NAD-dependent protein deacylase

Overview
NameNAD-dependent protein deacylase
Smed IDSMED30019307
Length (bp)1287
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of NAD-dependent protein deacylase (SMED30019307) t-SNE clustered cells

Violin plots show distribution of expression levels for NAD-dependent protein deacylase (SMED30019307) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of NAD-dependent protein deacylase (SMED30019307) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for NAD-dependent protein deacylase (SMED30019307) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30019307

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
epidermisSMED30019307h1SMcG0000954 dd_Smed_v4_13535_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30019307h1SMcG0000954 dd_Smed_v4_13535_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
photoreceptor neuronSMED30019307h1SMcG0000954 SMED30019307smed_20140614PMID:22884275
Lapan et al., 2012		whole organism asexual adult colorimetric in situ hybridization evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT4 (sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932])

HSP 1 Score: 275.789 bits (704), Expect = 1.185e-89
Identity = 132/283 (46.64%), Postives = 186/283 (65.72%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E +++  +FI+   +L+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WEK  K+++ V+QNVD LH K+G ++L ELHG   +V+C++C     R  LQE F  LNP + +E   + +APDGD  + ++ +RSF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLA  +L    G +LP +D
Sbjct:   32 FVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAE--AHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLID 312
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT4 (sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932])

HSP 1 Score: 140.198 bits (352), Expect = 5.614e-40
Identity = 61/103 (59.22%), Postives = 78/103 (75.73%), Query Frame = 1 
Query:  136 VTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHG 444
            +TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WEK  K+++ V+QNVD LH K+G ++L ELHG
Sbjct:    1 MTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHG 103
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 120.553 bits (301), Expect = 2.669e-30
Identity = 82/279 (29.39%), Postives = 132/279 (47.31%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPK 894
            + DF KF +    +++++GAGVS ESG+P +R    G Y  K  +  +    L    N  R W   ++   +  S  PN  H  I + E    K+ +    ++QN+D LH+K+G K L+E+HG+  +  C +C                  N++S I      K AP+     +D  I   K P C +  C G+L+P +++FG+N+ PAI +E+ + L H  D  L +GTS  VY +     Q     +P+   N   T A +   +  +G  G  LP+
Sbjct:   40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRG--AGGYWRKW-QAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAE-------------NYKSPICPALSGKGAPEPG--TQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC-DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPE 299
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 112.849 bits (281), Expect = 1.241e-27
Identity = 79/270 (29.26%), Postives = 128/270 (47.41%), Query Frame = 1 
Query:   79 TEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASY 858
            +  + DF KF +    +++++GAGVS ESG+P +R    G Y  K  +  +    L    N  R W   ++   +  S  PN  H  I + E    K+ +    ++QN+D LH+K+G K L+E+HG+  +  C +C                  N++S I      K AP+     +D  I   K P C +  C G+L+P +++FG+N+ PAI +E+ + L H  D  L +GTS  VY +     Q     +P+   N   T A +  S+
Sbjct:   37 SSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRG--AGGYWRKW-QAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAE-------------NYKSPICPALSGKGAPEPG--TQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHC-DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFSH 287
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Match: SIRT5 (sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933])

HSP 1 Score: 110.923 bits (276), Expect = 5.057e-27
Identity = 77/274 (28.10%), Postives = 124/274 (45.26%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPK 894
            + DF KF +    +++++GAGVS ESG+P +R    G Y  K  +  +    L    N  R W   ++   +  S  PN  H  I + E    K+ +    ++QN+D LH+K+G K L+E+HG+  +  C +C                  N++S I     A  G    E              C G+L+P +++FG+N+ PAI +E+ + L H  D  L +GTS  VY +     Q     +P+   N   T A +   +  +G  G  LP+
Sbjct:   40 MADFRKFFAKAKHIVIISGAGVSAESGVPTFRG--AGGYWRKW-QAQDLATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAE-------------NYKSPICP---ALSGKGCEEA------------GCGGLLRPHVVWFGENLDPAILEEVDRELAHC-DLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPE 281
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 249.98 bits (637), Expect = 2.297e-80
Identity = 122/284 (42.96%), Postives = 171/284 (60.21%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSE-IDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            KFVP  A      ++ F   I +  KL+V++GAG+STESGIPDYRSKDVGLYA    +P+ +Q ++RS+  RQRYW+RN+  WP F    PNI H  + KWE   +  + ++QNVD LH K+G K + ELHG+  QV C  CD+  SR   Q+     NP F+ E +   ++APDGD I+     + F+ P+C  C G++K D+ FFG+NV           ++  DG+L LGTSL V S FR +  A+    PI I+NIG TRAD +A+ +L   +  VL ++
Sbjct:    4 KFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM 287
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 244.973 bits (624), Expect = 2.152e-78
Identity = 122/286 (42.66%), Postives = 171/286 (59.79%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTES--GIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSE-IDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            KFVP  A      ++ F   I +  KL+V++GAG+STES  GIPDYRSKDVGLYA    +P+ +Q ++RS+  RQRYW+RN+  WP F    PNI H  + KWE   +  + ++QNVD LH K+G K + ELHG+  QV C  CD+  SR   Q+     NP F+ E +   ++APDGD I+     + F+ P+C  C G++K D+ FFG+NV           ++  DG+L LGTSL V S FR +  A+    PI I+NIG TRAD +A+ +L   +  VL ++
Sbjct:    4 KFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM 289
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.2 (NAD-dependent protein deacylase sir-2.2 [Source:UniProtKB/Swiss-Prot;Acc:Q20480])

HSP 1 Score: 245.358 bits (625), Expect = 2.190e-78
Identity = 122/286 (42.66%), Postives = 171/286 (59.79%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTES--GIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSE-IDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            KFVP  A      ++ F   I +  KL+V++GAG+STES  GIPDYRSKDVGLYA    +P+ +Q ++RS+  RQRYW+RN+  WP F    PNI H  + KWE   +  + ++QNVD LH K+G K + ELHG+  QV C  CD+  SR   Q+     NP F+ E +   ++APDGD I+     + F+ P+C  C G++K D+ FFG+NV           ++  DG+L LGTSL V S FR +  A+    PI I+NIG TRAD +A+ +L   +  VL ++
Sbjct:    9 KFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM 294
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.3 (NAD-dependent protein deacylase sir-2.3 [Source:UniProtKB/Swiss-Prot;Acc:Q20481])

HSP 1 Score: 237.654 bits (605), Expect = 1.402e-75
Identity = 113/284 (39.79%), Postives = 169/284 (59.51%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSE-IDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            K+VP         ++ F   + +  KL+++TGAG+STESGIPDYRSKDVGLY      P+ +Q F++S + RQRYW+R+Y  WP F+   PN  H  + KWE  +K  + ++QNVD LH K+G K + ELHGN  QV C +C++  +R   Q+     NP F+ + +   +   D D  +     + FK P+C  C G++K D+  FG+N+     ++    ++  +G+L LGTSLEV S ++IV  AH  N PI I+NIG TRAD +A+ +L   +  VL ++
Sbjct:    4 KYVPHTTELCENSLKKFKSLVGTVDKLLIITGAGISTESGIPDYRSKDVGLYTKTALEPIYFQDFMKSKKCRQRYWSRSYLNWPRFAQALPNFNHYALSKWEAANKFHWLITQNVDGLHLKAGSKMITELHGNALQVKCTSCEYIETRQTYQDRLNYANPGFKEQFVSPGQQELDADTALPLGSEQGFKIPECLNCGGLMKTDVTLFGENLNTDKIKVCGKKVNECNGVLTLGTSLEVLSGYQIVNHAHMQNKPIFIVNIGPTRADQMATMKLDYRISDVLKEM 287
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Match: sir-2.1 (NAD-dependent protein deacetylase sir-2.1 [Source:UniProtKB/Swiss-Prot;Acc:Q21921])

HSP 1 Score: 92.8189 bits (229), Expect = 5.394e-20
Identity = 68/255 (26.67%), Postives = 118/255 (46.27%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSR----PMEYQVFLRSHENRQRYWARN-----YFGWPLF-SSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIIN 822
            + D  +   ++  ++V+TGAGVS   GIPD+RSKD G+YA   S     P    +F        RY+  N      F   +F     P+++H  I + E   ++    +QN+D L  ++G+K+++E HG+  +  C  C                               DG+ I E+ L     H  C +C+G++KP+I+FFG+++     + V    H  D ++ +G+SL+V     ++    + N+P  +IN
Sbjct:  135 LADAVELFKTKKHILVLTGAGVSVSCGIPDFRSKD-GIYARLRSEFPDLPDPTAMF------DIRYFRENPAPFYNFAREIFPGQFVPSVSHRFIKELETSGRLLRNYTQNIDTLEHQTGIKRVVECHGSFSKCTCTRCGQKY---------------------------DGNEIREEVLAMRVAH--CKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHKVDLIVVIGSSLKV-RPVALIPHCVDKNVPQILIN 352
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070852)

HSP 1 Score: 261.151 bits (666), Expect = 2.660e-84
Identity = 126/285 (44.21%), Postives = 193/285 (67.72%), Query Frame = 1 
Query:   43 QMKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            + ++VP     + + I+    F+ S+  ++V+TGAG+STESGIPDYRS+ VGLYA    +P+++  F++S   R+RYWARN+ GWP FS+ +PN  H  + ++E+E ++   V+QNVD LH K+G + ++E+HG+ + V C++C++ I RHE Q I   LNP F+   D   I PDGD  I  + I +F+ P+C +C G LKP+I+FFGD+VP    + +  +++ SDGLL LG+SL V+S +R+V Q  +L +P+GI+NIG+TRAD LA  ++    G V+PKL
Sbjct:   20 RQEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDM--IRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKL 302
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070851)

HSP 1 Score: 206.068 bits (523), Expect = 5.513e-64
Identity = 99/219 (45.21%), Postives = 149/219 (68.04%), Query Frame = 1 
Query:  241 FLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            F++S   R+RYWARN+ GWP FS+ +PN  H  + ++E+E ++   V+QNVD LH K+G + ++E+HG+ + V C++C++ I RHE Q I   LNP F+   D   I PDGD  I  + I +F+ P+C +C G LKP+I+FFGD+VP    + +  +++ SDGLL LG+SL V+S +R+V Q  +L +P+GI+NIG+TRAD LA  ++    G V+PKL
Sbjct:    3 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDM--IRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKL 219
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt4 (gene:FBgn0029783 transcript:FBtr0070850)

HSP 1 Score: 206.068 bits (523), Expect = 5.513e-64
Identity = 99/219 (45.21%), Postives = 149/219 (68.04%), Query Frame = 1 
Query:  241 FLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            F++S   R+RYWARN+ GWP FS+ +PN  H  + ++E+E ++   V+QNVD LH K+G + ++E+HG+ + V C++C++ I RHE Q I   LNP F+   D   I PDGD  I  + I +F+ P+C +C G LKP+I+FFGD+VP    + +  +++ SDGLL LG+SL V+S +R+V Q  +L +P+GI+NIG+TRAD LA  ++    G V+PKL
Sbjct:    3 FVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDM--IRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKL 219
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0083882)

