++  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   74 CARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQ 123

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Match: Dmrta1 (doublesex and mab-3 related transcription factor like family A1 [Source:MGI Symbol;Acc:MGI:2653627])

HSP 1 Score: 54.6842 bits (130), Expect = 2.582e-7
Identity = 23/58 (39.66%), Postives = 35/58 (60.34%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q    +E R
Sbjct:   86 CARCRNHGVVSALKGHKRFCRWRDCACAKCTLIAERQRVMAAQVALRRQQAQEESEAR 143

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Match: Dmrt2 (doublesex and mab-3 related transcription factor 2 [Source:MGI Symbol;Acc:MGI:1330307])

HSP 1 Score: 53.9138 bits (128), Expect = 3.987e-7
Identity = 31/76 (40.79%), Postives = 46/76 (60.53%), Query Frame = 2

Query:  230 ASAIGGDQA--ISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            A+A GG +   +SR    C +C+ HG +  +K HKR C +  C+C  CLLV + ++V+A Q+AL R Q    TED+
Sbjct:  106 ATAGGGAEPRKLSRTP-KCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQ---ATEDK 177

[Close]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Match: sp|Q9XWN9|DMD3_CAEEL (Doublesex- and mab-3-related transcription factor dmd-3 OS=Caenorhabditis elegans OX=6239 GN=dmd-3 PE=2 SV=2)

HSP 1 Score: 71.2478 bits (173), Expect = 1.834e-12
Identity = 44/143 (30.77%), Postives = 74/143 (51.75%), Query Frame = 2

Query:  272 YMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVS---DKDAG----MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            Y C++C  HG     K HK +C +  C+C  C++V++ R++ ++ + +       G+ D     T    L   +E ++  T+ S  TN S   DKD G      P+C+RC  H+V    K HK++CP+R C C  C+++  R+
Sbjct:   17 YYCQRCLNHGLREKRKNHKLSCTFRFCQCSNCIMVERRRQLNSRLMQID------GSRDEKPMTTLTMALTCSEEDQMECTSQSETTNESSGEDKDDGKPKERRPNCQRCAQHSVVNRLKGHKRACPFRDCFCAKCQVVVERQ 153

[Close]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Match: sp|O18214|MAB3_CAEEL (Protein male abnormal 3 OS=Caenorhabditis elegans OX=6239 GN=mab-3 PE=1 SV=1)

HSP 1 Score: 60.077 bits (144), Expect = 1.253e-8
Identity = 47/156 (30.13%), Postives = 68/156 (43.59%), Query Frame = 2

Query:  221 SESASAIGGDQ-AISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKS-CPYRHCPCDPCRLINVRKD 682
            SE   A   D+ A    +Y C++C  HG+L P K HK  C YL C C +C +V+Q R++                            L+S K+      TP+ +T   D      PHC RC  H V V  + HK++ C +  C C  C L+  R++
Sbjct:    8 SEICEAKAVDELAEQEKNYYCQRCLNHGELKPRKGHKPDCRYLKCPCRECTMVEQRRQL--------------------------NNLLSKKKIH---CTPATQTR--DGKRVRDPHCARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRN 132

HSP 2 Score: 51.9878 bits (123), Expect = 6.873e-6
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRT-CLYLHCKCIKCLLVDQGRKVVAKQIALYRDQR 430
            C +C  HG LVP++ HKRT C ++ C+C  C LV+  R ++A QI L R Q+
Sbjct:   94 CARCSAHGVLVPLRGHKRTMCQFVTCECTLCTLVEHRRNLMAAQIKLRRSQQ 145

[Close]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Match: sp|Q8IXT2|DMRTD_HUMAN (Doublesex- and mab-3-related transcription factor C2 OS=Homo sapiens OX=9606 GN=DMRTC2 PE=2 SV=2)

HSP 1 Score: 60.8474 bits (146), Expect = 1.446e-8
Identity = 35/105 (33.33%), Postives = 57/105 (54.29%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKD 550
            +AISR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     +H+      S +  +     F++   +   PS K N++ + 
Sbjct:   34 RAISR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKKHLMRRGEASPKAPNH----FRKGTTQPQVPSGKENIAPQP 133

[Close]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Match: sp|Q8CGW9|DMRTD_MOUSE (Doublesex- and mab-3-related transcription factor C2 OS=Mus musculus OX=10090 GN=Dmrtc2 PE=2 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 2.682e-8
Identity = 35/105 (33.33%), Postives = 57/105 (54.29%), Query Frame = 2

Query:  251 QAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ-----RHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKD 550
            + +SR S  C +C+ HG    +K HKR CL+  C+C KC+L+ + R+V+A Q+AL R Q     RH+  +      T  +  +  K+  +R   PS K N++ + 
Sbjct:   34 RPVSR-SPTCARCRNHGVTAHLKGHKRLCLFQACECHKCVLILERRRVMAAQVALRRQQEAQLKRHLA-QGLMKGATPLKAPLRVKKGAIRPGIPSGKENIAPQP 136

