E3 ubiquitin-protein ligase PDZRN3

Overview


Name	E3 ubiquitin-protein ligase PDZRN3
Smed ID	SMED30019612
Length (bp)	1347

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 ubiquitin-protein ligase PDZRN3 (SMED30019612) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 ubiquitin-protein ligase PDZRN3 (SMED30019612) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019612

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
nervous system	SMED30019612	h1SMcG0000423	dd_Smed_v4_14596_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30019612	h1SMcG0000423	dd_Smed_v4_14596_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
Match: PDZRN4 (PDZ domain containing ring finger 4 [Source:HGNC Symbol;Acc:HGNC:30552])

HSP 1 Score: 91.2781 bits (225), Expect = 6.718e-19
Identity = 40/76 (52.63%), Postives = 56/76 (73.68%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R++ LKERA ++  ER+G TTDDD  SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  565 MEWKVKIRSDGTRYITKRPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 640

HSP 2 Score: 51.9878 bits (123), Expect = 1.932e-6
Identity = 29/101 (28.71%), Postives = 59/101 (58.42%), Query Frame = 1

Query:  310 VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ-DQYFPEDNSN 609
            V+L + +  +  GLT+ Y   + + E +T +++SE++ NS+A+ +  +R G+ IL IN E V++R + + L    + + ++ ++   E Q D+ + ED  N
Sbjct:   81 VELCRVSSQEKLGLTVCY---RTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERN 178

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
Match: PDZRN3 (PDZ domain containing ring finger 3 [Source:HGNC Symbol;Acc:HGNC:17704])

HSP 1 Score: 90.8929 bits (224), Expect = 6.904e-19
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  576 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAK 643

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Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  576 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAK 643

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
Match: PDZRN3 (PDZ domain containing ring finger 3 [Source:HGNC Symbol;Acc:HGNC:17704])

HSP 1 Score: 91.2781 bits (225), Expect = 7.165e-19
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  636 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAK 703

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
Match: PDZRN4 (PDZ domain containing ring finger 4 [Source:HGNC Symbol;Acc:HGNC:30552])

HSP 1 Score: 90.8929 bits (224), Expect = 7.875e-19
Identity = 40/76 (52.63%), Postives = 56/76 (73.68%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R++ LKERA ++  ER+G TTDDD  SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  629 MEWKVKIRSDGTRYITKRPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 704

HSP 2 Score: 57.7658 bits (138), Expect = 3.073e-8
Identity = 51/227 (22.47%), Postives = 107/227 (47.14%), Query Frame = 1

Query:   28 FIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKN----------NSIQLKESR---EIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGL--DNVKI-----------------VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ-DQYFPEDNSN 609
            + + ++NGKD++  +H+EAV+ F  A +  +V++ R+           + +QL  +    +I ++  +   +L+      P      + D+  S    +     DN  I                 V+L + +  +  GLT+ Y   + + E +T +++SE++ NS+A+ +  +R G+ IL IN E V++R + + L    + + ++ ++   E Q D+ + ED  N
Sbjct:   19 YEVSQVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCY---RTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERN 242

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Celegans
Match: C50F7.6 (pep chromosome:WBcel235:IV:7720568:7722408:-1 gene:WBGene00016846.1 transcript:C50F7.6b.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C50F7.6)

HSP 1 Score: 71.633 bits (174), Expect = 1.886e-13
Identity = 33/66 (50.00%), Postives = 48/66 (72.73%), Query Frame = 1

Query: 1033 VTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL 1230
            V  +W +K+R DGS+Y+ +RP R++ LK+R  QV  ER   +TDDDA SE+KLGRY +K +R++ L
Sbjct:  197 VHYKWKVKRRCDGSRYIVKRPIRSQILKKREAQVYRERAPISTDDDAMSELKLGRYHTKEERKRIL 262

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Celegans
Match: C50F7.6 (pep chromosome:WBcel235:IV:7720566:7723199:-1 gene:WBGene00016846.1 transcript:C50F7.6a.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:C50F7.6)

HSP 1 Score: 72.0182 bits (175), Expect = 2.141e-13
Identity = 33/68 (48.53%), Postives = 49/68 (72.06%), Query Frame = 1

Query: 1033 VTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            V  +W +K+R DGS+Y+ +RP R++ LK+R  QV  ER   +TDDDA SE+KLGRY +K +R++ L +
Sbjct:  282 VHYKWKVKRRCDGSRYIVKRPIRSQILKKREAQVYRERAPISTDDDAMSELKLGRYHTKEERKRILER 349

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Fly
Match: Slip1 (gene:FBgn0024728 transcript:FBtr0089090)

HSP 1 Score: 73.1738 bits (178), Expect = 1.739e-13
Identity = 38/96 (39.58%), Postives = 62/96 (64.58%), Query Frame = 1

Query:  973 SSLQKSSKNIDNNKLYENLPVTMEWVLKKRPDGSKYVTRRPKRNKF-LKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFKSH 1257
            +SLQK++  + N +  E +P  M W +K+RPDG++Y+ +RP RN+  +  R      E T  TT+DD  SE+K+GRYW+K +R++H+ + R  + H
Sbjct:  670 TSLQKNA-TLLNGESAEEIP--MVWKVKRRPDGTRYIVKRPVRNRPQVALRKNMRYNEVT--TTEDDTISEVKIGRYWTKEERKRHIERAREKRHH 760

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Fly
Match: Slip1 (gene:FBgn0024728 transcript:FBtr0310536)

HSP 1 Score: 72.7886 bits (177), Expect = 2.680e-13
Identity = 38/96 (39.58%), Postives = 62/96 (64.58%), Query Frame = 1

Query:  973 SSLQKSSKNIDNNKLYENLPVTMEWVLKKRPDGSKYVTRRPKRNKF-LKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFKSH 1257
            +SLQK++  + N +  E +P  M W +K+RPDG++Y+ +RP RN+  +  R      E T  TT+DD  SE+K+GRYW+K +R++H+ + R  + H
Sbjct:  564 TSLQKNA-TLLNGESAEEIP--MVWKVKRRPDGTRYIVKRPVRNRPQVALRKNMRYNEVT--TTEDDTISEVKIGRYWTKEERKRHIERAREKRHH 654

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Match: BX640588.1 (pep chromosome:GRCz11:CHR_ALT_CTG6_1_42:44244096:44258433:-1 gene:ENSDARG00000115237.1 transcript:ENSDART00000180410.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:BX640588.1)

HSP 1 Score: 90.8929 bits (224), Expect = 5.852e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  651 DLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQH 718

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Match: pdzrn3b (PDZ domain containing RING finger 3b [Source:NCBI gene;Acc:100005518])

HSP 1 Score: 90.8929 bits (224), Expect = 6.962e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  861 DLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQH 928