HSP 1 Score: 91.6633 bits (226), Expect = 4.520e-20
Identity = 68/218 (31.19%), Postives = 104/218 (47.71%), Query Frame = 1 
Query:  124 KLIVVTGAGVSTESGIPDYRSKDVGLYAS--KTSRPMEYQVFLRSH--ENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQ--LIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            K++ + GAG+ST +GIPD+RS   GLY++  K   P    +F   +  +N   ++A     +P   S  P  AH  I     +  +    +QN+D L + +GL +  +IE HG+ H   CI C                    R E D + +  +   I  D+L      P C KC+G++KPDI+FFG+N+P       +      D L+ +GTSLEV
Sbjct:   49 KIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYP--GSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKC--------------------RKEYDMDWMKAE---IFADRL------PKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEV 235
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Match: Sirt2 (gene:FBgn0038788 transcript:FBtr0344243)

HSP 1 Score: 91.6633 bits (226), Expect = 4.520e-20
Identity = 68/218 (31.19%), Postives = 104/218 (47.71%), Query Frame = 1 
Query:  124 KLIVVTGAGVSTESGIPDYRSKDVGLYAS--KTSRPMEYQVFLRSH--ENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQ--LIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            K++ + GAG+ST +GIPD+RS   GLY++  K   P    +F   +  +N   ++A     +P   S  P  AH  I     +  +    +QN+D L + +GL +  +IE HG+ H   CI C                    R E D + +  +   I  D+L      P C KC+G++KPDI+FFG+N+P       +      D L+ +GTSLEV
Sbjct:   49 KIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFFALAKELYP--GSFIPTPAHYFIRLLNDKGLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFHTNHCIKC--------------------RKEYDMDWMKAE---IFADRL------PKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQDCDLLIIMGTSLEV 235
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 279.641 bits (714), Expect = 1.989e-91
Identity = 132/283 (46.64%), Postives = 184/283 (65.02%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            +FVP      +  ++    FIS   +L V++GAG+STESGIPDYRS+ VGLYA    RPM++  F+RS ++RQRYWARNY GWP FSS +PN AH  +  WE++ K+ + V+QNVD LH K+G ++L ELHG+TH+V+C++C     R ELQ+ FT LNP +  E     +APDGD  +E++ + +F+ P C  C G+LKP++ FFGD V   T   V   +  SD +L  G+SL+V+S +R +  A E  +PI I+NIG TRAD L   R+    G VLP +
Sbjct:   27 QFVPASGSFDSSALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRLTELHGSTHRVVCLDCGELTLRAELQKRFTALNPGW--EATACAVAPDGDVFLEEEQVLNFRVPACNACGGVLKPEVTFFGDVVKRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASERKLPIAIVNIGATRADHLTDIRVSARCGEVLPAI 307
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 279.641 bits (714), Expect = 1.989e-91
Identity = 132/283 (46.64%), Postives = 184/283 (65.02%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            +FVP      +  ++    FIS   +L V++GAG+STESGIPDYRS+ VGLYA    RPM++  F+RS ++RQRYWARNY GWP FSS +PN AH  +  WE++ K+ + V+QNVD LH K+G ++L ELHG+TH+V+C++C     R ELQ+ FT LNP +  E     +APDGD  +E++ + +F+ P C  C G+LKP++ FFGD V   T   V   +  SD +L  G+SL+V+S +R +  A E  +PI I+NIG TRAD L   R+    G VLP +
Sbjct:   27 QFVPASGSFDSSALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRLTELHGSTHRVVCLDCGELTLRAELQKRFTALNPGW--EATACAVAPDGDVFLEEEQVLNFRVPACNACGGVLKPEVTFFGDVVKRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASERKLPIAIVNIGATRADHLTDIRVSARCGEVLPAI 307
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 279.641 bits (714), Expect = 1.989e-91
Identity = 132/283 (46.64%), Postives = 184/283 (65.02%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            +FVP      +  ++    FIS   +L V++GAG+STESGIPDYRS+ VGLYA    RPM++  F+RS ++RQRYWARNY GWP FSS +PN AH  +  WE++ K+ + V+QNVD LH K+G ++L ELHG+TH+V+C++C     R ELQ+ FT LNP +  E     +APDGD  +E++ + +F+ P C  C G+LKP++ FFGD V   T   V   +  SD +L  G+SL+V+S +R +  A E  +PI I+NIG TRAD L   R+    G VLP +
Sbjct:   27 QFVPASGSFDSSALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRLTELHGSTHRVVCLDCGELTLRAELQKRFTALNPGW--EATACAVAPDGDVFLEEEQVLNFRVPACNACGGVLKPEVTFFGDVVKRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASERKLPIAIVNIGATRADHLTDIRVSARCGEVLPAI 307
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 247.284 bits (630), Expect = 3.029e-79
Identity = 116/249 (46.59%), Postives = 164/249 (65.86%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHE 795
            +FVP      +  ++    FIS   +L V++GAG+STESGIPDYRS+ VGLYA    RPM++  F+RS ++RQRYWARNY GWP FSS +PN AH  +  WE++ K+ + V+QNVD LH K+G ++L ELHG+TH+V+C++C     R ELQ+ FT LNP +  E     +APDGD  +E++ + +F+ P C  C G+LKP++ FFGD V   T   V   +  SD +L  G+SL+V+S +R +  A E
Sbjct:   27 QFVPASGSFDSSALEQLQAFISQASRLFVISGAGLSTESGIPDYRSEGVGLYARTNRRPMQHSEFVRSEKSRQRYWARNYVGWPQFSSHQPNSAHLALRDWEEKGKLHWLVTQNVDALHLKAGQQRLTELHGSTHRVVCLDCGELTLRAELQKRFTALNPGW--EATACAVAPDGDVFLEEEQVLNFRVPACNACGGVLKPEVTFFGDVVKRNTVHFVHNKLAESDAVLVAGSSLQVFSGYRFLLAASE 273
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:436878])

HSP 1 Score: 92.8189 bits (229), Expect = 1.011e-20
Identity = 71/282 (25.18%), Postives = 125/282 (44.33%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEY-QVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDE 903
            +  F +  +    + ++TGAGVS ESG+P +R    G +    ++ +   + F R   +    W   ++   +  S  PN AH  I + E    ++ +    ++QN+D LH ++G K + E+HG+  +  C++C              E+  N +S I      K APD +   ++  I     P C +  C G+L+P +++FG+ + +     V+  +   D  L +GTS  VY +     Q     +P+   N+  T A     Y  +G  G  LP   E
Sbjct:   36 LTAFREHFAKAKHIAIITGAGVSAESGVPTFRGPG-GFWRKWQAQDLATPEAFSR---DPSLVWEFYHYRREVMRSKMPNPAHLAIAECEARLGQQGRSVVIITQNIDELHHRAGSKHVYEIHGSLFKTRCMSCG-------------EVKANHKSPICPALDGKGAPDPN--TKEARIPVELLPRCERKSCNGLLRPHVVWFGETLDSDILTAVERELEKCDLCLVVGTSSIVYPAAMFAPQVASRGVPVAEFNMECTPATQRFKYHFEGPCGSTLPPALE 298
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: sirt4 (sirtuin 4 [Source:NCBI gene;Acc:733911])

HSP 1 Score: 277.715 bits (709), Expect = 2.278e-90
Identity = 131/283 (46.29%), Postives = 181/283 (63.96%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            +FVP C  P    ++    F+S   +L V+TGAG+STESGIPDYRS+ VGLY+    RP+++  F++S   R+RYWARN+ GWP FSS  PN AH  +CKWE+  ++ + V+QNVD LH K+G  +L ELHG TH+VIC+ C     R ELQE F  LNP++  +   + +APDGD  + D+ +  F+ P C KC GILKP + FFGD V       +   +  +D +L +G+SL+VYS +R    A EL++PI I+NIG TRAD LA  ++    G VLP +
Sbjct:   30 EFVPACPPPNPHQVEQLQDFVSQSQRLFVMTGAGISTESGIPDYRSEGVGLYSRTERRPIQHSEFVQSQAARRRYWARNFVGWPSFSSHEPNSAHVNLCKWERAGRLHWLVTQNVDALHTKAGQCRLSELHGCTHRVICLGCQTVTKRSELQERFLNLNPSWNEQA--HGLAPDGDVFLTDEQVSDFQVPACTKCGGILKPQVTFFGDTVNRGFVFSIYEQMKQADAMLIVGSSLQVYSGYRFALNAKELHLPIAILNIGPTRADHLAKVKVSARCGDVLPHI 310
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: lin28a (lin-28 homolog A [Source:Xenbase;Acc:XB-GENE-491384])

HSP 1 Score: 107.457 bits (267), Expect = 1.134e-25
Identity = 72/280 (25.71%), Postives = 128/280 (45.71%), Query Frame = 1 
Query:   79 TEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            + ++ DF +  +    + V+TGAGVS ESG+P +R         +       + F R   N  R W   ++   +  +  PN AH  I + E    K+ +    ++QN+D LH+K+G + L E+HG+  +  C +C               +  N++S I      K AP+ D  ++D  I   + P C +  C G+L+P++++FG+ + +     V+  +   D  + +GTS  VY +     Q     +P+   N+  T A    ++  +G  G  LP
Sbjct:   36 SSNLADFREAFAKAKHIAVITGAGVSAESGVPTFRGAGGYWRKWQAQHLATPEAFAR---NPSRVWEFYHYRREVMLTKNPNPAHLAIAECETRLRKQGRKLVVITQNIDELHRKAGSRNLFEIHGSLFKTRCTSCG-------------SVKENYKSPICPALAGKGAPEPD--VQDAKIPVEQLPRCDENGCNGLLRPNVVWFGETLDSNLLGEVEKELEICDLCVVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTSFTFHFQGPCGTTLP 297
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: tspear (thrombospondin-type laminin G domain and EAR repeats [Source:Xenbase;Acc:XB-GENE-6050978])

HSP 1 Score: 95.5153 bits (236), Expect = 1.791e-20
Identity = 67/241 (27.80%), Postives = 109/241 (45.23%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYF---GWPLF--------SSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQE-IFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCK-----GILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            I D  K +    K+IV+TGAGVS   GIPD+RS+D G+YA          V      N Q  +   YF     P F           +P++ H  I   +KE K+    +QN+D L + +G++++I+ HG+  +  C+ C + +    ++E IF ++ P                               C +C       I+KPDI+FFG+N+P      ++   +  D L+ +G+SL+V
Sbjct:  131 IDDAVKLLQESKKIIVLTGAGVSVSCGIPDFRSRD-GIYA-------RLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVDCEAVREDIFNQIVPR------------------------------CPRCSSDEPLAIMKPDIVFFGENLPEQFHRAMKYDKNEVDLLIVIGSSLKV 333
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: tspear (thrombospondin-type laminin G domain and EAR repeats [Source:Xenbase;Acc:XB-GENE-6050978])

