Protein lifeguard 2

Overview


Name	Protein lifeguard 2
Smed ID	SMED30019535
Length (bp)	1238

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Protein lifeguard 2 (SMED30019535) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein lifeguard 2 (SMED30019535) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein lifeguard 2 (SMED30019535) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein lifeguard 2 (SMED30019535) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019535

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 7

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
protonephridia	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchymal cell	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30019535	SMESG000057144.1	dd_Smed_v4_1586_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of Protein lifeguard 2 vs. Ensembl Human
Match: TMBIM1 (transmembrane BAX inhibitor motif containing 1 [Source:HGNC Symbol;Acc:HGNC:23410])

HSP 1 Score: 213.772 bits (543), Expect = 8.040e-66
Identity = 118/248 (47.58%), Postives = 168/248 (67.74%), Query Frame = 2

Query:  296 GAGDMYGGDNFAA--------FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G G  Y G+  A         + D+ VR+ FIRKVY I++ QLL+T   IA+F FVEP+  +V+RN   YY+S+A+F+VTY+ L CC G RR++P N   L++FT A+ +MT TI+S Y+T AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VLL+T    GI+ + +   + V   H +YA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DI+ +F  +L L G++N
Sbjct:   68 GPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVT----GIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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Query:  296 GAGDMYGGDNFAA--------FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G G  Y G+  A         + D+ VR+ FIRKVY I++ QLL+T   IA+F FVEP+  +V+RN   YY+S+A+F+VTY+ L CC G RR++P N   L++FT A+ +MT TI+S Y+T AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VLL+T    GI+ + +   + V   H +YA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DI+ +F  +L L G++N
Sbjct:   68 GPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVT----GIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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Query:  296 GAGDMYGGDNFAA--------FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G G  Y G+  A         + D+ VR+ FIRKVY I++ QLL+T   IA+F FVEP+  +V+RN   YY+S+A+F+VTY+ L CC G RR++P N   L++FT A+ +MT TI+S Y+T AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VLL+T    GI+ + +   + V   H +YA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DI+ +F  +L L G++N
Sbjct:   68 GPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVT----GIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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BLAST of Protein lifeguard 2 vs. Ensembl Human
Match: FAIM2 (Fas apoptotic inhibitory molecule 2 [Source:HGNC Symbol;Acc:HGNC:17067])

HSP 1 Score: 206.453 bits (524), Expect = 1.823e-63
Identity = 114/268 (42.54%), Postives = 167/268 (62.31%), Query Frame = 2

Query:  236 YPPQPQVY----NYQATEPQPPYQGAGDMYGGDN--FAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +PP P       ++   +P            GD+  F  FS  D+ VR  F+RKVY I+  QLLVT   +A+F F +P++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L++FTL+++Y+T  ++S+Y T +VL+  GITA+VC+S+T+F+ QTK DFT C G++     VLL+T    G+I A + P + V   HAVYA L   VF ++L  DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:    6 FPPAPTAVPLHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVL----FVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 269

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BLAST of Protein lifeguard 2 vs. Ensembl Human
Match: FAIM2 (Fas apoptotic inhibitory molecule 2 [Source:HGNC Symbol;Acc:HGNC:17067])

HSP 1 Score: 206.068 bits (523), Expect = 1.101e-62
Identity = 110/237 (46.41%), Postives = 159/237 (67.09%), Query Frame = 2

Query:  317 GDN--FAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            GD+  F  FS  D+ VR  F+RKVY I+  QLLVT   +A+F F +P++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L++FTL+++Y+T  ++S+Y T +VL+  GITA+VC+S+T+F+ QTK DFT C G++     VLL+T    G+I A + P + V   HAVYA L   VF ++L  DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   83 GDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVL----FVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 315

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BLAST of Protein lifeguard 2 vs. Ensembl Celegans
Match: tag-120 (pep chromosome:WBcel235:V:9706603:9709814:-1 gene:WBGene00006470.1 transcript:F40F9.2.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-120)

HSP 1 Score: 171.014 bits (432), Expect = 1.336e-50
Identity = 93/246 (37.80%), Postives = 148/246 (60.16%), Query Frame = 2

Query:  263 YQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            Y AT  Q    G  +++       FS ++VR  F+RKV++++T    +T  F  +    EP Q WVK N W Y+++  +F+V  IAL CC  +RR++P N   L+IFTL+ + MT  + + Y   +VL+   IT +   S+ IF+M+TK D T   G I  +  ++L +     +I+      + +++VY+GL  L+   YL  D QL++GGRKYELSPEDYI  A++++LDI+N+FL++L++FG 
Sbjct:    5 YGATTAQDDPDGKYNLH-------FSSQTVRAAFVRKVFMLVTIMFAITAAFCVIPMVSEPFQDWVKNNFWVYFIAIIVFLVVAIALSCCGNLRRQFPVNIILLTIFTLSAAVMTMFVTACYNVQSVLICLCITTVCSGSVIIFSMKTKSDLTSKMG-IAFMLSMVLFSFGIFALIFTLAFNWQFLYSVYSGLAALLMMFYLAIDVQLLMGGRKYELSPEDYIFAAMEIFLDILNIFLMLLNIFGR 242

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BLAST of Protein lifeguard 2 vs. Ensembl Celegans
Match: tag-120 (pep chromosome:WBcel235:V:9707771:9709877:-1 gene:WBGene00006470.1 transcript:F40F9.2.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-120)

HSP 1 Score: 171.014 bits (432), Expect = 1.336e-50
Identity = 93/246 (37.80%), Postives = 148/246 (60.16%), Query Frame = 2

Query:  263 YQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            Y AT  Q    G  +++       FS ++VR  F+RKV++++T    +T  F  +    EP Q WVK N W Y+++  +F+V  IAL CC  +RR++P N   L+IFTL+ + MT  + + Y   +VL+   IT +   S+ IF+M+TK D T   G I  +  ++L +     +I+      + +++VY+GL  L+   YL  D QL++GGRKYELSPEDYI  A++++LDI+N+FL++L++FG 
Sbjct:    5 YGATTAQDDPDGKYNLH-------FSSQTVRAAFVRKVFMLVTIMFAITAAFCVIPMVSEPFQDWVKNNFWVYFIAIIVFLVVAIALSCCGNLRRQFPVNIILLTIFTLSAAVMTMFVTACYNVQSVLICLCITTVCSGSVIIFSMKTKSDLTSKMG-IAFMLSMVLFSFGIFALIFTLAFNWQFLYSVYSGLAALLMMFYLAIDVQLLMGGRKYELSPEDYIFAAMEIFLDILNIFLMLLNIFGR 242

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BLAST of Protein lifeguard 2 vs. Ensembl Celegans
Match: xbx-6 (X-BoX promoter element regulated [Source:UniProtKB/TrEMBL;Acc:Q8MQ56])

HSP 1 Score: 160.614 bits (405), Expect = 4.861e-46
Identity = 95/260 (36.54%), Postives = 142/260 (54.62%), Query Frame = 2

Query:  236 YPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSG---MIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + P P ++     + +    G GD   G     FSDK+VR  F+RKV+ ++   L +      +    +   + V+RN   Y  S+ IF VTY++LVCC GVRRK+P N     IFTLA S MT  I++ ++   VL+A  I      SI I A QTK D T   G   +I +  +   L  + C + +      K +  VYA    L+  +YL  D Q+++GG+KYE+SPE+YI  ++Q+++DIV MF  +LSLFG++N
Sbjct:   41 FSPPPPMHGAMFNQMENGQHGGGDNPDGKYSFQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKI----KFLMMVYALGGALIMMLYLFLDVQMLMGGKKYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSRN 296

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Query:  236 YPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSG---MIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + P P ++     + +    G GD   G     FSDK+VR  F+RKV+ ++   L +      +    +   + V+RN   Y  S+ IF VTY++LVCC GVRRK+P N     IFTLA S MT  I++ ++   VL+A  I      SI I A QTK D T   G   +I +  +   L  + C + +      K +  VYA    L+  +YL  D Q+++GG+KYE+SPE+YI  ++Q+++DIV MF  +LSLFG++N
Sbjct:   41 FSPPPPMHGAMFNQMENGQHGGGDNPDGKYSFQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKI----KFLMMVYALGGALIMMLYLFLDVQMLMGGKKYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSRN 296

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Query:  236 YPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSG---MIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + P P ++     + +    G GD   G     FSDK+VR  F+RKV+ ++   L +      +    +   + V+RN   Y  S+ IF VTY++LVCC GVRRK+P N     IFTLA S MT  I++ ++   VL+A  I      SI I A QTK D T   G   +I +  +   L  + C + +      K +  VYA    L+  +YL  D Q+++GG+KYE+SPE+YI  ++Q+++DIV MF  +LSLFG++N
Sbjct:   41 FSPPPPMHGAMFNQMENGQHGGGDNPDGKYSFQFSDKTVRAAFVRKVFSLVFIMLCIVAAVTVIPWVHDDTMRMVRRNSALYLGSYVIFFVTYLSLVCCEGVRRKFPVNLIVTGIFTLATSVMTMVISAHHDANVVLLALAICIGCTFSIVIVASQTKFDLTAHMGYILIISMCFMFFGLVVVICSMFFKI----KFLMMVYALGGALIMMLYLFLDVQMLMGGKKYEISPEEYIFASVQIFIDIVQMFWFLLSLFGSRN 296

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BLAST of Protein lifeguard 2 vs. Ensembl Fly
Match: Lfg (gene:FBgn0025692 transcript:FBtr0087813)

HSP 1 Score: 211.846 bits (538), Expect = 3.363e-66
Identity = 114/249 (45.78%), Postives = 164/249 (65.86%), Query Frame = 2

Query:  254 VYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            +Y+YQ  +    Y  A      D   AF D+S+R GFIRKVYLI+  QLL+T  F++VF F +  Q+WV++NP  ++++ A+ IVT I + CC  VRRK P NF  L +FT+A S++   +A  +E   VL+A GITA V + +T+FA+QTK DFTMC G+++   +V ++ G+      A   P KV+  VYA L  L+F +YL+YDTQL++GG  KY +SPE+YI  AL LYLDI+N+F+ IL++ G
Sbjct:    1 MYHYQQGDETGAYTDAE----ADKSFAFDDQSIRKGFIRKVYLILMCQLLITFGFVSVFTFSKASQEWVQKNPALFWIALAVLIVTMICMACCESVRRKTPLNFIFLFLFTVAESFLLGMVAGQFEADEVLMAVGITAAVALGLTLFALQTKYDFTMCGGVLVACLVVFIIFGII-----AIFIPGKVIGLVYASLGALLFSVYLVYDTQLMLGGNHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 240

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BLAST of Protein lifeguard 2 vs. Ensembl Fly
Match: Lfg (gene:FBgn0025692 transcript:FBtr0332885)

HSP 1 Score: 207.608 bits (527), Expect = 1.307e-64
Identity = 109/228 (47.81%), Postives = 156/228 (68.42%), Query Frame = 2