HSP 2 Score: 54.6842 bits (130), Expect = 2.170e-7
Identity = 47/213 (22.07%), Postives = 95/213 (44.60%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARK------------NNSIQLKESREIRYQLPLITEELKCGIESSPIKSSKNI---RDASQSSRYSDT-----GLDNVKI--------VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQY 588
            I+++NGKD++  +HD+AV+ F  A +  +V++ R+               + +    +I +Q  +   +L     S+P+   +        S +  Y D      G+ +           V L +       G T+ Y   + + E ET +++SEI+ NS+A+ +  +R G+ I+ IN   +++R + + L    +   V  +L   E Q ++
Sbjct:  303 IMEVNGKDLSKATHDQAVEAFRMAKEPIMVQVLRRAPRPKPTGPTGEGQVVDISTQTDITFQHIMALSKLP--TSSTPVDVLEQYLLPEGHSPAHEYFDPNDFLEGMQHEIEREELEYEEVDLYRTNIHDKLGFTVCY---RTDDEDETGIYVSEIDPNSIAAKDGRIREGDRIIQINGIEIQNREEAVALLTSEEHPNVCLLLARPEIQKKH 510

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Match: pdzrn3b (PDZ domain containing RING finger 3b [Source:NCBI gene;Acc:100005518])

HSP 1 Score: 90.5077 bits (223), Expect = 7.578e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  871 DLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQH 938

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Match: pdzrn3b (PDZ domain containing RING finger 3b [Source:NCBI gene;Acc:100005518])

HSP 1 Score: 90.5077 bits (223), Expect = 8.237e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  900 DLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQH 967

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Match: pdzrn4 (PDZ domain containing ring finger 4 [Source:ZFIN;Acc:ZDB-GENE-041210-237])

HSP 1 Score: 86.6557 bits (213), Expect = 1.160e-17
Identity = 37/65 (56.92%), Postives = 52/65 (80.00%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKHL 1230
            +EW +K R DG++YV RRP R++ L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++ L
Sbjct:  641 LEWKVKVRADGTRYVARRPARDRILRERALRIREERSGGMTTDDDAVSELKMGRYWSKEERKQQL 705

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BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Match: frem2 (FRAS1 related extracellular matrix protein 2 [Source:Xenbase;Acc:XB-GENE-1004431])

HSP 1 Score: 94.7449 bits (234), Expect = 4.280e-20
Identity = 39/66 (59.09%), Postives = 55/66 (83.33%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H+R+
Sbjct:  575 MEWKVKVRSDGTRYITKRPVRDKLLKERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHVRR 640

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Match: frem2 (FRAS1 related extracellular matrix protein 2 [Source:Xenbase;Acc:XB-GENE-1004431])

HSP 1 Score: 94.7449 bits (234), Expect = 5.685e-20
Identity = 39/66 (59.09%), Postives = 55/66 (83.33%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H+R+
Sbjct:  876 MEWKVKVRSDGTRYITKRPVRDKLLKERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHVRR 941

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Match: frem2 (FRAS1 related extracellular matrix protein 2 [Source:Xenbase;Acc:XB-GENE-1004431])

HSP 1 Score: 94.3597 bits (233), Expect = 6.026e-20
Identity = 39/66 (59.09%), Postives = 55/66 (83.33%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H+R+
Sbjct:  886 MEWKVKVRSDGTRYITKRPVRDKLLKERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHVRR 951

HSP 2 Score: 52.7582 bits (125), Expect = 1.090e-6
Identity = 49/215 (22.79%), Postives = 96/215 (44.65%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIES--------------SPIKSSKNI------RDASQSSRYSDT-----GL------DNVKI--VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ 579
            I+++NGKD++  +HD+AV+ F  A +  +V++ R+    ++       +  P   + L  G ++              SP  S   +       + S +  Y D      GL      D +++  + L +       GLT+ Y   + + E +T +++SEI+ NS+A+ +  +R G+ I+ IN   V +  + + L    D + V  ++   E Q
Sbjct:  272 IIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKV-------FSPPADVQLLDMGTQTEITFEHIAALTKIGSPSPSVAGLDPYLLTEEHSPAHDYFDPNDFMGGLHPEMDRDELELEEIDLYRMNSQDKLGLTVCY---RTDDEDDTGIYVSEIDPNSIAAKDGRIREGDRIIQINGIDVNNHEEAVALLTSEDTKNVFLLVARPELQ 476

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Match: frem2 (FRAS1 related extracellular matrix protein 2 [Source:Xenbase;Acc:XB-GENE-1004431])

HSP 1 Score: 94.3597 bits (233), Expect = 6.097e-20
Identity = 39/66 (59.09%), Postives = 55/66 (83.33%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H+R+
Sbjct:  915 MEWKVKVRSDGTRYITKRPVRDKLLKERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHVRR 980

HSP 2 Score: 52.7582 bits (125), Expect = 1.216e-6
Identity = 49/215 (22.79%), Postives = 96/215 (44.65%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIES--------------SPIKSSKNI------RDASQSSRYSDT-----GL------DNVKI--VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ 579
            I+++NGKD++  +HD+AV+ F  A +  +V++ R+    ++       +  P   + L  G ++              SP  S   +       + S +  Y D      GL      D +++  + L +       GLT+ Y   + + E +T +++SEI+ NS+A+ +  +R G+ I+ IN   V +  + + L    D + V  ++   E Q
Sbjct:  301 IIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKV-------FSPPADVQLLDMGTQTEITFEHIAALTKIGSPSPSVAGLDPYLLTEEHSPAHDYFDPNDFMGGLHPEMDRDELELEEIDLYRMNSQDKLGLTVCY---RTDDEDDTGIYVSEIDPNSIAAKDGRIREGDRIIQINGIDVNNHEEAVALLTSEDTKNVFLLVARPELQ 505

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Match: frem2 (FRAS1 related extracellular matrix protein 2 [Source:Xenbase;Acc:XB-GENE-1004431])

HSP 1 Score: 94.3597 bits (233), Expect = 6.851e-20
Identity = 39/66 (59.09%), Postives = 55/66 (83.33%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRK 1236
            MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H+R+
Sbjct:  892 MEWKVKVRSDGTRYITKRPVRDKLLKERAIKIKEERSGMTTDDDAISEMKMGRYWSKEERKQHVRR 957

HSP 2 Score: 52.7582 bits (125), Expect = 1.054e-6
Identity = 49/215 (22.79%), Postives = 96/215 (44.65%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIES--------------SPIKSSKNI------RDASQSSRYSDT-----GL------DNVKI--VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ 579
            I+++NGKD++  +HD+AV+ F  A +  +V++ R+    ++       +  P   + L  G ++              SP  S   +       + S +  Y D      GL      D +++  + L +       GLT+ Y   + + E +T +++SEI+ NS+A+ +  +R G+ I+ IN   V +  + + L    D + V  ++   E Q
Sbjct:  301 IIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKV-------FSPPADVQLLDMGTQTEITFEHIAALTKIGSPSPSVAGLDPYLLTEEHSPAHDYFDPNDFMGGLHPEMDRDELELEEIDLYRMNSQDKLGLTVCY---RTDDEDDTGIYVSEIDPNSIAAKDGRIREGDRIIQINGIDVNNHEEAVALLTSEDTKNVFLLVARPELQ 505