HSP 1 Score: 95.1301 bits (235), Expect = 1.826e-20
Identity = 67/241 (27.80%), Postives = 109/241 (45.23%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYF---GWPLF--------SSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQE-IFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCK-----GILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            I D  K +    K+IV+TGAGVS   GIPD+RS+D G+YA          V      N Q  +   YF     P F           +P++ H  I   +KE K+    +QN+D L + +G++++I+ HG+  +  C+ C + +    ++E IF ++ P                               C +C       I+KPDI+FFG+N+P      ++   +  D L+ +G+SL+V
Sbjct:  117 IDDAVKLLQESKKIIVLTGAGVSVSCGIPDFRSRD-GIYA-------RLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVDCEAVREDIFNQIVPR------------------------------CPRCSSDEPLAIMKPDIVFFGENLPEQFHRAMKYDKNEVDLLIVIGSSLKV 319
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Match: tspear (thrombospondin-type laminin G domain and EAR repeats [Source:Xenbase;Acc:XB-GENE-6050978])

HSP 1 Score: 95.1301 bits (235), Expect = 2.324e-20
Identity = 67/241 (27.80%), Postives = 109/241 (45.23%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYF---GWPLF--------SSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQE-IFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCK-----GILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            I D  K +    K+IV+TGAGVS   GIPD+RS+D G+YA          V      N Q  +   YF     P F           +P++ H  I   +KE K+    +QN+D L + +G++++I+ HG+  +  C+ C + +    ++E IF ++ P                               C +C       I+KPDI+FFG+N+P      ++   +  D L+ +G+SL+V
Sbjct:  177 IDDAVKLLQESKKIIVLTGAGVSVSCGIPDFRSRD-GIYA-------RLAVDFPDLPNPQAMFDIEYFRKDPRPFFKFAKEIFPGQFQPSLCHRFIAMLDKEEKLLRNYTQNIDTLEQVAGIEKIIQCHGSFAEASCLVCKYKVDCEAVREDIFNQIVPR------------------------------CPRCSSDEPLAIMKPDIVFFGENLPEQFHRAMKYDKNEVDLLIVIGSSLKV 379
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt4 (sirtuin 4 [Source:MGI Symbol;Acc:MGI:1922637])

HSP 1 Score: 281.952 bits (720), Expect = 5.680e-92
Identity = 136/283 (48.06%), Postives = 187/283 (66.08%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E I++  +FIS   KL+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD LH K+G ++L ELHG  H+V+C+NC    +R  LQE F  LNP++ +E     +APDGD  + ++ +RSF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLA  +L    G +LP +D
Sbjct:   29 FVPPSPPLDPEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEA--QGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLLVVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRCGELLPLID 309
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt4 (sirtuin 4 [Source:MGI Symbol;Acc:MGI:1922637])

HSP 1 Score: 281.952 bits (720), Expect = 5.680e-92
Identity = 136/283 (48.06%), Postives = 187/283 (66.08%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E I++  +FIS   KL+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD LH K+G ++L ELHG  H+V+C+NC    +R  LQE F  LNP++ +E     +APDGD  + ++ +RSF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLA  +L    G +LP +D
Sbjct:   29 FVPPSPPLDPEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEA--QGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLLVVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRCGELLPLID 309
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 112.464 bits (280), Expect = 1.683e-27
Identity = 80/282 (28.37%), Postives = 132/282 (46.81%), Query Frame = 1 
Query:   79 TEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEK----ESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPK 894
            + ++ DF K  ++   + +++GAGVS ESG+P +R         +       Q F R   N  + W   ++   +  S  PN  H  I + E     + +    ++QN+D LH+K+G K L+E+HG   +  C +C  T++             N+RS I      K AP+ +   +D  I   K P C +  C G+L+P +++FG+N+ PAI +E+ + L    D  L +GTS  VY +     Q     +P+   N+  T A D   +   G  G  LP+
Sbjct:   37 SSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFAR---NPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCG-TVAE------------NYRSPICPALAGKGAPEPE--TQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA-LCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPE 299
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 112.464 bits (280), Expect = 1.683e-27
Identity = 80/282 (28.37%), Postives = 132/282 (46.81%), Query Frame = 1 
Query:   79 TEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEK----ESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPK 894
            + ++ DF K  ++   + +++GAGVS ESG+P +R         +       Q F R   N  + W   ++   +  S  PN  H  I + E     + +    ++QN+D LH+K+G K L+E+HG   +  C +C  T++             N+RS I      K AP+ +   +D  I   K P C +  C G+L+P +++FG+N+ PAI +E+ + L    D  L +GTS  VY +     Q     +P+   N+  T A D   +   G  G  LP+
Sbjct:   37 SSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFAR---NPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCG-TVAE------------NYRSPICPALAGKGAPEPE--TQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA-LCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATDRFRFHFPGPCGKTLPE 299
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Match: Sirt5 (sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596])

HSP 1 Score: 104.375 bits (259), Expect = 6.897e-25
Identity = 76/266 (28.57%), Postives = 126/266 (47.37%), Query Frame = 1 
Query:   79 TEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEK----ESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNV-PAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADD 846
            + ++ DF K  ++   + +++GAGVS ESG+P +R         +       Q F R   N  + W   ++   +  S  PN  H  I + E     + +    ++QN+D LH+K+G K L+E+HG   +  C +C  T++             N+RS I      K AP+ +   +D  I   K P C +  C G+L+P +++FG+N+ PAI +E+ + L    D  L +GTS  VY +     Q     +P+   N+  T A D
Sbjct:   37 SSNMADFRKCFANAKHIAIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPQAFAR---NPSQVWEFYHYRREVMRSKEPNPGHLAIAQCEARLRDQGRRVVVITQNIDELHRKAGTKNLLEIHGTLFKTRCTSCG-TVAE------------NYRSPICPALAGKGAPEPE--TQDARIPVDKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELA-LCDLCLVVGTSSVVYPAAMFAPQVASRGVPVAEFNMETTPATD 283
[Close]
BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q8R216|SIR4_MOUSE (NAD-dependent protein lipoamidase sirtuin-4, mitochondrial OS=Mus musculus OX=10090 GN=Sirt4 PE=1 SV=3)

HSP 1 Score: 281.952 bits (720), Expect = 3.973e-91
Identity = 136/283 (48.06%), Postives = 187/283 (66.08%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E I++  +FIS   KL+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD LH K+G ++L ELHG  H+V+C+NC    +R  LQE F  LNP++ +E     +APDGD  + ++ +RSF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLA  +L    G +LP +D
Sbjct:   29 FVPPSPPLDPEKIKELQRFISLSKKLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHIDFVRSAPVRQRYWARNFVGWPQFSSHQPNPAHWALSNWERLGKLHWLVTQNVDALHSKAGSQRLTELHGCMHRVLCLNCGEQTARRVLQERFQALNPSWSAEA--QGVAPDGDVFLTEEQVRSFQVPCCDRCGGPLKPDVVFFGDTVNPDKVDFVHRRVKEADSLLVVGSSLQVYSGYRFILTAREQKLPIAILNIGPTRSDDLACLKLDSRCGELLPLID 309
[Close]
BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q1JQC6|SIR4_BOVIN (NAD-dependent protein lipoamidase sirtuin-4, mitochondrial OS=Bos taurus OX=9913 GN=SIRT4 PE=2 SV=1)

HSP 1 Score: 276.174 bits (705), Expect = 3.979e-89
Identity = 132/283 (46.64%), Postives = 187/283 (66.08%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E +++  +FI+   +L+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD LH K+G ++L ELHG  H+V+C++C     R  LQE F  LNP + +E   + +APDGD  + ++ ++SF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLAS +L    G +LP +D
Sbjct:   33 FVPPSPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPVRQRYWARNFVGWPQFSSRQPNPAHWALSNWERLGKLHWLVTQNVDALHTKAGSQRLTELHGCMHRVLCLDCGEQTPRGVLQERFQVLNPTWSAEA--HGLAPDGDVFLTEEEVQSFQVPSCSRCGGPLKPDVVFFGDTVKPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAREKKLPIVILNIGPTRSDDLASLKLDSRCGELLPLID 313
[Close]
BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q9Y6E7|SIR4_HUMAN (NAD-dependent protein lipoamidase sirtuin-4, mitochondrial OS=Homo sapiens OX=9606 GN=SIRT4 PE=1 SV=1)

HSP 1 Score: 275.789 bits (704), Expect = 5.689e-89
Identity = 132/283 (46.64%), Postives = 186/283 (65.72%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP       E +++  +FI+   +L+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH  +  WEK  K+++ V+QNVD LH K+G ++L ELHG   +V+C++C     R  LQE F  LNP + +E   + +APDGD  + ++ +RSF+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R +  A E  +PI I+NIG TR+DDLA  +L    G +LP +D
Sbjct:   32 FVPASPPLDPEKVKELQRFITLSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAE--AHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLID 312
[Close]
BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q8IRR5|SIR4_DROME (NAD-dependent protein deacylase Sirt4 OS=Drosophila melanogaster OX=7227 GN=Sirt4 PE=2 SV=2)

HSP 1 Score: 261.151 bits (666), Expect = 2.666e-83
Identity = 126/285 (44.21%), Postives = 193/285 (67.72%), Query Frame = 1 
Query:   43 QMKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            + ++VP     + + I+    F+ S+  ++V+TGAG+STESGIPDYRS+ VGLYA    +P+++  F++S   R+RYWARN+ GWP FS+ +PN  H  + ++E+E ++   V+QNVD LH K+G + ++E+HG+ + V C++C++ I RHE Q I   LNP F+   D   I PDGD  I  + I +F+ P+C +C G LKP+I+FFGD+VP    + +  +++ SDGLL LG+SL V+S +R+V Q  +L +P+GI+NIG+TRAD LA  ++    G V+PKL
Sbjct:   20 RQEYVPHHKPVVEDDIKRLEDFLLSKPNVLVLTGAGISTESGIPDYRSEGVGLYARSNHKPVQHMEFVKSSAVRKRYWARNFVGWPKFSATQPNATHHALARFEREERVQAVVTQNVDRLHTKAGSRNVVEVHGSGYVVKCLSCEYRIDRHEFQSILASLNPAFKDAPDM--IRPDGDVEIPLEYIENFRIPECTQCGGDLKPEIVFFGDSVPRPRVDQIAGMVYNSDGLLVLGSSLLVFSGYRVVLQTKDLKLPVGIVNIGETRADHLADIKISAKCGDVIPKL 302
[Close]
BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Match: sp|Q20480|SIR41_CAEEL (NAD-dependent protein deacylase sir-2.2 OS=Caenorhabditis elegans OX=6239 GN=sir-2.2 PE=1 SV=1)