Query:  317 GDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
             D   AF D+S+R GFIRKVYLI+  QLL+T  F++VF F +  Q+WV++NP  ++++ A+ IVT I + CC  VRRK P NF  L +FT+A S++   +A  +E   VL+A GITA V + +T+FA+QTK DFTMC G+++   +V ++ G+      A   P KV+  VYA L  L+F +YL+YDTQL++GG  KY +SPE+YI  AL LYLDI+N+F+ IL++ G
Sbjct:   13 ADKSFAFDDQSIRKGFIRKVYLILMCQLLITFGFVSVFTFSKASQEWVQKNPALFWIALAVLIVTMICMACCESVRRKTPLNFIFLFLFTVAESFLLGMVAGQFEADEVLMAVGITAAVALGLTLFALQTKYDFTMCGGVLVACLVVFIIFGII-----AIFIPGKVIGLVYASLGALLFSVYLVYDTQLMLGGNHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 235

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BLAST of Protein lifeguard 2 vs. Ensembl Fly
Match: Lfg (gene:FBgn0025692 transcript:FBtr0087814)

HSP 1 Score: 207.608 bits (527), Expect = 1.307e-64
Identity = 109/228 (47.81%), Postives = 156/228 (68.42%), Query Frame = 2

Query:  317 GDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
             D   AF D+S+R GFIRKVYLI+  QLL+T  F++VF F +  Q+WV++NP  ++++ A+ IVT I + CC  VRRK P NF  L +FT+A S++   +A  +E   VL+A GITA V + +T+FA+QTK DFTMC G+++   +V ++ G+      A   P KV+  VYA L  L+F +YL+YDTQL++GG  KY +SPE+YI  AL LYLDI+N+F+ IL++ G
Sbjct:   13 ADKSFAFDDQSIRKGFIRKVYLILMCQLLITFGFVSVFTFSKASQEWVQKNPALFWIALAVLIVTMICMACCESVRRKTPLNFIFLFLFTVAESFLLGMVAGQFEADEVLMAVGITAAVALGLTLFALQTKYDFTMCGGVLVACLVVFIIFGII-----AIFIPGKVIGLVYASLGALLFSVYLVYDTQLMLGGNHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 235

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BLAST of Protein lifeguard 2 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0332883)

HSP 1 Score: 191.43 bits (485), Expect = 1.800e-57
Identity = 106/261 (40.61%), Postives = 157/261 (60.15%), Query Frame = 2

Query:  239 PPQPQVYN-YQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMG------PSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            PP    Y  Y   E QP            NF+ F D+S+R GFIRKVYLI+  QL+VT   +A+F + E  + + + N W ++++  + +VT +++ CC  VRR+ P NF  L +FT A S++    A+ Y    VL+A GITA VC+++TIFA+QTK DFTM  G++           ++C +++   G        K++  VYA +  L+F +YLIYDTQL++GG  KY +SPE+YI  AL LYLDI+N+F+ IL++ G
Sbjct:   75 PPSAGGYGAYDDPESQP-----------KNFS-FDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGIL-----------IACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 312

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BLAST of Protein lifeguard 2 vs. Ensembl Fly
Match: Nmda1 (gene:FBgn0013305 transcript:FBtr0089878)

HSP 1 Score: 191.43 bits (485), Expect = 1.800e-57
Identity = 106/261 (40.61%), Postives = 157/261 (60.15%), Query Frame = 2

Query:  239 PPQPQVYN-YQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMG------PSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            PP    Y  Y   E QP            NF+ F D+S+R GFIRKVYLI+  QL+VT   +A+F + E  + + + N W ++++  + +VT +++ CC  VRR+ P NF  L +FT A S++    A+ Y    VL+A GITA VC+++TIFA+QTK DFTM  G++           ++C +++   G        K++  VYA +  L+F +YLIYDTQL++GG  KY +SPE+YI  AL LYLDI+N+F+ IL++ G
Sbjct:   75 PPSAGGYGAYDDPESQP-----------KNFS-FDDQSIRRGFIRKVYLILMGQLIVTFGAVALFVYHEGTKTFARNNMWLFWVALGVMLVTMLSMACCESVRRQTPTNFIFLGLFTAAQSFLMGVSATKYAPKEVLMAVGITAAVCLALTIFALQTKYDFTMMGGIL-----------IACMVVFLIFGIVAIFVKGKIITLVYASIGALLFSVYLIYDTQLMMGGEHKYSISPEEYIFAALNLYLDIINIFMYILTIIG 312

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BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
Match: grinaa (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-060616-231])

HSP 1 Score: 205.297 bits (521), Expect = 3.983e-62
Identity = 125/280 (44.64%), Postives = 174/280 (62.14%), Query Frame = 2

Query:  242 PQPQVYNYQATEPQPPYQ-------------------------GAGDMYGGDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            P PQ    Q   PQ PYQ                         G    YG D+FA   + DKS+R  FIRKV++++T QLLVT  F+ VF F + ++ +V+RN W YY+S+AIF V+ I L CC  VRRK+P N  ALSI TL+LSY+   IASFY+T AV++A GIT +VC ++ +F++QTK DFT C G++LV ++VLL+  + C  I      +K++H VYA L  L+F  +L  DTQL++G +K  +SPE+Y+  AL LY DI+N+FL IL++ G 
Sbjct:   86 PYPQANYAQGPYPQSPYQQGPGQPAFGVDPNASMESPGYHGGDGPPSYYGNDDFANSNWEDKSIRRAFIRKVFMVLTVQLLVTFSFVTVFTFAKDVKVFVRRNQWTYYVSYAIFFVSLIVLSCCGEVRRKHPWNLVALSILTLSLSYLVGMIASFYDTDAVIMAVGITVVVCFAVVVFSLQTKYDFTSCYGVLLVCTIVLLVACILCIFIR-----NKILHIVYASLGALLFTCFLAVDTQLLLGNKKLAISPEEYVFAALNLYTDIINIFLYILAIVGR 360

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BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1a [Source:ZFIN;Acc:ZDB-GENE-041010-69])

HSP 1 Score: 197.208 bits (500), Expect = 2.659e-59
Identity = 114/237 (48.10%), Postives = 155/237 (65.40%), Query Frame = 2

Query:  296 GAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            G GD  G      F    VR+ FIRKVYLI+ AQLLVT   +A+F FVEP+  +V++NP  Y++S+AI+ VT+I LVCC G RR++P N   L+IFTLALS+MT  IAS+Y T AV +A  IT +VC+++T+F  QTK+DFT CSG       VL +     GII A +   K V   H +YA +  + F ++L Y TQL+IG RK  +SPE+Y+  AL LY+DIV +F+ +L + G
Sbjct:   96 GIGDSEGFTTAEGFESTDVRHSFIRKVYLILAAQLLVTAAVVAIFTFVEPVGLFVRKNPAIYWVSYAIYFVTHIVLVCCQGPRRRFPWNLLLLAIFTLALSFMTGNIASYYSTRAVFLALAITVVVCVAVTVFCFQTKVDFTKCSGFF----CVLGIVVFVTGIITAIVLSFKYVPWLHMLYASIGAIAFTLFLAYHTQLLIGNRKLSISPEEYVFAALSLYVDIVQIFIFLLQIIG 328

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BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 193.741 bits (491), Expect = 2.596e-58
Identity = 100/226 (44.25%), Postives = 154/226 (68.14%), Query Frame = 2

Query:  329 AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + + DK++R  FIRKV+ I+  QL+VT   +++F F EP++K+V+ N  FY  S+  F+ TY+ LVC    RR+YP N   L+IFTLA+SYM   +AS++ T  V+++ GITA+VC++IT+F  Q+++DFT C G++  L +VL++TGL      A  G    +H  YAG   LVF ++L +D QL+IG R+Y L+PE+++ GA+ LY+D+V +FL  L LFG++ 
Sbjct:   82 SNWEDKNIRRMFIRKVFCILMVQLMVTFSVVSLFTFCEPVRKFVQYNRVFYLTSYMTFMGTYLMLVCSTNARRRYPTNMILLAIFTLAMSYMAGMLASYHNTKVVMLSVGITALVCLAITLFCFQSRVDFTTCHGLLFSLMMVLMITGLLL-FFTAPFGYIPWLHTAYAGFGALVFTLFLAFDMQLLIGNRRYSLNPEEHVFGAICLYMDVVYIFLFFLQLFGSRE 306

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Query:  329 AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + + DK++R  FIRKV+ I+  QL+VT   +++F F EP++K+V+ N  FY  S+  F+ TY+ LVC    RR+YP N   L+IFTLA+SYM   +AS++ T  V+++ GITA+VC++IT+F  Q+++DFT C G++  L +VL++TGL      A  G    +H  YAG   LVF ++L +D QL+IG R+Y L+PE+++ GA+ LY+D+V +FL  L LFG++ 
Sbjct:   82 SNWEDKNIRRMFIRKVFCILMVQLMVTFSVVSLFTFCEPVRKFVQYNRVFYLTSYMTFMGTYLMLVCSTNARRRYPTNMILLAIFTLAMSYMAGMLASYHNTKVVMLSVGITALVCLAITLFCFQSRVDFTTCHGLLFSLMMVLMITGLLL-FFTAPFGYIPWLHTAYAGFGALVFTLFLAFDMQLLIGNRRYSLNPEEHVFGAICLYMDVVYIFLFFLQLFGSRE 306

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BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
Match: grinab (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1b (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-040426-1367])

HSP 1 Score: 187.193 bits (474), Expect = 2.136e-55
Identity = 98/234 (41.88%), Postives = 150/234 (64.10%), Query Frame = 2

Query:  311 YGGDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            Y  D F++    +K +R  FIRKV+ +++ QL +T  F+A+F F   ++ +V +N W Y++ + +F+V Y  ++CC   RRK+P N   LS+ TLA+SYM   I+SFY+T  V++A GIT +VC ++ IF+MQTK DFT C G++ V  +VL + G+ C I Y     SK++  +Y+ L  L+F  +L  DTQL++G +   LSPE+YI  +L LYLDI+ +FL IL + G   
Sbjct:  108 YDSDQFSSSGLDNKEIRRVFIRKVFSVLSLQLAITTAFVAIFTFEPHVKLFVMQNSWTYWVGYLVFLVPYFVILCCGEFRRKHPWNLICLSVLTLAMSYMVGVISSFYDTDIVIMAIGITVVVCFTVIIFSMQTKYDFTSCYGVLFVCGIVLFVFGILCIIFY-----SKIMDLIYSTLGALLFTCFLAVDTQLLLGNKNLSLSPEEYIFASLNLYLDIIQIFLFILRILGRSR 336

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BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Match: tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:595060])

HSP 1 Score: 223.402 bits (568), Expect = 5.469e-69
Identity = 119/249 (47.79%), Postives = 168/249 (67.47%), Query Frame = 2

Query:  284 PPYQGAGDMYG-----GDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P   G G+MY      G NF ++ DK+VR+ FIR+VY I+  QLL+T   IA+F +VEP+  +++R P  YY S+A+F VTYI LVCC G RR++P N   L+IFTLA+++M  TIASFY + AVL++ GITAIV I +TIF  QTK+DFT C+G+      VL +     GI+ A +   K V   H +YA L  +VF ++L +DTQLVIG RK+ ++PE+Y+ GAL++Y DIV +FL +L + G++ 
Sbjct:  109 PLNTGDGEMYNTNDGEGGNFGSWDDKAVRHAFIRRVYAIIAVQLLLTVGIIAIFTYVEPVTSFIRRTPGVYYASYAVFFVTYIVLVCCEGPRRRFPWNIILLAIFTLAMAFMAGTIASFYSSKAVLISMGITAIVTIIVTIFCFQTKVDFTSCAGLF----AVLGIVMFVTGIVTAIVLAFKYVYWLHMLYAALGAIVFTLFLAFDTQLVIGNRKHTINPEEYVYGALKIYTDIVYIFLNLLQIIGSRT 353

