NPHP6
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019531 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 30Note: Hover over icons to view figure legend
Homology
BLAST of NPHP6 vs. Ensembl Human
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 796.193 bits (2055), Expect = 0.000e+0 Identity = 697/2129 (32.74%), Postives = 1212/2129 (56.93%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNI-EYDPV----MQSMARKYESAPQGNNTW---RIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEE---LGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFD-----LETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ TD + + E ++Q++ L + + +N+ DD IM+ VN +VE+WK I+ +D EI + LR L+ + ++++K+NV AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L+R G S+ Q +K ++ LD ++ +E E ++++EL +AL+R K YE G +GL +AV EIK CK Q+++++RE E + +NK + EN LR ++ + +D+ +R K + ++ RA N +L KEIE LE+ERL LKKK+R +A++ G R+ ++G+ D+ + +NI + D + + ++ K S Q N + + E+E E S V A ++++ +L+ N+QL+ + M + L+ IKE + ++ G L P L++L+ A+E++ G FD ++LK ++D L + E R I + Q + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK+ ++ E + ++ + +E +D ++ E++ +L+ L D E+K+ LA+ R+ITVL+VNE +L R+Y+ + E+E+ +R+EN K K+E++ +EA V +++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E +K E++ K LE K++ H +E E+ LG + +++ KS +NS ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K ELT NL+ QK+E+ LRDEL DSVSK ++DA+++R+LELEK E+E K E+ KL+EI++IA Q L QQ SR+KE SLR QL D Q QSDEKSLI KLH+H V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + + LE E ++ + T LKD TK +K + +W K+E LRL+ LK R+ + E+++L ++I E ++ ++E+I + + H+++Q+ W+QRE +LER + + Q E++ AA F++AT G++PDPS PLPNQL+ A+ IK++IR+I + K+L + KE E+ +R E +L R++ INELRLRLPA+ +R + + ++ + KS++ T+ A T++ +Q RL K+E L +Y++LL++ARE+ +KH E++ +L RL +A + + + + T V T+ + E+ +A Q + L ++L + L Q++ E K ++ + + E+E+ +K + +LK L++ + + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+++D+HTR+L ++E + +L+ + L++++ + + L+ L + K+ K+ +K +++QENDEL+ Q++R+ + L+ D + ++ ++ K++ +E NQL+ P K N+K E++ WEEGK+ Q + ++ KL++KE ++ L+KQL+T + +EK ++ +L G +D + I A + RN +LE +I MR + +V +++ ++NR LQ + LE++ ++ SG S ++E+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK EK ++ K + +++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN LK EL LK +GH+L+ Y++K +G +++++ E+LRK+L +E + EK RI + +K+ Q + +L +ESRG Q
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK-IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL----------NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTV--IAKFQNKLKELVEENKQLE---EGMKEILQAIKE--MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD------------IVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST-LKD---TKGAQKVI--NWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEAT--------GSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP-----KSHH----TLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE---NQLEGKVEEVDLKPMKEKNAK----EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLK---TTGMTVD---QVLGIRALESEKELEELKK-----------RNLDLENDI-LYMRAHQALPRDSV----VEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRK-----------LGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQ 2257
BLAST of NPHP6 vs. Ensembl Human
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 791.956 bits (2044), Expect = 0.000e+0 Identity = 695/2131 (32.61%), Postives = 1211/2131 (56.83%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL--QXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNI-EYDPV----MQSMARKYESAPQGNNTW---RIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEE---LGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFD-----LETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ TD + + E ++Q++ L + + +N+ DD IM+ VN +VE+WK I+ +D EI + LR L+ + ++++K+NV AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L+R G S+ Q +K ++ LD ++ +E E ++++EL +AL+R K YE G +GL +AV EIK CK Q+++++RE E + +NK + EN LR ++ + +D+ +R K + ++ RA N +L + IE LE+ERL LKKK+R +A++ G R+ ++G+ D+ + +NI + D + + ++ K S Q N + + E+E E S V A ++++ +L+ N+QL+ + M + L+ IKE + ++ G L P L++L+ A+E++ G FD ++LK ++D L + E R I + Q + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK+ ++ E + ++ + +E +D ++ E++ +L+ L D E+K+ LA+ R+ITVL+VNE +L R+Y+ + E+E+ +R+EN K K+E++ +EA V +++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E +K E++ K LE K++ H +E E+ LG + +++ KS +NS ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K ELT NL+ QK+E+ LRDEL DSVSK ++DA+++R+LELEK E+E K E+ KL+EI++IA Q L QQ SR+KE SLR QL D Q QSDEKSLI KLH+H V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + + LE E ++ + T LKD TK +K + +W K+E LRL+ LK R+ + E+++L ++I E ++ ++E+I + + H+++Q+ W+QRE +LER + + Q E++ AA F++AT G++PDPS PLPNQL+ A+ IK++IR+I + K+L + KE E+ +R E +L R++ INELRLRLPA+ +R + + ++ + KS++ T+ A T++ +Q RL K+E L +Y++LL++ARE+ +KH E++ +L RL +A + + + + T V T+ + E+ +A Q + L ++L + L Q++ E K ++ + + E+E+ +K + +LK L++ + + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+++D+HTR+L ++E + +L+ + L++++ + + L+ L + K+ K+ +K +++QENDEL+ Q++R+ + L+ D + ++ ++ K++ +E NQL+ P K N+K E++ WEEGK+ Q + ++ KL++KE ++ L+KQL+T + +EK ++ +L G +D + I A + RN +LE +I MR + +V +++ ++NR LQ + LE++ ++ SG S ++E+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK EK ++ K + +++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN LK EL LK +GH+L+ Y++K +G +++++ E+LRK+L +E + EK RI + +K+ Q + +L +ESRG Q
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK-IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEASIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL----------NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTV--IAKFQNKLKELVEENKQLE---EGMKEILQAIKE--MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD------------IVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST-LKD---TKGAQKVI--NWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEAT--------GSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP-----KSHH----TLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE---NQLEGKVEEVDLKPMKEKNAK----EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLK---TTGMTVD---QVLGIRALESEKELEELKK-----------RNLDLENDI-LYMRAHQALPRDSV----VEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRK-----------LGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQ 2259
BLAST of NPHP6 vs. Ensembl Human
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 329.717 bits (844), Expect = 1.267e-94 Identity = 266/861 (30.89%), Postives = 477/861 (55.40%), Query Frame = 2
Query: 818 RMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNI-EYDPV----MQSMARKYESAPQGNNT-----WRIKEREM-----------SSELSNAVKERAVKEDE---------IAKLMTRNRQLQTEN----DAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEE---LGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNT 3277
++Q++ L + + +N+ DD IM+ VN +VE+WK I+ +D EI + LR L+ + ++++K+NV AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L+R G S+ Q +K ++ LD ++ +E E ++++EL +AL+R K YE G +GL +AV EIK CK Q+++++RE E + +NK + EN LR ++ + +D+ +R K + ++ RA N +L KEIE LE+ERL LKKK+R +A++ G R+ ++G+ D+ + +NI + D + + ++ K S Q N + IKE E S N R + E E IAK + ++L EN + M + L+ IKE + ++ G L P L++L+ A+E++ G FD ++LK ++D L + E R I + Q + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK+ ++ E + ++ + +E +D ++ E++ +L+ L D E+K+ LA+ R+ITVL+VNE +L R+Y+ + E+E+ +R+EN K K+E++ +EA V +++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E +K E++ K LE K++ H +E E+ LG + +++ KS +NS ++S+SKK+ LEMK++NE++RA+H +MYE+++ +
Sbjct: 4 QLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK-IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL----------NLTENISQGDRISERKLDLLSLKNMSEAQSKNEIIAQEFLIKEAECRNADIELEHHRSQAEQNEFLSRELIEKERDLERSRTVIAKFQNKLKELVEENKQLEEGMKEILQAIKE--MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD------------IVSISKKITMLEMKELNERQRAEHCQKMYEHLRTS 839
BLAST of NPHP6 vs. Ensembl Human
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 302.753 bits (774), Expect = 2.084e-84 Identity = 285/969 (29.41%), Postives = 528/969 (54.49%), Query Frame = 2
Query: 4058 SWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRI-KNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRN-------PAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
+W K+E LRL+ LK R+ + E+++L ++I E ++ ++E+I + + H+++Q+ W+QRE +LER + + Q E++ AA F++ATG+ +PDPS PLPNQL+ A+ IK++IR+I + K+L + KE E+ +R E +L R++ INELRLRLPA+ +R + + ++ + KS++ T+ A T++ +Q RL K+E L +Y++LL++ARE+ +KH E++ +L RL +A + + + + T V T+ + E+ +A Q + L ++L + L Q++ E K ++ + + E+E+ +K + +LK L++ + + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+++D+HTR+L ++E + +L+ + L++++ + + L+ L + K+ K+ +K +++QENDEL+ Q++R+ L+ D + ++ ++ K++ +E NQL+ P K N+K E++ WEEGK+ Q + ++ KL++KE ++ L+KQL+T + +EK ++ +L G +D + I A +++L++RN +LE +I MR + +V +++ ++NR LQ + LE++ ++ SG S ++E+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK EK ++ K + +++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN LK EL LK +GH+L+ Y++K +G +++++ E+LRK+L +E + EK RI + +K+ Q + +L +ESRG Q
Sbjct: 25 NWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGS--------IPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP-----KSHH----TLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE---NQLEGKVEEVDLKPMKEKNAK----EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLK---TTGMTVD---QVLGIRA-----------LESEKELEELKKRNLDLENDI-LYMRAHQALPRDSV----VEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRK-----------LGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQ 936
BLAST of NPHP6 vs. Ensembl Human
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 169.474 bits (428), Expect = 6.805e-42 Identity = 175/596 (29.36%), Postives = 317/596 (53.19%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL--QXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNI-EYDPV----MQSMARKYESAPQGNNTW---RIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQA 2383
L A EKI +QEM ++NLE + E+E++T EY MK+ TD + + E ++Q++ L + + +N+ DD IM+ VN +VE+WK I+ +D EI + LR L+ + ++++K+NV AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L+R G S+ Q +K ++ LD ++ +E E ++++EL +AL+R K YE G +GL +AV EIK CK Q+++++RE E + +NK + EN LR ++ + +D+ +R K + ++ RA N +L + IE LE+ERL LKKK+R +A++ G R+ ++G+ D+ + +NI + D + + ++ K S Q N + + E+E E S V A ++++ +L+ N+QL+ + M + L+ IKE + ++ G L P L++L+ A+E++ G FD ++LK ++D L + E R I + Q + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK-IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEASIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL----------NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTV--IAKFQNKLKELVEENKQLE---EGMKEILQAIKE--MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKV 799
BLAST of NPHP6 vs. Ensembl Zebrafish
Match: cep290 (centrosomal protein 290 [Source:NCBI gene;Acc:560588]) HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0 Identity = 742/2337 (31.75%), Postives = 1292/2337 (55.28%), Query Frame = 2
Query: 29 SSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDL-----EEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVR-EKRNWEMEKESMNQEIRELKSKYNSLTEDNDK-------KEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXX-XXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX----XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAV-DSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSV--LESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNG--QLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHT-------RDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEE-NNQLKRNPA-KSANSKQD--SQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG 6904
+++DW ++ + + L D+I LMV D+ DD++K+ + F I+Q ++ K +E K E + E+A ++ + + + + A + G D + +R E R E E +E+ +L+ + + N++ EE K ++EI+ L N +L ++EF R+ Q ++ + + + + + L +L Q +L +A++ L E +HL++NLE + E+E++T EY MK TD + + ++Q+ L +Q+ R + DD +M VN +VE+WK ++ +D EI + LR L+ + ++S+K+N+ AL + V+ER+ ++K LS+Q+ +E N LIE LK+ L++ G SS HQ RR+++L L E+ + E E D+++EL D L R ++YE G GL A++EIK CK Q++V++RE E ++ +N+ L EN LR +L + E+LD+ +RR K + + +A N VL KEIE+LE+ERL LK+++R L + G+ S + L++S +E PV + + S + R ER + ELSN KE ++ E + + ++ EN + +++I + + + GV + P L++L+ A+E + G+FD ++L+T++D L +E++ + QL ++K+ + M+ M + + LPE ++ ++++ I ALN++ + +LQE K ++++ AL+ Y+RKFA +RH+QGLLY+++ E++ +++E ++ +E R D +I E++ +L+TL +D SE++R +A+ R+I VL+VNE LTRRY+ + E+EQ +R+EN KLK + Q++A VT+R+GY +RFKE A +K+ LQK LD SVP ++ + ++ E+T KYRN L+K N L+ + S+ +E+E ++ +++ K LE K++ H LE E +I +T K+ AV +S ++S+S+++ TLEMK++NE++RA+HA +MYE+++N+ + E+RN ELE K ELT NLE Q+IERELRDEL DSVSK I+DA+++R+ ELEK E + E+ KL+E++++A MQ +AL +Q SREKE SLR+Q+ D Q +SDEK+LI KLH+HIV LQ+SET+A+ +L+ + ++LEAQ LR EQ DE+ Q L+ R +G R +HLR TI +LR QFSG++PL++ E+F++T++ L ED+ ++ ++ Q+T + E + Q + + L++ +AT ++ K + W K+E +RL ++ R+ + R E+++L++ + QE ++ ++E++ + +++QL+W+QRE +LER + + E Q EV+ A F++AT G+LPDP+ PL NQLD A+ IK+H+R I + + K L + KE E + E +L R++ INELRLRLPA+ +R + + +S ++ + + T+ A T++ LQ RL K+E L +Y+ LL +AR++ ++H EE++ L ++L R + T V TS E+ +A Q + L +L + +L Q+Q + + + E K ++ L + L+ +L + E ++ + E+ K RSP+ MKN + +L QL KEKQL+ L L +++ +T Q+ + + N+Q+++DK T RDL+ EL+ +D + R+A+A + ++ +L+ L D + + KL+++K LE+ +EL+ ++QR+ + L+ +D +DA++ K+R +E E + + PA K + K+D S+E+V WEEGK+ Q DK++ L++KE ++ + +KQL T + R+ +EK +++ +L G G D + A +++L +RN ELE++I ++M+ + + A+++ RNR L+ + +E RL++ SG S ++E QKE +RL+ +NLEL+F+ E A K++PRLK++V+D K+ +LK EK +E + N +++ G SGK+ ELEK IG MKKVVEK QRENE LK V + EQ+ L ++ LK E LK + +L R ++K +G+ +++ + E+LRK++ +EAE EK R+ + +KL+ + + +L +++S+G
