SH3 domain-containing protein

Overview
NameSH3 domain-containing protein
Smed IDSMED30019497
Length (bp)2118
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SH3 domain-containing protein (SMED30019497) t-SNE clustered cells

Violin plots show distribution of expression levels for SH3 domain-containing protein (SMED30019497) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SH3 domain-containing protein (SMED30019497) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SH3 domain-containing protein (SMED30019497) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30019497

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 9

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
head regionSMED30019497h1SMcG0018035 SmedASXL_010886SmedAsxl_ww_GCZZ01PMID:27034770
Currie et al., 2016		whole organism asexual adult RNA-sequencing evidence
nervous systemSMED30019497h1SMcG0018035 dd_Smed_v4_11051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30019497h1SMcG0018035 dd_Smed_v4_11051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neuronSMED30019497h1SMcG0018035 dd_Smed_v4_11051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		whole organism asexual adult colorimetric in situ hybridization evidence
non-ciliated neuronSMED30019497h1SMcG0018035 dd_Smed_v4_11051_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30019497h1SMcG0018035 dd_Smed_v6_11051_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
head regionSMED30019497h1SMcG0018035 OX_Smed_1.0.23363ox_Smed_v2PMID:24238224
Kao et al., 2013		whole organism asexual adult RNA-sequencing evidence
neuronSMED30019497h1SMcG0018035 dd_Smed_v6_11051_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cholinergic neuronSMED30019497h1SMcG0018035 dd_Smed_v6_11051_0dd_Smed_v6PMID:29674432
Plass et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Human
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:HGNC Symbol;Acc:HGNC:23990])

HSP 1 Score: 72.4034 bits (176), Expect = 8.332e-13
Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDG 1834
            SYV LY F  + +++L L+ G ++ +++ S+ DWW G+   R+G+FPA +VQ++  G +VW+  +  S N + G
Sbjct:  296 SYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQG 369
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Human
Match: STAC (SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:HGNC:11353])

HSP 1 Score: 69.707 bits (169), Expect = 3.891e-12
Identity = 25/69 (36.23%), Postives = 44/69 (63.77%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVR 1807
            L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   RIG+FPA +VQ++     +++ VR
Sbjct:  224 LQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVR 292
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Human
Match: STAC (SH3 and cysteine rich domain [Source:HGNC Symbol;Acc:HGNC:11353])

HSP 1 Score: 69.707 bits (169), Expect = 6.602e-12
Identity = 25/69 (36.23%), Postives = 44/69 (63.77%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVR 1807
            L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   RIG+FPA +VQ++     +++ VR
Sbjct:  285 LQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVR 353
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Human
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:HGNC Symbol;Acc:HGNC:28423])

HSP 1 Score: 60.4622 bits (145), Expect = 7.076e-10
Identity = 23/74 (31.08%), Postives = 41/74 (55.41%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
            +V LY F A   D+LD   G K+ V++ S+ +WW G+   ++G+FP  ++ ++  G  V ++ R    N + G 
Sbjct:   66 FVALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFIIRVRAGERVHRVTRSFVGNREIGQ 139
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Human
Match: ITSN2 (intersectin 2 [Source:HGNC Symbol;Acc:HGNC:6184])

HSP 1 Score: 58.151 bits (139), Expect = 1.037e-9
Identity = 23/50 (46.00%), Postives = 30/50 (60.00%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            + +YD+ A   DEL    G  +NV+N  DPDWW G  NG  G FP+ YV+
Sbjct:   61 IAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 110
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 58.9214 bits (141), Expect = 9.604e-9
Identity = 26/51 (50.98%), Postives = 33/51 (64.71%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            Y V+YDF A  + +L L  G  + VL  +D +WW GRCNGR G FPA YV+
Sbjct:  627 YTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 676
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 58.9214 bits (141), Expect = 9.696e-9
Identity = 26/51 (50.98%), Postives = 33/51 (64.71%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            Y V+YDF A  + +L L  G  + VL  +D +WW GRCNGR G FPA YV+
Sbjct:  629 YTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 678
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 58.9214 bits (141), Expect = 1.289e-8
Identity = 26/51 (50.98%), Postives = 33/51 (64.71%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            Y V+YDF A  + +L L  G  + VL  +D +WW GRCNGR G FPA YV+
Sbjct:  889 YTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 938
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 58.9214 bits (141), Expect = 1.300e-8
Identity = 26/51 (50.98%), Postives = 33/51 (64.71%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            Y V+YDF A  + +L L  G  + VL  +D +WW GRCNGR G FPA YV+
Sbjct:  887 YTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 936
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Match: itsn-1 (ITSN (Intersectin) family [Source:UniProtKB/TrEMBL;Acc:E6N0W1])

HSP 1 Score: 58.151 bits (139), Expect = 1.715e-8
Identity = 26/51 (50.98%), Postives = 33/51 (64.71%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            Y V+YDF A  + +L L  G  + VL  +D +WW GRCNGR G FPA YV+
Sbjct:  434 YTVIYDFEAVETTDLALHVGDTILVLEKND-EWWKGRCNGREGIFPANYVE 483
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0330010)

HSP 1 Score: 96.6709 bits (239), Expect = 1.356e-20
Identity = 39/97 (40.21%), Postives = 65/97 (67.01%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDD-GNTFKLRKGELF 1867
            +P  H+ L TN YV++Y+F AR +DELDLKAG+KV V+++SDPDWW G+  GR+GYFP+ Y  +++      ++  ++ ++D + G    L + ++ 
Sbjct:  419 SPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV 515
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0475072)

HSP 1 Score: 97.0561 bits (240), Expect = 2.860e-20
Identity = 39/97 (40.21%), Postives = 65/97 (67.01%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDD-GNTFKLRKGELF 1867
            +P  H+ L TN YV++Y+F AR +DELDLKAG+KV V+++SDPDWW G+  GR+GYFP+ Y  +++      ++  ++ ++D + G    L + ++ 
Sbjct: 1241 SPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV 1337
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0330011)

HSP 1 Score: 95.9005 bits (237), Expect = 5.438e-20
Identity = 66/220 (30.00%), Postives = 104/220 (47.27%), Query Frame = 2 
Query: 1262 RTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTS-----------------SPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDD-GNTFKLRKGELF 1867
            R  + N +MKS S+D P+          +  L G  + TS                 +P    S  + S  SP H  R     L  A R  R    + +  E   +   A  +PC        +P  H+ L TN YV++Y+F AR +DELDLKAG+KV V+++SDPDWW G+  GR+GYFP+ Y  +++      ++  ++ ++D + G    L + ++ 
Sbjct:  929 RRQKLNLRMKSLSLDSPESSELHGQFRRRTQLPGTGASTSAGSGYYHGGSGGHLEHSTPPSNNSRLH-SPSSPSHPGR----KLLYATRGMRGGSVD-LPDEMEKSQSSASTSPCL-------SPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV 1135
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0330012)

HSP 1 Score: 95.9005 bits (237), Expect = 6.885e-20
Identity = 39/97 (40.21%), Postives = 65/97 (67.01%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDD-GNTFKLRKGELF 1867
            +P  H+ L TN YV++Y+F AR +DELDLKAG+KV V+++SDPDWW G+  GR+GYFP+ Y  +++      ++  ++ ++D + G    L + ++ 
Sbjct: 1039 SPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV 1135
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Fly
Match: Stacl (gene:FBgn0263980 transcript:FBtr0344201)