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BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Match: faim2 (Fas apoptotic inhibitory molecule 2 [Source:NCBI gene;Acc:779810])

HSP 1 Score: 213.386 bits (542), Expect = 1.005e-65
Identity = 121/312 (38.78%), Postives = 186/312 (59.62%), Query Frame = 2

Query:   92 NCMASAPPSYDDVTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTVYPPQPQVYNYQATEPQPPYQGAGDMYGGDN----FAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            N  +SAPPSY++ T                                    P    +++Q  EP      +  +Y GD       ++ +++VR GFIRKVY I+  QLLVT   +A+F F +P++ +++ NP +Y+ S+A+F  TY+ L CC G RRK+P N   L IFTL+++Y+T  ++SFY T +V++  GITA+VC+S+T+F+ Q+KIDFT C G++ VLS+VLL +    GI    + P + +   HAVYA +  +VF ++L +DTQ+++G R+Y LSPE+YI GAL +YLDI+ +F  +L LFG + 
Sbjct:   26 NNRSSAPPSYEEATAGDGKKADYLQAT----------------------SPTLSQHSWQHGEPYNSPDCSSGIYSGDTEMLTTQSWDNETVRRGFIRKVYAILMIQLLVTVAVVALFTFCDPVKGYIQANPGWYWASYAVFFSTYLVLACCSGPRRKFPWNLILLCIFTLSMAYITGMLSSFYNTKSVILCLGITALVCMSVTLFSFQSKIDFTSCQGVLFVLSMVLLFS----GIFLVILIPFQYIPWLHAVYAVIGAIVFTMFLAFDTQMLMGSRRYSLSPEEYIFGALNIYLDIIYIFSFLLQLFGTQE 311

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BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Match: tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:595060])

HSP 1 Score: 202.601 bits (514), Expect = 3.493e-61
Identity = 112/245 (45.71%), Postives = 159/245 (64.90%), Query Frame = 2

Query:  296 GAGDMYG-----GDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G G+MY      G NF ++ DK+VR+ FIR+VY I+  QLL+T   IA+F +VEP+  +++R P  YY S+A+F VTYI LVCC G RR++P N   L+IF +  S       SFY + AVL++ GITAIV I +TIF  QTK+DFT C+G+      VL +     GI+ A +   K V   H +YA L  +VF ++L +DTQLVIG RK+ ++PE+Y+ GAL++Y DIV +FL +L + G++ 
Sbjct:   95 GDGEMYNTNDGEGGNFGSWDDKAVRHAFIRRVYAIIAVQLLLTVGIIAIFTYVEPVTSFIRRTPGVYYASYAVFFVTYIVLVCCEGPRRRFPWNIILLAIFYVVFSLY----CSFYSSKAVLISMGITAIVTIIVTIFCFQTKVDFTSCAGLF----AVLGIVMFVTGIVTAIVLAFKYVYWLHMLYAALGAIVFTLFLAFDTQLVIGNRKHTINPEEYVYGALKIYTDIVYIFLNLLQIIGSRT 331

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BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Match: tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:595060])

HSP 1 Score: 190.274 bits (482), Expect = 2.638e-56
Identity = 109/249 (43.78%), Postives = 157/249 (63.05%), Query Frame = 2

Query:  284 PPYQGAGDMYG-----GDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P   G G+MY      G NF ++ DK+VR+ FIR+VY I+  QLL+T   IA+F +VEP+  +++R P  YY S+A+F VTYI LVCC G R  +   F+   +F+       A + SFY + AVL++ GITAIV I +TIF  QTK+DFT C+G+      VL +     GI+ A +   K V   H +YA L  +VF ++L +DTQLVIG RK+ ++PE+Y+ GAL++Y DIV +FL +L + G++ 
Sbjct:  109 PLNTGDGEMYNTNDGEGGNFGSWDDKAVRHAFIRRVYAIIAVQLLLTVGIIAIFTYVEPVTSFIRRTPGVYYASYAVFFVTYIVLVCCEGPRSVHFNIFYICFVFS-----ELAFVISFYSSKAVLISMGITAIVTIIVTIFCFQTKVDFTSCAGLF----AVLGIVMFVTGIVTAIVLAFKYVYWLHMLYAALGAIVFTLFLAFDTQLVIGNRKHTINPEEYVYGALKIYTDIVYIFLNLLQIIGSRT 348

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BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Match: grina (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:NCBI gene;Acc:100145094])

HSP 1 Score: 171.014 bits (432), Expect = 2.555e-49
Identity = 98/224 (43.75%), Postives = 142/224 (63.39%), Query Frame = 2

Query:  329 AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGR-KYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            + FS+ ++R  FIRKVYL +  QL +T   I +F F + ++ WV+  P+  Y      I+  + L CC  VRRK P NF  L +FT     M  TIA+ ++  AV+ A G T +V + +TIFA+QTK DFTM SG + V  LVLL  G+ CGI+      S  ++ VYA +   +FG+YL+ DTQL++GG+ +Y +SPE+YI  AL +YLDI+N+FL++L +FG
Sbjct:   89 SPFSESAIRRAFIRKVYLTLAMQLALTVGLICMFIFWKRLKNWVQEYPYIVYALCPAIIILALVLACCQQVRRKVPYNFIFLGLFTAVEGCMLGTIAALFDADAVMWAGGATIVVTLGLTIFALQTKWDFTMLSGGLCVALLVLLCFGILCGILR-----SMYLNIVYASIGTFIFGMYLVVDTQLIVGGKHRYAVSPEEYIFAALNIYLDIINLFLMLLQIFG 307

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BLAST of Protein lifeguard 2 vs. Ensembl Mouse
Match: Tmbim1 (transmembrane BAX inhibitor motif containing 1 [Source:MGI Symbol;Acc:MGI:1916910])

HSP 1 Score: 216.853 bits (551), Expect = 3.343e-67
Identity = 118/236 (50.00%), Postives = 167/236 (70.76%), Query Frame = 2

Query:  314 GGDNF--AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G D+F    + D+ VR+ FI+KVY I++ QLL+T   IA+F FVEP+ K+V+ N   YY+S+A+F+VTY+ L CC G RR++P N   L+IFTLAL ++T TI+S YET AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VL++T    GI+ + +   K +   H VYA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DIV +F  +L L G+++
Sbjct:   78 GSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVT----GIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

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Query:  314 GGDNF--AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G D+F    + D+ VR+ FI+KVY I++ QLL+T   IA+F FVEP+ K+V+ N   YY+S+A+F+VTY+ L CC G RR++P N   L+IFTLAL ++T TI+S YET AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VL++T    GI+ + +   K +   H VYA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DIV +F  +L L G+++
Sbjct:   78 GSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWNIILLTIFTLALGFVTGTISSMYETKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVT----GIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

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BLAST of Protein lifeguard 2 vs. Ensembl Mouse
Match: Faim2 (Fas apoptotic inhibitory molecule 2 [Source:MGI Symbol;Acc:MGI:1919643])

HSP 1 Score: 201.83 bits (512), Expect = 2.109e-61
Identity = 111/248 (44.76%), Postives = 160/248 (64.52%), Query Frame = 2

Query:  278 PQPPYQGAGDMYGGDNFAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P  P     D    ++F  FS  D+ VR  FIRKVY I+  QLLVT   +A+F F + ++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L+IFTL+++Y+T  ++S+Y T +VL+   ITA+VC+S+TIF+ QTK DFT C G++     VLL+T    G++ A + P + V   HAVYA L   VF ++L +DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   61 PLHPSWAYVDPRHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVL----FVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 304

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Mouse
Match: Faim2 (Fas apoptotic inhibitory molecule 2 [Source:MGI Symbol;Acc:MGI:1919643])

HSP 1 Score: 201.445 bits (511), Expect = 3.926e-61
Identity = 110/244 (45.08%), Postives = 160/244 (65.57%), Query Frame = 2

Query:  290 YQGAGDMYGGDNFAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            Y+G       ++F  FS  D+ VR  FIRKVY I+  QLLVT   +A+F F + ++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L+IFTL+++Y+T  ++S+Y T +VL+   ITA+VC+S+TIF+ QTK DFT C G++     VLL+T    G++ A + P + V   HAVYA L   VF ++L +DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   77 YEGGFPAGHHEHFTTFSWDDQKVRRLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLVITALVCLSVTIFSFQTKFDFTSCQGVL----FVLLMTLFFSGLLLAVLLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 316

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BLAST of Protein lifeguard 2 vs. Ensembl Mouse
Match: Grina (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding) [Source:MGI Symbol;Acc:MGI:1913418])

HSP 1 Score: 201.445 bits (511), Expect = 8.955e-61
Identity = 114/255 (44.71%), Postives = 162/255 (63.53%), Query Frame = 2

Query:  239 PPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFS-DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            P  PQ  NYQ        +G    Y   +F A + DK++R  FIRKV+L++T QL VT   +A+F FV  ++ +V+ N W YY+S+AIF ++ I L CC   RRK+P N  ALSI T++LSYM   IASFY T AV++A GIT  VC ++ IF+MQT+ DFT C G++LV  +VL +  + C  I      ++++  VYA L  L+F  +L  DTQL++G ++  LSPE+Y+  AL LY DI+N+FL IL++ G 
Sbjct:  100 PGSPQHGNYQE-------EGPPSYYDNQDFPAVNWDKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIR-----NRILEIVYASLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGR 342

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BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Match: sp|Q969X1|LFG3_HUMAN (Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMBIM1 PE=1 SV=2)

HSP 1 Score: 213.772 bits (543), Expect = 3.861e-65
Identity = 118/248 (47.58%), Postives = 168/248 (67.74%), Query Frame = 2

Query:  296 GAGDMYGGDNFAA--------FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G G  Y G+  A         + D+ VR+ FIRKVY I++ QLL+T   IA+F FVEP+  +V+RN   YY+S+A+F+VTY+ L CC G RR++P N   L++FT A+ +MT TI+S Y+T AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VLL+T    GI+ + +   + V   H +YA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DI+ +F  +L L G++N
Sbjct:   68 GPGHGYDGEERAVSDSFGPGEWDDRKVRHTFIRKVYSIISVQLLITVAIIAIFTFVEPVSAFVRRNVAVYYVSYAVFVVTYLILACCQGPRRRFPWNIILLTLFTFAMGFMTGTISSMYQTKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLLVT----GIVTSIVLYFQYVYWLHMLYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIIYIFTFVLQLMGDRN 311

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BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Match: sp|Q8BJZ3|LFG3_MOUSE (Protein lifeguard 3 OS=Mus musculus OX=10090 GN=Tmbim1 PE=1 SV=1)

