Asparagine rich antigen
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019453 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 9
Homology
BLAST of Asparagine rich antigen vs. TrEMBL
Match: A0A068WT79 (Asparagine rich antigen OS=Echinococcus granulosus OX=6210 GN=EgrG_000524800 PE=4 SV=1) HSP 1 Score: 86.6557 bits (213), Expect = 1.536e-13 Identity = 69/181 (38.12%), Postives = 97/181 (53.59%), Query Frame = 1 Query: 190 SRVAAQIRRNKESQTLILLQNALPICLP-----------SPNQM-LEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLIS------SNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPT-TGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRS 675 SR+AA++RRN+ES L L ALP+ LP +P+++ LEKS VIR+AGQTLFL SL QVLG VP IS L TD+ +VYA+P + + W NLIG+ + + D + + PT G+ V L++L ++N P SS+ PS L ++ S S Sbjct: 190 SRLAAKLRRNQESNILFCLLRALPVSLPDTAVSEGSIKTTPSKLNLEKSGVIRMAGQTLFLYNSLSQVLGTK---AVPFISLLSKSLHGLLVHPTDST--VVYATPPLAEAI-NWPWINLIGVKLESLTD-EGKMPTRAGETVNLRVLE--------QTNSPAKSSVHNRPSTLLRSPSHS 355
BLAST of Asparagine rich antigen vs. TrEMBL
Match: W6UIA7 (Asparagine-rich antigen OS=Echinococcus granulosus OX=6210 GN=EGR_03885 PE=4 SV=1) HSP 1 Score: 86.2705 bits (212), Expect = 1.725e-13 Identity = 69/181 (38.12%), Postives = 97/181 (53.59%), Query Frame = 1 Query: 190 SRVAAQIRRNKESQTLILLQNALPICLP-----------SPNQM-LEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLIS------SNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPT-TGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRS 675 SR+AA++RRN+ES L L ALP+ LP +P+++ LEKS VIR+AGQTLFL SL QVLG VP IS L TD+ +VYA+P + + W NLIG+ + + D + + PT G+ V L++L ++N P SS+ PS L ++ S S Sbjct: 73 SRLAAKLRRNQESNILFCLLRALPVSLPDTAVSEGSIKTTPSKLNLEKSGVIRMAGQTLFLYNSLSQVLGTK---AVPFISLLSKSLHGLLVHPTDST--VVYATPPLAEAI-NWPWINLIGVKLESLTD-EGKMPTRAGETVNLRVLE--------QTNSPAKSSVHNRPSTLLRSPSHS 238
BLAST of Asparagine rich antigen vs. TrEMBL
Match: A0A3P7ESY6 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS2223 PE=4 SV=1) HSP 1 Score: 81.2629 bits (199), Expect = 3.342e-13 Identity = 59/159 (37.11%), Postives = 84/159 (52.83%), Query Frame = 1 Query: 190 SRVAAQIRRNKESQTLILLQNALPICLP-----------SPNQM-LEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFF---TDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPN-PTCEFKSNKP 618 SR+AA++RRN+ES L L ALP+ LP +P+ + LEKS VIR+AGQTLFL SL +VLG + L+S + TD+ +VYA+P + + W NLIG+ + + D G+ V L++L N PT N+P Sbjct: 15 SRLAAKMRRNQESNILFCLLRALPVSLPDTAGSEGSIKTAPSGLNLEKSGVIRMAGQTLFLYNSLSRVLGTKAVPFISLLSKSLYGLLVHPTDST--VVYATPPLAEAI-NWPWINLIGVKLESLTDEGKLPERAGETVNLRVLEQTNSPTKSSVHNRP 170
BLAST of Asparagine rich antigen vs. TrEMBL
Match: A0A0R3WN98 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 PE=4 SV=1) HSP 1 Score: 81.2629 bits (199), Expect = 3.604e-13 Identity = 59/159 (37.11%), Postives = 84/159 (52.83%), Query Frame = 1 Query: 190 SRVAAQIRRNKESQTLILLQNALPICLP-----------SPNQM-LEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFF---TDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPN-PTCEFKSNKP 618 SR+AA++RRN+ES L L ALP+ LP +P+ + LEKS VIR+AGQTLFL SL +VLG + L+S + TD+ +VYA+P + + W NLIG+ + + D G+ V L++L N PT N+P Sbjct: 15 SRLAAKMRRNQESNILFCLLRALPVSLPDTAGSEGSIKTAPSGLNLEKSGVIRMAGQTLFLYNSLSRVLGTKAVPFISLLSKSLYGLLVHPTDST--VVYATPPLAEAI-NWPWINLIGVKLESLTDEGKLPERAGETVNLRVLEQTNSPTKSSVHNRP 170
BLAST of Asparagine rich antigen vs. TrEMBL
Match: A0A068XZV3 (Asparagine rich antigen OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000524800 PE=4 SV=1) HSP 1 Score: 81.2629 bits (199), Expect = 6.694e-12 Identity = 65/173 (37.57%), Postives = 92/173 (53.18%), Query Frame = 1 Query: 190 SRVAAQIRRNKESQTLILLQNALPICLP-----------SPNQM-LEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLIS------SNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPT-TGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSV 651 SR+AA++RRN+ES L L ALP+ LP +P+++ LEKS VIR+AGQTLFL SL +VLG VP IS L TD+ +VYA+P + + W NLIG+ + + D + + PT G+ V L++L ++N P SS+ PS Sbjct: 190 SRLAAKLRRNQESNILFCLLRALPVSLPDTAVSEGSIKTTPSKLNLEKSGVIRMAGQTLFLYNSLSRVLGTR---AVPFISLLSKSLHGLLVHPTDST--VVYATPPLAEAI-NWPWINLIGVKLESLTD-EGKMPTRAGETVNLRVLE--------QTNSPAKSSIHNHPST 347