Sbjct: 3 AAADWRLLMGMDPEDLGDEDEKICDLI--LMVKPRDL-KADDSEKMIQLFRISQTLLRMKLDEIKCAYEVVDSAGAEQARIENELKAKVLKLESELEMAQRVMGGGDKHFLRDEIRQLESHLERKEKEVTQLEKEMGKERKSNEELALRAEEAEEKNRKLKREIKQLTRKNEQLQQDIEFYRKEAEQRESLQTKEESNEIQRRLTKANQQLYQCMEELQHAEDMAANLRSENEHLQKNLEESVKEMEKMTDEYNKMKIAVQQTDAIMDQLRKDRDHAKLQVRELTDQIQARVEEDDPVMAAVNAKVEEWKSVLSGKDLEILEYQQMIRDLREKLRTAQMDSDKSNIIALQQAVQERDNQIKMLSEQVEQYTTEMERNAMLIEELKRPLKKDKGHSSDHQ-RRLEDLSAKLQVAERKVLEAQRAAQLAERDARDKDKELNDTLSRIRLYESGTDGLEAAISEIKECKNQIRVRDREIEGMIKEINQLEMKINNLLDENEDLRERLGLNPKEELDLSEFRRSKILKQRQYKAENQVLLKEIERLEEERLELKQRIRALVKDKGVTVVSNSL-------------LDNS---VEEKPVR---SLRPSSGSTDDEIKRKNER-LQKELSNKEKELELRRSESTQFKAKLNEMLNENKQLEQGMKEILQAIQDTQKKTPTSTGVSI---PSLERLVNALEMKYSEGKFDASLHLRTQVDQLTGRNEELRQEMKTAREEAANTLSQLTKANEKIARLESEMESMSKSTGSSIPHKTLALPEEMTPTSAEAINALNEYTVQLLQEIKNKGDSIEQLGSALEEYKRKFAVIRHQQGLLYKEHQSERESWQKERDSFAELKSKLEEQREVDAVKIKEYNHLLETLEKDPSEIRREMAETGRKIVVLRVNEKCLTRRYTTLLELEQHLRKENAKLKEDFTQMQAAVTERIGYLQRFKEMAAFKMASLQKSLDVSVPASELERANKQYTELTIKYRNLLQKDNHLVQKTTSLEHLETENMSLRERIDSINKELEISKEKLHTLEQAFE----------NISTTGGEIIMDKATKAVANSEIVSVSRRITTLEMKELNERQRAEHAQKMYEHLRNSLKQVEERNFELETKFAELTKLNLEAQRIERELRDELADSVSKHISDADRKRITELEKTEANLRIEVSKLREVSDVAKMQVSALDARQQSREKEVESLRRQVLDYQAESDEKALIAKLHQHIVALQLSETTAISRLEATNTRLQKLEAQKLRDEQKLDEQQQALWHARQEGHQRARHLRHTIQALRRQFSGALPLAQQEKFSNTMLHLQEDRARVREDAQITEEERRKAEGKAQELELKLKG---LEELIATLKDAKGAQKVSEWHKKLEDVRLLEMRQSRELNTQREEIKYLKNCVAEQERTISGLEEELVQQNNLLEERQLIWDQREVQLERQLDSYEKQQNEVLNTAQKFEEAT--------GSLPDPNQPLANQLDYALGKIKEHVRTILETKTTCKILEEKLKEKEAALWSSEQNVLSRDKVINELRLRLPAAAEREKLLADLS----------KQEDSESQPTLKVAHQTINNLQGRLDQKEEVLKKYQNLLGKARQEQEEIAKRHEEEVRALHQKLDVYMDTSLDRFKQTALELIKKPTITVPTSKHLVRLAEMEQTVAEQDNSLSSLSQKLKIVTQELDQQRQVTAAQAMEHAADMARLEDKHAAQMKGLSQEAEELRAQLIQMEKELHYLRTELEAQKEANVRSPSNTMKNLVERLKNQLALKEKQLKALSKALLELRAELTSQAEQQIITNAAQKEEALNVQQIVDKQTKELRACVRDLNEELQLAKDGV-------RAAKARENSLKEDLETLNKDLQRSQKSQNKLQSEKEALEEHLNELKKKIQRLSSGLQAQVESDGPT--VDALQKKIRKLEHELDRKSISEPADKRSTLKEDKSSKEEVVRWEEGKKWQARVDKMRNVLKEKEREVDSQAKQLATMKELYSRLEQEKVSLQKKLK---GRGVTAD--------------QVVGARTLEADKEIEELHKRNAELEQQI-KVMKQQQA----LPRDAAMEDITNRNRYLEERLYSMESRLSKEPPSRPSTSGRGSDTPSQREHEFQKENLRLSTENLELRFQLEQANKDLPRLKDQVSDLKEMCSVLKKEKAEVEKRLN-----------HLRGSGRSGKTIPELEKTIGLMKKVVEKVQRENENLKRTSEVNVQEQLATLERDHEKLKSEYEKLKGKQEEQLNSRLESKTKGIEKIMMENERLRKEIKKEAEAAEKLRVAKASLEVANEKLKAELEETHQRLLLAQSKG 2239
BLAST of NPHP6 vs. Ensembl Zebrafish
Match: cep290 (centrosomal protein 290 [Source:NCBI gene;Acc:560588]) HSP 1 Score: 848.195 bits (2190), Expect = 0.000e+0 Identity = 742/2337 (31.75%), Postives = 1292/2337 (55.28%), Query Frame = 2
Query: 29 SSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDL-----EEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVR-EKRNWEMEKESMNQEIRELKSKYNSLTEDNDK-------KEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXX-XXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX----XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAV-DSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSV--LESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNG--QLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHT-------RDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEE-NNQLKRNPA-KSANSKQD--SQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG 6904
+++DW ++ + + L D+I LMV D+ DD++K+ + F I+Q ++ K +E K E + E+A ++ + + + + A + G D + +R E R E E +E+ +L+ + + N++ EE K ++EI+ L N +L ++EF R+ Q ++ + + + + + L +L Q +L +A++ L E +HL++NLE + E+E++T EY MK TD + + ++Q+ L +Q+ R + DD +M VN +VE+WK ++ +D EI + LR L+ + ++S+K+N+ AL + V+ER+ ++K LS+Q+ +E N LIE LK+ L++ G SS HQ RR+++L L E+ + E E D+++EL D L R ++YE G GL A++EIK CK Q++V++RE E ++ +N+ L EN LR +L + E+LD+ +RR K + + +A N VL KEIE+LE+ERL LK+++R L + G+ S + L++S +E PV + + S + R ER + ELSN KE ++ E + + ++ EN + +++I + + + GV + P L++L+ A+E + G+FD ++L+T++D L +E++ + QL ++K+ + M+ M + + LPE ++ ++++ I ALN++ + +LQE K ++++ AL+ Y+RKFA +RH+QGLLY+++ E++ +++E ++ +E R D +I E++ +L+TL +D SE++R +A+ R+I VL+VNE LTRRY+ + E+EQ +R+EN KLK + Q++A VT+R+GY +RFKE A +K+ LQK LD SVP ++ + ++ E+T KYRN L+K N L+ + S+ +E+E ++ +++ K LE K++ H LE E +I +T K+ AV +S ++S+S+++ TLEMK++NE++RA+HA +MYE+++N+ + E+RN ELE K ELT NLE Q+IERELRDEL DSVSK I+DA+++R+ ELEK E + E+ KL+E++++A MQ +AL +Q SREKE SLR+Q+ D Q +SDEK+LI KLH+HIV LQ+SET+A+ +L+ + ++LEAQ LR EQ DE+ Q L+ R +G R +HLR TI +LR QFSG++PL++ E+F++T++ L ED+ ++ ++ Q+T + E + Q + + L++ +AT ++ K + W K+E +RL ++ R+ + R E+++L++ + QE ++ ++E++ + +++QL+W+QRE +LER + + E Q EV+ A F++AT G+LPDP+ PL NQLD A+ IK+H+R I + + K L + KE E + E +L R++ INELRLRLPA+ +R + + +S ++ + + T+ A T++ LQ RL K+E L +Y+ LL +AR++ ++H EE++ L ++L R + T V TS E+ +A Q + L +L + +L Q+Q + + + E K ++ L + L+ +L + E ++ + E+ K RSP+ MKN + +L QL KEKQL+ L L +++ +T Q+ + + N+Q+++DK T RDL+ EL+ +D + R+A+A + ++ +L+ L D + + KL+++K LE+ +EL+ ++QR+ + L+ +D +DA++ K+R +E E + + PA K + K+D S+E+V WEEGK+ Q DK++ L++KE ++ + +KQL T + R+ +EK +++ +L G G D + A +++L +RN ELE++I ++M+ + + A+++ RNR L+ + +E RL++ SG S ++E QKE +RL+ +NLEL+F+ E A K++PRLK++V+D K+ +LK EK +E + N +++ G SGK+ ELEK IG MKKVVEK QRENE LK V + EQ+ L ++ LK E LK + +L R ++K +G+ +++ + E+LRK++ +EAE EK R+ + +KL+ + + +L +++S+G
Sbjct: 3 AAADWRLLMGMDPEDLGDEDEKICDLI--LMVKPRDL-KADDSEKMIQLFRISQTLLRMKLDEIKCAYEVVDSAGAEQARIENELKAKVLKLESELEMAQRVMGGGDKHFLRDEIRQLESHLERKEKEVTQLEKEMGKERKSNEELALRAEEAEEKNRKLKREIKQLTRKNEQLQQDIEFYRKEAEQRESLQTKEESNEIQRRLTKANQQLYQCMEELQHAEDMAANLRSENEHLQKNLEESVKEMEKMTDEYNKMKIAVQQTDAIMDQLRKDRDHAKLQVRELTDQIQARVEEDDPVMAAVNAKVEEWKSVLSGKDLEILEYQQMIRDLREKLRTAQMDSDKSNIIALQQAVQERDNQIKMLSEQVEQYTTEMERNAMLIEELKRPLKKDKGHSSDHQ-RRLEDLSAKLQVAERKVLEAQRAAQLAERDARDKDKELNDTLSRIRLYESGTDGLEAAISEIKECKNQIRVRDREIEGMIKEINQLEMKINNLLDENEDLRERLGLNPKEELDLSEFRRSKILKQRQYKAENQVLLKEIERLEEERLELKQRIRALVKDKGVTVVSNSL-------------LDNS---VEEKPVR---SLRPSSGSTDDEIKRKNER-LQKELSNKEKELELRRSESTQFKAKLNEMLNENKQLEQGMKEILQAIQDTQKKTPTSTGVSI---PSLERLVNALEMKYSEGKFDASLHLRTQVDQLTGRNEELRQEMKTAREEAANTLSQLTKANEKIARLESEMESMSKSTGSSIPHKTLALPEEMTPTSAEAINALNEYTVQLLQEIKNKGDSIEQLGSALEEYKRKFAVIRHQQGLLYKEHQSERESWQKERDSFAELKSKLEEQREVDAVKIKEYNHLLETLEKDPSEIRREMAETGRKIVVLRVNEKCLTRRYTTLLELEQHLRKENAKLKEDFTQMQAAVTERIGYLQRFKEMAAFKMASLQKSLDVSVPASELERANKQYTELTIKYRNLLQKDNHLVQKTTSLEHLETENMSLRERIDSINKELEISKEKLHTLEQAFE----------NISTTGGEIIMDKATKAVANSEIVSVSRRITTLEMKELNERQRAEHAQKMYEHLRNSLKQVEERNFELETKFAELTKLNLEAQRIERELRDELADSVSKHISDADRKRITELEKTEANLRIEVSKLREVSDVAKMQVSALDARQQSREKEVESLRRQVLDYQAESDEKALIAKLHQHIVALQLSETTAISRLEATNTRLQKLEAQKLRDEQKLDEQQQALWHARQEGHQRARHLRHTIQALRRQFSGALPLAQQEKFSNTMLHLQEDRARVREDAQITEEERRKAEGKAQELELKLKG---LEELIATLKDAKGAQKVSEWHKKLEDVRLLEMRQSRELNTQREEIKYLKNCVAEQERTISGLEEELVQQNNLLEERQLIWDQREVQLERQLDSYEKQQNEVLNTAQKFEEAT--------GSLPDPNQPLANQLDYALGKIKEHVRTILETKTTCKILEEKLKEKEAALWSSEQNVLSRDKVINELRLRLPAAAEREKLLADLS----------KQEDSESQPTLKVAHQTINNLQGRLDQKEEVLKKYQNLLGKARQEQEEIAKRHEEEVRALHQKLDVYMDTSLDRFKQTALELIKKPTITVPTSKHLVRLAEMEQTVAEQDNSLSSLSQKLKIVTQELDQQRQVTAAQAMEHAADMARLEDKHAAQMKGLSQEAEELRAQLIQMEKELHYLRTELEAQKEANVRSPSNTMKNLVERLKNQLALKEKQLKALSKALLELRAELTSQAEQQIITNAAQKEEALNVQQIVDKQTKELRACVRDLNEELQLAKDGV-------RAAKARENSLKEDLETLNKDLQRSQKSQNKLQSEKEALEEHLNELKKKIQRLSSGLQAQVESDGPT--VDALQKKIRKLEHELDRKSISEPADKRSTLKEDKSSKEEVVRWEEGKKWQARVDKMRNVLKEKEREVDSQAKQLATMKELYSRLEQEKVSLQKKLK---GRGVTAD--------------QVVGARTLEADKEIEELHKRNAELEQQI-KVMKQQQA----LPRDAAMEDITNRNRYLEERLYSMESRLSKEPPSRPSTSGRGSDTPSQREHEFQKENLRLSTENLELRFQLEQANKDLPRLKDQVSDLKEMCSVLKKEKAEVEKRLN-----------HLRGSGRSGKTIPELEKTIGLMKKVVEKVQRENENLKRTSEVNVQEQLATLERDHEKLKSEYEKLKGKQEEQLNSRLESKTKGIEKIMMENERLRKEIKKEAEAAEKLRVAKASLEVANEKLKAELEETHQRLLLAQSKG 2239
BLAST of NPHP6 vs. Ensembl Xenopus
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 811.216 bits (2094), Expect = 0.000e+0 Identity = 729/2252 (32.37%), Postives = 1271/2252 (56.44%), Query Frame = 2
Query: 689 LKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGH-QMRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNN---TWRIKERE--------MSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNL-EERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEA---PASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAK-----FDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQL-----SIQKQKMETTDKINQ-----SRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQEL-------DAMKIKLRLIEEE----NNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-----EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADL-ESKLAISESRGRQ------------NVSRIAN---KELQDENRKLSSIIANLQSQLKDK--------------HNQN------PDSSKVEE--------LKLLYNKATERVSFLEKQLQSFSEQFGVAIDLGY*SGDY 7156
L ++LE + E+E++T EY MK +D + E R+Q++ L EQ+ +N+ DD +M VN +V++WK I+ +D EI ++ LR L+ + ++++K++V AL + ++ER +K L+++L +E N IE LK L+ T G SGH ++++ +EL ML+ E+ ++E+ ER+ K+ E+ ++++EL +AL R + YE G +GL EAV+EIK K Q++++++E E ++++NK + ++ EN L+ +L + +D+ ++ KA ++++ RA N VL KE+E LE+ER+ LKK++R LA++ G RA G+ A D+ + + E S + + ++ A +G N + ++ E+E +++EL + +KE + ED+ + L+ + AL+ ++++ TRN A ++ P L++L+ A+E+R G FD I+LK ++D L + E R I ++ L+ M+ G N+ + I LP+ +S +++ + +LN++++ +LQE KEQ++ K + AL+ Y+RKFA +RH+ GLLY++Y E++ +++E++ L+ +E + D +I E+ +LD L D E+K+++A+ R++TVL+VNE LTRRY+ + EMEQ +R++N KLK+++ +EA V +R+GY +R+KE A +K+ LQ+ LD+SVP ++ +++E+T KYR+ L+K N+L+ R + +E E + +K K LE K++ + LE LE + PA +++ K+ +N + ++S+SKK+ LEMK++NE++RA+H+ +MYE+++ T + E+RN ELE K ELT NLE QK+E+ LRD+L +SVSK ++DA+++R++ELEK E E K E+ KL+ +++IA MQ +AL +Q SREKE S+R+Q+ D Q QSDEK+LI KLH+ IV LQ+SE++A+ KL+ +++EA LR EQ D+KDQ LY R++GR R KHLR+T++SLR QFSG++PL++ E+F+ T+++L DK+K E++ + + +E E ++ + T LKDA R + V E W K+E LRL+ LK R+ + E+++L ++I QE ++ ++ED+ + + H+++Q+ W+QRE ELER + E+ Q EV+ AA F++AT G +PD + PLP QL+ A+ IK+H++ + + ++ + L + KE ++ +R E +L R+R INELRL+LPA+ + + S LN K + + + A T++ +Q RL K+E L +Y+ LL +ARE+ +KH E++K L ++L+ + + M ++ N +R LA +T + + LA + +QL ++KQK T K+N+ +RL+E I + LK + +L+ ++ E E +I + N E+ K TR+P MKN + +L Q+ KEKQ Q L L ++ +T Q+ + + N+Q+++DK T+DL +E +Q L+ + L+++++ + + E + L D KE KL+ DK ++E++N+EL+ K +++L+ N K +L + ++ +++ +E E + + +R P + S S+E++ WEE K+ Q + ++ KL+DKE ++ +L+KQL T + +EK ++ +L + G +D + A + V++LR++N ELE EI + + A DS ++++ LK NR LQ ++ LER+L+Q ++ T ++ + ++KE ++L +N+EL+F E A K++PRLK+++ + K+ DLLK EK E K +++++ G SGK+ ELEK I MK+VVE+ Q+ENE LK+APG++ NE++ L EN LKLE+ L+ VG +L+ RY+AK +G+ +++++ ++LRK+L E E EK RI + + +KL + DL E+++ I+E G Q VS++ KEL+ E +K + I +L+ LK+ N+N P+ +K EE L+L N+ + LE QL+ + ++ GV+ G+ GDY
Sbjct: 139 LTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSIMDRLRKEKEQHRLQVQELAEQLKAKNEEDDPVMRAVNAKVDEWKIILASKDEEISDYQKKIVDLREKLKIAQLDADKSSVLALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQLQ-TEKGVSGHIEIKQAEELVGMLNILEERVKES-ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKELKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYRAENQVLLKEVECLEEERIRLKKQIRKLAQEKGKRAACLGLTADDLNLSVDSPEDHKSKKKKPSNSIVLDHA-------EGMNEHLSKQLSEKEQELERYKTITAELKSKLKE--ISEDK--------KHLEQIPKDIFQALKDVEKD-HTRNGEA----TIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELKESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYILHLLQEVESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLENQKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDNGKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDMLQKDNLLVQRTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKATKAITN------------NEIVSISKKITMLEMKELNERQRAEHSQKMYEHLRTTLTQLEERNFELETKFAELTKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSALASRQQSREKEVESMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLRKMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLAQQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHSVELELKLKGLEELIST-LKDA----RGAQKVTE-WHRKIEELRLQDLKLSRELSQKKEEIKYLNNMISEQERTISILEEDLVQQGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEAT--------GEVPDSNLPLPEQLEIALRKIKEHVKAVVETKSVCRTLEEKLKEKDSLLRTAENNILSRDRVINELRLQLPAT---------AAKETLLSNLNQIKEDSEQHQALKVAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHAEDLKELHQKLNLYSDTSINNFKEAAKEFMKKPSLQIPSSA---NLIR--LAEMEQTVAEQENSLASLSNQLRKATSELEKQKQITIAKVNEFENSKTRLEEKHIVEIKK---LKNDAEDLRARIAETEKEINYLNTELEAQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLTLRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENALIEEAENLNQDLRGKEKALSKLQKDKDEMERDNEELK------KRIKDLTINFQGKVDLHNKHNTSEDLQRRIKKLEAELAKKSEEAERKPVRDDKS---SKEEIIRWEESKKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSR---GVTVD--------------QVVGARTAESEREVEELRKKNQELENEIQHMKTKQALPRDS-VIDDLHLK-----NRFLQEKLQALERQLSQENTSRPSTSGLGSDDQTRELEKENLKLTSENVELQFHLEQANKDLPRLKDQIENLKEMCDLLKKEKIEAERK-----------VASVRGSGRSGKTVPELEKTIALMKRVVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIAENDRLRKELKTETETSEKLRIAKRNLEVIKEKLAR---DLEEARMNIAERSGPQLEGTQGKAWKSTVVSKMFENKIKELESELKKKNDGIVDLKKLLKEATERELKTEKIVGNLKNENELLKNFPEEAKTEEGLARDFQILRLANNRLQNEKAELEHQLEIYRKKSGVS---GH--GDY 2272
BLAST of NPHP6 vs. Ensembl Xenopus
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 804.283 bits (2076), Expect = 0.000e+0 Identity = 725/2268 (31.97%), Postives = 1265/2268 (55.78%), Query Frame = 2
Query: 689 LKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGH-QMRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNL-EERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEA---PASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAK-----FDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQL-----SIQKQKMETTDKINQ-----SRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQEL-------DAMKIKLRLIEEE----NNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-----EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADL-ESKLAISESRGRQ------------NVSRIAN---KELQDENRKLSSIIANLQSQLKDK--------------HNQN------PDSSKVEE------------------------------------------LKLLYNKATERVSFLEKQLQSFSEQFGVAIDL 7135
L ++LE + E+E++T EY MK +D + E R+Q++ L EQ+ +N+ DD +M VN +V++WK I+ +D EI ++ LR L+ + ++++K++V AL + ++ER +K L+++L +E N IE LK L+ T G SGH ++++ +EL ML+ E+ ++E+ ER+ K+ E+ ++++EL +AL R + YE G +GL EAV+EIK K Q++++++E E ++++NK + ++ EN L+ +L + +D+ ++ KA ++++ RA N VL KE+E LE+ER+ LKK++R LA++ G RA +M Y + + M + + + ++++ Q ++ +++EL + +KE + ED+ + L+ + AL+ ++++ TRN A ++ P L++L+ A+E+R G FD I+LK ++D L + E R I ++ L+ M+ G N+ + I LP+ +S +++ + +LN++++ +LQE KEQ++ K + AL+ Y+RKFA +RH+ GLLY++Y E++ +++E++ L+ +E + D +I E+ +LD L D E+K+++A+ R++TVL+VNE LTRRY+ + EMEQ +R++N KLK+++ +EA V +R+GY +R+KE A +K+ LQ+ LD+SVP ++ +++E+T KYR+ L+K N+L+ R + +E E + +K K LE K++ + LE LE + PA +++ K+ +N + ++S+SKK+ LEMK++NE++RA+H+ +MYE+++ T + E+RN ELE K ELT NLE QK+E+ LRD+L +SVSK ++DA+++R++ELEK E E K E+ KL+ +++IA MQ +AL +Q SREKE S+R+Q+ D Q QSDEK+LI KLH+ IV LQ+SE++A+ KL+ +++EA LR EQ D+KDQ LY R++GR R KHLR+T++SLR QFSG++PL++ E+F+ T+++L DK+K E++ + + +E E ++ + T LKDA R + V E W K+E LRL+ LK R+ + E+++L ++I QE ++ ++ED+ + + H+++Q+ W+QRE ELER + E+ Q EV+ AA F++AT G +PD + PLP QL+ A+ IK+H++ + + ++ + L + KE ++ +R E +L R+R INELRL+LPA+ + + S LN K + + + A T++ +Q RL K+E L +Y+ LL +ARE+ +KH E++K L ++L+ + ++ + + R N +R LA +T + + LA + +QL ++KQK T K+N+ +RL+E I + LK + +L+ ++ E E +I + N E+ K TR+P MKN + +L Q+ KEKQ Q L L ++ +T Q+ + + N+Q+++DK T+DL +E +Q L+ + L+++++ + + E + L D KE KL+ DK ++E++N+EL+ K +++L+ N K +L + ++ +++ +E E + + +R P + S S+E++ WEE K+ Q + ++ KL+DKE ++ +L+KQL T + +EK ++ +L + G +D + A + V++LR++N ELE EI + + A DS ++++ LK NR LQ ++ LER+L+Q ++ T ++ + ++KE ++L +N+EL+F E A K++PRLK+++ + K+ DLLK EK E K +++++ G SGK+ ELEK I MK+VVE+ Q+ENE LK+APG++ NE++ L EN LKLE+ L+ VG +L+ RY+AK +G+ +++++ ++LRK+L E E EK RI + + +KL + DL E+++ I+E G Q VS++ KEL+ E +K + I +L+ LK+ N+N P+ +K EE LK YN+ ++ LE++L++ SEQFGV ID
