Guanylate cyclase

Overview


Name	Guanylate cyclase
Smed ID	SMED30019592
Length (bp)	3780

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Guanylate cyclase (SMED30019592) t-SNE clustered cells

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30019592) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Guanylate cyclase (SMED30019592) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30019592) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019592

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 11

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30019592	h1SMcG0015499	SmedASXL_017932	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
protonephridia	SMED30019592	h1SMcG0015499	dd_Smed_v4_12933_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30019592	h1SMcG0015499	dd_Smed_v4_12933_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30019592	h1SMcG0015499	dd_Smed_v4_12933_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neuron	SMED30019592	h1SMcG0015499	dd_Smed_v4_12933_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30019592	h1SMcG0015499	dd_Smed_v4_12933_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019592	h1SMcG0015499	Contig7978	newmark_ests	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019592	h1SMcG0015499	Contig7978	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019592	h1SMcG0015499	Contig44378	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30019592	h1SMcG0015499	Contig44378	newmark_ests	PMID:29674431 Fincher et al., 2018
head region	SMED30019592	h1SMcG0015499	dd_Smed_v6_12933_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017

Note: Hover over icons to view figure legend

Homology

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 386.341 bits (991), Expect = 6.955e-115
Identity = 280/775 (36.13%), Postives = 416/775 (53.68%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPI-GLFKLD---DGSVLEFEFKNNKNINW-VHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX----KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR ++ V GY+  ID+ G+   ++++            +DP  G F++    +G+  E    + + +NW +   P DIP+CGF+ E    N+  +S    L ++  L +     V     +  + EKEL   LW++ R ++++ S+ E             + + +          S+  L+    N G +L  + G   +      YK   V VKRV     I +TRKV  ELK +R++   +L +F+GA  +  +  ++ E+C RGSLQD+L +  +T ++ +F  S   D+++G++FLH N  IC HG+LKSSNC+VD R+ +K+TD+G+  F       P+    +Y   L WTAPE+L                                                   ++  PP   S      Q  D+YSFG+I  E+ + +           SPKEII R +   +Q   P+RP L+L S  ++  + L++ CW E+  +RP  + I    +    E   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +    HA E+A M+L LL+ + + F I       E+L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH S      +     F +  RG +E+KGKG V T+WL+G+
Sbjct:  386 NRSFQGVTGYLK-IDSSGDRETDFSL----------WDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRV-RWEDVEPSSLE-------------RHLRSAG--------SRLTLSGRGSNYGSLLTTE-GQFQVFAKTAYYKGNLVAVKRVNRK-RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDW-MFRYSLTNDIVKGMLFLH-NGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDL---DPEQGHTVYAKKL-WTAPELL---------------------------------------------------RMASPPVRGS------QAGDVYSFGIILQEI-ALRSGVFHVEGLDLSPKEIIER-VTRGEQ--PPFRPSLALQSHLEELGL-LMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAV-RSFRI--RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944])

HSP 1 Score: 286.189 bits (731), Expect = 1.050e-79
Identity = 169/355 (47.61%), Postives = 236/355 (66.48%), Query Frame = 1

Query: 2503 NSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRP---TAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            N L +   QK+D+YSFG+I  E+     PF        SPKEI+++  V N Q +  +RP +   ++ +++ + L++ CW ++  +RP     K    RF    G   ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HA E+A M+L LL+ ++  F I      +++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNG+ALKIH S      +  L  F +  RG +E+KGKG + T+WL+G+
Sbjct:  695 NPLPTTGMQKADVYSFGIILQEIALRSGPFYLE-GLDLSPKEIVQK--VRNGQ-RPYFRPSIDR-TQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGG--TSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSS-FRI--RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039

HSP 2 Score: 115.931 bits (289), Expect = 2.120e-25
Identity = 82/242 (33.88%), Postives = 125/242 (51.65%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKS------CCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEIL 2325
            EKEL  +LW+I R +E+ F N E   K +              + L     S   L  +        N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ FLH N  I  HG LKSSNC+VDSR+ +K+TD+G+  F +  + +PD    +Y   L WTAPE+L
Sbjct:  484 EKELASMLWRI-RWEELQFGNSERYHKGA-----------GSRLTLSLRGSSYGSLMTAHGKYQIFANTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDW-MFRYSLINDLVKGMAFLH-NSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRS--TAEPDDSHALYAKKL-WTAPELL 692

[Close]

BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691])

HSP 1 Score: 254.218 bits (648), Expect = 9.244e-69
Identity = 163/358 (45.53%), Postives = 215/358 (60.06%), Query Frame = 1

Query: 2494 PNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-LSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVL-FGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVE-RGVIEVKGKGSVNTFWLIGK 3555
            P  + L S +    D+YSF +I  E+     PF + +  +Q    EII RL     +   P    +        + + L+K CW E A QRPT   I+N+FK    G+K N+++ M   +  Y+ NLE  + +RTEEL  EK++ E+LL QMLP  VAE L++   VE E FD V++YFSDIVGFT ++    P EV++LLN LYT FD II + +VYKVETIGD+YMV SGLP +    HA E+ANMSL +L  +               +++RIGLHSGP  AGVVG   PRYCLFGDTVN ASRMES G   +IH S + +  +  L+E + VE RG  E+KGKG+  TFWLIGK
Sbjct:  721 PRGSRLGSFA---GDVYSFAIIMQEVMVRGTPFCMMDLPAQ----EIINRL-----KKPPPVYRPVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVG---TFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGK 1063

HSP 2 Score: 81.6481 bits (200), Expect = 6.910e-15
Identity = 68/238 (28.57%), Postives = 118/238 (49.58%), Query Frame = 1

Query: 1645 KIDRLKEIDFSNHELL--EKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKS---CCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLA-----ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            +I++++ I   N  LL  E  +FI  P           + F+  S+    +S     + G +    +  SN+   +Y+   V +K+  FSL       SI  +     + ++++ + N+N  +G   +     +V EFC RGSL+D+L +  +  ++ +F SS   D+I+G+ +LH    +  HG LKS NC+VD R+ +K+TD+G  + L  +     + E      L WTAPE+LR
Sbjct:  493 RINKIQLIKGPNRILLTLEDVTFIN-PHFGSKRGSRASVSFQITSEVQSGRSPRLSFSSGSLTPATYENSNI--AIYEGDWVWLKK--FSLGDFGDLKSIKSRASDVFEMMKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDW-MFKSSLLLDLIKGMKYLHHREFV--HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLR---LSEEESSMEELLWTAPELLR 719

[Close]

BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689])

HSP 1 Score: 238.424 bits (607), Expect = 1.250e-63
Identity = 147/345 (42.61%), Postives = 210/345 (60.87%), Query Frame = 1

Query: 2530 KSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFK-VLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVE-RGVIEVKGKGSVNTFWLIGK 3555
              D++S  +I  E+     P+      + +P+E+++R+     +   P    L  + +   + I L+K CW E    RP+    ++ FK +  G K N+++ M   +  Y+ NLE  + +RTEEL  EK++ + LL QMLP  VAE L+    VE E F+ V++YFSDIVGFT ++    P EV++LLN LYT FD II + +VYKVETIGD+YMV SGLP +  + HA E+ANMSL +L  +   F +         +++RIGLHSGPC AGVVG   PRYCLFGDTVN ASRMES G   +IH + + +  +  L+  + VE RG  E+KGKG+ +TFWL+G+
Sbjct:  726 AGDVFSLAIIMQEVVCRSAPY---AMLELTPEEVVQRV-----RSPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGT-FRM--RHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGR 1059

HSP 2 Score: 85.5001 bits (210), Expect = 4.601e-16
Identity = 57/173 (32.95%), Postives = 87/173 (50.29%), Query Frame = 1

Query: 1849 LCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMG----------AIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTY--VSPQPDTPEYMYFLSLFWTAPEILRD 2331
            + +Y+   V +K+      I+I    K     L+E+ + N+  ++G          A +   +  VV E C RGSLQD+L   ++  ++ +F SS   D+I+G+ +LH       HG LKS NC+VD R+ +K+TD G    L    V P+P   E        WTAPE+LRD
Sbjct:  552 IGVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDW-MFKSSLLLDLIKGIRYLHHR--GVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRAE-----DQLWTAPELLRD 716

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688])

HSP 1 Score: 236.498 bits (602), Expect = 4.243e-63
Identity = 145/357 (40.62%), Postives = 218/357 (61.06%), Query Frame = 1

Query: 2527 QKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQID---LIKLCWQENATQRPTAKVIYNRFKVLFG---EKKN--LVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNE--FHIVERGVIEVKGKGSVNTFWLIGKLEQ 3564
            QK D+YS+G+I  E+   +  F +  S ++  ++I R   V N     P+RP L  L   ++K+++   L+K CW+E+  +RP  K I      +FG   ++KN   ++ +  ++ LY++NLE  V +RT+  + E+ + + L + +LP  V + L++   VE E ++ V+IYFSDIVGFT +  + +P EV+++LN +Y SFD I+D+ +VYKVETIGD+YMV SGLP +  + HA ++A M+L +L  +        E      + +RIG+HSGPC AGVVG + PRYCLFGDTVN ASRMES G  L+IH S + I  IL   E  F    RG   +KG+G+  T+WL G  +Q
Sbjct:  659 QKGDVYSYGIIAQEIILRKETFYT-LSCRDRNEKIFR---VENSNGMKPFRPDL-FLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMG---TFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTI-AILKRTECQFLYEVRGETYLKGRGNETTYWLTGMKDQ 1006

HSP 2 Score: 88.9669 bits (219), Expect = 4.543e-17
Identity = 62/166 (37.35%), Postives = 85/166 (51.20%), Query Frame = 1

Query: 1852 CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYP-------VFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            C Y  + V++K +  +   + T K K EL  L +I Y NL KF G +      + V E+C+RGSL++VL     T  YP        F  S  +D+ +G+ +LH +     HG LKS+NC+VDSR  VK+TDFG    L    P+ D           WTAPE LR
Sbjct:  506 CKYDKKRVILKDLKHNDG-NFTEKQKIELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLND---TISYPDGTFMDWEFKISVLYDIAKGMSYLHSS-KTEVHGRLKSTNCVVDSRMVVKITDFGCNSIL---PPKKD----------LWTAPEHLR 653

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-12 (Receptor-type guanylate cyclase gcy-12 [Source:UniProtKB/Swiss-Prot;Acc:Q19187])

HSP 1 Score: 437.187 bits (1123), Expect = 1.649e-129
Identity = 357/1175 (30.38%), Postives = 580/1175 (49.36%), Query Frame = 1

Query:  283 ISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDK---ENEFI-----LQNCLSVLKAHNITILH-NKLVMSPAIYGSANN--KFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLT---------DTG-----------NYFVVSLVLRLEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPP-----FNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILK----NPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQL-----IINANG------EMKIDPIGLF--KLDDGSVLEFEFKNNKNINWVH-DIPRDIPECGFNGEICRTNE----KXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDW------GTSNLILCMYKNQEVVVKRV-YFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF---LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-----LSNYSSQNSPKEI---IRRLI--VLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE--KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPT--QFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNE-FHIVERGVIEVKGKGSVNTFWLIGK 3555
            +SGAL  A+ +IN        + L+P+ YQ+   F  T G  ++S +   +   +      IGP++ C+TEA +A + N+ +IS+ C D  ++ D   Y TF RT P    +    +S +K++ W   S++    K   +NE       +    +  + H   I++ +KL  S     S  +       +++T Q+TRIY+   +      +L  + E GLT         DT            N+F+ + +  L    D+   N   D + L        I P    +K  S +F  F  +       F V+  D    +     + YLYDAV LYA  +  +++    + S     DG  +   ++N+ Y+S+ G+   ID +G + GN+++        I+N +       +  +D   +F    D   +   +FK+++ I W+  + P D P CGF+GE CR         + + + + +  +++   +   I+S+R+EKEL  ++WKID                 +  R  +  + N        E +  L+            P W      GT    L  YK   V +K + Y      +TR+ KKEL+ +R++++ N+N F+G I+      VV E+C +GSL D+L +  L  ++ ++++SF  D+++G++++H++ ++  HG+LKS+NCL+ SRWT+++ DFG+RE    + Y S       Y  + +  WTAPE +                                  +N S            + I  PP P         K+D YSFG+IF+E+ + + P+       + + + +PK+     R L+   +   +  PY RP  S L   +  + +++  CW  +  QRP  K I N+ K LF +  K+N+++ M   M  Y   LE  V +RT EL++E+++++ LL +MLP  VAEQL   + V  EAF  V+IYFSDIVGFT ++G  +P EV+  LN+LYT FD II  ++VYKVETIGD+YMVVSG+P     + HA ++A M++ +L  + + F IP      E L +RIG+H+GPC AGVVG   PRY LFGDTVN ASRMESNGEAL+IHCS +    +  +++ F + ERG + +KGKG + T+WL G+
Sbjct:  141 VSGALVAAIVEINQ------DKDLIPA-YQLKYVFGNTCGNDSHSTRLFME-HWQAGARVFIGPEKNCKTEAAMAASQNLPIISYRCNDQDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYDVKKGQVKNELFETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTTRIYLTFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYLHHSWDA---NNSSDRKMLDYARSALSIIPTP--VKLNSQRFYNFWKKAGDYMHHFGVQKADNLKGNRI---ACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERGNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLPNLQFKSSR-IQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTLNYIRSRRFEKELS-MIWKID----------------PYEVRRVVGGVNN--------ESTASLMQSDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDH-MYVASFVDDLVKGMVYIHDS-ELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS------SYNIWENFLWTAPEAM---------------------------------TINGS------------LAISNPPTP---------KADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVK-EVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAV-RSFSIPHRSC--EPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGR 1207

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 343.199 bits (879), Expect = 7.416e-99
Identity = 220/560 (39.29%), Postives = 318/560 (56.79%), Query Frame = 1

Query: 1906 ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF--LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-LSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ------IDLIKLCWQENATQRPTAKVIYNRFKVLF--GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIG 3552
            + ++R    ELK ++++ + ++ +F GA I+     VV E+C +GSL+D+L + K+  +  +   S   D+++GL FLH N +I  HG LKSSNC+VDSR+ +K+TDFG+     L  ++ + +  E+ Y+  + WTAPE+LR                                D NA                  PP       +  QK DIYSF +I +E+   +  F L N     SP EI++R+     + + P RP +S     +         + L+  CW E+  +RP    +    + L    E  NLV+ + ++M  Y  NLE  V +RT+E   EKK+ EELL+Q+LP  +A+ L   + V+AE++D V+IYFSDIVGFT L+   +P +V+ LLN LY +FD ++DNF VYKVETIGD+YMVVSGLP + D+HA ++A MSL LL ++ K FVI    +  E+LKLRIG+HSG   AGVVG++ PRYCLFGDTVN +SRMESNG  LKIH S+     ++    F +  RG +E+KGKG   T+WL G
Sbjct:  709 LDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELD-KLMKYSLLHDLVKGLFFLH-NSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLE-EIGEHAYYKKMLWTAPELLR--------------------------------DSNA------------------PP-------MGTQKGDIYSFAIILHEMMFRKGVFALEN--EDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKV-KNFVIRHRPH--EQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 343.584 bits (880), Expect = 7.968e-99
Identity = 220/560 (39.29%), Postives = 318/560 (56.79%), Query Frame = 1

Query: 1906 ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF--LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-LSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ------IDLIKLCWQENATQRPTAKVIYNRFKVLF--GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIG 3552
            + ++R    ELK ++++ + ++ +F GA I+     VV E+C +GSL+D+L + K+  +  +   S   D+++GL FLH N +I  HG LKSSNC+VDSR+ +K+TDFG+     L  ++ + +  E+ Y+  + WTAPE+LR                                D NA                  PP       +  QK DIYSF +I +E+   +  F L N     SP EI++R+     + + P RP +S     +         + L+  CW E+  +RP    +    + L    E  NLV+ + ++M  Y  NLE  V +RT+E   EKK+ EELL+Q+LP  +A+ L   + V+AE++D V+IYFSDIVGFT L+   +P +V+ LLN LY +FD ++DNF VYKVETIGD+YMVVSGLP + D+HA ++A MSL LL ++ K FVI    +  E+LKLRIG+HSG   AGVVG++ PRYCLFGDTVN +SRMESNG  LKIH S+     ++    F +  RG +E+KGKG   T+WL G
Sbjct:  730 LDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELD-KLMKYSLLHDLVKGLFFLH-NSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLE-EIGEHAYYKKMLWTAPELLR--------------------------------DSNA------------------PP-------MGTQKGDIYSFAIILHEMMFRKGVFALEN--EDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKV-KNFVIRHRPH--EQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 343.584 bits (880), Expect = 1.207e-98
Identity = 220/560 (39.29%), Postives = 318/560 (56.79%), Query Frame = 1

Query: 1906 ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF--LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-LSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ------IDLIKLCWQENATQRPTAKVIYNRFKVLF--GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIG 3552
            + ++R    ELK ++++ + ++ +F GA I+     VV E+C +GSL+D+L + K+  +  +   S   D+++GL FLH N +I  HG LKSSNC+VDSR+ +K+TDFG+     L  ++ + +  E+ Y+  + WTAPE+LR                                D NA                  PP       +  QK DIYSF +I +E+   +  F L N     SP EI++R+     + + P RP +S     +         + L+  CW E+  +RP    +    + L    E  NLV+ + ++M  Y  NLE  V +RT+E   EKK+ EELL+Q+LP  +A+ L   + V+AE++D V+IYFSDIVGFT L+   +P +V+ LLN LY +FD ++DNF VYKVETIGD+YMVVSGLP + D+HA ++A MSL LL ++ K FVI    +  E+LKLRIG+HSG   AGVVG++ PRYCLFGDTVN +SRMESNG  LKIH S+     ++    F +  RG +E+KGKG   T+WL G
Sbjct:  768 LDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELD-KLMKYSLLHDLVKGLFFLH-NSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLE-EIGEHAYYKKMLWTAPELLR--------------------------------DSNA------------------PP-------MGTQKGDIYSFAIILHEMMFRKGVFALEN--EDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKV-KNFVIRHRPH--EQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 316.62 bits (810), Expect = 4.102e-94
Identity = 203/516 (39.34%), Postives = 294/516 (56.98%), Query Frame = 1

Query: 1906 ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF--LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-LSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ------IDLIKLCWQENATQRPTAKVIYNRFKVLF--GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNG 3420
            + ++R    ELK ++++ + ++ +F GA I+     VV E+C +GSL+D+L + K+  +  +   S   D+++GL FLH N +I  HG LKSSNC+VDSR+ +K+TDFG+     L  ++ + +  E+ Y+  + WTAPE+LR                                D NA                  PP       +  QK DIYSF +I +E+   +  F L N     SP EI++R+     + + P RP +S     +         + L+  CW E+  +RP    +    + L    E  NLV+ + ++M  Y  NLE  V +RT+E   EKK+ EELL+Q+LP  +A+ L   + V+AE++D V+IYFSDIVGFT L+   +P +V+ LLN LY +FD ++DNF VYKVETIGD+YMVVSGLP + D+HA ++A MSL LL ++ K FVI    +  E+LKLRIG+HSG   AGVVG++ PRYCLFGDTVN +SRMESNG
Sbjct:  141 LDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELD-KLMKYSLLHDLVKGLFFLH-NSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLE-EIGEHAYYKKMLWTAPELLR--------------------------------DSNA------------------PP-------MGTQKGDIYSFAIILHEMMFRKGVFALEN--EDLSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDDHANQIAQMSLSLLHKV-KNFVIRHRPH--EQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNG 591

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792)

HSP 1 Score: 575.859 bits (1483), Expect = 0.000e+0
Identity = 403/1151 (35.01%), Postives = 596/1151 (51.78%), Query Frame = 1

Query:  184 RDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL--EAISDSAFGNI---QVDSRSLRNFVIISHIEPEGQL-IKTESSKFKYFMSRPPFNVESQDK--SNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGE----MKIDPIGLFKLDDGSVLEFE-----FKNNKNINWVHDI-PRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYF--LSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQ 3564
            R  +  +  +GY+  ++  P     +Y R G  ISGA++ AV ++N+    +   SL     Q  V   ETYGE   SI+  A +  ++ V A IGPQETC  E  +A AFN+ MIS++CT    +  +  + TF RTRP  + ++  +V+ L  F W  VS +  DD   ++  + +  LS L    ++I   +   +   +G  +N F  +VE T+ +TRIY+ +G  +E  GL+++L  +G+   G+YFVV + +     A  +     +    V+  +++ F     I P   +   T +++   +M RPPFN  +             E++YLYDAV LYA  +  +L   S G P++G  +   +    Y+S  GY  +ID  G+A GNYTV       NG     + + P+G F   + S+          K    I+WV    P   P CGF GE C  N             L+L+  VS  + ++ RYE+EL+ LLWKID  +E+    +E  ++    TR     I    V L    D+ F        IG               +YK Q   +K+V    ++ ITR++KKELK LR+  + N+  F+GA  +  +  ++ E+C RGSL+D+L +  +  +  +F++S   D+IRG+I+LH++P I FHG L +SNCLVDSRW VKLTDFG+  F   +       ++M    L L + APE+LR          Q   SL +G                                               Q+ D YSFG++ YE+H  + PF     +  +P + +++++   D    PYRP L  L        + ++ CW E    RP  K I  + + L  G + N+ + M   M  Y  NLE  V  RT++L+EEKK+ + LL++MLP  VA+QL++  +V+ E ++ VSIYFSDIVGFT ++  C+P +V++ LN LYT FD II +++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LL  +++ F I        RL LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES+G  LKIHCS      +  L  +H  ERGVI +KGKG   T+WL+G+ E+
Sbjct:   34 RPTHGEVFTLGYLTASQRRPGN--LDYNRPGLTISGAISLAVEEVNAGRLRDRGHSL-----QFVV--AETYGEEVVSIRQTAALWTQQ-VAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLD--SGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID-FREVQIHENEREQQSQKQTRSTHPLIRTSQVSLSSNPDADFRYTTIFTPIG---------------LYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDN-MFIASMVADIIRGVIYLHDSP-IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLR----------QGPSSLVMGT----------------------------------------------QRGDAYSFGILLYEMHVRRGPF---GETGLTPMQCLQKVLQPQDYLN-PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSE-FKI--RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1088