HSP 1 Score: 213.386 bits (542), Expect = 4.914e-65
Identity = 116/236 (49.15%), Postives = 166/236 (70.34%), Query Frame = 2

Query:  314 GGDNF--AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            G D+F    + D+ VR+ FI+KVY I++ QLL+T   IA+F FVEP+ K+V+ N   YY+S+A+F+VTY+ L CC G RR++P +   L+IFTLAL ++T TI+S YE  AV++A  ITA+V IS+TIF  QTK+DFT C+G+  VL +VL++T    GI+ + +   K +   H VYA L  + F ++L YDTQLV+G RK+ +SPEDYI GALQ+Y DIV +F  +L L G+++
Sbjct:   78 GSDSFRPGEWDDRKVRHSFIQKVYCIISVQLLITVAIIAIFTFVEPVGKYVRNNVAVYYVSYAVFLVTYLTLACCQGPRRRFPWDIILLTIFTLALGFVTGTISSMYENKAVIIAMIITAVVSISVTIFCFQTKVDFTSCTGLFCVLGIVLMVT----GIVTSIVLIFKYIYWLHMVYAALGAICFTLFLAYDTQLVLGNRKHTISPEDYITGALQIYTDIVYIFTFVLQLVGSRD 309

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BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Match: sp|Q9BWQ8|LFG2_HUMAN (Protein lifeguard 2 OS=Homo sapiens OX=9606 GN=FAIM2 PE=1 SV=1)

HSP 1 Score: 206.068 bits (523), Expect = 5.287e-62
Identity = 110/237 (46.41%), Postives = 159/237 (67.09%), Query Frame = 2

Query:  317 GDN--FAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            GD+  F  FS  D+ VR  F+RKVY I+  QLLVT   +A+F F +P++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L++FTL+++Y+T  ++S+Y T +VL+  GITA+VC+S+T+F+ QTK DFT C G++     VLL+T    G+I A + P + V   HAVYA L   VF ++L  DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   83 GDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVL----FVLLMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 315

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BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Match: sp|Q5R4I4|LFG2_PONAB (Protein lifeguard 2 OS=Pongo abelii OX=9601 GN=FAIM2 PE=2 SV=1)

HSP 1 Score: 205.682 bits (522), Expect = 7.523e-62
Identity = 109/237 (45.99%), Postives = 158/237 (66.67%), Query Frame = 2

Query:  317 GDN--FAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            GD+  F  FS  D+ VR  F+RKVY I+  QLLVT   +A+F F +P++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L++FTL+++Y+T  ++S+Y T +VL+  GITA+VC+S+T+F+ QTK DFT C G++     VL +T    G+I A + P + V   HAVYA L   VF ++L  DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   83 GDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAVVALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVL----FVLPMTLFFSGLILAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 315

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BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Match: sp|O88407|LFG2_RAT (Protein lifeguard 2 OS=Rattus norvegicus OX=10116 GN=Faim2 PE=2 SV=1)

HSP 1 Score: 204.142 bits (518), Expect = 2.862e-61
Identity = 115/264 (43.56%), Postives = 166/264 (62.88%), Query Frame = 2

Query:  230 TVYPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFS--DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            T  P  P  + Y        Y+G       + F+ FS  D+ VR  FIRKVY I+  QLLVT   +A+F F + ++ +V+ NP +Y+ S+A+F  TY+ L CC G RR +P N   L+IFTL+++Y+T  ++S+Y T +VL+  GITA+VC+S+TIF+ QTK DFT C G++     VLL+T    G++ A + P + V   HAVYA L   VF ++L +DTQL++G R++ LSPE+YI GAL +YLDI+ +F   L LFG   
Sbjct:   57 TAVPLHPS-WAYVDPSSSSGYEGGFPAGHHELFSTFSWDDQKVRQLFIRKVYTILLVQLLVTLAVVALFTFCDVVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTIFTLSMAYLTGMLSSYYNTTSVLLCLGITALVCLSVTIFSFQTKFDFTSCHGVL----FVLLMTLFFSGLLLAILLPFQYVPWLHAVYAVLGAGVFTLFLAFDTQLLMGNRRHSLSPEEYIFGALNIYLDIIYIFTFFLQLFGTNR 315

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BLAST of Protein lifeguard 2 vs. TrEMBL
Match: A0A3R7C8S7 (Protein lifeguard 3 (Fragment) OS=Clonorchis sinensis OX=79923 GN=Tmbim1 PE=3 SV=1)

HSP 1 Score: 296.59 bits (758), Expect = 1.983e-95
Identity = 150/253 (59.29%), Postives = 198/253 (78.26%), Query Frame = 2

Query:  257 YNYQATEPQPPYQGAGDMYGGDNF---AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            Y++   +PQ    G      G+ F   A FSDKSVR+ FIRKVYLI+TAQLLVTC  +++F    P++ WV+RN WFYY+S+A F+VTYI LVCC  VRR++PGNF ALS+FTLA SY+  TIASF+ T +VL+A GITA VC+ I++FA+QT+IDFT C+ +I VLSLV+LLTGL+C I+Y   GP+K++H VY GL  L+FG+YL +DTQ+++GGRK+ELSPE+YI GALQLYLD+V +F+IILSL G+K+
Sbjct:   23 YSHPYPDPQSQPYGEYSASAGNAFTSSARFSDKSVRHAFIRKVYLILTAQLLVTCGIVSLFLLAHPVKYWVQRNSWFYYISYATFLVTYITLVCCDNVRRRFPGNFIALSVFTLAFSYVAGTIASFHNTDSVLIAVGITAAVCLGISLFAIQTRIDFTKCTALIFVLSLVVLLTGLACMIVYMVSGPNKILHVVYGGLAALLFGLYLAFDTQMIMGGRKHELSPEEYIYGALQLYLDVVYLFMIILSLVGSKD 275

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BLAST of Protein lifeguard 2 vs. TrEMBL
Match: G7Y2U8 (Fas apoptotic inhibitory molecule 2 OS=Clonorchis sinensis OX=79923 GN=CLF_100173 PE=3 SV=1)

HSP 1 Score: 295.434 bits (755), Expect = 1.489e-94
Identity = 150/253 (59.29%), Postives = 198/253 (78.26%), Query Frame = 2

Query:  257 YNYQATEPQPPYQGAGDMYGGDNF---AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            Y++   +PQ    G      G+ F   A FSDKSVR+ FIRKVYLI+TAQLLVTC  +++F    P++ WV+RN WFYY+S+A F+VTYI LVCC  VRR++PGNF ALS+FTLA SY+  TIASF+ T +VL+A GITA VC+ I++FA+QT+IDFT C+ +I VLSLV+LLTGL+C I+Y   GP+K++H VY GL  L+FG+YL +DTQ+++GGRK+ELSPE+YI GALQLYLD+V +F+IILSL G+K+
Sbjct:   51 YSHPYPDPQSQPYGEYSASAGNAFTSSARFSDKSVRHAFIRKVYLILTAQLLVTCGIVSLFLLAHPVKYWVQRNSWFYYISYATFLVTYITLVCCDNVRRRFPGNFIALSVFTLAFSYVAGTIASFHNTDSVLIAVGITAAVCLGISLFAIQTRIDFTKCTALIFVLSLVVLLTGLACMIVYMVSGPNKILHVVYGGLAALLFGLYLAFDTQMIMGGRKHELSPEEYIYGALQLYLDVVYLFMIILSLVGSKD 303

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BLAST of Protein lifeguard 2 vs. TrEMBL
Match: A0A183LH72 (Uncharacterized protein OS=Schistosoma margrebowiei OX=48269 GN=SMRZ_LOCUS3147 PE=3 SV=1)

HSP 1 Score: 293.508 bits (750), Expect = 5.729e-94
Identity = 151/256 (58.98%), Postives = 196/256 (76.56%), Query Frame = 2

Query:  245 QPQVYNYQATEPQPPYQGAGDMYGGDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +P  Y    ++ +P Y   G      NF +  +SDK VR+ FIRKVYLI+TAQLLVT  F+ VF F  P++KWV RN WFYYLS+A F+ TYIALVCCP VRR+YPGN  ALS+FTLA SYMT TI SFY+T +VLVA  ITA +CI+I++FA+QT+ID T C+ +I VLS+V++LTGL+C I++A  GP++++  VY GL  L+FG+YL +DTQ +IGGR+ ELS E+YI GALQLYLD+VN+FLIILS FGN++
Sbjct:   35 EPAGYQDNPSDQEPKYNRNG------NFTSLQYSDKYVRHAFIRKVYLILTAQLLVTSAFVCVFLFSSPVKKWVSRNSWFYYLSYATFLCTYIALVCCPSVRRRYPGNVIALSVFTLAFSYMTGTITSFYDTQSVLVAVVITACLCIAISVFAIQTRIDITKCTSLIFVLSIVVMLTGLACIIVFAVSGPNRILQVVYGGLAALLFGVYLAFDTQHIIGGRELELSAEEYIFGALQLYLDVVNLFLIILSFFGNRD 284

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BLAST of Protein lifeguard 2 vs. TrEMBL
Match: A0A183QQ07 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=3 SV=1)

HSP 1 Score: 290.041 bits (741), Expect = 5.162e-93
Identity = 148/256 (57.81%), Postives = 196/256 (76.56%), Query Frame = 2

Query:  245 QPQVYNYQATEPQPPYQGAGDMYGGDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +P  Y   +++ +P Y   G      NF +  +SDK VR+ FIRKVYLI+TAQLLVT  F+ VF F  P++KWV RN WFYYLS+A F+ TYIALVCCP VRR+YPGN  ALS+FTLA SYMT T+ASFY+T +VL+A  ITA +CI+I+IFA+QT+ID T C+ +I VL++V++LTGL+C I++A   P+ ++  VY GL  L+FG+YL +DTQ ++GGR+ ELS E+YI GALQLYLD+VN+FLIILS FGN++
Sbjct:   14 EPAGYQDNSSDQEPKYNRNG------NFTSLQYSDKYVRHAFIRKVYLILTAQLLVTSAFVCVFLFSSPVKKWVSRNSWFYYLSYATFLCTYIALVCCPSVRRRYPGNVIALSVFTLAFSYMTGTVASFYDTQSVLIAVIITACLCIAISIFAIQTRIDITKCTSLIFVLTIVVMLTGLACVIVFAVSKPNWILQVVYGGLAALLFGVYLAFDTQHIMGGRELELSAEEYIFGALQLYLDVVNLFLIILSFFGNRD 263

[Close]

BLAST of Protein lifeguard 2 vs. TrEMBL
Match: A0A3Q0KPN6 (Putative recs1 protein (Responsive to centrifugal force and shear stressprotein 1 protein) OS=Schistosoma mansoni OX=6183 PE=3 SV=1)

HSP 1 Score: 285.419 bits (729), Expect = 7.392e-91
Identity = 147/256 (57.42%), Postives = 194/256 (75.78%), Query Frame = 2