Sbjct: 139 LTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSIMDRLRKEKEQHRLQVQELAEQLKAKNEEDDPVMRAVNAKVDEWKIILASKDEEISDYQKKIVDLREKLKIAQLDADKSSVLALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQLQ-TEKGVSGHIEIKQAEELVGMLNILEERVKES-ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKELKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYRAENQVLLKEVECLEEERIRLKKQIRKLAQEKGKRA---------LM--YNFWHMLTHM-TLHFFFKNEHLSKQLSEKEQELERYKT----ITAELKSKLKE--ISEDK--------KHLEQIPKDIFQALKDVEKD-HTRNGEA----TIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELKESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYILHLLQEVESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLENQKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDNGKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDMLQKDNLLVQRTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKATKAITN------------NEIVSISKKITMLEMKELNERQRAEHSQKMYEHLRTTLTQLEERNFELETKFAELTKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSALASRQQSREKEVESMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLRKMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLAQQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHSVELELKLKGLEELIST-LKDA----RGAQKVTE-WHRKIEELRLQDLKLSRELSQKKEEIKYLNNMISEQERTISILEEDLVQQGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEAT--------GEVPDSNLPLPEQLEIALRKIKEHVKAVVETKSVCRTLEEKLKEKDSLLRTAENNILSRDRVINELRLQLPAT---------AAKETLLSNLNQIKEDSEQHQALKVAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHAEDLKELHQKLNLYSDTSINNFKEAAKVSILMVFFF---KKRHANLIR--LAEMEQTVAEQENSLASLSNQLRKATSELEKQKQITIAKVNEFENSKTRLEEKHIVEIKK---LKNDAEDLRARIAETEKEINYLNTELEAQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLTLRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENALIEEAENLNQDLRGKEKALSKLQKDKDEMERDNEELK------KRIKDLTINFQGKVDLHNKHNTSEDLQRRIKKLEAELAKKSEEAERKPVRDDKS---SKEEIIRWEESKKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSR---GVTVD--------------QVVGARTAESEREVEELRKKNQELENEIQHMKTKQALPRDS-VIDDLHLK-----NRFLQEKLQALERQLSQENTSRPSTSGLGSDDQTRELEKENLKLTSENVELQFHLEQANKDLPRLKDQIENLKEMCDLLKKEKIEAERK-----------VASVRGSGRSGKTVPELEKTIALMKRVVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIAENDRLRKELKTETETSEKLRIAKRNLEVIKEKLAR---DLEEARMNIAERSGPQLEGTQGKAWKSTVVSKMFENKIKELESELKKKNDGIVDLKKLLKEATERELKTEKIVGNLKNENELLKNFPEEAKTEEEFIINMVNIINSKVFSILQEEIKNLKKELQNFDPTFFEEIEDLKYNYNEEVKKNIILEEKLKALSEQFGVHIDF 2284
BLAST of NPHP6 vs. Ensembl Xenopus
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 789.26 bits (2037), Expect = 0.000e+0 Identity = 702/2165 (32.42%), Postives = 1228/2165 (56.72%), Query Frame = 2
Query: 689 LKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNL-EERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEA---PASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAK-----FDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQL-----SIQKQKMETTDKINQ-----SRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLR-NLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-----EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLK-------QMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATER 7072
L ++LE + E+E++T EY MK +D + E R+Q++ L EQ+ +N+ DD +M VN +V++WK I+ +D EI ++ LR L+ + ++++K++V AL + ++ER +K L+++L +E N IE LK L Q + +EL ML+ E+ ++E+ ER+ K+ E+ ++++EL +AL R + YE G +GL EAV+EIK K Q++++++E E ++++NK + ++ EN L+ +L + +D+ ++ KA ++++ RA N VL KE+E LE+ER+ LKK++R LA++ G RA +M Y + + M + + + ++++ Q ++ +++EL + +KE + ED+ + L+ + AL+ ++++ TRN A ++ P L++L+ A+E+R G FD I+LK ++D L + E R I ++ L+ M+ G N+ + I LP+ +S +++ + +LN++++ +LQE KEQ++ K + AL+ Y+RKFA +RH+ GLLY++Y E++ +++E++ L+ +E + D +I E+ +LD L D E+K+++A+ R++TVL+VNE LTRRY+ + EMEQ +R++N KLK+++ +EA V +R+GY +R+KE A +K+ LQ+ LD+SVP ++ +++E+T KYR+ L+K N+L+ R + +E E + +K K LE K++ + LE LE + PA +++ K+ +N + ++S+SKK+ LEMK++NE++RA+H+ +MYE+++ T + E+RN ELE K ELT NLE QK+E+ LRD+L +SVSK ++DA+++R++ELEK E E K E+ KL+ +++IA MQ +AL +Q SREKE S+R+Q+ D Q QSDEK+LI KLH+ IV LQ+SE++A+ KL+ +++EA LR EQ D+KDQ LY R++GR R KHLR+T++SLR QFSG++PL++ E+F+ T+++L DK+K E++ + + +E E ++ + T LKDA R + V E W K+E LRL+ LK R+ + E+++L ++I QE ++ ++ED+ + + H+++Q+ W+QRE ELER + E+ Q EV+ AA F++AT G +PD + PLP QL+ A+ IK+H++ + + ++ + L + KE ++ +R E +L R+R INELRL+LPA+ + + S LN K + + + A T++ +Q RL K+E L +Y+ LL +ARE+ +KH E++K L ++L+ + + M ++ N +R LA +T + + LA + +QL ++KQK T K+N+ +RL+E I + LK + +L+ ++ E E +I + N E+ K TR+P MKN + +L Q+ KEKQ Q L L ++ +T Q+ + + N+Q+++DK T+DL +E +Q L+ + L+++++ + + E + L D KE KL+ DK ++E++N+EL+ +RIK+L N + + + + R I++ +L + ++ A K S+E++ WEE K+ Q + ++ KL+DKE ++ +L+KQL T + +EK ++ +L + G +D + A + V++LR++N ELE EI + + A DS ++++ LK NR LQ ++ LER+L+Q ++ T ++ + ++KE ++L +N+EL+F E A K++PRLK+++ + K+ DLLK EK E K +++++ G SGK+ ELEK I MK+VVE+ Q+ENE LK+APG++ NE++ L EN LKLE+ L+ VG +L+ RY+AK +G+ +++++ ++LRK+L E E EK RI + ++ARD+++ + N S + ++G+ S + +K +++ I L+S+LK K++ D LK L +ATER
Sbjct: 139 LTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSIMDRLRKEKEQHRLQVQELAEQLKAKNEEDDPVMRAVNAKVDEWKIILASKDEEISDYQKKIVDLREKLKIAQLDADKSSVLALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQL----------QTEKAEELVGMLNILEERVKES-ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKELKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYRAENQVLLKEVECLEEERIRLKKQIRKLAQEKGKRA---------LM--YNFWHMLTHM-TLHFFFKNEHLSKQLSEKEQELERYKT----ITAELKSKLKE--ISEDK--------KHLEQIPKDIFQALKDVEKD-HTRNGEA----TIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELKESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYILHLLQEVESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLENQKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDNGKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDMLQKDNLLVQRTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKATKAITN------------NEIVSISKKITMLEMKELNERQRAEHSQKMYEHLRTTLTQLEERNFELETKFAELTKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSALASRQQSREKEVESMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLRKMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLAQQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHSVELELKLKGLEELIST-LKDA----RGAQKVTE-WHRKIEELRLQDLKLSRELSQKKEEIKYLNNMISEQERTISILEEDLVQQGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEAT--------GEVPDSNLPLPEQLEIALRKIKEHVKAVVETKSVCRTLEEKLKEKDSLLRTAENNILSRDRVINELRLQLPAT---------AAKETLLSNLNQIKEDSEQHQALKVAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHAEDLKELHQKLNLYSDTSINNFKEAAKEFMKKPSLQIPSSA---NLIR--LAEMEQTVAEQENSLASLSNQLRKATSELEKQKQITIAKVNEFENSKTRLEEKHIVEIKK---LKNDAEDLRARIAETEKEINYLNTELEAQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLTLRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENALIEEAENLNQDLRGKEKALSKLQKDKDEMERDNEELK---KRIKDLTINFQGKVDLHNKHNTSEDLQRRIKKLEAELAK-KSEEAERKPSSKEEIIRWEESKKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSR---GVTVD--------------QVVGARTAESEREVEELRKKNQELENEIQHMKTKQALPRDS-VIDDLHLK-----NRFLQEKLQALERQLSQENTSRPSTSGLGSDDQTRELEKENLKLTSENVELQFHLEQANKDLPRLKDQIENLKEMCDLLKKEKIEAERK-----------VASVRGSGRSGKTVPELEKTIALMKRVVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIAENDRLRKELKTETETSEKLRIAKRNLEVIKEKLARDLEEA-RMNIAERSGPQLEGTQGKAWKSTVVSKMFENK-------IKELESELKKKNDGIVD------LKKLLKEATER 2166
BLAST of NPHP6 vs. Ensembl Xenopus
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 697.197 bits (1798), Expect = 0.000e+0 Identity = 591/1817 (32.53%), Postives = 1020/1817 (56.14%), Query Frame = 2
Query: 1988 TRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNL-EERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEA---PASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAK-----FDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQL-----SIQKQKMETTDKINQ-----SRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQEL-------DAMKIKLRLIEEE----NNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-----EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLK-------QMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSS----------------------------IIANLQSQLK------------------------DKHNQNPDSS---KVEELKLLYNKATERVSFLEKQLQSFSEQFGVAIDL 7135
TRN A ++ P L++L+ A+E+R G FD I+LK ++D L + E R I ++ L+ M+ G N+ + I LP+ +S +++ + +LN++++ +LQE KEQ++ K + AL+ Y+RKFA +RH+ GLLY++Y E++ +++E++ L+ +E + D +I E+ +LD L D E+K+++A+ R++TVL+VNE LTRRY+ + EMEQ +R++N KLK+++ +EA V +R+GY +R+KE A +K+ LQ+ LD+SVP ++ +++E+T KYR+ L+K N+L+ R + +E E + +K K LE K++ + LE LE + PA +++ K+ +N + ++S+SKK+ LEMK++NE++RA+H+ +MYE+++ T + E+RN ELE K ELT NLE QK+E+ LRD+L +SVSK ++DA+++R++ELEK E E K E+ KL+ +++IA MQ +AL +Q SREKE S+R+Q+ D Q QSDEK+LI KLH+ IV LQ+SE++A+ KL+ +++EA LR EQ D+KDQ LY R++GR R KHLR+T++SLR QFSG++PL++ E+F+ T+++L DK+K E++ + + +E E ++ + T LKDA R + V E W K+E LRL+ LK R+ + E+++L ++I QE ++ ++ED+ + + H+++Q+ W+QRE ELER + E+ Q EV+ AA F++AT G +PD + PLP QL+ A+ IK+H++ + + ++ + L + KE ++ +R E +L R+R INELRL+LPA+ + + S LN K + + + A T++ +Q RL K+E L +Y+ LL +ARE+ +KH E++K L ++L+ + + M ++ N +R LA +T + + LA + +QL ++KQK T K+N+ +RL+E I + LK + +L+ ++ E E +I + N E+ K TR+P MKN + +L Q+ KEKQ Q L L ++ +T Q+ + + N+Q+++DK T+DL +E +Q L+ + L+++++ + + E + L D KE KL+ DK ++E++N+EL+ K +++L+ N K +L + ++ +++ +E E + + +R P + S S+E++ WEE K+ Q + ++ KL+DKE ++ +L+KQL T + +EK ++ +L + G +D + A + V++LR++N ELE EI + + A DS ++++ LK NR LQ ++ LER+L+Q ++ T ++ + ++KE ++L +N+EL+F E A K++PRLK+++ + K+ DLLK EK E K +++++ G SGK+ ELEK I MK+VVE+ Q+ENE LK+APG++ NE++ L EN LKLE+ L+ VG +L+ RY+AK +G+ +++++ ++LRK+L E E EK RI + ++ARD+++ + N S + ++G+ S + +K +++ ++L S I+ NL++++K K QN D + ++E+LK YN+ ++ LE++L++ SEQFGV ID
Sbjct: 369 TRNGEA----TIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELKESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYILHLLQEVESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLENQKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDNGKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDMLQKDNLLVQRTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKATKAITN------------NEIVSISKKITMLEMKELNERQRAEHSQKMYEHLRTTLTQLEERNFELETKFAELTKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSALASRQQSREKEVESMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLRKMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLAQQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHSVELELKLKGLEELIST-LKDA----RGAQKVTE-WHRKIEELRLQDLKLSRELSQKKEEIKYLNNMISEQERTISILEEDLVQQGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEAT--------GEVPDSNLPLPEQLEIALRKIKEHVKAVVETKSVCRTLEEKLKEKDSLLRTAENNILSRDRVINELRLQLPAT---------AAKETLLSNLNQIKEDSEQHQALKVAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHAEDLKELHQKLNLYSDTSINNFKEAAKEFMKKPSLQIPSSA---NLIR--LAEMEQTVAEQENSLASLSNQLRKATSELEKQKQITIAKVNEFENSKTRLEEKHIVEIKK---LKNDAEDLRARIAETEKEINYLNTELEAQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLTLRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENALIEEAENLNQDLRGKEKALSKLQKDKDEMERDNEELK------KRIKDLTINFQGKVDLHNKHNTSEDLQRRIKKLEAELAKKSEEAERKPVRDDKS---SKEEIIRWEESKKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSR---GVTVD--------------QVVGARTAESEREVEELRKKNQELENEIQHMKTKQALPRDS-VIDDLHLK-----NRFLQEKLQALERQLSQENTSRPSTSGLGSDDQTRELEKENLKLTSENVELQFHLEQANKDLPRLKDQIENLKEMCDLLKKEKIEAERK-----------VASVRGSGRSGKTVPELEKTIALMKRVVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIAENDRLRKELKTETETSEKLRIAKRNLEVIKEKLARDLEEA-RMNIAERSGPQLEGTQGKAWKSTVVSKMFENKIKELESELKKKNDGIVDLKKLLKEATERELKTEKIVGNLKNEVKFIINMVNIINSKVFSILQEEIKNLKKELQNFDPTFFEEIEDLKYNYNEEVKKNIILEEKLKALSEQFGVHIDF 2094 HSP 2 Score: 130.954 bits (328), Expect = 2.024e-29 Identity = 97/303 (32.01%), Postives = 182/303 (60.07%), Query Frame = 2
Query: 689 LKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGH-QMRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL 1591
L ++LE + E+E++T EY MK +D + E R+Q++ L EQ+ +N+ DD +M VN +V++WK ++ +D EI ++ LR L+ + ++++K++V AL + ++ER +K L+++L +E N IE LK L+ T G SGH ++++ +EL ML+ E+ ++E+ ER+ K+ E+ ++++EL +AL R + YE G +GL EAV+EIK K Q++++++E E ++++NK + ++ EN L+ +L + +D+ ++ KA ++++ RA N VL
Sbjct: 33 LTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSIMDRLRKEKEQHRLQVQELAEQLKAKNEEDDPVMRAVNAKVDEWK-VLTSKDEEISDYQKKIVDLREKLKIAQLDADKSSVLALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQLQ-TEKGVSGHIEIKQAEELVGMLNILEERVKES-ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKELKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYRAENQVL 332
BLAST of NPHP6 vs. Ensembl Xenopus
Match: CEP290 (centrosomal protein 290 [Source:HGNC Symbol;Acc:HGNC:29021]) HSP 1 Score: 688.337 bits (1775), Expect = 0.000e+0 Identity = 579/1731 (33.45%), Postives = 991/1731 (57.25%), Query Frame = 2
Query: 1988 TRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNL-EERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEA---PASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAK-----FDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQL-----SIQKQKMETTDKINQ-----SRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLR-NLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-----EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLK-------QMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATER 7072
TRN A ++ P L++L+ A+E+R G FD I+LK ++D L + E R I ++ L+ M+ G N+ + I LP+ +S +++ + +LN++++ +LQE KEQ++ K + AL+ Y+RKFA +RH+ GLLY++Y E++ +++E++ L+ +E + D +I E+ +LD L D E+K+++A+ R++TVL+VNE LTRRY+ + EMEQ +R++N KLK+++ +EA V +R+GY +R+KE A +K+ LQ+ LD+SVP ++ +++E+T KYR+ L+K N+L+ R + +E E + +K K LE K++ + LE LE + PA +++ K+ +N + ++S+SKK+ LEMK++NE++RA+H+ +MYE+++ T + E+RN ELE K ELT NLE QK+E+ LRD+L +SVSK ++DA+++R++ELEK E E K E+ KL+ +++IA MQ +AL +Q SREKE S+R+Q+ D Q QSDEK+LI KLH+ IV LQ+SE++A+ KL+ +++EA LR EQ D+KDQ LY R++GR R KHLR+T++SLR QFSG++PL++ E+F+ T+++L DK+K E++ + + +E E ++ + T LKDA R + V E W K+E LRL+ LK R+ + E+++L ++I QE ++ ++ED+ + + H+++Q+ W+QRE ELER + E+ Q EV+ AA F++AT G +PD + PLP QL+ A+ IK+H++ + + ++ + L + KE ++ +R E +L R+R INELRL+LPA+ + + S LN K + + + A T++ +Q RL K+E L +Y+ LL +ARE+ +KH E++K L ++L+ + + M ++ N +R LA +T + + LA + +QL ++KQK T K+N+ +RL+E I + LK + +L+ ++ E E +I + N E+ K TR+P MKN + +L Q+ KEKQ Q L L ++ +T Q+ + + N+Q+++DK T+DL +E +Q L+ + L+++++ + + E + L D KE KL+ DK ++E++N+EL+ +RIK+L N + + + + R I++ +L + ++ A K S+E++ WEE K+ Q + ++ KL+DKE ++ +L+KQL T + +EK ++ +L + G +D + A + V++LR++N ELE EI + + A DS ++++ LK NR LQ ++ LER+L+Q ++ T ++ + ++KE ++L +N+EL+F E A K++PRLK+++ + K+ DLLK EK E K +++++ G SGK+ ELEK I MK+VVE+ Q+ENE LK+APG++ NE++ L EN LKLE+ L+ VG +L+ RY+AK +G+ +++++ ++LRK+L E E EK RI + ++ARD+++ + N S + ++G+ S + +K +++ I L+S+LK K++ D LK L +ATER