HSP 1 Score: 249.98 bits (637), Expect = 2.922e-79
Identity = 122/284 (42.96%), Postives = 171/284 (60.21%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSE-IDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
            KFVP  A      ++ F   I +  KL+V++GAG+STESGIPDYRSKDVGLYA    +P+ +Q ++RS+  RQRYW+RN+  WP F    PNI H  + KWE   +  + ++QNVD LH K+G K + ELHG+  QV C  CD+  SR   Q+     NP F+ E +   ++APDGD I+     + F+ P+C  C G++K D+ FFG+NV           ++  DG+L LGTSL V S FR +  A+    PI I+NIG TRAD +A+ +L   +  VL ++
Sbjct:    4 KFVPEAAELCENSLKKFISLIGTVDKLLVISGAGISTESGIPDYRSKDVGLYARIAHKPIYFQDYMRSNRCRQRYWSRNFLAWPRFGQAAPNINHYALSKWEASDRFQWLITQNVDGLHLKAGSKMVTELHGSALQVKCTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGGLMKTDVTFFGENVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFIVNIGPTRADHMATMKLDYKISDVLKEM 287
[Close]
BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: E2ADS2 (NAD-dependent deacetylase sirtuin-4 OS=Camponotus floridanus OX=104421 GN=EAG_10407 PE=4 SV=1)

HSP 1 Score: 296.59 bits (758), Expect = 1.545e-94
Identity = 144/285 (50.53%), Postives = 188/285 (65.96%), Query Frame = 1 
Query:   43 QMKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKL 897
             + FVP C    TE ++   +FI    +L ++TGAG+STESGIPDYRS +VGLYA    +P+ Y+ F  S   R+RYWARNY GWP FSS++PNI HE++   E   K+   V+QNVDNLH K+G K++IELHG   +++C NCD  I RHELQE+F +LNP+  +      I PDGD  +    + +F  P C  C GILKPDIIFFG+N+P    E V+  I  SD LL LGTSL  +SS+RIV QA E N PI I+NIGKTRAD+  + +L+G  G +L K+
Sbjct:   23 NLAFVPKCNPTTTEDVRKLKEFIDKHHRLCILTGAGISTESGIPDYRSAEVGLYARSNHKPILYKEFCNSEAIRRRYWARNYVGWPRFSSLKPNITHEILRDLEYVGKVECIVTQNVDNLHSKAGSKKVIELHGTAFRIMCFNCDHKIYRHELQEVFQKLNPSMVATTQM--IRPDGDVELSQAQVENFNVPACDNCGGILKPDIIFFGENIPRNIVEKVKNNIENSDALLILGTSLATFSSYRIVLQAVEANKPIAIVNIGKTRADEFMNLKLEGRCGDILSKV 305
[Close]
BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A3B4A6T5 (NAD-dependent protein deacylase OS=Periophthalmus magnuspinnatus OX=409849 PE=3 SV=1)

HSP 1 Score: 294.278 bits (752), Expect = 7.670e-94
Identity = 136/281 (48.40%), Postives = 190/281 (67.62%), Query Frame = 1 
Query:   46 MKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVL 888
            + FVP C+    ++++    F+S    L V+TGAG+STESGIPDYRS++VGLYA  T RPME+  F+RS ++RQRYWARN+ GWP FSS +PN+AH V+ +WE+  K+ + V+QNVD LH K+G K+L ELHG TH+VIC+ C    +R +LQ  F  LNP++ +      +APDGD  +E+  ++ F+ P C +C G+LKPD+ FFGD V     + V   +  SD +L +G+SL+VYS +R V  A++  IP+ IINIG TRAD LA  ++ G  G VL
Sbjct:   23 LNFVPPCSTTDVQYVEQLQDFVSRASHLFVMTGAGLSTESGIPDYRSENVGLYARTTRRPMEHMEFIRSAKSRQRYWARNFVGWPQFSSHQPNVAHRVLQQWEERGKLHWLVTQNVDALHSKAGQKRLTELHGCTHRVICLGCGDISAREDLQRHFEALNPDWTAHA--GAVAPDGDVFLEEDQVQYFRVPSCERCGGVLKPDVTFFGDTVNKTKVQFVHERLAESDAVLVVGSSLQVYSGYRFVLFANDRKIPVAIINIGSTRADHLAQIKVSGRCGEVL 301
[Close]
BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: G5B780 (NAD-dependent ADP-ribosyltransferase sirtuin-4 (Fragment) OS=Heterocephalus glaber OX=10181 GN=GW7_05271 PE=3 SV=1)

HSP 1 Score: 291.967 bits (746), Expect = 9.493e-93
Identity = 136/283 (48.06%), Postives = 189/283 (66.78%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP C     E +++F +FI+   KL+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  FLRS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD+LH K+G ++L ELHG  H+V+C++C     R  LQ+ F  LNP + +E     +APDGD  + D+ +R+F+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R V  A +  IPI I+NIG+TR+DDLA  +L    G +LP +D
Sbjct:   32 FVPPCPPLSPEKVREFQRFITLSKKLLVMTGAGISTESGIPDYRSEKVGLYARNARRPIQHSDFLRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWERLGKLHWLVTQNVDSLHTKAGSQRLTELHGCMHRVLCLSCGAQTPRGALQQRFQVLNPTWGAEA--QGLAPDGDVFLSDEQVRTFQVPSCLRCGGPLKPDVVFFGDTVDPAKVDFVHKRVKEADALLVVGSSLQVYSGYRFVLTARDQKIPIAILNIGRTRSDDLACLKLSSRCGELLPLID 312
[Close]
BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: A0A0P6JFX2 (NAD-dependent protein lipoamidase sirtuin-4, mitochondrial OS=Heterocephalus glaber OX=10181 GN=SIRT4 PE=3 SV=1)

HSP 1 Score: 291.967 bits (746), Expect = 1.447e-92
Identity = 136/283 (48.06%), Postives = 189/283 (66.78%), Query Frame = 1 
Query:   52 FVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            FVP C     E +++F +FI+   KL+V+TGAG+STESGIPDYRS+ VGLYA    RP+++  FLRS   RQRYWARN+ GWP FSS +PN AH  +  WE+  K+ + V+QNVD+LH K+G ++L ELHG  H+V+C++C     R  LQ+ F  LNP + +E     +APDGD  + D+ +R+F+ P C +C G LKPD++FFGD V     + V   +  +D LL +G+SL+VYS +R V  A +  IPI I+NIG+TR+DDLA  +L    G +LP +D
Sbjct:   48 FVPPCPPLSPEKVREFQRFITLSKKLLVMTGAGISTESGIPDYRSEKVGLYARNARRPIQHSDFLRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWERLGKLHWLVTQNVDSLHTKAGSQRLTELHGCMHRVLCLSCGAQTPRGALQQRFQVLNPTWGAEA--QGLAPDGDVFLSDEQVRTFQVPSCLRCGGPLKPDVVFFGDTVDPAKVDFVHKRVKEADALLVVGSSLQVYSGYRFVLTARDQKIPIAILNIGRTRSDDLACLKLSSRCGELLPLID 328
[Close]
BLAST of NAD-dependent protein deacylase vs. TrEMBL
Match: G1N9J9 (NAD-dependent protein deacylase OS=Meleagris gallopavo OX=9103 GN=SIRT4 PE=3 SV=2)

HSP 1 Score: 290.041 bits (741), Expect = 2.822e-92
Identity = 137/282 (48.58%), Postives = 184/282 (65.25%), Query Frame = 1 
Query:   46 MKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            + FVP C  P    +++  +FISS  KL V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+RS   RQRYWARN+ GWP FSS +PN AH V+ +WEK  K+ + V+QNVD LH K+G +++ ELHG TH+V C+ C    SR  LQE F  LNP++++E     +APDGD  + D+ +R F+ P C KC GILKPD+ FFGD V     + V   +  SD +L  G+S++VYS +R    A E  +PI ++NIG TR D  AS +L    G +LP
Sbjct:   12 LAFVPACLPPHPAEVEEMQRFISSSKKLFVMTGAGISTESGIPDYRSEGVGLYARSDRRPIQHTEFVRSASARQRYWARNFVGWPQFSSHQPNTAHLVLRQWEKLGKLHWLVTQNVDALHTKAGSQRMTELHGCTHRVFCLTCGDQTSRSALQEHFEALNPSWKAEA--LGVAPDGDVFLTDEQVRHFQVPACRKCGGILKPDVTFFGDTVSREKVDFVHQRLAESDSMLVAGSSMQVYSGYRFALAAKEKQLPIAVLNIGPTRLDHFASLKLNSRCGELLP 291
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt4 (sirtuin 4 [Source:NCBI gene;Acc:103041182])

HSP 1 Score: 278.1 bits (710), Expect = 7.835e-91
Identity = 131/284 (46.13%), Postives = 177/284 (62.32%), Query Frame = 1 
Query:   49 KFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            +FVP  +      ++    F+S   +L V+TGAG+STESGIPDYRS+ VGLYA    RP+++  F+ S + RQRYWARNY GWP FSS  PN AH  +  WE++ K+ + V+QNVD LH K+G + L ELHG +H+V+C+ C    +R ELQ  F  LNP +  E     +APDGD ++ED+ +  F+ P C  C GILKP + FFGD V   T E V   +   D L+  G+SL+VYS +R +  A E  IP+ I+NIG TRAD LA  ++    G VL  L+
Sbjct:   28 RFVPASSSVNKSTLEQLQTFVSQASRLFVMTGAGLSTESGIPDYRSEGVGLYARTDRRPLQHSEFVHSAKARQRYWARNYVGWPQFSSHLPNSAHYALRDWERKGKVHWLVTQNVDALHSKAGHQGLTELHGCSHRVVCLGCGQLTAREELQNRFAALNPGW--EASAGAVAPDGDVLLEDEQVLHFRVPACQACGGILKPQVTFFGDTVARATVEFVHNKLAECDALIVAGSSLQVYSGYRFLLAAKERQIPVAILNIGPTRADHLAQLKVSARCGEVLSSLN 309
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: ENSAMXT00000009390.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [Source:NCBI gene;Acc:111194338])

HSP 1 Score: 105.531 bits (262), Expect = 2.794e-25
Identity = 74/277 (26.71%), Postives = 127/277 (45.85%), Query Frame = 1 
Query:   76 LTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINC-DFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            LT ++ +F +  S    + ++TGAGVS ESG+P +R+        KT      Q F R   N  R W   ++   L     P+ AH  I + E    K+ +    ++QNVD LH+++G K ++E+HG+  +  C++C D   S H      + + P    + D     PD +       +++    D   C G+L+P +I+FG+ + +     V+  +   D  L +GT+  V+ +     Q     +P+   NI + RA+    Y  +G     LP
Sbjct:   26 LTRYMAEFREVFSKAKHIAIITGAGVSAESGLPTFRAASGHWRKWKTQDLATAQAFSR---NPSRVWEFYHYWRELALKATPSEAHRAIAECEARLSKQGRSVVVITQNVDELHRRAGSKHVLEVHGSLFRTRCLSCGDVDASHH------SPICPALEGKGD-----PDPNCRDAAIPVKNLPRCDEGGCDGLLRPHVIWFGETLDSHILTKVEKELDACDLCLLVGTASVVFPAAMFAPQVASRGVPVAEFNI-RPRAN---MYHFQGPCATTLP 284
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: ENSAMXT00000052214.1 (NAD-dependent protein deacylase sirtuin-5, mitochondrial-like [Source:NCBI gene;Acc:111194338])