Query:  245 QPQVYNYQATEPQPPYQGAGDMYGGDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +P  Y   +++ +P Y   G      NF +  +SDK VR+ FIRKVYLI+TAQLLVT  F+ VF F  P++ WV RN WFYYLS+A F+ TYIALVCCP VRR+YPGN  ALS+FTLA SYMT TI SFY+T +VL+A  ITA +CI+I+IFA+QT+ID T C+ +I VL++V++LTGL+C I++A   P+ ++  VY GL  L+FG+YL +DTQ ++GGR+ ELS E+YI GALQLYLD+VN+FLIILS FGN++
Sbjct:   34 EPAGYQDNSSDQEPKYNRNG------NFTSLQYSDKYVRHAFIRKVYLILTAQLLVTSAFVCVFLFSSPVKYWVSRNSWFYYLSYATFLCTYIALVCCPSVRRRYPGNVIALSVFTLAFSYMTGTITSFYDTQSVLIAVIITACLCIAISIFAIQTRIDITKCTSLIFVLTIVVMLTGLACVIVFAVSKPNWILQVVYGGLAALLFGVYLAFDTQHIMGGRELELSAEEYIFGALQLYLDVVNLFLIILSFFGNRD 283

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BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Match: grinab (protein lifeguard 1-like [Source:NCBI gene;Acc:103028312])

HSP 1 Score: 221.09 bits (562), Expect = 1.662e-68
Identity = 125/261 (47.89%), Postives = 174/261 (66.67%), Query Frame = 2

Query:  239 PPQPQVYNYQATEP-QPPYQGAGD--MYGGDNF--AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P QP  Y Y  +EP   PYQ   +   Y  D+   + F DK+VR  FIRKV+L++TAQL+VT  F+A+F F + I+ +V++N W YY+S+A+FI+  IA+ CC   RRK+P N  ALSI TL++SYMT  IASFY+T  V++A GIT +VC ++ IF+MQ+K DFT C G++ V  +VL + G+ C  I      +K++  VYA L  LVF  +L  DTQL++G +K  LSPE+Y+ GAL LYLDI+N+FL IL + G   
Sbjct:   89 PSQP--YQYHPSEPMSDPYQSTDEPPAYDHDDIRISGFDDKAVRRAFIRKVFLVLTAQLVVTFSFVALFTFEKNIKTFVQQNVWTYYVSYAVFIIPLIAISCCGEFRRKHPWNLVALSILTLSMSYMTGMIASFYDTDTVVMAVGITVVVCFTVVIFSMQSKYDFTSCMGVLFVCVIVLFVFGILCIFIR-----NKILDIVYASLGALVFTCFLAVDTQLLLGNKKLSLSPEEYVFGALNLYLDIINIFLYILQIVGRSR 342

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BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Match: grinab (protein lifeguard 1-like [Source:NCBI gene;Acc:103028312])

HSP 1 Score: 218.009 bits (554), Expect = 6.992e-67
Identity = 120/254 (47.24%), Postives = 171/254 (67.32%), Query Frame = 2

Query:  245 QPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +P    YQ+T+ +PP     D+      + F DK+VR  FIRKV+L++TAQL+VT  F+A+F F + I+ +V++N W YY+S+A+FI+  IA+ CC   RRK+P N  ALSI TL++SYMT  IASFY+T  V++A GIT +VC ++ IF+MQ+K DFT C G++ V  +VL + G+ C  I      +K++  VYA L  LVF  +L  DTQL++G +K  LSPE+Y+ GAL LYLDI+N+FL IL + G   
Sbjct:  137 EPMSDPYQSTD-EPPAYDHDDI----RISGFDDKAVRRAFIRKVFLVLTAQLVVTFSFVALFTFEKNIKTFVQQNVWTYYVSYAVFIIPLIAISCCGEFRRKHPWNLVALSILTLSMSYMTGMIASFYDTDTVVMAVGITVVVCFTVVIFSMQSKYDFTSCMGVLFVCVIVLFVFGILCIFIR-----NKILDIVYASLGALVFTCFLAVDTQLLLGNKKLSLSPEEYVFGALNLYLDIINIFLYILQIVGRSR 380

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Match: grinaa (glutamate ionotropic receptor NMDA type subunit associated protein 1 [Source:NCBI gene;Acc:103028129])

HSP 1 Score: 212.616 bits (540), Expect = 4.452e-65
Identity = 123/282 (43.62%), Postives = 171/282 (60.64%), Query Frame = 2

Query:  242 PQPQVYNYQATEPQPPYQ----------------GAGDMYGGD---------NFA--AFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P PQ    Q   PQ PYQ                G+   +GGD          FA   + DKS+R  FIRKV++++T QL+VT  F+AVF F   ++ +V++N W YY+S+ +F V+ IAL CC   RRK+P N  ALSI TL+LSYM   IASFY T +V++A GIT++VC S+ IF++Q+K DFT C G++ V  +VL+L    C +I       K++H VYA L  L+F  +L  DTQL++G +K  LSPE+YI  AL LY DI+N+F+ IL++ G   
Sbjct:   78 PYPQGPYPQGPYPQGPYQQGPGQPGFGMDPNAPLGSPGYHGGDGPPSYYDNEEFANSGWEDKSIRQAFIRKVFMVLTVQLMVTFSFVAVFTFSNDVKLFVRQNRWTYYVSYVVFFVSLIALSCCGEFRRKHPWNLVALSILTLSLSYMVGMIASFYNTDSVIIAVGITSVVCFSVVIFSLQSKYDFTSCRGVLFVCLIVLILFSFLCMVIR-----HKILHIVYASLGALLFTCFLAVDTQLLLGNKKLALSPEEYIFAALNLYTDIINIFMYILAIVGRSR 354

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:103036676])

HSP 1 Score: 204.912 bits (520), Expect = 4.185e-62
Identity = 106/237 (44.73%), Postives = 155/237 (65.40%), Query Frame = 2

Query:  305 DMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            D  G      +   SVR+ FIRKVY+I+ AQLL+T   +AVF FV+P++ +V RNP  Y+ S+A++ +T+I LVCC G RR++P N   L IFTLA+SYM  TI+S+Y+T +V +A GIT IVCI++T+F  QTK+DFT C G+      VL +     GII A +   K +   H +YA +  + F ++L Y TQL+IG RK+ +SPE+Y+  AL +Y+D++ +FL +L + G   
Sbjct:  123 DDEGFTTSPGWESLSVRHTFIRKVYMILAAQLLLTVSIVAVFTFVQPVRTFVVRNPGVYWASYAVYFITHIMLVCCKGPRRRFPWNLILLGIFTLAMSYMAGTISSYYDTKSVFLALGITVIVCIAVTVFCFQTKVDFTKCGGLF----CVLGIVVFVTGIITAIVLSFKYIPWLHMLYAAIGAIAFTLFLAYHTQLLIGNRKHSISPEEYVFAALSIYVDVIQIFLFLLQIIGASQ 355

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Match: tmbim1b (protein lifeguard 3-like [Source:NCBI gene;Acc:111197343])

HSP 1 Score: 201.06 bits (510), Expect = 5.410e-61
Identity = 121/287 (42.16%), Postives = 178/287 (62.02%), Query Frame = 2

Query:  236 YPPQPQVYNYQATEPQPPYQGAGDMYGG---------------------------DNFAA---FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            YPPQP VY  Q      P   AG  YG                            +++AA   +  +SVR+ FIRKVYLI+ AQL VT   +AVF FV+P++ +V + P  Y+ SFA++ VTY+ LVCC   RR+ P N   L +FTLA+SYMT T+AS+++T AV +A GITA+VCI++TIF+ QTK+DFT C+G++ VL +V+L+TG+   I+  +      +H +YA +  + + ++L Y TQ++IG R + LSPE+YI  AL LY+DIV +F+ +L + G+ +
Sbjct:   34 YPPQPVVYGGQEQPGVHP--SAGPWYGQGYPASGMPSFIPAYVPSGMPSSDPEVREDYAADGLWESRSVRHAFIRKVYLILAAQLTVTASIVAVFTFVDPVRLFVIKYPAIYWASFAVYFVTYLVLVCCEKPRRRVPWNLLLLFVFTLAMSYMTGTLASYFDTKAVFLALGITAVVCIAVTIFSFQTKVDFTSCTGLLCVLGVVVLVTGIITTIV-LSFQYVPWLHMLYAAIGAIAYTLFLAYHTQVLIGNRSHTLSPEEYIYAALSLYVDIVQIFIFLLQITGSSS 317

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BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 216.083 bits (549), Expect = 9.995e-68
Identity = 116/232 (50.00%), Postives = 163/232 (70.26%), Query Frame = 2

Query:  317 GDNFAA--FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            GD+F++  + DK++R  FIRKVY I+  QLLVT   +A+F   EP+  +VKRNP  Y+ S+A+F+VTY+ L CC   RR++P N   LSIFTLA+SYMT T+ASFY T +V++  GITA+VC S+TIF  QTK DFT C G++ VL + L+LTGL   I     G    +H VY GL  +VF ++L YDTQL+IG R+Y +SPE++I  +L LY+D+V +F+ +L +FG++ 
Sbjct:   76 GDSFSSNTWEDKNLRRVFIRKVYAILMLQLLVTFGIVAIFTLCEPVGYYVKRNPILYWSSYAVFLVTYLVLACCKEPRRRFPLNIILLSIFTLAMSYMTGTLASFYSTRSVMLCFGITALVCFSVTIFCFQTKFDFTTCHGLLFVLLMALVLTGLVAAIA-VPFGYMPWLHVVYGGLGAVVFTLFLAYDTQLLIGNRRYAISPEEHIFASLNLYMDLVYIFMFLLQIFGSRE 306

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BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 201.83 bits (512), Expect = 3.198e-63
Identity = 106/226 (46.90%), Postives = 157/226 (69.47%), Query Frame = 2

Query:  329 AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
              + D++VR  F+RKVY I+  QLLVT   +AVF F E ++++V+R P  Y+ S+ +F VTY+ L+CC   RR +P N+  LS+FTLA++YMT  +AS+Y T +VL+  GITA+VC ++T+F  QTK DFT C G++ VLS+ LLLTGL   +     G    +  VYAGL  +VF ++L +DTQL++G R++ +SPE+++ GAL LY+DIV +F  +L LFG ++
Sbjct:    2 GTWDDRNVRRVFVRKVYTILMLQLLVTFGIVAVFTFNESVERFVRRTPAIYWTSYGVFFVTYLVLICCTKARRMFPLNYILLSVFTLAMAYMTGMLASYYSTKSVLMCLGITAMVCAAVTLFCFQTKFDFTSCHGLMFVLSMALLLTGLV-AVFTVPFGYIPWIQTVYAGLGAVVFTLFLAFDTQLLLGNRRHSISPEEHVYGALSLYMDIVYIFTFMLQLFGTRD 226

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BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Match: grinaa (glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1a (glutamate binding) [Source:ZFIN;Acc:ZDB-GENE-060616-231])

HSP 1 Score: 184.882 bits (468), Expect = 3.183e-56
Identity = 108/243 (44.44%), Postives = 149/243 (61.32%), Query Frame = 2