[Close]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Match: sp|B0I1G7|DMW_XENLA (Doublesex- and mab-3-related transcription factor DM-W OS=Xenopus laevis OX=8355 GN=dm-w PE=1 SV=1)

HSP 1 Score: 55.4546 bits (132), Expect = 1.424e-7
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG   P+K HKR C++  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   28 CARCRNHGYATPLKGHKRFCIWRDCQCQKCSLITERQRVIAAQVALQRQQ 77

[Close]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Match: A0A068WUE5 (Doublesex and mab 3 transcription OS=Echinococcus granulosus OX=6210 GN=EgrG_000712700 PE=4 SV=1)

HSP 1 Score: 208.379 bits (529), Expect = 3.935e-54
Identity = 107/188 (56.91%), Postives = 123/188 (65.43%), Query Frame = 2

Query:  257 ISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIG------TEDRHSSETQDQ----RLVSFK-----------EYRLRGT-------TPSVKTNVSDKDAG---MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADES 727
            +SRASYMCRKCK HG+ VPVKRHKR C YL C+C+KC LVDQGRKVVA+QIALYRDQ+         T   HS  ++D+    RL   +           E R+ G        TPSVK +      G    GPHCRRCRNHNV V WK HKKSCPYR+CPCDPCRLINVRKDTEKTLRDM  + ++S
Sbjct:  248 VSRASYMCRKCKAHGQAVPVKRHKRACPYLQCRCLKCRLVDQGRKVVARQIALYRDQKGHSGGSSGSTNTTHSRGSRDEHSRPRLAGLRPNTLLQLPLPRELRIDGARVLPSLMTPSVKVDGQALIGGRTVAGPHCRRCRNHNVAVTWKGHKKSCPYRNCPCDPCRLINVRKDTEKTLRDMAGIEEKS 435

[Close]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Match: A0A158R6J0 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS317 PE=4 SV=1)

HSP 1 Score: 207.994 bits (528), Expect = 6.945e-54
Identity = 108/187 (57.75%), Postives = 122/187 (65.24%), Query Frame = 2

Query:  260 SRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQR-HIG-----TEDRHSSETQDQ----RLVSFK-----------EYRLRGT-------TPSVKTNVSDKDAG---MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADES 727
            SRASYMCRKCK HG+ VPVKRHKR C YL C+C+KC LVDQGRKVVA+QIALYRDQ+ H G         HS  ++D     RL S +           E R+ G         P+VK N      G    GPHCRRCRNHNV V WK HKKSCPYR+CPCDPCRLINVRKDTEKTLRDM  + ++S
Sbjct:  257 SRASYMCRKCKAHGQAVPVKRHKRACPYLQCRCLKCRLVDQGRKVVARQIALYRDQKGHSGGSGGPANATHSRASRDDSSRPRLASLRSNPLIQLPLPRELRIDGARVLPSLMVPTVKVNGQTLIGGRTVAGPHCRRCRNHNVAVTWKGHKKSCPYRNCPCDPCRLINVRKDTEKTLRDMAGIEEKS 443

[Close]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Match: A0A0R3TWW3 (Uncharacterized protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS12336 PE=4 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 2.262e-53
Identity = 113/217 (52.07%), Postives = 130/217 (59.91%), Query Frame = 2

Query:  200 SNVYQQGSESAS----AIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQR-HIGT----------EDRHSSETQD--QRLVSF-----------KEYRLRG--------TTPSVKTNVSDKD-----AGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADES 727
            S+    G ESAS    A  G   +SRASYMCRKCK HG+ VPVKRHKR C YL C+C+KC LVDQGRKVVA+QIALYRDQ+ H G             RHS +      RL              +E RL           +PS K   +        + +GPHCRRCRNHNV V WK HKKSCPYR+CPCDPCRLINVRKDTEKTLRDM  + ++S
Sbjct:  170 SSTEDNGKESASGDLEAGSGSAVVSRASYMCRKCKAHGQAVPVKRHKRACPYLQCRCLKCRLVDQGRKVVARQIALYRDQKGHSGNFGGSSSNSRGNPRHSRDDNASYSRLTGLRSNPLLQLPFPRELRLDENRILPSLMNSPSAKVGPNSAPLIPGRSVVGPHCRRCRNHNVAVTWKGHKKSCPYRNCPCDPCRLINVRKDTEKTLRDMAGIEEKS 386

[Close]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Match: A0A068YBA1 (Doublesex and mab 3 transcription OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000712700 PE=4 SV=1)

HSP 1 Score: 205.682 bits (522), Expect = 4.214e-53
Identity = 107/188 (56.91%), Postives = 123/188 (65.43%), Query Frame = 2