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304791)

HSP 1 Score: 575.089 bits (1481), Expect = 0.000e+0
Identity = 403/1153 (34.95%), Postives = 596/1153 (51.69%), Query Frame = 1

Query:  184 RDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL--EAISDSAFGNI---QVDSRSLRNFVIISHIEPEGQL-IKTESSKFKYFMSRPPFNVESQDK--SNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGE----MKIDPIGLFKLDDGSVLEFE-------FKNNKNINWVHDI-PRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYF--LSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQ 3564
            R  +  +  +GY+  ++  P     +Y R G  ISGA++ AV ++N+    +   SL     Q  V   ETYGE   SI+  A +  ++ V A IGPQETC  E  +A AFN+ MIS++CT    +  +  + TF RTRP  + ++  +V+ L  F W  VS +  DD   ++  + +  LS L    ++I   +   +   +G  +N F  +VE T+ +TRIY+ +G  +E  GL+++L  +G+   G+YFVV + +     A  +     +    V+  +++ F     I P   +   T +++   +M RPPFN  +             E++YLYDAV LYA  +  +L   S G P++G  +   +    Y+S  GY  +ID  G+A GNYTV       NG     + + P+G F   + S+            K    I+WV    P   P CGF GE C  N             L+L+  VS  + ++ RYE+EL+ LLWKID  +E+    +E  ++    TR     I    V L    D+ F        IG               +YK Q   +K+V    ++ ITR++KKELK LR+  + N+  F+GA  +  +  ++ E+C RGSL+D+L +  +  +  +F++S   D+IRG+I+LH++P I FHG L +SNCLVDSRW VKLTDFG+  F   +       ++M    L L + APE+LR          Q   SL +G                                               Q+ D YSFG++ YE+H  + PF     +  +P + +++++   D    PYRP L  L        + ++ CW E    RP  K I  + + L  G + N+ + M   M  Y  NLE  V  RT++L+EEKK+ + LL++MLP  VA+QL++  +V+ E ++ VSIYFSDIVGFT ++  C+P +V++ LN LYT FD II +++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LL  +++ F I        RL LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES+G  LKIHCS      +  L  +H  ERGVI +KGKG   T+WL+G+ E+
Sbjct:   34 RPTHGEVFTLGYLTASQRRPGN--LDYNRPGLTISGAISLAVEEVNAGRLRDRGHSL-----QFVV--AETYGEEVVSIRQTAALWTQQ-VAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLD--SGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID-FREVQIHENEREQQSQKQTRSTHPLIRTSQVSLSSNPDADFRYTTIFTPIG---------------LYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDN-MFIASMVADIIRGVIYLHDSP-IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLR----------QGPSSLVMGT----------------------------------------------QRGDAYSFGILLYEMHVRRGPF---GETGLTPMQCLQKVLQPQDYLN-PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSE-FKI--RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1090

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302487)

HSP 1 Score: 571.237 bits (1471), Expect = 0.000e+0
Identity = 405/1164 (34.79%), Postives = 598/1164 (51.37%), Query Frame = 1

Query:  184 RDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL--EAISDSAFGNI---QVDSRSLRNFVIISHIEPEGQL-IKTESSKFKYFMSRPPFNVESQDK--SNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGE----MKIDPIGLFKLDDGSVLEFE-----FKNNKNINWVHDI-PRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITR----------PPIKE---IENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYF--LSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQ 3564
            R  +  +  +GY+  ++  P     +Y R G  ISGA++ AV ++N+    +   SL     Q  V   ETYGE   SI+  A +  ++ V A IGPQETC  E  +A AFN+ MIS++CT    +  +  + TF RTRP  + ++  +V+ L  F W  VS +  DD   ++  + +  LS L    ++I   +   +   +G  +N F  +VE T+ +TRIY+ +G  +E  GL+++L  +G+   G+YFVV + +     A  +     +    V+  +++ F     I P   +   T +++   +M RPPFN  +             E++YLYDAV LYA  +  +L   S G P++G  +   +    Y+S  GY  +ID  G+A GNYTV       NG     + + P+G F   + S+          K    I+WV    P   P CGF GE C  N             L+L+  VS  + ++ RYE+EL+ LLWKID  +E+    +E  ++    TR          PP      I    V L    D+ F        IG               +YK Q   +K+V    ++ ITR++KKELK LR+  + N+  F+GA  +  +  ++ E+C RGSL+D+L +  +  +  +F++S   D+IRG+I+LH++P I FHG L +SNCLVDSRW VKLTDFG+  F   +       ++M    L L + APE+LR          Q   SL +G                                               Q+ D YSFG++ YE+H  + PF     +  +P + +++++   D    PYRP L  L        + ++ CW E    RP  K I  + + L  G + N+ + M   M  Y  NLE  V  RT++L+EEKK+ + LL++MLP  VA+QL++  +V+ E ++ VSIYFSDIVGFT ++  C+P +V++ LN LYT FD II +++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LL  +++ F I        RL LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES+G  LKIHCS      +  L  +H  ERGVI +KGKG   T+WL+G+ E+
Sbjct:   34 RPTHGEVFTLGYLTASQRRPGN--LDYNRPGLTISGAISLAVEEVNAGRLRDRGHSL-----QFVV--AETYGEEVVSIRQTAALWTQQ-VAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLD--SGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID-FREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIG---------------LYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDN-MFIASMVADIIRGVIYLHDSP-IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLR----------QGPSSLVMGT----------------------------------------------QRGDAYSFGILLYEMHVRRGPF---GETGLTPMQCLQKVLQPQDYLN-PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSE-FKI--RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1101

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BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302488)

HSP 1 Score: 570.466 bits (1469), Expect = 0.000e+0
Identity = 405/1166 (34.73%), Postives = 598/1166 (51.29%), Query Frame = 1

Query:  184 RDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL--EAISDSAFGNI---QVDSRSLRNFVIISHIEPEGQL-IKTESSKFKYFMSRPPFNVESQDK--SNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGE----MKIDPIGLFKLDDGSVLEFE-------FKNNKNINWVHDI-PRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITR----------PPIKE---IENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYF--LSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQ 3564
            R  +  +  +GY+  ++  P     +Y R G  ISGA++ AV ++N+    +   SL     Q  V   ETYGE   SI+  A +  ++ V A IGPQETC  E  +A AFN+ MIS++CT    +  +  + TF RTRP  + ++  +V+ L  F W  VS +  DD   ++  + +  LS L    ++I   +   +   +G  +N F  +VE T+ +TRIY+ +G  +E  GL+++L  +G+   G+YFVV + +     A  +     +    V+  +++ F     I P   +   T +++   +M RPPFN  +             E++YLYDAV LYA  +  +L   S G P++G  +   +    Y+S  GY  +ID  G+A GNYTV       NG     + + P+G F   + S+            K    I+WV    P   P CGF GE C  N             L+L+  VS  + ++ RYE+EL+ LLWKID  +E+    +E  ++    TR          PP      I    V L    D+ F        IG               +YK Q   +K+V    ++ ITR++KKELK LR+  + N+  F+GA  +  +  ++ E+C RGSL+D+L +  +  +  +F++S   D+IRG+I+LH++P I FHG L +SNCLVDSRW VKLTDFG+  F   +       ++M    L L + APE+LR          Q   SL +G                                               Q+ D YSFG++ YE+H  + PF     +  +P + +++++   D    PYRP L  L        + ++ CW E    RP  K I  + + L  G + N+ + M   M  Y  NLE  V  RT++L+EEKK+ + LL++MLP  VA+QL++  +V+ E ++ VSIYFSDIVGFT ++  C+P +V++ LN LYT FD II +++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LL  +++ F I        RL LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES+G  LKIHCS      +  L  +H  ERGVI +KGKG   T+WL+G+ E+
Sbjct:   34 RPTHGEVFTLGYLTASQRRPGN--LDYNRPGLTISGAISLAVEEVNAGRLRDRGHSL-----QFVV--AETYGEEVVSIRQTAALWTQQ-VAAYIGPQETCVHEGRMAAAFNLPMISYYCTHRDPSNKAD-FPTFARTRPPDTQISKSVVALLLAFNWTQVSFLYLDDASGQYQPVAETILSTLTDAGVSIRDIRTWNTIYHHGFMDNPFEALVEQTYANTRIYLILGHYYEHVGLMVSLQRRGILSKGDYFVVGIDIEQYDPAKPEKYLRGLLLEDVEPLAVQAFQSYLGIVPTASVSFATFANEVNKYMERPPFNFPNPLGPFGGVKQISAEAAYLYDAVHLYAKALMEVLD--SGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDWVGGTRPAAAPRCGFGGEKC-VNYTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKID-FREVQIHENEREQQSQKQTRHLLNHLPRRLPPQSTHPLIRTSQVSLSSNPDADFRYTTIFTPIG---------------LYKGQLYAIKKVR-KKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDN-MFIASMVADIIRGVIYLHDSP-IRFHGALCTSNCLVDSRWVVKLTDFGLFAFKQGIEDSSTDMQHMSAKCLKLLYRAPELLR----------QGPSSLVMGT----------------------------------------------QRGDAYSFGILLYEMHVRRGPF---GETGLTPMQCLQKVLQPQDYLN-PYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRKGMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSE-FKI--RHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDEE 1103

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BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG42637 (gene:FBgn0261360 transcript:FBtr0302277)

HSP 1 Score: 461.455 bits (1186), Expect = 5.966e-139
Identity = 372/1185 (31.39%), Postives = 597/1185 (50.38%), Query Frame = 1

Query:  193 NQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEFILQNCLSVLK----AHNITILH------NKLVMSPAIYGSANNKF-NKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVD--------------SRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQD---KSNTS-YAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXX---------XNRYYKSVFGYMNHIDNKGEAYGNYTV---------NQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVH--DIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXX---XXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLS-NYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ---IDLIKLCWQENATQRPTAKVIYNRFKVLFGEK-KNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVE-RGVIEVKGKGSVNTFWLIGKLEQNI 3570
            ++T++ +GY+  T    D++ R     G  ISGALT A++++N         +LLP+ Y + + + +T G+   + +A+ +M +   +  I GP+  C  EA ++ + NI MIS+ C +      +    TF RT P  + +   L++ L+ + WN  SI+  D      +      +LK      N+TI H      N++     +     + +  ++V+NT   TRIYVF+G+   +   + ++   GL   G Y V+ + + + +  ++     +VD              ++  R+ ++++   P    I+  + + + + S+PPFN+E      +SN S +  + ++YLYD+V LYA  V  +L+  +     D +                NR Y S+ G    ID  G++ GN++V         N   +  N  M   P+  F   +    E++  N  +I+W    + P D P CGF  E+C+ ++   +  V+  +L +L      ++  + +  + E E+E LLWKID  +   +S +E++   S ++                      + A+S    G      + TS   L   +   V +K + F     I+R++ KE++ LRE+ + N+N F+GA +E     +V ++C +GSL D++ +  + K   +F++S   D+I+G+I++H N  + +HG+LKSSNC+V SRW +++TDFG+ E L   +      E+ ++ +  W APE+LR+ I    H +Q                   K DV A                                     F +I YE+ S + PF   N+     PKEI+  +  L  + + P+RP++  +   +      +  I+ CW E+  +RP   VI NR K + G K KN+++ M E M  Y  NLE  V +RT  L EEK + E+LL++MLP  VAE+L   + VE  ++D V+IYFSDIVGFT ++   +P +V+N LN LYT FD+II  ++VYKVETIGD+YMVVSGLP +  D HA E+A+M+L LL  + +  +       NE LKLRIG+H+GP  AGVVG   PRYCLFGDTVN ASRMESNGEALKIH S    L +  L   +I E RG++ +KGKG V T+WL G  E  I
Sbjct:   22 HRTVLTVGYL--TALTGDLKTR----QGLAISGALTMALDEVNK------DPNLLPNVY-LDLRWNDTKGDTVLATKAITEM-ICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAE----YRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYED------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQF-TKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMV--PVAYFHQGEEHP-EYKLING-SIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVS---------------------LMSAQS---YGSRWTNQFVTSTGRL---RGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDI-KLDDLFIASLIHDLIKGMIYIH-NSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHE-LRQCAENESIGEHQHYRNQLWRAPELLRNHI----HGSQ-------------------KGDVYA-------------------------------------FAIIMYEIFSRKGPFGQINF----EPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRI---AHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 414.846 bits (1065), Expect = 2.392e-125
Identity = 359/1156 (31.06%), Postives = 562/1156 (48.62%), Query Frame = 1

Query:  190 RNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKM-SVEKKV----WAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENE-----FILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMA-LYEKGLT-DTGNYFVVSLVLR-LEAISDSAFGNIQVDS----RSLRNFVIISHIEPEGQLIKTESSKFKY-FMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-----GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            +N T+ +I  +  TEYP       + R    +  AL +A+ K+NS       +  L + Y + + F  +  +      +VA + +V+ K     WA IGP   C   +     F         T          YS+     P    L  +++   + F W+  +++  +D +N+     F ++   + ++  NIT   + LV +         ++++++ +     R+ V++   +E F  LM   + +G   +   +F + L  R L++     +     D      + ++  I+++ EP+    K   SK K   M    FNVE       S   + S   +D V+LY+  +   +     GS   G ++ K + NR Y  V G +  +D  G+   ++ +  +     G+ +I       + +GS  +   +    ++W+    P DIPECGF  +    + +T      I + +  + I+++ V+ F+ +  + E EL   LW++   ++I  SN E + +                 C      S+  ++    N G +L  D          Y    +   +      I +TRKV  ELK +R++   +L +F+GA I+  +  ++ E+C RGSLQD++ S  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VDSR+ +K+TD+G+  F  +     D     Y   L WTAPE+                                                   ++   PP      +   QK D+YSFG+I  EL   +  F        SPKEII R++    + + PY RP L   S +++    L+  CW E+  +RP     +++ KVL      G   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P EV+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LLE +   F I      N +L+LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH SEA    +   N F +  RG +E+KGKG + T+WL+G++  N
Sbjct:   45 KNITLAVILPLHNTEYP-----WAWPR----VGPALYWALEKVNS-------DPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGP--GCDYSSSPVARFTTHWEVPMITSGARALGFNLYSSITNIGPTHKKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITA--DDLVFNE---DEEPLRYDELLRDISHKARV-VYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVED------SLMNLISGSFHDGVMLYSHALNDTMDRS--GSRPPGDVVNKRMWNRTYHGVTGLV-QLDENGDREIDFALWDMTDTKTGDYQI-----VSVYNGSQKQMILEPGMKVHWLKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRV-HWEDIQMSNTEKVLR---------------RAC------SKLTISLRGSNYGSLLTMDGNFQIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDW-MFRYSLINDIVKGMAFLH-NSVIVSHGNLKSSNCVVDSRFVLKITDYGLESF--HKDSNLDDVHAFYARQL-WTAPEL---------------------------------------------------LRADNPP------ACGTQKGDVYSFGIILQELALLKGVFYLEGPCL-SPKEIIERVV----EGRWPYLRPLLCPQSHSEEMG-QLMLRCWSEDVNERPD----FSQIKVLLRKNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAV-HSFRI--RHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEISSN 1065

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Query:  190 RNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKM-SVEKKV----WAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENE-----FILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMA-LYEKGLT-DTGNYFVVSLVLR-LEAISDSAFGNIQVDS----RSLRNFVIISHIEPEGQLIKTESSKFKY-FMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-----GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            +N T+ +I  +  TEYP       + R    +  AL +A+ K+NS       +  L + Y + + F  +  +      +VA + +V+ K     WA IGP   C   +     F         T          YS+     P    L  +++   + F W+  +++  +D +N+     F ++   + ++  NIT   + LV +         ++++++ +     R+ V++   +E F  LM   + +G   +   +F + L  R L++     +     D      + ++  I+++ EP+    K   SK K   M    FNVE       S   + S   +D V+LY+  +   +     GS   G ++ K + NR Y  V G +  +D  G+   ++ +  +     G+ +I       + +GS  +   +    ++W+    P DIPECGF  +    + +T      I + +  + I+++ V+ F+ +  + E EL   LW++   ++I  SN E + +                 C      S+  ++    N G +L  D          Y    +   +      I +TRKV  ELK +R++   +L +F+GA I+  +  ++ E+C RGSLQD++ S  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VDSR+ +K+TD+G+  F  +     D     Y   L WTAPE+                                                   ++   PP      +   QK D+YSFG+I  EL   +  F        SPKEII R++    + + PY RP L   S +++    L+  CW E+  +RP     +++ KVL      G   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P EV+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LLE +   F I      N +L+LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH SEA    +   N F +  RG +E+KGKG + T+WL+G++  N
Sbjct:   45 KNITLAVILPLHNTEYP-----WAWPR----VGPALYWALEKVNS-------DPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGP--GCDYSSSPVARFTTHWEVPMITSGARALGFNLYSSITNIGPTHKKLGEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITA--DDLVFNE---DEEPLRYDELLRDISHKARV-VYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPWARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVED------SLMNLISGSFHDGVMLYSHALNDTMDRS--GSRPPGDVVNKRMWNRTYHGVTGLV-QLDENGDREIDFALWDMTDTKTGDYQI-----VSVYNGSQKQMILEPGMKVHWLKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRV-HWEDIQMSNTEKVLR---------------RAC------SKLTISLRGSNYGSLLTMDGNFQIYAKTGYYKGNITAIKYVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDW-MFRYSLINDIVKGMAFLH-NSVIVSHGNLKSSNCVVDSRFVLKITDYGLESF--HKDSNLDDVHAFYARQL-WTAPEL---------------------------------------------------LRADNPP------ACGTQKGDVYSFGIILQELALLKGVFYLEGPCL-SPKEIIERVV----EGRWPYLRPLLCPQSHSEEMG-QLMLRCWSEDVNERPD----FSQIKVLLRKNNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAV-HSFRI--RHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGEISSN 1065

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 382.874 bits (982), Expect = 3.685e-116
Identity = 305/862 (35.38%), Postives = 449/862 (52.09%), Query Frame = 1

Query: 1024 IISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKD---GMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE--ICR--TNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPE-YMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLE 3561
            I++++EP+ Q  K   +  K    R  FN    D    S   + S   YD ++LY   +     N SL    +   G  + K + NR Y  V G +  ID  G+   ++ +  +     G+ +I  + ++   +G+  E        I W    +P D+P CGF  E   CR  T      I + LF++LI++  V+ F+ +  + EKEL   LW+I    +I  S+   LEK    T                   S+  L+    N G +L  D          Y    +V  +      + +TRKV  ELK +R++   +L +F+GA I+  +  +V E+C RGSLQ++L +  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VD+R+ +K+TD+G    L+ +  + DT + + Y+    W APE+                                             S +E F     PP          QK D+YSFG+I  E+   +  F        SPKEI+ R+ +     + PY RP L+  + +++    L++ CW E  + RP     ++   VL  +     + N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + K F I      +E+LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMESNGE LKIH S A    +   N F +  RG +E+KGKG + T+WL+G+++
Sbjct:   67 ILTYLEPQNQEYKDFVTDLKSDAKRM-FNFTVDD----SLMNIISGGFYDGLMLYCHAL-----NESLSDSHERPSGESVSKRMWNRTYYGVTGLV-QIDENGDRETDFALWDMADINTGDFQI--VAVY---NGTQKEMNILPGMAIQWPGGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRIS-WDDIQMSH---LEKALRST------------------GSKLTLSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDW-MFKYSLISDIVKGMAFLH-NSVIVSHGNLKSSNCVVDNRFVLKITDYG----LSSIRTESDTEDAHSYYARKLWLAPEL---------------------------------------------SRMECF-----PPGGT-------QKGDVYSFGIILQEVALRRGVFYLE-GDLLSPKEIVDRVAL----GEWPYLRPSLNPQAHSEELG-QLMQRCWAEEPSDRPE----FSHISVLLRKQNREHRSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAV-KTFKI--RHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGEVK 814

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 389.037 bits (998), Expect = 4.874e-116
Identity = 348/1072 (32.46%), Postives = 516/1072 (48.13%), Query Frame = 1