HSP 1 Score: 95.5153 bits (236), Expect = 7.194e-20
Identity = 39/97 (40.21%), Postives = 65/97 (67.01%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDD-GNTFKLRKGELF 1867
            +P  H+ L TN YV++Y+F AR +DELDLKAG+KV V+++SDPDWW G+  GR+GYFP+ Y  +++      ++  ++ ++D + G    L + ++ 
Sbjct: 1029 SPKTHRLLPTNLYVIIYNFKARHADELDLKAGYKVTVIDNSDPDWWKGKVLGRVGYFPSKYCVRLNANEKPLQVTHNLQVSDSERGENLTLLRDQIV 1125
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 63.5438 bits (153), Expect = 2.291e-10
Identity = 32/97 (32.99%), Postives = 51/97 (52.58%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN-TFK-----LRKGELFNKAHKIA 1888
            Y+ LY F A   D+LD   G ++ VL+ S+ +WW G+   + GY P  Y+ ++  G  V+K+ R    N + G  T K     ++KGE  N   K++
Sbjct:  220 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSFVGNREMGQITLKKDQIVVKKGEEVNGYLKVS 316
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 63.5438 bits (153), Expect = 2.659e-10
Identity = 32/97 (32.99%), Postives = 51/97 (52.58%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN-TFK-----LRKGELFNKAHKIA 1888
            Y+ LY F A   D+LD   G ++ VL+ S+ +WW G+   + GY P  Y+ ++  G  V+K+ R    N + G  T K     ++KGE  N   K++
Sbjct:  222 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSFVGNREMGQITLKKDQIVVKKGEEVNGYLKVS 318
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 63.5438 bits (153), Expect = 2.659e-10
Identity = 32/97 (32.99%), Postives = 51/97 (52.58%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN-TFK-----LRKGELFNKAHKIA 1888
            Y+ LY F A   D+LD   G ++ VL+ S+ +WW G+   + GY P  Y+ ++  G  V+K+ R    N + G  T K     ++KGE  N   K++
Sbjct:  222 YMALYRFKAIEKDDLDFHPGDRITVLDDSNEEWWRGKIGEKTGYLPMTYIIRVRAGERVYKVTRSFVGNREMGQITLKKDQIVVKKGEEVNGYLKVS 318
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Match: stac (SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-GENE-131121-459])

HSP 1 Score: 61.2326 bits (147), Expect = 1.613e-9
Identity = 26/88 (29.55%), Postives = 51/88 (57.95%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            L  N+YV L+ F A+ + +L+++ G ++ + + S+ DWW G    RIG+FPAA+  ++   + V++  R      + G    L++G++
Sbjct:  258 LLLNTYVALFGFTAQDNQDLEMRPGDRIVLADDSNDDWWKGVIEDRIGFFPAAFAHQVTSSDRVFRCNRTFIGCKEQGQ-ITLKEGQI 344
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Match: stac (SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-GENE-131121-459])

HSP 1 Score: 60.077 bits (144), Expect = 3.874e-9
Identity = 26/88 (29.55%), Postives = 51/88 (57.95%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            L  N+YV L+ F A+ + +L+++ G ++ + + S+ DWW G    RIG+FPAA+  ++   + V++  R      + G    L++G++
Sbjct:  262 LLLNTYVALFGFTAQDNQDLEMRPGDRIVLADDSNDDWWKGVIEDRIGFFPAAFAHQVTSSDRVFRCNRTFIGCKEQGQ-ITLKEGQI 348
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:NCBI gene;Acc:100491407])

HSP 1 Score: 75.8702 bits (185), Expect = 5.594e-14
Identity = 31/84 (36.90%), Postives = 50/84 (59.52%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
             YV LY F  +  ++L L+ G +V VL+ S+ DWW G+C  R G+FPA +VQ++  G +VWK  +      + G    L++G++
Sbjct:  291 CYVALYKFLPQEINDLPLQPGDRVMVLDDSNEDWWKGKCGDRTGFFPANFVQRVRLGETVWKSTKAFQGIKEQGQ-LCLKEGQV 373
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:493233])

HSP 1 Score: 65.0846 bits (157), Expect = 1.157e-10
Identity = 25/80 (31.25%), Postives = 46/80 (57.50%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNT 1840
            + ++ +V LY F A   D+LD +AG ++ V++ S+ +WW G+   + GYFPA ++ ++     V+K+ R    N + G  
Sbjct:  229 MQSHYFVALYRFKALEKDDLDFQAGERITVIDDSNEEWWRGKVGEKAGYFPANFIIRVRAAERVYKVTRSFVGNREIGQI 308
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:493233])

HSP 1 Score: 65.0846 bits (157), Expect = 1.376e-10
Identity = 27/88 (30.68%), Postives = 51/88 (57.95%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            + ++ +V LY F A   D+LD +AG ++ V++ S+ +WW G+   + GYFPA ++ ++     V+K+ R    N + G    L+K ++
Sbjct:  224 MQSHYFVALYRFKALEKDDLDFQAGERITVIDDSNEEWWRGKVGEKAGYFPANFIIRVRAAERVYKVTRSFVGNREIGQI-TLKKDQI 310
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Match: PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1 [Source:NCBI gene;Acc:100379705])

HSP 1 Score: 61.6178 bits (148), Expect = 2.092e-9
Identity = 27/53 (50.94%), Postives = 34/53 (64.15%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            Y VLYD+ A+ SDELD+ AG  V VL   D  WWT   NG+IG  P +Y+ K+
Sbjct:  334 YSVLYDYSAQNSDELDITAGDVVRVLEEGDDGWWTVERNGKIGLVPGSYLGKL 386
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Match: PSTPIP1 (proline-serine-threonine phosphatase interacting protein 1 [Source:NCBI gene;Acc:100379705])

HSP 1 Score: 61.6178 bits (148), Expect = 2.320e-9
Identity = 27/53 (50.94%), Postives = 34/53 (64.15%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            Y VLYD+ A+ SDELD+ AG  V VL   D  WWT   NG+IG  P +Y+ K+
Sbjct:  359 YSVLYDYSAQNSDELDITAGDVVRVLEEGDDGWWTVERNGKIGLVPGSYLGKL 411
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Match: Stac2 (SH3 and cysteine rich domain 2 [Source:MGI Symbol;Acc:MGI:2144518])

HSP 1 Score: 72.7886 bits (177), Expect = 4.310e-13
Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDG 1834
            SYV LY F  + +++L L+ G ++ +++ S+ DWW G+   R+G+FPA +VQ++  G +VW+  +  S N + G
Sbjct:  293 SYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQG 366
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Match: Stac (src homology three (SH3) and cysteine rich domain [Source:MGI Symbol;Acc:MGI:1201400])

HSP 1 Score: 70.8626 bits (172), Expect = 1.872e-12
Identity = 27/87 (31.03%), Postives = 48/87 (55.17%), Query Frame = 2 
Query: 1577 NNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
              P+    L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   R+G+FPA +VQ++     +++ VR      D G 
Sbjct:  278 QGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQ 364
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Match: Grap2 (GRB2-related adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1333842])

HSP 1 Score: 61.6178 bits (148), Expect = 1.075e-9
Identity = 26/48 (54.17%), Postives = 33/48 (68.75%), Query Frame = 2 
Query: 1622 VLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYV 1765
             LYDF A   DEL  ++G  V VL+SS+P WWTGR + ++G FPA YV
Sbjct:  270 ALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 317
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Match: Grap2 (GRB2-related adaptor protein 2 [Source:MGI Symbol;Acc:MGI:1333842])

HSP 1 Score: 61.6178 bits (148), Expect = 1.075e-9
Identity = 26/48 (54.17%), Postives = 33/48 (68.75%), Query Frame = 2 
Query: 1622 VLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYV 1765
             LYDF A   DEL  ++G  V VL+SS+P WWTGR + ++G FPA YV
Sbjct:  270 ALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 317
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Match: Itsn2 (intersectin 2 [Source:MGI Symbol;Acc:MGI:1338049])

HSP 1 Score: 62.7734 bits (151), Expect = 1.323e-9
Identity = 23/50 (46.00%), Postives = 31/50 (62.00%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            + +YD+ A   DEL+   G  +NV+N  DPDWW G  NG  G FP+ YV+
Sbjct:  653 IAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETNGLTGLFPSNYVK 702
[Close]
BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Match: sp|A0JNJ1|STAC_BOVIN (SH3 and cysteine-rich domain-containing protein OS=Bos taurus OX=9913 GN=STAC PE=2 SV=1)

