Pleckstrin domain-containing family G member

Overview
NamePleckstrin domain-containing family G member
Smed IDSMED30019301
Length (bp)1887
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Pleckstrin domain-containing family G member (SMED30019301) t-SNE clustered cells

Violin plots show distribution of expression levels for Pleckstrin domain-containing family G member (SMED30019301) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Pleckstrin domain-containing family G member (SMED30019301) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Pleckstrin domain-containing family G member (SMED30019301) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30019301

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 3

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30019301SMESG000010407.1 dd_Smed_v4_10288_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30019301SMESG000010407.1 Contig53861newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30019301SMESG000010407.1 Contig53861uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Match: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6 [Source:HGNC Symbol;Acc:HGNC:25562])

HSP 1 Score: 83.9593 bits (206), Expect = 2.790e-33
Identity = 42/160 (26.25%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE   +    I+ ++     + LQ +   L  +    LFGN+  L ++H   W+  +   L ++R   +PLD   ++ GFL+    F  Y  +     Q     +EQ++T+     +++W +++ R+ R
Sbjct:  141 IEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQ-RVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

HSP 2 Score: 79.337 bits (194), Expect = 2.790e-33
Identity = 60/210 (28.57%), Postives = 103/210 (49.05%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKARTGF 1588
             P QRITKY +LL  +   S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L   ++    Y ++            R F   D+T  +        R L+  G +++   +   +DV  FLF+D+ LV K  +K  +K ++ + P+ L+KL+ +  ++ NSF+ I L +F  + S ++V   +  +   W++K  +A+   
Sbjct:  308 KPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLAAAAQRIGPY-EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA-DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAAL 511
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Match: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6 [Source:HGNC Symbol;Acc:HGNC:25562])

HSP 1 Score: 83.9593 bits (206), Expect = 2.790e-33
Identity = 42/160 (26.25%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE   +    I+ ++     + LQ +   L  +    LFGN+  L ++H   W+  +   L ++R   +PLD   ++ GFL+    F  Y  +     Q     +EQ++T+     +++W +++ R+ R
Sbjct:  141 IEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQ-RVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

HSP 2 Score: 79.337 bits (194), Expect = 2.790e-33
Identity = 60/210 (28.57%), Postives = 103/210 (49.05%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKARTGF 1588
             P QRITKY +LL  +   S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L   ++    Y ++            R F   D+T  +        R L+  G +++   +   +DV  FLF+D+ LV K  +K  +K ++ + P+ L+KL+ +  ++ NSF+ I L +F  + S ++V   +  +   W++K  +A+   
Sbjct:  308 KPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLAAAAQRIGPY-EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA-DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAAL 511
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Match: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6 [Source:HGNC Symbol;Acc:HGNC:25562])

HSP 1 Score: 83.9593 bits (206), Expect = 3.320e-33
Identity = 42/160 (26.25%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE   +    I+ ++     + LQ +   L  +    LFGN+  L ++H   W+  +   L ++R   +PLD   ++ GFL+    F  Y  +     Q     +EQ++T+     +++W +++ R+ R
Sbjct:  109 IEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQ-RVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 267

HSP 2 Score: 78.9518 bits (193), Expect = 3.320e-33
Identity = 60/210 (28.57%), Postives = 103/210 (49.05%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKARTGF 1588
             P QRITKY +LL  +   S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L   ++    Y ++            R F   D+T  +        R L+  G +++   +   +DV  FLF+D+ LV K  +K  +K ++ + P+ L+KL+ +  ++ NSF+ I L +F  + S ++V   +  +   W++K  +A+   
Sbjct:  276 KPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLAAAAQRIGPY-EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA-DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAAL 479
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Match: PLEKHG6 (pleckstrin homology and RhoGEF domain containing G6 [Source:HGNC Symbol;Acc:HGNC:25562])

HSP 1 Score: 84.3445 bits (207), Expect = 4.015e-29
Identity = 42/160 (26.25%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE   +    I+ ++     + LQ +   L  +    LFGN+  L ++H   W+  +   L ++R   +PLD   ++ GFL+    F  Y  +     Q     +EQ++T+     +++W +++ R+ R
Sbjct:  141 IEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQ-RVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