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Match: Pdzrn4 (PDZ domain containing RING finger 4 [Source:MGI Symbol;Acc:MGI:3056996])

HSP 1 Score: 90.8929 bits (224), Expect = 5.641e-19
Identity = 40/76 (52.63%), Postives = 56/76 (73.68%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R++ LKERA ++  ER+G TTDDD  SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  626 MEWKVKIRSDGTRYITKRPVRDRLLKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 701

HSP 2 Score: 56.225 bits (134), Expect = 5.932e-8
Identity = 48/227 (21.15%), Postives = 106/227 (46.70%), Query Frame = 1

Query:   28 FIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNN----------SIQLKESR---EIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGL-----------------DNVKI--VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLE-VVLTVLQNSENQDQYFPEDNSN 609
            + + ++NG+D++  +H+EAV+ F  A +  +V++ R+             +QL  +    +I ++  +   +L+      P      + D+  S    + G                  D+ +   V+L + +  +  GLT+ Y   + + E +T +++SE++ NS+A+ +  +R G+ IL IN E +++R + + L    + + +VL + +     D+ + ED  N
Sbjct:   19 YEVSQVNGRDLSKATHEEAVEAFRTAKEPIVVQVLRRTPLSRPTYGMTPEVQLTNASTQTDITFEHIMALAKLRPLTPPVPDTCPFLLSDSCHSLHPMEHGFYEDHEYVSSLPADADRADDFEYEEVELCRVSSQEKLGLTVCY---RTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDIQNREEAVALLSSDECKRIVLLIARPDMQLDEGWLEDERN 242

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Match: Pdzrn3 (PDZ domain containing RING finger 3 [Source:MGI Symbol;Acc:MGI:1933157])

HSP 1 Score: 90.8929 bits (224), Expect = 6.640e-19
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  916 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAK 983

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Match: Pdzrn4 (PDZ domain containing RING finger 4 [Source:MGI Symbol;Acc:MGI:3056996])

HSP 1 Score: 89.7373 bits (221), Expect = 1.594e-18
Identity = 40/76 (52.63%), Postives = 56/76 (73.68%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R++ LKERA ++  ER+G TTDDD  SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  865 MEWKVKIRSDGTRYITKRPVRDRLLKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 940

HSP 2 Score: 57.7658 bits (138), Expect = 2.066e-8
Identity = 49/225 (21.78%), Postives = 105/225 (46.67%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNN----------SIQLKESR---EIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGL-----------------DNVKI--VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLE-VVLTVLQNSENQDQYFPEDNSN 609
            I+ +NG+D++  +H+EAV+ F  A +  +V++ R+             +QL  +    +I ++  +   +L+      P      + D+  S    + G                  D+ +   V+L + +  +  GLT+ Y   + + E +T +++SE++ NS+A+ +  +R G+ IL IN E +++R + + L    + + +VL + +     D+ + ED  N
Sbjct:  260 IIAVNGRDLSKATHEEAVEAFRTAKEPIVVQVLRRTPLSRPTYGMTPEVQLTNASTQTDITFEHIMALAKLRPLTPPVPDTCPFLLSDSCHSLHPMEHGFYEDHEYVSSLPADADRADDFEYEEVELCRVSSQEKLGLTVCY---RTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDIQNREEAVALLSSDECKRIVLLIARPDMQLDEGWLEDERN 481

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Match: Pdzd4 (PDZ domain containing 4 [Source:MGI Symbol;Acc:MGI:2443483])

HSP 1 Score: 88.5817 bits (218), Expect = 3.320e-18
Identity = 41/76 (53.95%), Postives = 55/76 (72.37%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++YV +RP R++ LK RA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL      RK R F
Sbjct:  625 MEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREF 700

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Match: Pdzd4 (PDZ domain containing 4 [Source:MGI Symbol;Acc:MGI:2443483])

HSP 1 Score: 88.1965 bits (217), Expect = 3.890e-18
Identity = 41/76 (53.95%), Postives = 55/76 (72.37%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++YV +RP R++ LK RA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL      RK R F
Sbjct:  510 MEWKVKVRSDGTRYVAKRPVRDRLLKARALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLIRAREQRKRREF 585

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Match: sp|Q69ZS0|PZRN3_MOUSE (E3 ubiquitin-protein ligase PDZRN3 OS=Mus musculus OX=10090 GN=Pdzrn3 PE=1 SV=3)

HSP 1 Score: 90.8929 bits (224), Expect = 4.645e-18
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  916 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAK 983

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Match: sp|P68907|PZRN3_RAT (E3 ubiquitin-protein ligase PDZRN3 OS=Rattus norvegicus OX=10116 GN=Pdzrn3 PE=1 SV=1)

HSP 1 Score: 90.8929 bits (224), Expect = 5.170e-18
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  915 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAK 982

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Match: sp|E7FDW2|PZR3B_DANRE (E3 ubiquitin-protein ligase PDZRN3-B OS=Danio rerio OX=7955 GN=pdzrn3b PE=1 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 6.218e-18
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  900 DLGPKMEWKVKIRSDGTRYITKRPVRDKLLKERALRIREERSGMTTDDDAVSEMKMGRYWSKEERKQH 967

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Match: sp|Q9UPQ7|PZRN3_HUMAN (E3 ubiquitin-protein ligase PDZRN3 OS=Homo sapiens OX=9606 GN=PDZRN3 PE=1 SV=2)

HSP 1 Score: 90.5077 bits (223), Expect = 6.713e-18
Identity = 38/68 (55.88%), Postives = 55/68 (80.88%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+G TTDDDA SE+K+GRYWSK +R++HL K +
Sbjct:  919 MEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGMTTDDDAVSEMKMGRYWSKEERKQHLVKAK 986

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Match: sp|Q6ZMN7|PZRN4_HUMAN (PDZ domain-containing RING finger protein 4 OS=Homo sapiens OX=9606 GN=PDZRN4 PE=2 SV=3)

HSP 1 Score: 89.7373 bits (221), Expect = 1.105e-17
Identity = 40/76 (52.63%), Postives = 56/76 (73.68%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R++ LKERA ++  ER+G TTDDD  SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  887 MEWKVKIRSDGTRYITKRPVRDRILKERALKIKEERSGMTTDDDTMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 962