Query:  257 ISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIG------TEDRHSSETQDQ----RLVSFKEY-----------RLRGT-------TPSVKTNVSDKDAG---MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADES 727
            +SRASYMCRKCK HG+ VPVKRHKR C YL C+C+KC LVDQGRKVVA+QIALYRDQ+         T   HS  ++D+    RL S +             R+ G        TPSVK +      G    GPHCRRCRNHNV V WK HKKSCPYR+CPCDPCRLINVRKDTEKTLRDM  + ++S
Sbjct:  261 VSRASYMCRKCKAHGQAVPVKRHKRACPYLQCRCLKCRLVDQGRKVVARQIALYRDQKGHSGGSSGSTNTTHSRGSRDEHSRPRLASLRPNPPLQLPLPRELRIDGARVLPSLMTPSVKVDGQALIGGRTVAGPHCRRCRNHNVAVTWKGHKKSCPYRNCPCDPCRLINVRKDTEKTLRDMAGIEEKS 448

[Close]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Match: A0A564Z380 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS12066 PE=4 SV=1)

HSP 1 Score: 205.297 bits (521), Expect = 4.649e-53
Identity = 113/217 (52.07%), Postives = 131/217 (60.37%), Query Frame = 2

Query:  200 SNVYQQGSESASA---IG-GDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQR-HIGT----------EDRHSSE--TQDQRLVSFK-----------EYRL--RGTTPSVKTNVSDKDAG-----------MGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADES 727
            S+    G E+AS    +G G   +SRASYMCRKCK HG+ VPVKRHKR C YL C+C+KC LV+QGRKVVA+QIALYRDQ+ H G             RHS +  +   RL   +           E RL      PS+  N S K               GPHCRRCRNHNV V WK HKKSCPYR+CPCDPCRLINVRKDTEKTLRDM  + ++S
Sbjct:  170 SSTEDNGKEAASGDMEVGSGSAVVSRASYMCRKCKAHGQAVPVKRHKRACPYLQCRCLKCRLVEQGRKVVARQIALYRDQKGHSGNFGGNNTNPCGNSRHSRDDNSSHSRLTGLRSNPLLQLPFPRELRLDENRILPSLMNNPSVKVGQNSALLMPGRNVAGPHCRRCRNHNVAVTWKGHKKSCPYRNCPCDPCRLINVRKDTEKTLRDMAGIEEKS 386

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Match: dmrt1 (doublesex- and mab-3-related transcription factor 1 [Source:NCBI gene;Acc:103041212])

HSP 1 Score: 55.8398 bits (133), Expect = 3.901e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   34 CSRCRNHGFVSPLKGHKRFCNWRDCQCQKCKLISERQRVMAAQVALRRQQ 83

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Match: dmrt2a (doublesex- and mab-3-related transcription factor 2 [Source:NCBI gene;Acc:103040902])

HSP 1 Score: 55.0694 bits (131), Expect = 1.236e-7
Identity = 27/71 (38.03%), Postives = 42/71 (59.15%), Query Frame = 2

Query:  239 IGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            + G+Q     +  C +C+ HG +  +K HKR C +  C+C  CLLV + ++V+A Q+AL R Q    TED+
Sbjct:   52 MSGEQKKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQ---ATEDK 119

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Match: DMRTA1 (doublesex- and mab-3-related transcription factor A2 [Source:NCBI gene;Acc:103021351])

HSP 1 Score: 54.6842 bits (130), Expect = 1.287e-7
Identity = 21/52 (40.38%), Postives = 32/52 (61.54%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRH 433
            C +C+ HG L  +K HKR C +  C C +C L+ + ++V+A Q+AL R Q  
Sbjct:   34 CARCRNHGVLSALKGHKRACRWRECACARCALIAERQRVMAAQVALRRQQEQ 85

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Match: dmrt3a (doublesex and mab-3 related transcription factor 3 [Source:NCBI gene;Acc:103040280])

HSP 1 Score: 55.0694 bits (131), Expect = 1.324e-7
Identity = 27/67 (40.30%), Postives = 40/67 (59.70%), Query Frame = 2

Query:  239 IGGDQAISRASYM----CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            +GG  A +RA       C +C+ HG L  +K HKR C +  C C KC+L+ + ++V+A Q+AL R Q
Sbjct:   11 VGGPVAQARAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCDKCILIIERQRVMAAQVALRRQQ 77

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Match: dmrta2 (DMRT like family A2 [Source:NCBI gene;Acc:103023395])

HSP 1 Score: 54.6842 bits (130), Expect = 1.591e-7
Identity = 23/59 (38.98%), Postives = 34/59 (57.63%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRH 454
            C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q     E R 
Sbjct:   63 CARCRNHGVVSALKGHKRYCRWKDCMCAKCTLIAERQRVMAAQVALRRQQAQEENEARE 121

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004009.1 (pep scaffold:Pmarinus_7.0:GL483432:15080:15595:1 gene:ENSPMAG00000003668.1 transcript:ENSPMAT00000004009.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.0618 bits (118), Expect = 9.539e-8
Identity = 23/59 (38.98%), Postives = 35/59 (59.32%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRH 454
            C +C+ HG +  +K HKR C +  C C KC L+ + ++V+A Q+AL R Q    +E R 
Sbjct:   54 CARCRNHGVVSALKGHKRYCRWRDCLCAKCTLIAERQRVMAAQVALRRQQAQEESEVRE 112