HSP 1 Score: 101.679 bits (252), Expect = 8.717e-24
Identity = 70/273 (25.64%), Postives = 121/273 (44.32%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINC-DFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            + +F +  S    + ++TGAGVS ESG+P +R+        KT      Q F R   N  R W   ++   L     P+ AH  I + E    K+ +    ++QNVD LH+++G K ++E+HG+  +  C++C D   S H      + + P    + D     PD +       +++    D   C G+L+P +I+FG+ + +     V+  +   D  L +GT+  V+ +     Q     +P+   NI         +Y  +G     LP
Sbjct:   37 MAEFREVFSKAKHIAIITGAGVSAESGLPTFRAASGHWRKWKTQDLATAQAFSR---NPSRVWEFYHYWRELALKATPSEAHRAIAECEARLSKQGRSVVVITQNVDELHRRAGSKHVLEVHGSLFRTRCLSCGDVDASHH------SPICPALEGKGD-----PDPNCRDAAIPVKNLPRCDEGGCDGLLRPHVIWFGETLDSHILTKVEKELDACDLCLLVGTASVVFPAAMFAPQVASRGVPVAEFNIRPRANMSRFTYHFQGPCATTLP 295
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:103031700])

HSP 1 Score: 98.2117 bits (243), Expect = 1.295e-22
Identity = 75/283 (26.50%), Postives = 128/283 (45.23%), Query Frame = 1 
Query:   76 LTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLY-----ASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            LT+  +DFAK       + ++TGAGVS ESG+P +R    G Y     A   + P  +        +    W   ++   + SS  PN AH  I + E    ++ +    ++QN+D LH ++G + ++ELHG+  +  C++C    + H      + + P       + K APD +   ++  I     P C +  C G+L+P +++FG+ + +     V+  +   D  L +GTS  VY +     Q     +P+   N   T A     Y  +G  G +LP
Sbjct:   35 LTQFRKDFAK----AKHIAIITGAGVSAESGVPTFRG--AGGYWRKWQAQDLATPGAFS------RDPSLVWEFYHYRREVMSSKEPNAAHMSIAECEARLSQQGRSVVVITQNIDELHYRAGSRNILELHGSLFKTRCMSCGEVKANHT-----SPICPAL-----EGKGAPDPE--AKEARIPVNDLPRCERRGCHGLLRPYVVWFGEALDSDILSSVEEELEKCDLCLVVGTSSIVYPAAMFAPQVAARGVPVAEFNTESTPATMRFMYHFEGPCGTILP 293
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Match: sirt3 (sirtuin 3 [Source:NCBI gene;Acc:103044645])

HSP 1 Score: 94.3597 bits (233), Expect = 6.064e-21
Identity = 81/298 (27.18%), Postives = 134/298 (44.97%), Query Frame = 1 
Query:   88 IQDFAKFISSR--GKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRS----HENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGL--KQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIP--------IGIINIGKTRADDLASY--------RLKGSLGYVLPKLDEII 909
            ++D AK I  R   +++V+ GAG+ST SGIPD+RS   GLY +     + Y   +      H N + ++A     +P   + +PN+ H  I     + ++    +QN+D L + +G+  K L+E HG      C  C       EL           R++I    +                  P+C  CKG++KPDI+FFG+ +P     L  T    +D ++ +GTSLEV   F  +  A   ++         +G    G  R +D+A          RL  +LG+ +P+L+ ++
Sbjct:   77 LEDIAKGIRDREYKRIVVMAGAGISTPSGIPDFRSPGSGLYDNLQQYNLPYAEAIFEINYFHHNPKPFFALAKELYP--GNYQPNLTHYFIRLLHDKGQLLRMYTQNIDGLERMAGIPPKMLVEAHGTFATATCTVCRRDYKGEEL-----------RNDIMAGTV------------------PNCPHCKGVIKPDIVFFGEELPQ-HFFLYLTDFPIADLVIVMGTSLEV-EPFASLAGAVRGSVSRLLINRDLVGPFAWGSPRHNDVAELGDVVSGVRRLAEALGW-MPELEALM 340
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt4 (sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65])

HSP 1 Score: 280.796 bits (717), Expect = 1.249e-92
Identity = 130/282 (46.10%), Postives = 187/282 (66.31%), Query Frame = 1 
Query:   46 MKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            + FVP CA   T+       F+++  +L V+ GAG+STESGIPDYRS+ VGLYA  + RPM++  F RS   R+RYWARN+ GWP FSS RPN AH  + +WE++ ++ + V+QNVD LH K+G +++ ELHG +H+V+C++C     R ELQ+   ++NP ++ + +Q  IAPDGD ++ D  + SF+ P C  C G LKP++ FFGDNV   T + V   +  SD +L  G+SL+VYS +R ++ A+E  IPI I+NIG TRAD LA  ++    G +LP
Sbjct:   26 LAFVPACAPAGTQQRGQLQDFLANSRRLFVLAGAGLSTESGIPDYRSEGVGLYARTSRRPMQHAEFARSAVARRRYWARNFTGWPRFSSRRPNAAHLALGRWEQQGRLHWLVTQNVDALHAKAGSRRITELHGCSHRVVCLDCKEVTQRTELQQRMLDMNPGWQQQHEQ-AIAPDGDVLLSDSQVESFRVPPCRSCGGPLKPEVTFFGDNVDRRTVDDVYQRLE-SDTVLVAGSSLQVYSGYRFIRAAYEEKIPIAILNIGPTRADALAQLKVSSRCGDILP 305
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt2 (sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) [Source:NCBI gene;Acc:322309])

HSP 1 Score: 90.8929 bits (224), Expect = 1.907e-20
Identity = 70/246 (28.46%), Postives = 117/246 (47.56%), Query Frame = 1 
Query:  127 LIVVTGAGVSTESGIPDYRSKDVGLYAS--KTSRPMEYQVFLRSH--ENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADD 846
            ++ + GAG+ST +GIPD+RS   GLY +  K + P    VF   +  EN + ++A     +P     +P ++H  I   + +  +    +QN+D L + +GL+  +L+E HG  H   C+ C     RHE    +       + +I  +K+                  P C KCK ++KPDI+FFG+ +P      VQ+     D L+ +GTSL V     +  +  + + P  +IN+ K+   D
Sbjct:   44 IVCMVGAGISTAAGIPDFRSPGTGLYDNLQKYNLPHPQAVFDIGYFRENPEPFFALAKELYP--GQFKPTVSHYFIRLLKDKECLLRCYTQNIDTLERVAGLENNELVEAHGTFHTSHCLGC-----RHEYCLSW------MKEQIFSDKV------------------PRCEKCKSVVKPDIVFFGEALPEKFFTCVQSDFPKCDLLIIMGTSLVVQPFASLTSRVPD-STPRLLINLEKSGQCD 257
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Match: sirt3 (sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762])

HSP 1 Score: 78.5666 bits (192), Expect = 1.299e-16
Identity = 72/270 (26.67%), Postives = 111/270 (41.11%), Query Frame = 1 
Query:   82 EHIQDFAKFISSR--GKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRY--------WARNYFGW---PLFS--------SIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIIN 822
            E ++D A+ I       ++++ GAG+ST SGIPD+R+   GLY                 +N QRY        +  ++F     P F+        + RPN AH       +   +    +QN+D L + +GL    L+E HG      C  C                           K  P GD +   + + S K P C  C  ++KPDI+FFG+++P       Q     +D L+ +GTSLEV   F  +  A    +P  ++N
Sbjct:   12 ETLEDVARLIRDGHCKNIVLMAGAGMSTASGIPDFRTPGTGLY-----------------DNLQRYHLPFPEAVFDLDFFAVDPKPFFTLAQELYPGNCRPNDAHYFARLLHERRLLLRLYTQNIDGLERVAGLPPDMLVEAHGTFASATCTQC--------------------------RKPQP-GDQV--RRTVMSGKIPHCGACSAVVKPDIVFFGEDLPRRFYAYDQDF-SMADLLIVIGTSLEVM-PFAGLVSAVRPGVPRLLLN 233
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST1 (NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and meiotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance; HST1 has a paralog, SIR2, that arose from the whole genome duplication [Source:SGD;Acc:S000005429])

HSP 1 Score: 85.1149 bits (209), Expect = 2.744e-18
Identity = 72/264 (27.27%), Postives = 124/264 (46.97%), Query Frame = 1 
Query:   70 LPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPME-------YQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISRHELQEIFTELN----PNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIIN 822
            LP    I  F   + +  K++V+TGAGVST  GIPD+RS + G Y+      +E         +FL   ++   ++   +   P  +   P   H  I   + + K+    +QN+DNL   +G+   +L++ HG+     C+ C + I   ++ E    L     P    +  Q     +G+  ++  +  +F  P   K  G+LKPD+ FFG+ +P+   + ++  I   D L+C+GTSL+V     IV      ++P  +IN
Sbjct:  184 LPNFNTIDHFTATLRNAKKILVLTGAGVSTSLGIPDFRSSE-GFYSKIRHLGLEDPQDVFNLDIFL---QDPSVFYNIAHMVLPPENMYSP--LHSFIKMLQDKGKLLRNYTQNIDNLESYAGIDPDKLVQCHGSFATASCVTCHWQIPGEKIFENIRNLELPLCPYCYQKRKQYFPMSNGNNTVQTNI--NFNSP-ILKSYGVLKPDMTFFGEALPSRFHKTIRKDILECDLLICIGTSLKVAPVSEIVNMVPS-HVPQILIN 437
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: SIR2 (Conserved NAD+ dependent histone deacetylase of the Sirtuin family; deacetylation targets are primarily nuclear proteins; required for telomere hypercluster formation in quiescent yeast cells; involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and rDNA; negatively regulates initiation of DNA replication; functions as regulator of autophagy like mammalian homolog SIRT1, and also of mitophagy [Source:SGD;Acc:S000002200])

HSP 1 Score: 80.8777 bits (198), Expect = 6.650e-17
Identity = 71/267 (26.59%), Postives = 124/267 (46.44%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPME-------YQVFLRSHENRQRYWARNYFGWP--LFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISR----HELQEIFTELNP-------NFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIIN 822
            I  F + + +  K++V+TGAGVST  GIPD+RS + G Y+      ++       Y +F+  H+    Y   N    P  ++S +     H  I   + + K+    +QN+DNL   +G+   +L++ HG+     C+ C + +      ++++ +   L P        +  E   NK+      +   +   S + P      G+LKPDI FFG+ +P    + ++  I   D L+C+GTSL+V     IV      ++P  +IN
Sbjct:  244 IDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSE-GFYSKIKHLGLDDPQDVFNYNIFM--HDPSVFYNIANMVLPPEKIYSPL-----HSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKLVQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVG-----VAASQGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVSEIVNMVPS-HVPQVLIN 496
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST3 (Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000005551])