HSP 2 Score: 60.077 bits (144), Expect = 3.098e-8
Identity = 52/225 (23.11%), Postives = 107/225 (47.56%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKN----------NSIQLKESR---EIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGL--DNVKI-----------------VKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ-DQYFPEDNSN 609
            I+++NGKD++  +H+EAV+ F  A +  +V++ R+           + +QL  +    +I ++  +   +L+      P      + D+  S    +     DN  I                 V+L + +  +  GLT+ Y   + + E +T +++SE++ NS+A+ +  +R G+ IL IN E V++R + + L    + + ++ ++   E Q D+ + ED  N
Sbjct:  279 IMEVNGKDLSKATHEEAVEAFRNAKEPIVVQVLRRTPLSRPAYGMASEVQLMNASTQTDITFEHIMALAKLRPPTPPVPDICPFLLSDSCHSLHPMEHEFYEDNEYISSLPADADRTEDFEYEEVELCRVSSQEKLGLTVCY---RTDDEEDTGIYVSEVDPNSIAAKDGRIREGDRILQINGEDVQNREEAVALLSNDECKRIVLLVARPEIQLDEGWLEDERN 500

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Match: A0A2H1CRH0 (Uncharacterized protein OS=Fasciola hepatica OX=6192 GN=D915_02405 PE=4 SV=1)

HSP 1 Score: 110.153 bits (274), Expect = 1.701e-23
Identity = 51/84 (60.71%), Postives = 66/84 (78.57%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRR-FKSHQTNVIEKYTT 1287
            MEWV+KKRPDGS+Y+TRRP RN+ LKERA++V  ER+G TTDDDA SE+K+GRYW++++RRK L K R   K  QT V+   T+
Sbjct:  170 MEWVVKKRPDGSRYITRRPIRNRLLKERARRVAEERSGLTTDDDAVSELKVGRYWNRTERRKQLEKARADRKKRQTTVVAATTS 253

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Match: V3ZFH3 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_164582 PE=4 SV=1)

HSP 1 Score: 105.531 bits (262), Expect = 2.300e-23
Identity = 46/71 (64.79%), Postives = 58/71 (81.69%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFK 1251
            MEWV+K+RPDG++Y+TRRP RNK LKER K++  ER G TTDDDA SE+K GRYWSK DR+KH+ K R ++
Sbjct:    1 MEWVVKRRPDGTRYITRRPVRNKLLKERGKKIHDERQGMTTDDDAMSEMKTGRYWSKEDRKKHVEKARDYR 71

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Match: A0A183A5R4 (Uncharacterized protein OS=Echinostoma caproni OX=27848 GN=ECPE_LOCUS2299 PE=4 SV=1)

HSP 1 Score: 108.612 bits (270), Expect = 3.594e-23
Identity = 50/79 (63.29%), Postives = 64/79 (81.01%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR-RFKSHQTNVI 1272
            MEWV+KKRPDGS+Y+TRRP RN+ LKERA++V  ER+G TTDDDA SE+K+GRYW++++RRK L K R   K  QT V+
Sbjct:  156 MEWVVKKRPDGSRYITRRPIRNRLLKERARRVAEERSGLTTDDDATSELKVGRYWNRTERRKQLEKARAERKKRQTAVV 234

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Match: A0A4E0S3K5 (PDZ domain-containing protein 4 OS=Fasciola hepatica OX=6192 GN=D915_001377 PE=4 SV=1)

HSP 1 Score: 112.464 bits (280), Expect = 1.294e-22
Identity = 51/84 (60.71%), Postives = 66/84 (78.57%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRR-FKSHQTNVIEKYTT 1287
            MEWV+KKRPDGS+Y+TRRP RN+ LKERA++V  ER+G TTDDDA SE+K+GRYW++++RRK L K R   K  QT V+   T+
Sbjct: 1308 MEWVVKKRPDGSRYITRRPIRNRLLKERARRVAEERSGLTTDDDAVSELKVGRYWNRTERRKQLEKARADRKKRQTTVVAATTS 1391

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Match: A0A2T7NUN7 (PDZ domain-containing protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_15361 PE=4 SV=1)

HSP 1 Score: 110.923 bits (276), Expect = 3.448e-22
Identity = 45/71 (63.38%), Postives = 61/71 (85.92%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFK 1251
            MEWV+K+RPDG++Y+TRRP R+K LKERAK+++ ER+G TTDDDA SE+K GRYWSK +R++HL K + +K
Sbjct:  658 MEWVVKRRPDGTRYITRRPVRSKILKERAKKIMEERSGMTTDDDAMSELKTGRYWSKEERKRHLEKAKDYK 728

HSP 2 Score: 73.1738 bits (178), Expect = 5.100e-10
Identity = 60/193 (31.09%), Postives = 96/193 (49.74%), Query Frame = 1

Query:   40 KINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGLDNVKIVKLTKC-----TRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDN 603
            ++NG+D++  SHDEAV+ F  A +  +VE+ R+ +S   + S +                   P+  S  +++AS        GL       L KC     T ++  GLTL Y    LE EV T +FISE++ +S+A  +  ++ G++IL IN   V SRS+ I LF   D +++L V +     D  F E++
Sbjct:   33 EVNGQDLSQSSHDEAVEAFRTATEPIIVEVLRRVSSGSNRGSGKY-----------------IPVALSTILKEAS--------GL-------LPKCGDGRTTSNEKLGLTLCYG--SLEDEV-TDIFISEVDPSSVAGRDGRIKEGDQILQINGIDVHSRSEAISLFASQDPDIMLLVARPQLQMDDGFMEES 190

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Match: pdzrn4 (PDZ domain-containing RING finger protein 4 [Source:NCBI gene;Acc:103047366])

HSP 1 Score: 90.1225 bits (222), Expect = 9.187e-19
Identity = 39/68 (57.35%), Postives = 53/68 (77.94%), Query Frame = 1

Query: 1030 PVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKHL 1230
            P  +EW +K R DG+KYV RRP R++ L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++ L
Sbjct:  651 PGRLEWKVKVRADGTKYVARRPARDRILRERALRIREERSGGMTTDDDAASELKMGRYWSKEERKQQL 718

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Match: pdzrn3b (PDZ domain containing ring finger 3 [Source:NCBI gene;Acc:103033977])

HSP 1 Score: 88.1965 bits (217), Expect = 4.191e-18
Identity = 38/70 (54.29%), Postives = 56/70 (80.00%), Query Frame = 1

Query: 1021 ENLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKH 1227
            ++L   MEW +K R DG++Y+T+RP R++ L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++H
Sbjct:  886 QDLEPKMEWKVKIRSDGTRYITKRPVRDRLLRERALRIREERSGGMTTDDDAVSELKMGRYWSKEERKQH 955

HSP 2 Score: 52.7582 bits (125), Expect = 5.700e-7
Identity = 46/206 (22.33%), Postives = 93/206 (45.15%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARK-----------NNSIQLKESREIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTG--LDNVK-----------IVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQ 579
            I+++NGKD++  +H++AV+ F  A +  +V++ R+              + +    +I +Q  +   +L        ++        S +  Y D    LD ++            V L +       GLT+ Y   + + E ET +++SEI+ NS+A+ +  +R G+ I+ IN   V++R + + L    + + V  ++   E Q
Sbjct:  304 IMEVNGKDLSKATHEQAVEAFRTAKEPIMVQVLRRVPRPKPAPDGETQVVDISTQTDITFQHIMALSKLPASTPPP-LEPYLLPEGHSPAHEYFDPNDFLDGMQQDMEREELEYEEVDLYRTNIQDKLGLTVCY---RTDDEDETGIYVSEIDPNSIAARDGRIREGDRIIQINGIEVQNREEAVALLTSEENQNVCLLVARPEIQ 505