HSP 1 Score: 75.485 bits (184), Expect = 4.262e-13
Identity = 29/87 (33.33%), Postives = 50/87 (57.47%), Query Frame = 2 
Query: 1577 NNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
              P+    L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   RIG+FPA +VQ++H    +++ VR  S   + G 
Sbjct:  278 QGPLSKDPLQMNTYVALYKFVPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRIGFFPANFVQRVHQNEKIFRCVRTFSGCKEQGQ 364
[Close]
BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q8R1B0|STAC2_MOUSE (SH3 and cysteine-rich domain-containing protein 2 OS=Mus musculus OX=10090 GN=Stac2 PE=1 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 3.015e-12
Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDG 1834
            SYV LY F  + +++L L+ G ++ +++ S+ DWW G+   R+G+FPA +VQ++  G +VW+  +  S N + G
Sbjct:  293 SYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQG 366
[Close]
BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q6ZMT1|STAC2_HUMAN (SH3 and cysteine-rich domain-containing protein 2 OS=Homo sapiens OX=9606 GN=STAC2 PE=1 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 4.001e-12
Identity = 27/74 (36.49%), Postives = 48/74 (64.86%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDG 1834
            SYV LY F  + +++L L+ G ++ +++ S+ DWW G+   R+G+FPA +VQ++  G +VW+  +  S N + G
Sbjct:  296 SYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQG 369
[Close]
BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Match: sp|P97306|STAC_MOUSE (SH3 and cysteine-rich domain-containing protein OS=Mus musculus OX=10090 GN=Stac PE=1 SV=1)

HSP 1 Score: 70.8626 bits (172), Expect = 1.310e-11
Identity = 27/87 (31.03%), Postives = 48/87 (55.17%), Query Frame = 2 
Query: 1577 NNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
              P+    L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   R+G+FPA +VQ++     +++ VR      D G 
Sbjct:  278 QGPLSKDPLQMNTYVALYRFIPQENEDLEMRPGDMITLLEDSNEDWWKGKIQDRVGFFPANFVQRVEEHEKIYRCVRTFIGCKDQGQ 364
[Close]
BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Match: sp|Q99469|STAC_HUMAN (SH3 and cysteine-rich domain-containing protein OS=Homo sapiens OX=9606 GN=STAC PE=1 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 3.170e-11
Identity = 25/69 (36.23%), Postives = 44/69 (63.77%), Query Frame = 2 
Query: 1601 LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVR 1807
            L  N+YV LY F  + +++L+++ G  + +L  S+ DWW G+   RIG+FPA +VQ++     +++ VR
Sbjct:  285 LQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVR 353
[Close]
BLAST of SH3 domain-containing protein vs. TrEMBL
Match: A0A267G8I5 (SH3 domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000590g3 PE=4 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 4.467e-29
Identity = 117/388 (30.15%), Postives = 188/388 (48.45%), Query Frame = 2 
Query:  776 SSNNLAINYPDQKLSPNEELRKI---PDSLSGKSVPRRRLDARMKSLSVDNPEVEIHEENEDIDD-------SIYHQ----SRQFSNSFTNTNAIESKTLANPYSMRRKYLK-EQHRSISMENEH-------HAIVT--SSCENYRXXXXXXXXXXXXPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            SSN  A+  P++ +      R I   P     K+ P   LD+R KS+S D+P+                   S+ H+    +++ S+SFTNTN IES+   NP+  RRK ++  +++S+S++ ++       H  ++  S C   R  S   SS   + R+S R      ++S+   Q +    N R  R  WKMKSFS+D PD   +++ ++    L+G   H S+           +D    D  +S      +               S I + + +       P  +   +   RLS N +VVLYDF AR  DE+DL+AG+K++    +DPDWW GRC GR G FP+AYVQ++  G+ +W+++R  +L  D G + KL +G++ 
Sbjct:  119 SSNTAALEQPEKLVEFAGGGRTITTQPPKSGTKARPM--LDSRKKSVSADSPDKAACGGGSGGGADGGGRWTSVPHRLEDDTKKKSSSFTNTNFIESQAPPNPH--RRKQMQFGRNKSLSVDQDNTGSARLRHVELSDESICPRERLGSEASSSRQSASRESPR--RHFGEDSQLRGQDASRPQNKR--RLQWKMKSFSLDSPDVKENLTGTAGSN-LQGTQQHPST----------GTDETAADELNSLGATGVSV--------------STIETTKVKQ------PHRNRKMLRDSRLSGNLFVVLYDFKARHRDEMDLRAGFKLSCSEMADPDWWLGRCMGRAGLFPSAYVQRVREGDVIWRVLRPQTLVTDCGGSVKLYRGQIV 467
[Close]
BLAST of SH3 domain-containing protein vs. TrEMBL
Match: A0A267G8I3 (SH3 domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000590g2 PE=4 SV=1)

HSP 1 Score: 132.88 bits (333), Expect = 2.707e-28
Identity = 118/388 (30.41%), Postives = 189/388 (48.71%), Query Frame = 2 
Query:  776 SSNNLAINYPDQKLSPNEELRKI---PDSLSGKSVPRRRLDARMKSLSVDNPEVEIHEENEDIDD-------SIYHQ----SRQFSNSFTNTNAIESKTLANPYSMRRKYLK-EQHRSISMENEH-------HAIVT--SSCENYRXXXXXXXXXXXXPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            SSN  A+  P++ +      R I   P     K+ P   LD+R KS+S D+P+                   S+ H+    +++ S+SFTNTN IES+   NP+  RRK L+  +++S+S++ ++       H  ++  S C   R  S   SS   + R+S R      ++S+   Q +    N R  R  WKMKSFS+D P+   +++ ++    L+G   H S+          S+D    D  +S      +               S I + + +       P  +   +   RLS N +VVLYDF AR  DE+DL+AG+K++    +DPDWW GRC GR G FP+AYVQ++  G+ +W+++R  +L  D G + KL +G++ 
Sbjct:  451 SSNTAALEQPEKLVEFAGGGRTITTQPPKSGTKARPM--LDSRKKSVSADSPDKAACGGGSGGGADGGGRWTSVPHRLEDDTKKKSSSFTNTNFIESQAPPNPH--RRKQLQFGRNKSLSVDQDNTGSARLRHVELSDESICPRQRLGSEASSSRQSASRESPR--RHFGEDSQLRGQDASRPQNKR--RLQWKMKSFSLDSPEVKENLTGTAGSN-LQGTQQHPST----------STDETAADELNSLGATGVSV--------------STIETTKVKQ------PHRNRKMLRDSRLSGNLFVVLYDFKARHRDEMDLRAGFKLSCSEMADPDWWLGRCMGRAGLFPSAYVQRVREGDVIWRVLRPQTLVTDCGGSVKLYRGQIV 799
[Close]
BLAST of SH3 domain-containing protein vs. TrEMBL
Match: A0A267GJZ9 (SH3 domain-containing protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000590g1 PE=4 SV=1)

HSP 1 Score: 125.946 bits (315), Expect = 4.737e-26
Identity = 96/311 (30.87%), Postives = 158/311 (50.80%), Query Frame = 2 
Query:  965 IYHQSRQFSNSFTNTNAIESKTLANPYSMRRKYLK-EQHRSISMENEH-------HAIVT--SSCENYRXXXXXXXXXXXXPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            +   +++ S+SFTNTN IES+   NP+  RRK ++  +++S+S++ ++       H  ++  S C   R  S   SS   + R+S R      ++S+   Q +    N R  R  WKMKSFS+D P+   +++ ++    L+G   H S+           +D    D  +S      +               S I + + +       P  +   +   RLS N +VVLYDF AR  DE+DL+AG+K++    +DPDWW GRC GR G FP+AYVQ++  G+ +W+++R  +L  D G + KL +G++ 
Sbjct:  526 LEDDTKKKSSSFTNTNFIESQAPPNPH--RRKQMQFGRNKSLSVDQDNTGSARLRHVELSDESICPRQRLGSEASSSRQSASRESPR--RHFGEDSQLRGQDASRPQNKR--RLQWKMKSFSLDSPEVKENLTGTAG-LNLQGTQQHPST----------GTDETAADELNSLGATGVSV--------------STIETTKVKQ------PHRNRKMLRDSRLSGNLFVVLYDFKARHRDEMDLRAGFKLSCSEMADPDWWLGRCMGRAGLFPSAYVQRVREGDVIWRVLRPQTLVTDCGGSVKLYRGQIV 799
[Close]
BLAST of SH3 domain-containing protein vs. TrEMBL
Match: A0A1D2MY65 (SH3 and cysteine-rich domain-containing protein 3 OS=Orchesella cincta OX=48709 GN=Ocin01_08738 PE=4 SV=1)