HSP 1 Score: 66.6254 bits (161), Expect = 1.749e-12
Identity = 71/273 (26.01%), Postives = 127/273 (46.52%), Query Frame = 1 
Query:   82 EHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLY-----------ASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSI---RPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK------------------QLIELHGNTHQVICINC--DFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPA---ITKELVQTLIH-TSDGLLCLGTSLEVYSSFRIVKQ 786
            E ++   K +S   ++  +TGAG+S  +GIPD+RS D GLY           + K+ R M + + L   + +   +A+  F   L+S++   +P   H+ I   +  +K+    +QN+D L +  GL                    +++LHG+   + C  C   F  SR+  + +        R E+    + PD + +I  +L    +        GIL+P+I+ +G+N P+   IT+ L   +I    D L+ +GTSL+V    ++VK+
Sbjct:   40 EVLRRVTKQLSRSRRIACLTGAGISCNAGIPDFRSSD-GLYDLVKKDCSQYWSIKSGREM-FDISLFRDDFKISIFAK--FMERLYSNVQLAKPTKTHKFIAHLKDRNKLLRCYTQNIDGLEESIGLTLSNRKLPLTSFSSHWKNLDVVQLHGDLKTLSCTKCFQTFPWSRYWSRCL-------RRGEL---PLCPDCEALINKRLNEGKRT--LGSNVGILRPNIVLYGENHPSCEIITQGLNLDIIKGNPDFLIIMGTSLKVDGVKQLVKK 296
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Match: HST2 (Cytoplasmic NAD(+)-dependent protein deacetylase; deacetylation targets are primarily cytoplasmic proteins; member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro; contains a nuclear export signal (NES); function regulated by its nuclear export [Source:SGD;Acc:S000005936])

HSP 1 Score: 65.0846 bits (157), Expect = 4.897e-12
Identity = 60/235 (25.53%), Postives = 102/235 (43.40%), Query Frame = 1 
Query:  121 GKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQV------FLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQ--LIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAI-------TKELVQTLIHTSDG------LLCLGTSLEVY 762
             K+I + GAG+ST  GIPD+RS   GLY +     + Y        F +S        A+  +      + RP+  H ++  ++ +  +    +QN+D L +++G+K   +IE HG+     CI C                   F+S++ ++ I    DF+             C  C  ++KP I+FFG+++P           E ++  I TS        ++ +GTSL VY
Sbjct:   25 AKVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYP----GNFRPSKFHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIGCGKVYPPQ-----------VFKSKLAEHPIK---DFV------------KCDVCGELVKPAIVFFGEDLPDSFSETWLNDSEWLREKITTSGKHPQQPLVIVVGTSLAVY 229
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO35866 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SK95])

HSP 1 Score: 273.092 bits (697), Expect = 3.945e-89
Identity = 133/266 (50.00%), Postives = 177/266 (66.54%), Query Frame = 1 
Query:  103 KFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLD 900
            +FI+   K+ V+TGAG+STESGI DYRS+  GLYA    RPMEYQVFL+S   RQRYWARNY GWP F S +PN AH  + K E    +   V+QNVD LH K+G K +IELHG +H+VIC+ C+   +R  LQ+   E NP++ + + Q + APDGD  +  + ++ FK P C  C GILKP+++FFGD+VP     +    +  SD L  +G+++EVYSS+R   +A +   PI I+NIGKTRAD LAS ++ G  G VLPKLD
Sbjct:   55 EFIAENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEYQVFLKSAVMRQRYWARNYVGWPEFGSRQPNEAHYALAKLETLGSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVICLGCNQITARTALQKRMIEFNPDWHA-VGQGQ-APDGDTFLTSEAVKDFKVPPCKACGGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILNIGKTRADKLASLKVSGVCGTVLPKLD 318
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO47362 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RMK8])

HSP 1 Score: 95.1301 bits (235), Expect = 2.823e-22
Identity = 70/278 (25.18%), Postives = 123/278 (44.24%), Query Frame = 1 
Query:  106 FISSRGKLIVVTGAGVSTESGIPDYRSKDVGLY----ASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEK----ESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDEII 909
             +S    ++ +TGAG+S ESGIP +R    GL+    A+  + P  +      H N    W    +   +  S +PN AH  I +++K    E K  + V+QN+D LHK +G + +IELHG   +  C +   T        I    +PN          APD    + +        P C +  C  +++P +++FG+ +  +  + ++ ++   D    +GTS  VY +        +  +P+   N+ +T      S+  +G  G  LP +  I+
Sbjct:   21 LLSKAKNILFLTGAGISAESGIPTFRGAG-GLWRTFSATDLATPGAF------HTNPSLVWEFYSYRREVVLSKKPNPAHFAIAEFQKKMRNEGKQVWVVTQNIDELHKTAGAEDVIELHGTLFKTRCNHV--TTQGSITLGIVLAPDPN----------APDAKIPLTEL-------PRCVRPECDALVRPHVVWFGEALDPVVLQQIEKVLGECDFCFIVGTSSVVYPAAGFAPMLAQRGVPVAEFNMEETSCTGQFSFHFQGKAGVTLPPILGIM 272
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO46813 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNW2])

HSP 1 Score: 94.3597 bits (233), Expect = 1.007e-21
Identity = 65/217 (29.95%), Postives = 106/217 (48.85%), Query Frame = 1 
Query:  127 LIVVTGAGVSTESGIPDYRSKDVGLYAS--KTSRPMEYQVFLRSH--ENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQ--LIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            +IV+TGAG+ST +GIPD+RS   GLY +  K + P    +F   +   N + ++A     +P   S +P ++H  I     +  +    +QNVD L + +G+    L+E HG+ H   CI C    ++ ++           R EI  +K+                  P C  C+G++KPDI+FFG+++P     LV   +   D ++ +GTSL V
Sbjct:   45 IIVMTGAGISTAAGIPDFRSPGTGLYDNLQKYNLPYPESIFEIGYFRSNPEPFFALCKELYP--GSFKPTMSHYFIKLLYDKKLLLRNYTQNVDTLERIAGVPDDLLVEAHGSFHTAHCIECKKEYTKEDV-----------RDEIFADKV------------------PRCSGCEGVIKPDIVFFGESLPGRFHRLVPQDMPHCDLIIIMGTSLAV 230
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO31684 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SX90])

HSP 1 Score: 87.4261 bits (215), Expect = 3.068e-19
Identity = 66/242 (27.27%), Postives = 111/242 (45.87%), Query Frame = 1 
Query:   70 LPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGW---PLF--------SSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQ-NKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            LP    + D  + I     +IV+TGAGVS   GIPD+RS+D G+YA  +   +EY        + Q  +   YF     P F           +P++ H  I + E+   +    SQN+D L + +G+ ++I+ HG+     C+ C   +    ++E        FR  I   +  +PD +F                    I+KPDI+FFG+++P+     +    + +D L+ +G+SL+V
Sbjct:   53 LPNVNTLDDVVRLIKKCKNIIVLTGAGVSVSCGIPDFRSRD-GIYAKLS---VEYPDL----PDPQAMFDITYFNQNPKPFFKFAKEIYPGQFKPSLCHRFIHQLEEHGHLLRNYSQNIDTLEQVAGITRVIQCHGSFSTASCMRCKHKVPCEAIKEDI------FRKNIPVCSTCSPDEEF------------------PSIMKPDIVFFGESLPSNFYTHLGDDSNKADLLIVIGSSLKV 262
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Match: EDO48459 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RIU3])

HSP 1 Score: 84.3445 bits (207), Expect = 1.996e-18
Identity = 69/235 (29.36%), Postives = 110/235 (46.81%), Query Frame = 1 
Query:   91 QDFAKFISSRGK---LIVVTGAGVSTESGIPDYRSKDVGL------YASKTSRPM-EYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            +  A++I+S GK   ++V+TGAG+ST +GIPD+R+   GL      Y   T+R + E   F     N + ++      +P     +P I+H  I   + +  +    +QN+D L + +G+    L+E HG+ H   C+ C+   S+  +           R EI  +KI                  P C +C G++KPDI FFGD +P    +L        D L+ +GTSL V
Sbjct:    7 EGIARYITS-GKCKNIVVLTGAGISTTAGIPDFRTPGSGLFNVLQTYGLTTARSIFEIDYF---QMNPKPFFVAAKAVYP--GQFKPTISHYFIKLLQNKGLLLRHYTQNIDTLERVAGITGDHLMEAHGSFHTGHCMACNKEYSQDWI-----------RVEIMADKI------------------PRCTECDGVVKPDIGFFGDPMPDKFYQLAAEDFPKCDLLIVMGTSLIV 206
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt4 (sirtuin 4 [Source:NCBI gene;Acc:101156953])

HSP 1 Score: 286.96 bits (733), Expect = 2.784e-94
Identity = 129/282 (45.74%), Postives = 186/282 (65.96%), Query Frame = 1 
Query:   43 QMKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVL 888
            Q+ FVP C       ++   +F++   +++V+TGAG+STESGIPDYRS+ VGLYA    RPM++  F+RS  +RQRYWARN+ GWP FSS +PN+AH  + +WE+  K+ + V+QNVD LH K+G K+L ELHG  H+V+C++C     R +LQ  F  +NP + ++     +APDGD  +ED+ + +F+ P C  C GILKP++ FFGD V   T E V   +  SD +L +G+SL+VYS +R +  A +  +P+ I+NIG TRAD LA  ++ G  G VL
Sbjct:   26 QLNFVPPCRTTDARSLELLQEFVTRARRMLVITGAGLSTESGIPDYRSEGVGLYARTDRRPMQHAEFVRSARSRQRYWARNFLGWPQFSSHQPNLAHRALRRWEEGGKLHWLVTQNVDALHGKAGQKRLTELHGCAHRVVCLSCSAVTPREDLQGRFVAINPEWSAQA--GAVAPDGDVFLEDEQVLNFRVPSCQNCGGILKPEVTFFGDTVSKTTVEFVHGRLAESDSVLVVGSSLQVYSGYRFLLAASDRKLPVAILNIGPTRADHLAKLKVSGRCGEVL 305
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:101162440])