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Match: si:ch73-162j3.4 (PDZ domain-containing protein 4-like [Source:NCBI gene;Acc:103035084])

HSP 1 Score: 85.8853 bits (211), Expect = 2.201e-17
Identity = 40/75 (53.33%), Postives = 54/75 (72.00%), Query Frame = 1

Query: 1015 LYENLPVT---MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL 1230
            L  +LP     MEW +K R DGS+YV +RP R++ LK RA ++  ER+G TTDDDA SE+K+GRYWSK +R++ L
Sbjct:  709 LVSSLPQASPRMEWKVKIRSDGSRYVAKRPVRDRLLKARAMKISEERSGMTTDDDAVSEMKMGRYWSKEERKQQL 783

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Match: PDZD4 (PDZ domain containing 4 [Source:HGNC Symbol;Acc:HGNC:21167])

HSP 1 Score: 85.5001 bits (210), Expect = 2.578e-17
Identity = 38/68 (55.88%), Postives = 52/68 (76.47%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            MEW +K R DG++YV +RP R++ LK RA ++  ER+G TTDDDA SE+K+GRYWSK +R++ L K R
Sbjct:  597 MEWKVKIRSDGTRYVAKRPVRDRLLKARAMKIREERSGMTTDDDAVSEMKMGRYWSKEERKQQLLKAR 664

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Match: pdzrn3a (E3 ubiquitin-protein ligase PDZRN3 [Source:NCBI gene;Acc:103022706])

HSP 1 Score: 83.9593 bits (206), Expect = 9.238e-17
Identity = 34/63 (53.97%), Postives = 49/63 (77.78%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            MEW +K R DG++Y+T+RP + + L+ERA ++  ER G TTDDD  SE+K+GRYWSK +R++H
Sbjct:  854 MEWKVKIRSDGTRYITKRPAKEQLLRERALRIREERRGMTTDDDTVSELKMGRYWSKEERKQH 916

HSP 2 Score: 56.9954 bits (136), Expect = 2.966e-8
Identity = 53/223 (23.77%), Postives = 105/223 (47.09%), Query Frame = 1

Query:   34 ILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIAR-----KNNSIQLKESREI----RYQLPLITEELKCGIESSPIKSSKNIRDA-----------SQSS-----------RYSDTGLDNVKIVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDNSN 609
            I+K+N ++++  +HD+AV+ F  A D   VE+ R     K +S  + ++R +    + ++ L   E    + S P     ++ D            S SS           +Y + G    + V L K +     GLTL Y   + ++E ET +++SEI+  S+A+ +  +R G++I+ IN   +++  + + +  + +   V  +L   E QD  + E++ +
Sbjct:  257 IIKVNNRELSLATHDDAVEAFLMARDPIEVEVLRRVAPTKTSSALIPDTRGVDTTTQTEISLEHVEAVTKLTSPPTPVGMSVMDKHKYQPTESEMLSYSSLYPTGFFEDMPKYPERGELEYEEVDLQKRSTQDKLGLTLCY---KTDEEEETGIYVSEIDPGSIAAQDGRVREGDQIIQINGVDIQNHEEAVAVLSKGNCRNVRLLLARPEIQDDGWLEEDEH 476

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000743.1 (pep scaffold:Pmarinus_7.0:GL478474:22919:40568:-1 gene:ENSPMAG00000000678.1 transcript:ENSPMAT00000000743.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 89.7373 bits (221), Expect = 1.829e-19
Identity = 38/63 (60.32%), Postives = 51/63 (80.95%), Query Frame = 1

Query: 1042 EWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHL 1230
            EW +K R DGS+Y+T+RP R++ LKERA ++  ER+G TTDDDA SE+K+GRYWSK  R++HL
Sbjct:  474 EWKVKVRSDGSRYITKRPVRDRLLKERAMKIKEERSGMTTDDDALSEMKMGRYWSKEQRKQHL 536

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Match: PDZRN4 (PDZ domain-containing RING finger protein 4 [Source:NCBI gene;Acc:101159985])

HSP 1 Score: 92.4337 bits (228), Expect = 1.164e-19
Identity = 42/77 (54.55%), Postives = 58/77 (75.32%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R+K L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  472 MEWKVKIRSDGTRYITKRPVRDKILRERALKIKEERSGGMTTDDDAMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 548

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Match: PDZRN4 (PDZ domain-containing RING finger protein 4 [Source:NCBI gene;Acc:101159985])

HSP 1 Score: 92.0485 bits (227), Expect = 1.684e-19
Identity = 42/77 (54.55%), Postives = 58/77 (75.32%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKHL------RKYRRF 1248
            MEW +K R DG++Y+T+RP R+K L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++HL      R+ R F
Sbjct:  605 MEWKVKIRSDGTRYITKRPVRDKILRERALKIKEERSGGMTTDDDAMSEMKMGRYWSKEERKQHLVRAKEQRRRREF 681

HSP 2 Score: 52.373 bits (124), Expect = 7.522e-7
Identity = 49/209 (23.44%), Postives = 93/209 (44.50%), Query Frame = 1

Query:   28 FIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNS------------IQLKESREIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDT----GLDNVKIVK---------------LTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVI-DLFRQSDLEVVLTV 558
            + I ++NGK+++  SHDE V+ F  A D  +V++ R+  S            + +    +I ++  +   +L+      P      + D+  S    +     G D +  V                L + +  +  GLTL Y   + ++E + ++++SE+  NS+A+ +  +R G+ IL IN + VK R + +  LF      +VL V
Sbjct:   19 YEIAQVNGKELSKSSHDETVEAFRAARDPVVVQVIRRTPSGHPHGLPQEIHVVDVCTQTDITFEHIMALAKLRPTTPPVPDVCPFLLSDSCHSLHTMEQDYFEGTDYLSGVPAEGDRTEEYEYEEVELCRLSSQEKLGLTLCY---RTDEEEDMAIYVSEVCPNSIAANDGRIREGDRILQINGQDVKDREEAMAALFNDESRNIVLLV 224

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Match: pdzrn4 (PDZ domain containing ring finger 4 [Source:NCBI gene;Acc:101165610])

HSP 1 Score: 90.8929 bits (224), Expect = 4.283e-19
Identity = 39/69 (56.52%), Postives = 55/69 (79.71%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGG-TTDDDAHSEIKLGRYWSKSDRRKHLRKYR 1242
            +EW +K R DG++YV RRP R++ L+ERA ++  ER+GG TTDDDA SE+K+GRYWSK +R++HL + R
Sbjct:  670 LEWKVKVRADGTRYVARRPARDRILRERALRIREERSGGMTTDDDAMSEMKMGRYWSKEERKQHLARAR 738