HSP 1 Score: 109.768 bits (273), Expect = 3.755e-24
Identity = 44/92 (47.83%), Postives = 64/92 (69.57%), Query Frame = 2 
Query: 1592 HKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            H+ L TN YVVLY+F AR  DELDLKAG+K+ V++++DPDWW G+C GR+GYFP+ YV K+H G    ++  ++ + D   N  KL + ++ 
Sbjct:   31 HRLLPTNLYVVLYNFKARHPDELDLKAGYKITVIDTTDPDWWQGKCLGRVGYFPSKYVTKLHPGEKPLQVTHNLQVTDGADNGLKLLRDQIV 122
[Close]
BLAST of SH3 domain-containing protein vs. TrEMBL
Match: J9K1K7 (SH3 domain-containing protein OS=Acyrthosiphon pisum OX=7029 PE=4 SV=1)

HSP 1 Score: 108.612 bits (270), Expect = 5.283e-23
Identity = 46/96 (47.92%), Postives = 64/96 (66.67%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            +P  H+ L  N YVVLY+F ARR DELDLKAG+KV V+++SDP WW G+C GR+GYFP  YV K+  G   W++  ++ + D D N   L + ++ 
Sbjct:   97 SPKPHRLLPNNLYVVLYNFKARREDELDLKAGYKVTVIDTSDPAWWKGKCFGRVGYFPYNYVTKVQPGERPWQVTINLQVLDVDNNPLTLLRDQIV 192
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Match: STAC2 (SH3 and cysteine rich domain 2 [Source:HGNC Symbol;Acc:HGNC:23990])

HSP 1 Score: 65.4698 bits (158), Expect = 6.440e-11
Identity = 23/67 (34.33%), Postives = 43/67 (64.18%), Query Frame = 2 
Query: 1604 STNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIV 1804
            + ++YV LY F  +  ++L+L  G +V V + S+ +WW G+   ++G+FPA +VQ++  G  VW++ 
Sbjct:  261 AIHTYVALYRFLPQEQNDLELHPGDRVQVTDDSNEEWWKGKSGDKVGFFPANFVQRVRPGERVWRVT 327
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Match: STAC3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:103033422])

HSP 1 Score: 62.7734 bits (151), Expect = 4.015e-10
Identity = 32/97 (32.99%), Postives = 53/97 (54.64%), Query Frame = 2 
Query: 1616 YVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN-TFK-----LRKGELFNKAHKIA 1888
            Y+ LY F A   D+LDL  G ++ V++ S+ +WW G+   R G+ PA Y+ ++  G  V+K+ R    N + G  T K     ++KG+  N   K++
Sbjct:  232 YLALYRFKAIEKDDLDLHPGDRITVIDDSNEEWWRGKIGERSGFLPANYIIRVRSGERVYKVTRSFVGNREMGQITLKKDQIVVKKGDEVNGYLKVS 328
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Match: grap2a (GRB2-related adapter protein-like [Source:NCBI gene;Acc:103029038])

HSP 1 Score: 58.151 bits (139), Expect = 4.724e-9
Identity = 29/65 (44.62%), Postives = 33/65 (50.77%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
             P  H R ST     +YDF A   DEL   AG  + V++ SD  WW GR  GR G FPA Y   I
Sbjct:  165 TPYLHPR-STLQVKAMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 228
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Match: grap2a (GRB2-related adapter protein-like [Source:NCBI gene;Acc:103029038])

HSP 1 Score: 58.151 bits (139), Expect = 8.269e-9
Identity = 32/92 (34.78%), Postives = 40/92 (43.48%), Query Frame = 2 
Query: 1523 IASHQARHNPCRYDPEFDNNPVDHKRLS--------TNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            +   Q R++P         NP   +R S        T     +YDF A   DEL   AG  + V++ SD  WW GR  GR G FPA Y   I
Sbjct:  203 LEEKQGRNSPV-------TNPTGPRRTSDTMPAPRSTLQVKAMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 287
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Match: grap2a (GRB2-related adapter protein-like [Source:NCBI gene;Acc:103029038])

HSP 1 Score: 58.151 bits (139), Expect = 8.269e-9
Identity = 32/92 (34.78%), Postives = 40/92 (43.48%), Query Frame = 2 
Query: 1523 IASHQARHNPCRYDPEFDNNPVDHKRLS--------TNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            +   Q R++P         NP   +R S        T     +YDF A   DEL   AG  + V++ SD  WW GR  GR G FPA Y   I
Sbjct:  203 LEEKQGRNSPV-------TNPTGPRRTSDTMPAPRSTLQVKAMYDFIAEEEDELGFNAGDIIEVIDRSDASWWKGRLQGRTGLFPANYTAPI 287
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009546.1 (pep scaffold:Pmarinus_7.0:GL485512:1487:9666:1 gene:ENSPMAG00000008635.1 transcript:ENSPMAT00000009546.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.5438 bits (153), Expect = 2.367e-12
Identity = 29/84 (34.52%), Postives = 50/84 (59.52%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            +YVVLY F A+  D+L L  G ++ V++ S+ +WW G+   ++GYFPA +V ++  G  V ++ R    N   G    L++G++
Sbjct:   18 TYVVLYKFVAQEKDDLQLTPGQRLIVIDDSNEEWWKGKMGDKLGYFPANFVIRVRAGERVLRLSRTFVGNKQLGQI-TLKQGQV 100
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Match: stac3 (SH3 and cysteine rich domain 3 [Source:NCBI gene;Acc:445111])

HSP 1 Score: 62.3882 bits (150), Expect = 7.874e-11
Identity = 25/75 (33.33%), Postives = 45/75 (60.00%), Query Frame = 2 
Query: 1613 SYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
            ++V L+ F  R  D+L L+ G ++++L+ S+ +WW G+   R+GYFPA +V ++  G  V++ +R    N   G 
Sbjct:  196 TFVALHRFGTREKDDLALEPGDRLSILDDSNEEWWKGKLGDRVGYFPANFVVRVRPGERVFQALRTFVGNKQLGQ 270
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Match: stac (SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-GENE-131121-459])

HSP 1 Score: 62.7734 bits (151), Expect = 1.045e-10
Identity = 44/156 (28.21%), Postives = 69/156 (44.23%), Query Frame = 2 
Query: 1412 KSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDN-----NPVDHKR---------LSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
            K     G      HSN   A     P   + I P    ASHQ+R  P RY   F       N +  K          L    YV L  +  + S +L ++ G  +++++ S+ +WW GR + R+G+FPA +VQ++  G  V++ VR  +   + G 
Sbjct:  182 KGRGCEGEPGPCRHSNSMDADLMDVPEEMD-IGPAGDSASHQSRQ-PARYSYPFHTKHVFCNIIKVKASLSSLRPSPLQMYQYVALSQYVPQDSGDLAIQPGDILSIVDDSNEEWWKGRIDDRVGFFPANFVQRVRPGERVFRCVRACAGTREHGQ 335
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Match: grb2a (growth factor receptor-bound protein 2a [Source:ZFIN;Acc:ZDB-GENE-041121-1])

HSP 1 Score: 53.5286 bits (127), Expect = 2.686e-8
Identity = 22/47 (46.81%), Postives = 30/47 (63.83%), Query Frame = 2 
Query: 1625 LYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYV 1765
            L+DF  +   EL  + G  + V++SSDP+WW G C+GR G FP  YV
Sbjct:  165 LFDFEPQEDGELGFRRGDFITVVDSSDPNWWKGSCHGRAGMFPRNYV 211
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Match: ABI1 (abl interactor 1 [Source:HGNC Symbol;Acc:HGNC:11320])