HSP 2 Score: 65.0846 bits (157), Expect = 4.015e-29
Identity = 50/169 (29.59%), Postives = 82/169 (48.52%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENS 1471
             P QRITKY +LL  +   S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L   ++    Y ++            R F   D+T  +        R L+  G +++   +   +DV  FLF+D+ LV K  +K  +K ++ + P+ L+KL+ +  ++ S
Sbjct:  308 KPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLAAAAQRIGPY-EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA-DKAKVIRPPLMLEKLVCQPLRDPS 470
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:HGNC Symbol;Acc:HGNC:29105])

HSP 1 Score: 75.485 bits (184), Expect = 1.410e-28
Identity = 58/210 (27.62%), Postives = 102/210 (48.57%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDE-KQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  +   + E   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   +  + + P+ +DK++ +  ++  SF+ I LN+F +  G      +   + + W+D  YN
Sbjct:  560 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACM----RQRQERQRLAAV----VSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYN 760

HSP 2 Score: 72.0182 bits (175), Expect = 1.410e-28
Identity = 51/174 (29.31%), Postives = 87/174 (50.00%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW +++ G E  T+ +C +Q A+WEL+ TEAS +    ++I +FL   + LQ    E   LC+ E   LF NI ++ Q H  LW   ++  L K+R     L      +GF    S+F+ Y  +   +    + ++   + +   R YI W +++ +  R  +   +AKP
Sbjct:  394 RLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 563
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Match: rhgf-2 (RHo Guanine nucleotide exchange Factor [Source:UniProtKB/TrEMBL;Acc:Q22354])

HSP 1 Score: 65.4698 bits (158), Expect = 7.183e-22
Identity = 53/202 (26.24%), Postives = 95/202 (47.03%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRV--KCDYVDIFHVIGRQFIVFDITKSLKDF---------PDRVLIHAGHLKLYLDKNKT-MDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKS-GKENSFIAIVLNDFMTLSGIMVLIGTSDEVKL-WMD 1561
            P QR+T+Y +LL  + K  ++E+E+    EM   + D  E   + +  E    +++  L +  R     DYVD   +   +     +  +L DF           R LI+ G L++   K  +  DV C +F D+FL+C++ +  +++L+I K P+ + K++      +N F  + L DF T   +  +  +  E  L W D
Sbjct:  279 PMQRLTRYNLLLKAVLKVTTDENER----EMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDEL--ERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTSGPEDTLRWTD 474

HSP 2 Score: 58.151 bits (139), Expect = 7.183e-22
Identity = 43/166 (25.90%), Postives = 79/166 (47.59%), Query Frame = 1 
Query:  490 WRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLP---VFITLQNQYDELFPLCKSELFGNIEQLYQSHLE-LWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +++E  W +IV   E+ +     +Q AIWE++ TE     F +I +  +L     ++T       L  +    +F N   L+  + + LW ++I   L KSR   EPLD++ ++ GF  I +    Y +F        K +Q++ K S   R+++ W +  +  +R
Sbjct:  109 YKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTE-----FRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFVTWAEAQENLDR 269
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Match: rhgf-2 (RHo Guanine nucleotide exchange Factor [Source:UniProtKB/TrEMBL;Acc:Q22354])

HSP 1 Score: 65.0846 bits (157), Expect = 7.713e-22
Identity = 53/202 (26.24%), Postives = 95/202 (47.03%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRV--KCDYVDIFHVIGRQFIVFDITKSLKDF---------PDRVLIHAGHLKLYLDKNKT-MDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKS-GKENSFIAIVLNDFMTLSGIMVLIGTSDEVKL-WMD 1561
            P QR+T+Y +LL  + K  ++E+E+    EM   + D  E   + +  E    +++  L +  R     DYVD   +   +     +  +L DF           R LI+ G L++   K  +  DV C +F D+FL+C++ +  +++L+I K P+ + K++      +N F  + L DF T   +  +  +  E  L W D
Sbjct:  424 PMQRLTRYNLLLKAVLKVTTDENER----EMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDEL--ERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTSGPEDTLRWTD 619