Query:  436 MSVEKKVWAIIGP--QETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIIS-SDDKENE----FILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNY-------FVVSLVLR-----LEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKD---GMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE--ICR--TNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPE-YMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLE 3561
            +  E   WA IGP    T          + + MI+         +  + Y++   T P    L  Y +   + F WN  S++  SD K  E    F L+   + +   NIT +   LV      G  N  +++++       R+ VF+    ++F  L+  + K       Y       F  S   R         SD  F        + ++  I++++EP+ Q  K   +  K    R  FN    D    S   + S   YD ++LY   +     N SL    +   G  + K + NR Y  V G +  ID  G+   ++ +  +     G+ +I       + +G+  E        I W    +P D+P CGF  E   CR  T      I + LF++LI++  V+ F+ +  + EKEL   LW+I    +I  S+   LEK    T                   S+  L+    N G +L  D          Y    +V  +      + +TRKV  ELK +R++   +L +F+GA I+  +  +V E+C RGSLQ++L +  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VD+R+ +K+TD+G    L+ +  + DT + + Y+    W APE+ R                                             +E F     PP          QK D+YSFG+I  E+   +  F        SPKEI+ R+ +     + PY RP L+  + +++    L++ CW E  + RP     ++   VL  ++   V      +  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + K F I      +E+LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMESNGE LKIH S A    +   N F +  RG +E+KGKG + T+WL+G+++
Sbjct:  117 LKFEHNPWAFIGPGCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQ-MEIYTSITNTGPTHKKLGEYALHLYRHFGWNQHSLLMFSDTKMGERACYFALEGLYTEMHEENITTM--DLVFEEN-KGPVN--YSELLHKIQGDGRV-VFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPWARGDSDDVFAK-----EAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRM-FNFTVDD----SLMNIISGGFYDGLMLYCHAL-----NESLSDSHERPSGESVSKRMWNRTYYGVTGLV-QIDENGDRETDFALWDMADINTGDFQI-----VAVYNGTQKEMNILPGMAIQWPGGKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRIS-WDDIQMSH---LEKALRST------------------GSKLTLSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDW-MFKYSLISDIVKGMAFLH-NSVIVSHGNLKSSNCVVDNRFVLKITDYG----LSSIRTESDTEDAHSYYARKLWLAPELSR---------------------------------------------MECF-----PPGGT-------QKGDVYSFGIILQEVALRRGVFYLE-GDLLSPKEIVDRVAL----GEWPYLRPSLNPQAHSEELG-QLMQRCWAEEPSDRPE----FSHISVLLRKQNRSVPHYSIVLSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAV-KTFKI--RHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGEVK 1062

[Close]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2])

HSP 1 Score: 365.54 bits (937), Expect = 1.340e-107
Identity = 279/768 (36.33%), Postives = 409/768 (53.26%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPR-DIPECGFNGEICRTNEKXXXXXXXXXXXXXXX--XXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR    V G ++ ID K   + ++++  +    +G+  I  +G +   +G+  E  +   + I W    P  D P CGF+   C+ +   +   V++   L L+     S  + +  + EKEL  +LW+I R +E+ F +     K                        S+  L++   + G ++    G   L      +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ +LH N  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + +    +Y   L WTAPE+                     LI +R                              PP          QK D+YSFG+I  E+     PF        SPKEII++  V N Q K  +RP     SR  ++   L++ CW E+  +RP    I   F   F ++    + +  +M  Y  NLE  V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LLE++ K F I      N++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMES GEAL+IH S A    +     F +  RG +E+KGKG + T+WL+G+
Sbjct:  380 NRRLWGVTGLVS-IDQKNARFTDFSLWAMTNLKSGQYAI--VGHY---NGTSKEILWSPTEKIQWPKGCPPLDYPPCGFSP--CKEDHLPVLGIVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRI-RWEELQFESPNKYHK---------------------RAGSRLTLSQRGSSYGSLITAH-GKYQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRYSLINDIVKGMNYLH-NSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCENEDSHALYAKKL-WTAPEL---------------------LIYDRH-----------------------------PPQGT-------QKGDVYSFGIILQEIALRNGPFYVE-GMDLSPKEIIQK--VRNGQ-KPYFRPTTDN-SRHCEELTILMEGCWSEDPAERPDFSHI-KVFIAKFNKQHQYSQYLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQV-KTFKI--RHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFELQLRGDVEMKGKGKMRTYWLLGE 1044

[Close]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 356.681 bits (914), Expect = 1.259e-107
Identity = 247/643 (38.41%), Postives = 356/643 (55.37%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKF--SFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGK 3522
            EKEL  +LW+I R +E+ F N E   K   S +T   ++       CLP  ++ Q+  +           P     N++   + N+    KR      I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F +S   D+++G+ FLH +  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D   Y  +    WTAPE+L                                                   ++  PP P +      QK D+YSFG+I  E+      F        SPKEI+++  V N Q +  +RP + +   +++  I L+  CW E    RP     +N+ K    +       ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + + F I      N +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S A    +   + F +  RG IE+K K
Sbjct:   99 EKELASMLWRI-RWEELQFGNSERYHKTAGSRLTLSLVRHPCTLPPCLPLYQNPQYPTSPP----NTPCHPQIPHGNVVAIKHVNK----KR------IELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRNSLINDIVKGMCFLHRS-IIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCEADD-AYALYAKKLWTAPELL---------------------------------------------------RMTRPPAPGT------QKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQK--VRNGQ-RPYFRPTVDISCHSEELGI-LMDRCWAEEPLDRPD----FNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAV-RTFKI--RHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 652

[Close]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 350.517 bits (898), Expect = 6.163e-107
Identity = 246/641 (38.38%), Postives = 351/641 (54.76%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGK 3522
            EKEL  +LW+I R +E+ F N E   K +  +R  +    +    L        + A    N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F +S   D+++G+ FLH +  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D   Y  +    WTAPE+L                                                   ++  PP P +      QK D+YSFG+I  E+      F        SPKEI+++  V N Q +  +RP + +   +++  I L+  CW E    RP     +N+ K    +       ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + + F I      N +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S A    +   + F +  RG IE+K K
Sbjct:    3 EKELASMLWRI-RWEELQFGNSERYHKTAG-SRLTLSLRGSSYGSLMTAHGKYQIFA----NTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRNSLINDIVKGMCFLHRSI-IGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCEADDA-YALYAKKLWTAPELL---------------------------------------------------RMTRPPAPGT------QKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQK--VRNGQ-RPYFRPTVDISCHSEELGI-LMDRCWAEEPLDRPD----FNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAV-RTFKI--RHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547

[Close]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 350.132 bits (897), Expect = 3.905e-106
Identity = 245/641 (38.22%), Postives = 349/641 (54.45%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGK 3522
            EKEL  +LW+I R +E+ F N E   K         +    G++     +   F       N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F +S   D+++G+ FLH +  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D   Y  +    WTAPE+L                                                   ++  PP P +      QK D+YSFG+I  E+      F        SPKEI+++  V N Q +  +RP + +   +++  I L+  CW E    RP     +N+ K    +       ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + + F I      N +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S A    +   + F +  RG IE+K K
Sbjct:   65 EKELASMLWRI-RWEELQFGNSERYHK--------TRGSSYGSLMTAHGKYQIF------ANTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRNSLINDIVKGMCFLHRSI-IGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCEADDA-YALYAKKLWTAPELL---------------------------------------------------RMTRPPAPGT------QKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQK--VRNGQ-RPYFRPTVDISCHSEELGI-LMDRCWAEEPLDRPD----FNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAV-RTFKI--RHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600

[Close]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 349.362 bits (895), Expect = 1.443e-105
Identity = 246/641 (38.38%), Postives = 351/641 (54.76%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGK 3522
            EKEL  +LW+I R +E+ F N E   K +  +R  +    +    L        + A    N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F +S   D+++G+ FLH +  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D   Y  +    WTAPE+L                                                   ++  PP P +      QK D+YSFG+I  E+      F        SPKEI+++  V N Q +  +RP + +   +++  I L+  CW E    RP     +N+ K    +       ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + + F I      N +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S A    +   + F +  RG IE+K K
Sbjct:   88 EKELASMLWRI-RWEELQFGNSERYHKTAG-SRLTLSLRGSSYGSLMTAHGKYQIFA----NTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRNSLINDIVKGMCFLHRSI-IGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCEADDA-YALYAKKLWTAPELL---------------------------------------------------RMTRPPAPGT------QKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQK--VRNGQ-RPYFRPTVDISCHSEELGI-LMDRCWAEEPLDRPD----FNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAV-RTFKI--RHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632

[Close]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 350.517 bits (898), Expect = 3.212e-105
Identity = 247/643 (38.41%), Postives = 353/643 (54.90%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKF--SFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGK 3522
            EKEL  +LW+I R +E+ F N E   K   S +T   ++    G++     +   F       N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F +S   D+++G+ FLH +  I  HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D   Y  +    WTAPE+L                                                   ++  PP P +      QK D+YSFG+I  E+      F        SPKEI+++  V N Q +  +RP + +   +++  I L+  CW E    RP     +N+ K    +       ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A MSL LLE + + F I      N +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S A    +   + F +  RG IE+K K
Sbjct:  133 EKELASMLWRI-RWEELQFGNSERYHKTAGSRLTLS-LRGSSYGSLMTAHGKYQIF------ANTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRNSLINDIVKGMCFLHRS-IIGSHGNLKSSNCVVDSRFVLKITDYGLASFRS--SCEADD-AYALYAKKLWTAPELL---------------------------------------------------RMTRPPAPGT------QKGDVYSFGIILQEIALRNGCFYIQ-GMDLSPKEIVQK--VRNGQ-RPYFRPTVDISCHSEELGI-LMDRCWAEEPLDRPD----FNQIKAYICKFNKEGSTSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAV-RTFKI--RHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677

[Close]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371])

HSP 1 Score: 382.104 bits (980), Expect = 1.951e-113
Identity = 278/775 (35.87%), Postives = 411/775 (53.03%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDP-IGLFKLD---DGSVLEFEFKNNKNINW-VHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX----KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR ++ V GY+  ID  G+   ++++            +DP  G F++    +G+  E    +   + W +   P DIP+CGF+ E    N+   S    L ++  L +     V     +  + EKEL   LW++ R +++  S+ E             + + +          S+  L+    N G +L  + G   +      YK   V VKRV     I +TRKV  ELK +R++   +L +F+GA  +  +  ++ E+C RGSLQD+L +  +T ++ +F  S   D+++G++FLH N  I  HG+LKSSNC+VD R+ +K+TD+G+  F     P+P+   +  F    WTAPE+L                                                   ++  PP   S      Q  D+YSFG+I  E+      F        SPKEII R +   +Q   P+RP + L S  ++    L++ CW E+  +RP  + I    +    E   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +  + HARE+A M+L LL+ + + F I       E+L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S      +   + F +  RG +E+KGKG V T+WL+G+
Sbjct:  382 NRSFQGVTGYLK-IDRNGDRDTDFSL----------WDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRV-RWEDLQPSSLE-------------RHLRSAG--------SRLTLSGRGSNYGSLLTTE-GQFQVFAKTAYYKGNLVAVKRVNRK-RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDW-MFRYSLTNDIVKGMLFLH-NGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQ-GHTLFAKKLWTAPELL---------------------------------------------------RMASPPARGS------QAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIER-VTRGEQ--PPFRPSMDLQSHLEELG-QLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAV-RSFRI--RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2f (guanylate cyclase 2f [Source:MGI Symbol;Acc:MGI:105119])

HSP 1 Score: 307.375 bits (786), Expect = 1.162e-86
Identity = 214/556 (38.49%), Postives = 299/556 (53.78%), Query Frame = 1

Query: 1909 SITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSP-KEIIRRLIVLNDQFKVP---YRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVL-FGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVE-RGVIEVKGKGSVNTFWLIGK 3555
            SI        + ++++ + N+N  +G   +     +V EFC R SL+D+L +  +  ++ +F SS   D+I+G+ +LH    I  HG LKS NC+VD R+ +K+TD+G  + L  +     + E      L WTAPE+LR               ++LG                  +F+ D                            +YSF +I  E+     PF       + P KEII RL       K+P   YRP +S       + + L+K CW E + QRPT   I+N+FK    G+K N+++ M   +  Y+ NLE  + +RTEEL  EK++ E+LL QMLP+ VAE L++   VE E FD V++YFSDIVGFT ++    P EV++LLN LYT FD II + +VYKVETIGD+YMV SGLP +    HA E+ANMSL +L  +               +++RIGLHSGP  AGVVG   PRYCLFGDTVN ASRMES G   +IH S + +  +  L+E + VE RG  E+KGKG+  TFWL+GK
Sbjct:  586 SIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVKLDW-MFKSSLLLDLIKGMKYLHHREFI--HGRLKSRNCVVDGRFVLKVTDYGFNDILEMLR---LSEEEPSEEELLWTAPELLRAP-----------GGIRLG------------------SFAGD----------------------------VYSFAIIMQEVMVRGAPF----CMMDLPAKEIIDRL-------KMPPPVYRPVVS-PEYAPAECLQLMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVG---TFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGRTELKGKGTEETFWLVGK 1063

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 285.419 bits (729), Expect = 5.318e-83
Identity = 169/355 (47.61%), Postives = 236/355 (66.48%), Query Frame = 1

Query: 2503 NSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRP---TAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            N L +   QK+D+YSF +I  E+     PF        SPKEI+++  V N Q +  +RP +   ++ +++ + L++ CW ++ T+RP     K    RF    G   ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HA E+A M+L LL+ ++  F I      +++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNG+ALKIH S      +  L  F +  RG +E+KGKG + T+WL+G+
Sbjct:  261 NPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQK--VRNGQ-RPYFRPSIDR-TQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGG--TSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSS-FRI--RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 605

HSP 2 Score: 115.161 bits (287), Expect = 1.060e-25
Identity = 81/242 (33.47%), Postives = 125/242 (51.65%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKS------CCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEIL 2325
            EKEL  +LW+I R +E+ F N +   K +              + L     S   L  +        N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ FLH N  I  HG LKSSNC+VDSR+ +K+TD+G+  F +  + +PD    +Y   L WTAPE+L
Sbjct:   50 EKELASMLWRI-RWEELQFGNSDRYHKGA-----------GSRLTLSLRGSSYGSLMTAHGKYQIFANTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDW-MFRYSLINDLVKGMAFLH-NSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRS--TAEPDDSHALYAKKL-WTAPELL 258

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 285.804 bits (730), Expect = 1.090e-79
Identity = 169/355 (47.61%), Postives = 236/355 (66.48%), Query Frame = 1

Query: 2503 NSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRP---TAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            N L +   QK+D+YSF +I  E+     PF        SPKEI+++  V N Q +  +RP +   ++ +++ + L++ CW ++ T+RP     K    RF    G   ++++ +  +M  Y  NLEK V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HA E+A M+L LL+ ++  F I      +++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNG+ALKIH S      +  L  F +  RG +E+KGKG + T+WL+G+
Sbjct:  695 NPLPTTGMQKADVYSFAIILQEIALRSGPFYLE-GLDLSPKEIVQK--VRNGQ-RPYFRPSIDR-TQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGG--TSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSS-FRI--RHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGE 1039

HSP 2 Score: 114.775 bits (286), Expect = 3.473e-25
Identity = 81/242 (33.47%), Postives = 125/242 (51.65%), Query Frame = 1

Query: 1618 EKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKS------CCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEIL 2325
            EKEL  +LW+I R +E+ F N +   K +              + L     S   L  +        N GH               +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ FLH N  I  HG LKSSNC+VDSR+ +K+TD+G+  F +  + +PD    +Y   L WTAPE+L
Sbjct:  484 EKELASMLWRI-RWEELQFGNSDRYHKGA-----------GSRLTLSLRGSSYGSLMTAHGKYQIFANTGH---------------FKGNVVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDW-MFRYSLINDLVKGMAFLH-NSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRS--TAEPDDSHALYAKKL-WTAPELL 692

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025])

HSP 1 Score: 251.136 bits (640), Expect = 6.282e-68
Identity = 160/350 (45.71%), Postives = 213/350 (60.86%), Query Frame = 1

Query: 2530 KSDIYSFGMIFYEL--HSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKK-----NLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            + D+YSF ++  +L       PF      + +P+EII R  + + +  VP RP L L  + D + + L++ CW E+   RP    I+   K    E       ++++ M  K+  Y  +LE+ V +RT EL  EK++ E+LL  MLP  V EQL   K VE E F+SV+I+FSDIVGFT+L    SP +V+ LLN LY+ FD  I + +VYKVETIGD+YMV SGLP +   +HA E+A M+L LL  +T  F I       ERLKLRIGLH+GP  AGVVG   PRYCLFGDTVNMASRMES+   L+IH S++    +L    +H+ +RG I VKGKG   TFWL GK
Sbjct:  743 QGDVYSFAILLRDLIHQQAHGPF---EDLEAAPEEIISR--IKDPRAPVPLRPSL-LEDKGDGRIVALVRECWDESPELRP----IFPSIKKTLREASPRGHVSILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLS-VTTHFQI--GHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGK 1079

HSP 2 Score: 118.627 bits (296), Expect = 2.721e-26
Identity = 154/643 (23.95%), Postives = 274/643 (42.61%), Query Frame = 1

Query:  460 AIIGPQETCRTEADI----AMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSII--SSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVDSRSLR---NFVIISHIEPEGQLIKTESSKFKYFMS----RPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVH-DIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKI-----DRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRK-VKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            A+ GP   C   A++    A  +NI +   F       +D     T V   P    ++  L   L+   W  + +   SS D   E + +   +V         H  +  S     S+++   + + N     R+ + I S  +   +L A  + GL DTG  FV  L+ +LE   DS +  +    + +R    +  +  I P           F+  +S    RPPF  +S   S    +P  S+YL+DA+LLYA  V  + K          ++          + + G +  +D++G+ + +Y+V  L  + N  + +        D    +   ++N+ N +W H  +P   P CGF+ ++C+T    ++        +I  +        +      L RL  K+     D   +I + +  LL +     R     +   NV      D+  + A + C        D       + +Y+  +V +  +       + +  V++E+  + E+ + N+  F G   E  +  +V ++C +GSLQDV+ ++    ++ +F  SFA+D++ GL+FLH +P +  HG+LK SNCLVDS   +KL+ FG+ EF    + +    E      L+WTAPE+LR
Sbjct:  117 ALFGP--ACPEAAEVIGLLASEWNIPLFD-FVGQMAALKDHFWCDTCVTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDGLQ---FHFNITASMRYNSSSSDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGL-DTGE-FVFILLQQLE---DSFWKEVLTKDKVIRFPKVYESVFLIAPSAYGGGIGDDGFRKQVSQELRRPPF--QSSITSEDQVSPY-SAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVL-LDSQGKRHVDYSVYALQESGNRSLFLP---FLHYDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTVTVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRG--TPVSRRNV-----SDTSTVKASADCGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDW-IFKLSFAYDIVNGLLFLHGSP-LRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLR 732

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q7JQ32|GC76C_DROME (Receptor-type guanylate cyclase Gyc76C OS=Drosophila melanogaster OX=7227 GN=Gyc76C PE=1 SV=1)

HSP 1 Score: 461.455 bits (1186), Expect = 5.980e-138
Identity = 372/1185 (31.39%), Postives = 597/1185 (50.38%), Query Frame = 1

Query:  193 NQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEFILQNCLSVLK----AHNITILH------NKLVMSPAIYGSANNKF-NKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVD--------------SRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQD---KSNTS-YAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXX---------XNRYYKSVFGYMNHIDNKGEAYGNYTV---------NQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVH--DIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXX---XXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLS-NYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQ---IDLIKLCWQENATQRPTAKVIYNRFKVLFGEK-KNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVE-RGVIEVKGKGSVNTFWLIGKLEQNI 3570
            ++T++ +GY+  T    D++ R     G  ISGALT A++++N         +LLP+ Y + + + +T G+   + +A+ +M +   +  I GP+  C  EA ++ + NI MIS+ C +      +    TF RT P  + +   L++ L+ + WN  SI+  D      +      +LK      N+TI H      N++     +     + +  ++V+NT   TRIYVF+G+   +   + ++   GL   G Y V+ + + + +  ++     +VD              ++  R+ ++++   P    I+  + + + + S+PPFN+E      +SN S +  + ++YLYD+V LYA  V  +L+  +     D +                NR Y S+ G    ID  G++ GN++V         N   +  N  M   P+  F   +    E++  N  +I+W    + P D P CGF  E+C+ ++   +  V+  +L +L      ++  + +  + E E+E LLWKID  +   +S +E++   S ++                      + A+S    G      + TS   L   +   V +K + F     I+R++ KE++ LRE+ + N+N F+GA +E     +V ++C +GSL D++ +  + K   +F++S   D+I+G+I++H N  + +HG+LKSSNC+V SRW +++TDFG+ E L   +      E+ ++ +  W APE+LR+ I    H +Q                   K DV A                                     F +I YE+ S + PF   N+     PKEI+  +  L  + + P+RP++  +   +      +  I+ CW E+  +RP   VI NR K + G K KN+++ M E M  Y  NLE  V +RT  L EEK + E+LL++MLP  VAE+L   + VE  ++D V+IYFSDIVGFT ++   +P +V+N LN LYT FD+II  ++VYKVETIGD+YMVVSGLP +  D HA E+A+M+L LL  + +  +       NE LKLRIG+H+GP  AGVVG   PRYCLFGDTVN ASRMESNGEALKIH S    L +  L   +I E RG++ +KGKG V T+WL G  E  I
Sbjct:   22 HRTVLTVGYL--TALTGDLKTR----QGLAISGALTMALDEVNK------DPNLLPNVY-LDLRWNDTKGDTVLATKAITEM-ICDGIATIFGPEGPCYVEAIVSQSRNIPMISYKCAE----YRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYED------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQF-TKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMV--PVAYFHQGEEHP-EYKLING-SIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVS---------------------LMSAQS---YGSRWTNQFVTSTGRL---RGAVVRIKELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDI-KLDDLFIASLIHDLIKGMIYIH-NSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHE-LRQCAENESIGEHQHYRNQLWRAPELLRNHI----HGSQ-------------------KGDVYA-------------------------------------FAIIMYEIFSRKGPFGQINF----EPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRI---AHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q19187|GCY12_CAEEL (Receptor-type guanylate cyclase gcy-12 OS=Caenorhabditis elegans OX=6239 GN=gcy-12 PE=1 SV=3)

HSP 1 Score: 437.187 bits (1123), Expect = 2.098e-128
Identity = 357/1175 (30.38%), Postives = 580/1175 (49.36%), Query Frame = 1