HSP 1 Score: 50.8322 bits (120), Expect = 6.963e-7
Identity = 25/76 (32.89%), Postives = 37/76 (48.68%), Query Frame = 2 
Query: 1562 DPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI-HYGN 1786
            DP  D +P    ++     V +YD+   + DEL    G  + V+  +D  W+ G  NG  G FP  YV+ I HY +
Sbjct:  379 DPYADGDPEWAPKIYIEKVVAVYDYVQDKDDELSFHEGSIIYVVRKNDDGWYEGATNGHTGLFPGNYVEPIMHYAD 454
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Match: PIN3 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with LSB1 cooperatively inhibits the nucleation of actin filaments; short-lived protein whose levels increase in response to thermal stress; induces the formation of the [PIN+] and [RNQ+] prions when overproduced; PIN3 has a paralog, LSB1, that arose from the whole genome duplication [Source:SGD;Acc:S000006358])

HSP 1 Score: 59.6918 bits (143), Expect = 1.309e-10
Identity = 30/78 (38.46%), Postives = 40/78 (51.28%), Query Frame = 2 
Query: 1550 PCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYG 1783
            P ++DP   N P +    S      LY F  ++  +L LK G KV +L    P+W+ G CNGR G FPA YV+    G
Sbjct:   39 PAKWDPA--NAPRNASPASLEYVEALYQFDPQQDGDLGLKPGDKVQLLEKLSPEWYKGSCNGRTGIFPANYVKPAFSG 114
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Match: LSB1 (Negative regulator of actin nucleation-promoting factor activity; interacts with Las17p, a homolog of human Wiskott-Aldrich Syndrome protein (WASP), via an N-terminal SH3 domain, and along with PIN3 cooperatively inhibits the nucleation of actin filaments; overexpression blocks receptor-mediated endocytosis; protein increases in abundance and forms nuclear foci in response to DNA replication stress; LSB1 has a paralog, PIN3, that arose from the whole genome duplication [Source:SGD;Acc:S000003368])

HSP 1 Score: 59.6918 bits (143), Expect = 2.326e-10
Identity = 29/68 (42.65%), Postives = 40/68 (58.82%), Query Frame = 2 
Query: 1568 EFDNNPVDHKRLSTNSYV-VLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            ++D N    +   T  YV  LYDF A++  +L LK G K+ VL    PDW+ G+ N +IG FPA YV+
Sbjct:   41 KWDGNQRSPQNADTEEYVEALYDFEAQQDGDLSLKTGDKIQVLEKISPDWYRGKSNNKIGIFPANYVK 108
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Match: LSB3 (Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; protein abundance increases in response to DNA replication stress; LSB3 has a paralog, YSC84, that arose from the whole genome duplication [Source:SGD;Acc:S000002968])

HSP 1 Score: 54.6842 bits (130), Expect = 2.620e-8
Identity = 25/54 (46.30%), Postives = 31/54 (57.41%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDP--DWWTGRCNGRIGYFPAAYVQKI 1774
            V LY F    S +L  + G  + +L  SD   DWWTGR NGR G FPA YV+ +
Sbjct:  406 VALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV 459
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Match: YSC84 (Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication [Source:SGD;Acc:S000001058])

HSP 1 Score: 53.5286 bits (127), Expect = 6.800e-8
Identity = 25/57 (43.86%), Postives = 34/57 (59.65%), Query Frame = 2 
Query: 1604 STNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDP--DWWTGRCNGRIGYFPAAYVQ 1768
            +T + V LY+F   +  +L  K G  + +L  SD   DWWTGR NG+ G FPA YV+
Sbjct:  410 ATPTAVALYNFAGEQPGDLAFKKGDVITILKKSDSQNDWWTGRTNGKEGIFPANYVR 466
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Match: RVS167 (Calmodulin-binding actin-associated protein; roles in endocytic membrane tabulation and constriction, and exocytosis; N-BAR domain protein that interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized growth; homolog of mammalian amphiphysin [Source:SGD;Acc:S000002796])

HSP 1 Score: 48.521 bits (114), Expect = 2.376e-6
Identity = 22/53 (41.51%), Postives = 31/53 (58.49%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPD---WWTGRCNGRIGYFPAAYVQ 1768
              LYD+ A+ + +L   AG  + ++  + PD   WWTGR NG+ G FP  YVQ
Sbjct:  427 TALYDYQAQAAGDLSFPAGAVIEIVQRT-PDVNEWWTGRYNGQQGVFPGNYVQ 478
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Match: EDO27384 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9E3])

HSP 1 Score: 50.0618 bits (118), Expect = 3.662e-8
Identity = 22/52 (42.31%), Postives = 34/52 (65.38%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            V LYD+  + + E+ +K G  + +LNS++ DWW    N R G+ PAAYV++I
Sbjct:    9 VALYDYQEKTAREVSMKKGDILTLLNSTNKDWWKVETNDRQGFVPAAYVKRI 60
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Match: EDO29864 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2F6])

HSP 1 Score: 50.447 bits (119), Expect = 1.093e-7
Identity = 24/56 (42.86%), Postives = 32/56 (57.14%), Query Frame = 2 
Query: 1604 STNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRC--NGRIGYFPAAYV 1765
            S ++ V LYDF A+ + EL+ K G  + VL+  D +WW GR    G  G FP  YV
Sbjct:   57 SQDTVVALYDFVAQEAGELNFKKGNHIEVLDKEDDNWWKGRVAETGEEGLFPRNYV 112
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Match: EDO38710 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SC74])

HSP 1 Score: 50.8322 bits (120), Expect = 3.616e-7
Identity = 20/49 (40.82%), Postives = 31/49 (63.27%), Query Frame = 2 
Query: 1622 VLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            VL+D+ A  +DEL L  G ++NV+   +  WW G  +GR G FP+ +V+
Sbjct:   84 VLFDYEAENADELSLVTGIEINVIREVEDGWWEGTVDGRKGVFPSNFVK 132
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Match: EDO41303 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4L5])

HSP 1 Score: 46.2098 bits (108), Expect = 6.561e-7
Identity = 20/50 (40.00%), Postives = 31/50 (62.00%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGR-CNGRIGYFPAAYV 1765
            +V+Y + A R+DEL +  G  + VL   + +WW G   +GR GYFP+ Y+
Sbjct:    2 LVMYPYEANRADELTITPGDVITVLYQDNENWWMGELADGRQGYFPSNYI 51
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Match: EDO29744 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2S0])

HSP 1 Score: 50.0618 bits (118), Expect = 1.336e-6
Identity = 21/55 (38.18%), Postives = 33/55 (60.00%), Query Frame = 2 
Query: 1610 NSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
            N  + ++ + A++ DEL    G   NV+ S D +WW G  NG++G FP+ YVQ +
Sbjct:  153 NQVLAMFPYTAQKGDELTFYKGSVFNVM-SKDGEWWKGELNGQVGMFPSNYVQSL 206
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Match: STAC2 (SH3 and cysteine-rich domain-containing protein 2 [Source:NCBI gene;Acc:101169458])

HSP 1 Score: 72.7886 bits (177), Expect = 5.023e-13
Identity = 28/78 (35.90%), Postives = 51/78 (65.38%), Query Frame = 2 
Query: 1604 STNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
            S ++YV LY F  +  ++L+L  G +V V++ S+ +WW G+   +IG+FP+ +VQ++  G  VW++V+  S N + G+
Sbjct:  402 SIHTYVALYKFLPQEQNDLELHPGDRVQVIDDSNEEWWKGKSGDKIGFFPSNFVQRVRPGERVWRVVQGTSGNRERGH 479
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Match: STAC2 (SH3 and cysteine-rich domain-containing protein 2 [Source:NCBI gene;Acc:101171286])

HSP 1 Score: 70.8626 bits (172), Expect = 1.630e-12
Identity = 28/78 (35.90%), Postives = 47/78 (60.26%), Query Frame = 2 
Query: 1604 STNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGN 1837
            S ++YV LY F  +  ++L+L+ G +V V + S+ DWW G+   ++G+FPA +VQ++  G  V+K+      N D G 
Sbjct:  300 SLHTYVALYKFLPQEKNDLELQPGDRVQVTDDSNEDWWKGKSGHKVGFFPANFVQRVRPGERVYKVTTAFHGNRDKGQ 377
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Match: stac (SH3 and cysteine rich domain [Source:NCBI gene;Acc:101173350])