HSP 2 Score: 58.5362 bits (140), Expect = 7.713e-22
Identity = 43/166 (25.90%), Postives = 79/166 (47.59%), Query Frame = 1 
Query:  490 WRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLP---VFITLQNQYDELFPLCKSELFGNIEQLYQSHLE-LWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +++E  W +IV   E+ +     +Q AIWE++ TE     F +I +  +L     ++T       L  +    +F N   L+  + + LW ++I   L KSR   EPLD++ ++ GF  I +    Y +F        K +Q++ K S   R+++ W +  +  +R
Sbjct:  254 YKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTE-----FRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFVTWAEAQENLDR 414
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Match: rhgf-2 (RHo Guanine nucleotide exchange Factor [Source:UniProtKB/TrEMBL;Acc:Q22354])

HSP 1 Score: 65.0846 bits (157), Expect = 7.713e-22
Identity = 53/202 (26.24%), Postives = 95/202 (47.03%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRV--KCDYVDIFHVIGRQFIVFDITKSLKDF---------PDRVLIHAGHLKLYLDKNKT-MDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKS-GKENSFIAIVLNDFMTLSGIMVLIGTSDEVKL-WMD 1561
            P QR+T+Y +LL  + K  ++E+E+    EM   + D  E   + +  E    +++  L +  R     DYVD   +   +     +  +L DF           R LI+ G L++   K  +  DV C +F D+FL+C++ +  +++L+I K P+ + K++      +N F  + L DF T   +  +  +  E  L W D
Sbjct:  424 PMQRLTRYNLLLKAVLKVTTDENER----EMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDEL--ERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTSGPEDTLRWTD 619

HSP 2 Score: 58.5362 bits (140), Expect = 7.713e-22
Identity = 43/166 (25.90%), Postives = 79/166 (47.59%), Query Frame = 1 
Query:  490 WRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLP---VFITLQNQYDELFPLCKSELFGNIEQLYQSHLE-LWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +++E  W +IV   E+ +     +Q AIWE++ TE     F +I +  +L     ++T       L  +    +F N   L+  + + LW ++I   L KSR   EPLD++ ++ GF  I +    Y +F        K +Q++ K S   R+++ W +  +  +R
Sbjct:  254 YKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTE-----FRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFVTWAEAQENLDR 414
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Match: rhgf-2 (RHo Guanine nucleotide exchange Factor [Source:UniProtKB/TrEMBL;Acc:Q22354])

HSP 1 Score: 65.4698 bits (158), Expect = 8.355e-22
Identity = 53/202 (26.24%), Postives = 95/202 (47.03%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRV--KCDYVDIFHVIGRQFIVFDITKSLKDF---------PDRVLIHAGHLKLYLDKNKT-MDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKS-GKENSFIAIVLNDFMTLSGIMVLIGTSDEVKL-WMD 1561
            P QR+T+Y +LL  + K  ++E+E+    EM   + D  E   + +  E    +++  L +  R     DYVD   +   +     +  +L DF           R LI+ G L++   K  +  DV C +F D+FL+C++ +  +++L+I K P+ + K++      +N F  + L DF T   +  +  +  E  L W D
Sbjct:  566 PMQRLTRYNLLLKAVLKVTTDENER----EMISNLVDCAESATAQLNKELNNNDLRAMLGDVMRTIEGPDYVDQDEL--ERLFNLKLPLNLGDFMPLLHPRKPTHRTLIYRGDLRMQEGKKGSKADVHCIIFTDMFLICRKVQGKKDRLKILKPPIHMGKMMFHYFADQNGFYLVHLTDFHTAQALYSMHTSGPEDTLRWTD 761