Query:  283 ISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDK---ENEFI-----LQNCLSVLKAHNITILH-NKLVMSPAIYGSANN--KFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLT---------DTG-----------NYFVVSLVLRLEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPP-----FNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILK----NPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQL-----IINANG------EMKIDPIGLF--KLDDGSVLEFEFKNNKNINWVH-DIPRDIPECGFNGEICRTNE----KXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDW------GTSNLILCMYKNQEVVVKRV-YFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF---LTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPF-----LSNYSSQNSPKEI---IRRLI--VLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE--KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPT--QFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNE-FHIVERGVIEVKGKGSVNTFWLIGK 3555
            +SGAL  A+ +IN        + L+P+ YQ+   F  T G  ++S +   +   +      IGP++ C+TEA +A + N+ +IS+ C D  ++ D   Y TF RT P    +    +S +K++ W   S++    K   +NE       +    +  + H   I++ +KL  S     S  +       +++T Q+TRIY+   +      +L  + E GLT         DT            N+F+ + +  L    D+   N   D + L        I P    +K  S +F  F  +       F V+  D    +     + YLYDAV LYA  +  +++    + S     DG  +   ++N+ Y+S+ G+   ID +G + GN+++        I+N +       +  +D   +F    D   +   +FK+++ I W+  + P D P CGF+GE CR         + + + + +  +++   +   I+S+R+EKEL  ++WKID                 +  R  +  + N        E +  L+            P W      GT    L  YK   V +K + Y      +TR+ KKEL+ +R++++ N+N F+G I+      VV E+C +GSL D+L +  L  ++ ++++SF  D+++G++++H++ ++  HG+LKS+NCL+ SRWT+++ DFG+RE    + Y S       Y  + +  WTAPE +                                  +N S            + I  PP P         K+D YSFG+IF+E+ + + P+       + + + +PK+     R L+   +   +  PY RP  S L   +  + +++  CW  +  QRP  K I N+ K LF +  K+N+++ M   M  Y   LE  V +RT EL++E+++++ LL +MLP  VAEQL   + V  EAF  V+IYFSDIVGFT ++G  +P EV+  LN+LYT FD II  ++VYKVETIGD+YMVVSG+P     + HA ++A M++ +L  + + F IP      E L +RIG+H+GPC AGVVG   PRY LFGDTVN ASRMESNGEAL+IHCS +    +  +++ F + ERG + +KGKG + T+WL G+
Sbjct:  141 VSGALVAAIVEINQ------DKDLIPA-YQLKYVFGNTCGNDSHSTRLFME-HWQAGARVFIGPEKNCKTEAAMAASQNLPIISYRCNDQDISRDDYHYRTFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYDVKKGQVKNELFETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQSIENAIKSTMQTTRIYLTFDNVRLFRTMLSIMGEMGLTQQDYMLIYVDTNYDWLNVYHSMNNHFLRNTMTYLHHSWDA---NNSSDRKMLDYARSALSIIPTP--VKLNSQRFYNFWKKAGDYMHHFGVQKADNLKGNRI---ACYLYDAVYLYAKAIHELVEEYGNDDSYDPTADGKAIIDRIVNKKYRSIQGFDMRIDERGNSKGNFSLLSWQKVAPIMNKSDPSYYPLDHALDLTAIFVEAPDKDRLPNLQFKSSR-IQWLKGEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSLVLTGFTLNYIRSRRFEKELS-MIWKID----------------PYEVRRVVGGVNN--------ESTASLMQSDVMQFAKTKTPWWSKAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYSVTVVREYCSKGSLHDILRNENLKLDH-MYVASFVDDLVKGMVYIHDS-ELKMHGNLKSTNCLITSRWTLQIADFGLRELREGIMYDS------SYNIWENFLWTAPEAM---------------------------------TINGS------------LAISNPPTP---------KADAYSFGIIFHEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDTSDLEVQNYVK-EVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELKDEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKLYTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAV-RSFSIPHRSC--EPLMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLLEERGSLAIKGKGQMTTYWLNGR 1207

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1)

HSP 1 Score: 386.341 bits (991), Expect = 3.340e-114
Identity = 280/775 (36.13%), Postives = 416/775 (53.68%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPI-GLFKLD---DGSVLEFEFKNNKNINW-VHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX----KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR ++ V GY+  ID+ G+   ++++            +DP  G F++    +G+  E    + + +NW +   P DIP+CGF+ E    N+  +S    L ++  L +     V     +  + EKEL   LW++ R ++++ S+ E             + + +          S+  L+    N G +L  + G   +      YK   V VKRV     I +TRKV  ELK +R++   +L +F+GA  +  +  ++ E+C RGSLQD+L +  +T ++ +F  S   D+++G++FLH N  IC HG+LKSSNC+VD R+ +K+TD+G+  F       P+    +Y   L WTAPE+L                                                   ++  PP   S      Q  D+YSFG+I  E+ + +           SPKEII R +   +Q   P+RP L+L S  ++  + L++ CW E+  +RP  + I    +    E   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +    HA E+A M+L LL+ + + F I       E+L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH S      +     F +  RG +E+KGKG V T+WL+G+
Sbjct:  386 NRSFQGVTGYLK-IDSSGDRETDFSL----------WDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRV-RWEDVEPSSLE-------------RHLRSAG--------SRLTLSGRGSNYGSLLTTE-GQFQVFAKTAYYKGNLVAVKRVNRK-RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDW-MFRYSLTNDIVKGMLFLH-NGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDL---DPEQGHTVYAKKL-WTAPELL---------------------------------------------------RMASPPVRGS------QAGDVYSFGIILQEI-ALRSGVFHVEGLDLSPKEIIER-VTRGEQ--PPFRPSLALQSHLEELGL-LMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAV-RSFRI--RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1)

HSP 1 Score: 386.341 bits (991), Expect = 3.854e-114
Identity = 279/775 (36.00%), Postives = 412/775 (53.16%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDP-IGLFKLD---DGSVLEFEFKNNKNINW-VHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX----KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR ++ V GY+  ID  G+   ++++            +DP  G F++    +G+  E    +   + W +   P D+P+CGF+ E    N+   S    L ++  L +     V     +  + EKEL   LW++ R +++  S+ E             + + +          S+  L+    N G +L  + G   +      YK   V VKRV     I +TRKV  ELK +R++   +L +F+GA  +  +  ++ E+C RGSLQD+L +  +T ++ +F  S   D+++G++FLH N  IC HG+LKSSNC+VD R+ +K+TD+G+  F     P+P+   +  F    WTAPE+L                                                   ++  PP   S      Q  D+YSFG+I  E+      F        SPKEII R +   +Q   P+RP + L S  ++    L++ CW E+  +RP  + I    +    E   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +  + HARE+A M+L LL+ + + F I       E+L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH S      +   + F +  RG +E+KGKG V T+WL+G+
Sbjct:  382 NRSFQGVTGYLK-IDRNGDRDTDFSL----------WDMDPETGAFRVVLNYNGTSQELMAVSEHKLYWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLISFLIVSFFIYRKMQLEKELVSELWRV-RWEDLQPSSLE-------------RHLRSAG--------SRLTLSGRGSNYGSLLTTE-GQFQVFAKTAYYKGNLVAVKRVNRK-RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDW-MFRYSLTNDIVKGMLFLH-NGAICSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQ-GHTLFAKKLWTAPELL---------------------------------------------------RMASPPARGS------QAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIER-VTRGEQ--PPFRPSMDLQSHLEELG-QLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAV-RSFRI--RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2)

HSP 1 Score: 382.104 bits (980), Expect = 1.365e-112
Identity = 278/775 (35.87%), Postives = 411/775 (53.03%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDP-IGLFKLD---DGSVLEFEFKNNKNINW-VHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX----KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NR ++ V GY+  ID  G+   ++++            +DP  G F++    +G+  E    +   + W +   P DIP+CGF+ E    N+   S    L ++  L +     V     +  + EKEL   LW++ R +++  S+ E             + + +          S+  L+    N G +L  + G   +      YK   V VKRV     I +TRKV  ELK +R++   +L +F+GA  +  +  ++ E+C RGSLQD+L +  +T ++ +F  S   D+++G++FLH N  I  HG+LKSSNC+VD R+ +K+TD+G+  F     P+P+   +  F    WTAPE+L                                                   ++  PP   S      Q  D+YSFG+I  E+      F        SPKEII R +   +Q   P+RP + L S  ++    L++ CW E+  +RP  + I    +    E   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +  + HARE+A M+L LL+ + + F I       E+L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEAL+IH S      +   + F +  RG +E+KGKG V T+WL+G+
Sbjct:  382 NRSFQGVTGYLK-IDRNGDRDTDFSL----------WDMDPETGAFRVVLNFNGTSQELMAVSEHRLYWPLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRV-RWEDLQPSSLE-------------RHLRSAG--------SRLTLSGRGSNYGSLLTTE-GQFQVFAKTAYYKGNLVAVKRVNRK-RIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDW-MFRYSLTNDIVKGMLFLH-NGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQ-GHTLFAKKLWTAPELL---------------------------------------------------RMASPPARGS------QAGDVYSFGIILQEIALRSGVFYVE-GLDLSPKEIIER-VTRGEQ--PPFRPSMDLQSHLEELG-QLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAV-RSFRI--RHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGE 1050

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BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A210QCM1 (Guanylate cyclase OS=Mizuhopecten yessoensis OX=6573 GN=KP79_PYT05201 PE=3 SV=1)

HSP 1 Score: 634.795 bits (1636), Expect = 0.000e+0
Identity = 427/1150 (37.13%), Postives = 636/1150 (55.30%), Query Frame = 1

Query:  193 NQTIIIIGYVAGTEYPPDIEIRN-YKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL------EAISDSAF-GNIQVDS-RSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNT-SYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTV---NQLIINANGEMKIDPIGLFKLDD--GSVLEFEFKNNKNINWVHD-IPRDIPECGFNGEICRTNEKXXXXXX--XXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHIL-QPDWGTSNLI--------LCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFD-EHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            ++ +I +GY+ G+E      I   Y R G+ ISGA+T AV ++N          +LP+ + +     ETYG    SI+   ++ + K +WA IGPQETC  E  +A AFN+ MIS++C+++ ++  +  Y TF  TRP  S ++  +VS L+   W  V+ + S + E     +   ++L  H+I +   K    P  +    N F +IV  TF  TRIYV +G  ++  GL+  LY++GL +TG+Y+VV ++L        + I    F  N+ + S ++ R F+ +    P  Q     S K  +++  PPFN  +  K+ T    P E+++LYDAV LYA  V  +L   + G PKDG L+   L  + YKS  GY N I++ G+A GN+++      +++      + PIG+F+L++    + EF   + ++ +W +  +P D P CGF  E C   + + +  +      +L++V+ +S  + ++ RYE++L  LLWKID  K+I   N                          F      LL+ +   +G    Q   G+ N I        +  Y+   +   R+     + +TR V+KELK +RE+ + N+N F+GA I+     +V  +C RGSLQD+L +  L  +  +F++S  FD++RG+I+LH   +I +HG L+SSNC+VDSRW VK+TDFG+ EF+     + +  EY Y+ +L W APEILR         N+F           R+ S     DV                                     YSF +I YE+HS + P+    ++  SPKEII+R  V +     P+RP+L+ L  T K   D+IK CW E+  +RP  K I  + K L  G K N+ + M   M  Y  NLE  V +RT++L EEKK+ EELL QMLP  VAEQL++ K+VEAE+FDSV+IYFSDI GFT ++   +P +V+NLLN LYT FD I++N++VYKVETIGD+YMVVSGLPT+    HA E+A+MSL+LL+ I K F I     ++  ++LR+G+HSG C AGVVG + PRYCLFGDTVN ASRMES GEALKIHCS    + +  L  +H+ ERG++ +KGKG V T+WL+G+
Sbjct:   25 SKEVIKLGYITGSE---RYNINQFYHRPGQSISGAITLAVKEVNE------DPHILPN-HTLEFVIAETYGMELISIKQTVEL-LSKDIWAYIGPQETCIHEGRVAAAFNLPMISYYCSESEVSAKTL-YPTFCSTRPTASHVSRSVVSILRHLNWRKVTFVHSSEPEFVHTAKTISNLLPQHDIEVTFMKEYKGPYFHLHTENPFVRIVSETFVDTRIYVMLGQFYDFIGLMDHLYDRGLLETGDYYVVGVILGQYDQNDPQRIIKGIFSSNVSLSSVKAFRYFMGVLQSPPVHQEYMEFSEKVNHYLELPPFNYVNPLKNFTLKIIPPEAAFLYDAVWLYARAVHEVLS--ARGDPKDGALVASKLKFKTYKSAMGYENRINSNGDAMGNFSLIARKSGLVDNQTVWHLSPIGVFQLNENFSELPEFRLYDAESFDWPYGKVPVDEPACGFRREKCIRPKSYTTEILFGVAGGILLIVVIISVLIYRNWRYEQDLASLLWKID-YKDISMRNQ-------------------------FGGTMNHLLSTNRRTMGRATSQISLGSQNEIDYRQLFTKVGTYRGT-IAAIRIVNKKNVELTRNVRKELKLMRELRHDNINPFIGACIDSPHILIVSAYCPRGSLQDILENDDLQLD-SMFIASLVFDIVRGMIYLH-GSEIRYHGKLRSSNCVVDSRWVVKITDFGLNEFMA--GAEENFEEYAYYRNLLWLAPEILR--------RNKF-----------RRISGTQAGDV-------------------------------------YSFAVILYEIHSRRGPY---GNTTLSPKEIIKR--VASTTIDPPFRPRLAELDTTPKFVTDVIKECWDEDTIKRPDFKAIRTKLKPLQKGMKPNIFDNMIAIMEKYASNLEAVVEERTDQLIEEKKKTEELLQQMLPRYVAEQLKRGKEVEAESFDSVTIYFSDICGFTAMSSESTPMQVVNLLNDLYTLFDSIVENYDVYKVETIGDAYMVVSGLPTRNGINHAGEIASMSLQLLDSIKK-FKI--RHRQDATIRLRVGIHSGSCVAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHCSNTTRMLLEDLGGYHMTERGMVAMKGKGDVLTYWLLGE 1065

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A139WC82 (Guanylate cyclase OS=Tribolium castaneum OX=7070 GN=TcasGA2_TC011636 PE=3 SV=1)

HSP 1 Score: 610.912 bits (1574), Expect = 0.000e+0
Identity = 421/1137 (37.03%), Postives = 618/1137 (54.35%), Query Frame = 1

Query:  211 IGYVAGTEY-PPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL---EAISDSAFGNIQ-----VDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQD--KSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYT-VNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPR-DIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYV-SPQPDTP----EYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFD-EHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            IGY+ G++  P D+E   Y R G  ISGA++ AV+++N       K  +    +++     ETYGE   S+Q  A +   K V A +GPQETC  EA +A AFN+ MIS+FCT +  T D  ++ TF RTRP  + ++  + S L  F W  V ++     + EF  I    L  L +  IT++  K   +P  +G   N F K+VE T++ TRI+V +G  +E  GL++A+ EK L D G YFV+ + +     E  S    G ++     V  ++ RN++ +    P G   +  +     +M +PPFN  +       +     E++YLYDAV LYA  +  +L     G+P++G  +   +   +YKS  GY+ ++D  G+A GNYT + +     + +  + P+G+F L               I+WV   P    P CGF GE C T+            + ++++ +S  + ++ +YE+EL+ LLWK+D  K+I  +     E  + ITR     I    V L    D+ F  +     IG               +YK +   +K+V+   +I ITR++KKELK +R++ + NLN F+GA  +  +  +V E+C RGSL+D+L +  +  +  +F++S   D++RG+I+LH++P + FHG L S+NCLVDSRW VKL DFG+REF      P    P    E  Y   L + APE+LR            LQ                                E+F+             +  QK DIYSFG+I YELHS   PF    +++ S  EI+ ++I  ++    P+RP L  L  +     D +K CW EN   RP  K I  + + L  G + N+ + M   M  Y  NLE  V +RT++L+EEKK+ E LLY+MLP PVAEQL++  +VEAE+FD V+IYFSDIVGFT ++   +P +V++ LN LYT FD II++++VYKVETIGD+YMVVSGLP + D +HA E+A+MSL LL E+ K F I       E+L LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES G  LKIHCS      +  L  ++++ERG++ +KGKG   T+WL+G+
Sbjct:   13 IGYLTGSQRRPGDLE---YPRPGLTISGAISLAVDEVN-------KGIVGQRGHRLDFIVAETYGEEVISVQKTADLWT-KNVSAYVGPQETCEHEAFMAAAFNLPMISYFCT-HYATSDKTKFPTFARTRPPDTQISKSVASVLVAFNWTHVVLLYLKSPDFEFGNIATIVLQTLASAGITVITTKYWDTPYHHGYGENPFYKLVEQTYRDTRIFVILGHYYEHLGLMVAMEEKKLFDKGEYFVLGVDIEQYDNENPSKYLRGLLRDETDPVAQKAFRNYLGVVPSSPVG--FENFTILVNSYMEKPPFNFPNPLIFVGGSKRIRAEAAYLYDAVHLYAKALIQVLDEG--GNPRNGTDIIDHMKETHYKSAMGYIVYMDENGDAEGNYTLIARKTSTGDEKFGLFPVGIFALKRTDSKLPILHLTDTIDWVGGQPPIAAPICGFRGEKCITH-TMEITSGVTGGIFLVILVISLVLYRNWKYEQELDSLLWKVD-FKDIQINE----EAGTKITRSVHPLIRTSQVSLSSNPDADFRYSTIFTQIG---------------IYKGRVFAIKKVH-KKSIDITREMKKELKMMRDLRHDNLNAFIGACTDPPNICIVTEYCTRGSLKDILENDDVKLDN-MFIASLVGDILRGMIYLHDSP-VRFHGALHSANCLVDSRWVVKLADFGLREFKKGAEEPGVKDPAKVREKCY--RLLYKAPELLR------------LQ--------------------------------ESFVS----------GQLGTQKGDIYSFGIILYELHSRHGPF---GTTELSYPEILSKII--HNTGPQPFRPPLEALENSFDFVRDCLKECWAENPEDRPDFKSIRAKLRPLRKGMRPNIFDNMMAMMEKYANNLEVLVDERTDQLQEEKKKTEALLYEMLPRPVAEQLKRGNKVEAESFDCVTIYFSDIVGFTAMSAESTPLQVVDFLNDLYTCFDSIIEHYDVYKVETIGDAYMVVSGLPIRNDNQHAAEIASMSLHLLAEV-KQFTI--RHRPTEKLMLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGSPLKIHCSSECKDLLHKLGGYNLMERGMVSMKGKGEQQTYWLLGE 1045

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A2S2QRQ8 (Guanylate cyclase OS=Sipha flava OX=143950 GN=Gyc32E_0 PE=3 SV=1)

HSP 1 Score: 608.216 bits (1567), Expect = 0.000e+0
Identity = 420/1163 (36.11%), Postives = 621/1163 (53.40%), Query Frame = 1

Query:  172 LNIKRDRNQTIIIIGYVAGTEY-PPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSL-VLRLEAISDSAF-----GNIQ--VDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQ--DKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTV--NQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDI-PECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFL-----------------SLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            L +  D      ++GY+ G+   P DI    Y + GR ISGA++ AV +IN+    +   SL   ++ +S    ETYGE + SI   A++  +K + A IGPQETC  EA +A AFN+ MIS++C D+  T D   + TF RTRP  + ++  + + LK F W  V+ + S+  +  F  I      V     I I   K   S  ++G   N F K+V +T+Q TRIYV +G+ ++  GL++A+ E  L   G YFVV + V + +A +   +      N Q  +  ++ R+F  +    P G   K  S K   +M +PPF   +            +E++YLYDAV LYA  V  +++      P++G  +   L   +Y+S  GY  ++D  G+A GNYT+   Q +++A+    + P G F          E     N+ W+   P    P CG+ G+ C T+     + +    LL+++  +S    ++ +YE+EL+ LLWK+D  K+I+ ++ E     S I+R     I    V L    D+ F  +     +G               +YK +   +K V    +I ITR +KKELK +R++ + NLN F+GA  +  +  +V E+C+RGSL+D+L +  +  +  +F++S   D+IRG+++LH++P + +HG+LKSSNCLVDSRW +KLTDFG++EF       P      +FL                  L + +PE+LR                                            C  + I+I F            QK D+YSF +I YELHS + PF  N+    S  +I+R++I        P+RP L LL        D ++ CW EN   RP  K I  + + +  G + N+ + M   M  Y  NLE  V +RT++L EEKK+ + LLY+MLP  VAEQL++  +V+AE FD V+IYFSDIVGFT ++   +PF+V++ LN LYT FD II+N++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LLE + K F I    Y  + L+LRIG+HSGP CAGVVG + PRYCLFGDTVN  SRMES G+ALKIHCS+     +  L  +   ERG++E+KGKG+V T+WL+G+
Sbjct:   10 LQLAVDGQTDEFVLGYLTGSRRRPGDI---TYSKPGRMISGAISLAVEEINAGLFKDKGHSL---SFLVS----ETYGEESTSILETAEL-WKKNISAFIGPQETCFHEARMAAAFNLPMISYYCMDSD-TSDKVLFPTFARTRPPDTQISKSVAAVLKAFNWTQVTFLYSNADDTHFGKIASTITEVFSKSGIEITAKKTWNSHYLHGYTTNPFVKLVTDTYQDTRIYVVLGNYYDHTGLVIAMDEMDLFKNGEYFVVGVDVEQYDAENPRKYLTGMLSNKQDPILEKAFRSFFSVVPTPPRG--FKNFSVKVNEYMEKPPFLFPNPLVQLGGVKQISVEAAYLYDAVHLYARSVLELIECGD--DPRNGTAMMAKLKGSHYRSAMGYEVYMDENGDAEGNYTLVSRQRLLDASKGYGLFPAGRFTKLRNLTRNPELTLVTNVEWISGKPPVAEPACGYRGQKCITH-TAEILSIVAGTLLLVLAVISLVFYRNWKYEQELDSLLWKVD-YKDIEINDTENGSTSSKISRALHPLIRTSQVSLSSNPDADFRYSSIFTTVG---------------IYKGRVFAIKNVK-KKSIDITRAMKKELKVMRDLRHENLNGFIGACTDPPNICIVTEYCNRGSLKDILENEDVKLDN-MFVASLVADIIRGMLYLHDSP-LRYHGNLKSSNCLVDSRWVLKLTDFGLQEFKKDCEDFPH-----HFLQHDFRLQKDDEVDCKCEGLLYISPELLR--------------------------------------------CYNSSIQISF----------GTQKGDVYSFSIILYELHSRKGPFGENHGLGVS--DILRKIIYCPQDGSNPFRPPLDLLENNFDFVRDCLEDCWAENPDDRPDFKTIRAKLRPMRKGMRPNIFDNMMAMMEKYANNLEVLVDERTDQLVEEKKKTDALLYEMLPKYVAEQLKRGHKVQAENFDCVTIYFSDIVGFTSMSAESTPFQVVDFLNDLYTCFDSIIENYDVYKVETIGDAYMVVSGLPIKNGDMHAAEIATMSLHLLEAVKK-FQIRHRPY--DTLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTTSRMESTGQALKIHCSQECRTLLERLGGYQTTERGLVEMKGKGNVRTYWLVGE 1072