Sbjct: 503 TRNGEA----TIISVPSLERLIHAIESRNTEGIFDVSIHLKAQVDQLTGRNEELRQELKESRKEAINISCALEKANEKILHLENELEMLRQLEGANMIFKPINLPDGMSPTSTNLLNSLNEYILHLLQEVESKEQSVIKFEEALEEYKRKFAVIRHQHGLLYKEYMSEQESWQEELKKLKEENAKLENQKETDMVQIKEYTNLLDALKMDPDEMKKQVAENLRKMTVLRVNEKLLTRRYTTLLEMEQHLRKDNGKLKNDISDMEAAVAERLGYLQRYKEIAAFKIASLQRALDDSVPISELETANKQYNELTSKYRDMLQKDNLLVQRTADMEHLEHENASLKSQIAFYNKELEITKEKCNTLEQALEHINNLDGNPAMDKATKAITN------------NEIVSISKKITMLEMKELNERQRAEHSQKMYEHLRTTLTQLEERNFELETKFAELTKINLEAQKVEQALRDDLANSVSKAVSDADRKRIMELEKTEAELKAEMSKLRNVSDIAKMQVSALASRQQSREKEVESMRKQILDYQDQSDEKALIAKLHQQIVALQISESTAVGKLEAATAKLRKMEAYNLRLEQKIDDKDQALYYARMEGRNRAKHLRQTVHSLRRQFSGALPLAQQEKFSKTMMQLQNDKLKTIHEMERVQQERREAENHSVELELKLKGLEELIST-LKDA----RGAQKVTE-WHRKIEELRLQDLKLSRELSQKKEEIKYLNNMISEQERTISILEEDLVQQGKFHEERQMSWDQREVELERQLDMYEHQQNEVLSAAQKFEEAT--------GEVPDSNLPLPEQLEIALRKIKEHVKAVVETKSVCRTLEEKLKEKDSLLRTAENNILSRDRVINELRLQLPAT---------AAKETLLSNLNQIKEDSEQHQALKVAHQTVANMQARLNQKEEMLKKYQHLLAKAREEQEEVTKKHAEDLKELHQKLNLYSDTSINNFKEAAKEFMKKPSLQIPSSA---NLIR--LAEMEQTVAEQENSLASLSNQLRKATSELEKQKQITIAKVNEFENSKTRLEEKHIVEIKK---LKNDAEDLRARIAETEKEINYLNTELEAQKEANTRAPTSTMKNLVERLKNQVALKEKQQQALSKALLTLRAEMTSQAEQHIIAAAAQKEENINVQQIVDKETKDLKARIEKLNEQQLKLKEALKNSKSRENALIEEAENLNQDLRGKEKALSKLQKDKDEMERDNEELK---KRIKDLTINFQGKVDLHNKHNTSEDLQRRIKKLEAELAK-KSEEAERKPSSKEEIIRWEESKKWQIKIEGMRSKLKDKEKEVDSLTKQLTTLKDLYSKGEQEKLMLQKKLKSR---GVTVD--------------QVVGARTAESEREVEELRKKNQELENEIQHMKTKQALPRDS-VIDDLHLK-----NRFLQEKLQALERQLSQENTSRPSTSGLGSDDQTRELEKENLKLTSENVELQFHLEQANKDLPRLKDQIENLKEMCDLLKKEKIEAERK-----------VASVRGSGRSGKTVPELEKTIALMKRVVERVQKENEELKKAPGIVSNEKLTNLEMENEKLKLEIEKLQLHVGGQLSMRYEAKTKGIEKLIAENDRLRKELKTETETSEKLRIAKRNLEVIKEKLARDLEEA-RMNIAERSGPQLEGTQGKAWKSTVVSKMFENK-------IKELESELKKKNDGIVD------LKKLLKEATER 2134 HSP 2 Score: 139.043 bits (349), Expect = 8.848e-32 Identity = 114/334 (34.13%), Postives = 205/334 (61.38%), Query Frame = 2
Query: 689 LKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGH-QMRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGS 1684
L ++LE + E+E++T EY MK +D + E R+Q++ L EQ+ +N+ DD +M VN +V++WK I+ +D EI ++ LR L+ + ++++K++V AL + ++ER +K L+++L +E N IE LK L+ T G SGH ++++ +EL ML+ E+ ++E+ ER+ K+ E+ ++++EL +AL R + YE G +GL EAV+EIK K Q++++++E E ++++NK + ++ EN L+ +L + +D+ ++ KA ++++ RA N VL KE+E LE+ER+ LKK++R LA++ G RA
Sbjct: 141 LTKHLEYSVQEMEKMTDEYNKMKLMVQNSDSIMDRLRKEKEQHRLQVQELAEQLKAKNEEDDPVMRAVNAKVDEWKIILASKDEEISDYQKKIVDLREKLKIAQLDADKSSVLALQQALQERNNHIKMLTEKLEQHTQEMESNTFHIEKLKLQLQ-TEKGVSGHIEIKQAEELVGMLNILEERVKES-ERIAKLAESDAREKDKELVEALRRMREYEAGVYGLVEAVSEIKELKTQIKIRDQEIESLIKDLNKHHLKLNDILDENEELKQRLGLDPKTAIDLTEFKNIKALKEQQYRAENQVLLKEVECLEEERIRLKKQIRKLAQEKGKRAAC 472
BLAST of NPHP6 vs. Ensembl Mouse
Match: Cep290 (centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]) HSP 1 Score: 800.045 bits (2065), Expect = 0.000e+0 Identity = 688/2120 (32.45%), Postives = 1199/2120 (56.56%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQ---MRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGN-NTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLE--------KEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ +D + + E R+Q+ L + + +++ DD +M+ VN +VE+WK I+ +D EI + LR L+ + ++++K+N+ AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L++ G S+ +Q +I Q+L++K K ER+ ++ E ++++EL +AL+R K YE G +GL +AV EIK CKAQ+++++ E E + +NK ++ EN LR + + +D+ +R K + ++ RA N VL KEIE LE+ERL LK+K+R +A++ G R ++G+ +D E S IE RK N N + K +S EL+ K+ IAK ++ ++L EN + + +++I + + + ++ G L P L++L+ AME++ G FD ++LK ++D L + + R + + Q + + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK ++ + E ++ + +E +D ++ E++ +L L D +E+K+ L++ R+ITVL+VNE +L R+Y+ + EME+ +R+EN K ++++I +EA VT+++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E + +K EA+ K LE K++ H +E E+ E + + SN + KS +S ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K TELT NL+ QK+E+ LRDEL DSV+K ++DA+++R+LELEK E+E K E+ KL+EI++IA Q + L QQ SREKE SLR QL D Q QSDEK+LI KLH+H+V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + ++E + + + EL + R + V+ +W K+E LRL+ LK R+ + E+++L ++I E + ++E+I + ++ H+++Q+ W+QRE ELER + ++ Q E++ AA F+ +T G++PDPS PLPNQL+ A+ IK++I+VI + K+L + KE E+ +R E +L R++ INELRLRLPA+ DR + + ++ + KS++ TM A T++ +Q RL K+E L +Y+ LL++ARE+ +KH E++ +L +L +A + Q L + V T+ + E+ +A Q + L +L + L QK+ E + ++ + +E+ +K + +L+ L + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+V+++HTR+L +++E + +L+ + L++++ + + +L+ L + K+ K+ +K ++QENDELR Q++R+ + L++ + D + +D ++ K++ +E +QL+R P K +SK E++ WEEGK+ Q + L+ +L++KE + L+KQL+T + + +EK ++ +L G +D + + A + D +D+ MR + +V +++ ++N+ LQ + LE++L++ + +T E KE+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK K LE K + ++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN +LK EL LK G +L+ ++++K +G ++V++ E+LRK+L +E E EK RI + DK+ Q + +L +ESR Q
Sbjct: 218 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTK----EAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGL----TIDDLNLSETFSHENKIE--------GRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQ-------ETKLGNDSNMDKAKKS--MTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVI-NWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDST--------GSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEP-----KSHH----TMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLE---SQLERKVDDVDIKPVKEKSSK----EELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLK---TTGMTVD---QVLGVRALESEKELEELKKKNLDLENDI------------LYMRTQQALPRDSV----VEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERK-----------LGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQ 2251
BLAST of NPHP6 vs. Ensembl Mouse
Match: Cep290 (centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]) HSP 1 Score: 799.275 bits (2063), Expect = 0.000e+0 Identity = 688/2120 (32.45%), Postives = 1199/2120 (56.56%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQ---MRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGN-NTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLE--------KEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ +D + + E R+Q+ L + + +++ DD +M+ VN +VE+WK I+ +D EI + LR L+ + ++++K+N+ AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L++ G S+ +Q +I Q+L++K K ER+ ++ E ++++EL +AL+R K YE G +GL +AV EIK CKAQ+++++ E E + +NK ++ EN LR + + +D+ +R K + ++ RA N VL KEIE LE+ERL LK+K+R +A++ G R ++G+ +D E S IE RK N N + K +S EL+ K+ IAK ++ ++L EN + + +++I + + + ++ G L P L++L+ AME++ G FD ++LK ++D L + + R + + Q + + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK ++ + E ++ + +E +D ++ E++ +L L D +E+K+ L++ R+ITVL+VNE +L R+Y+ + EME+ +R+EN K ++++I +EA VT+++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E + +K EA+ K LE K++ H +E E+ E + + SN + KS +S ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K TELT NL+ QK+E+ LRDEL DSV+K ++DA+++R+LELEK E+E K E+ KL+EI++IA Q + L QQ SREKE SLR QL D Q QSDEK+LI KLH+H+V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + ++E + + + EL + R + V+ +W K+E LRL+ LK R+ + E+++L ++I E + ++E+I + ++ H+++Q+ W+QRE ELER + ++ Q E++ AA F+ +T G++PDPS PLPNQL+ A+ IK++I+VI + K+L + KE E+ +R E +L R++ INELRLRLPA+ DR + + ++ + KS++ TM A T++ +Q RL K+E L +Y+ LL++ARE+ +KH E++ +L +L +A + Q L + V T+ + E+ +A Q + L +L + L QK+ E + ++ + +E+ +K + +L+ L + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+V+++HTR+L +++E + +L+ + L++++ + + +L+ L + K+ K+ +K ++QENDELR Q++R+ + L++ + D + +D ++ K++ +E +QL+R P K +SK E++ WEEGK+ Q + L+ +L++KE + L+KQL+T + + +EK ++ +L G +D + + A + D +D+ MR + +V +++ ++N+ LQ + LE++L++ + +T E KE+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK K LE K + ++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN +LK EL LK G +L+ ++++K +G ++V++ E+LRK+L +E E EK RI + DK+ Q + +L +ESR Q
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTK----EAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGL----TIDDLNLSETFSHENKIE--------GRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQ-------ETKLGNDSNMDKAKKS--MTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVI-NWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDST--------GSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEP-----KSHH----TMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLE---SQLERKVDDVDIKPVKEKSSK----EELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLK---TTGMTVD---QVLGVRALESEKELEELKKKNLDLENDI------------LYMRTQQALPRDSV----VEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERK-----------LGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQ 2258
BLAST of NPHP6 vs. Ensembl Mouse
Match: Cep290 (centrosomal protein 290 [Source:MGI Symbol;Acc:MGI:2384917]) HSP 1 Score: 799.275 bits (2063), Expect = 0.000e+0 Identity = 688/2120 (32.45%), Postives = 1199/2120 (56.56%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQ---MRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGN-NTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLE--------KEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ +D + + E R+Q+ L + + +++ DD +M+ VN +VE+WK I+ +D EI + LR L+ + ++++K+N+ AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L++ G S+ +Q +I Q+L++K K ER+ ++ E ++++EL +AL+R K YE G +GL +AV EIK CKAQ+++++ E E + +NK ++ EN LR + + +D+ +R K + ++ RA N VL KEIE LE+ERL LK+K+R +A++ G R ++G+ +D E S IE RK N N + K +S EL+ K+ IAK ++ ++L EN + + +++I + + + ++ G L P L++L+ AME++ G FD ++LK ++D L + + R + + Q + + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK ++ + E ++ + +E +D ++ E++ +L L D +E+K+ L++ R+ITVL+VNE +L R+Y+ + EME+ +R+EN K ++++I +EA VT+++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E + +K EA+ K LE K++ H +E E+ E + + SN + KS +S ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K TELT NL+ QK+E+ LRDEL DSV+K ++DA+++R+LELEK E+E K E+ KL+EI++IA Q + L QQ SREKE SLR QL D Q QSDEK+LI KLH+H+V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + ++E + + + EL + R + V+ +W K+E LRL+ LK R+ + E+++L ++I E + ++E+I + ++ H+++Q+ W+QRE ELER + ++ Q E++ AA F+ +T G++PDPS PLPNQL+ A+ IK++I+VI + K+L + KE E+ +R E +L R++ INELRLRLPA+ DR + + ++ + KS++ TM A T++ +Q RL K+E L +Y+ LL++ARE+ +KH E++ +L +L +A + Q L + V T+ + E+ +A Q + L +L + L QK+ E + ++ + +E+ +K + +L+ L + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+V+++HTR+L +++E + +L+ + L++++ + + +L+ L + K+ K+ +K ++QENDELR Q++R+ + L++ + D + +D ++ K++ +E +QL+R P K +SK E++ WEEGK+ Q + L+ +L++KE + L+KQL+T + + +EK ++ +L G +D + + A + D +D+ MR + +V +++ ++N+ LQ + LE++L++ + +T E KE+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK K LE K + ++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN +LK EL LK G +L+ ++++K +G ++V++ E+LRK+L +E E EK RI + DK+ Q + +L +ESR Q
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTK----EAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGL----TIDDLNLSETFSHENKIE--------GRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQ-------ETKLGNDSNMDKAKKS--MTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVI-NWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDST--------GSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEP-----KSHH----TMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLE---SQLERKVDDVDIKPVKEKSSK----EELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLK---TTGMTVD---QVLGVRALESEKELEELKKKNLDLENDI------------LYMRTQQALPRDSV----VEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERK-----------LGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQ 2258
BLAST of NPHP6 vs. UniProt/SwissProt
Match: sp|P85001|CE290_DANRE (Centrosomal protein of 290 kDa OS=Danio rerio OX=7955 GN=cep290 PE=2 SV=1) HSP 1 Score: 852.047 bits (2200), Expect = 0.000e+0 Identity = 746/2337 (31.92%), Postives = 1299/2337 (55.58%), Query Frame = 2
Query: 29 SSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDL-----EEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVR-EKRNWEMEKESMNQEIRELKSKYNSLTEDNDK-------KEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXX-XXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXX----XXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAV-DSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSV--LESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNG--QLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHT-------RDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEE-NNQLKRNPA-KSANSKQD--SQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG 6904
+++DW ++ + + L D+I LMV D+ DD++K+ + F I+Q ++ K +E K E + E+A ++ + + + + A + G D + +R E R E E +E+ +L+ + + N++ EE K ++EI+ L N +L ++EF R+ Q ++ + + + + + L +L Q +L +A++ L E +HL++NLE + E+E++T EY MK TD + + ++Q+ L +Q+ R + DD +M VN +VE+WK ++ +D EI + LR L+ + ++S+K+N+ AL + V+ER+ ++K LS+Q+ +E N LIE LK+ L++ G SS HQ RR+++L L E+ + E E D+++EL D L R ++YE G GL A++EIK CK Q++V++RE E ++ +N+ L EN LR +L + E+LD+ +RR K + + +A N VL KEIE+LE+ERL LK+++R L + G+ S + L++S +E PV + + S + R ER + ELSN KE ++ E A+ + ++ EN + +++I + + + GV + P L++L+ A+E + G+FD ++L+T++D L GRNEE ++ + QL ++K+ + M+ M + + LPE ++ ++++ I ALN++ + +LQE K ++++ AL+ Y+RKFA +RH+QGLLY+++ E++ +++E ++ +E R D +I E++ +L+TL +D SE++R +A+ R+I VL+VNE LTRRY+ + E+EQ +R+EN KLK + Q++AVVT+R+GY +RFKE A +K+ LQK LD SVP ++ + ++ E+T KYRN L+K N L+ + S+ +E+E ++ +++ K LE K++ H LE E +I +T K+ AV +S ++S+S+++ TLEMK++NE++RA+HA +MYE+++N+ + E+RN ELE K ELT NLE Q+IERELRDEL DSVSK I+DA+++R+ ELEK E + E+ KL+E++++A MQ +AL +Q SREKE SLR+Q+ D Q +SDEK+LI KLH+HIV LQ+SET+A+ +L+ + ++LEAQ LR EQ DE+ Q L+ R +G R +HLR TI +LR QFSG++PL++ E+F++T++ L ED+ ++ ++ Q+ + E + Q + + L++ +AT ++ K + W K+E +RL ++ R+ + R E+++L++ + QE ++ ++E++ + +++QL+W+QRE +LER + + E Q EV+ A F++AT G+LPDP+ PL NQLD A+ IK+H+R I + + K L + KE E + E +L R++ INELRLRLPA+ +R + + +S ++ + + T+ A T++ LQ RL K+E L +Y+ LL +AR++ ++H EE++ L ++L R + T V TS E+ +A Q + L +L + +L Q+Q + + + E K ++ L + L+ +L + E ++ + E+ K RSP+ MKN + +L QL KEKQL+ L L +++ +T Q+ + + N+Q+++DK T RDL+ EL+ +D + R+A+A + ++ +L+ L D + + KL+++K LE+ +EL+ ++QR+ + L+ +D +D+++ K+R +E E + + PA K + K+D S+E+V WEEGK+ Q DK++ L++KE ++ + +KQL T + R+ +EK +++ +L G G D + A +++L +RN ELE++I ++M+ + + A+++ +RNR L+ + +E RL++ SG S ++E QKE +RL+ +NLEL+F+ E A K++PRLK++V+D K+ +LK EK +E + +S+++ G SGK+ ELEK IG MKKVVEK QRENE LK+ V + EQ+ L ++ LK E LK + +L R ++K +G+ +++ + E+LRK++ +EAE EK R+ + +KL+ + + +L +++S+G