HSP 2 Score: 57.7658 bits (138), Expect = 8.355e-22
Identity = 43/166 (25.90%), Postives = 79/166 (47.59%), Query Frame = 1 
Query:  490 WRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLP---VFITLQNQYDELFPLCKSELFGNIEQLYQSHLE-LWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +++E  W +IV   E+ +     +Q AIWE++ TE     F +I +  +L     ++T       L  +    +F N   L+  + + LW ++I   L KSR   EPLD++ ++ GF  I +    Y +F        K +Q++ K S   R+++ W +  +  +R
Sbjct:  396 YKLEKDWREIVHNHESLSDKSIKQQEAIWEIVTTE-----FRYIKLLRYLSNLSFYLTDLQNCGFLKDIENRLVFFNFVTLFNVNYDSLWLQSIEPILAKSRETGEPLDVNYLQNGFRDIENWSRCYTNFHLAHSDSLKHIQKKLKESENFRDFVTWAEAQENLDR 556
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Match: prhg-1 (pep chromosome:WBcel235:I:912415:926562:-1 gene:WBGene00022391.1 transcript:Y95B8A.12e.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:prhg-1)

HSP 1 Score: 60.4622 bits (145), Expect = 2.675e-9
Identity = 61/228 (26.75%), Postives = 106/228 (46.49%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQD-----LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLV-------ETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLE-------------IFKSPVRLDKLLVKSGKEN----------SFIAIVLNDFMTLSGIMVLIGTSDEVK-LWMDKYNKA 1576
            P QRIT+  ILL  I   S E+E +      +D MT+++    + +  +   E RL++++ ++V       E      D++ +   + RQF      ++L   P R LIH G L+L ++  +T+D+  FLFND+F++ K  KK  +KL+             + + PV LD  +      N          +F+ I L  +  + GI  L       K LW++K+ ++
Sbjct:  328 PLQRITRLPILLREIHKRSEEEESKGKVEKVIDTMTESLRSIDDSVQWLHNFE-RLQQLQTQVVWPNISDLEPKSYVPDFLRV--ALSRQF-----CENLLAHPRRKLIHEGPLEL-VENGRTVDMYAFLFNDMFVLTKT-KKCASKLKVKGVPIGKSEHYIVQRQPVPLDSCVFCDADSNDQATPMSLKFAFVIIHLTRYYQVVGIYTLQAADKADKELWIEKFQES 545
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Match: CG42674 (gene:FBgn0261556 transcript:FBtr0302714)

HSP 1 Score: 79.337 bits (194), Expect = 2.127e-30
Identity = 61/206 (29.61%), Postives = 98/206 (47.57%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKD-FSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFI-----VFDITKSLKDFPDRVLIHAGHLKL-----YLDKNKTMDVECFLFNDLFLVCKQ-HKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKART 1582
            P QR+TKY +LL  IK   S+ +E + +D M  +V +F+  +N+ +T  +  E +K  +V       D VD  + +  + I     +FD+   ++  P     H  HL +     + D     DV CFL  DL LVCK   K+    L++ + P   D+L+V+    N+   + LN+F   +    L  T  E K W D   +A+T
Sbjct: 1171 PMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESY--DVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP---AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT--EAKNWYDALWRAKT 1369

HSP 2 Score: 73.559 bits (179), Expect = 2.127e-30
Identity = 45/173 (26.01%), Postives = 82/173 (47.40%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKPISK 1011
            +  SW D V   ++ ++SE   Q AIWEL+ TE   ++    V ++FL     +Q +   L  + ++ LF N+  + +++++ W   +   +  S I +EPL  +  +EGFLS +SIF  Y  +   Q       +E    +     Y+ W +     NR  +  I  +P+ +
Sbjct: 1004 MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEE-GLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQR 1174
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Match: CG42674 (gene:FBgn0261556 transcript:FBtr0302712)

HSP 1 Score: 79.337 bits (194), Expect = 2.428e-30
Identity = 61/206 (29.61%), Postives = 98/206 (47.57%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKD-FSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFI-----VFDITKSLKDFPDRVLIHAGHLKL-----YLDKNKTMDVECFLFNDLFLVCKQ-HKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKART 1582
            P QR+TKY +LL  IK   S+ +E + +D M  +V +F+  +N+ +T  +  E +K  +V       D VD  + +  + I     +FD+   ++  P     H  HL +     + D     DV CFL  DL LVCK   K+    L++ + P   D+L+V+    N+   + LN+F   +    L  T  E K W D   +A+T
Sbjct: 1171 PMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESY--DVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP---AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT--EAKNWYDALWRAKT 1369