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A2H8TID5 (Guanylate cyclase OS=Melanaphis sacchari OX=742174 GN=Gyc32E_0 PE=3 SV=1)

HSP 1 Score: 604.749 bits (1558), Expect = 0.000e+0
Identity = 416/1151 (36.14%), Postives = 611/1151 (53.08%), Query Frame = 1

Query:  208 IIGYVAGTEY-PPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEF--ILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSL-VLRLEAISDSAFGNIQVDSR-------SLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQ--DKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTV--NQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDI-PECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFL-----------------SLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            ++GY+ G+   P DI    Y + GR ISGA++ AV +IN+    +   SL       S    ETYGE + SI   A++  +K + A IGPQETC  EA +A AFN+ MIS++C D+  T D   + TF RTRP  + ++  + + LK F W  V+   S+  +  F  I      V     I I   K   +  ++G   N F K+V +T+Q TRIYV +G+ ++  GL++A+ E  L   G YFVV + V + +A +   +    + ++       + R+F  +    P G   K  S K   +M +PPF   +            +E++YLYDAV LYA  V  +++      P++G  +       +YKS  GY  ++D  G+A GNYT+   Q   +A+    + P G F          E     N+ W+   P    P CG+ G+ C T+     + +    LL+++  +S    ++ +YE+EL+ LLWK+D  K+I+ ++ E     S I+R     I    V L    D+ F  +     +G               +YK +   +K V    +I ITR +KKELK +R++ + NLN F+GA  +  +  +V E+C+RGSL+D+L +  +  +  +F++S   D+IRG+++LH++P + +HG+LKSSNCLVDSRW +KLTDFG++EF        D P   +FL                  L + +PE+LR                                            C  + I+I F            QK D+YSF +I YELHS + PF  N+    S  +I+R++I  +     P+RP L LL        D ++ CW EN   RP  K I  + + +  G + N+ + M   M  Y  NLE  V +RT++L EEKK+ + LLY+MLP  VAEQL++  +V+AE FD V+IYFSDIVGFT ++   +PF+V++ LN LYT FD II+N++VYKVETIGD+YMVVSGLP +  D HA E+A MSL LLE + K F I    Y  + L+LRIG+HSGP CAGVVG + PRYCLFGDTVN  SRMES G+ALKIHCS      +  L  +   ERG++E+KGKG+V T+WL+G+
Sbjct:   22 VLGYLTGSRRRPGDI---GYSKPGRTISGAISLAVEEINAGLFKDKGHSL-------SFLVAETYGEESTSILETAEL-WKKNISAFIGPQETCLHEARMAAAFNLPMISYYCMDSD-TSDKTLFPTFARTRPPDTQISKSVAAVLKAFNWTQVTFFYSNAADTHFGKIASTISEVFSKSGIDITAKKTWNTHYLHGYTANPFVKLVADTYQDTRIYVVLGNYYDHTGLIVAMDEMDLFKNGEYFVVGVDVEQYDAENPGKYLTGMLSNKPDPILEKAFRSFFSVVPTPPRG--FKNFSVKVNEYMEKPPFQFPNPLVQLGGVKQISVEAAYLYDAVHLYARCVLEMIECGD--DPRNGSAMMAKFKGSHYKSALGYEVYMDENGDAEGNYTLVSRQRQSDASKGYGLFPAGRFTKLRNLTKNPELTLVVNVEWISGKPPVAEPACGYRGQKCITH-TAEILSIVAGTLLLVLAVISLVFYRNWKYEQELDSLLWKVD-YKDIEINDTENSSTSSKISRALHPLIRTSQVSLSSNPDADFRYSSIFTTVG---------------IYKGRVFAIKNVK-KKSIDITRAMKKELKVMRDLRHENLNGFIGACTDPPNICIVTEYCNRGSLKDILENEDVKLDN-MFVASLVADIIRGMLYLHDSP-LRYHGNLKSSNCLVDSRWVLKLTDFGLQEF---KKESEDFPH--HFLQHDFRLQKDDEVDCKCEGLLYISPELLR--------------------------------------------CYNSSIQISF----------GTQKGDVYSFSIILYELHSRKGPFGENHGLGVS--DILRKIIYYSQDGSNPFRPPLELLENNFDFVRDCLQDCWAENPDDRPDFKAIRVKLRPMRKGMRPNIFDNMMAMMEKYANNLEVLVDERTDQLVEEKKKTDALLYEMLPKYVAEQLKRGHKVQAENFDCVTIYFSDIVGFTSMSAESTPFQVVDFLNDLYTCFDSIIENYDVYKVETIGDAYMVVSGLPIKNGDMHAAEIATMSLHLLEAVKK-FQIRHRPY--DSLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTTSRMESTGQALKIHCSSECRTLLERLGGYQTTERGLVEMKGKGNVRTYWLVGE 1072

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A182V5M5 (Guanylate cyclase OS=Anopheles merus OX=30066 PE=3 SV=1)

HSP 1 Score: 594.349 bits (1531), Expect = 0.000e+0
Identity = 410/1139 (36.00%), Postives = 606/1139 (53.20%), Query Frame = 1

Query:  202 IIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINS--WAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSII--SSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSL-VLRLEAISDSAF--GNIQV--DSRSLRNFVIISHIEPEGQLIKTE-SSKFKYFMSRPPFNVESQDK--SNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQL----IINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDI-PECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYM--YFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            +  +GY+ G++  P   +  Y R G  ISGA+T A+ ++N   ++Q+          +++     ETYGE   SI+  A +   + V A +GPQETC  E  +A AFN+ MIS+FCT N  T + + + TF RTRP    ++  +VS L  + W  VS +  +SD+ E + + +   + L+  +I I           +G ++N F ++VE+T++ TRIY+ +G  +E  GLL++L  +GL D G+YFVV + + + +A   + +  G +Q   D  ++  F     I P   +   E + K   ++  PPFN  +             E++YLYDAV LYA  +  +L   S GSPK+G  + + +  R Y S  GY+ HID  G+A GNYT+          A  +  + PIG F       +  E +    I+WV   P    P CGF GE C  +             L+L+  VS  + ++ RYE+EL+ LLWK+D  +EI    +E +     +TR     I    V L    D  F  +     IG               +YK Q   +K+V    +I ITR++KKELK LR++ + NLN F+GA  +  +  ++ ++C+RGSL+DVL +  +  +  +F +S   D++RG+I+LH++P + FHG L++SNCL+DSRW VKL+DFG+  F       PD  E +      L + APE+                                               L A      P  P         K D+YSFG++ YE+ + + PF      + +P E ++R++   D    P+RP +  L  +     D +K CW E    RP  K I NR +VL  G + N+ + M   M  Y  NLE+ V +RT++L+EEKK+ E LL +MLP PVAEQL++  +VEAE++D V+IYFSDIVGFT ++   +P +V++ LN LYT FD II +++VYKVETIGD+YMVVSGLP +    HA E+A+MSL+LLE + +  V       N+RL LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES G+ LKIHCS      +  L  +   ERG++ +KGKG   TFWL+G+
Sbjct:   59 VFTVGYLTGSQRRPGDRV--YARPGLQISGAITLAMAEVNDRYFSQHG---------HELRFEVAETYGEEVTSIRKTADLWT-RDVIAYLGPQETCVHEGRMAAAFNLPMISYFCTHN-ETSNKKHFPTFARTRPPDLQISKSVVSLLLAYNWTQVSFLYRASDNGELDAVAETLKTTLRTASIRIRSVGTWTDIYHHGYSSNPFERLVEDTYEDTRIYLVLGYHYEHIGLLVSLRRRGLLDRGDYFVVGVDIDQYDAALPTKYMHGLLQTTPDPDAVEAFRHYLGIVPSAPVRFEEFAVKVNKYLELPPFNYRNALIFFGGVKQIRAEAAYLYDAVHLYANALMQVLV--SGGSPKNGSAIIEAIKGRAYISAMGYLVHIDENGDATGNYTILARKPVPSTGATNQYGLFPIGRFSSPTVDRIP-EIRLFDTIDWVGSGPPVAEPRCGFRGEKC-ISYTGEITGGIAGGALLLLGVVSLVLYRNWRYEQELDSLLWKVD-FREIQMHENEKVTAGQKMTRSTHPLIRTSQVSLSSNPDLDFRYSTIFTPIG---------------LYKGQLYAIKKVK-KKSIDITREMKKELKLLRDMRHDNLNAFIGACTDPPNICIITDYCNRGSLKDVLENEDVKLDN-MFTASMVADILRGMIYLHDSP-LRFHGSLRTSNCLIDSRWVVKLSDFGLFAFKQGSEEVPDEKEKLEEKCQKLLYRAPEL-----------------------------------------------LRAGPTATVPGTP---------KGDVYSFGIVLYEIFTRRGPF---GEIECTPMECLKRVLNPLDP-NTPFRPAIQPLETSFDCVRDCLKECWAERPEDRPDFKTIRNRLRVLRKGMRPNIFDNMMAMMEKYANNLEQLVDERTDQLQEEKKKTEALLLEMLPRPVAEQLKRGHKVEAESYDLVTIYFSDIVGFTSMSAESTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPIRNGLIHAAEIASMSLQLLEAVAEFKV---RHRPNDRLYLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGQPLKIHCSLQTKEILDSLGGYQFQERGLVPMKGKGDQRTFWLVGE 1098

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 400.208 bits (1027), Expect = 4.037e-120
Identity = 346/1106 (31.28%), Postives = 543/1106 (49.10%), Query Frame = 1

Query:  337 NSKESLLPSTYQISVHFVETYGEMNNSI--QAVAK-MSVEKKV----WAIIGP--QETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDD-----KENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYF-----VVSLVLRLEAISDSAFGNI--QVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEK-----KNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NS  SLLP     S+ FV    E  + I  +++A  M+V+ K     WA IGP    T          + + MI+        ++ S  Y++   T P    L  + +   + F W+  +++   D     +E  F ++   + LK  NIT +   LV       S    +++ ++   +  R+ VF+    +IF  LM  + K       +      V    L  + +   A G+   ++  ++ ++  I+++ EP+    K      K   ++  FN    D    S   + S   YD ++LY   +   L   S G P     + + + NR Y  V G +  ID  G+   ++ +  +    +   +I  + ++   +G+  +         +W    IP D+P CGF  +    I RT      + + +F +L+++  ++ F+ +  + EKEL   LW+I   +++  SN E + +                        S+  L+    N G +L  D          Y    +V  +      I +TRKV  ELK +R++   +L +F+GA I+  +  +V E+C RGSLQD+L +  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VD+R+ +K+TD+G+  F T   P+     + Y+    W AP++LR                                       SN  +C                     QK DIYSFG+I  E+   +  F     S  SPKEI+ R+ +     + PY RP ++  + +++    L++ CW E   +RP     ++  KVL  ++     +++++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LL+ + K F I      +++LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMESNGE LKIH S A    +   N F +  RG +E+KGKG + T+WL+G+
Sbjct:   81 NSNPSLLPG---YSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTV--DLVFEE---DSRPVNYSEHLQKIKEEGRV-VFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKA-GAKKMFNFTVDD----SLMNIISGGFYDGLMLYVQALNESLAE-SHGRPSS-KSITERMWNRTYYGVTGLV-QIDKHGDRETDFALWDMTDTNSSVFQI--VAVY---NGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRIS-WEDMQMSNLEKVLR---------------------SAGSKLTLSLRGSNYGSLLTADGNFQVFAKTAYFKGNIVAIKYVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDW-MFKYSLINDIVKGMAFLH-NSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPED---AHSYYARKLWMAPDLLR--------------------------------------MSNPPAC-------------------GTQKGDIYSFGIILQEVALRRGVFYIEGDSL-SPKEIVDRVAL----GEWPYLRPTVNTQAHSEELG-QLMQRCWAEEPAERPE----FSHIKVLLRKQNREVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAV-KTFKI--RHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1067

[Close]

Query:  337 NSKESLLPSTYQISVHFVETYGEMNNSI--QAVAK-MSVEKKV----WAIIGP--QETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDD-----KENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYF-----VVSLVLRLEAISDSAFGNI--QVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEK-----KNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NS  SLLP     S+ FV    E  + I  +++A  M+V+ K     WA IGP    T          + + MI+        ++ S  Y++   T P    L  + +   + F W+  +++   D     +E  F ++   + LK  NIT +   LV       S    +++ ++   +  R+ VF+    +IF  LM  + K       +      V    L  + +   A G+   ++  ++ ++  I+++ EP+    K      K   ++  FN    D    S   + S   YD ++LY   +   L   S G P     + + + NR Y  V G +  ID  G+   ++ +  +    +   +I  + ++   +G+  +         +W    IP D+P CGF  +    I RT      + + +F +L+++  ++ F+ +  + EKEL   LW+I   +++  SN E + +                        S+  L+    N G +L  D          Y    +V  +      I +TRKV  ELK +R++   +L +F+GA I+  +  +V E+C RGSLQD+L +  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VD+R+ +K+TD+G+  F T   P+     + Y+    W AP++LR                                       SN  +C                     QK DIYSFG+I  E+   +  F     S  SPKEI+ R+ +     + PY RP ++  + +++    L++ CW E   +RP     ++  KVL  ++     +++++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LL+ + K F I      +++LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMESNGE LKIH S A    +   N F +  RG +E+KGKG + T+WL+G+
Sbjct:   81 NSNPSLLPG---YSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTV--DLVFEE---DSRPVNYSEHLQKIKEEGRV-VFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKA-GAKKMFNFTVDD----SLMNIISGGFYDGLMLYVQALNESLAE-SHGRPSS-KSITERMWNRTYYGVTGLV-QIDKHGDRETDFALWDMTDTNSSVFQI--VAVY---NGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRIS-WEDMQMSNLEKVLR---------------------SAGSKLTLSLRGSNYGSLLTADGNFQVFAKTAYFKGNIVAIKYVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDW-MFKYSLINDIVKGMAFLH-NSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPED---AHSYYARKLWMAPDLLR--------------------------------------MSNPPAC-------------------GTQKGDIYSFGIILQEVALRRGVFYIEGDSL-SPKEIVDRVAL----GEWPYLRPTVNTQAHSEELG-QLMQRCWAEEPAERPE----FSHIKVLLRKQNREVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAV-KTFKI--RHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1067

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 379.793 bits (974), Expect = 4.598e-113
Identity = 341/1106 (30.83%), Postives = 527/1106 (47.65%), Query Frame = 1

Query:  337 NSKESLLPSTYQISVHFVETYGEMNNSI--QAVAK-MSVEKKV----WAIIGP--QETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDD-----KENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYF-----VVSLVLRLEAISDSAFGNI--QVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEK-----KNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            NS  SLLP     S+ FV    E  + I  +++A  M+V+ K     WA IGP    T          + + MI+        ++ S  Y++   T P    L  + +   + F W+  +++   D     +E  F ++   + LK  NIT +   LV       S    +++ ++   +  R+ VF+    +IF  LM  + K       +      V    L  + +   A G+   ++  ++ ++  I+++ EP+    K      K   ++  FN    D    S   + S   YD ++LY   +   L   S G P     + + + NR Y  V G +  ID  G+   ++ +  +    +   +I       + +G+  +         +W    IP D+P CGF  +    I RT      + + +F +L+++  ++ F+ +  + EKEL   LW+I   +++  SN E + +                        S+  L+    N G +L  D          Y    +V  +      I +TRKV  ELK +R++   +L +F+GA I+  +  +V E+C RGSL                       V+ G+ FLH N  I  HG+LKSSNC+VD+R+ +K+TD+G+  F T   P+     + Y+    W AP++LR                                       SN  +C                     QK DIYSFG+I  E+   +  F     S  SPKEI+ R + L +    PY RP ++  + +++    L++ CW E   +RP     ++  KVL  ++     +++++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LL+ + K F I      +++LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMESNGE LKIH S A    +   N F +  RG +E+KGKG + T+WL+G+
Sbjct:   61 NSNPSLLPG---YSLQFVFESSENTDGICSESIAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGFSDRSDAYTSITNTGPTHKKLGEFALHICRHFGWSQHALLMFGDSKMGERECYFAVEGLYTELKEVNITTV--DLVFEE---DSRPVNYSEHLQKIKEEGRV-VFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPWARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKA-GAKKMFNFTVDD----SLMNIISGGFYDGLMLYVQALNESLAE-SHGRPSS-KSITERMWNRTYYGVTGLV-QIDKHGDRETDFALWDMTDTNSSVFQI-----VAVYNGTQKQMRTLPGMAFHWPGGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRIS-WEDMQMSNLEKVLR---------------------SAGSKLTLSLRGSNYGSLLTADGNFQVFAKTAYFKGNIVAIKYVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSL-----------------------VLSGMAFLH-NSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESDPED---AHSYYARKLWMAPDLLR--------------------------------------MSNPPAC-------------------GTQKGDIYSFGIILQEVALRRGVFYIEGDSL-SPKEIVDR-VALGEW---PYLRPTVNTQAHSEELG-QLMQRCWAEEPAERPE----FSHIKVLLRKQNREVSRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAV-KTFKI--RHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1025

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 371.703 bits (953), Expect = 7.962e-110
Identity = 241/581 (41.48%), Postives = 336/581 (57.83%), Query Frame = 1

Query: 1852 CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFL--TYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-----GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            C YK     +K V     I +TRKV  ELK +R++   +LN+F+GA I+  +  ++ E+C RGSLQD++    +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNCLVDSR+ +K+TD+G+  F   +Y+    DT  + Y+    WTAPE++RD                    + R+     K DV                                     YSFG+I  EL   +  F  + S   SPKEI+  +     + + PY RP L   S +++    L++ CW E+  +RP     +N+ KV+      G   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H  E+A MSL LLE +   +        + +L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH SEA    +   N F +  RG IE+KGKG + T+WL+G+   N
Sbjct:  549 CYYKGNITAIKYVN-KKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDW-MFRYSLINDIVKGMAFLH-NSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFRKESYLE---DT--HAYYARKLWTAPELMRD--------------------ENRQPCGTQKGDV-------------------------------------YSFGIILQELALLKGVFYLD-SPPFSPKEIVEHVA----EGRWPYLRPLLCTQSHSEELG-QLMQRCWSEDVNERPD----FNQIKVMLHKNNRGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAV---YSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGESTSN 1051

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BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr2 (natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZDB-GENE-141030-2])

HSP 1 Score: 351.288 bits (900), Expect = 5.916e-103
Identity = 318/1024 (31.05%), Postives = 485/1024 (47.36%), Query Frame = 1

Query:  562 EDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSII-----SSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVDS-------RSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYL----YDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLIL--CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLE 3561
            ++S+ + T VRT P  + L +++ S    F W   +++       DD+ + F+ +     L A N+T+          +    N  + +IV    +S RI V+I    + F  +M+ +E+ + +T +Y +  L    E++S+ A       +       +  +N  +I+  EP+           +Y   R   +  +    N    P    Y+    YD  +LYAT +   L +    S  DG+ +   +LNR    V G ++  D     Y ++++  +     G+      G +   +G+  E  + + K I W   IP D P C  + E                 +L+    +S    +  + EKEL R+LW+I + +++ F +     K                        S+  L++   + G ++    G   L      +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQ               ++++A   + G+ +LH N  I  HG+LKSSNC+VDSR+ +K+TD+G+  F    S   +   +  +    WTAPE+                     LI +R                              PP   +      QK DIYSFG+I  E+     PF    +   SPKEII++  V N Q   PY    +  SR  ++   L++ CW E+ T+RP     ++  K+   +       +++  +  +M  Y  NLE  V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT          V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A MSL LLE++ K F I      N++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMES GEAL+IH S A    +     F +  RG +E+K K      WL  K E
Sbjct:  144 DNSEEFRTLVRTGPTTTKLGDFVNSLHAEFNWTRRALLIFHDLKRDDRPHFFLSEGIYINLLAENMTV--------EVLPYEDNTSYQEIVTFIRESGRI-VYICGPLQTFFNIMSTFEEEVKNTEDYAIFYLDAFGESLSNEAHQPWHTSAMQWKDPIKLFQNVFVITFREPDNP---------EYAAFRTELHKRATQDFNVQLEPSLMDYIAGCFYDGFVLYATALNEALADGV--SQNDGINITTRMLNRSIWGVTGLVS-TDQNNARYTDFSLWSMSNLTTGQYVA---GHY---NGTNKEIVW-SKKGIQWAKGIPIDDPRCLVSCE-------------GRSWVLLFFKGLSYIGNRKLKLEKELARMLWRI-KWEDLQFESPNKYHK---------------------RAGSRLTLSQRGSSYGSLISAH-GKHQLFAKTGYFKGNLVAIKHVN-KKRIELTRQVLFELKHMRDVQFNHLTRFVGACIDPPNICIVTEYCPRGSLQ---------------VNTYASCTLLGMNYLH-NSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFR---SSYDNEDSHELYARKLWTAPEL---------------------LIYDR------------------------------PPPQGT------QKGDIYSFGIILQEIALRNGPFYVE-AMDLSPKEIIQK--VRNGQ--RPYFRPTTDNSRHCEELTILMEGCWAEDPTERPD----FSHIKIFITKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRRAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTS--------NVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQV-KTFKI--RHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKEVLDEFGYFDLQLRGDVEMKVK------WLFLKEE 1000