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Match: pdzrn3b (PDZ domain containing ring finger 3 [Source:NCBI gene;Acc:101166295])

HSP 1 Score: 90.5077 bits (223), Expect = 6.707e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  862 DLEPKMEWKVKIRSDGTRYITKRPVRDKLLKERAIRIHEERSGLTTDDDAISELKMGRYWSKEERKQH 929

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Match: pdzrn3b (PDZ domain containing ring finger 3 [Source:NCBI gene;Acc:101166295])

HSP 1 Score: 90.5077 bits (223), Expect = 7.162e-19
Identity = 39/68 (57.35%), Postives = 54/68 (79.41%), Query Frame = 1

Query: 1024 NLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKH 1227
            +L   MEW +K R DG++Y+T+RP R+K LKERA ++  ER+G TTDDDA SE+K+GRYWSK +R++H
Sbjct:  891 DLEPKMEWKVKIRSDGTRYITKRPVRDKLLKERAIRIHEERSGLTTDDDAISELKMGRYWSKEERKQH 958

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Match: SMESG000070317.1 (SMESG000070317.1)

HSP 1 Score: 901.353 bits (2328), Expect = 0.000e+0
Identity = 441/442 (99.77%), Postives = 442/442 (100.00%), Query Frame = 1

Query:   22 MDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGLDNVKIVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDNSNPSLGINNQLFFGLRETDILSSDNASSQSEDDKLFEIDVNSSVDREAIKSNMECIDKLMNNLSLTYSSLMSINISENAAVTMDLLKDMPCLKACSKINEIDEMEKDFDIHNLPKKCILNISESSLQKSSKNIDNNKLYENLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFKSHQTNVIEKYTTKQTHDCHDITNKNSLCSNVS 1347
            MDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIES+PIKSSKNIRDASQSSRYSDTGLDNVKIVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDNSNPSLGINNQLFFGLRETDILSSDNASSQSEDDKLFEIDVNSSVDREAIKSNMECIDKLMNNLSLTYSSLMSINISENAAVTMDLLKDMPCLKACSKINEIDEMEKDFDIHNLPKKCILNISESSLQKSSKNIDNNKLYENLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFKSHQTNVIEKYTTKQTHDCHDITNKNSLCSNVS
Sbjct:    1 MDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSIQLKESREIRYQLPLITEELKCGIESTPIKSSKNIRDASQSSRYSDTGLDNVKIVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDNSNPSLGINNQLFFGLRETDILSSDNASSQSEDDKLFEIDVNSSVDREAIKSNMECIDKLMNNLSLTYSSLMSINISENAAVTMDLLKDMPCLKACSKINEIDEMEKDFDIHNLPKKCILNISESSLQKSSKNIDNNKLYENLPVTMEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFKSHQTNVIEKYTTKQTHDCHDITNKNSLCSNVS 442

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Match: SMESG000080284.1 (SMESG000080284.1)

HSP 1 Score: 102.449 bits (254), Expect = 3.087e-23
Identity = 42/71 (59.15%), Postives = 56/71 (78.87%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRRKHLRKYRRFK 1251
            M+WV+KKR DGSKY+ +RP RN+FLK+RAKQ+  +R   +TDDDA SEIK GRYW +++RR+   KYR +K
Sbjct:  426 MQWVMKKRSDGSKYLVKRPIRNQFLKDRAKQLTEDRQAISTDDDAASEIKTGRYWPRAERRRQFEKYREYK 496

HSP 2 Score: 50.8322 bits (120), Expect = 1.593e-6
Identity = 32/94 (34.04%), Postives = 50/94 (53.19%), Query Frame = 1

Query:  334 DQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPEDNSNPS 615
            DQ YGLTL Y     +  V + +F+ EIE  S AS    +R+G+++L IN + V +R QV+ LF  S   + L + +++  Q Q   +    P 
Sbjct:  104 DQKYGLTLFYCQNSSDPNV-SDIFVGEIEPLSPASLAKGMRLGDQVLQINHQDVFTRDQVMHLFALSVNHIHLLLARSASQQLQLMAQSQLQPP 196

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Match: SMESG000021620.1 (SMESG000021620.1)

HSP 1 Score: 81.2629 bits (199), Expect = 4.206e-16
Identity = 32/61 (52.46%), Postives = 48/61 (78.69%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRR 1221
            MEWV+KKRPDG++Y+TRRP RN+ +K+R K++  ER   T ++D H+++ L R W+KSD+R
Sbjct:  575 MEWVVKKRPDGTRYITRRPIRNRMMKDREKKLNEERNYTTEEEDIHADLVLNRCWTKSDKR 635

HSP 2 Score: 65.4698 bits (158), Expect = 3.988e-11
Identity = 33/70 (47.14%), Postives = 47/70 (67.14%), Query Frame = 1

Query:  343 YGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVL 552
            +GLTLSY  L      E+ V+IS IE NS+A    N+R+G++IL IN+  V S++QV+ LF++  LEV L
Sbjct:  173 FGLTLSYSALSASDNSESEVYISAIEPNSVAKKEPNIRLGDQILQINNIDVHSKAQVVSLFQKCGLEVKL 242

HSP 3 Score: 53.1434 bits (126), Expect = 3.221e-7
Identity = 21/39 (53.85%), Postives = 30/39 (76.92%), Query Frame = 1

Query:   22 MDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARK 138
            MDFIILK+NGKD++T SH + ++ FN A +   VE+AR+
Sbjct:    1 MDFIILKVNGKDLSTASHQQVLEAFNSASEPIFVEVARR 39

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Match: SMESG000021620.1 (SMESG000021620.1)

HSP 1 Score: 81.2629 bits (199), Expect = 4.324e-16
Identity = 32/61 (52.46%), Postives = 48/61 (78.69%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRR 1221
            MEWV+KKRPDG++Y+TRRP RN+ +K+R K++  ER   T ++D H+++ L R W+KSD+R
Sbjct:  576 MEWVVKKRPDGTRYITRRPIRNRMMKDREKKLNEERNYTTEEEDIHADLVLNRCWTKSDKR 636

HSP 2 Score: 65.4698 bits (158), Expect = 4.026e-11
Identity = 33/70 (47.14%), Postives = 47/70 (67.14%), Query Frame = 1

Query:  343 YGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVL 552
            +GLTLSY  L      E+ V+IS IE NS+A    N+R+G++IL IN+  V S++QV+ LF++  LEV L
Sbjct:  173 FGLTLSYSALSASDNSESEVYISAIEPNSVAKKEPNIRLGDQILQINNIDVHSKAQVVSLFQKCGLEVKL 242

HSP 3 Score: 53.1434 bits (126), Expect = 3.222e-7
Identity = 21/39 (53.85%), Postives = 30/39 (76.92%), Query Frame = 1