HSP 2 Score: 45.4394 bits (106), Expect = 4.860e-6
Identity = 24/58 (41.38%), Postives = 29/58 (50.00%), Query Frame = 2

Query:  506 RGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            RG   S+    +DK     P C RCRNH V    K HK+ C +R C C  C LI  R+
Sbjct:   34 RGPPHSLLLRAADKYQRT-PKCARCRNHGVVSALKGHKRYCRWRDCLCAKCTLIAERQ 90

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Sea Lamprey
Match: dmrt2b (doublesex and mab-3 related transcription factor 2b [Source:ZFIN;Acc:ZDB-GENE-080813-1])

HSP 1 Score: 46.595 bits (109), Expect = 5.400e-6
Identity = 22/50 (44.00%), Postives = 33/50 (66.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG +  +K HKR C +  C+C  CLLV + ++V+A Q+AL R Q
Sbjct:   54 CARCRNHG-VSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQ 102

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Match: EDO30270 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T198])

HSP 1 Score: 49.2914 bits (116), Expect = 6.102e-8
Identity = 29/69 (42.03%), Postives = 44/69 (63.77%), Query Frame = 2

Query:  221 SESASAIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            SESAS   GD+ + R S  C +C+ HG +  +K HKR C +  C C KC L+ + ++++A Q+AL RD+
Sbjct:    2 SESAS---GDENLIR-SPRCARCRNHGIVSYLKGHKRYCQWKDCTCTKCSLIIERQRLMAAQVALKRDE 66

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Match: EDO37386 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFT8])

HSP 1 Score: 47.7506 bits (112), Expect = 1.324e-7
Identity = 20/50 (40.00%), Postives = 31/50 (62.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG L  +K HK  C +  C C KCLL+ + +++ A ++AL R Q
Sbjct:    5 CARCRNHGALSWLKGHKHYCRWRDCTCSKCLLIAERQRITAARVALLRQQ 54

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Match: EDO42568 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S128])

HSP 1 Score: 47.3654 bits (111), Expect = 2.162e-7
Identity = 20/50 (40.00%), Postives = 32/50 (64.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG L  ++ HK  C +  C C +C++V + +K+ A +IALYR Q
Sbjct:    5 CTRCRNHGILSDLRGHKHQCRFKDCACNECMIVAERQKLTAARIALYRQQ 54

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Match: EDO34491 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SP73])

HSP 1 Score: 50.8322 bits (120), Expect = 5.169e-7
Identity = 26/67 (38.81%), Postives = 36/67 (53.73%), Query Frame = 2

Query:  536 VSDKDAGMGPHCRRCRNHNVTVI-WKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDM---QIVADE 724
             +  DA   P C RCRNH V  +  K H K CP++ C CD C LI  R +T +    M   +++A+E
Sbjct:    5 ATKSDAPKPPTCTRCRNHFVWFVPLKGHSKVCPWKTCECDKCILIKQRGETNRKRSGMTTSKVIAEE 71

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Match: EDO27141 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SV98])

HSP 1 Score: 46.2098 bits (108), Expect = 6.527e-7
Identity = 19/39 (48.72%), Postives = 23/39 (58.97%), Query Frame = 2

Query:  563 PHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRK 679
            P C RCRNH V  I K HK+ C ++ C C  C LI  R+
Sbjct:    3 PKCARCRNHGVISILKGHKRFCKWKDCTCPDCNLIAERQ 41

HSP 2 Score: 45.0542 bits (105), Expect = 1.518e-6
Identity = 20/50 (40.00%), Postives = 31/50 (62.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG +  +K HKR C +  C C  C L+ + ++V+A Q+AL R Q
Sbjct:    5 CARCRNHGVISILKGHKRFCKWKDCTCPDCNLIAERQRVMAAQVALRRQQ 54

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Match: dmy (Oryzias latipes doublesex- and mab-3-related transcription factor 1 (dmy), mRNA. [Source:RefSeq mRNA;Acc:NM_001104680])

HSP 1 Score: 54.299 bits (129), Expect = 1.992e-8
Identity = 26/64 (40.62%), Postives = 39/64 (60.94%), Query Frame = 2

Query:  242 GGDQAISRASYM--CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            G   A  R+  M  C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   13 GPAPAPQRSPRMPKCSRCRNHGFVSPLKGHKRFCRWKDCRCAKCKLIAERQRVMAAQVALRRQQ 76

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Match: dmrt2a (doublesex- and mab-3-related transcription factor 2 [Source:NCBI gene;Acc:101163154])

HSP 1 Score: 57.7658 bits (138), Expect = 2.077e-8
Identity = 29/70 (41.43%), Postives = 42/70 (60.00%), Query Frame = 2

Query:  242 GGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDR 451
            GGDQ     +  C +C+ HG +  +K HKR C +  C+C  CLLV + ++V+A Q+AL R Q    TED+
Sbjct:   71 GGDQRKLSRTPKCARCRNHGVVSCLKGHKRFCRWRDCQCANCLLVVERQRVMAAQVALRRQQ---ATEDK 137