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 369.007 bits (946), Expect = 1.107e-111
Identity = 272/776 (35.05%), Postives = 409/776 (52.71%), Query Frame = 1

Query: 1270 NRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVH-DIPRDIPECGFNGEICRTN--EKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQ-DVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            NR Y+ V G    ID  G+   ++++  L     GE  +    +   D  S    E    + I W    IP+D+P CGF  E C +        + +   ++L++V   S  + +  + EKEL  +LW++ R + I  S+ E   + +                      S+  L+    + G +L             Y    +V  +      I +TR+V  ELK +R++   +L +F+GA I+  +  +V E+C RGSLQ D+L +  +T ++ VF  S   D+++G++FLH N  I  HG LKSSNC+VDSR+ +K+TD+G+  F +  S   D   +  +    WTAPE+L                                                   +++ PP   +      QK D+YS G+I  E+      F        SPKEI+++  V N Q +  +RP        ++  + L++ CW E+  +RP     +++ K+L  +       N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + +A+E+A MSL LL+ + K F I     + ++LKLRIG+H+GP CAGVVG + PR+CLFGDTVN ASRMESNGEALKIH S+     +     F +  RG +E+KGKG + T+WL+G++E+N
Sbjct:  151 NRTYRGVTGEFT-IDRNGDRETDFSLWDLTDMNTGEFNV----VLSYDGASSKLIEVPGLE-IQWPGGSIPKDVPLCGFENEACISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRL-RWENIQVSSLEKARRSA---------------------GSKLTLSMRGSSCGSLLTTQGRNQMFAKTGYYRGNLVAIKPINKKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDW-VFRYSLINDIVKGMLFLH-NSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRS-CSECEDM--HSLYAKKLWTAPELL---------------------------------------------------RLEHPPPQGT------QKGDVYSLGIILQEIALRNGTFYVE-GMDLSPKEIVQK--VKNGQ-RPYFRPSTDESCHIEELGL-LMQRCWAEDPAERPD----FSQIKMLIHKFNKENSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAV-KTFKI--RHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGEIEEN 824

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002650.1 (pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 gene:ENSPMAG00000002416.1 transcript:ENSPMAT00000002650.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 256.529 bits (654), Expect = 9.472e-75
Identity = 148/343 (43.15%), Postives = 215/343 (62.68%), Query Frame = 1

Query: 2533 SDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNE-RLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            +D+YS+G+I  E+ + Q P  +   S +   E            +      +     +      LI+ CW  N   RPT + I      +   K + V+ M   M  Y+K+LE  V +RT++L  EK++ + LLY MLP  +A+ LRQ +  +A+++ S +++FSDIVGFT+L+   +P+EV++ LN+LYTSFD IIDN++VYKVETIGD+YMVVSG+PT+  ++HA E ANM+L L+  + + FVIP   +K E +LK+R G+H+GP  AGVVGT+ PRYCLFGDTVN ASRMES  EALKI CS +    +  +  + +  RG + VKGKG + T+WL G+
Sbjct:  159 TDVYSYGVILVEIATRQTPTPAGLYSPHDDAETEGPPPSPPPPIRPFIYKSVRCTIGSAYYYNKLIQKCWNHNPLLRPTFEQIKKFLHKMNPNKFSPVDMMMSLMEKYSKHLESVVTERTQDLVLEKQKTDRLLYSMLPKQIADDLRQGRVTKAQSYASATVFFSDIVGFTQLSSSSTPYEVVDFLNKLYTSFDGIIDNYDVYKVETIGDAYMVVSGVPTENHNQHAVETANMALDLV-NVCQAFVIP---HKPEMQLKIRAGIHTGPVVAGVVGTKMPRYCLFGDTVNTASRMESTSEALKIQCSPSTSSILQQIGSYLLSCRGTVTVKGKGEMITWWLEGR 497

HSP 2 Score: 105.145 bits (261), Expect = 1.329e-23
Identity = 49/117 (41.88%), Postives = 78/117 (66.67%), Query Frame = 1

Query: 1903 AISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPV---FLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREF 2244
            A ++T+ +++E+K +RE+ Y NL KF+G ++E  +  ++ E+C +GSLQDVL    L  + P+   F  SFA D+ RG+ FLH +    FHG LKS+NC++D RW  K+ D+G+ E+
Sbjct:   13 AFNLTKVIRREVKQVRELEYANLCKFIGGMVEVPNVAILTEYCPKGSLQDVL----LNDDIPLNWGFRFSFATDIARGMAFLHSHR--LFHGRLKSTNCVIDDRWVCKIADYGLEEY 123

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 255.758 bits (652), Expect = 1.585e-74
Identity = 156/357 (43.70%), Postives = 222/357 (62.18%), Query Frame = 1

Query: 2527 QKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVL---FGEKKN---------LVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            QK D+YSF +I  E+     PF    ++  + KEI++R+ +     + PY RP +     +++    L++ CW E +T+RP     +++ K+L   F  + +         +++ +  +M  Y  NLE+ V +RT+   EEK + E LLYQ+LP  VAEQL++ + V AEAFDSV+IY SDIVGFT ++   +P +V+  LN LYT FD IIDNF+VYKVETIGD+YMVVSGLP      HA E+A M+L LL  + + F I       +RL LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRME+ GEA +IH S      +     F +   G +++KGKG++ T+WL+G+
Sbjct:  160 QKGDVYSFAIILQEIALRSGPFYLE-ANHLTAKEIVQRVKL----GEWPYLRPTVDPGGHSEELG-HLMQRCWAEESTERPD----FHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAV-RCFHI--RHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGE 503

HSP 2 Score: 104.76 bits (260), Expect = 1.543e-23
Identity = 53/141 (37.59%), Postives = 90/141 (63.83%), Query Frame = 1

Query: 1906 ISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            I +TR++  ELK +R++   +L +F+GA I+  +  ++ E+C RGSLQD+L +  ++ ++ +F  S   D+++G+++LH +  I  HG+LKSSNC+VDSR+ +K+TD+G+     +           YF    WTAPE+LR
Sbjct:   15 IELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDW-MFRYSLMHDIVKGMLYLHSSV-IGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSKADSSAN---YFEKRLWTAPELLR 150

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000043.1 (pep scaffold:Pmarinus_7.0:GL480785:4349:14716:1 gene:ENSPMAG00000000040.1 transcript:ENSPMAT00000000043.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 243.047 bits (619), Expect = 9.303e-71
Identity = 174/507 (34.32%), Postives = 263/507 (51.87%), Query Frame = 1

Query: 2029 CDRGSLQDVLYSTKLTKEYPV----FLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYE-LHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSL---LSRTDKKQI-DLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFD-EHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFH-IVERGVIEVK 3516
            CD    QD+L       E  +    F  S   D+ +G+ +LH +  I  HG LKS+NC+VD R  VK+TDFG+      VS                     LRD I+ +   ++   SL LGL                                   P    L + + Q+ D+YSFG++  E L+  Q+ ++   S  +  K+I+ +L+      KV  RP L +   + +   +++  +I  CW+E   +RP    +++   +  G+ ++ V+ +  ++  Y+KNLE+ V +RTE  + E+ + + L YQ+LP  V + L+    V+ E F+ V+IYFSDIVGFT +   C P EV+ LLN LY  FD I+D+ +VYKVETIGD+YM+VSGLP +    HA E+AN++L +L  +    +   +      + +RIG+HSG C AGVVG + PRYCLFGDTVN ASRMES G   +IH S++ +  +      H    RG+IE+K
Sbjct:    2 CDLCGKQDILDDDVAYPEETLMDWDFKVSLMQDIAKGMAYLHSSK-ITVHGRLKSTNCVVDGRMVVKITDFGL------VS---------------------LRDEIRERDMGSEEANSLFLGLWT--------------------------------APELLPLRAGASQRGDVYSFGIVLQEILYRRQVFYIKGNSLTD--KDIVEQLL----SGKV-MRPTLDMNDFIHKGGGEELCAMITDCWEEVPDKRPDFPRVHHTRCIHKGKAESYVDSLIRRLEQYSKNLERLVEERTELYKRERDRADHLNYQLLPKTVVQALKSVGSVQPELFEEVTIYFSDIVGFTTICKHCEPMEVVCLLNDLYKEFDSIVDSHDVYKVETIGDAYMLVSGLPKRNGCHHAMEIANVALDILSFMGSFHI---QHLPGLPVWVRIGIHSGKCAAGVVGNKMPRYCLFGDTVNTASRMESTGYPYRIHVSQSTVDTLNAQQSGHQFTCRGIIELK 438

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 223.402 bits (568), Expect = 1.911e-61
Identity = 151/347 (43.52%), Postives = 208/347 (59.94%), Query Frame = 1

Query: 2530 KSDIYSFGMIFYEL--HSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVP-YRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKK-NLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFD-EHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            K D++SF ++  E+  H  + P++  +     PK+II ++    D   VP  RP L+   R + +   LI+ CW E+A +RP    +    ++   E   N+++ M  K+  Y  +LE+ V  RT +L  EKK+ + LL  +LP  V +QL+  K V+ E ++ V+I+F DIVGFT ++   +P EVINLLN LY   D II  ++VYKVETIGD+YMV SGLP +    H  E+A MSL  L  I   F I       E+LKLRIG++SGP  AGVVG   PRYCLFGDTVN+ASRMES G  L IH SEA    +  +  + +VERG I +KGKG+  T+WL GK
Sbjct:  382 KGDVFSFAILMREVIYHEDEGPYVGIHLE---PKDIIDQV---RDGIAVPPLRPLLT--ERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMN-FRI--RHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717

HSP 2 Score: 121.324 bits (303), Expect = 3.142e-28
Identity = 117/409 (28.61%), Postives = 194/409 (47.43%), Query Frame = 1

Query: 1156 SSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNH--IDNKGEAYGNYTVNQLI--INANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHD-IPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXX-------KSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSN--LILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEY----MYFLSLFWTAPEILR 2328
            ++YL+DA +LYA  V  +L+    G+P+DG  + + +        +G      ID  GE + +Y V  L     A GEM+I     F       + F  +  K + W     P D+PECGF GE+C+           + +  IL + V   V        +S+  ++ ++   WKI+               F  IT  P+    NG+        S   ++ +  N+ H +    GT    + + +Y+  +V +K  +         K  +    +RE+ + NL  F G  +E  +  +V ++C +GSL+DVL ++    ++ +F +SFA D++ G+IFLH++P I  HG+LK S CL+DSR  +KLT FG+ EF      +  T +      +F+ L+WTAPE+LR
Sbjct:    1 AAYLHDAGILYAMAVRELLRQG--GNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTF---QTINFTPEYQK-MGWPDGRPPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTVAFLTYLVVQSRSLQESMDTTWWKIN---------------FEDITLVPLV---NGSY-----RSSSKQVSGNQSNVHHDVH---GTDRVEIPIGIYQGNQVALK--FLERTHPPDLKSNRFALKMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDW-MFKTSFAHDIVNGMIFLHKSP-IKSHGNLKPSTCLLDSRLQIKLTGFGIWEF--RYGKKGKTLDINNLGSFFIELYWTAPELLR 371

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CLA4 (Cdc42p-activated signal transducing kinase; member of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p; CLA4 has a paralog, SKM1, that arose from the whole genome duplication [Source:SGD;Acc:S000005242])

HSP 1 Score: 58.5362 bits (140), Expect = 5.422e-9
Identity = 41/138 (29.71%), Postives = 67/138 (48.55%), Query Frame = 1

Query: 1933 ELKTLREISYVNLNKFMGAIIEHQDT-WVVWEFCDRGSLQDVL--YSTKLTKEYPVFLSSFAF---DVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            E+  +++  + N+  F+ A +   D  WVV EF + GSL D++    T      P+     A+   +  +GL FLH+      H  +KS N L+D+R  VK+TDFG    LT       +       + +W APE+++
Sbjct:  610 EILVMKDSRHKNIVNFLEAYLRTDDDLWVVMEFMEGGSLTDIIENSPTNDNSHSPLTEPQIAYIVRETCQGLKFLHDK--HIIHRDIKSDNVLLDTRARVKITDFGFCARLT----DKRSKRATMVGTPYWMAPEVVK 741

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIC1 (Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144])

HSP 1 Score: 58.5362 bits (140), Expect = 5.785e-9
Identity = 42/171 (24.56%), Postives = 84/171 (49.12%), Query Frame = 1

Query: 1852 CMYKNQEVVVKRVYFSLAISI------TRKVKKE---LKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMI 2337
             +YK   V   RVY    +++         V++E   L +L++IS  N+ ++ G+ ++    W++ E C  GSL+ +L   K+ ++Y   +     +++  L  +H+  D   H  +K++N L+ +   VKL DFG+   +   S +  T       + +W APE++ + +
Sbjct:   36 VVYKGYNVKTGRVYAIKVLNLDSDSDEVEDVQREIQFLASLKQIS--NITRYYGSYLKDTSLWIIMEHCAGGSLRSLLRPGKIDEKY---IGVIMRELLVALKCIHK--DNVIHRDIKAANVLITNEGNVKLCDFGVAAQVNQTSLRRQT----MAGTPYWMAPEVIMEGV 195

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: MRK1 (Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication [Source:SGD;Acc:S000002237])

HSP 1 Score: 55.8398 bits (133), Expect = 2.752e-8
Identity = 57/246 (23.17%), Postives = 107/246 (43.50%), Query Frame = 1

Query: 1609 KRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISY---VNLNKFMGAIIEHQDTWV--VWEFCDRGSLQDVLYSTKLTKEYP-VFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVD-SRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEIL 2325
            K  E+ + + ++K DR  ++D  NH      S+    P  E+                       +GH     +G     + +  NQ+V +K+V     +   R   +EL+T++ + +   V L  +     E  + ++  V ++  +   Q + +   L  + P V +  +A+ + + L +LH  P IC H  +K  N LVD + ++ K+ DFG  + L     +PD P   Y  S ++ APE++
Sbjct:  132 KTKERTIHKRVYKHDRKTDVDRKNHGGTIDISY----PTTEV-----------------------VGH---GSFGVVVTTVIIETNQKVAIKKV-----LQDRRYKNRELETMKMLCHPNTVGLQYYFYEKDEEDEVYLNLVLDYMPQSLYQRLRHFVNLKMQMPRVEIKFYAYQLFKALNYLHNVPRIC-HRDIKPQNLLVDPTTFSFKICDFGSAKCL-----KPDQPNVSYICSRYYRAPELM 336

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 55.8398 bits (133), Expect = 3.745e-8
Identity = 34/135 (25.19%), Postives = 75/135 (55.56%), Query Frame = 1

Query: 1924 VKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            ++ E+  L+E+ + N+  + GA  E  +  +  E+   GS+  +L +    +E    +++F   ++ G+ +LH+   I  H  +K +N L+D +  VK+TDFG+ + L+ ++ + +    +   S+FW +PE+++
Sbjct:  501 LQHEMNLLKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNYGPFEES--LITNFTRQILIGVAYLHKKNII--HRDIKGANILIDIKGCVKITDFGISKKLSPLNKKQNKRASLQG-SVFWMSPEVVK 630

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: SPS1 (Putative protein serine/threonine kinase; localizes to the nucleus and cytoplasm; required for efficient spore packaging, prospore membrane development and closure and localization of enzymes involved in spore wall synthesis; interacts with and required for Ssp1p phosphorylation and turnover; member of the GCKIII subfamily of STE20 kinases; multiply phosphorylated on S/T residues; interacts with 14-3-3 proteins, Bmh1p and Bmh2p; expressed at the end of meiosis [Source:SGD;Acc:S000002931])

HSP 1 Score: 55.0694 bits (131), Expect = 4.416e-8
Identity = 39/137 (28.47%), Postives = 68/137 (49.64%), Query Frame = 1

Query: 1924 VKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVL---YSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEIL 2325
            + +E+  L E+    +  ++  ++E    W+V E+C  GS  D+L   Y   L +E   F+     +V  GL +LHE   I  H  +K++N L++    VKL DFG+   +     + DT    +  + +W APE++
Sbjct:   61 LAQEIFFLAELKSPLITNYIATMLEDVSMWIVMEYCGGGSCSDLLKRSYVNGLPEEKVSFI---IHEVTLGLKYLHEQRKI--HRDIKAANILLNEEGMVKLGDFGVSGHIRSTLKR-DT----FVGTPYWMAPEVV 187

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80])

HSP 1 Score: 363.999 bits (933), Expect = 8.962e-113
Identity = 226/562 (40.21%), Postives = 322/562 (57.30%), Query Frame = 1

Query: 1903 AISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF---GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNE-RLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQNIS 3573
             I I+R++  E+K +R+I + NLN+F+GA +   +  +V ++C RGSLQD+L +  +  +  VF++S   D+++G+ +LH N DI  HG+LKSSNCLVDSRW +K+TD+G+   L     +  T E  +   L W APEILR                    I  R     +K DV                                     YSF +I  E H+   P+ +NY     PK II +  V   +F  PYRP ++ L    ++  DL+K CW E+   RP    I    + +    G KKN+ + M   M +Y  NLE  V +RT++L +EK++ + LL  +LP PVAEQL++ K VEAE+F+ V+IYFSDIVGFT L+   +P +V+  LN LYT FD II  ++VYKVETIGD+YMV SGLP +    HA E+A M+L L++ ++  F++   ++K E +L+LR+G H+GP  AGVVG    RYCLFGDTVN ASRMESNGE L+IH S+     +  L  F +  RG + +KGKG+V TFWL+  +++N S
Sbjct:   12 TIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDL-VFIASLLSDIVKGMEYLH-NSDIRSHGNLKSSNCLVDSRWVLKITDYGLP--LLRSRSKKSTIETNW-RDLLWVAPEILR--------------------IPSRPPKGTHKGDV-------------------------------------YSFSIILQEFHTRDGPYSANYM---EPKAIIEK--VRKSEFP-PYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIV---RHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWLVSTVDKNES 502

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36182 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA4])

HSP 1 Score: 340.117 bits (871), Expect = 9.395e-105
Identity = 202/565 (35.75%), Postives = 319/565 (56.46%), Query Frame = 1

Query: 1936 LKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLS--LLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK--LEQNISNIDSIKFVHSHSYK 3615
            +K +R++ + NLN+++G  +E  +  +V  FC+RG+LQD+L +  +  ++ +F  SFA D+  G+  +H +P I  HG+LKSSNCL+DSRW  K+TD+G+       +P+ D  E+  + +LFWTAPE+L                     + +  +  +NKT                                  Q  D+YS+G++ YE+ +   P+ +N  + +S K++I    ++  + +  +RP+ S  +  ++  K + + + CW  +A +RPT   I  + K   G     +  M  +   Y  N  K V+ R       K+        +L  P+A++L++   V AE+F SV+I+FSDIVGFT +A   +P +V++LLNQLYT FDK++D  +VYKVETIGD+YMVVSGLP +  E HA E+A+M+L LL E+ + F IP     + +++LRIG+HSG C AGVVG + PRYCLFGDTVN ASRMES+G AL+IH S      +  L  +H+ ERG + +KGKG++ T++L GK   ++ + ++     +  H +K
Sbjct:    1 MKMVRDLHHANLNRYLGVCVESPNICMVSRFCNRGTLQDLLGNDSIKLDW-MFRQSFANDIATGMEAIHNSP-IQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPK-DIGEFAVYKNLFWTAPELLP--------------------LADGFKDRKNKT----------------------------------QAGDVYSYGIVLYEIITRDEPYSTNTDTLSS-KDVIE---LVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLKA-NGMGNGKISGMFSR---YYNNFSKLVISRMGVCMALKRLL------VLSRPIADELKKGNSVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEV-RDFQIP--HIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMKGKGTIVTYFLTGKDGFDKPLPDVRYAAALADHEFK 491

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9])

HSP 1 Score: 338.961 bits (868), Expect = 6.017e-104
Identity = 214/568 (37.68%), Postives = 320/568 (56.34%), Query Frame = 1