HSP 2 Score: 73.1738 bits (178), Expect = 2.428e-30
Identity = 45/173 (26.01%), Postives = 82/173 (47.40%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKPISK 1011
            +  SW D V   ++ ++SE   Q AIWEL+ TE   ++    V ++FL     +Q +   L  + ++ LF N+  + +++++ W   +   +  S I +EPL  +  +EGFLS +SIF  Y  +   Q       +E    +     Y+ W +     NR  +  I  +P+ +
Sbjct: 1004 MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEE-GLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQR 1174
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Match: CG42674 (gene:FBgn0261556 transcript:FBtr0332699)

HSP 1 Score: 79.7221 bits (195), Expect = 4.894e-30
Identity = 61/206 (29.61%), Postives = 98/206 (47.57%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIK-DFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFH-----VIGRQFIVFDITKSLKDFPDRVLIHAGHLKL-----YLDKNKTMDVECFLFNDLFLVCKQ-HKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKART 1582
            P QR+TKY +LL  IK   S+ +E + +D M  +V +F+  +N+ +T  +  E +K  +V       D VD  +     +I +   +FD+   ++  P     H  HL +     + D     DV CFL  DL LVCK   K+    L++ + P   D+L+V+    N+   + LN+F   +    L  T  E K W D   +A+T
Sbjct:  393 PMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMVRIESY--DVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP---AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT--EAKNWYDALWRAKT 591

HSP 2 Score: 72.0182 bits (175), Expect = 4.894e-30
Identity = 45/173 (26.01%), Postives = 82/173 (47.40%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKPISK 1011
            +  SW D V   ++ ++SE   Q AIWEL+ TE   ++    V ++FL     +Q +   L  + ++ LF N+  + +++++ W   +   +  S I +EPL  +  +EGFLS +SIF  Y  +   Q       +E    +     Y+ W +     NR  +  I  +P+ +
Sbjct:  226 MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEE-GLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQR 396
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Match: CG42674 (gene:FBgn0261556 transcript:FBtr0332698)

HSP 1 Score: 79.337 bits (194), Expect = 1.455e-29
Identity = 62/207 (29.95%), Postives = 101/207 (48.79%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKD-FSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-DYVDIFH-----VIGRQFIVFDITKSLKDFPDRVLIHAGHLKL-----YLDKNKTMDVECFLFNDLFLVCKQ-HKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKART 1582
            P QR+TKY +LL  IK   S+ +E + +D M  +V +F+  +N+ +T  +  E +K  +V   R++  D VD  +     +I +   +FD+   ++  P     H  HL +     + D     DV CFL  DL LVCK   K+    L++ + P   D+L+V+    N+   + LN+F   +    L  T  E K W D   +A+T
Sbjct:  957 PMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMV---RIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP---AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT--EAKNWYDALWRAKT 1155

HSP 2 Score: 70.8626 bits (172), Expect = 1.455e-29
Identity = 45/173 (26.01%), Postives = 82/173 (47.40%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKPISK 1011
            +  SW D V   ++ ++SE   Q AIWEL+ TE   ++    V ++FL     +Q +   L  + ++ LF N+  + +++++ W   +   +  S I +EPL  +  +EGFLS +SIF  Y  +   Q       +E    +     Y+ W +     NR  +  I  +P+ +
Sbjct:  790 MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEE-GLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQR 960
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Match: CG42674 (gene:FBgn0261556 transcript:FBtr0302716)

HSP 1 Score: 79.337 bits (194), Expect = 1.455e-29
Identity = 62/207 (29.95%), Postives = 101/207 (48.79%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKD-FSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-DYVDIFH-----VIGRQFIVFDITKSLKDFPDRVLIHAGHLKL-----YLDKNKTMDVECFLFNDLFLVCKQ-HKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKART 1582
            P QR+TKY +LL  IK   S+ +E + +D M  +V +F+  +N+ +T  +  E +K  +V   R++  D VD  +     +I +   +FD+   ++  P     H  HL +     + D     DV CFL  DL LVCK   K+    L++ + P   D+L+V+    N+   + LN+F   +    L  T  E K W D   +A+T
Sbjct:  957 PMQRLTKYSLLLAAIKKHMSDVEEIEAIDVMMHSVENFVGSVNNHLTMRQENERLKGVMV---RIESYDVVDTNNEVLDKMIKQNSQMFDLCAPMRGCP---AYHVRHLFMEGDHKFKDNLGKSDVHCFLLTDLLLVCKTIAKRGLGALKVIRQPYLTDQLIVQLAPNNTLNCVYLNEFQVATTAFTLQCT--EAKNWYDALWRAKT 1155