HSP 1 Score: 67.3958 bits (163), Expect = 2.295e-11
Identity = 29/95 (30.53%), Postives = 56/95 (58.95%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            N +    L  N+YV LYD+ A+ S +L+++AG ++ +++ S+ DWW G    RIG+FP+A+  ++     V++  R   +   + +   L+KG++
Sbjct:  320 NQLQRDMLKLNTYVALYDYAAQGSHDLEMRAGDRILLVDDSNNDWWKGVIEDRIGFFPSAFAHQLRAEEQVFRCNRAF-IGCKEQSQLTLKKGQI 413
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Match: stac (SH3 and cysteine rich domain [Source:NCBI gene;Acc:101173350])

HSP 1 Score: 67.0106 bits (162), Expect = 2.498e-11
Identity = 29/95 (30.53%), Postives = 56/95 (58.95%), Query Frame = 2 
Query: 1580 NPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEL 1864
            N +    L  N+YV LYD+ A+ S +L+++AG ++ +++ S+ DWW G    RIG+FP+A+  ++     V++  R   +   + +   L+KG++
Sbjct:  309 NQLQRDMLKLNTYVALYDYAAQGSHDLEMRAGDRILLVDDSNNDWWKGVIEDRIGFFPSAFAHQLRAEEQVFRCNRAF-IGCKEQSQLTLKKGQI 402
[Close]
BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Match: grap2a (growth factor receptor-bound protein 2 [Source:NCBI gene;Acc:101165394])

HSP 1 Score: 60.8474 bits (146), Expect = 9.922e-10
Identity = 45/144 (31.25%), Postives = 65/144 (45.14%), Query Frame = 2 
Query: 1355 LKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPR--PNY---HNPISPESLIASHQARHNPC--RYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYV 1765
            LK G+S++ SP    S   K +  P   N ++ +   S +RA    PN     + +   +    H  R++P    Y P+        ++ S      LYDF A  +DEL    G  + V++ SDP WW GR  GR G FPA Y 
Sbjct:  145 LKDGSSNSRSP---ASAQVKRASLPEQRNPAAAAVASSTRRASEQTPNQLMKRSGLEERAHTIGHTGRNSPASMTYPPQ-----RAQQQASAPMVRALYDFTAEEADELGFCVGDVIEVMDRSDPSWWRGRLQGRTGLFPANYT 280
[Close]
BLAST of SH3 domain-containing protein vs. Planmine SMEST
Match: SMESG000039140.1 (SMESG000039140.1)

HSP 1 Score: 1038.48 bits (2684), Expect = 0.000e+0
Identity = 531/566 (93.82%), Postives = 538/566 (95.05%), Query Frame = 2 
Query:  287 MTKRYLRFNRNRQKSTDEDEISINIDRNIPSQESEAWATRYPTRNNIKSNSNKDIYGPVDAQELPESFRNMKRIWKKAVFSIKKETKSKPGGEFTKSEIEMPTPSGDISKSKSSPGNLDVDPIYLMLRSAAYKATDGSELGPDDDKNHQIEYERNEKDIQLRDSSNNLAINYPDQKLSPNEELRKIPDSLSGKSVPRRRLDARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIESKTLANPYSMRRKYLKEQHRSISMENEHHAIVTSSCENYRXXXXXXXXXXXXPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELFNKAHKIAKAFQFVSKESV-ICGARLTTLG---KYLMTIF 1972
            MTKRYLRFNRNRQKSTDEDEISINIDRNIPSQESEAWATRYPTRNNIKSNSNKDIYGPVDAQELPESFRNMKRIWKKAVFSIKKETKSKPGGEFTKSEIEMPTPSGDISKSKSSPGNLDVDPIYLMLRSAAYKATDGSELGPDDDKNHQIEYERNEKDIQLRDSSNNLAINYPDQKLSPNEELRKIPDSLSGKSVPRRRLDARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIES    NPYSMRRKYLKEQHRSISMENEHHAIVTSSCENYRSNSSIKSSDVISPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGE+      + +  Q    ES+ IC  R++ L     Y+  IF
Sbjct:    1 MTKRYLRFNRNRQKSTDEDEISINIDRNIPSQESEAWATRYPTRNNIKSNSNKDIYGPVDAQELPESFRNMKRIWKKAVFSIKKETKSKPGGEFTKSEIEMPTPSGDISKSKSSPGNLDVDPIYLMLRSAAYKATDGSELGPDDDKNHQIEYERNEKDIQLRDSSNNLAINYPDQKLSPNEELRKIPDSLSGKSVPRRRLDARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIES----NPYSMRRKYLKEQHRSISMENEHHAIVTSSCENYRSNSSIKSSDVISPRQSSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGEIV-----VQQGSQ--DSESIPICIKRVSYLWCPIDYVGKIF 555

HSP 2 Score: 81.6481 bits (200), Expect = 7.027e-16
Identity = 37/37 (100.00%), Postives = 37/37 (100.00%), Query Frame = 1 
Query: 1861 VVQQGSQDSESIPICIKRVSYLWCPIDYVGKIFDDYI 1971
            VVQQGSQDSESIPICIKRVSYLWCPIDYVGKIFDDYI
Sbjct:  523 VVQQGSQDSESIPICIKRVSYLWCPIDYVGKIFDDYI 559
[Close]
BLAST of SH3 domain-containing protein vs. Planmine SMEST
Match: SMESG000047737.1 (SMESG000047737.1)

HSP 1 Score: 143.28 bits (360), Expect = 1.290e-39
Identity = 110/347 (31.70%), Postives = 183/347 (52.74%), Query Frame = 2 
Query:  869 VPRRRLDARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIESKTLANPYSMRRKYLKEQHRSISMENEHHAIVTSSCENYRXXXXXXXXXXXXPRQSSR-YINVI----SDESKRNSQSSVTKSNLRTTRT-----NWKMKSFSVDVPDGDVDISASSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPRPNYHNPISPESL----IASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGNSVWKIVRDISLNDDDGNTFKLRKGELF 1867
            +  R+L+ RMKS SVDNP+   +  +     SI   +R+ S+S+TNT   +S    +P   RRK L  + +S S++ E HA          ++  +  +D    R++ R Y N I    +++S + S   ++K+   +++T     +W++KSFS+D+P+ + + S S   +     NS+  +P    +    S  SP HD++       S +++      N I   +     + +HQ  H       ++        RL  N YV LYDF+ R+ DEL+L+AGWKV+ ++ SD DWWTG+CNG+ GYFPA YVQ IH G  VW+++R++S+ D +    +L K ++ 
Sbjct:  567 IMHRKLNERMKSFSVDNPDNVSNTASSP--PSISRDNRKMSSSYTNTKLYDSNVPISP--RRRKTLYGRKKSCSLDQESHA----------TSRRVAFADESMTRKADRSYDNSIFLDHNEKSFKTSNEMISKNRRNSSQTRPFYNSWRVKSFSLDMPEKEEN-SESEINHQTFPTNSNLLTPTTVGTTGTLSY-SPKHDSKRLDRISESQEKSLSMEIDNQIEVNNKNNLKVLTHQKEHIEENLSKQYTKKL--GYRLRGNLYVALYDFWCRQKDELNLRAGWKVSAIDISDADWWTGKCNGKFGYFPANYVQAIHQGEHVWRVIREVSVVDSNQTPVRLYKNQIL 895

HSP 2 Score: 40.0466 bits (92), Expect = 1.290e-39
Identity = 18/36 (50.00%), Postives = 23/36 (63.89%), Query Frame = 1 
Query: 1861 VVQQGSQDSESIPICIKRVSYLWCPIDYVGKIFDDY 1968
            +VQ GSQD + I I  K  +  WCPID V K+ D+Y
Sbjct:  895 LVQTGSQDGDQILIRTKINTTFWCPIDCVTKVVDNY 930
[Close]
BLAST of SH3 domain-containing protein vs. Planmine SMEST
Match: SMESG000038704.1 (SMESG000038704.1)