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Match: dmy (Oryzias latipes doublesex- and mab-3-related transcription factor 1 (dmy), mRNA. [Source:RefSeq mRNA;Acc:NM_001104680])

HSP 1 Score: 55.4546 bits (132), Expect = 4.807e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   27 CSRCRNHGFVSPLKGHKRFCRWKDCRCAKCKLIAERQRVMAAQVALRRQQ 76

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Match: dmy (Oryzias latipes doublesex- and mab-3-related transcription factor 1 (dmy), mRNA. [Source:RefSeq mRNA;Acc:NM_001104680])

HSP 1 Score: 55.4546 bits (132), Expect = 4.871e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   27 CSRCRNHGFVSPLKGHKRFCRWKDCRCAKCKLIAERQRVMAAQVALRRQQ 76

[Close]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Match: dmy (Oryzias latipes doublesex- and mab-3-related transcription factor 1 (dmy), mRNA. [Source:RefSeq mRNA;Acc:NM_001104680])

HSP 1 Score: 55.4546 bits (132), Expect = 4.920e-8
Identity = 22/50 (44.00%), Postives = 34/50 (68.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG + P+K HKR C +  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   17 CSRCRNHGFVSPLKGHKRFCRWKDCRCAKCKLIAERQRVMAAQVALRRQQ 66

[Close]

BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST
Match: SMESG000002896.1 (SMESG000002896.1)

HSP 1 Score: 789.26 bits (2037), Expect = 0.000e+0
Identity = 395/396 (99.75%), Postives = 395/396 (99.75%), Query Frame = 2

Query:  158 MKLETIVRPDLSQLSNVYQQGSESASAIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADESNCSSRSKNSYHTYPGYSQTTVPSKSPNAVYNPMMDKPNFDLXXXXXXXXXXXXXXXLLGPGINSTFQKLVSATCPGSTAGDLSHLANISSQFNNTDLFTNNSDIASTVPFKSLGGGFMINNRNPTNYQSLDYHPEMWTYLNPSRSTAFSYYGMGGEYCNPTYSYLNSLGMANHDTPQTPLVPMSDHSDQDASSGSTMYRSFTDYCY 1345
            MKLETIVRPDLSQLSNVYQQGSESASAIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTT SVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADESNCSSRSKNSYHTYPGYSQTTVPSKSPNAVYNPMMDKPNFDLYPRSSISNYYNSSPNLLGPGINSTFQKLVSATCPGSTAGDLSHLANISSQFNNTDLFTNNSDIASTVPFKSLGGGFMINNRNPTNYQSLDYHPEMWTYLNPSRSTAFSYYGMGGEYCNPTYSYLNSLGMANHDTPQTPLVPMSDHSDQDASSGSTMYRSFTDYCY
Sbjct:    1 MKLETIVRPDLSQLSNVYQQGSESASAIGGDQAISRASYMCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTASVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADESNCSSRSKNSYHTYPGYSQTTVPSKSPNAVYNPMMDKPNFDLYPRSSISNYYNSSPNLLGPGINSTFQKLVSATCPGSTAGDLSHLANISSQFNNTDLFTNNSDIASTVPFKSLGGGFMINNRNPTNYQSLDYHPEMWTYLNPSRSTAFSYYGMGGEYCNPTYSYLNSLGMANHDTPQTPLVPMSDHSDQDASSGSTMYRSFTDYCY 396

[Close]

BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST
Match: SMESG000080385.1 (SMESG000080385.1)

HSP 1 Score: 110.923 bits (276), Expect = 1.211e-26
Identity = 56/144 (38.89%), Postives = 74/144 (51.39%), Query Frame = 2

Query:  275 MCRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIWKNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDM 706
            MCRKC+ HG+L+PVK H+R C +  C C  C +V  GR++VA+QI LYR+Q+ I                                    K +   PHCRRCRNH     WK HKK C + +CPC  C LI +RK  EK+ R++
Sbjct:   58 MCRKCRAHGQLLPVKNHRRNCPFKLCPCPLCTVVSHGREIVARQIRLYRNQKDIS-----------------------------------KRSPQSPHCRRCRNHGEHNAWKGHKKKCRHSNCPCKLCLLITMRKTNEKSYREI 166

[Close]

BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST
Match: SMESG000075920.1 (SMESG000075920.1)

HSP 1 Score: 56.225 bits (134), Expect = 3.321e-8
Identity = 30/89 (33.71%), Postives = 45/89 (50.56%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHSSETQDQRLVSFKEYRLRGTTPSVKTNVSD 544
            C +C+ HG + P+K HKR C +  C C KC L+ + ++V+A Q+AL R Q     E       Q++ +V           P  K N+SD
Sbjct:   54 CARCRNHGYVSPLKGHKRYCRWKDCVCAKCALIAERQRVMAAQVALRRQQAQEEQEINDFVMYQNEEIV---------YPPDSKKNISD 133

[Close]

BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST
Match: SMESG000006521.1 (SMESG000006521.1)