Query:  275 EPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNK 1003
            E  P Y    D     N + ++DK+VR  FIRKVYL++TAQL                  +VK  P  YY S+A+F V  IAL CC   RRK+P N   LSI TL +SYM   IA+FYE  AV++A GIT  VC+++ +F+MQTK DFT C+G++LV+ +VL+L  + C I+      + +++ VY  L  L+F ++L  DTQL++G  KY LSPE+YI  AL LY D++N+FL IL + GN 
Sbjct:   47 EHPPIYHDNEDF----NISDWTDKTVRRAFIRKVYLVLTAQL----------------PTYVKSTPGLYYASYAVFFVCLIALSCCGEFRRKHPWNIITLSILTLCMSYMVGMIATFYEADAVVMAMGITVAVCVAVILFSMQTKYDFTSCNGVLLVMLVVLMLFSILCIILR-----NHILNIVYGALGALLFTVFLAVDTQLLMGNHKYALSPEEYIFAALNLYTDVINIFLYILMIIGNS 264

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 181.03 bits (458), Expect = 2.980e-55
Identity = 101/215 (46.98%), Postives = 148/215 (68.84%), Query Frame = 2

Query:  371 KVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKV---VHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +VY+I+  QLLVT  F+AV  FV P++ +V++NP  Y+ S+ +F  TY+ LVCC   RR +P NF  L++ TLA+SY+T  +ASFY T +VL+  G+TA VC ++T+F  QTK+DFT C G++  LS+VLLLT    G+I A   P      +  VYAGL  ++F ++L  DTQL++G R+  +SPE++I GAL+LY+DIV +F  +L L G++N
Sbjct:    8 QVYIILFVQLLVTFGFVAVCTFVVPVKTFVQKNPAMYWASYGVFFATYLGLVCCTKARRLFPLNFILLAVLTLAMSYLTGMLASFYNTNSVLMCIGVTAAVCGAVTLFCFQTKVDFTSCPGVMFALSMVLLLT----GLIAAFTVPFGYIPWIQTVYAGLGAVIFTVFLAVDTQLLLGNRRNSISPEEHINGALRLYMDIVYIFTFLLQLIGSRN 218

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Match: faim2a (Fas apoptotic inhibitory molecule 2a [Source:ZFIN;Acc:ZDB-GENE-050320-88])

HSP 1 Score: 134.806 bits (338), Expect = 1.896e-38
Identity = 77/164 (46.95%), Postives = 113/164 (68.90%), Query Frame = 2

Query:  524 VCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKV---VHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            +C  G+RR +P NF  L++ TLA+SY+T  +ASFY T +VL+  G+TA VC ++T+F  QTK+DFT C G++  LS+VLLLT    G+I A   P      +  VYAGL  ++F ++L  DTQL++G R+  +SPE++I GAL+LY+DIV +F  +L L G++N
Sbjct:    1 LCMTGLRRLFPLNFILLAVLTLAMSYLTGMLASFYNTNSVLMCIGVTAAVCGAVTLFCFQTKVDFTSCPGVMFALSMVLLLT----GLIAAFTVPFGYIPWIQTVYAGLGAVIFTVFLAVDTQLLLGNRRNSISPEEHINGALRLYMDIVYIFTFLLQLIGSRN 160

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Yeast
Match: BXI1 (Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p [Source:SGD;Acc:S000005249])

HSP 1 Score: 70.0922 bits (170), Expect = 6.419e-14
Identity = 72/297 (24.24%), Postives = 126/297 (42.42%), Query Frame = 2

Query:  239 PPQPQVYNYQATE--PQPPYQGAGDMYGGDNFAAFS-----DKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPG------------------------------VRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGM----IXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            PP P  Y  Q++    QP     G+ +  ++F   +     +  +R  F+ KVY +++ QLL +  F         +Q ++  +   +Y+   + +V+ I L   P                               V   Y      LSIFTL+ +Y  + +   Y+   VL A  IT IV + +++ A+  + +  + S       L   L +++      +++     S   + +Y  L  ++F  YL  DTQL+   RK  + P++ +  A+ LYLDIVN+FL IL +  N N
Sbjct:    4 PPPP--YEEQSSHLYGQPASSQDGNAFIPEDFKYSTVVISCEPIIRQRFMHKVYSLLSCQLLASLSFCYWASVSTSLQNFIMSHIALFYICMVVSLVSCIWLAVSPRPEDYEASVPEPLLTGSSEEPAQEQRRLPWYVLSSYKQKLTLLSIFTLSEAYCLSLVTLAYDKDTVLSALLITTIVVVGVSLTALSERFENVLNSATSIYYWLNWGLWIMIGMGLTALLFGWNTHSSKFNLLYGWLGAILFTAYLFIDTQLIF--RK--VYPDEEVRCAMMLYLDIVNLFLSILRILANSN 294

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Nematostella
Match: EDO37574 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SFG5])

HSP 1 Score: 187.578 bits (475), Expect = 3.986e-57
Identity = 114/233 (48.93%), Postives = 149/233 (63.95%), Query Frame = 2

Query:  296 GAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRK-YELSPEDYIEGALQLYLDIVNMFLIILSL 991
            GA D +  DN  AFSD S+R GFIRKVY I+  QL VT  FI  F + EP++ +   +P  +Y + A+  VT IA+ CC GVRRK+P N   L++FTL   Y+   ++S Y+   VL+A GITA+V ++ITIFA QTK DFTM  G +      + L  L C    A    ++VV  VYA L  L+F +YL+YDTQ+++GG K Y +SPE+YI  AL LYLDIVNMFL IL L
Sbjct:   15 GADDPFA-DNSMAFSDISIRAGFIRKVYSILLCQLAVTISFICFFLYCEPVRLYAVSHPGIFYGALAVTFVTMIAMACCEGVRRKFPTNLLFLTLFTLCEGYLLGAVSSVYKADEVLMAVGITAVVVLAITIFAFQTKYDFTMMGGFL-----FVALIVLICFGFLAIFFHNRVVQIVYASLGALLFALYLVYDTQIMMGGGKMYSISPEEYIFAALNLYLDIVNMFLYILQL 241

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Nematostella
Match: EDO49375 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG77])

HSP 1 Score: 181.8 bits (460), Expect = 4.933e-54
Identity = 117/266 (43.98%), Postives = 163/266 (61.28%), Query Frame = 2

Query:  242 PQPQVYNYQATEP--QPPYQGAG-DM-YGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKR-----NPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGI---IYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNK 1003
            P P  Y+    +P  QP   G G D+ YGG    +FSDKS+R GFIR+VY I+  QL VT   I +F F +P++ +V       N   Y  +F +F V Y  + CC  VRRKYP N   L+IFTLALSY+  TI+S+++T  VL+  G+T +VC+S+ IF+ QTK DFT   G++   +L +    +   +   +  T G       V  G+  LVF  +L YDTQL++GG+KYELSPE+YI GAL LY+DI+ +FL++L+LFG K
Sbjct:   61 PPPPSYDSAIAKPLEQPSSYGDGYDVEYGGA--VSFSDKSIRMGFIRRVYFILMIQLSVTVATICLFLFYKPVRNFVHGKHGAGNTVVYVSAFVVFFVLYFVIACCESVRRKYPVNLICLAIFTLALSYLVGTISSYHDTNIVLIMMGVTTLVCLSVMIFSCQTKYDFTTWGGVLFCAALAIFFLSIFTPVWLLLNTTAG-----KIVLGGVLALVFVAFLAYDTQLIMGGKKYELSPEEYIFGALTLYMDIIRIFLLLLALFGKK 319

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Nematostella
Match: EDO48159 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RKF0])

HSP 1 Score: 102.834 bits (255), Expect = 1.908e-25
Identity = 68/218 (31.19%), Postives = 125/218 (57.34%), Query Frame = 2

Query:  338 SDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSL 991
            ++ +VR GF+RKVY I++AQL +T L  A+F     I+ +V+  P    + F  FI+++  L+     RR+ P N + L  FTL  +Y   T+ +F++   VL A G+TA   I++T++ +Q+K D++     +      +L   +  G++      S ++   YA L  L+F  ++++DT +++     ++SPE+YI  ++ LY+DI+N+F+ IL +
Sbjct:   17 TNINVRLGFLRKVYGILSAQLGLTILVSALFMSTPAIKDFVQSRP---EVLFVAFILSFGFLIALMFKRRESPMNMYLLFGFTLVEAYTLGTLVTFFDRMIVLEAFGMTAATTIALTMYTLQSKRDYSSWGAGL----FTMLWIFIWAGLL-QMFFQSDILELAYAVLGALLFSAFIVFDTHMLMN----KMSPEEYILASINLYMDIINLFIQILKI 222

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Match: tmbim1a (transmembrane BAX inhibitor motif containing 1 [Source:NCBI gene;Acc:101159382])

HSP 1 Score: 217.624 bits (553), Expect = 3.632e-67
Identity = 116/235 (49.36%), Postives = 160/235 (68.09%), Query Frame = 2

Query:  314 GGDNFAA----FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
             G+ FAA    + D  VR+ FIRKVYLI+ +QLL+T   +A+F FV P++ +V+ NP  Y+ S+AI+I+T+I LVCC G RRKYP N   L IFTLALSYMT TI+SFY+T +V +A GITA+VCI++T+F  QTK+DFT C G+      VL +     GII A +   K +   H +YA +  +VF ++L Y TQL+IG RKY +S E+Y+  AL +Y+DIV +FL +L + G
Sbjct:  102 SGEEFAARGSNWEDLRVRHSFIRKVYLILASQLLLTTAIVAIFTFVHPVKTFVRDNPAVYWASYAIYIITHIVLVCCKGPRRKYPWNLILLLIFTLALSYMTGTISSFYDTKSVFLALGITAVVCIAVTVFCFQTKVDFTKCQGLF----CVLGIVVFVTGIIAAIVLSFKYILWLHMLYAAIGAIVFTLFLAYHTQLLIGNRKYSISEEEYVFAALSIYVDIVQIFLFLLQIIG 332

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Match: grinaa (protein lifeguard 1 [Source:NCBI gene;Acc:101164659])

HSP 1 Score: 217.624 bits (553), Expect = 4.504e-67
Identity = 118/246 (47.97%), Postives = 159/246 (64.63%), Query Frame = 2

Query:  281 QPPYQGAGDMYGGDN----FAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
             P Y   G    GDN         DK+VR  FIRKV+L++T QL+VT  F+A+F F +  + +V+RNPW YY S+A F+V  IAL CC   RRKYPGNF AL I TL+LSYM   IASFY+T  V++A GITA VC ++ +F++QTK DFT C G++ V  +VL++  + C  I      +K++H VYA L  L+F  +L  DTQL++G +   LSPE+YI  AL LY DI+N+FL IL++ G   
Sbjct:  103 SPAYHDDGPPSYGDNDEFKIGGLEDKTVRRAFIRKVFLVLTVQLVVTFSFVAIFTFSDDAKIFVRRNPWVYYTSYASFLVCLIALSCCGDFRRKYPGNFIALGILTLSLSYMVGMIASFYDTETVIIAVGITAGVCFTVVLFSLQTKYDFTSCRGVLFVCLIVLMIFSILCIFIR-----NKIMHLVYASLGALLFTCFLAVDTQLLLGNKNLALSPEEYIFAALNLYTDIINIFLYILAIVGRSR 343

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Match: grinab (protein lifeguard 1 [Source:NCBI gene;Acc:101161330])

HSP 1 Score: 216.468 bits (550), Expect = 9.700e-67
Identity = 116/249 (46.59%), Postives = 168/249 (67.47%), Query Frame = 2