Query:   22 MDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARK 138
            MDFIILK+NGKD++T SH + ++ FN A +   VE+AR+
Sbjct:    1 MDFIILKVNGKDLSTASHQQVLEAFNSASEPIFVEVARR 39

[Close]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Match: SMESG000021620.1 (SMESG000021620.1)

HSP 1 Score: 80.8777 bits (198), Expect = 4.581e-16
Identity = 32/61 (52.46%), Postives = 48/61 (78.69%), Query Frame = 1

Query: 1039 MEWVLKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRYWSKSDRR 1221
            MEWV+KKRPDG++Y+TRRP RN+ +K+R K++  ER   T ++D H+++ L R W+KSD+R
Sbjct:  522 MEWVVKKRPDGTRYITRRPIRNRMMKDREKKLNEERNYTTEEEDIHADLVLNRCWTKSDKR 582

HSP 2 Score: 65.855 bits (159), Expect = 3.262e-11
Identity = 33/70 (47.14%), Postives = 47/70 (67.14%), Query Frame = 1

Query:  343 YGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSNLRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVL 552
            +GLTLSY  L      E+ V+IS IE NS+A    N+R+G++IL IN+  V S++QV+ LF++  LEV L
Sbjct:  119 FGLTLSYSALSASDNSESEVYISAIEPNSVAKKEPNIRLGDQILQINNIDVHSKAQVVSLFQKCGLEVKL 188

The following BLAST results are available for this feature:

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Celegans
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Fly
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Sea Lamprey
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Yeast
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Nematostella
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDZRN4	6.718e-19	52.63	PDZ domain containing ring finger 4 [Source:HGNC S...	[more]
PDZRN3	6.904e-19	55.88	PDZ domain containing ring finger 3 [Source:HGNC S...	[more]
PDZRN3	6.904e-19	55.88	PDZ domain containing ring finger 3 [Source:HGNC S...	[more]
PDZRN3	7.165e-19	55.88	PDZ domain containing ring finger 3 [Source:HGNC S...	[more]
PDZRN4	7.875e-19	52.63	PDZ domain containing ring finger 4 [Source:HGNC S...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2


Match Name	E-value	Identity	Description
C50F7.6	1.886e-13	50.00	pep chromosome:WBcel235:IV:7720568:7722408:-1 gene...	[more]
C50F7.6	2.141e-13	48.53	pep chromosome:WBcel235:IV:7720566:7723199:-1 gene...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2


Match Name	E-value	Identity	Description
Slip1	1.739e-13	39.58	gene:FBgn0024728 transcript:FBtr0089090	[more]
Slip1	2.680e-13	39.58	gene:FBgn0024728 transcript:FBtr0310536	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
BX640588.1	5.852e-19	57.35	pep chromosome:GRCz11:CHR_ALT_CTG6_1_42:44244096:4...	[more]
pdzrn3b	6.962e-19	57.35	PDZ domain containing RING finger 3b [Source:NCBI ...	[more]
pdzrn3b	7.578e-19	57.35	PDZ domain containing RING finger 3b [Source:NCBI ...	[more]
pdzrn3b	8.237e-19	57.35	PDZ domain containing RING finger 3b [Source:NCBI ...	[more]
pdzrn4	1.160e-17	56.92	PDZ domain containing ring finger 4 [Source:ZFIN;A...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
frem2	4.280e-20	59.09	FRAS1 related extracellular matrix protein 2 [Sour...	[more]
frem2	5.685e-20	59.09	FRAS1 related extracellular matrix protein 2 [Sour...	[more]
frem2	6.026e-20	59.09	FRAS1 related extracellular matrix protein 2 [Sour...	[more]
frem2	6.097e-20	59.09	FRAS1 related extracellular matrix protein 2 [Sour...	[more]
frem2	6.851e-20	59.09	FRAS1 related extracellular matrix protein 2 [Sour...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pdzrn4	5.641e-19	52.63	PDZ domain containing RING finger 4 [Source:MGI Sy...	[more]
Pdzrn3	6.640e-19	55.88	PDZ domain containing RING finger 3 [Source:MGI Sy...	[more]
Pdzrn4	1.594e-18	52.63	PDZ domain containing RING finger 4 [Source:MGI Sy...	[more]
Pdzd4	3.320e-18	53.95	PDZ domain containing 4 [Source:MGI Symbol;Acc:MGI...	[more]
Pdzd4	3.890e-18	53.95	PDZ domain containing 4 [Source:MGI Symbol;Acc:MGI...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q69ZS0\|PZRN3_MOUSE	4.645e-18	55.88	E3 ubiquitin-protein ligase PDZRN3 OS=Mus musculus...	[more]
sp\|P68907\|PZRN3_RAT	5.170e-18	55.88	E3 ubiquitin-protein ligase PDZRN3 OS=Rattus norve...	[more]
sp\|E7FDW2\|PZR3B_DANRE	6.218e-18	57.35	E3 ubiquitin-protein ligase PDZRN3-B OS=Danio reri...	[more]
sp\|Q9UPQ7\|PZRN3_HUMAN	6.713e-18	55.88	E3 ubiquitin-protein ligase PDZRN3 OS=Homo sapiens...	[more]
sp\|Q6ZMN7\|PZRN4_HUMAN	1.105e-17	52.63	PDZ domain-containing RING finger protein 4 OS=Hom...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A2H1CRH0	1.701e-23	60.71	Uncharacterized protein OS=Fasciola hepatica OX=61...	[more]
V3ZFH3	2.300e-23	64.79	Uncharacterized protein OS=Lottia gigantea OX=2251...	[more]
A0A183A5R4	3.594e-23	63.29	Uncharacterized protein OS=Echinostoma caproni OX=...	[more]
A0A4E0S3K5	1.294e-22	60.71	PDZ domain-containing protein 4 OS=Fasciola hepati...	[more]
A0A2T7NUN7	3.448e-22	63.38	PDZ domain-containing protein OS=Pomacea canalicul...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pdzrn4	9.187e-19	57.35	PDZ domain-containing RING finger protein 4 [Sourc...	[more]
pdzrn3b	4.191e-18	54.29	PDZ domain containing ring finger 3 [Source:NCBI g...	[more]
si:ch73-162j3.4	2.201e-17	53.33	PDZ domain-containing protein 4-like [Source:NCBI ...	[more]
PDZD4	2.578e-17	55.88	PDZ domain containing 4 [Source:HGNC Symbol;Acc:HG...	[more]
pdzrn3a	9.238e-17	53.97	E3 ubiquitin-protein ligase PDZRN3 [Source:NCBI ge...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSPMAT00000000743.1	1.829e-19	60.32	pep scaffold:Pmarinus_7.0:GL478474:22919:40568:-1 ...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PDZRN4	1.164e-19	54.55	PDZ domain-containing RING finger protein 4 [Sourc...	[more]
PDZRN4	1.684e-19	54.55	PDZ domain-containing RING finger protein 4 [Sourc...	[more]
pdzrn4	4.283e-19	56.52	PDZ domain containing ring finger 4 [Source:NCBI g...	[more]
pdzrn3b	6.707e-19	57.35	PDZ domain containing ring finger 3 [Source:NCBI g...	[more]
pdzrn3b	7.162e-19	57.35	PDZ domain containing ring finger 3 [Source:NCBI g...	[more]