HSP 1 Score: 53.9138 bits (128), Expect = 2.414e-7
Identity = 22/50 (44.00%), Postives = 33/50 (66.00%), Query Frame = 2

Query:  278 CRKCKVHGKLVPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQ 427
            C +C+ HG +  +K HKR C Y  C+C KC L+ + ++V+A Q+AL R Q
Sbjct:   44 CARCRNHGMVSWLKGHKRHCHYKDCRCAKCNLIAERQRVMAAQVALKRQQ 93

The following BLAST results are available for this feature:

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
BLAST of Doublesex and mab 3 transcription vs. TrEMBL
BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
BLAST of Doublesex and mab 3 transcription vs. Ensembl Sea Lamprey
BLAST of Doublesex and mab 3 transcription vs. Ensembl Yeast
BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST

BLAST of Doublesex and mab 3 transcription vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DMRTC2	2.546e-9	33.65	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:1...	[more]
DMRTC2	2.874e-9	33.65	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:1...	[more]
DMRTC2	2.896e-9	33.65	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:1...	[more]
DMRTC2	3.011e-9	33.33	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:1...	[more]
DMRTC2	4.528e-9	33.65	DMRT like family C2 [Source:HGNC Symbol;Acc:HGNC:1...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmd-8	3.097e-15	32.41	DM (Doublesex/MAB-3) Domain family [Source:UniPro...	[more]
dmd-8	3.097e-15	32.41	DM (Doublesex/MAB-3) Domain family [Source:UniPro...	[more]
dmd-3	1.442e-13	30.77	DM (Doublesex/MAB-3) Domain family [Source:UniPro...	[more]
mab-3	9.851e-10	30.13	Protein male abnormal 3 [Source:UniProtKB/Swiss-P...	[more]
dmd-10	3.290e-7	42.31	DM (Doublesex/MAB-3) Domain family [Source:UniPro...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmrt99B	2.111e-7	38.98	gene:FBgn0039683 transcript:FBtr0085454	[more]
dmrt93B	3.344e-7	40.00	gene:FBgn0038851 transcript:FBtr0084007	[more]
dsx	7.446e-6	46.15	gene:FBgn0000504 transcript:FBtr0339710	[more]
dsx	7.446e-6	46.15	gene:FBgn0000504 transcript:FBtr0081761	[more]
dsx	7.446e-6	46.15	gene:FBgn0000504 transcript:FBtr0081760	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmrt1	1.867e-8	41.27	doublesex and mab-3 related transcription factor 1...	[more]
dmrt1	1.922e-8	41.27	doublesex and mab-3 related transcription factor 1...	[more]
dmrt1	2.913e-8	41.27	doublesex and mab-3 related transcription factor 1...	[more]
dmrt1	2.978e-8	41.27	doublesex and mab-3 related transcription factor 1...	[more]
dmrt1	3.538e-8	41.27	doublesex and mab-3 related transcription factor 1...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
DMRT1	6.079e-8	44.00	doublesex and mab-3 related transcription factor 1...	[more]
kdm2b	6.322e-8	38.16	lysine (K)-specific demethylase 2B [Source:Xenbase...	[more]
dmrta1	6.061e-7	35.71	DMRT like family A1 [Source:NCBI gene;Acc:779901]	[more]
dynll1	1.047e-6	38.98	dynein light chain LC8-type 1 [Source:Xenbase;Acc:...	[more]
st3gal4	1.320e-6	38.81	ST3 beta-galactoside alpha-2,3-sialyltransferase 4...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Dmrtc2	3.834e-9	33.33	doublesex and mab-3 related transcription factor l...	[more]
Dmrt1	1.872e-8	44.00	doublesex and mab-3 related transcription factor 1...	[more]
Dmrt1	8.024e-8	44.00	doublesex and mab-3 related transcription factor 1...	[more]
Dmrta1	2.582e-7	39.66	doublesex and mab-3 related transcription factor l...	[more]
Dmrt2	3.987e-7	40.79	doublesex and mab-3 related transcription factor 2...	[more]

BLAST of Doublesex and mab 3 transcription vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q9XWN9\|DMD3_CAEEL	1.834e-12	30.77	Doublesex- and mab-3-related transcription factor ...	[more]
sp\|O18214\|MAB3_CAEEL	1.253e-8	30.13	Protein male abnormal 3 OS=Caenorhabditis elegans ...	[more]
sp\|Q8IXT2\|DMRTD_HUMAN	1.446e-8	33.33	Doublesex- and mab-3-related transcription factor ...	[more]
sp\|Q8CGW9\|DMRTD_MOUSE	2.682e-8	33.33	Doublesex- and mab-3-related transcription factor ...	[more]
sp\|B0I1G7\|DMW_XENLA	1.424e-7	44.00	Doublesex- and mab-3-related transcription factor ...	[more]