Query: 1855 MYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDES-CLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIG 3552
            +YK+  V +KR+     I +TR++K E+K +R + + NL  F GA +E  +  ++ ++C +GSLQD+L +  + K   +F++S   D+++G+ +LH   +I  HG LKS NC+VD RW +K+TD+G+ +F +      +  EY  +    WTAPE+LR     +    Q       G+I +   +     D+  S ++N+ S  +E   +++ PP    L +I  +   +              I  L+ +  + +P                 +RP    + +T +                           K+  G++ N+++ M   +  Y  NLE  V +RT +L +EK++ E LL +MLP  VA+ L   KQV AE FD VSI+FSDIVGFT L+   +P +V++LLN LYT FD+II+N++VYKVETIGD+YMVVSGLP +   +HA E+A M+L +L EI   F I      N++LKLRIG+HSG C AGVVG + PRYCLFGDTVN ASRMESNGEALKIH S +    +  L  +HI +RG + +KGKG+  T+WL+G
Sbjct:   13 IYKSNMVAIKRIN-KRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDI-KLDSMFVNSLLTDIVKGMAYLHST-EIRSHGRLKSPNCVVDGRWVLKITDYGLNKFKSNQDISEEEGEYAMYYRKLWTAPELLR-AADPRPRGTQKGDVYSFGIIVQELLTRSGPFDL--SYYTNEPSDIIEKVTRVESPPFRPKLSTIVLEGPTV------------AGIVDLAKWCWEENPD----------------HRPDFEEIRKTVR---------------------------KLPMGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREI-DSFKI--RHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVG 516

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO27923 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7T7X3])

HSP 1 Score: 319.701 bits (818), Expect = 4.221e-98
Identity = 193/480 (40.21%), Postives = 283/480 (58.96%), Query Frame = 1

Query: 2089 VFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLS--LLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKV-LFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVK 3516
            +F  SFA D+  G+  +H +P I  HG+LKSSNCL+DSRW  K+TD+G+       +P+ D  E+  + +LFWT PE+L                L  G      + H+NKT                                  Q  D+YS+G++ YE+ +   P+ +N  + +S K++I    ++  + +  +RP+ S  +  ++  K + + + CW  +A +RPT   I  + K    G+  N+V+ M   M  YT  LE  V +RT++L EEK + +ELLY+MLP P+A++L++   V AE+F SV+I+FSDIVGFT +A   +P +V++LLNQLYT FDK++D  +VYKVETIGD+YMVVSGLP +  E HA E+A+M+L LL E+ + F IP     + +++LRIG+HSG C AGVVG + PRYCLFGDTVN ASRMES+G AL+IH S      +  L  +H+ ERG + +K
Sbjct:   13 MFRQSFANDIATGMEAIHNSP-IQAHGNLKSSNCLIDSRWACKITDYGLDLLRANQTPK-DIGEFAVYRNLFWTVPELL---------------PLADGF-----KDHKNKT----------------------------------QAGDVYSYGIVLYEIITRDEPYSTNTDTLSS-KDVIE---LVRKRQEPAFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKLKANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEV-RDFQIP--HIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1])

HSP 1 Score: 307.375 bits (786), Expect = 1.673e-92
Identity = 190/507 (37.48%), Postives = 282/507 (55.62%), Query Frame = 1

Query: 1903 AISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNG 3420
            ++++TR +  E+K +R++ + NL  ++G      +  +V ++C RGSLQ++L + +++ ++  F  SFA D+  G+  +H +  I  HG L+SS CL+DSRW  K+ DFG+        P P+   +  +  LFW APE+L++    KS N                                              P P        Q  D+YSFG+I  EL + + P+ +   ++ +P E+I R+         P+RP+     R ++    L+  CW ++   RPT   I  + ++L G K ++V+ M   M  YT+ LE  V +RT +L +EK + +ELLY+MLP  +AE L++ + V AE++ SV+I+FSDIVGFTELA   +P +V++LLN LYT FD IID  +VYKVETIGD+YMVVSGLP +    HA E+A M+L LL  +       +    N  + LRIG+H+G C AGVVG + PRYCLFGDTVN ASRMES G
Sbjct:   79 SLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDW-FFRESFANDIAMGMHVIHTS-SIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQYSRLFWRAPELLQN---EKSTNK---------------------------------------------PVPT-------QMGDVYSFGIILNELLTREEPYAT---TEFAPIEVIERIRC---HLNPPFRPETPFEIR-NRSVTKLMTQCWNDDPQARPTFSDIKRQLRLLKGGKSSIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGN---FRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTG 518

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799])

HSP 1 Score: 392.889 bits (1008), Expect = 1.808e-117
Identity = 355/1157 (30.68%), Postives = 567/1157 (49.01%), Query Frame = 1

Query:  190 RNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSI--QAVAKMSV-----EKKVWAIIGPQETCRTEADIAMAF----NILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNA-VSIISSDDKENE----FILQNCLSVLKAHNITILHNKLVMS-PAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDS-----AFGNIQ--VDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDI-PRDIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-----KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            +N T+ II     T YP       + R    I  AL  A+ KINS        +LLP+ +   + +V    E +N I  ++VA +         K WA IGP   C   A     F    ++ +I+         +    Y T   T P    L  + +   + F W   V+++ SD+KE++    F ++     LK+ NI++  +    + P I       +++I+ +     R+ +F+    ++F  LM  + K   D  +   V L + L A+S S     A G+    +   + ++  I+S+ EP+ Q  +      K   ++  FN   QD    S   + +   YD ++LYA  +      P    P  G L+   + NR +  V G + H+D  G+   ++ +  L+   +   +I  + ++   +  V         ++ W+    P D+P+CGF  +    + +T      + ++LF +  + + ++ F+ +  + EKEL   LW+I    +I  SN +             K + +G         S+  L+    N G ++  +          Y    +V  +      I + RKV  ELK +R++   +L +F+GA ++  +  ++ E+C RGSLQD+L +  +T E+ +F  S   D+++G++FLH N  I  HG LKSSNC+VD+R+ +K+TD+G+  F        D+  + Y+    W APE+L                                                   +++ PP   +      QK D+YSF +I  E+   +  F  +     SPKEI+ R ++L D   +  RP +   S + +    L++ CW E  T+RP     +N  ++L  +     + N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSVSIYFSDIVGFT L+   +P EV+ LLN LYT FD +IDNF+VYKVETIGD+YMVVSGLP +  + H RE+A M+L LL+ + + F I       ++LKLRIG+HSGP CAGVVG + PRYCLFGDTVN +SRMES+GEALKIH S A    ++  N F +  RG I++KGKG + T+WL+G+
Sbjct:   43 QNITLAIILPETNTAYP-----WAWPR----IGPALERAIIKINS------DPNLLPNHH---LTYVFKSSENSNGICSESVAPLVAVDLEFAYKPWAFIGP--GCSYTASPVGLFTTHWDVPLITAGAPAIAFLDGI--YPTITNTGPTHKKLGRFALRICEHFGWREYVTLMFSDNKEDDRPCYFAMEGLYEELKSINISLQDSVFEENKPPI------NYSQILADIQNIGRV-MFVCCSPDVFRRLMIEFWKA--DLPHEQYVFLYIDLFAVSLSNKQPWARGDQDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKA-DAKTSFNYSVQD----SLMNIIAGGFYDGLMLYAHALNETALVPGARPP--GKLISGKMWNRTFHGVTGLL-HLDVSGDRETDFALWDLVDTNSSSFQI--VVVYNSFEEQVTPVP---GTSVRWLGGARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRIS-WDDIQMSNLD-------------KVLRSG---------SRITLSLRGSNYGSLMTANGNLQVFAKTGYYKGNIVAIKYTNKKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEW-MFKFSLINDIVKGMVFLH-NSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFRQESDVGSDS--HSYYAQKLWMAPELL---------------------------------------------------RMENPPPQGT------QKGDVYSFSIILQEVALRRGAFYLD-GDPLSPKEIVDR-VILGDWPCL--RPSIDPQSHSPELG-QLMQRCWAEEPTERPD----FNHIRLLLRKHNKESRTNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTV-RTFRI--RHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGE 1059

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 360.533 bits (924), Expect = 2.644e-106
Identity = 237/568 (41.73%), Postives = 331/568 (58.27%), Query Frame = 1

Query: 1858 YKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ FLH +   C HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D    +Y   L WTAP                                                  E  I    PP          QK D+YSFG+I  E+     PF    S   SPKEI+++  V N Q +  +RP       +++  I L++ CW E+  +RP    I      L  E   +++  +  +M  Y  NLE  V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A+MSL LLE++ K F I      N++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH S A    +     F++  RG +E+KGKG + T+WL+G+
Sbjct:  500 FKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRYSLINDIVKGMNFLHNSYFGC-HGNLKSSNCVVDSRFVLKITDYGLASFRS--SCENDDSHALYAKKL-WTAP--------------------------------------------------ELLIYDHHPPQ-------GTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQK--VRNGQ-RPYFRPTTDSRFHSEELTI-LMEGCWAEDPAERPDFGHIKIYMAKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQV-KTFKI--RHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 996

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 359.762 bits (922), Expect = 1.299e-105
Identity = 237/568 (41.73%), Postives = 331/568 (58.27%), Query Frame = 1

Query: 1858 YKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGE-KKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
            +K   V +K V     I +TR+V  ELK +R++ + +L +F+GA I+  +  +V E+C RGSLQD+L +  +  ++ +F  S   D+++G+ FLH +   C HG+LKSSNC+VDSR+ +K+TD+G+  F +  S + D    +Y   L WTAP                                                  E  I    PP          QK D+YSFG+I  E+     PF    S   SPKEI+++  V N Q +  +RP       +++  I L++ CW E+  +RP    I      L  E   +++  +  +M  Y  NLE  V +RT+   EEK++ E LLYQ+LP  VAEQL++ + V+AEAFDSV+IYFSDIVGFT ++   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + HARE+A+MSL LLE++ K F I      N++L+LRIG+H+GP CAGVVG + PRYCLFGDTVN ASRMESNGEALKIH S A    +     F++  RG +E+KGKG + T+WL+G+
Sbjct:  552 FKGNLVAIKHVN-KKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDW-MFRYSLINDIVKGMNFLHNSYFGC-HGNLKSSNCVVDSRFVLKITDYGLASFRS--SCENDDSHALYAKKL-WTAP--------------------------------------------------ELLIYDHHPPQ-------GTQKGDVYSFGIILQEIALRNGPFYVE-SMDLSPKEIVQK--VRNGQ-RPYFRPTTDSRFHSEELTI-LMEGCWAEDPAERPDFGHIKIYMAKLNKEGSTSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQV-KTFKI--RHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 1048

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 294.278 bits (752), Expect = 5.438e-83
Identity = 176/354 (49.72%), Postives = 233/354 (65.82%), Query Frame = 1

Query: 2527 QKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-----GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            QK D+YSFG+I  EL   +  F  +  +   PKEII+ +I    +  VP  RP L   S +++  + L++ CW E   +RP     +N  K+L      G   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VA+QL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A M+L LL+ + K F I      +++L+LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES GEALKIH SEA    +   N F +  RG IEVKGKG + T+WL G+   N
Sbjct:  655 QKGDVYSFGIILQELALLKGVFYIDTHTL-IPKEIIQGVI----RGGVPLLRPSLCFHSHSEELGV-LMQRCWCEEPGERPD----FNTIKILLRKQHRGYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAV-KSFKI--RHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDNSN 995

HSP 2 Score: 112.464 bits (280), Expect = 1.285e-24
Identity = 92/327 (28.13%), Postives = 164/327 (50.15%), Query Frame = 1

Query: 1372 GEMKIDPIGLFKLDDGSVLEFEFKN---NKNINWVHDIPR-DIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            G+ +ID   L+ + D +  +FE K+     N  W    P  ++PECGF  +    +  T      + + +  + +++I ++ F+ +  + E EL   LW++  + +I  SN + + +                 C      S+  ++    N G ++  +          Y    +V  +      I +TR V  ELK +R++   +L +F+GA ++  +  ++ E+C RGSLQD++ S  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VDSR+ +K+TD+G++   T   P  DT  + Y+    WTAPE+LR
Sbjct:  347 GDREID-FALWDMTDINSGKFEVKHLPKGLNFQWPGGSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWV-DIQMSNLDKVLR---------------RAC------SRLTISMKGSNYGSLMTMEGNLQIYTKTGYYKGNLVAIKYINKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDW-MFRYSLINDIVKGMTFLH-NSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSSCPD-DT--HAYYARKLWTAPELLR 645

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 294.664 bits (753), Expect = 8.384e-83
Identity = 176/354 (49.72%), Postives = 233/354 (65.82%), Query Frame = 1

Query: 2527 QKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPY-RPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLF-----GEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDE-HAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQN 3567
            QK D+YSFG+I  EL   +  F  +  +   PKEII+ +I    +  VP  RP L   S +++  + L++ CW E   +RP     +N  K+L      G   N+++ +  +M  Y  NLE+ V +RT+   EEK++ E LLYQ+LP  VA+QL++ + V+AEAFDSV+IYFSDIVGFT L+   +P +V+ LLN LYT FD IIDNF+VYKVETIGD+YMVVSGLP +  + H RE+A M+L LL+ + K F I      +++L+LRIG+HSGP CAGVVG + PRYCLFGDTVN ASRMES GEALKIH SEA    +   N F +  RG IEVKGKG + T+WL G+   N
Sbjct:  714 QKGDVYSFGIILQELALLKGVFYIDTHTL-IPKEIIQGVI----RGGVPLLRPSLCFHSHSEELGV-LMQRCWCEEPGERPD----FNTIKILLRKQHRGYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAV-KSFKI--RHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGEDNSN 1054

HSP 2 Score: 139.043 bits (349), Expect = 1.010e-32
Identity = 166/718 (23.12%), Postives = 308/718 (42.90%), Query Frame = 1

Query:  283 ISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKV----WAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNA-VSIISSDDKENE------FILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFG--------NIQVDSRSLRNFVIISHIEPEG-------QLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIIL--KNPSL---GSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPR-DIPECGFNGE----ICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILR 2328
            ++ AL  AV+ +NS         LLP      VH      E   S  A   ++V+ K+    WA IGP   C   +     F         T     +   +++    T P    L  + +   + F W+    +I SD+K++       F ++   S++  HNIT+           Y   +N  +K +    Q     V++   ++    LM  + K   D  NY    + L  E +     G        +      + R+  +++++EP+        + +K ++ K         FN   +D    S   + +   YD V+LY+  +   L  + P L     PK  M+ +++  NR ++ V G +  +D  G+   ++ +  +    +G+ ++       + + S+ E   +   N  W    P  ++PECGF  +    +  T      + + +  + +++I ++ F+ +  + E EL   LW++  + +I  SN + + +                 C      S+  ++    N G ++  +          Y    +V  +      I +TR V  ELK +R++   +L +F+GA ++  +  ++ E+C RGSLQD++ S  +T ++ +F  S   D+++G+ FLH N  I  HG+LKSSNC+VDSR+ +K+TD+G++   T   P  DT  + Y+    WTAPE+LR
Sbjct:   50 VAPALYRAVDSVNS------DPHLLPGLKLQLVHGSSENREGFCSDSAAPLVAVDLKLSHDPWAFIGP--GCDYSSSPVARFTTHWDVPMVTAGARADGFSKFAAVTNTGPTHKKLGEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCYFAIEGLYSLMGKHNITVFD---------YFVESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWFRGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKM--------FNFTIKD----SLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMW-NRTFQGVMGTV-EMDKFGDREIDFALWDMTDINSGKFEV-----VCVYNSSIKELVLQKGLNFQWPGGSPPLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWV-DIQMSNLDKVLR---------------RAC------SRLTISMKGSNYGSLMTMEGNLQIYTKTGYYKGNLVAIKYINKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDW-MFRYSLINDIVKGMTFLH-NSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSSCPD-DT--HAYYARKLWTAPELLR 704

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000041839.1 (SMESG000041839.1)

HSP 1 Score: 2357.79 bits (6109), Expect = 0.000e+0
Identity = 1212/1228 (98.70%), Postives = 1212/1228 (98.70%), Query Frame = 1

Query:   58 MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKWNAVSIISSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMXXXXXXXNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDIPECGFNGEICRTNEKXXXXXXXXXXXXXXXXXXXXXXXKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQNISNIDSIKFVHSHSYKSNSEISSDGLMLXXXXXXXXXXXXXXXMKENTYKTKFQKRDL 3741
            MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQ                WNAVSIISSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMLLKKLLLNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDIPECGFNGEICRTNEKFISIPVSLFILLILVIFVSAFVIKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTEELREEKKQNEELLYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQNISNIDSIKFVHSHSYKSNSEISSDGLMLEKSFKGKSKNNFFEKMKENTYKTKFQKRDL
Sbjct:    1 MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQ----------------WNAVSIISSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKFNKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRLEAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPFNVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMLLKKLLLNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFKLDDGSVLEFEFKNNKNINWVHDIPRDIPECGFNGEICRTNEKFISIPVSLFILLILVIFVSAFVIKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSFITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTEELREEKKQNEELLYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLEQNISNIDSIKFVHSHSYKSNSEISSDGLMLEKSFKGKSKNNFFEKMKENTYKTKFQKRDL 1212

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000041839.1 (SMESG000041839.1)

HSP 1 Score: 389.808 bits (1000), Expect = 2.831e-127
Identity = 185/185 (100.00%), Postives = 185/185 (100.00%), Query Frame = 1

Query:   58 MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVS 612
            MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVS
Sbjct:    1 MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTIIIIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLLPSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIAMAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVS 185

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000039747.1 (SMESG000039747.1)

HSP 1 Score: 371.318 bits (952), Expect = 1.385e-109
Identity = 231/576 (40.10%), Postives = 339/576 (58.85%), Query Frame = 1

Query: 1855 MYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYEL-HSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFK-VPYRPKLSLLSRTDKKQID-LIKLCWQENATQRP---TAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLE 3561
            +YKN  V +K +  +  I I + +  ++K +++++  ++ +F+GA +E Q   ++ E+C +GSLQDVL + ++  ++ +F  S   D+ RG+I+LH N  I  HG+LKSSNCL+DSR+ VKLTDFG+++         +   Y ++ +L WTAPEILR                                        N  S +E  +K                  DIYSF +I  E+ +   + +L  + +   P+EI+ R+     QF+ +P+RP L   S     +ID +IK  W+E   QRP     KV++ +F    G+  N+++ +  +M  Y  NLE  V +RTE+  EEK++ E+LLY MLP  VA QL +++ V AE+++SV+IYFSDIVGFT L+   +P +VI LLN LYT+FD I++N++VYKVETIGD+Y+VVSGLP +  + HARE++ MSL  L  +   F IP    ++ +L +RIG+HSGP CAGVVG + PRYCLFGDTVN ASRMESNG+A+KIH S   +  +     F I ERG IE+KGKG   T+WL G+ E
Sbjct:  576 VYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDW-IFKFSLIQDICRGMIYLHSN--IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILR----------------------------------------NSNSLVEGTVK-----------------GDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERV----KQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKA-GDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFT-FQIPHR--QDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 1083

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000039747.1 (SMESG000039747.1)

HSP 1 Score: 371.318 bits (952), Expect = 2.154e-109
Identity = 231/576 (40.10%), Postives = 339/576 (58.85%), Query Frame = 1

Query: 1855 MYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYEL-HSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFK-VPYRPKLSLLSRTDKKQID-LIKLCWQENATQRP---TAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQ-FDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGKLE 3561
            +YKN  V +K +  +  I I + +  ++K +++++  ++ +F+GA +E Q   ++ E+C +GSLQDVL + ++  ++ +F  S   D+ RG+I+LH N  I  HG+LKSSNCL+DSR+ VKLTDFG+++         +   Y ++ +L WTAPEILR                                        N  S +E  +K                  DIYSF +I  E+ +   + +L  + +   P+EI+ R+     QF+ +P+RP L   S     +ID +IK  W+E   QRP     KV++ +F    G+  N+++ +  +M  Y  NLE  V +RTE+  EEK++ E+LLY MLP  VA QL +++ V AE+++SV+IYFSDIVGFT L+   +P +VI LLN LYT+FD I++N++VYKVETIGD+Y+VVSGLP +  + HARE++ MSL  L  +   F IP    ++ +L +RIG+HSGP CAGVVG + PRYCLFGDTVN ASRMESNG+A+KIH S   +  +     F I ERG IE+KGKG   T+WL G+ E
Sbjct:  599 VYKNGIVAIKPIMHTKKIEINKSLLIQVKKVKDLNNDHICRFIGACLEPQHMCILSEYCPKGSLQDVLENDQIKLDW-IFKFSLIQDICRGMIYLHSN--IGPHGNLKSSNCLIDSRFVVKLTDFGLQKLRGSKDHLLEENPYAFYRNLLWTAPEILR----------------------------------------NSNSLVEGTVK-----------------GDIYSFAIILQEIIYRNGVFYLGEFETPIEPQEIVERV----KQFRQIPFRPYLGKESENHGSEIDSIIKQMWEEFPLQRPEMRNIKVMFRKFNKA-GDSGNILDNLLSRMEQYANNLEGLVTQRTEQYLEEKRKAEDLLYLMLPKSVARQLIRNEPVTAESYESVTIYFSDIVGFTSLSAESTPMQVIELLNHLYTTFDSILENYDVYKVETIGDAYVVVSGLPQRNGNLHAREISRMSLAFLRALFT-FQIPHR--QDRQLHVRIGMHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQAMKIHISRNTLDVLKTFGSFIITERGQIELKGKGFQTTYWLHGEGE 1106

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1)

HSP 1 Score: 338.191 bits (866), Expect = 2.082e-97
Identity = 219/571 (38.35%), Postives = 323/571 (56.57%), Query Frame = 1