BLAST of E3 ubiquitin-protein ligase PDZRN3 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000070317.1	0.000e+0	99.77	SMESG000070317.1	[more]
SMESG000080284.1	3.087e-23	59.15	SMESG000080284.1	[more]
SMESG000021620.1	4.206e-16	52.46	SMESG000021620.1	[more]
SMESG000021620.1	4.324e-16	52.46	SMESG000021620.1	[more]
SMESG000021620.1	4.581e-16	52.46	SMESG000021620.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019612 ID=SMED30019612|Name=E3 ubiquitin-protein ligase PDZRN3|organism=Schmidtea mediterranea sexual|type=transcript|length=1347bp
GATCTATTTTTTCGGTCTTTCATGGATTTCATTATATTAAAGATTAATGG
AAAAGATGTGACAACATGCAGCCACGACGAGGCTGTTAAGTATTTTAATG
AAGCCCCAGACAGGTTTTTGGTAGAAATTGCCCGAAAAAATAATAGCATC
CAACTAAAGGAATCTCGAGAAATCAGATACCAATTGCCATTGATAACAGA
AGAGTTGAAGTGCGGCATCGAAAGCTCACCGATAAAAAGTTCAAAAAATA
TTCGAGATGCCAGTCAATCGTCGAGATATTCAGATACCGGTCTCGATAAT
GTCAAGATAGTGAAATTGACGAAATGCACTCGCGATCAGAGTTATGGACT
TACTCTGTCCTACGAACTTCTACAGTTGGAAAAGGAAGTTGAAACGTCAG
TTTTCATCAGTGAGATTGAGAAAAACAGTCTCGCTAGTTTTAATTCCAAT
CTTCGTGTCGGAAATGAAATTTTAGCGATCAACGATGAGCCTGTCAAAAG
CCGAAGTCAAGTGATTGATCTTTTTCGACAATCTGATCTGGAAGTTGTTT
TAACTGTTTTACAAAATTCTGAGAATCAGGATCAATATTTTCCAGAAGAT
AATTCTAATCCAAGTTTAGGCATAAATAATCAGTTATTCTTTGGTCTTCG
AGAAACCGACATTCTTTCATCTGATAACGCGTCTTCTCAGTCTGAAGACG
ACAAACTATTTGAAATAGATGTCAACAGCTCAGTCGACAGAGAAGCAATC
AAAAGCAACATGGAGTGCATTGATAAACTCATGAATAATTTGTCCTTGAC
CTACTCGTCTTTAATGAGCATAAATATTTCTGAAAATGCCGCTGTAACCA
TGGATTTACTAAAAGATATGCCTTGTCTAAAAGCGTGTTCAAAAATAAAT
GAAATCGATGAAATGGAAAAAGATTTTGATATCCACAACTTGCCAAAGAA
ATGCATACTCAATATATCAGAAAGCAGCCTTCAGAAGTCTTCCAAAAATA
TCGACAACAATAAATTATATGAAAATTTACCGGTGACTATGGAATGGGTT
TTGAAGAAACGACCTGATGGATCTAAATACGTTACACGGAGGCCAAAAAG
AAATAAATTTTTAAAAGAAAGAGCAAAACAAGTAGTTGCAGAAAGAACTG
GTGGCACAACTGACGACGATGCTCACAGTGAAATAAAATTGGGTCGCTAT
TGGAGTAAATCTGACCGTAGAAAACATTTGAGGAAATATCGTAGATTCAA
GTCTCATCAAACAAATGTAATAGAGAAATATACAACCAAACAGACACATG
ACTGTCACGATATAACTAATAAAAACAGTTTATGCAGTAATGTATCA

protein sequence of SMED30019612-orf-1

>SMED30019612-orf-1 ID=SMED30019612-orf-1|Name=SMED30019612-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=449bp
DLFFRSFMDFIILKINGKDVTTCSHDEAVKYFNEAPDRFLVEIARKNNSI
QLKESREIRYQLPLITEELKCGIESSPIKSSKNIRDASQSSRYSDTGLDN
VKIVKLTKCTRDQSYGLTLSYELLQLEKEVETSVFISEIEKNSLASFNSN
LRVGNEILAINDEPVKSRSQVIDLFRQSDLEVVLTVLQNSENQDQYFPED
NSNPSLGINNQLFFGLRETDILSSDNASSQSEDDKLFEIDVNSSVDREAI
KSNMECIDKLMNNLSLTYSSLMSINISENAAVTMDLLKDMPCLKACSKIN
EIDEMEKDFDIHNLPKKCILNISESSLQKSSKNIDNNKLYENLPVTMEWV
LKKRPDGSKYVTRRPKRNKFLKERAKQVVAERTGGTTDDDAHSEIKLGRY
WSKSDRRKHLRKYRRFKSHQTNVIEKYTTKQTHDCHDITNKNSLCSNVS

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **INTERPRO**
Term	Definition
IPR036034	PDZ_sf
IPR001478	PDZ

Vocabulary: **molecular function**
Term	Definition
GO:0005515	protein binding
GO:0004842	ubiquitin-protein transferase activity
GO:0008270	zinc ion binding
GO:0046872	metal ion binding

Vocabulary: **biological process**
Term	Definition
GO:0016567	protein ubiquitination

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR001478	PDZ domain	SMART	SM00228	pdz_new	coord: 112..189 e-value: 2.0E-8 score: 44.0
IPR001478	PDZ domain	PROSITE	PS50106	PDZ	coord: 102..189 score: 14.014
IPR036034	PDZ superfamily	GENE3D	G3DSA:2.30.42.10		coord: 77..196 e-value: 4.6E-13 score: 51.0
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 87..189
IPR036034	PDZ superfamily	SUPERFAMILY	SSF50156	PDZ domain-like	coord: 10..57
None	No IPR available	PANTHER	PTHR15545	PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4	coord: 329..424 coord: 103..327
None	No IPR available	PANTHER	PTHR15545	PDZ DOMAIN CONTAINING RING FINGER PROTEIN 3, 4	coord: 7..48
None	No IPR available	PANTHER	PTHR15545:SF8	SLO-INTERACTING PROTEIN 1	coord: 103..327 coord: 7..48
None	No IPR available	PANTHER	PTHR15545:SF8	SLO-INTERACTING PROTEIN 1	coord: 329..424
None	No IPR available	CDD	cd00992	PDZ_signaling	coord: 100..186 e-value: 8.44273E-14 score: 64.5102

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E3 ubiquitin-protein ligase PDZRN3

Zeng et. al., 2018

▻ Overview

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

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