BLAST of Doublesex and mab 3 transcription vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A068WUE5	3.935e-54	56.91	Doublesex and mab 3 transcription OS=Echinococcus ...	[more]
A0A158R6J0	6.945e-54	57.75	Uncharacterized protein OS=Taenia asiatica OX=6051...	[more]
A0A0R3TWW3	2.262e-53	52.07	Uncharacterized protein OS=Rodentolepis nana OX=10...	[more]
A0A068YBA1	4.214e-53	56.91	Doublesex and mab 3 transcription OS=Echinococcus ...	[more]
A0A564Z380	4.649e-53	52.07	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmrt1	3.901e-8	44.00	doublesex- and mab-3-related transcription factor ...	[more]
dmrt2a	1.236e-7	38.03	doublesex- and mab-3-related transcription factor ...	[more]
DMRTA1	1.287e-7	40.38	doublesex- and mab-3-related transcription factor ...	[more]
dmrt3a	1.324e-7	40.30	doublesex and mab-3 related transcription factor 3...	[more]
dmrta2	1.591e-7	38.98	DMRT like family A2 [Source:NCBI gene;Acc:10302339...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000004009.1	9.539e-8	38.98	pep scaffold:Pmarinus_7.0:GL483432:15080:15595:1 g...	[more]
dmrt2b	5.400e-6	44.00	doublesex and mab-3 related transcription factor 2...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Doublesex and mab 3 transcription vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO30270	6.102e-8	42.03	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO37386	1.324e-7	40.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO42568	2.162e-7	40.00	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34491	5.169e-7	38.81	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27141	6.527e-7	48.72	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Doublesex and mab 3 transcription vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
dmy	1.992e-8	40.63	Oryzias latipes doublesex- and mab-3-related trans...	[more]
dmrt2a	2.077e-8	41.43	doublesex- and mab-3-related transcription factor ...	[more]
dmy	4.807e-8	44.00	Oryzias latipes doublesex- and mab-3-related trans...	[more]
dmy	4.871e-8	44.00	Oryzias latipes doublesex- and mab-3-related trans...	[more]
dmy	4.920e-8	44.00	Oryzias latipes doublesex- and mab-3-related trans...	[more]

BLAST of Doublesex and mab 3 transcription vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 4


Match Name	E-value	Identity	Description
SMESG000002896.1	0.000e+0	99.75	SMESG000002896.1	[more]
SMESG000080385.1	1.211e-26	38.89	SMESG000080385.1	[more]
SMESG000075920.1	3.321e-8	33.71	SMESG000075920.1	[more]
SMESG000006521.1	2.414e-7	44.00	SMESG000006521.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019616 ID=SMED30019616|Name=Doublesex and mab 3 transcription|organism=Schmidtea mediterranea sexual|type=transcript|length=1732bp
TACACTGTCACTAGGAACAAGAAACCGGTCCGAATAGTAGCAGTTGAGAG
TTATTAATGATCCATCGATTCAATAGTAATTATCAGACCAAGTTGAGTTC
CAGCACTGTTTCGTAACAAAGTAACGATCATTTATAACAAAAATTCGACG
TAGCACAATGAAGTTAGAAACAATCGTTAGACCAGATTTGTCTCAATTGT
CCAATGTTTACCAACAGGGTTCAGAATCTGCCAGCGCTATTGGCGGAGAT
CAAGCCATATCAAGGGCATCGTACATGTGCAGAAAATGTAAAGTCCATGG
AAAATTAGTTCCGGTTAAGAGACACAAAAGAACCTGTTTATACTTGCACT
GCAAATGCATCAAATGCCTCTTAGTAGATCAAGGCAGAAAGGTTGTAGCA
AAACAAATTGCACTTTATCGAGACCAGAGACACATTGGAACCGAAGACCG
ACACAGCAGTGAAACTCAAGATCAGAGACTCGTCAGTTTCAAGGAGTATC
GACTTAGAGGAACAACACCGTCAGTTAAGACCAATGTATCCGACAAAGAT
GCTGGAATGGGTCCACATTGTCGTCGATGCAGGAATCACAATGTCACTGT
GATATGGAAGAATCATAAAAAATCATGTCCATATCGTCATTGCCCATGTG
ACCCTTGTCGATTGATCAATGTCAGAAAGGACACGGAGAAAACTCTACGC
GATATGCAAATTGTGGCGGATGAGTCGAACTGTTCGAGCCGATCGAAGAA
TTCCTACCACACCTATCCAGGCTATTCCCAAACCACAGTGCCATCAAAGT
CACCAAATGCTGTGTACAATCCAATGATGGATAAACCGAACTTTGATCTT
TACCCTCGATCTTCAATTTCAAATTATTATAATTCATCCCCAAATTTATT
GGGTCCAGGGATAAACAGTACCTTCCAGAAACTAGTTTCGGCTACCTGTC
CCGGTTCAACAGCGGGAGATTTGTCTCATCTGGCAAATATATCTTCCCAG
TTTAATAATACCGACCTGTTCACCAACAATTCAGACATTGCATCAACAGT
TCCTTTCAAATCTCTAGGAGGTGGTTTCATGATAAATAATCGCAACCCAA
CCAATTATCAGTCTCTTGACTATCATCCTGAAATGTGGACCTATCTCAAT
CCTAGCCGTTCGACAGCCTTTTCCTATTATGGAATGGGCGGTGAATACTG
CAATCCCACATATTCATATCTGAATTCACTCGGTATGGCCAACCACGACA
CTCCACAAACTCCGCTGGTTCCAATGAGTGACCATTCCGACCAAGACGCG
TCGTCAGGCTCCACAATGTACAGAAGTTTCACGGACTATTGTTATTAATC
TGCGCCCGAATCAATTGTTGATCCGTCAACACTCTCTGTGTCTGTGGTGT
ATCTGTTTTTCATAACATCAAAGTCCCATCGACCAGACCGGCTAATTATA
ACCCAAGTACCGCATCGTAGCTGGTGCGTTACAGTTGACTGACGAATTCG
TGCACCTCACTGTCATGCCCCAATACCCACCTGGGTTCGTTACATTAGCC
TCTCATCGACTCCGTCTATCCAGTTCCGAACATTTTTATGCCTCAGAGAT
TTTGCTGGTGTCATCATAACTATTTGTGAGAACACTCTAGTATATATAGC
TTGTGTGCGTATGCGTGTTCGTTTGCATTTGTGTGTCTCCTCACTAATTA
TCAGTAATAGTCAAGTGATAAATGGGATCCAA