HSP 1 Score: 106.301 bits (264), Expect = 1.584e-25
Identity = 71/278 (25.54%), Postives = 129/278 (46.40%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLY----ASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            +  F  F +    + ++TGAGVS ESG+P +R    G +    A   + P  +        N  R W   ++   +  +  PN AH+ I + E    K+ +    ++QN+D LH+++G K ++E+HG+  +  C++C    + H+     + + P  +     +K APD +    D  I   + P C +  C G+L+P +++FG+++ A        ++ + D  L +GTS  VY +     Q     +P+   N+  T A     +  +G  G  LP
Sbjct:   36 LAAFRDFFAKAENIAILTGAGVSAESGVPTFRGAG-GFWRKWQAQDLATPEAFS------GNPSRVWEFYHYRREVMLTKDPNAAHKAIAECEERLGKQGRKVTVITQNIDELHRRAGSKNILEIHGSLFKTRCLSCGHEEANHK-----SPICPALK-----DKGAPDPN--THDAQIPVEQLPRCERAGCGGLLRPAVVWFGESLDADVLSRSHEVLDSCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPATTHFKFHFQGPCGTTLP 294
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: ENSORLT00000021506.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial [Source:NCBI gene;Acc:101163111])

HSP 1 Score: 99.7525 bits (247), Expect = 4.021e-23
Identity = 70/279 (25.09%), Postives = 128/279 (45.88%), Query Frame = 1 
Query:   82 EHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            +++ +F    S    + ++TGAGVS ESG+P +R +        +      + F R   N  R W   ++   L    +P+  H  I + E    K+ +    ++Q +D+LH+++G K ++++HG+  +  C++C              ++  N RS I    + K AP  +  + D  I   K P C +  C G+L+P+++FFG+ + +     V+  I   D  L +GTS  VY +     +     +P+   N+  T   +  +Y  +G  G  LP
Sbjct:   33 QNMSEFRSVFSKAKHIAIITGAGVSAESGVPTFRGEHEKWRKWVSQDLATPEAFSR---NPSRVWEFYHYRRELVLDKKPSAVHVAIAECEARLKKQGRTVVVITQCIDDLHRQAGSKHVLKVHGSLMETRCMSCG-------------QVTVNKRSPICAALKGKGAPGLN--VADAQIPVDKLPRCEERDCHGLLRPNVVFFGETLDSHILTKVEKEIEICDLCLVVGTSSIVYPAAMFGPRVASRGVPVAEFNMSTTPKTEYFTYHFQGPCGTTLP 293
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: ENSORLT00000021505.2 (NAD-dependent protein deacylase sirtuin-5, mitochondrial [Source:NCBI gene;Acc:101163111])

HSP 1 Score: 98.9821 bits (245), Expect = 6.495e-23
Identity = 70/277 (25.27%), Postives = 126/277 (45.49%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEID---QNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLP 891
            + +F    S    + ++TGAGVS ESG+P +R +        +      + F R   N  R W   ++   L    +P+  H  I + E    K+ +    ++Q +D+LH+++G K ++++HG+  +  C++C              ++  N RS I    + K AP  +  + D  I   K P C +  C G+L+P+++FFG+ + +     V+  I   D  L +GTS  VY +     +     +P+   N+  T   +  +Y  +G  G  LP
Sbjct:   35 MSEFRSVFSKAKHIAIITGAGVSAESGVPTFRGEHEKWRKWVSQDLATPEAFSR---NPSRVWEFYHYRRELVLDKKPSAVHVAIAECEARLKKQGRTVVVITQCIDDLHRQAGSKHVLKVHGSLMETRCMSCG-------------QVTVNKRSPICAALKGKGAPGLN--VADAQIPVDKLPRCEERDCHGLLRPNVVFFGETLDSHILTKVEKEIEICDLCLVVGTSSIVYPAAMFGPRVASRGVPVAEFNMSTTPKTEYFTYHFQGPCGTTLP 293
[Close]
BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Match: sirt5 (sirtuin 5 [Source:NCBI gene;Acc:101162440])

HSP 1 Score: 99.3673 bits (246), Expect = 7.626e-23
Identity = 67/261 (25.67%), Postives = 123/261 (47.13%), Query Frame = 1 
Query:   88 IQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLY----ASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFK--CKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRA 840
            +  F  F +    + ++TGAGVS ESG+P +R    G +    A   + P  +        N  R W   ++   +  +  PN AH+ I + E    K+ +    ++QN+D LH+++G K ++E+HG+  +  C++C    + H+     + + P  +     +K APD +    D  I   + P C +  C G+L+P +++FG+++ A        ++ + D  L +GTS  VY +     Q     +P+   N+  T A
Sbjct:   36 LAAFRDFFAKAENIAILTGAGVSAESGVPTFRGAG-GFWRKWQAQDLATPEAFS------GNPSRVWEFYHYRREVMLTKDPNAAHKAIAECEERLGKQGRKVTVITQNIDELHRRAGSKNILEIHGSLFKTRCLSCGHEEANHK-----SPICPALK-----DKGAPDPN--THDAQIPVEQLPRCERAGCGGLLRPAVVWFGESLDADVLSRSHEVLDSCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNMENTPA 277
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000074693.1 (SMESG000074693.1)

HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0
Identity = 286/288 (99.31%), Postives = 288/288 (100.00%), Query Frame = 1 
Query:   46 MKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDEII 909
            MKFVPFCALPLTEHIQDFAKFISSRGKL+VVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQL+ELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDEII
Sbjct:    1 MKFVPFCALPLTEHIQDFAKFISSRGKLLVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLVELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDEII 288
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000027361.1 (SMESG000027361.1)

HSP 1 Score: 105.145 bits (261), Expect = 1.480e-25
Identity = 74/275 (26.91%), Postives = 127/275 (46.18%), Query Frame = 1 
Query:   94 DFAKFISSRGKLIVVTGAGVSTESGIPDYR-SKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVICKWE----KESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDE 903
            +F + +     ++V+TGAG+S +SGIP +R S+ +     ++        FL   EN    W   +F   +     PN AH  + K+E    KE+K F  ++QNVD LH+++G + +I +HG   +  C+ C     ++  +   + +    R + D N  + +   I E+ L      P C  C+G+L+P++++FG+N+   T E     I   D  + +GTS  V        Q     +P+   N+  T       Y ++G     LP L E
Sbjct:    5 EFKQTLKLAKNILVITGAGISADSGIPTFRGSRALRWRNYESCNLATLPAFL---ENPSLVWEFYHFRREICLKANPNAAHAALSKFEMKCKKENKQFTLITQNVDGLHRRAGSENIISIHGEIFETKCMKC-----KNVKENFISPICEGLRDKGDPN--STENSSIPEESL------PTCEFCRGLLRPNVVWFGENLHPDTLEKSYDAIKNCDLCVVIGTSGIVQPVASFPYQVINRGVPVAEFNVESTDISGQVQYFIRGPASSTLPPLLE 263
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079803.1 (SMESG000079803.1)

HSP 1 Score: 90.8929 bits (224), Expect = 1.864e-19
Identity = 74/252 (29.37%), Postives = 118/252 (46.83%), Query Frame = 1 
Query:  103 KFISSRGK-LIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEY-------QVFLRSHENRQRYWARNYFGWPLFSS--IRPNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLK--QLIELHGNTHQVICINCDFTISRHELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHELNIPIGIIN 822
            K ++S+ K ++++ GAG+S  SGIPD+RS   GLY +     + Y         FL   +N + ++A       LF S   RPN  H      +++  +    +QN+D L + +GL    L+E HG      C+ C    S  +L+E            ID+++I                    C KC+GI+KPDI+FFG+++P+    L ++    +D LL +GTSLEV   F  +  +     P  +IN
Sbjct:  149 KILTSKIKNIVIMAGAGISCPSGIPDFRSPGTGLYDNLKQYKIPYPEAIFDIDYFL---QNPKPFFA---LAKELFPSGKYRPNKVHYFFRLLQEKKLLRRVYTQNIDGLERLAGLNDTNLVEAHGTFASASCVRCGEDYSATQLKE-----------SIDKSEIC------------------YCSKCRGIVKPDIVFFGEDLPS-KFHLFRSDFQQADLLLVMGTSLEV-EPFASIVDSTRFGTPRVLIN 363
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 75.0998 bits (183), Expect = 2.327e-14
Identity = 61/245 (24.90%), Postives = 113/245 (46.12%), Query Frame = 1 
Query:   82 EHIQDFAK---FISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGW---PLFSSIR--------PNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQ-EIFTE---LNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCK-GILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            E+I  F +    I     ++V+TGAG+S   G+PD+RS++ G+YA          V     +  Q  +  +YF     P F   +        P+  H  I   E + K+    SQN+D L + +G+K +I  HG+     C+ C++ +    ++ ++  +   + P+  +E ++N          ++ L+ S  + D       I+KPD++FFG+ +P      +       D L+ +G+SL+V
Sbjct:   82 EYINTFKQACDLIRVSKNIMVLTGAGISVPCGVPDFRSRN-GIYA-------RLAVDFPDLDEPQSMFDIHYFSKNPKPFFKFAKEIYPGKFTPSFGHRFIKVLEDKGKLLRNYSQNIDTLEQIAGIKNIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERN----------QENLLSSIGNSDEVDTNIPIMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKV 308
[Close]
BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Match: SMESG000079103.1 (SMESG000079103.1)