HSP 1 Score: 52.7582 bits (125), Expect = 3.146e-7
Identity = 22/50 (44.00%), Postives = 28/50 (56.00%), Query Frame = 2 
Query: 1619 VVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQ 1768
            V L+DF     DE++  AG K+  +   D  WW G  NGR G FP+ YVQ
Sbjct:  219 VALFDFDGEEEDEINFVAGEKIVNIEKIDACWWVGELNGRRGMFPSNYVQ 268
[Close]
BLAST of SH3 domain-containing protein vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1)

HSP 1 Score: 52.7582 bits (125), Expect = 5.953e-7
Identity = 29/93 (31.18%), Postives = 42/93 (45.16%), Query Frame = 2 
Query: 1496 HNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
             NP++  +L  +   + N  +Y       P  +  L       L+DF A    EL  K G  V ++   D +W+ G  NGR GYFP  YV+ I
Sbjct:  272 ENPVNDAALSGNSLFKSNTSQY-------PTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYVEII 357
[Close]
BLAST of SH3 domain-containing protein vs. Planmine SMEST
Match: SMESG000022674.1 (SMESG000022674.1)

HSP 1 Score: 52.373 bits (124), Expect = 8.591e-7
Identity = 29/93 (31.18%), Postives = 42/93 (45.16%), Query Frame = 2 
Query: 1496 HNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDFYARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKI 1774
             NP++  +L  +   + N  +Y       P  +  L       L+DF A    EL  K G  V ++   D +W+ G  NGR GYFP  YV+ I
Sbjct:  272 ENPVNDAALSGNSLFKSNTSQY-------PTANGSLKEPCARGLFDFEAENETELCFKEGEIVKLIQQVDENWFEGEVNGRQGYFPVNYVEII 357
The following BLAST results are available for this feature:
BLAST of SH3 domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STAC28.332e-1336.49SH3 and cysteine rich domain 2 [Source:HGNC Symbol... [more]
STAC3.891e-1236.23SH3 and cysteine rich domain [Source:HGNC Symbol;A... [more]
STAC6.602e-1236.23SH3 and cysteine rich domain [Source:HGNC Symbol;A... [more]
STAC37.076e-1031.08SH3 and cysteine rich domain 3 [Source:HGNC Symbol... [more]
ITSN21.037e-946.00intersectin 2 [Source:HGNC Symbol;Acc:HGNC:6184][more]
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BLAST of SH3 domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
itsn-19.604e-950.98ITSN (Intersectin) family [Source:UniProtKB/TrEMB... [more]
itsn-19.696e-950.98ITSN (Intersectin) family [Source:UniProtKB/TrEMB... [more]
itsn-11.289e-850.98ITSN (Intersectin) family [Source:UniProtKB/TrEMB... [more]
itsn-11.300e-850.98ITSN (Intersectin) family [Source:UniProtKB/TrEMB... [more]
itsn-11.715e-850.98ITSN (Intersectin) family [Source:UniProtKB/TrEMB... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Stacl1.356e-2040.21gene:FBgn0263980 transcript:FBtr0330010[more]
Stacl2.860e-2040.21gene:FBgn0263980 transcript:FBtr0475072[more]
Stacl5.438e-2030.00gene:FBgn0263980 transcript:FBtr0330011[more]
Stacl6.885e-2040.21gene:FBgn0263980 transcript:FBtr0330012[more]
Stacl7.194e-2040.21gene:FBgn0263980 transcript:FBtr0344201[more]
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BLAST of SH3 domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
stac32.291e-1032.99SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
stac32.659e-1032.99SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
stac32.659e-1032.99SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
stac1.613e-929.55SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-... [more]
stac3.874e-929.55SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STAC25.594e-1436.90SH3 and cysteine rich domain 2 [Source:NCBI gene;A... [more]
stac31.157e-1031.25SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
stac31.376e-1030.68SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
PSTPIP12.092e-950.94proline-serine-threonine phosphatase interacting p... [more]
PSTPIP12.320e-950.94proline-serine-threonine phosphatase interacting p... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Stac24.310e-1336.49SH3 and cysteine rich domain 2 [Source:MGI Symbol;... [more]
Stac1.872e-1231.03src homology three (SH3) and cysteine rich domain ... [more]
Grap21.075e-954.17GRB2-related adaptor protein 2 [Source:MGI Symbol;... [more]
Grap21.075e-954.17GRB2-related adaptor protein 2 [Source:MGI Symbol;... [more]
Itsn21.323e-946.00intersectin 2 [Source:MGI Symbol;Acc:MGI:1338049][more]
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BLAST of SH3 domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|A0JNJ1|STAC_BOVIN4.262e-1333.33SH3 and cysteine-rich domain-containing protein OS... [more]
sp|Q8R1B0|STAC2_MOUSE3.015e-1236.49SH3 and cysteine-rich domain-containing protein 2 ... [more]
sp|Q6ZMT1|STAC2_HUMAN4.001e-1236.49SH3 and cysteine-rich domain-containing protein 2 ... [more]
sp|P97306|STAC_MOUSE1.310e-1131.03SH3 and cysteine-rich domain-containing protein OS... [more]
sp|Q99469|STAC_HUMAN3.170e-1136.23SH3 and cysteine-rich domain-containing protein OS... [more]
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BLAST of SH3 domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A267G8I54.467e-2930.15SH3 domain-containing protein OS=Macrostomum ligna... [more]
A0A267G8I32.707e-2830.41SH3 domain-containing protein OS=Macrostomum ligna... [more]
A0A267GJZ94.737e-2630.87SH3 domain-containing protein OS=Macrostomum ligna... [more]
A0A1D2MY653.755e-2447.83SH3 and cysteine-rich domain-containing protein 3 ... [more]
J9K1K75.283e-2347.92SH3 domain-containing protein OS=Acyrthosiphon pis... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STAC26.440e-1134.33SH3 and cysteine rich domain 2 [Source:HGNC Symbol... [more]
STAC34.015e-1032.99SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
grap2a4.724e-944.62GRB2-related adapter protein-like [Source:NCBI gen... [more]
grap2a8.269e-934.78GRB2-related adapter protein-like [Source:NCBI gen... [more]
grap2a8.269e-934.78GRB2-related adapter protein-like [Source:NCBI gen... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000009546.12.367e-1234.52pep scaffold:Pmarinus_7.0:GL485512:1487:9666:1 gen... [more]
stac37.874e-1133.33SH3 and cysteine rich domain 3 [Source:NCBI gene;A... [more]
stac1.045e-1028.21SH3 and cysteine rich domain [Source:ZFIN;Acc:ZDB-... [more]
grb2a2.686e-846.81growth factor receptor-bound protein 2a [Source:ZF... [more]
ABI16.963e-732.89abl interactor 1 [Source:HGNC Symbol;Acc:HGNC:1132... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5
Match NameE-valueIdentityDescription
PIN31.309e-1038.46Negative regulator of actin nucleation-promoting f... [more]
LSB12.326e-1042.65Negative regulator of actin nucleation-promoting f... [more]
LSB32.620e-846.30Protein containing a C-terminal SH3 domain; binds ... [more]
YSC846.800e-843.86Actin-binding protein; involved in bundling of act... [more]
RVS1672.376e-641.51Calmodulin-binding actin-associated protein; roles... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO273843.662e-842.31Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO298641.093e-742.86Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO387103.616e-740.82Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413036.561e-740.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO297441.336e-638.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of SH3 domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
STAC25.023e-1335.90SH3 and cysteine-rich domain-containing protein 2 ... [more]
STAC21.630e-1235.90SH3 and cysteine-rich domain-containing protein 2 ... [more]
stac2.295e-1130.53SH3 and cysteine rich domain [Source:NCBI gene;Acc... [more]
stac2.498e-1130.53SH3 and cysteine rich domain [Source:NCBI gene;Acc... [more]
grap2a9.922e-1031.25growth factor receptor-bound protein 2 [Source:NCB... [more]
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BLAST of SH3 domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000039140.17.027e-1693.82SMESG000039140.1[more]
SMESG000047737.11.290e-3931.70SMESG000047737.1[more]
SMESG000038704.13.146e-744.00SMESG000038704.1[more]
SMESG000022674.15.953e-731.18SMESG000022674.1[more]
SMESG000022674.18.591e-731.18SMESG000022674.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30019497 ID=SMED30019497|Name=SH3 domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2118bp
CTCTTCCGATCTCTTTAAACAGCTGTTATTTTTTAAAACAAACATTAATT
CTGTTGCGATGGTTGCATGGTTACACGCACACAGACTCAGTTTCAACGAC
GATGCTGTACTCGTAGAATTGTTTATGAGTTTTCTATTTTGATTTTTTTT
TTAAAAAAATATATATCAATTGAATTTAAAATTTATTTATTTATTTTTCT
TCCGTAAATTCTTGAAAATCGATTTGTCAACAAATTGGGATTTATGATTG
GATTGGATTTTGGAATATCGATCAATTGATTTTTCCATGACGAAGCGATA
TTTGCGGTTCAATAGAAATCGGCAGAAATCAACCGATGAGGATGAAATTT
CAATAAACATTGATAGGAATATTCCCAGCCAAGAATCCGAAGCATGGGCA
ACGAGATATCCCACAAGAAATAACATAAAATCAAATTCAAACAAAGATAT
TTATGGACCAGTCGATGCCCAAGAACTACCAGAATCATTTAGAAATATGA
AAAGAATTTGGAAAAAAGCAGTTTTTTCTATAAAAAAAGAAACAAAAAGT
AAACCTGGTGGAGAATTTACGAAATCAGAAATTGAAATGCCAACTCCTTC
GGGAGATATTTCAAAATCAAAATCTAGCCCGGGAAATCTAGACGTTGATC
CAATTTATCTCATGCTTAGAAGTGCGGCTTACAAAGCAACCGATGGCTCC
GAGCTAGGTCCAGACGATGACAAAAATCATCAAATAGAATATGAAAGAAA
CGAAAAAGACATTCAACTTCGGGATTCATCAAACAATCTGGCTATTAATT
ATCCTGATCAAAAATTGTCTCCTAATGAAGAGCTAAGGAAAATTCCCGAT
TCTCTTTCAGGGAAATCAGTGCCCAGACGGAGATTAGACGCAAGAATGAA
GAGTTTATCTGTCGACAATCCAGAAGTAGAAATTCATGAAGAAAACGAAG
ATATTGATGACAGCATATATCATCAGTCACGGCAATTCAGTAATTCATTT
ACAAATACAAATGCAATTGAATCAAAAACTTTAGCAAATCCTTATTCAAT
GAGAAGAAAATATCTCAAAGAACAACACCGAAGCATATCAATGGAAAATG
AACACCATGCAATAGTGACATCAAGCTGTGAAAATTACCGATCAAATTCC
AGTATCAAATCCAGTGATGTCATTTCTCCTCGTCAGTCATCCCGATATAT
AAATGTAATTTCTGACGAATCGAAAAGAAACAGTCAATCTTCGGTAACGA
AGAGCAACTTAAGAACTACGAGAACAAATTGGAAAATGAAAAGTTTTTCT
GTTGATGTTCCAGATGGAGACGTTGATATTTCCGCCTCTTCTTCTCAATA
TATTTTAAAAGGAGGAAACAGTCACACGTCTTCACCAATAAGGGAGAAAT
CAAATTACTACAAATCCTCAGATTCACCAGGTCATGATAATAGGAGCTCA
CATTCAAATCTTTATTCAGCAAAAAGAGCACCAAGACCGAATTATCATAA
TCCAATTTCTCCAGAATCGCTTATTGCAAGTCATCAAGCCAGGCATAATC
CTTGTCGATATGATCCTGAATTTGACAACAATCCAGTCGATCACAAAAGA
TTGTCTACGAATTCATATGTAGTACTTTATGATTTTTACGCAAGAAGATC
AGATGAACTTGATTTAAAAGCTGGTTGGAAGGTAAATGTGCTCAACTCAT
CAGATCCGGACTGGTGGACAGGACGATGCAATGGACGTATAGGATATTTC
CCAGCAGCTTATGTTCAAAAGATTCATTATGGTAATTCAGTGTGGAAAAT
AGTTCGTGATATTTCCTTAAATGATGATGATGGAAATACATTCAAATTGA
GAAAAGGAGAGTTGTTCAACAAGGCTCACAAGATAGCGAAAGCATTCCAA
TTTGTATCAAAAGAGTCAGTTATTTGTGGTGCCCGATTGACTACGTTGGG
AAAATATTTGATGACTATATTTAAGAATTCAATGAGATAAATTATCCTTT
ATTTTGATAGATAAAATCGGAAAACATCATACCAAATATATGCATTTTAC
GGTTGACAATCGTTCCATTTTTAATATAAAATTTCACTTGTTTTAAATTT
TCAAAGAAGATCGGAAGA
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protein sequence of SMED30019497-orf-1