Query:  263 YQATEPQPPYQGAGD-MYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            Y   E  PP+    D M G DN      KS+R  F+RKV+L++TAQL+VT  F+A+F FV+ ++ +VK N W Y +S+ IFIV  +A+ CC  +RRK+P N  ALSI TL++SYM   IASF++T +V++A GITA+VC ++ IF++QTK DFT C G++ V  +VL++ G  C  I      +K++  VYAGL  L+F  +L  DTQL++G ++  LSPE+Y+  AL LYLDI+N+FL IL++ G  +
Sbjct:  100 YHGEEAPPPFHDNQDFMIGLDN------KSIRRAFVRKVFLVLTAQLMVTFAFVAIFTFVKEVKAFVKVNIWTYIVSYVIFIVALLAISCCGNLRRKHPWNLVALSILTLSMSYMVGMIASFHDTDSVIMAVGITAVVCFTVVIFSLQTKYDFTSCYGVLFVCLIVLIIFGFLCIFI-----QNKILEIVYAGLGALLFTCFLAVDTQLLLGNKELSLSPEEYVFAALNLYLDIINIFLYILAIVGRAS 337

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Match: faim2b (protein lifeguard 2-like [Source:NCBI gene;Acc:101164304])

HSP 1 Score: 179.104 bits (453), Expect = 1.889e-53
Identity = 99/254 (38.98%), Postives = 155/254 (61.02%), Query Frame = 2

Query:  275 EPQPPYQGAGDMYGG-DNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKID--------FTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            EP P YQ A   YG  +   A+ DK++R  FIRKVY I+  QL VT   +++F F  P++ +++ +P  Y +S+ +F+VTYI L CC  +RRK+P N   L +FTL++++M   ++SFY T +V++  GIT +VC+S+TIF+ Q+KID        F+MC  M+             C I  + + P   V   HA+YA +  ++F ++L +DTQL++G ++Y +SPE+YI   L LYLD++ +F  +L L G 
Sbjct:   11 EP-PSYQEATAGYGEMEAQFAWDDKTIRRTFIRKVYAILMLQLSVTVGIVSLFTFCAPVRFYIQTHPNLYMMSYVMFLVTYIMLSCCGDLRRKFPWNALLLLLFTLSMAFMMGFVSSFYNTKSVILCLGITTLVCLSVTIFSFQSKIDVTSYQGVLFSMCMAML------------LCAITISIVVPFGYVPWLHAIYAVIGAILFTLFLAFDTQLLLGNKRYSISPEEYIFATLSLYLDVIYLFSFMLQLLGG 251

[Close]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Match: tmbim1b (protein lifeguard 3-like [Source:NCBI gene;Acc:101175308])

HSP 1 Score: 180.644 bits (457), Expect = 2.725e-53
Identity = 106/239 (44.35%), Postives = 159/239 (66.53%), Query Frame = 2

Query:  311 YGGDNFAAFSDK----SVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVV---HAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            + GD  A F ++    SVR+ FIRKVYLI+  QL  T   +AVF FV+P++ +V R P  Y+ S A++ V Y  L+C    RR++P N   L IFTLALSYM  TI+S+YET AV +A GIT +VC+++T+F  QTK+D T CSG++ +  ++L++     GI+ A +   + V   H +YA +  +V+ ++L+Y+TQL+IG R+  +SPE+Y+ GAL LY+DIV++FL IL + G+  
Sbjct:   78 HTGDMEAFFRNQWESTSVRHAFIRKVYLILAVQLAFTFTVVAVFTFVDPVRLFVIRYPGIYWASLAVYFVVYCVLICLKEPRRRFPWNLLLLGIFTLALSYMAGTISSYYETKAVFIAMGITVVVCVAVTVFCFQTKVDLTSCSGLLCIAGVLLMII----GIVTAVVLSFQYVHWLHMLYAAIGAVVYTLFLVYNTQLLIGNRELAISPEEYVFGALSLYVDIVHIFLFILQVSGSAT 312

[Close]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Match: SMESG000057144.1 (SMESG000057144.1)

HSP 1 Score: 506.523 bits (1303), Expect = 0.000e+0
Identity = 303/303 (100.00%), Postives = 303/303 (100.00%), Query Frame = 2

Query:   98 MASAPPSYDDVTKXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTVYPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            MASAPPSYDDVTKNPYGPPGGYPQNEPPYPQQQGQYQPYPGNPNTVYPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMILVLSLVLLLTGLSCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN
Sbjct:    1 MASAPPSYDDVTKNPYGPPGGYPQNEPPYPQQQGQYQPYPGNPNTVYPPQPQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMILVLSLVLLLTGLSCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 303

[Close]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Match: SMESG000014373.1 (SMESG000014373.1)

HSP 1 Score: 178.333 bits (451), Expect = 2.988e-52
Identity = 113/264 (42.80%), Postives = 163/264 (61.74%), Query Frame = 2

Query:  242 PQPQVYNYQATEPQPPY-----QGAGDMYGGDNFAA---FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P+PQVY Y +    PP       G   +   D+  A   F+ KS+R  FIRKVY I++ Q+++T   +A+  FVEPI+ WV+RN + Y ++ AI IV  + L C  G RRK+P N   L  FTLA S+M   I+   +T  V  A  IT  + ++ITIFA QTKIDFT  SG +L+LS+V L  G     I+A +  +++V+ +Y  + +L+F I+L+ DTQL++GG   Y +SPEDYI  AL LY+DIV +FL++L +F N +
Sbjct:   83 PRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFG-----IFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 341

[Close]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Match: SMESG000014373.1 (SMESG000014373.1)

HSP 1 Score: 178.333 bits (451), Expect = 3.256e-52
Identity = 113/264 (42.80%), Postives = 163/264 (61.74%), Query Frame = 2

Query:  242 PQPQVYNYQATEPQPPY-----QGAGDMYGGDNFAA---FSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFGNKN 1006
            P+PQVY Y +    PP       G   +   D+  A   F+ KS+R  FIRKVY I++ Q+++T   +A+  FVEPI+ WV+RN + Y ++ AI IV  + L C  G RRK+P N   L  FTLA S+M   I+   +T  V  A  IT  + ++ITIFA QTKIDFT  SG +L+LS+V L  G     I+A +  +++V+ +Y  + +L+F I+L+ DTQL++GG   Y +SPEDYI  AL LY+DIV +FL++L +F N +
Sbjct:   81 PRPQVYPYGSQLQNPPIYSYGNPGNASLTNPDSDTAHFVFTSKSIRLAFIRKVYAILSLQMVITIGLMALMLFVEPIKLWVQRNKYLYIVAIAIVIVLMVVLGCFTGPRRKFPLNIILLLAFTLAESFMLGVISISKDTRYVAYATVITLAIVVAITIFAFQTKIDFTYLSGGLLILSIVFLAFG-----IFALIMRNRLVNLIYCCIGVLIFSIFLLVDTQLMLGGNHSYSISPEDYIFAALNLYVDIVQIFLMVLGIFSNSD 339

[Close]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Match: SMESG000027408.1 (SMESG000027408.1)

HSP 1 Score: 99.3673 bits (246), Expect = 7.049e-24
Identity = 79/239 (33.05%), Postives = 121/239 (50.63%), Query Frame = 2

Query:  308 MYGGDNFAAFSDKSVRNGFIRKVYLIMTAQL-LVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDF-TMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCIL-------VFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFG 997
            MYG     A S  S+R GF+RKVY I++ QL + T +   +  F E ++ ++K N W  +L   + IV  I +     +R+  P NF  L +FTL  S     I   Y+  AVL++  +T +V +S+TI+  QTK DF T  +G+               G++    G    +    +GL I+       +F + +IYDT + I    + LS E+YI   + LYLDI+N+FL IL + G
Sbjct:   13 MYGAT--VAQSHVSIRLGFLRKVYGILSVQLGMTTVIGCIMMMFQESVRSFLKDNAWILFLCLILNIVVLITMFV---LRKTTPHNFLCLFLFTLIESITVGFIIIQYQVAAVLISLVLTLLVSVSLTIYTFQTKRDFSTWGAGL-------------FAGLVILCFGGIIQLFVKSSGLEIILAIGGAFLFSMLIIYDTWMAI----HRLSAEEYILACIDLYLDIINLFLHILRIVG 229

[Close]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Match: SMESG000014372.1 (SMESG000014372.1)

HSP 1 Score: 78.1814 bits (191), Expect = 9.605e-16
Identity = 64/264 (24.24%), Postives = 124/264 (46.97%), Query Frame = 2

Query:  236 YPPQPQVYNYQATEPQPPYQGAGDMYGGDNF--------AAFSDKSVRNGFIRKVYLIMTAQLLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRRKYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFAMQTKIDFTMCSGMIXXXXXXXXXXXXXCGIIYATMGPSKVVHAVYAGLCILVFGIYLIYDTQLVIGG-RKYELSPEDYIEGALQLYLDIVNMFLIILSLFGN 1000
            Y   PQ+++  +T   P       +YG  N           F  K+ R  FI+ VY ++T Q+L T   I +  FV  I+ W+     F ++   +  +  + +  CP  RRK+P N+  L  FT+ +  +   +  F  +  +  +  + A + I   +F  Q K D T  +G ++VL +V L       I+   +    V+  +Y  + ++++ + L+ +TQL++ G   Y +S  +++   L LYL+ ++  +++  +F N
Sbjct:   68 YARDPQLWSGTSTMTIPGASPRTLVYGLRNADISQDSDDVKFLSKADRYAFIKWVYGLLTIQILFTVFIIVIMCFVNAIKNWLLTQSCFLWVFSLLAFLQILIIGFCPITRRKFPTNYLLLESFTITVGCILGMVTVFMTSKILFYSIVLIAFIIIVSFVFGFQNKYDLTYLTGSLIVLLVVALGF-----IVGLLLIGYDVITMIYCVVGVILYSVMLLVETQLILEGYHVYIISQNEHVFVTLNLYLNAIHSMIMLSGVFCN 326

The following BLAST results are available for this feature:

BLAST of Protein lifeguard 2 vs. Ensembl Human
BLAST of Protein lifeguard 2 vs. Ensembl Celegans
BLAST of Protein lifeguard 2 vs. Ensembl Fly
BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
BLAST of Protein lifeguard 2 vs. Ensembl Mouse
BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
BLAST of Protein lifeguard 2 vs. TrEMBL
BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
BLAST of Protein lifeguard 2 vs. Ensembl Yeast
BLAST of Protein lifeguard 2 vs. Ensembl Nematostella
BLAST of Protein lifeguard 2 vs. Ensembl Medaka
BLAST of Protein lifeguard 2 vs. Planmine SMEST