protein sequence of SMED30019616-orf-1

>SMED30019616-orf-1 ID=SMED30019616-orf-1|Name=SMED30019616-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=397bp
MKLETIVRPDLSQLSNVYQQGSESASAIGGDQAISRASYMCRKCKVHGKL
VPVKRHKRTCLYLHCKCIKCLLVDQGRKVVAKQIALYRDQRHIGTEDRHS
SETQDQRLVSFKEYRLRGTTPSVKTNVSDKDAGMGPHCRRCRNHNVTVIW
KNHKKSCPYRHCPCDPCRLINVRKDTEKTLRDMQIVADESNCSSRSKNSY
HTYPGYSQTTVPSKSPNAVYNPMMDKPNFDLYPRSSISNYYNSSPNLLGP
GINSTFQKLVSATCPGSTAGDLSHLANISSQFNNTDLFTNNSDIASTVPF
KSLGGGFMINNRNPTNYQSLDYHPEMWTYLNPSRSTAFSYYGMGGEYCNP
TYSYLNSLGMANHDTPQTPLVPMSDHSDQDASSGSTMYRSFTDYCY*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000099	neuron

Vocabulary: **INTERPRO**
Term	Definition
IPR036407	DM_DNA-bd_sf
IPR026607	DMRT/dsx/mab-3
IPR001275	DM_DNA-bd

Vocabulary: **molecular function**
Term	Definition
GO:0043565	sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	transcription factor activity, sequence-specific DNA binding
GO:0046872	metal ion binding

Vocabulary: **biological process**
Term	Definition
GO:0006355	regulation of transcription, DNA-templated

Vocabulary: **cellular component**
Term	Definition
GO:0005634	nucleus

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001275	DM DNA-binding domain	SMART	SM00301	DM_3	coord: 37..90 e-value: 3.4E-10 score: 49.9 coord: 134..187 e-value: 2.0E-11 score: 54.0
IPR001275	DM DNA-binding domain	PFAM	PF00751	DM	coord: 136..175 e-value: 2.2E-13 score: 49.9 coord: 38..83 e-value: 1.9E-14 score: 53.3
IPR001275	DM DNA-binding domain	PROSITE	PS40000	DM_1	coord: 41..70
IPR001275	DM DNA-binding domain	PROSITE	PS40000	DM_1	coord: 138..167
IPR001275	DM DNA-binding domain	PROSITE	PS50809	DM_2	coord: 41..88 score: 11.017
IPR001275	DM DNA-binding domain	PROSITE	PS50809	DM_2	coord: 138..182 score: 10.757
IPR036407	DM DNA-binding domain superfamily	GENE3D	G3DSA:4.10.1040.10		coord: 131..178 e-value: 1.2E-14 score: 55.8 coord: 33..83 e-value: 3.1E-14 score: 54.4
IPR036407	DM DNA-binding domain superfamily	SUPERFAMILY	SSF82927	Cysteine-rich DNA binding domain, (DM domain)	coord: 36..81
IPR036407	DM DNA-binding domain superfamily	SUPERFAMILY	SSF82927	Cysteine-rich DNA binding domain, (DM domain)	coord: 135..175
None	No IPR available	PANTHER	PTHR12322:SF53	DOUBLESEX-MAB RELATED 99B	coord: 136..227
None	No IPR available	PANTHER	PTHR12322:SF53	DOUBLESEX-MAB RELATED 99B	coord: 38..97
IPR026607	DMRT/protein doublesex/protein male abnormal 3	PANTHER	PTHR12322	DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT	coord: 136..227
IPR026607	DMRT/protein doublesex/protein male abnormal 3	PANTHER	PTHR12322	DOUBLESEX AND MAB-3 RELATED TRANSCRIPTION FACTOR DMRT	coord: 38..97

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Doublesex and mab 3 transcription

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 6

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