BLAST of Asparagine rich antigen vs. Planmine SMEST
Match: SMESG000022424.1 (SMESG000022424.1) HSP 1 Score: 1233.39 bits (3190), Expect = 0.000e+0 Identity = 650/654 (99.39%), Postives = 653/654 (99.85%), Query Frame = 1 Query: 82 MQPKKPDAHNCMKSRFNGMNXXXXXXXXXXXXXXXXSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINVRSNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQXXXXXXXXXXXXXXXXXXXXXXXXXTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNNVWTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKTNRPKSIHINQLKLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI 2043 MQPKKPDAHNCMKSRFNGMNIKIAIKEKKADKRKEKSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINV SNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQSSSVSSSSSMPSPSSSLSTSNYSESTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNN+WTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKT+RPKSIHINQ+KLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI Sbjct: 1 MQPKKPDAHNCMKSRFNGMNIKIAIKEKKADKRKEKSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINVLSNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQSSSVSSSSSMPSPSSSLSTSNYSESTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNNIWTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKTHRPKSIHINQMKLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI 654
BLAST of Asparagine rich antigen vs. Planmine SMEST
Match: SMESG000022424.1 (SMESG000022424.1) HSP 1 Score: 1208.36 bits (3125), Expect = 0.000e+0 Identity = 639/643 (99.38%), Postives = 642/643 (99.84%), Query Frame = 1 Query: 115 MKSRFNGMNXXXXXXXXXXXXXXXXSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINVRSNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQXXXXXXXXXXXXXXXXXXXXXXXXXTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNNVWTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKTNRPKSIHINQLKLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI 2043 MKSRFNGMNIKIAIKEKKADKRKEKSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINV SNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQSSSVSSSSSMPSPSSSLSTSNYSESTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNN+WTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKT+RPKSIHINQ+KLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI Sbjct: 1 MKSRFNGMNIKIAIKEKKADKRKEKSRVAAQIRRNKESQTLILLQNALPICLPSPNQMLEKSIVIRIAGQTLFLLKSLDQVLGMTDWLTVPLISSNFLAFFTDNIGQIVYASPNIQNVLEQHHWSNLIGISIFDIMDFKSRWPTTGDVVKLKLLANPNPTCEFKSNKPQVSSMSFSPSVLYQNCSRSNIVSKINVLSNLSMINQFIPPCSIYTVWCSTNISHTNSKLKLLLLRQIQTQSSSVSSSSSMPSPSSSLSTSNYSESTNHLVVPSSEGLPFDRSLSWPLILNQMKSEHNDPDAQFNQSKGIQKGFLVSVHDRKYQFEAVSSEFCRVVGETENDLTEQNLLDIIHIEDVIRVKSYLDSIIEKRDNNIWTPIYRILCSNERYCMVKSLAKQFSTSCSQSIILHHKIIRTDLTNEYTTKFCAYEFKKKSLPSKIFISATSSPKRKIQSVPKSTPFISSQNSSQTIFQKRKSTDQSFDSEKFSHIAENKSAFQKFFPGSNSESEKYLEKLLKPHILMTNKDLNINNSILDKDPFLPTCFERLIYKSKTDSYKTHRPKSIHINQMKLNSKSLWKDKFENESNCSASHSLESCVLTSPSPDSVGISIDDQFLWDFPDSLCELTQSNHWFDEQYQNDLELILPI 643 The following BLAST results are available for this feature:
BLAST of Asparagine rich antigen vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 0
BLAST of Asparagine rich antigen vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Asparagine rich antigen vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 0
BLAST of Asparagine rich antigen vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 0
BLAST of Asparagine rich antigen vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019453 ID=SMED30019453|Name=Asparagine rich antigen|organism=Schmidtea mediterranea sexual|type=transcript|length=2475bpback to top protein sequence of SMED30019453-orf-1 >SMED30019453-orf-1 ID=SMED30019453-orf-1|Name=SMED30019453-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=655bp MQPKKPDAHNCMKSRFNGMNIKIAIKEKKADKRKEKSRVAAQIRRNKESQback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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