>SMED30019497-orf-1 ID=SMED30019497-orf-1|Name=SMED30019497-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=568bp
MTKRYLRFNRNRQKSTDEDEISINIDRNIPSQESEAWATRYPTRNNIKSN
SNKDIYGPVDAQELPESFRNMKRIWKKAVFSIKKETKSKPGGEFTKSEIE
MPTPSGDISKSKSSPGNLDVDPIYLMLRSAAYKATDGSELGPDDDKNHQI
EYERNEKDIQLRDSSNNLAINYPDQKLSPNEELRKIPDSLSGKSVPRRRL
DARMKSLSVDNPEVEIHEENEDIDDSIYHQSRQFSNSFTNTNAIESKTLA
NPYSMRRKYLKEQHRSISMENEHHAIVTSSCENYRSNSSIKSSDVISPRQ
SSRYINVISDESKRNSQSSVTKSNLRTTRTNWKMKSFSVDVPDGDVDISA
SSSQYILKGGNSHTSSPIREKSNYYKSSDSPGHDNRSSHSNLYSAKRAPR
PNYHNPISPESLIASHQARHNPCRYDPEFDNNPVDHKRLSTNSYVVLYDF
YARRSDELDLKAGWKVNVLNSSDPDWWTGRCNGRIGYFPAAYVQKIHYGN
SVWKIVRDISLNDDDGNTFKLRKGELFNKAHKIAKAFQFVSKESVICGAR
LTTLGKYLMTIFKNSMR*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000099neuron
PLANA:0000418head
PLANA:0000463cholinergic neuron
Vocabulary: INTERPRO
TermDefinition
IPR039688STAC1/2/3
IPR036028SH3-like_dom_sf
IPR013315Spectrin_alpha_SH3
IPR001452SH3_domain
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005622intracellular
Vocabulary: biological process
TermDefinition
GO:0035556intracellular signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001452SH3 domainPRINTSPR00452SH3DOMAINcoord: 484..496
score: 39.96
coord: 456..471
score: 32.93
coord: 442..452
score: 33.57
coord: 473..482
score: 36.42
IPR001452SH3 domainSMARTSM00326SH3_2coord: 442..497
e-value: 6.4E-18
score: 75.5
IPR001452SH3 domainPFAMPF00018SH3_1coord: 445..490
e-value: 1.8E-13
score: 49.8
IPR001452SH3 domainPROSITEPS50002SH3coord: 439..498
score: 23.218
NoneNo IPR availablePRINTSPR01887SPECTRNALPHAcoord: 441..460
score: 23.4
coord: 476..497
score: 46.73
coord: 461..475
score: 37.87
NoneNo IPR availableGENE3DG3DSA:2.30.30.40coord: 430..498
e-value: 1.3E-18
score: 68.3
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 1..21
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 358..390
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 86..115
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 306..325
IPR039688STAC1/2/3PANTHERPTHR15135STACcoord: 272..520
IPR036028SH3-like domain superfamilySUPERFAMILYSSF50044SH3-domaincoord: 442..498