Sbjct: 3 AAADWRLLMGMDPEDLGDEDEKICDLI--LMVKPRDL-KADDSEKMIQLFRISQTLLRMKLDEIKCAYEVVDSAGAEQARIENELKAKVLKLESELEMAQRVMGGGDKHFLRDEIRQLESHLERKEKEVTQLEKEMGKERKSNEELALRAEEAEEKNRKLKREIKQLTRKNEQLQQDIEFYRKEAEQRESLQTKEESNEIQRRLTKANQQLYQCMEELQHAEDMAANLRSENEHLQKNLEESVKEMEKMTDEYNKMKIAVQQTDAIMDQLRKDRDHAKLQVRELTDQIQARVEEDDPVMAAVNAKVEEWKSVLSGKDLEILEYQQMIRDLREKLRTAQMDSDKSNIIALQQAVQERDNQIKMLSEQVEQYTTEMERNAMLIEELKRPLKKDKGHSSDHQ-RRLEDLSAKLQVAERKVLEAQRAAQLAERDARDKDKELNDTLSRIRLYESGTDGLEAAISEIKECKNQIRVRDREIEGMIKEINQLEMKINNLLDENEDLRERLGLNPKEELDLSEFRRSKILKQRQYKAENQVLLKEIERLEEERLELKQRIRALVKDKGVTVVSNSL-------------LDNS---VEEKPVR---SLRPSSGSTDDEIKRKNER-LQKELSNKEKELELRRSESAQFKAKLNEMLNENKQLEQGMKEILQAIQDTQKKTPTSTGVSI---PSLERLVNALEMKYSEGKFDASLHLRTQVDQLTGRNEELRLEMKTAREEAANTLSQLTKANEKIARLESEMESMSKSTGSSIPHKTLALPEEMTPTSAEAINALNEYTVQLLQEIKNKGDSIEQLGSALEEYKRKFAVIRHQQGLLYKEHQSERESWQKERDSFAELKSKLEEQREVDAVKIKEYNHLLETLEKDPSEIRREMAETGRKIVVLRVNEKCLTRRYTTLLELEQHLRKENAKLKEDFTQMQAVVTERIGYLQRFKEMAAFKMASLQKSLDVSVPASELERANKQYTELTIKYRNLLQKDNHLVQKTTSLEHLETENMSLRERIDSINKELEISKEKLHTLEQAFE----------NISTTGGEIIMDKATKAVANSEIVSVSRRITTLEMKELNERQRAEHAQKMYEHLRNSLKQVEERNFELETKFAELTKLNLEAQRIERELRDELADSVSKHISDADRKRITELEKTEANLRIEVSKLREVSDVAKMQVSALDARQQSREKEVESLRRQVLDYQAESDEKALIAKLHQHIVALQLSETTAISRLEATNTRLQKLEAQKLRDEQKLDEQQQALWHARQEGHQRARHLRHTIQALRRQFSGALPLAQQEKFSNTMLHLQEDRARVREDAQIAEEERRKAEGKAQELELKLKG---LEELIATLKDAKGAQKVSEWHKKLEDVRLLEMRQSRELNTQREEIKYLKNCVAEQECTISGLEEELVQQNNLLEERQLIWDQREVQLERQLDSYEKQQNEVLNTAQKFEEAT--------GSLPDPNQPLANQLDYALGKIKEHVRTILETKTTCKILEEKLKEKEAALWSSEQNVLSRDKVINELRLRLPAAAEREKLLADLS----------KQEDSESQPTLKVAHQTINNLQGRLDQKEEVLKKYQNLLGKARQEQEEIAKRHEEEVRALHQKLDVYMDTSLDRFKQTALELIKKPTITVPTSKHLVRLAEMEQTVAEQDNSLSSLSQKLKIVTQELDQQRQVTAAQAMEHAADMARLEDKHAAQMKGLSQEAEELRAQLIQMEKELHYLRTELEAQKEANVRSPSNTMKNLVERLKNQLALKEKQLKALSKALLELRAELTSQAEQQIITNAAQKEEALNVQQIVDKQTKELRACVRDLNEELQLAKDGV-------RAAKARENSLKEDLETLNKDLQRSQKSQNKLQSEKEALEEHLNELKKKIQRLSSGLQAQVESDGPT--VDSLQKKIRKLEHELDRKSISEPADKRSTLKEDKSSKEEVVRWEEGKKWQARVDKMRNVLKEKEREVDSQAKQLATMKELYSRLEQEKVSLQKKLK---GRGVTAD--------------QVVGARTLEADKEIEELHKRNAELEQQI-KVMKQQQA----LPRDAAMEDITIRNRYLEERLYSMESRLSKEPPSRPSTSGRGSDTPSQREHEFQKENLRLSTENLELRFQLEQANKDLPRLKDQVSDLKEMCSVLKKEKAEVEKR-----------LSHLRGSGRSGKTIPELEKTIGLMKKVVEKVQRENENLKKTSEVNVQEQLATLERDHEKLKSEYEKLKGKQEEQLNSRLESKTKGIEKIMMENERLRKEIKKEAEAAEKLRVAKASLEVANEKLKAELEETHQRLLLAQSKG 2239
BLAST of NPHP6 vs. UniProt/SwissProt
Match: sp|Q6A078|CE290_MOUSE (Centrosomal protein of 290 kDa OS=Mus musculus OX=10090 GN=Cep290 PE=1 SV=2) HSP 1 Score: 800.045 bits (2065), Expect = 0.000e+0 Identity = 688/2120 (32.45%), Postives = 1199/2120 (56.56%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQ---MRRIKELRQMLDDKEKMLRETVERLNKV-ENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGN-NTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEEL--VTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLE--------KEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ +D + + E R+Q+ L + + +++ DD +M+ VN +VE+WK I+ +D EI + LR L+ + ++++K+N+ AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L++ G S+ +Q +I Q+L++K K ER+ ++ E ++++EL +AL+R K YE G +GL +AV EIK CKAQ+++++ E E + +NK ++ EN LR + + +D+ +R K + ++ RA N VL KEIE LE+ERL LK+K+R +A++ G R ++G+ +D E S IE RK N N + K +S EL+ K+ IAK ++ ++L EN + + +++I + + + ++ G L P L++L+ AME++ G FD ++LK ++D L + + R + + Q + + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK ++ + E ++ + +E +D ++ E++ +L L D +E+K+ L++ R+ITVL+VNE +L R+Y+ + EME+ +R+EN K ++++I +EA VT+++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E + +K EA+ K LE K++ H +E E+ E + + SN + KS +S ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K TELT NL+ QK+E+ LRDEL DSV+K ++DA+++R+LELEK E+E K E+ KL+EI++IA Q + L QQ SREKE SLR QL D Q QSDEK+LI KLH+H+V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + ++E + + + EL + R + V+ +W K+E LRL+ LK R+ + E+++L ++I E + ++E+I + ++ H+++Q+ W+QRE ELER + ++ Q E++ AA F+ +T G++PDPS PLPNQL+ A+ IK++I+VI + K+L + KE E+ +R E +L R++ INELRLRLPA+ DR + + ++ + KS++ TM A T++ +Q RL K+E L +Y+ LL++ARE+ +KH E++ +L +L +A + Q L + V T+ + E+ +A Q + L +L + L QK+ E + ++ + +E+ +K + +L+ L + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+V+++HTR+L +++E + +L+ + L++++ + + +L+ L + K+ K+ +K ++QENDELR Q++R+ + L++ + D + +D ++ K++ +E +QL+R P K +SK E++ WEEGK+ Q + L+ +L++KE + L+KQL+T + + +EK ++ +L G +D + + A + D +D+ MR + +V +++ ++N+ LQ + LE++L++ + +T E KE+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK K LE K + ++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN +LK EL LK G +L+ ++++K +G ++V++ E+LRK+L +E E EK RI + DK+ Q + +L +ESR Q
Sbjct: 218 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKALVHQSDAVMDQIKKENEHYRLQVRELTDLLKAKDEEDDPVMMAVNAKVEEWKLILSSKDDEIIEYQQMLQSLRGKLKNAQLDADKSNIMALKQGIQERDSQIKMLTEQVEQYTKEMEKNTFIIEDLKNELQKDKGTSNFYQQTHYMKIHSKVQILEEKTK----EAERIAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVIEIKNCKAQIKIRDGEMEVLTKEINKLEMKINDILDENEALRERAGLEPKTMIDLTEFRNSKRLKQQQYRAENQVLLKEIESLEEERLDLKRKIRQMAQERGKRNAASGL----TIDDLNLSETFSHENKIE--------GRKLNFMSLNNMNETQSKNEFLSRELAEKEKDLERSRTVIAKFQSKLKELVEENKQLEEGMKEILQAIKDMPKDSDVKGGETSLIIPSLERLVNAMESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRQSRKEAVNYSQQLVKANLKIDHLEKETDLLRQSAGSNVVYKGIDLPDGIAPSSAYIINSQNEYLIHLLQELDNKEKKLKHLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKDIWKTDSEMIREEKRKLEDQAEQDAVKVKEYNNLLSALQMDSNEMKKMLSENSRKITVLQVNEKSLIRQYTTLVEMERHLRKENGKHRNDVIAMEAEVTEKLGSLQRFKEMAIFKIAALQKVIDNSVSLSELELANKQYNELTTKYRDILQKDNMLVQRTSNLEHLECENASLKEQMEAISKELEITKEKLHTIEQAWEQ-------ETKLGNDSNMDKAKKS--MTNSDIVSISKKITVLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFTELTKINLDAQKVEQMLRDELADSVTKAVSDADRQRILELEKSEVELKVEVSKLREISDIAKRQVDFLNSQQQSREKEVESLRTQLLDFQAQSDEKALIAKLHQHVVSLQISEATALGKLESVTSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLELELKLKGLEELISTLKDARGAQKVI-NWHVKIEELRLQELKLNRELVKGKEEIKYLNNIISEYEHTINSLEEEIVQQSKFHEERQMAWDQREVELERQLDIFDHQQNEILSAAQKFEDST--------GSMPDPSLPLPNQLEIALRKIKENIQVILKTQATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATADREKLIAELERKELEP-----KSHH----TMKIAHQTIANMQARLNHKEEVLKKYQHLLEKAREEQREIVKKHEEDLHVLHHKLEQQADNSLNKFRQTAQDLLKQSPAPVPTNKHFIRLAEMEQTVAEQDDSLSSLLTKLKKVSKDLEKQKEITELKVREFENTKLRLQETHASEVKKVKAEVEDLRHALAQAHKDSQSLKSELQAQKEANSRAPTTTMRNLVDRLKSQLALKEKQQKALSRALLELRSEMTAAAEERIIAVTSQKEANLNVQQVVERHTRELKSQIEDLNENLLKLKEALKTSKNKENSLADDLNELNNELQKKQKAYNKILREKDGIDQENDELRRQIKRLSSGLQSKTLIDNKQSLIDELQKKVKKLE---SQLERKVDDVDIKPVKEKSSK----EELIRWEEGKKWQTKVEGLRNRLKEKEGEAHGLAKQLNTLKELFAKADKEKLTLQKKLK---TTGMTVD---QVLGVRALESEKELEELKKKNLDLENDI------------LYMRTQQALPRDSV----VEDLHLQNKYLQEKLHTLEKKLSKEKYSQSLTSEIESDDHCQKEQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVKDLKEMCEFLKKGKLELERK-----------LGQVRGAGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMATIEEENRNLKAELEKLKAHFGRQLSMQFESKNKGTEKIVAENERLRKELKKEIEASEKLRIAKNNLELVNDKMAAQLEETGKRLQFAESRAPQ 2251
BLAST of NPHP6 vs. UniProt/SwissProt
Match: sp|O15078|CE290_HUMAN (Centrosomal protein of 290 kDa OS=Homo sapiens OX=9606 GN=CEP290 PE=1 SV=2) HSP 1 Score: 796.193 bits (2055), Expect = 0.000e+0 Identity = 697/2129 (32.74%), Postives = 1212/2129 (56.93%), Query Frame = 2
Query: 638 LDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNI-EYDPV----MQSMARKYESAPQGNNTW---RIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXX---XXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEE---LGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFD-----LETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQ--------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQ 6910
L A EKI +QEM ++NLE + E+E++T EY MK+ TD + + E ++Q++ L + + +N+ DD IM+ VN +VE+WK I+ +D EI + LR L+ + ++++K+NV AL + ++ER+ ++K L++Q+ +E+N +IE+LK +L+R G S+ Q +K ++ LD ++ +E E ++++EL +AL+R K YE G +GL +AV EIK CK Q+++++RE E + +NK + EN LR ++ + +D+ +R K + ++ RA N +L KEIE LE+ERL LKKK+R +A++ G R+ ++G+ D+ + +NI + D + + ++ K S Q N + + E+E E S V A ++++ +L+ N+QL+ + M + L+ IKE + ++ G L P L++L+ A+E++ G FD ++LK ++D L + E R I + Q + L+ ++ G N+ + I LP+ ++ S++ I + N++LI +LQE KE+ L + +L++Y RKFA +RH+Q LLY++Y EK+ ++ E + ++ + +E +D ++ E++ +L+ L D E+K+ LA+ R+ITVL+VNE +L R+Y+ + E+E+ +R+EN K K+E++ +EA V +++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E +K E++ K LE K++ H +E E+ LG + +++ KS +NS ++S+SKK+ LEMK++NE++RA+H +MYE+++ + + E+RN ELE K ELT NL+ QK+E+ LRDEL DSVSK ++DA+++R+LELEK E+E K E+ KL+EI++IA Q L QQ SR+KE SLR QL D Q QSDEKSLI KLH+H V LQ+SE +AL KL+ + +++EA LR EQ DEK+Q LY RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ QE++ + + + LE E ++ + T LKD TK +K + +W K+E LRL+ LK R+ + E+++L ++I E ++ ++E+I + + H+++Q+ W+QRE +LER + + Q E++ AA F++AT G++PDPS PLPNQL+ A+ IK++IR+I + K+L + KE E+ +R E +L R++ INELRLRLPA+ +R + + ++ + KS++ T+ A T++ +Q RL K+E L +Y++LL++ARE+ +KH E++ +L RL +A + + + + T V T+ + E+ +A Q + L ++L + L Q++ E K ++ + + E+E+ +K + +LK L++ + + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + ++ N+Q+++D+HTR+L ++E + +L+ + L++++ + + L+ L + K+ K+ +K +++QENDEL+ Q++R+ + L+ D + ++ ++ K++ +E NQL+ P K N+K E++ WEEGK+ Q + ++ KL++KE ++ L+KQL+T + +EK ++ +L G +D + I A + RN +LE +I MR + +V +++ ++NR LQ + LE++ ++ SG S ++E+ +QKE ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK EK ++ K + +++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN LK EL LK +GH+L+ Y++K +G +++++ E+LRK+L +E + EK RI + +K+ Q + +L +ESRG Q
Sbjct: 225 LTEANEKIEVQNQEM---RKNLEESVQEMEKMTDEYNRMKAIVHQTDNVIDQLKKENDHYQLQVQELTDLLKSKNEEDDPIMVAVNAKVEEWKLILSSKDDEIIEYQQMLHNLREKLKNAQLDADKSNVMALQQGIQERDSQIKMLTEQVEQYTKEMEKNTCIIEDLKNELQRNKGASTLSQQTHMK-IQSTLDILKEKTKEAERTAELAEADAREKDKELVEALKRLKDYESGVYGLEDAVVEIKNCKNQIKIRDREIEILTKEINKLELKISDFLDENEALRERVGLEPKTMIDLTEFRNSKHLKQQQYRAENQILLKEIESLEEERLDLKKKIRQMAQERGKRSATSGLTTEDL----------NLTENISQGDRISERKLDLLSLKNMSEAQSKNEFLSRELIEKERDLERSRTV--IAKFQNKLKELVEENKQLE---EGMKEILQAIKE--MQKDPDVKGGETSLIIPSLERLVNAIESKNAEGIFDASLHLKAQVDQLTGRNEELRQELRESRKEAINYSQQLAKANLKIDHLEKETSLLRQSEGSNVVFKGIDLPDGIAPSSASIINSQNEYLIHLLQELENKEKKLKNLEDSLEDYNRKFAVIRHQQSLLYKEYLSEKETWKTESKTIKEEKRKLEDQVQQDAIKVKEYNNLLNALQMDSDEMKKILAENSRKITVLQVNEKSLIRQYTTLVELERQLRKENEKQKNELLSMEAEVCEKIGCLQRFKEMAIFKIAALQKVVDNSVSLSELELANKQYNELTAKYRDILQKDNMLVQRTSNLEHLECENISLKEQVESINKELEITKEKLHTIEQAWEQETKLGNESSMDKAKKSITNSD------------IVSISKKITMLEMKELNERQRAEHCQKMYEHLRTSLKQMEERNFELETKFAELTKINLDAQKVEQMLRDELADSVSKAVSDADRQRILELEKNEMELKVEVSKLREISDIARRQVEILNAQQQSRDKEVESLRMQLLDYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELIST-LKD---TKGAQKVI--NWHMKIEELRLQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEAT--------GSIPDPSLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEP-----KSHH----TLKIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEALKTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLE---NQLEGKVEEVDLKPMKEKNAK----EELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLK---TTGMTVD---QVLGIRALESEKELEELKK-----------RNLDLENDI-LYMRAHQALPRDSV----VEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRK-----------LGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRGPQ 2257
BLAST of NPHP6 vs. UniProt/SwissProt
Match: sp|Q9TU23|CE290_BOVIN (Centrosomal protein of 290 kDa (Fragment) OS=Bos taurus OX=9913 GN=CEP290 PE=1 SV=2) HSP 1 Score: 549.28 bits (1414), Expect = 4.572e-163 Identity = 507/1528 (33.18%), Postives = 873/1528 (57.13%), Query Frame = 2
Query: 2711 EQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQ------LTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQ--LPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSID-ALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRI-KNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKR-------NPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSG----STSVI----TLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDL-----------GREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKD----------------KHNQNPDSS---KVEELKLLYNKATERVSFLEKQLQSFSEQFGVAI 7129
E+ +R+EN K K+E++ +EA V +++G +RFKE A +K+ LQK +D SV ++ +++E+T KYR+ L+K N+L+ R ++ +E E +K E++ K LE K++ H +E E+ E + + SN + KS +S ++S+SKK+ LEMK++NE++RA+H+ +MYE++K + + E+RN ELE K ELT NLE QK+E+ LRDEL DSVSK ++DA+++ +LELEK E+E K E+ KLKEI++IA Q L QQ SREKE SLR QL D Q QSDEK+LI KLH+H+V LQ SE +AL K++ + +++EA LR EQ DEK+Q L+ RL+GR R KHLR+TI SLR QFSG++PL++ E+F+ T+I+L DK+K+ +E++ +L+ K LE E ++ + T LKDA R + V+ SW +K+E LRL+ LK R+ + E+++L ++I E+ ++ ++E+I + + H+++Q+ W+QRE ELER + + Q E++ A F++AT G++PDPS P+PNQL+ A+ IK++IR+I + + ++L + +E E+ +R E +L R++ INELRLRLPA+ ++ + + + S V KS++ T+ A T++ +Q RL K+E L +Y+ LL++ARE+ +KH EE+ L +L +A + + + T V T+ + E+ +A Q + L ++L + L QK+ E K ++ + +E+ +K + +L+ L + + + + E+ K +R+P M+N + +L QL KEKQ + L L +++ +T + + + MT + AN N+Q+++D+HT++L +++E + IL+ + L++++ + + L+ L + +K+ K+ +K ++QEN+EL+ Q++R+ L+ D + ++ ++ K++ +E +QL+R P K +++ E+V WEEGK+ Q + ++ KL++KE ++ L+KQL T + +EK ++ +L G +D + MA A +++L++RN +LE +I MR+ + +V +++ ++N+ LQ + LE++L++ STS I ++E+ +Q+E ++L+ +N+ELKF+ E A K++PRLK +V D K+ + LK EK +E K R ++ G SGK+ ELEK IG MKKVVEK QRENE+LK+A G++ +E++ + EN LK EL LK +G +L+ Y++K +G ++V++ E+LRK+L G E E+ + + + ++A +LEK+ +L ++ IS+ + + S I++ + L I +L++QL+ K +N D S ++E+LK Y + ++ LE++L+ SEQFGV +