Query: 1852 CMYKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQDTWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDICFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFWTAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDESCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYSSQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENATQRPTAKVIYNRFKVL--FGEKKNLVECMKEKMILYTKNLEKEVMKRTXXXXXXXXXXXXXXYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAGFCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPT-QFDEHAREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTRNPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVIEVKGKGSVNTFWLIGK 3555
             ++K   V +K +  +  I IT ++  E+K ++++S  ++ +F+G  ++H   ++V+E+C +GSL+DVL   ++  ++ +F  S   D+ RG+I+LH N     HG+LKSSNCLVDSR+ +K+TDFG+       +        MY+ S  WTAPE+L                                      N SN             PP   ++      K D+YSF +I  E+      F        + KEI  ++    ++   P+RP L L        + LI+  W E+ T RP    I    + L   G+  N+++ +  +M  Y  NLE  V KRTE+  EEK++ E+LLY MLP  VA QL +++ V AE++D V+I+FSDIVGFT L+   +P ++I LLN+LYT+FD II+N++VYKVETIGD+YMV SGLP    + H+RE+A MS+  L+ I+  F+IP     +++L+LRIG+HSGP C+GVVG + PRYCLFGDTVN +SRMESNG  LKIH S++    +     F I ERG I++KGKG   T+WL G+
Sbjct:  642 ALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLDHP--YIVYEYCPKGSLEDVLAKEQIKLDW-MFKYSLMQDICRGMIYLHNNHGP--HGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELL--------------------------------------NLSN-------------PPVNGTI------KGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKV---RNKDSPPFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISI-FIIPHR--PDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGE 1144

The following BLAST results are available for this feature:

BLAST of Guanylate cyclase vs. Ensembl Human
BLAST of Guanylate cyclase vs. Ensembl Celegans
BLAST of Guanylate cyclase vs. Ensembl Fly
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
BLAST of Guanylate cyclase vs. Ensembl Xenopus
BLAST of Guanylate cyclase vs. Ensembl Mouse
BLAST of Guanylate cyclase vs. UniProt/SwissProt
BLAST of Guanylate cyclase vs. TrEMBL
BLAST of Guanylate cyclase vs. Ensembl Cavefish
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
BLAST of Guanylate cyclase vs. Ensembl Yeast
BLAST of Guanylate cyclase vs. Ensembl Nematostella
BLAST of Guanylate cyclase vs. Ensembl Medaka
BLAST of Guanylate cyclase vs. Planmine SMEST

BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR1	6.955e-115	36.13	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
NPR2	1.050e-79	47.61	natriuretic peptide receptor 2 [Source:HGNC Symbol...	[more]
GUCY2F	9.244e-69	45.53	guanylate cyclase 2F, retinal [Source:HGNC Symbol;...	[more]
GUCY2D	1.250e-63	42.61	guanylate cyclase 2D, retinal [Source:HGNC Symbol;...	[more]
GUCY2C	4.243e-63	40.62	guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gcy-12	1.649e-129	30.38	Receptor-type guanylate cyclase gcy-12 [Source:Un...	[more]
gcy-28	7.416e-99	39.29	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	7.968e-99	39.29	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	1.207e-98	39.29	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	4.102e-94	39.34	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]

BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG10738	0.000e+0	35.01	gene:FBgn0036368 transcript:FBtr0304792	[more]
CG10738	0.000e+0	34.95	gene:FBgn0036368 transcript:FBtr0304791	[more]
CG10738	0.000e+0	34.79	gene:FBgn0036368 transcript:FBtr0302487	[more]
CG10738	0.000e+0	34.73	gene:FBgn0036368 transcript:FBtr0302488	[more]
CG42637	5.966e-139	31.39	gene:FBgn0261360 transcript:FBtr0302277	[more]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1a	2.392e-125	31.06	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1a	2.392e-125	31.06	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1b	3.685e-116	35.38	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
npr1b	4.874e-116	32.46	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
npr2	1.340e-107	36.33	natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZD...	[more]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR2	1.259e-107	38.41	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	6.163e-107	38.38	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	3.905e-106	38.22	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	1.443e-105	38.38	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	3.212e-105	38.41	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Npr1	1.951e-113	35.87	natriuretic peptide receptor 1 [Source:MGI Symbol;...	[more]
Gucy2f	1.162e-86	38.49	guanylate cyclase 2f [Source:MGI Symbol;Acc:MGI:10...	[more]
Npr2	5.318e-83	47.61	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Npr2	1.090e-79	47.61	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Gucy2g	6.282e-68	45.71	guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:10...	[more]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q7JQ32\|GC76C_DROME	5.980e-138	31.39	Receptor-type guanylate cyclase Gyc76C OS=Drosophi...	[more]
sp\|Q19187\|GCY12_CAEEL	2.098e-128	30.38	Receptor-type guanylate cyclase gcy-12 OS=Caenorha...	[more]
sp\|P16066\|ANPRA_HUMAN	3.340e-114	36.13	Atrial natriuretic peptide receptor 1 OS=Homo sapi...	[more]
sp\|P18910\|ANPRA_RAT	3.854e-114	36.00	Atrial natriuretic peptide receptor 1 OS=Rattus no...	[more]
sp\|P18293\|ANPRA_MOUSE	1.365e-112	35.87	Atrial natriuretic peptide receptor 1 OS=Mus muscu...	[more]

BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A210QCM1	0.000e+0	37.13	Guanylate cyclase OS=Mizuhopecten yessoensis OX=65...	[more]
A0A139WC82	0.000e+0	37.03	Guanylate cyclase OS=Tribolium castaneum OX=7070 G...	[more]
A0A2S2QRQ8	0.000e+0	36.11	Guanylate cyclase OS=Sipha flava OX=143950 GN=Gyc3...	[more]
A0A2H8TID5	0.000e+0	36.14	Guanylate cyclase OS=Melanaphis sacchari OX=742174...	[more]
A0A182V5M5	0.000e+0	36.00	Guanylate cyclase OS=Anopheles merus OX=30066 PE=3...	[more]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1b	4.037e-120	31.28	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1b	4.037e-120	31.28	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1b	4.598e-113	30.83	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1a	7.962e-110	41.48	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr2	5.916e-103	31.05	natriuretic peptide receptor 2 [Source:ZFIN;Acc:ZD...	[more]

BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006352.1	1.107e-111	35.05	pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 ...	[more]
ENSPMAT00000002650.1	9.472e-75	43.15	pep scaffold:Pmarinus_7.0:GL478983:4063:28109:1 ge...	[more]
NPR1	1.585e-74	43.70	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
ENSPMAT00000000043.1	9.303e-71	34.32	pep scaffold:Pmarinus_7.0:GL480785:4349:14716:1 ge...	[more]
ENSPMAT00000008976.1	1.911e-61	43.52	pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-...	[more]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
CLA4	5.422e-9	29.71	Cdc42p-activated signal transducing kinase; member...	[more]
KIC1	5.785e-9	24.56	Protein kinase of the PAK/Ste20 family, required f...	[more]
MRK1	2.752e-8	23.17	Glycogen synthase kinase 3 (GSK-3) homolog; one of...	[more]
STE11	3.745e-8	25.19	Signal transducing MEK kinase; involved in pheromo...	[more]
SPS1	4.416e-8	28.47	Putative protein serine/threonine kinase; localize...	[more]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO30985	8.962e-113	40.21	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36182	9.395e-105	35.75	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34275	6.017e-104	37.68	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27923	4.221e-98	40.21	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36203	1.673e-92	37.48	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
olgc2	1.808e-117	30.68	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
npr2	2.644e-106	41.73	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
npr2	1.299e-105	41.73	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
olgc7	5.438e-83	49.72	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
olgc7	8.384e-83	49.72	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]

BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000041839.1	0.000e+0	98.70	SMESG000041839.1	[more]
SMESG000041839.1	2.831e-127	100.00	SMESG000041839.1	[more]
SMESG000039747.1	1.385e-109	40.10	SMESG000039747.1	[more]
SMESG000039747.1	2.154e-109	40.10	SMESG000039747.1	[more]
SMESG000056411.1	2.082e-97	38.35	SMESG000056411.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019592 ID=SMED30019592|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3780bp
ATTTCGATAGATTGCGAGAGATCAGCGTAACCATAGCTAAATTAACAATG
ACCAGAAATGCTTAGCCATCGTTTAACTTATTGGAAGTCTGTTCAGATTT
TGATAATTTTCCTGGATTTATTCAAACAAACAATTCCTCTGCGGTATTCT
GAATCAGAGTTGGATGAAACTTTGAACATAAAACGCGATCGCAATCAAAC
AATAATCATAATTGGCTACGTAGCGGGGACCGAATATCCACCGGATATAG
AAATCCGCAACTATAAACGACATGGAAGACATATCTCAGGTGCTCTCACT
TACGCAGTCAACAAAATTAACAGTTGGGCACAAAATAACAGCAAGGAATC
TTTATTGCCGTCCACTTATCAAATCAGCGTTCATTTTGTTGAGACTTATG
GGGAAATGAATAACTCAATACAGGCTGTTGCCAAAATGTCTGTGGAGAAA
AAGGTTTGGGCTATAATCGGACCACAGGAAACCTGTAGAACCGAAGCGGA
TATTGCAATGGCATTTAATATCCTGATGATATCCCACTTTTGTACCGACA
ATATACTTACTGAGGATTCTCAAAGATATTCCACATTTGTCCGAACTAGA
CCACAAGTATCAGGTTTAGCAAATTATTTAGTTAGCTTTTTAAAACGCTT
CAAGTGGAATGCAGTTTCAATAATTTCGAGCGACGATAAGGAGAACGAAT
TTATTCTACAAAACTGTCTCAGTGTTTTAAAGGCCCACAATATTACAATT
CTCCACAACAAACTAGTCATGAGTCCTGCTATATACGGATCAGCCAACAA
TAAATTTAATAAAATTGTTGAAAATACATTCCAAAGTACACGAATCTACG
TTTTTATTGGATCGGACTTTGAAATATTCGGGTTACTAATGGCTTTGTAT
GAGAAGGGTCTCACAGATACAGGTAATTATTTTGTCGTATCTTTGGTGCT
ACGGCTCGAAGCGATTTCTGATTCTGCTTTTGGAAATATTCAAGTGGATT
CGCGCTCATTGCGAAATTTTGTCATCATTAGTCACATTGAACCCGAAGGT
CAGTTGATCAAAACTGAAAGCTCAAAATTCAAGTATTTCATGAGTCGACC
ACCATTCAATGTAGAATCACAAGACAAATCAAACACCTCGTACGCTCCGA
TGGAATCAAGTTACCTCTACGATGCAGTGTTGCTCTACGCCACCGTTGTT
GGAATCATTTTAAAAAATCCGAGTCTCGGCTCCCCAAAGGATGGAATGCT
TTTAAAGAAATTATTATTAAACAGATATTATAAAAGCGTTTTCGGATACA
TGAATCACATAGATAACAAAGGGGAAGCGTATGGAAATTACACGGTGAAT
CAACTGATTATCAACGCAAACGGCGAAATGAAAATAGACCCAATCGGTCT
ATTTAAACTTGACGACGGAAGTGTTCTAGAGTTCGAATTTAAGAATAATA
AAAATATAAATTGGGTTCATGATATACCGAGAGATATTCCAGAGTGTGGA
TTCAATGGAGAGATTTGTAGGACCAACGAAAAGTTCATATCTATCCCCGT
CAGTTTGTTTATTCTTTTGATATTAGTAATATTCGTGTCGGCTTTTGTCA
TAAAAAGCAAACGATATGAAAAAGAACTAGAAAGGCTTTTATGGAAGATA
GATAGACTCAAAGAGATAGATTTCTCAAATCACGAGTTGTTAGAGAAGTT
TTCTTTTATTACTAGACCACCAATTAAAGAGATTGAGAATGGAAATGTTT
GCTTACCTTTTGAAGAAGATAGTCAATTTCTCTTAGCAAAGAGCTGCTGC
AATATTGGGCATATTTTGCAACCAGATTGGGGTACGTCCAATTTGATTTT
GTGCATGTATAAAAACCAAGAAGTTGTTGTCAAAAGAGTCTATTTCAGTT
TAGCTATATCAATAACTCGCAAAGTGAAAAAAGAATTAAAGACTCTTAGA
GAAATAAGTTATGTAAATTTAAACAAATTTATGGGGGCTATAATAGAACA
TCAGGATACTTGGGTGGTTTGGGAGTTCTGTGATCGTGGCAGTCTACAAG
ATGTTTTATATAGCACAAAGCTGACCAAAGAGTATCCAGTGTTTTTGAGC
TCATTTGCTTTCGACGTTATAAGGGGTTTGATTTTTCTTCATGAAAATCC
TGATATCTGTTTTCATGGACATTTAAAGTCATCGAATTGTCTTGTTGATA
GTCGATGGACTGTTAAATTAACCGATTTTGGAATGAGAGAATTCTTAACT
TATGTGTCCCCTCAGCCTGATACTCCGGAATATATGTATTTCTTATCATT
GTTTTGGACAGCTCCGGAGATTCTTCGTGATATGATTCAACATAAATCTC
ACAATAATCAGTTTCTTCAAAGTTTGAAGCTTGGACTGATACAAGAAAGG
AAGAGGTCACACGAAAATAAAACAGACGTAAATGCTTCTAATTTCTCAAA
TGATGAATCGTGTTTAGAAGCATTTATTAAAATAAAGTTTCCCCCGAATC
CAAACAGCCTAGATTCTATTTCTTTTCAAAAATCAGACATTTATTCATTT
GGAATGATATTTTATGAATTACACAGCTGCCAGATTCCGTTTTTGTCAAA
TTACTCTTCTCAGAATTCTCCTAAAGAAATTATCAGACGACTAATTGTTT
TAAATGATCAATTTAAAGTTCCATACAGACCAAAATTAAGCTTGCTCAGT
AGAACAGATAAAAAACAAATAGATTTAATTAAATTATGCTGGCAGGAAAA
TGCCACTCAAAGACCAACAGCCAAAGTAATTTATAATAGATTTAAAGTTC
TATTTGGAGAAAAGAAAAATCTCGTTGAATGTATGAAAGAAAAAATGATA
CTTTATACGAAAAACTTAGAAAAAGAAGTCATGAAAAGAACGGAAGAGCT
TCGAGAGGAAAAGAAGCAAAATGAAGAACTTTTATATCAGATGTTACCTA
TTCCTGTAGCCGAGCAACTCAGACAACATAAACAAGTAGAAGCTGAAGCT
TTTGATAGCGTATCTATATATTTTAGCGATATTGTTGGATTTACAGAACT
TGCAGGGTTTTGCAGTCCATTCGAAGTTATAAATTTATTAAATCAGTTAT
ATACATCATTTGATAAAATAATTGACAATTTCAATGTCTATAAAGTGGAA
ACAATCGGGGACTCCTATATGGTCGTCAGTGGACTTCCCACACAATTTGA
TGAACATGCTAGAGAAATGGCCAACATGTCTTTGAGACTATTGGAAGAAA
TTACCAAGGGATTTGTAATTCCCTCGGAAAAATACAAAAACGAACGTTTA
AAACTCAGAATTGGCCTTCACTCAGGGCCTTGCTGTGCTGGTGTTGTGGG
AACCAGAAATCCTCGCTATTGTTTATTTGGAGACACTGTAAATATGGCTA
GTAGAATGGAGAGTAATGGCGAAGCTTTGAAAATTCATTGTTCTGAAGCC
TTTATTTTGCAGATTTTGTATTTAAATGAATTTCATATTGTTGAAAGAGG
GGTTATAGAGGTCAAAGGTAAGGGTTCAGTAAATACATTTTGGCTAATTG
GAAAGTTAGAACAAAATATTTCAAACATCGATAGTATAAAATTTGTTCAT
TCTCACTCATACAAATCCAATTCGGAAATTTCTTCAGATGGGCTGATGTT
AGAAAAATCGTTCAAAGGTAAATCAAAAAATAATTTTTTCGAAAAAATGA
AAGAAAACACTTACAAAACCAAATTCCAAAAACGGGATTTGATAAAATAA
AATAAAAACAAAATTCAGATTAAATCAATC

protein sequence of SMED30019592-orf-1

>SMED30019592-orf-1 ID=SMED30019592-orf-1|Name=SMED30019592-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1231bp
MLSHRLTYWKSVQILIIFLDLFKQTIPLRYSESELDETLNIKRDRNQTII
IIGYVAGTEYPPDIEIRNYKRHGRHISGALTYAVNKINSWAQNNSKESLL
PSTYQISVHFVETYGEMNNSIQAVAKMSVEKKVWAIIGPQETCRTEADIA
MAFNILMISHFCTDNILTEDSQRYSTFVRTRPQVSGLANYLVSFLKRFKW
NAVSIISSDDKENEFILQNCLSVLKAHNITILHNKLVMSPAIYGSANNKF
NKIVENTFQSTRIYVFIGSDFEIFGLLMALYEKGLTDTGNYFVVSLVLRL
EAISDSAFGNIQVDSRSLRNFVIISHIEPEGQLIKTESSKFKYFMSRPPF
NVESQDKSNTSYAPMESSYLYDAVLLYATVVGIILKNPSLGSPKDGMLLK
KLLLNRYYKSVFGYMNHIDNKGEAYGNYTVNQLIINANGEMKIDPIGLFK
LDDGSVLEFEFKNNKNINWVHDIPRDIPECGFNGEICRTNEKFISIPVSL
FILLILVIFVSAFVIKSKRYEKELERLLWKIDRLKEIDFSNHELLEKFSF
ITRPPIKEIENGNVCLPFEEDSQFLLAKSCCNIGHILQPDWGTSNLILCM
YKNQEVVVKRVYFSLAISITRKVKKELKTLREISYVNLNKFMGAIIEHQD
TWVVWEFCDRGSLQDVLYSTKLTKEYPVFLSSFAFDVIRGLIFLHENPDI
CFHGHLKSSNCLVDSRWTVKLTDFGMREFLTYVSPQPDTPEYMYFLSLFW
TAPEILRDMIQHKSHNNQFLQSLKLGLIQERKRSHENKTDVNASNFSNDE
SCLEAFIKIKFPPNPNSLDSISFQKSDIYSFGMIFYELHSCQIPFLSNYS
SQNSPKEIIRRLIVLNDQFKVPYRPKLSLLSRTDKKQIDLIKLCWQENAT
QRPTAKVIYNRFKVLFGEKKNLVECMKEKMILYTKNLEKEVMKRTEELRE
EKKQNEELLYQMLPIPVAEQLRQHKQVEAEAFDSVSIYFSDIVGFTELAG
FCSPFEVINLLNQLYTSFDKIIDNFNVYKVETIGDSYMVVSGLPTQFDEH
AREMANMSLRLLEEITKGFVIPSEKYKNERLKLRIGLHSGPCCAGVVGTR
NPRYCLFGDTVNMASRMESNGEALKIHCSEAFILQILYLNEFHIVERGVI
EVKGKGSVNTFWLIGKLEQNISNIDSIKFVHSHSYKSNSEISSDGLMLEK
SFKGKSKNNFFEKMKENTYKTKFQKRDLIK*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000099	neuron
PLANA:0000418	head

Vocabulary: **INTERPRO**
Term	Definition
IPR001054	A/G_cyclase
IPR000719	Prot_kinase_dom
IPR011645	HNOB_dom_associated
IPR001828	ANF_lig-bd_rcpt
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR018297	A/G_cyclase_CS
IPR028082	Peripla_BP_I
IPR029787	Nucleotide_cyclase
IPR011009	Kinase-like_dom_sf
IPR000651	Ras-like_Gua-exchang_fac_N

Vocabulary: **biological process**
Term	Definition
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0006468	protein phosphorylation
GO:0006182	cGMP biosynthetic process

Vocabulary: **molecular function**
Term	Definition
GO:0016849	phosphorus-oxygen lyase activity
GO:0005524	ATP binding
GO:0004672	protein kinase activity
GO:0004383	guanylate cyclase activity
GO:0000166	nucleotide binding
GO:0016829	lyase activity

Vocabulary: **cellular component**
Term	Definition
GO:0005622	intracellular
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 517..537
None	No IPR available	COILS	Coil	Coil	coord: 934..958
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 814..955 e-value: 2.8E-14 score: 54.6 coord: 592..766 e-value: 6.4E-30 score: 106.0
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 76..428 e-value: 4.2E-56 score: 192.7
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 186..482 e-value: 4.2E-56 score: 192.7
None	No IPR available	PANTHER	PTHR11920	ADENYLATE AND GUANYLATE CYCLASES	coord: 44..758
None	No IPR available	PANTHER	PTHR11920	ADENYLATE AND GUANYLATE CYCLASES	coord: 822..1168
None	No IPR available	PANTHER	PTHR11920:SF475	GUANYLATE CYCLASE	coord: 822..1168
None	No IPR available	PANTHER	PTHR11920:SF475	GUANYLATE CYCLASE	coord: 44..758
None	No IPR available	CDD	cd07302	CHD	coord: 985..1163 e-value: 1.02498E-60 score: 203.58
None	No IPR available	TMHMM	TMhelix		coord: 493..515
None	No IPR available	TMHMM	TMhelix		coord: 369..391
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	SMART	SM00044	cyc_6	coord: 950..1154 e-value: 7.1E-90 score: 314.6
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PFAM	PF00211	Guanylate_cyc	coord: 978..1164 e-value: 2.7E-61 score: 206.4
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PROSITE	PS50125	GUANYLATE_CYCLASE_2	coord: 986..1118 score: 47.919
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 822..910 e-value: 1.2E-5 score: 24.7 coord: 602..760 e-value: 8.0E-22 score: 77.8
IPR001828	Receptor, ligand binding region	PFAM	PF01094	ANF_receptor	coord: 79..433 e-value: 2.6E-32 score: 112.3
IPR029787	Nucleotide cyclase	GENE3D	G3DSA:3.30.70.1230		coord: 973..1167 e-value: 3.1E-69 score: 234.3
IPR029787	Nucleotide cyclase	SUPERFAMILY	SSF55073	Nucleotide cyclase	coord: 972..1164
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	PROSITE	PS00452	GUANYLATE_CYCLASE_1	coord: 1095..1118
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 550..916 score: 23.34
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 598..910
IPR028082	Periplasmic binding protein-like I	SUPERFAMILY	SSF53822	Periplasmic binding protein-like I	coord: 70..482