BLAST of Protein lifeguard 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TMBIM1	8.040e-66	47.58	transmembrane BAX inhibitor motif containing 1 [So...	[more]
TMBIM1	8.040e-66	47.58	transmembrane BAX inhibitor motif containing 1 [So...	[more]
TMBIM1	8.040e-66	47.58	transmembrane BAX inhibitor motif containing 1 [So...	[more]
FAIM2	1.823e-63	42.54	Fas apoptotic inhibitory molecule 2 [Source:HGNC S...	[more]
FAIM2	1.101e-62	46.41	Fas apoptotic inhibitory molecule 2 [Source:HGNC S...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tag-120	1.336e-50	37.80	pep chromosome:WBcel235:V:9706603:9709814:-1 gene:...	[more]
tag-120	1.336e-50	37.80	pep chromosome:WBcel235:V:9707771:9709877:-1 gene:...	[more]
xbx-6	4.861e-46	36.54	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	4.861e-46	36.54	X-BoX promoter element regulated [Source:UniProtK...	[more]
xbx-6	4.861e-46	36.54	X-BoX promoter element regulated [Source:UniProtK...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Lfg	3.363e-66	45.78	gene:FBgn0025692 transcript:FBtr0087813	[more]
Lfg	1.307e-64	47.81	gene:FBgn0025692 transcript:FBtr0332885	[more]
Lfg	1.307e-64	47.81	gene:FBgn0025692 transcript:FBtr0087814	[more]
Nmda1	1.800e-57	40.61	gene:FBgn0013305 transcript:FBtr0332883	[more]
Nmda1	1.800e-57	40.61	gene:FBgn0013305 transcript:FBtr0089878	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grinaa	3.983e-62	44.64	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
tmbim1a	2.659e-59	48.10	transmembrane BAX inhibitor motif containing 1a [S...	[more]
faim2a	2.596e-58	44.25	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
faim2a	2.596e-58	44.25	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
grinab	2.136e-55	41.88	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmbim1	5.469e-69	47.79	transmembrane BAX inhibitor motif containing 1 [So...	[more]
faim2	1.005e-65	38.78	Fas apoptotic inhibitory molecule 2 [Source:NCBI g...	[more]
tmbim1	3.493e-61	45.71	transmembrane BAX inhibitor motif containing 1 [So...	[more]
tmbim1	2.638e-56	43.78	transmembrane BAX inhibitor motif containing 1 [So...	[more]
grina	2.555e-49	43.75	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Tmbim1	3.343e-67	50.00	transmembrane BAX inhibitor motif containing 1 [So...	[more]
Tmbim1	3.343e-67	50.00	transmembrane BAX inhibitor motif containing 1 [So...	[more]
Faim2	2.109e-61	44.76	Fas apoptotic inhibitory molecule 2 [Source:MGI Sy...	[more]
Faim2	3.926e-61	45.08	Fas apoptotic inhibitory molecule 2 [Source:MGI Sy...	[more]
Grina	8.955e-61	44.71	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]

BLAST of Protein lifeguard 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q969X1\|LFG3_HUMAN	3.861e-65	47.58	Protein lifeguard 3 OS=Homo sapiens OX=9606 GN=TMB...	[more]
sp\|Q8BJZ3\|LFG3_MOUSE	4.914e-65	49.15	Protein lifeguard 3 OS=Mus musculus OX=10090 GN=Tm...	[more]
sp\|Q9BWQ8\|LFG2_HUMAN	5.287e-62	46.41	Protein lifeguard 2 OS=Homo sapiens OX=9606 GN=FAI...	[more]
sp\|Q5R4I4\|LFG2_PONAB	7.523e-62	45.99	Protein lifeguard 2 OS=Pongo abelii OX=9601 GN=FAI...	[more]
sp\|O88407\|LFG2_RAT	2.862e-61	43.56	Protein lifeguard 2 OS=Rattus norvegicus OX=10116 ...	[more]

BLAST of Protein lifeguard 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A3R7C8S7	1.983e-95	59.29	Protein lifeguard 3 (Fragment) OS=Clonorchis sinen...	[more]
G7Y2U8	1.489e-94	59.29	Fas apoptotic inhibitory molecule 2 OS=Clonorchis ...	[more]
A0A183LH72	5.729e-94	58.98	Uncharacterized protein OS=Schistosoma margrebowie...	[more]
A0A183QQ07	5.162e-93	57.81	Uncharacterized protein OS=Schistosoma rodhaini OX...	[more]
A0A3Q0KPN6	7.392e-91	57.42	Putative recs1 protein (Responsive to centrifugal ...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
grinab	1.662e-68	47.89	protein lifeguard 1-like [Source:NCBI gene;Acc:103...	[more]
grinab	6.992e-67	47.24	protein lifeguard 1-like [Source:NCBI gene;Acc:103...	[more]
grinaa	4.452e-65	43.62	glutamate ionotropic receptor NMDA type subunit as...	[more]
tmbim1a	4.185e-62	44.73	transmembrane BAX inhibitor motif containing 1 [So...	[more]
tmbim1b	5.410e-61	42.16	protein lifeguard 3-like [Source:NCBI gene;Acc:111...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
faim2a	9.995e-68	50.00	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
faim2a	3.198e-63	46.90	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
grinaa	3.183e-56	44.44	glutamate receptor, ionotropic, N-methyl D-asparta...	[more]
faim2a	2.980e-55	46.98	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]
faim2a	1.896e-38	46.95	Fas apoptotic inhibitory molecule 2a [Source:ZFIN;...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
BXI1	6.419e-14	24.24	Protein involved in apoptosis; variously described...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3


Match Name	E-value	Identity	Description
EDO37574	3.986e-57	48.93	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO49375	4.933e-54	43.98	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO48159	1.908e-25	31.19	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Protein lifeguard 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tmbim1a	3.632e-67	49.36	transmembrane BAX inhibitor motif containing 1 [So...	[more]
grinaa	4.504e-67	47.97	protein lifeguard 1 [Source:NCBI gene;Acc:10116465...	[more]
grinab	9.700e-67	46.59	protein lifeguard 1 [Source:NCBI gene;Acc:10116133...	[more]
faim2b	1.889e-53	38.98	protein lifeguard 2-like [Source:NCBI gene;Acc:101...	[more]
tmbim1b	2.725e-53	44.35	protein lifeguard 3-like [Source:NCBI gene;Acc:101...	[more]

BLAST of Protein lifeguard 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000057144.1	0.000e+0	100.00	SMESG000057144.1	[more]
SMESG000014373.1	2.988e-52	42.80	SMESG000014373.1	[more]
SMESG000014373.1	3.256e-52	42.80	SMESG000014373.1	[more]
SMESG000027408.1	7.049e-24	33.05	SMESG000027408.1	[more]
SMESG000014372.1	9.605e-16	24.24	SMESG000014372.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019535 ID=SMED30019535|Name=Protein lifeguard 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1238bp
GAATTGTTTTAAATAATCAGCAAAATTTATTTTAAATTTGTAAACAGTTA
ATATACTGTCATTTAAATTTTTTAATCTATTTTGTATTTTTAACTGTATG
GCTTCAGCACCTCCCTCTTACGATGATGTAACCAAAAATCCATATGGACC
TCCAGGTGGTTATCCTCAAAACGAGCCACCTTATCCACAACAGCAAGGGC
AATACCAACCATACCCAGGCAACCCAAATACTGTATACCCACCTCAGCCT
CAAGTATATAATTATCAAGCTACTGAACCCCAACCTCCTTATCAAGGAGC
TGGAGATATGTATGGAGGTGATAATTTTGCGGCATTTTCAGATAAGTCAG
TACGAAACGGTTTTATAAGAAAAGTTTATTTAATTATGACAGCCCAATTA
CTTGTAACTTGTTTATTTATCGCTGTTTTTCAATTTGTAGAACCGATTCA
AAAATGGGTTAAAAGAAATCCGTGGTTTTATTATTTGTCTTTTGCTATCT
TCATTGTCACTTATATAGCATTAGTATGCTGTCCAGGCGTTCGTAGAAAA
TATCCTGGCAATTTTTTTGCTTTATCTATTTTTACATTAGCCTTGTCATA
TATGACAGCTACTATAGCCAGCTTCTACGAAACACCAGCTGTATTAGTTG
CTGCGGGAATCACAGCTATTGTTTGTATTAGCATTACAATATTTGCTATG
CAAACAAAAATAGATTTTACAATGTGTAGTGGCATGATTCTTGTATTGTC
TTTGGTTCTGCTTTTAACTGGACTATCCTGTGGGATCATATATGCGACTA
TGGGACCGAGCAAGGTGGTACATGCCGTATATGCTGGATTATGTATTCTT
GTGTTTGGAATATATTTAATCTATGACACCCAATTGGTTATCGGTGGCAG
GAAATATGAACTAAGTCCAGAAGATTATATTGAAGGAGCGTTACAGTTGT
ATTTGGATATCGTTAATATGTTTTTAATAATATTGTCACTATTTGGAAAT
AAGAATTGATTATGGGAGTCCACGAGAATAATTTGGTGTTAGACATTGAT
GACATTTGATTCTTCGGTATTATCTGAGAGTATGGATTTAGACAGTAATA
AGATTTGGATTTTTACTTTATAAAACTGAAATATATGTTTTTGTTATTTG
TTGAGTGTATTGTTGTCATATTATATTTGATGTTTGTTATTCTTGAAAAT
TTGAAGATATTCATAAACACCGAAATAAAATATTTGGG

protein sequence of SMED30019535-orf-1

>SMED30019535-orf-1 ID=SMED30019535-orf-1|Name=SMED30019535-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=304bp
MASAPPSYDDVTKNPYGPPGGYPQNEPPYPQQQGQYQPYPGNPNTVYPPQ
PQVYNYQATEPQPPYQGAGDMYGGDNFAAFSDKSVRNGFIRKVYLIMTAQ
LLVTCLFIAVFQFVEPIQKWVKRNPWFYYLSFAIFIVTYIALVCCPGVRR
KYPGNFFALSIFTLALSYMTATIASFYETPAVLVAAGITAIVCISITIFA
MQTKIDFTMCSGMILVLSLVLLLTGLSCGIIYATMGPSKVVHAVYAGLCI
LVFGIYLIYDTQLVIGGRKYELSPEDYIEGALQLYLDIVNMFLIILSLFG
NKN*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000034	epidermis
PLANA:0000099	neuron
PLANA:0000101	muscle cell
PLANA:0003001	lateral region of the whole animal
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR006214	Bax_inhibitor_1-related

Vocabulary: **cellular component**
Term	Definition
GO:0016020	membrane
GO:0016021	integral component of membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR006214	Bax inhibitor 1-related	PFAM	PF01027	Bax1-I	coord: 88..299 e-value: 1.6E-34 score: 119.5
IPR006214	Bax inhibitor 1-related	PANTHER	PTHR23291	BAX INHIBITOR-RELATED	coord: 16..302
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 1..42
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 27..41
None	No IPR available	PANTHER	PTHR23291:SF81	X-BOX PROMOTER ELEMENT REGULATED	coord: 16..302
None	No IPR available	CDD	cd10428	LFG_like	coord: 79..300 e-value: 1.53552E-96 score: 281.737
None	No IPR available	SUPERFAMILY	SSF81995	beta-sandwich domain of Sec23/24	coord: 11..68
None	No IPR available	TMHMM	TMhelix		coord: 181..200
None	No IPR available	TMHMM	TMhelix		coord: 126..148
None	No IPR available	TMHMM	TMhelix		coord: 155..177
None	No IPR available	TMHMM	TMhelix		coord: 93..111
None	No IPR available	TMHMM	TMhelix		coord: 240..259
None	No IPR available	TMHMM	TMhelix		coord: 213..235