Sbjct: 1 ERQLRKENGKQKNELMAMEAEVGEKIGRLQRFKEMAVFKIAALQKVVDNSVSLSELELANRQYNELTAKYRDILQKDNMLVQRTNNLEHLECENVSLKEQMESINKELEITKEKLHTIEQAWEQ-------ETKLGNESNMDKAKKS--VTNSEIVSISKKITMLEMKELNERQRAEHSQKMYEHVKTSLQQVEERNFELETKFAELTRINLEAQKVEQMLRDELADSVSKTVSDADRQHILELEKSEMELKVEVSKLKEISDIAKRQVEILNAQQQSREKEVESLRTQLLDYQAQSDEKALIAKLHQHVVSLQASEAAALGKVESVASKLQKVEAHTLRLEQKLDEKEQALFYARLEGRNRAKHLRQTIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMEEMKNSQQEHRSLKNK-TLEMELKLKGLEDLIST-LKDA----RGAQKVI-SWHTKIEELRLQELKLNRELVKDKEEIKYLNNIISEYENTISSLEEEIVQQNKFHEERQMAWDQREVELERQLDVFDRQQSEILREAQKFEEAT--------GSMPDPSLPIPNQLEIALRKIKENIRIILETQATCRSLEEKLREKESALRLAEENILSRDKVINELRLRLPATAEQEKLLAEFSRKEVEP-----KSHH----TLKLAHQTIANMQARLNQKEEVLKKYQHLLEKAREEQREIVKKHEEELHTLHRKLELQADNSLSKFKETAWDLIKQSPTPVPTNKHFIRLAEMEQTVAEQDDSLSSLVIKLKQVSQDLERQKEITELKIKEFENMKLRLQENHADEVKKIKAEVEDLRCLLVQSQKESQSLKSELQTQKEANSRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISMTSQKEANL-NVQQIVDRHTKELKSQIEDLNENILKLKEALKTSKNRENTLTDNLNDLTNELQNKQKAYGKVLREKDAVDQENNELKRQIKRLTSGLQGKPLIDNKQSLIEELQKKIKKLE---SQLERKVDEAEMKPMKEKSAR----EEVIRWEEGKKWQTKIEGIRNKLKEKEGEVYILTKQLTTLKDLFAKADKEKLTLQRKLK---TTGLTVD-------------QVMA-ARVLESEKELEELKKRNLDLENDIS-YMRSHQALPRDSV----IEDLHLQNKYLQEKLHALEKQLSKDAYSRPSTSGIDSDDHYQREQELQRENLKLSSENIELKFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVERKLGR-----------VRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMANIEMENEKLKAELEKLKVHLGRQLSMHYESKAKGTEKIVAENERLRKELKKIEILKHVPEGDETEQGLQRELRVLRLAN--SQLEKEKEELIHRIEISKDQNGPD-STISDPD------HLMEKIKDLETQLRTSDMEKQHLKEEIQKLKKELENFDPSFFEEIEDLKYNYKEEVKKNILLEEKLKKLSEQFGVEL 1445
BLAST of NPHP6 vs. TrEMBL
Match: A0A0H3YKK9 (NPHP6 OS=Schmidtea mediterranea OX=79327 GN=NPHP6 PE=2 SV=1) HSP 1 Score: 4374.7 bits (11345), Expect = 0.000e+0 Identity = 2372/2372 (100.00%), Postives = 2372/2372 (100.00%), Query Frame = 2
Query: 26 MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXXXXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATERVSFLEKQLQSFSEQFGVAIDLGY 7141
MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDIKKLKIIKEELEKENAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLKNQKDQNQDSNKSELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQKEIEKLEDERLLLKKKVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDNLEGRNEELRNELRNSRIGFQQLQLDHDKLKQRLKVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWNEAEKRNKELEEKLTELTNHNLELQKIERELRDELIDSVSKEINDAEKRRVLELEKRELEGKHEIEKLKEIAEIATMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKLLRERLSAEAAAGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLKETEIKTENEIIDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRLQDKLKEKLQDKENDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADLKLELAALKEQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATERVSFLEKQLQSFSEQFGVAIDLGY
Sbjct: 1 MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDIKKLKIIKEELEKENAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLKNQKDQNQDSNKSELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQKEIEKLEDERLLLKKKVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDNLEGRNEELRNELRNSRIGFQQLQLDHDKLKQRLKVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWNEAEKRNKELEEKLTELTNHNLELQKIERELRDELIDSVSKEINDAEKRRVLELEKRELEGKHEIEKLKEIAEIATMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKLLRERLSAEAAAGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLKETEIKTENEIIDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRLQDKLKEKLQDKENDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADLKLELAALKEQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATERVSFLEKQLQSFSEQFGVAIDLGY 2372
BLAST of NPHP6 vs. TrEMBL
Match: A0A1S3JQI2 (centrosomal protein of 290 kDa OS=Lingula unguis OX=7574 GN=LOC106175240 PE=4 SV=1) HSP 1 Score: 1067.37 bits (2759), Expect = 0.000e+0 Identity = 772/2084 (37.04%), Postives = 1274/2084 (61.13%), Query Frame = 2
Query: 665 ELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNW---SAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVM----DPMVMMENGWN--LEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNG-QL---PMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSS--NDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQD-------SQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRS-DTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVIT----------LEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSA-STMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRI 6814
+L + D ++ LE A +++R T EY +K+ +D L + E +L+ Q+ L EQ+ + DADD+IM+ VN +V++WK +M ++D EI EE A+LR LQ + +++EKA+V L K V++R+++++ L Q+L A IE N + E+LK +L++TGGG S QM +IKEL+ L +E ++ R + E +++Q+L +ALE+ K YE G +GL EAV +IK K QL VK+R+ + Q++NK ++ EN +R K + + +D+ +R + +E+RA+N+VLQKE+E LE+ER+ LKK+VR LA+Q G RA + G++A D+M +E+ + ++ A Y + +I+ +++ E + VK ++ + T+ + EN + +++I + L +N S G V+ECP LD++L A+E +++ G++DT ++LK ++DNL+GRN+ELR ELR +R F+ + + K +V D V+ E G + + + LPE ++ +++ IA+LN+HL+ +QE SLKE+ ++K + +L+ ++RKFA +RH+QGL+Y++Y EK+ +E++ + L+ LK+ EGI SED R+ EFDR+LDTL++DD E++RRLAD+ R+ITVL+VNE ALTRRY++MQE+E +R+E NKLK+EM+ +E VT+R+GY +R+K+ A +K+ LQK L++SVP ++ +++++TEKYR+ LEK N L+ + ES +E E+ +++ +++ LKK +E EK++ H LE ++E+ +Q I T D+ ++S+SKK+ TLEMK++NE++RA+HAVRMYE K E+RN +LE+K ELT N+E Q++ERELRDEL + V++ +++A++++V EL + E K+E+ +LKEIAE+ TMQ A + QQ+SREKE SLRQQLADIQ QSDEK++IGKLHRHIV LQ+SE +A+RKL + K+L+AQLLR +Q DE+DQ LY +R + + KHL+ TI LR QFSG++PLSR E+F +++L EDK +++ L+ + D+E + + + EL ++ + + V+E W SKME LRLE LK KR ++ + + E++ K QE +A+++E+ + ++ +DD+QLLWEQRE ELER I ++E Q E+ AA+ F++AT G LPDPS P+ NQL+QA+ TIK++++ I + + ++K L++ E E+ +RE E ++ R++ I ELR+RLPA+ R + + + A + L +Y ++ + AQ+T+ LQ R+ KDE++ +Y+ LL++ RED+ +KH +E+KLL+++L ++ + QL P T + TS Q NEL D +A Q + +L + Q+ K K+E + K + + ++ + LKE + ++ E+E ++E QE+ K R+P MKN + +L QL KEKQ Q L L +++ + Q+ + ++ E A + N+Q+V++K+T++L +++E Q+ + +REL+ R + + E++ LK D +E KLK K KLE + +EL + +R+ ++ + D + EL+ ++ K+RL+E+E + K+ K K + S + V WEE K+ Q+ D+LK +L++KE ++ + + D T ALDR R+K+++E+RL G + P+ RS +++LRR+N ELE+++ L R + A +E ++RN+ L +E+LER+L + T +KE+++QK+++RL+ +N+EL+FEAE A K+IPRLKE++ D ++++++LKSE +L +SA S+ NIK++G+SGKST+ELEK I +KKVVE+ Q ENE LK+APG++ NE++Q+L EN LK +L L++++G L ERY + ++G A++++DYE+LRKDL +E + +EK RI
Sbjct: 230 DLQVKADEMRFKLEDAVRQMDRTTDEYMKLKTVLNQSDHALDQYKRENEILKAQVVDLTEQVQSKTDADDEIMVAVNNKVQEWKSVMADKDEEIAEYQEELARLREQLQAAKMDTEKASVSVLSKAVEQRDRQIELLQQKLDQAVADIETNTAVTEDLKGELKKTGGGPSDRQMAKIKELQTTLRIREDHNKDAEIRAEQAEKDAREKDQQLNEALEKMKQYEEGTYGLKEAVDDIKDLKHQLNVKDRQIMELTQHINKCELKINDVCDENEAVRRKAGLEAKD-IDLSEFREARKLRQQEDRAMNVVLQKEVESLEEERIELKKQVRKLAQQTGQRAVALGLDADDMM------AIENYTEELKQRHKTGGTA-AYIKQEAETDELKIRNVQLAQETESNVKALEKARQQLVEYRTKLNAAEDENKKLEQGMKEILQALKEQNEDKESRGEQPTVIECPTLDRMLAALEAKQMKGQYDTSLHLKAQVDNLQGRNDELRRELREAR--FEANKARSEAEKTLERVTKLQNDIKVLQEAGAGAGMLQTLALPEGMAPTSADVIASLNEHLVQTIQELSLKEEMINKMEASLETFKRKFAVMRHQQGLVYQEYIQEKKTWEEDKQKLENDLKNSEGIHSEDKVRLQEFDRLLDTLSKDDIEVRRRLADMTRKITVLRVNEKALTRRYNSMQEVEGYLRKEGNKLKNEMVAMETAVTERLGYLQRYKDMAAFKIASLQKALEDSVPMSELELANKQYNDLTEKYRDLLEKGNTLVAQSESTAGLELEIKRLQHENDGLKKEMEIEKEKLHTLEGAMDEM-----RKQGIPGTGAIS---------DAGIVSLSKKITTLEMKELNERQRAEHAVRMYEQQKGALRGMEERNADLEQKFAELTKMNIEAQRVERELRDELANCVTRAVSEADRKKVAELSQSEAFLKNEVSRLKEIAEVGTMQAQAYEAQQVSREKELLSLRQQLADIQAQSDEKTIIGKLHRHIVQLQVSEGTAVRKLLQAEKKIKKLDAQLLRLQQRLDERDQTLYHSRQEANNKSKHLKRTIQELRRQFSGAVPLSRQEKFAKAMVQLHEDKSEIECRLREVNEQRQDVEDKLAELELQHKGLQELMASIKDGKGAQKVVE-WHSKMESLRLEDLKQKRMITKMQEQARYFENLNKNQEKTIAELEEENVKTSKYYDDRQLLWEQREVELERIIASMEKQQAEIAGAASKFEEAT--------GALPDPSLPVANQLEQAITTIKQNVKTILETQVQHKQLKQKVLELEHALREAESNVISRDKVIAELRVRLPATAGRDEMILHATAKATEAAL---AEDYETKQALKVAQSTIGSLQARIAQKDETIQKYQDLLRQVREDMQDMGKKHEQEMKLLQDKLHSKNDDAFSKFKQTAMQLINKPQDT--LPTSKQLARLNELEDTVAEQDNAMAAMTEKLKAAREQIERWKLKLEDSVKTMTQEKERMLDEHQSMVAQLKEQLERYVERVAEQEKEMEVLQQELITQKDANARAPTTAMKNLVERLKNQLAAKEKQQQALSKALTELRADMVSQAQEQVKSHAEEAAVEINVQRVVEKNTKELKDQIEDLESQLQRAKRELKKRREKETALNTEIEELKEDLTKRESQVTKLKETKLKLEHDVEELEKRAERLSASKSQKTVEPDGRQLELEELRRKIRLLEDELKR-KQQAEKPYEVKAELEPRVMKSDDTVARWEESKKWQKTVDRLKARLKEKEEEVDRMQRHADLTKNALDRANRDKESLESRLK---ATGK-------------------STVVPTGRSTHNLEELRRKNYELEEQVADLKRQITQG-----RDAAFEEVQLRNKFLTEKLEELERQLARRTLTGQAPGPESQAYQQLYDKEQSLQKQVIRLSEENIELRFEAEQAAKDIPRLKERIEDLQRYVEVLKSE----------NLNTSARSSGGNIKKIGESGKSTRELEKTIALLKKVVERVQAENETLKKAPGIVSNEELQMLARENEGLKDQLEELRQKMGATLTERYSSAQKGTAKIMTDYERLRKDLKKETDLNEKLRI 2237
BLAST of NPHP6 vs. TrEMBL
Match: A0A2C9KBV3 (CEP209_CC5 domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106076710 PE=4 SV=1) HSP 1 Score: 1047.73 bits (2708), Expect = 0.000e+0 Identity = 772/2108 (36.62%), Postives = 1284/2108 (60.91%), Query Frame = 2
Query: 668 LHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMAD-----REQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGD---VMDAYKALELESSMQNIEYDP--VMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAG-----VPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVM--DPMVMMENGWN--LEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEEL---GEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKS--NYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXG------TRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQ--------------EISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMK-QELDAMKIKLRLIEEE-NNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDT-VDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVIT-------LEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQM 6829
L + + L+ NLE A +++R + +Y +K+ +D + E +L+ Q++ L EQ+ + +ADD IM+ VN++V++W++IM+E+D ++ L +E KL+ L + ++S+KA+V AL +++K++++++ +L++++ +E+N LIE+L +L + G +++E + ++ K+LRE +++ + EN+ AD +++EL++ LER + YE GE+GLAEAV EIK K Q++++ERE E+ Q +NKA EL EN LR KL + +D+ +R+ KA EE +A+N LQ+EIE LE+ER+ KKK+R LA+Q G RA + G+ A D V D + L+ + +Q + +++ +K ES +G W +E +EL E ++A+L +N+QL +N+ + +++ + L + + G G PV++ P ++++L A+E +K+LG +DT +LK ++D L+GRNEELRN LR R+ + L+ DK ++++ + D + E G + + + LPE ++ S+S+ IA LN+HLII LQE S +E + K + A +NY+RK+A LRH+QG+LY++Y EK +++++E +LK+++G R ED RI EFDR++DTL+ DD E++RRL+++ R+ITVL+VNE ALTRR++ M+E+E +RRE + ++EM Q+EA V++R+GY +R+K+ A +K+ LQK L++SVP D+ K+ ++ +TEKYR+ LEK N L+ + E++ +E E+ ++ D+E LKK LE EK++ H LEA +EEL G A SE S+ D +IS+SKK+ LEMK++NE++RA+HA MY+ + +E E RNKELEEK E+T NLE+QKIER++RDEL +SV+K I+DA+++R+ LE+ EL K EI KLKE+AEIA+ Q L+ Q ++REKE SLRQQL D Q QSDEK++IGKLHRHIV LQ+SE SA+++L++ + +LEAQ+LR EQ DEKDQ +Y TR + + + ++LR+++ LR QF+G++PLS+ E+F+ ++++L +DK KL+++L+ + K ++E + ++ + + EL + R + V E W SK++G+RL+ LK +R C L+ +V +LE +I E +++++ D R+ +D+++KQ+ WE RE ELERTI+ +E E+ AA+ F+ A +G+LP P+ NQL+QA++TIK +++VI D + ENK+L+ +E E +R+ E +L+R++ I+ELRLR+PA+ DR + Q ++ AE +Y ++ + AQ+T+ LQ+R+ KDE++ +Y LLK+ RED+V NQ+H EE++ ++ ++ R N Q +++ T+ Q NEL D +A Q T L ++ KQK E K++ S L ++E L E + + +KES+IE ++ E++ LK R P MKN + +L QL KEKQ Q L L D++ + Q+ ++ N+ + + NIQK++++HT+ +S++LE + + ++EL+ + ++ +Q EL+ +K + + KE T +KLK K++LE E DEL ++++I R+L + + K QELD M+ K R +E++ + QL ++ QE WEE K+ QR +K+K K+++++ +I L+ ++ L+R REK+ ++ L K +L A P + D +DL+ +L+ EI L A S + AL E +MRN+ L+ +E +ER + S S ++ K + +Q++++RLN +N+EL+FE E++RK+IPRLKE+V D + +++ LK E L G S R S++S+IKR+G+SGKS +ELEK I +KKVVE+ Q EN LK+APGV+ EQ+ LL+ EN LK +L L++ +G +L+ERY A+++G A++V+D++KLRK+L +E +E+EK R+ ++ +
Sbjct: 224 LQKRCEDLQRNLEEAITQMDRTSEDYLKLKNVLQQSDAVTDALREENELLKNQVQDLSEQVRSKGEADDAIMVAVNQKVDEWQEIMQEKDIQMVNLQDEIFKLKSQLIAANMDSDKASVSALSEVLKDKDKQIAELTEKVDQYTIEMEKNAALIEDLNNELHKAGSSQGDRMQTKVREFQ----NENKLLRERLQQ-AEAENKKADQDCRVKDKELSELLERMRQYEAGEYGLAEAVNEIKEGKNQVKIREREIEELTQYINKAELKINELLDENEELRYKLGMDPKAPMDLTEFRKNKAIRQEEMKALNFTLQREIEMLEEERVADKKKIRKLAQQLGQRAVALGLTAEDMLAVQDYTETLKAKRQVQEEQQSAAVIIRQQVQKEESMIRGKE-WDKDYKENVAELHKL-------EVQVAELRAQNQQLNKDNENLEAGFKEVMQAL-QKGATEGQGDVDSSAPVMQFPAIERMLAAIEAKKVLGNYDTTYFLKEQMDILKGRNEELRNTLREIRVEVTKTSLERDKAFEKIEKLEKDHFMFSEAGAGPGMFQFMKLPEGMAPSSSEVIAHLNEHLIITLQELSQREGVMKKTEAAFENYKRKYAVLRHQQGMLYQEYLKEKSVWQEDMEKYSKQLKELQGQREEDLVRIQEFDRLVDTLSTDDVEVRRRLSEMTRRITVLRVNEKALTRRHAIMEEIETQLRREVERQRNEMGQMEAAVSERIGYLQRYKDMAAFKIAALQKALEDSVPSADLEKVNKQYHNLTEKYRDMLEKGNTLVSKAEALEGLEGEIKQLTADNEVLKKTLEMEKEKLHALEAAMEELHRRGVASGSEVSV---------------TDGDIISISKKITMLEMKELNERQRAEHASHMYQQQRQILHEMESRNKELEEKFAEVTKMNLEMQKIERDMRDELSNSVTKSISDADRKRISVLEETELTLKQEISKLKEMAEIASTQVRTLETQHIAREKEYQSLRQQLLDFQVQSDEKTIIGKLHRHIVQLQVSEGSAIKRLEEAQKKVTKLEAQMLRQEQRVDEKDQTIYHTRQEAQGKARYLRKSLQELRIQFAGAVPLSKQEKFSRSMMQLQQDKAKLEKDLKESREHKNEMEDKLAALSLQQNSLQELIAVLKDGRGAQKVAE-WHSKIDGIRLDELKQRRMCAKLQQKVRYLEEIITSHEVTISELEADNVRMMKDYEEKQMRWELRETELERTIITMEKHTAEIAGAASKFELA--------VGSLPSAKLPVANQLEQAISTIKGNVKVILDTQAENKSLKARNQELEKLLRDSERGILERDKLISELRLRMPATADRDDIIIQAQAKVTQAIKKAETGGIDYESQQALKIAQSTVHSLQQRINQKDETIAKYMILLKQGREDMVQMNQRHEEELRAMQHKIHMNTDLAFSKFKEAARELINKQ---SSSKTVTAQQLSRLNELEDTVAEQENTISALHEKI----------KQKEEEILKLHAS-LSIFNRNLKSEQTRLAEQHGEI---VGKKESEIEMVSRENEDLRKEVKLLQDEVAALKDVNQRGPTATMKNMVERLKNQLALKEKQHQALSKALTDLRADMVSQA----QVLANDASQEKNIQKIINEHTKQISDQLEDQQTLADRLKKELKKKKDEEGALQTELEDVKEELNKKERTIEKLKASKARLESEVDELEKKMEKITAARSLKAGEFEKQQELDDMRRKCRALEDQLSRQLAAEKPYEQKEEKTKQEDTIRWEESKKWQRTIEKMKVKIKERDKEIETLNGTVNRLKALLERTNREKE-IQAPLIQKTSAVSL-------------------SAAPGGKLDHEREDLKATIYKLQDEIRTLKHQALMS-----QDAALAEVQMRNQHLREQLEQMERAMAARPSDSGVSAAEYQKLFLKNQELQRDVLRLNEENIELRFEVESSRKDIPRLKERVQDLQSYVEALKFENGQLTGDSAR------SSLSSIKRIGESGKSQRELEKTIALLKKVVERVQAENTALKKAPGVVSQEQLNLLKRENDGLKSQLEELRQTMGLELSERYTAQQKGTAKMVNDFDKLRKELAKEKDENEKLRMKIRSL 2241
BLAST of NPHP6 vs. TrEMBL
Match: A0A1I8I494 (CEP209_CC5 domain-containing protein OS=Macrostomum lignano OX=282301 PE=4 SV=1) HSP 1 Score: 1046.19 bits (2704), Expect = 0.000e+0 Identity = 839/2359 (35.57%), Postives = 1345/2359 (57.02%), Query Frame = 2
Query: 53 LKVKTDQLNSMSPD--DIDIIYELMVNIDDISNVDDADKLY-----KAFNIAQFIMSYKAEENKGLNEDLEEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXXXXELAYTRSELRQK----KIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKEL-------RQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVM------DAYKALELESSMQNIEYDPVM--QSMARKYESA----------PQGNNTWR-----IKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDP-MVMMENGWNLEERI---GLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHL-----ISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEK-SNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRR------AGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSND-AMKQELDAMKIKLRLIEEENNQLKRNPAKSANS-----------KQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRN----ADSSDSKTV-NNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG 6904