HSP 1 Score: 75.0998 bits (183), Expect = 2.588e-14
Identity = 61/245 (24.90%), Postives = 113/245 (46.12%), Query Frame = 1 
Query:   82 EHIQDFAK---FISSRGKLIVVTGAGVSTESGIPDYRSKDVGLYASKTSRPMEYQVFLRSHENRQRYWARNYFGW---PLFSSIR--------PNIAHEVICKWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRHELQ-EIFTE---LNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCK-GILKPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEV 759
            E+I  F +    I     ++V+TGAG+S   G+PD+RS++ G+YA          V     +  Q  +  +YF     P F   +        P+  H  I   E + K+    SQN+D L + +G+K +I  HG+     C+ C++ +    ++ ++  +   + P+  +E ++N          ++ L+ S  + D       I+KPD++FFG+ +P      +       D L+ +G+SL+V
Sbjct:   91 EYINTFKQACDLIRVSKNIMVLTGAGISVPCGVPDFRSRN-GIYA-------RLAVDFPDLDEPQSMFDIHYFSKNPKPFFKFAKEIYPGKFTPSFGHRFIKVLEDKGKLLRNYSQNIDTLEQIAGIKNIIHCHGSFASATCMRCEYKVKGEFIESDVMNQQIPICPSCTTEDERN----------QENLLSSIGNSDEVDTNIPIMKPDVVFFGEGLPKDFHAKLSEDKDQVDLLIVIGSSLKV 317
The following BLAST results are available for this feature:
BLAST of NAD-dependent protein deacylase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SIRT41.185e-8946.64sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932][more]
SIRT45.614e-4059.22sirtuin 4 [Source:HGNC Symbol;Acc:HGNC:14932][more]
SIRT52.669e-3029.39sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT51.241e-2729.26sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
SIRT55.057e-2728.10sirtuin 5 [Source:HGNC Symbol;Acc:HGNC:14933][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sir-2.22.297e-8042.96NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.22.152e-7842.66NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.22.190e-7842.66NAD-dependent protein deacylase sir-2.2 [Source:U... [more]
sir-2.31.402e-7539.79NAD-dependent protein deacylase sir-2.3 [Source:U... [more]
sir-2.15.394e-2026.67NAD-dependent protein deacetylase sir-2.1 [Source... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sirt42.660e-8444.21gene:FBgn0029783 transcript:FBtr0070852[more]
Sirt45.513e-6445.21gene:FBgn0029783 transcript:FBtr0070851[more]
Sirt45.513e-6445.21gene:FBgn0029783 transcript:FBtr0070850[more]
Sirt24.520e-2031.19gene:FBgn0038788 transcript:FBtr0083882[more]
Sirt24.520e-2031.19gene:FBgn0038788 transcript:FBtr0344243[more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt41.989e-9146.64sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt41.989e-9146.64sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt41.989e-9146.64sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt43.029e-7946.59sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt51.011e-2025.18sirtuin 5 [Source:NCBI gene;Acc:436878][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt42.278e-9046.29sirtuin 4 [Source:NCBI gene;Acc:733911][more]
lin28a1.134e-2525.71lin-28 homolog A [Source:Xenbase;Acc:XB-GENE-49138... [more]
tspear1.791e-2027.80thrombospondin-type laminin G domain and EAR repea... [more]
tspear1.826e-2027.80thrombospondin-type laminin G domain and EAR repea... [more]
tspear2.324e-2027.80thrombospondin-type laminin G domain and EAR repea... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sirt45.680e-9248.06sirtuin 4 [Source:MGI Symbol;Acc:MGI:1922637][more]
Sirt45.680e-9248.06sirtuin 4 [Source:MGI Symbol;Acc:MGI:1922637][more]
Sirt51.683e-2728.37sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt51.683e-2728.37sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
Sirt56.897e-2528.57sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596][more]
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BLAST of NAD-dependent protein deacylase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8R216|SIR4_MOUSE3.973e-9148.06NAD-dependent protein lipoamidase sirtuin-4, mitoc... [more]
sp|Q1JQC6|SIR4_BOVIN3.979e-8946.64NAD-dependent protein lipoamidase sirtuin-4, mitoc... [more]
sp|Q9Y6E7|SIR4_HUMAN5.689e-8946.64NAD-dependent protein lipoamidase sirtuin-4, mitoc... [more]
sp|Q8IRR5|SIR4_DROME2.666e-8344.21NAD-dependent protein deacylase Sirt4 OS=Drosophil... [more]
sp|Q20480|SIR41_CAEEL2.922e-7942.96NAD-dependent protein deacylase sir-2.2 OS=Caenorh... [more]
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BLAST of NAD-dependent protein deacylase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
E2ADS21.545e-9450.53NAD-dependent deacetylase sirtuin-4 OS=Camponotus ... [more]
A0A3B4A6T57.670e-9448.40NAD-dependent protein deacylase OS=Periophthalmus ... [more]
G5B7809.493e-9348.06NAD-dependent ADP-ribosyltransferase sirtuin-4 (Fr... [more]
A0A0P6JFX21.447e-9248.06NAD-dependent protein lipoamidase sirtuin-4, mitoc... [more]
G1N9J92.822e-9248.58NAD-dependent protein deacylase OS=Meleagris gallo... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt47.835e-9146.13sirtuin 4 [Source:NCBI gene;Acc:103041182][more]
ENSAMXT00000009390.22.794e-2526.71NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
ENSAMXT00000052214.18.717e-2425.64NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sirt51.295e-2226.50sirtuin 5 [Source:NCBI gene;Acc:103031700][more]
sirt36.064e-2127.18sirtuin 3 [Source:NCBI gene;Acc:103044645][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 3
Match NameE-valueIdentityDescription
sirt41.249e-9246.10sirtuin 4 [Source:ZFIN;Acc:ZDB-GENE-041010-65][more]
sirt21.907e-2028.46sirtuin 2 (silent mating type information regulati... [more]
sirt31.299e-1626.67sirtuin 3 [Source:ZFIN;Acc:ZDB-GENE-070112-1762][more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 4
Match NameE-valueIdentityDescription
HST12.744e-1827.27NAD(+)-dependent histone deacetylase; essential su... [more]
SIR26.650e-1726.59Conserved NAD+ dependent histone deacetylase of th... [more]
HST31.749e-1226.01Member of the Sir2 family of NAD(+)-dependent prot... [more]
HST24.897e-1225.53Cytoplasmic NAD(+)-dependent protein deacetylase; ... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO358663.945e-8950.00Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO473622.823e-2225.18Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO468131.007e-2129.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO316843.068e-1927.27Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO484591.996e-1829.36Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of NAD-dependent protein deacylase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sirt42.784e-9445.74sirtuin 4 [Source:NCBI gene;Acc:101156953][more]
sirt51.584e-2525.54sirtuin 5 [Source:NCBI gene;Acc:101162440][more]
ENSORLT00000021506.24.021e-2325.09NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
ENSORLT00000021505.26.495e-2325.27NAD-dependent protein deacylase sirtuin-5, mitocho... [more]
sirt57.626e-2325.67sirtuin 5 [Source:NCBI gene;Acc:101162440][more]
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BLAST of NAD-dependent protein deacylase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000074693.10.000e+099.31SMESG000074693.1[more]
SMESG000027361.11.480e-2526.91SMESG000027361.1[more]
SMESG000079803.11.864e-1929.37SMESG000079803.1[more]
SMESG000079103.12.327e-1424.90SMESG000079103.1[more]
SMESG000079103.12.588e-1424.90SMESG000079103.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30019307 ID=SMED30019307|Name=NAD-dependent protein deacylase|organism=Schmidtea mediterranea sexual|type=transcript|length=1287bp
TACAATAACCTTGAATTTTTATTTAAAATGTCAATCTGATAACAAATGAA
ATTTGTTCCATTCTGTGCATTACCTCTTACTGAACATATCCAAGATTTTG
CTAAATTCATTTCATCCCGTGGAAAATTAATAGTTGTAACAGGAGCTGGA
GTTTCTACAGAAAGTGGAATACCTGATTATAGATCTAAAGATGTTGGATT
ATATGCCAGCAAAACATCAAGACCTATGGAATATCAAGTATTTCTAAGAA
GTCATGAAAATCGACAACGATATTGGGCTCGCAATTATTTTGGATGGCCA
TTATTTTCGTCTATTAGACCTAATATAGCTCACGAAGTAATATGTAAATG
GGAAAAAGAGTCAAAAATATTTTACACCGTAAGTCAAAATGTTGATAATC
TTCATAAAAAGTCTGGATTGAAGCAACTCATAGAACTCCATGGAAATACG
CACCAAGTGATCTGTATAAATTGTGATTTTACAATATCCCGTCATGAATT
GCAGGAAATTTTTACGGAATTAAATCCAAATTTTAGATCTGAAATTGATC
AAAATAAAATTGCCCCAGATGGAGATTTTATAATTGAAGATAAATTAATT
CGCTCATTTAAACATCCAGATTGTTTCAAATGTAAAGGTATTCTTAAGCC
TGACATAATATTTTTCGGAGATAATGTTCCTGCTATTACAAAGGAATTAG
TACAAACTTTAATTCATACAAGTGATGGTCTGTTGTGTTTGGGAACATCA
TTGGAGGTATATTCGAGTTTCAGAATTGTTAAACAAGCTCATGAATTAAA
CATACCGATTGGTATTATCAATATCGGTAAAACAAGAGCTGATGATCTCG
CTTCGTATCGACTGAAAGGCTCATTGGGTTACGTTCTGCCCAAACTAGAT
GAAATTATTTAGAAATTAAATTGTAATTTATATTATAGCTCAGAGATAAT
TTGATAAAATTCACAAATATTTTTATGTTTATTTTACAACCGAGAATCAC
TCTTGACTTGCAGACCATCACTCGATAATTAATCGTTTAACGACGTGTTT
AAGTTTTTTTTTGTATTCTCTTCACAGTTTCTAGTAAAGTCTCGTAGCAA
ATTTGATAATTAAAGAATTGAATTCAGTTTAATTCAATCTGAGGTTATTT
ATAGTTTCACTAGGAGCATGTCTTGGCTCTGACTTTTCGTGTTCGTTATA
AAATTATTGGAGTTGTTTAACAAAATGGAAATTCATAAAAAAAATTATAT
TTTTCGTCGGAGGTGTGGTAACCAAGGCCGAATTGAA
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protein sequence of SMED30019307-orf-1

>SMED30019307-orf-1 ID=SMED30019307-orf-1|Name=SMED30019307-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=289bp
MKFVPFCALPLTEHIQDFAKFISSRGKLIVVTGAGVSTESGIPDYRSKDV
GLYASKTSRPMEYQVFLRSHENRQRYWARNYFGWPLFSSIRPNIAHEVIC
KWEKESKIFYTVSQNVDNLHKKSGLKQLIELHGNTHQVICINCDFTISRH
ELQEIFTELNPNFRSEIDQNKIAPDGDFIIEDKLIRSFKHPDCFKCKGIL
KPDIIFFGDNVPAITKELVQTLIHTSDGLLCLGTSLEVYSSFRIVKQAHE
LNIPIGIINIGKTRADDLASYRLKGSLGYVLPKLDEII*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000017photoreceptor neuron
PLANA:0002032epidermal cell
PLANA:0002056medial muscle cell
Vocabulary: INTERPRO
TermDefinition
IPR026591Sirtuin_cat_small_dom_sf
IPR003000Sirtuin
IPR029035DHS-like_NAD/FAD-binding_dom
IPR026590Ssirtuin_cat_dom
Vocabulary: molecular function
TermDefinition
GO:0070403NAD+ binding
GO:0008270zinc ion binding
GO:0016740transferase activity
GO:0016787hydrolase activity
GO:0034979NAD-dependent protein deacetylase activity
GO:0046872metal ion binding
Vocabulary: cellular component
TermDefinition
GO:0005739mitochondrion
GO:0005759mitochondrial matrix
Vocabulary: biological process
TermDefinition
GO:0006471protein ADP-ribosylation
GO:0006476protein deacetylation
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableGENE3DG3DSA:3.40.50.1220coord: 22..278
e-value: 2.2E-69
score: 235.4
NoneNo IPR availablePANTHERPTHR43688FAMILY NOT NAMEDcoord: 2..286
IPR003000Sirtuin familyPFAMPF02146SIR2coord: 33..240
e-value: 2.0E-48
score: 164.6
IPR026591Sirtuin, catalytic core small domain superfamilyGENE3DG3DSA:3.30.1600.10coord: 42..209
e-value: 2.2E-69
score: 235.4
IPR026590Sirtuin family, catalytic core domainPROSITEPS50305SIRTUINcoord: 16..288
score: 41.766
IPR029035DHS-like NAD/FAD-binding domain superfamilySUPERFAMILYSSF52467DHS-like NAD/FAD-binding domaincoord: 11..288