+K DQ+N P D+D E+++N+ D + D+ K+ K Q + +EN+ L E D K +++++ E E ES+ +IR+ + + LT +N+ E N ++++ ++ N LS + L++R ++ E Y S+L QK K DLD A + EL ++++ +++ L E E + Y++MK+ D + + + +LR Q++ LQ+++ DD IM VNE+VE+W++ + ++D E+ R +E +LR L +++ K + L + ++ER+ + +L Q+L + ++E + D +G Q RI +L +Q L++ + E+ K ++ ++ +EL + RN G FGL EAV E KA + +L+ R E Y++ +NK + A+ L+ EN +R +L I DE LD +RR KA + EE+ A +VLQKEIE LEDER+ LK +V+ LA+Q G +A G+ +G++M +A +A + S + + P M +MA S P+ T R + + ELS A +E +E ++ +L T+N L EN M AL++IK+ + N AG+ LECP LDK L A+E +K++G+ D YLKTR+D+L+GR +E+R ELR SR +L DK + + + + M+ N + I LPEN++ ++ + I +L + L+ L E +++ + K D++L ++R KFA RH+Q LLY ++ E+ + +E L RL +++G R ED AR++EFDR+LDTL Q E RR+ + RQ+T+L+ NE AL RR++A+QE E+T+RREN +LKSE ++E VT+R+GYYRRFKETA +K+N LQK L + VPR D+ +LQ K DE+TEKYR+FLEK N L+ + E++ +E EL ++++D+E LKK L EK++RH+LEAT+EEL SK VD+ + ++MSKK++ LEMK++NE+ERADHA +MYE+ K + + RN+ELEEK ELT LE QK ERELRD L V+KE +D +++R+ LE+ EL+ K E+E+L+E+++IA Q+ ++QQ+S+EKE SLRQQL D QCQSDE+++IG+LHRHIV LQ+SET+ALRKL+D +R EAQ+LR EQ DE+D+ L Q RL+ R+R K LRET++SLRSQF+G +PL++ ERFT TL+ L EDK++ + L + E E ++T+ EL +A+ T K V E W +ME LRL+ L+ +R C+ R +V+HLE V++ QE+ + Q++ED R+++D++++QLLWEQRE ELER + +E+ E+ A +AT + +PD PLP QL+QA+ATIK+ I+ IFD E+ENK L+ +E E ++E E L+K+ER INELRLRLPA+ DR +Q + A + +A N+V+ KT+ AAQTT++ LQ RL+ K+ESL +Y++LLK A++DL + ++H EE K+LRE+LS + R+ + G+LP + T ++ +EL++LLA + + L+ +L + + ++ K +T K + + + + E E + K+++ EK + ++ +++ R K + R P+ MKN + KL QL +KEKQ + L L D++ + + + + + + ++ ++L++HT+++++ELE +++ + + E R R +KE + + LKA+ K+ TA KL+T+K+++EQE +E++ +++RIK R D K E++ ++ K+RL+EEEN + ++ P K S + WEE KR +R DKLK+KL K+ + L +Q + T ALDR + + Q +A T S D+R +N +LE+E+ RL D + + + V++ E Q +E E S V + EK++ ++ ++ L +N +L FE + AR+++PRLKE+V K+++LLK EK LE N + SS S+ SNI+R+G+SGKST+ELE+MI R+K VV++T+ ENERLK APGV+ E +Q LR EN L+ +L+ L+EQ+G +LAERY+AKERG A+++ DYEKLR++L RE + H++TR + ++ R++ + + + S LA ++ RG
Sbjct: 20 VKSIVDQINDFDPGNMDVDGEAEMVLNLYDA--IIDSQKMAHERMEKQTTDLQIALDDLEKENQRLRRTAREGGADADK---------------------ELDLLNENERLNKEVESLQSDIRKKEQDISKLTGENEDLENKRNSLEQKLSEVESENRSLSSRLTTLQERIDR---------TEKSQETKYAISDLNQKVRQLKTDLDLALQGKAELQEKLEKVQKELLDGAAEYESFCARYQDMKAYVDEKDTEAANATGQIEVLRQQVQELQDEIAMLRRDDDNIMNAVNEKVEEWRKHLADKDDELRRAEQEVRELRSRLGALSVDASKEQLAKLQQRLQERDTTIDELRQELSEGTDECNRVKAMLEQFQLDQAASGNTMVSRQADRIGQLLKENQGLKQRLEEGHQQALES----EKASRELEEKNEELVN---RNDQIVAGVFGLKEAVDETKAKERELEYCRRMIEDYVRQINKLHDDADNLRIENSMMRERLGIAPDEVLDTTAHRRAKAVQQEEDSATIMVLQKEIESLEDERMRLKWQVKSLAKQCGGQAAQMGL-SGNLMVLESFVEAERAGGVHSGIDEM-IQPRMAGSAMAAAPGSTMLSSRGGILEPETARTGRSVAGGAEAAGLRQELSRAAREFEEQEKKVCQLQTQNENLSEENRVMESALKEIKDGM--ENRKAGS----LECPSLDKFLAALEAKKVMGDIDASSYLKTRLDHLQGRYDEVRAELRESRAETAANKLQLDKTRALSERLQADLDMVRNVGAASKTIFSLNLPENMTQTSQEVINSLTEQLVQALAEAKKRKEEVSKLDQSLQHFRAKFAVARHQQSLLYAEHLRERTSWSEEKTRLNQRLDELKGERQEDAARLSEFDRLLDTLAQKPEEQARRMVETTRQVTLLRCNEAALVRRFTALQEAEKTLRRENGRLKSEFTEMEKAVTERLGYYRRFKETAAFKVNSLQKALADCVPRDDLDRLQRKLDELTEKYRDFLEKNNSLVHKAETLDTMEMELRQLRLDNETLKKALTVEKEKRHLLEATMEEL---------------------SKRGVDTGVTEQSQVAMSKKLSMLEMKELNERERADHASQMYESQKLQLQQLDARNRELEEKFAELTTRVLEAQKTERELRDSLATCVTKEASDRDRQRISTLEEAELKLKQEVERLRELSDIALSQSKTFREQQVSQEKELTSLRQQLLDFQCQSDERAVIGRLHRHIVQLQLSETTALRKLEDAFAKSRRSEAQMLRLEQRVDERDETLSQHRLECRSRTKQLRETVSSLRSQFAGCVPLAKQERFTKTLLALQEDKLRTKRLLTEAEEQRAKAEDELLAMKTRQETQAELHEALRTGTGAKKVAE-WHQRMEQLRLQELQQRRACERARQQVKHLEGVVRSQEALIGQLEEDAVRLSKDYEERQLLWEQREAELERVVTRMESAGSEIAGTAKRLGEATAS-------DVPDRELPLPLQLEQAVATIKQKIKAIFDLESENKQLKSQMRELEETLKERERALIKKERAINELRLRLPATADRDRQFAAAAAEADAAAASANPMENFVEAKTLHAAQTTVASLQARLQQKEESLAKYKELLKGAQDDLETAVRRHNEEAKMLREKLSQKEELVMRQTAAQQGSAATGELPRESV---TRKHLKKLHELQELLAHERGKSAGLESELREARREMETWKLSYDTAHKGFDAERAVLKEELDEEKRRCTEEVARAKQEVVEKSALVQQLREDLRRQKSENERGPSATMKNLVRKLEMQLEEKEKQQRALSKALTDLRADMVYHAEETAKAGGVQNEQERDLHRILERHTKEIADELELTKERAFRVKSEQRKLREEKEAAVQQCEELKAEVARKDATAAKLRTEKNRMEQEMEEMQKKMERIKAARRSGGADEQTKTEMEELRRKVRLLEEENVRFRQRPEKPFESDIGLSGGRGFGGGGRSGGIEEWEERKRLERTIDKLKDKLGQKQIEFDRLQRQYELTKNALDRSTGGGGGSRHGPPGR------------------QESVSVARLTGSRLQIADADVREKNFQLEEEVSRLRYQLHTLGDEREKEALRRQVSMLEERTEELERQLRLEKPE------FSVEVERMREKQRRLETQLTGLTRENTDLTFEVDQARRDLPRLKERVAHLTKYVELLKQEKAQLEAAGN-TARSSTSSTSNIRRIGESGKSTRELEEMIARLKNVVKRTEAENERLKRAPGVVSQEALQQLRQENDGLRQQLSELREQMGSRLAERYEAKERGTAKLMQDYEKLRRELQRECQSHDRTREEAARLQRELSEAGRGDT-AASTLATAQFRG 2273
BLAST of NPHP6 vs. TrEMBL
Match: A0A267E763 (CEP209_CC5 domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig006149g4 PE=4 SV=1) HSP 1 Score: 1042.34 bits (2694), Expect = 0.000e+0 Identity = 838/2359 (35.52%), Postives = 1344/2359 (56.97%), Query Frame = 2
Query: 53 LKVKTDQLNSMSPD--DIDIIYELMVNIDDISNVDDADKLY-----KAFNIAQFIMSYKAEENKGLNEDLEEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXXXXELAYTRSELRQK----KIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKEL-------RQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVM------DAYKALELESSMQNIEYDPVM--QSMARKYESA----------PQGNNTWR-----IKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDP-MVMMENGWNLEERI---GLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHL-----ISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEK-SNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRR------AGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSND-AMKQELDAMKIKLRLIEEENNQLKRNPAKSANS-----------KQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRN----ADSSDSKTV-NNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITL-EKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG 6904
+K DQ+N P D+D E+++N+ D + D+ K+ K Q + +EN+ L E D K +++++ E E ES+ +IR+ + + LT +N+ E N ++++ ++ N LS + L++R ++ E Y S+L QK K DLD A + EL ++++ +++ L E E + Y++MK+ D + + + +LR Q++ LQ+++ DD IM VNE+VE+W++ + ++D E+ R +E +LR L +++ K + L + ++ER+ + +L Q+L + ++E + D +G Q RI +L +Q L++ + E+ K ++ ++ +EL + RN G FGL EAV E KA + +L+ R E Y++ +NK + A+ L+ EN +R +L I DE LD +RR KA + EE+ A +VLQKEIE LEDER+ LK +V+ LA+Q G +A G+ +G++M +A +A + S + + P M +MA S P+ T R + + ELS A +E +E ++ +L T+N L EN M AL++IK+ + N AG+ LECP LDK L A+E +K++G+ D YLKTR+D+L+GR +E+R ELR SR +L DK + + + + M+ N + I LPEN++ ++ + I +L + L+ L E +++ + K D++L ++R KFA RH+Q LLY ++ E+ + +E L RL +++G R ED AR++EFDR+LDTL Q E RR+ + RQ+T+L+ NE AL RR++A+QE E+T+RREN +LKSE ++E VT+R+GYYRRFKETA +K+N LQK L + VPR D+ +LQ K DE+TEKYR+FLEK N L+ + E++ +E EL ++++D+E LKK L EK++RH+LEAT+EEL SK VD+ + ++MSKK++ LEMK++NE+ERADHA +MYE+ K + + RN+ELEEK ELT LE QK ERELRD L V+KE +D +++R+ LE+ EL+ K E+E+L+E+++IA Q+ ++QQ+S+EKE SLRQQL D QCQSDE+++IG+LHRHIV LQ+SET+ALRKL+D +R EAQ+LR EQ DE+D+ L Q RL+ R+R K LRET++SLRSQF+G +PL++ ERFT TL+ L EDK++ + L + E E ++T+ EL +A+ T K V E W +ME LRL+ L+ +R C+ R +V+HLE V++ QE+ + Q++ED R+++D++++QLLWEQRE ELER + +E+ E+ A +AT + +PD PLP QL+QA+ATIK+ I+ IFD E+ENK L+ +E E ++E E L+K+ER INELRLRLPA+ DR +Q + A + +A N+V+ KT+ AAQTT++ LQ RL+ K+ESL +Y++LLK A++DL + ++H EE K+LRE+LS + R+ + G+LP + T ++ +EL++LLA + + L+ +L + + ++ K +T K + + + + E + K+++ EK + ++ +++ R K + R P+ MKN + KL QL +KEKQ + L L D++ + + + + + + ++ ++L++HT+++++ELE +++ + + E R R +KE + + LKA+ K+ TA KL+T+K+++EQE +E++ +++RIK R D K E++ ++ K+RL+EEEN + ++ P K S + WEE KR +R DKLK+KL K+ + L +Q + T ALDR + + Q +A T S D+R +N +LE+E+ RL D + + + V++ E Q +E E S V + EK++ ++ ++ L +N +L FE + AR+++PRLKE+V K+++LLK EK LE N + SS S+ SNI+R+G+SGKST+ELE+MI R+K VV++T+ ENERLK APGV+ E +Q LR EN L+ +L+ L+EQ+G +LAERY+AKERG A+++ DYEKLR++L RE + H++TR + ++ R++ + + + S LA ++ RG
Sbjct: 24 VKSIVDQINDFDPGNMDVDGEAEMVLNLYDA--IIDSQKMAHERMEKQTTDLQIALDDLEKENQRLRRTAREGGADADK---------------------ELDLLNENERLNKEVESLQSDIRKKEQDISKLTGENEDLENKRNSLEQKLSEVESENRSLSSRLTTLQERIDR---------TEKSQETKYAISDLNQKVRQLKTDLDLALQGKAELQEKLEKVQKELLDGAAEYESFCARYQDMKAYVDEKDTEAANATGQIEVLRQQVQELQDEIAMLRRDDDNIMNAVNEKVEEWRKHLADKDDELRRAEQEVRELRSRLGALSVDASKEQLAKLQQRLQERDTTIDELRQELSEGTDECNRVKAMLEQFQLDQAASGNTMVSRQADRIGQLLKENQGLKQRLEEGHQQALES----EKASRELEEKNEELVN---RNDQIVAGVFGLKEAVDETKAKERELEYCRRMIEDYVRQINKLHDDADNLRIENSMMRERLGIAPDEVLDTTAHRRAKAVQQEEDSATIMVLQKEIESLEDERMRLKWQVKSLAKQCGGQAAQMGL-SGNLMVLESFVEAERAGGVHSGIDEM-IQPRMAGSAMAAAPGSTMLSSRGGFLEPETARTGRSVAGGAEAAGLRQELSRAAREFEEQEKKVCQLQTQNENLSEENRVMESALKEIKDGM--ENRKAGS----LECPSLDKFLAALEAKKVMGDIDASSYLKTRLDHLQGRYDEVRAELRESRAETAANKLQLDKTRALSERLQADLDMVRNVGAASKTIFSLNLPENMTQTSQEVINSLTEQLVQALAEAKKRKEEVSKLDQSLQHFRAKFAVARHQQSLLYAEHLRERTSWSEEKTRLNQRLDELKGERQEDAARLSEFDRLLDTLAQKPEEQARRMVETTRQVTLLRCNEAALVRRFTALQEAEKTLRRENGRLKSEFTEMEKAVTERLGYYRRFKETAAFKVNSLQKALADCVPRDDLDRLQRKLDELTEKYRDFLEKNNSLVHKAETLDTMEMELRQLRLDNETLKKALTVEKEKRHLLEATMEEL---------------------SKRGVDTGVTEQSQVAMSKKLSMLEMKELNERERADHASQMYESQKLQLQQLDARNRELEEKFAELTTRVLEAQKTERELRDSLATCVTKEASDRDRQRISTLEEAELKLKQEVERLRELSDIALSQSKTFREQQVSQEKELTSLRQQLLDFQCQSDERAVIGRLHRHIVQLQLSETTALRKLEDAFAKSRRSEAQMLRLEQRVDERDETLSQHRLECRSRTKQLRETVSSLRSQFAGCVPLAKLERFTKTLLALQEDKLRTKRLLTEAEEQRAKAEDELLAMKTRQETQAELHEALRTGTGAKKVAE-WHQRMEQLRLQELQQRRACERARQQVKHLEGVVRSQEALIGQLEEDAVRLSKDYEERQLLWEQREAELERVVTRMESAGSEIAGTAKRLGEATAS-------DVPDRELPLPLQLEQAVATIKQKIKAIFDLESENKQLKSQMRELEETLKERERALIKKERAINELRLRLPATADRDRQFAAAAAEADAAAASANPMENFVEAKTLHAAQTTVASLQARLQQKEESLAKYKELLKGAQDDLETAVRRHNEEAKMLREKLSQKEELVMRQTAAQQGSAATGELPRESV---TRKHLKKLHELQELLAHERGKSAGLESELREARREMETWKLSYDTAHKGFDAERAVLKEELDEEKRRCTVEVARAKQEVVEKSALVQQLREDLRRQKSENERGPSATMKNLVRKLEMQLEEKEKQQRALSKALTDLRADMVYHAEETAKAGGVQNEQERDLHRILERHTKEIADELELTKERAFRVKSEQRKLREEKEAAVQQCEELKAEVARKDATAAKLRTEKNRMEQEMEEMQKKMERIKAARRSGGADEQTKTEMEELRRKVRLLEEENVRFRQRPEKPFESDIGLSGGRGFGGGGRSGGIEEWEERKRLERTIDKLKDKLGQKQIEFDRLQRQYELTKNALDRSTGGGGGSRHGPPGR------------------QESVSVARLTGSRLQIADADVREKNFQLEEEVSRLRYQLHTLGDEREKEALRRQVSMLEERTEELERQLRLEKPE------FSVEVERMREKQRQLETQLTGLTRENTDLTFEVDQARRDLPRLKERVAHLTKYVELLKQEKAQLEAAGN-TARSSTSSTSNIRRIGESGKSTRELEEMIARLKNVVKRTEAENERLKRAPGVVSQEALQQLRQENDGLRQQLSELREQMGSRLAERYEAKERGTAKLMQDYEKLRRELQRECQSHDRTREEAARLQRELSEAGRGDT-AASTLATAQFRG 2277
BLAST of NPHP6 vs. Ensembl Cavefish
Match: cep290 (centrosomal protein 290 [Source:NCBI gene;Acc:560588]) HSP 1 Score: 759.599 bits (1960), Expect = 0.000e+0 Identity = 673/2149 (31.32%), Postives = 1197/2149 (55.70%), Query Frame = 2
Query: 818 RMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAY--KALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDP---MVMMENGWNLEER-IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLE---ELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELK-----DAMATKRNEKSV--LESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPM--ATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKN-LRNLSSNDAMKQELDAMKIKLRLIEEE-NNQLKRNPAKSANSKQD---SQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRL-MRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRL--------TQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRG------------RQNVSRIANKELQDENRKLS---SIIANLQSQLKDKHNQNPDSSKV-----EELKLLYNKATERVS--FLEKQLQS 7102
R + L EQ+ R + DD +M V+ +VE+WK ++ E+D EI + LR L+ + ++S+K+N+ AL + V+ER+ ++K LS ++ +E+N LIE LKK +++ G S Q+R+++EL+ L E+ +++ + E ++++EL+++L R ++YE G GL A+AEI+ CK Q+++++RE E + +N+ +L EN LR KL + E++D+ +RR KA + + RA N VL KEIE+LE+ERL LK+ +R L + G D+ Y + L S +QN EY + ++L++ KE +K+ E ++L R + Q EN + +++I + + ++ S + + + P L++L+ A+E + G+ D G +L+ ++D L RNEEL+ EL+ +R K ++ ++ V + G + ++ + LPE ++S+ +TI +LN++++ +LQE K+ AL+ Y+RKFA +RH+QGLLY++Y EK+ +++E + +E + D +I E++ L+ L +D E++R++++ R++TVL+VNE +LTR+Y+ + E EQ +R+ENNKLK + +Q+E VT R+GY +RFKE A +K+ LQK LD+SVP ++ + +++++T KYR+ L+K N L+ R + +E+E + ++ K LE K++ H LE E ++GE + +++K+ +N S ++S+SK++ TLEMK++NE++RA+HA +MYE+++N+ + E+RN ELE + E+ NLE Q+IERELRDEL DSVSKE++DA+++ + ELEK E + + E+ KL+E++++A MQ +AL+ ++ SREKE SLR+Q+ D Q QSDEKSLI KLH+HIV LQ+SET+A+ KL+ +LEAQ LR EQ+ D + Q L+ R +GR R +HLR + +LR+QFSG++PL++ E+F++T+++L E + K ++ Q ++ E ++A R E EL+ + MAT ++ K + W K+E RL+ L+ R+ R E+ +L+++I QE ++ ++E++ + +++QL W+ RE ELER + + Q ++I +A F++AT +LPDPS PL +QL QA++ IK+H+R I + + K L + K E + + E +L R+R INELRLRLPA+ +R + + +S ++ + + + A T+S LQ RL K+E L +Y+ LL +AR++ +++KH EE++ L ++L Q M T V T+ Q EL +A Q + L +L + +L Q+Q + K + ++ + E + +++ + + + ++++ E ++++ E+ K RSP+ MKN + +L QL KEKQ + L L +++ +T + + + + NIQ+++DK T+DL ++ +++ ++ +R+A++ + ++ EL+ L + + + +L++++ LE++ +EL+ +++R+ + L+ + ++ ++ ++ K+R +E E + + PA+ +D S+E++ WEE K+ Q +K + L++KE LSKQL+T + R+ +EK ++ +L + G D + A ++ L+ RN ELE++I+ + ++ A D+ A+++ +RNR L+ I LE +L + SG S ++E +QK+ +RL+ +NLEL+F+ E A K++PRLK +V+D K+ D+LK EK + + G SGK+ ELEK I MKKVVEK QRENE LK++ EQ+ L E+ K E +KE++ L R D+K +GM ++V + E+L KD+ + +E EK R++ + KL+ + + KL +++S+G V+R+ +++D +LS + I+ +LK+ H + D+ + E+++LL N E ++ L +Q QS
Sbjct: 182 RNPVRELTEQIQSRAEEDDPVMAAVSAKVEEWKNVLSEKDVEIMEYQQMIRDLREKLRAAHLDSDKSNIIALQQAVQERDHQIKLLSARVEQYTGEMEKNALLIEELKKPMKKEKGMGSTLQLRKLEELQAKLQAAERRVQQAEREAHLAEADAHEKDKELSESLSRIRLYEAGTDGLEAAIAEIRECKNQIRLRDRELEVMTKEINQLELKINDLLDENEELREKLGMNPKEEVDLTEFRRTKALKQRQYRAENQVLLKEIERLEEERLELKQHIRTLVKDKG----------KDLFSYYLLTFVFLASFLQN-EY---------------------------LQNQLNSREKELELKKAESSQLKARLNKTQKENQQLEQDMKEILQAIQAQSKSP-SQIGISRIPSLERLISALEIKYSEGKVDIGTHLRFQLDQLTSRNEELKQELKAAREEAASTLSQLMKSSDKVARLESEIEAVRLSAGAAVPQKTLPLPEESASSSVKTINSLNEYMVQLLQENKNKQDHNKMLGLALEEYKRKFAVIRHQQGLLYKEYQSEKESWQKERHSFAELKAKMEEQKEVDAVKIKEYNNWLEALEKDPVEMRRQVSEAARRMTVLRVNEKSLTRQYTTLLEQEQHLRKENNKLKEDFVQMETAVTKRIGYLQRFKEMAAFKMAALQKALDDSVPSFELERANKQYNDLTIKYRDLLQKDNYLVQRTTGLEHMENENVSLHEQINSVNKELEITKEKLHTLEQAWEHINDIGEESSINKAVKALAN------------SEIVSVSKRITTLEMKELNERQRAEHAQKMYEHLRNSLKQVEERNLELEGRFAEMAKQNLEAQRIERELRDELADSVSKEVSDADRQHIAELEKSEAQLRIEVSKLREVSDVAKMQVSALEARRQSREKEVESLRRQVLDYQAQSDEKSLIAKLHQHIVALQLSETAAISKLEASTARLLKLEAQQLRAEQHLDAQQQALWHERQEGRQRARHLRHALQALRTQFSGALPLAQQEKFSNTMLQLQEAQQKARKDAQ-------RIQEEHKMAE-GRAQELELRLKSLEELMATIKDGKGAQKVSEWHKKLEEARLQELRKNRELGAQREEIRYLKNMIDEQERIISSLEEELVQQNNLQEERQLSWDHREVELERQLEAYDKQQRQIIGSAQKFEEAT--------DSLPDPSQPLAHQLGQALSKIKEHVRTILETQAVCKTLEEKLKVKEAALWQAEQNVLARDRVINELRLRLPAAAERERLLADLS----------KQEDLNSQPALKIAHQTISNLQGRLDQKEEVLKKYQNLLVKARQEQEETSKKHDEEVRNLHQKLDLHTDKSLDHFRQTAQELMKKPTITVPTTKQLARLAELEQTVAEQDTSILSLTHKLKMLNAELEKQRQATASQAKDHTAQTAKLEERHASQMKAVSQEAEEHRSQVSQMEKELQYLRTELEAQKAANVRSPSNTMKNLVERLKAQLALKEKQQKALSKALLELRAEMTSHAEQQIIASAAQKEESLNIQQIVDKQTKDLKTHVKELSEELQSWKENVRAAKSRESSLKEELESLSRELQKSQKSQSRLQSERGALEEQVEELKQKVRRLHSGLQGQTESEIKGPSVETLQKKIRKLESELDKKSVSEPAERKTLVKDDKTSKEELVRWEEAKKWQAKVEKFQNHLKEKERQTDLLSKQLNTLKELYGRLEQEKAGLQKKLKSR---GVTAD--------------QVVGARTVETDKEIESLKNRNCELEQQIEIMKLQQALPRDA------AMEDINIRNRYLEERIYSLESQLKKDPFSRPSTSGRGSGTPSQREHELQKDNLRLSTENLELRFQLEQANKDLPRLKHQVSDLKEMCDVLKKEK-----------AEVEKKLGHGHGTGRSGKTVPELEKTIALMKKVVEKVQRENESLKKSSATTTQEQLTTLEREHEKFKAEYDKMKEKMDFHLTSRLDSKMKGMEKIVMENERLHKDIKKVSEALEKLRVENTSLVVKNKKLKAELDETTQKLLLAQSKGPSLERADGKSWKSTVVTRLYENKMKDLESELSKNKASISEFNLKLKESHEREKDAQRTIIQLKEQVELLKNTPIEGITEEGLAQQFQS 2219
BLAST of NPHP6 vs. Ensembl Nematostella
Match: EDO40972 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5V4]) HSP 1 Score: 239.195 bits (609), Expect = 3.031e-69 Identity = 157/398 (39.45%), Postives = 247/398 (62.06%), Query Frame = 2
Query: 3353 QKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRER 4546
Q+IER+LR+EL +V++ ++++ +R+ LE+ E K E +LKE+AE+A Q +L+ QQ +E+E +LR+QL D+Q +SDEK++IGKLH HIV LQ+SE +A+RKL+ + +LEAQ+LR EQ DEKDQ LY ++ + R + K L+ TI LR Q+SG++PL + E+F +T+ L EDK L+++L+ + E + + + EL + + V E W +KM +R++ LK R D ++ + LE++ K E ++ ++DI +T+ H+++QLLWEQRE ELER I E Q EV+ AA F++AT G+LPDPS P+ NQL+ A+ I++HIRVI EN L K +E E +++ E L ++++
Sbjct: 7 QRIERQLREELEGAVTQAMHESVVKRLQVLEESEARLKVEESRLKEVAEVAAHQAESLKSQQDGQERELMALRKQLYDVQMESDEKTIIGKLHHHIVALQVSEGTAVRKLEAATQKVSKLEAQILRLEQKIDEKDQILYHSKTEARNKAKFLKRTIQDLRRQYSGALPLMKQEKFANTMRALHEDKANLERDLRKVTEDRLLAEDKLSELELKHRNLEELIATLKDGKGAAKVTE-WHTKMNEIRIQDLKLNRTIDRMKEQCRFLENLNKQHERTISDYEDDIVEMTKHHEERQLLWEQREVELERMIDRFEKQQSEVMNAAQKFEEAT--------GSLPDPSLPVANQLELAVRKIREHIRVIISTREENNRLGKKVEEAEQALKQSEERLTQKDK 395
BLAST of NPHP6 vs. Ensembl Nematostella
Match: EDO40973 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S5V5]) HSP 1 Score: 115.161 bits (287), Expect = 7.448e-27 Identity = 89/310 (28.71%), Postives = 170/310 (54.84%), Query Frame = 2
Query: 665 ELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRE-TVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL 1591
EL ++D K LE AT E+++I EY +K+ +D L+ E LR Q++ L+ Q++ + DADD+IM+ VN +VE+WK ++ +D EI + + L+ ++ ++++ + L + + E++ +++ L +L E + +++++ G + + E++ D K+ R+ + K E +++EL+D + R YE+GE+GL+EAV EIK KAQLQ++++ E +VNK + A +L+ EN LR +L + ++LD+E ++++ + E+ A+N VL
Sbjct: 78 ELEMKLDESKRELEAATTEMDKIADEYTKLKTILQQSDLILEEMRRERDALRAQVQDLRVQVSSKTDADDEIMMAVNVKVEEWKAVLVAKDIEIEQYKDMVNGLQQRIRGLEMDTDSTTMALLQQAIVEKDDQIQMLKSELEKVGKYQETSFVIVDSMHLQASTEMQGIAAQ----VDEVKSQAD---KVYRKRKIRFFFKAEEAARQKDKELSDLMVRMVQYEKGEYGLSEAVQEIKDHKAQLQIRDQNIESLTASVNKLSLAVNDLEMENEELRERLGMDPRDRLDIEEIKQKRKVKKEQSAALNRVL 380
BLAST of NPHP6 vs. Ensembl Nematostella
Match: EDO29675 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2Z1]) HSP 1 Score: 83.1889 bits (204), Expect = 8.290e-16 Identity = 122/494 (24.70%), Postives = 241/494 (48.79%), Query Frame = 2
Query: 5234 MKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRI-----KNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRN--------PAKSANSKQDSQ---------EKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEA-EMRNRILQRNIEDLERRLTQ------------SGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGV 6610
MK + +L QL KEKQ + L L ++ + + + +++ + + N+Q V++K T L + +E + ++ + +REL+ + + +Q E + LK K+ KL + +L + +L + + + K R S D +++++ +++ +L++ E + P + S +D E+V WEEGK+ Q+ + L+EKL +K ++ K + +A++R ++K +++RL G+ +A R P P D + +L+ + LE+E N D +T+ + EA ++RN LQ ++ LE L+Q +G + +K +++QK+++ +N+EL+F+ E ARKE PRLK +V D ++++++LK+E E+ K ++ + S T G G+S +++E+++ M++VVE+ Q ENE+LK+ G
Sbjct: 1 MKALVERLRNQLALKEKQQKSLSQALLQLRADMVTTAEENVQIHAKKAEQEVNVQHVVEKETSSLQSRIEELQSRMEKLKRELKRQKEKESTLQGEKERLKEQLAQKDSAINKLGVELKELHEIEQKLDGKAEELAAEKRKATRATSEADKLREKVKSLQEQLKVQRAEGEVVAAATVEVEGAVPPSAEISPRDEDRGTKTSKRGEEVARWEEGKKWQKKVETLREKLSEKTKELEKAEKTISMLREAVNRGEKDKTGLQSRLRSAARVGS-----------TAVTRPP-----PD---DFIQELKHKIFTLEEE------NQDLRRQQTLGHDRQMEALQLRNDQLQDAVQSLENELSQRVTEQRSIDQADAGMYRDLH-QKNQSLQKQLLEARQENMELRFDYEQARKENPRLKARVEDLQEYVEILKAELES-SKKREKARKKSLGT-------GLGGQSVEDMERVLAAMRRVVERLQGENEQLKKTAGA 460
BLAST of NPHP6 vs. Ensembl Medaka
Match: ENSORLT00000033960.1 (pep primary_assembly:ASM223467v1:6:2318704:2335450:-1 gene:ENSORLG00000023432.1 transcript:ENSORLT00000033960.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 120.168 bits (300), Expect = 1.556e-27 Identity = 87/302 (28.81%), Postives = 161/302 (53.31%), Query Frame = 2
Query: 686 HLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL 1591
++++LE + E+E++T EY MK + TD + E ++Q+ L +++ +D IM VN +VE+WK ++ +D EI ++ LR L+ + ++ +K+NV AL + V+ER+ ++K LS+Q+ +E++ LI+ LK T G Q R+++EL+ +L E E + L E ++++ L +A R YE G +GL A+AEIK C Q+++++ E E + +N+ +L EN LR KL + E++++ ++R + + +A N +L
Sbjct: 164 QMQKSLEESVKEMEKMTDEYNKMKIDVEQTDSIMDQLRQERDHAKLQVRELADKIQSMTQENDPIMAAVNAKVEEWKVLLSGKDEEILVYHQMIQDLREKLRSAQLDLDKSNVMALQQAVQERDNQIKMLSEQVEQYTGEMEKHAQLIQQLK-----TSTSKGGTQQRKMEELKSLLRAAESRAAEAEQALKLAEAHAEEKDRALIEASNRLTQYESGTYGLEAAIAEIKECNNQIRLRDCEAEAMTKEINQLGLRINDLMDENEGLREKLGLDPREEVNLTEFKRARDLRQRQYKAENQIL 460
BLAST of NPHP6 vs. Ensembl Medaka
Match: ENSORLT00000043328.1 (pep primary_assembly:ASM223467v1:6:2309345:2331722:-1 gene:ENSORLG00000023432.1 transcript:ENSORLT00000043328.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 110.153 bits (274), Expect = 9.067e-24 Identity = 96/365 (26.30%), Postives = 181/365 (49.59%), Query Frame = 2
Query: 500 NAKLSDNVEFLRQRTNQ-LXXXXXXXXXXXXXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVL 1591
N +L +V+F R+ +Q + D + +L +L Q DL +++ L + + ++++LE + E+E++T EY MK + TD + E ++Q+ L +++ +D IM VN +VE+WK ++ +D EI ++ LR L+ + ++ +K+NV AL + V+ER+ ++K LS+Q+ +E++ LI+ LK + G S +R D E + L E ++++ L +A R YE G +GL A+AEIK C Q+++++ E E + +N+ +L EN LR KL + E++++ ++R + + +A N +L
Sbjct: 109 NEQLQQDVDFYRRELDQRVLLPSRDEADETQRKLNLANRQLYQCLEDLQRTEDENAHLKTQNEQMQKSLEESVKEMEKMTDEYNKMKIDVEQTDSIMDQLRQERDHAKLQVRELADKIQSMTQENDPIMAAVNAKVEEWKVLLSGKDEEILVYHQMIQDLREKLRSAQLDLDKSNVMALQQAVQERDNQIKMLSEQVEQYTGEMEKHAQLIQQLKTSTSKGGRSSCPTTYQR---WFITCDRWSLQTAEAEQALKLAEAHAEEKDRALIEASNRLTQYESGTYGLEAAIAEIKECNNQIRLRDCEAEAMTKEINQLGLRINDLMDENEGLREKLGLDPREEVNLTEFKRARDLRQRQYKAENQIL 470 HSP 2 Score: 57.7658 bits (138), Expect = 1.665e-7 Identity = 26/64 (40.62%), Postives = 44/64 (68.75%), Query Frame = 2
Query: 2279 IGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQY 2470
+ LPE LS S+++ I++LN++ + +LQE KE+ K L+ Y+ KFA + H+QGLLY+++
Sbjct: 602 LTLPEGLSPSSTEVISSLNEYAVRLLQELGNKEELNKKLTGTLEEYKEKFAVVSHQQGLLYKEH 665
BLAST of NPHP6 vs. Ensembl Medaka
Match: ENSORLT00000041224.1 (pep primary_assembly:ASM223467v1:4:31791053:31792326:-1 gene:ENSORLG00000022320.1 transcript:ENSORLT00000041224.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 80.1073 bits (196), Expect = 1.802e-16 Identity = 45/150 (30.00%), Postives = 90/150 (60.00%), Query Frame = 2
Query: 2828 LNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNT 3277
+ LQK LD+SVP ++ + ++ E+T KYR+ L++ + LI R ++ ++SE ++ A+ K LE K++ + LE E++ A + + K +++ ++S ++++ TLEMK++NE++RA+HA +MYE+++N+
Sbjct: 1 MTALQKALDDSVPLSELERANRQYTELTIKYRDVLQRDSCLIQRSTNLQHLQSENDSLQEQISAMIKELEITKEKLNTLEQAWEKVNTVGAE---------TGLDKEGKATINNEMVSAARRITTLEMKELNERQRAEHAHKMYEHVRNS 141
BLAST of NPHP6 vs. Ensembl Medaka
Match: ENSORLT00000027967.1 (pep primary_assembly:ASM223467v1:6:2304565:2305828:-1 gene:ENSORLG00000028369.1 transcript:ENSORLT00000027967.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 70.0922 bits (170), Expect = 4.681e-13 Identity = 40/145 (27.59%), Postives = 86/145 (59.31%), Query Frame = 2
Query: 2843 KELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNT 3277
++L + VP ++ + ++ E+T KYR+ L++ + LI R ++ ++SE ++ A+ K LE K++ + LE E++ A + + K +++ ++S ++++ TLEMK++NE++RA+HA +MYE+++N+
Sbjct: 3 RKLHKCVPLSELERANRQYTELTIKYRDVLQRDSCLIQRSTNLQHLQSENDSLQEQISAMIKELEITKEKLNTLEQAWEKVNTVGAE---------TGLDKEGKATINNEMVSAARRITTLEMKELNERQRAEHAHKMYEHVRNS 138
BLAST of NPHP6 vs. Planmine SMEST
Match: SMESG000072747.1 (SMESG000072747.1) HSP 1 Score: 4352.74 bits (11288), Expect = 0.000e+0 Identity = 2359/2372 (99.45%), Postives = 2365/2372 (99.70%), Query Frame = 2
Query: 26 MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDXXXXXXXXXXXXXXNAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLXXXXXXXXXXXXXELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDRNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQXXXXXXXXXXXXXXXXVRMLARQAGLRAGSAGMEAGDVMDAYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQTENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDXXXXXXXXXXXXXXXXXIGFXXXXXXXXXXXXXXXVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWXXXXXXXXXXXXXXXXXXXXXXXXQKIERELRDELIDSVSKEINDAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXTMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQVANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTLPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVVSNQKHGEEIKXXXXXXXXXXXXGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLXXXXXXXXXXXXDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNVEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTITDQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPAKSANSKQDSQEKVNNWEEGKRNQRXXXXXXXXXXXXXNDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADXXXXXXXXXXQVGHKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAISESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLLYNKATERVSFLEKQLQSFSEQFGVAIDLGY 7141
MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDIKKLKIIKEELEKENAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLKNQKDQNQDSNKSELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMND+NDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQKEIEKLEDERLLLKKKVRMLARQAGLRAGSAGMEAGDVMD YKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQ ENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDNLEGRNEELRNELRNSRIGFQQLQLDHDKLKQRLKVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWNEAEKRNKELEEKLTELTNHNLELQKIERELRDELIDSVSKEINDAEKRRVLELEKRELEGKHEIEKLKEIAEIATMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQ ANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGT+PDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLV SNQKHGEEIKLLRERLSAEAAAGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLKETEIK ENEIIDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPN+EMKNAMVKLTEQLRDKEKQLQILKANLADVKKTI DQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNP+KSANSKQDSQEKVNNWEEGKRNQRLQDKLKEKLQDKENDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADLKLELAALKEQVG+KLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAI+ESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKL YNKATERVSFLEKQLQSFSEQFGVAIDLGY
Sbjct: 1 MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAFNIAQFIMSYKAEENKGLNEDLEEANVDIKKLKIIKEELEKENAALQRSDGTDINVVREKRNWEMEKESMNQEIRELKSKYNSLTEDNDKKEETINKQQKEIEGLKDSNAKLSDNVEFLRQRTNQLKNQKDQNQDSNKSELAYTRSELRQKKIDLDNAQEKILELHQEMDHLKENLEMATDEIERITSEYKNMKSNFGMTDGDLQSREAECRMLRMQIEHLQEQMNDKNDADDKIMIHVNEQVEKWKQIMEERDSEICRLYEENAKLRYDLQKSGINSEKANVQALIKLVKEREQEVKDLSQQLLDAAHTIEENGDLIENLKKDLERTGGGSSGHQMRRIKELRQMLDDKEKMLRETVERLNKVENQMADREQELTDALERNKMYERGEFGLAEAVAEIKACKAQLQVKEREKEQYLQNVNKANYAAEELKFENGHLRAKLNIPIDEQLDVEGYRRQKAAEDEEERAINIVLQKEIEKLEDERLLLKKKVRMLARQAGLRAGSAGMEAGDVMDEYKALELESSMQNIEYDPVMQSMARKYESAPQGNNTWRIKEREMSSELSNAVKERAVKEDEIAKLMTRNRQLQAENDAMCDALRQIKEELVTRNWSAGAGVPVLECPVLDKLLVAMETRKLLGEFDTGIYLKTRIDNLEGRNEELRNELRNSRIGFQQLQLDHDKLKQRLKVMDPMVMMENGWNLEERIGLPENLSASASQTIAALNQHLIIVLQEKSLKEQALDKADRALDNYRRKFAFLRHRQGLLYRQYGDEKQRYEQEIEALQTRLKDIEGIRSEDNARIAEFDRMLDTLNQDDSELKRRLADLCRQITVLKVNETALTRRYSAMQEMEQTMRRENNKLKSEMIQIEAVVTDRMGYYRRFKETANYKLNVLQKELDESVPRKDMTKLQTKFDEVTEKYRNFLEKQNILIGRGESIIQIESELSKMKMDHEALKKILEAEKQRRHVLEATLEELGEAPASEQSIKSTSNSPRKTKSKLAVDSHLISMSKKMATLEMKQINEQERADHAVRMYENIKNTWNEAEKRNKELEEKLTELTNHNLELQKIERELRDELIDSVSKEINDAEKRRVLELEKRELEGKHEIEKLKEIAEIATMQTNALQQQQLSREKETGSLRQQLADIQCQSDEKSLIGKLHRHIVLLQMSETSALRKLDDLHRVQKRLEAQLLRTEQNCDEKDQNLYQTRLDGRTRVKHLRETINSLRSQFSGSIPLSRHERFTSTLIRLTEDKVKLDQELQLTLRAKFDLETEFQAANIARQTETELKDAMATKRNEKSVLESWSSKMEGLRLESLKHKRQCDLLRHEVEHLESVIKCQESQLAQVDEDIARITRDHDDKQLLWEQRENELERTIVNLENIQGEVIIAANSFQQATGTQKEQYLGTMPDPSAPLPNQLDQAMATIKKHIRVIFDKENENKALRKHGKEHENKIRELEGTLLKRERYINELRLRLPASEDRPQQMGQISDAAVTSLLNAEKSNYVDEKTMWAAQTTLSGLQERLRAKDESLMRYEQLLKEAREDLVASNQKHGEEIKLLRERLSAEAAAGTRRAGYNGQLPMATTAVATSDQYRENNELRDLLAIQTRTNEDLKLQLADIQHQLSIQKQKMETTDKINQSRLKETEIKAENEIIDLKENMNNLKRKLNEKESQIEFQNQEISRLKGDVTRSPNIEMKNAMVKLTEQLRDKEKQLQILKANLADVKKTIADQSIDALRMTKNEMANQDNIQKVLDKHTRDLSNELEANRDQILQYQRELRSARADKERVQIELDGLKADSDHKEFTAKKLKTDKSKLEQENDELRNQLQRIKNLRNLSSNDAMKQELDAMKIKLRLIEEENNQLKRNPSKSANSKQDSQEKVNNWEEGKRNQRLQDKLKEKLQDKENDIANLSKQLDTTTKALDRMRREKQAVENRLTDKWGPGALLDIDEDIERISAQPRKPMAFATPSNRSDTVDDLRRRNGELEKEIDRLMRNADSSDSKTVNNVALKEAEMRNRILQRNIEDLERRLTQSGSTSVITLEKEKAMQKEIMRLNGDNLELKFEAEAARKEIPRLKEKVTDQKKFIDLLKSEKEALEGKSNRSLESSASTMSNIKRVGDSGKSTKELEKMIGRMKKVVEKTQRENERLKEAPGVIMNEQVQLLRTENADLKLELAALKEQVGNKLAERYDAKERGMARVVSDYEKLRKDLGREAEEHEKTRIDLKQMARDVDKLEKQNADLESKLAIAESRGRQNVSRIANKELQDENRKLSSIIANLQSQLKDKHNQNPDSSKVEELKLRYNKATERVSFLEKQLQSFSEQFGVAIDLGY 2372 The following BLAST results are available for this feature:
BLAST of NPHP6 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of NPHP6 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of NPHP6 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of NPHP6 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 2
BLAST of NPHP6 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of NPHP6 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 3
BLAST of NPHP6 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 4
BLAST of NPHP6 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of NPHP6 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of NPHP6 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of NPHP6 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of NPHP6 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of NPHP6 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 4
BLAST of NPHP6 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Cross References
External references for this transcript
Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019531 ID=SMED30019531|Name=NPHP6|organism=Schmidtea mediterranea sexual|type=transcript|length=7356bpback to top protein sequence of SMED30019531-orf-1 >SMED30019531-orf-1 ID=SMED30019531-orf-1|Name=SMED30019531-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=2373bp MSSSDWDRILKVKTDQLNSMSPDDIDIIYELMVNIDDISNVDDADKLYKAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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