HSP 2 Score: 70.8626 bits (172), Expect = 1.455e-29
Identity = 45/173 (26.01%), Postives = 82/173 (47.40%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKPISK 1011
            +  SW D V   ++ ++SE   Q AIWEL+ TE   ++    V ++FL     +Q +   L  + ++ LF N+  + +++++ W   +   +  S I +EPL  +  +EGFLS +SIF  Y  +   Q       +E    +     Y+ W +     NR  +  I  +P+ +
Sbjct:  790 MHKSWRDFV-NSDSMSESEVKIQTAIWELVTTEVYYIHALQTVTDLFLACLEAVQEE-GLLIDVDQARLFSNVRAVCEANIKFWTLWLYPMVAHSAITHEPLRCAFFQEGFLSFASIFAPYKIYCAEQSTCQFYCKELNHNNALFTSYLAWCESQKMCNRLRLADIVVRPMQR 960
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Match: plekhg5b (pleckstrin homology domain containing, family G (with RhoGef domain) member 5b [Source:ZFIN;Acc:ZDB-GENE-090908-6])

HSP 1 Score: 69.707 bits (169), Expect = 5.307e-24
Identity = 47/178 (26.40%), Postives = 84/178 (47.19%), Query Frame = 1 
Query:  487 NWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMRE----------YIKWTKEYDRTNRFGI 984
            N  +E SW  ++   E+ ++ +  +Q AIWELI TEA+ +    ++ ++FL   + LQ+     E+ P   + LF NI+ + + H  LW + +   L K+R     ++ + ++EGF + +S F+ Y  +            E+E    YMR           YI W +   + NR  +
Sbjct:  396 NLTLEDSWRTLLDDPESLSRRQFQQQEAIWELIQTEATYIKKLRVITDLFLCGLLNLQDNSLLGEVEP---TRLFSNIQDIVRLHCTLWVQVMFPALEKARGSRSLIEPTDLQEGFSTFASRFQPYIRY----------CMEEESCMEYMRSLLRDNELFKIYITWAETNKQCNRLKL 560

HSP 2 Score: 62.003 bits (149), Expect = 5.307e-24
Identity = 54/205 (26.34%), Postives = 99/205 (48.29%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDF-------------PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMT-LSGIMVLIGTSDEVKLWMD 1561
            P QR+TKY +LL  I K   ++  +  L+ M   V  F+  ++S    + R  + +++L  TS      V+ +  +  +    ++ K+LK+F             P+  R L   G L++   K+  MD  CFLF DL L+ K  K+   K+++ + P+ L  ++ +  K+  SF+ I LN+F + ++       ++ + K W D
Sbjct:  567 PHQRLTKYPLLLKTILKKTEDQASRDALNNMVACVEGFINGVDS----QMRQRQEQQKLAATS----ARVESYEAV--EGASEEVEKALKEFSRIDLTAPMIGTSPEETRQLHLEGALRMKEGKDSRMDAYCFLFTDLLLITKPVKR-LEKVKVVRQPLLLHNVVCRELKDPGSFVLIYLNEFKSAVAAYTFQANSAAQGKSWTD 760
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Match: plekhg5a (pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [Source:ZFIN;Acc:ZDB-GENE-060503-766])

HSP 1 Score: 67.781 bits (164), Expect = 8.686e-24
Identity = 43/169 (25.44%), Postives = 80/169 (47.34%), Query Frame = 1 
Query:  505 SWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            SW  ++   E  T+ +C +Q AIWEL+ TE+  +    ++ ++FL   + LQ      E+ P   + LF NI+ + Q H  LW   +   L K+R     L+ + + +GF +    F+ Y  +   +    + ++   K +   R Y+ W + + + NR  +   + KP
Sbjct:  419 SWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQESGLLTEVEP---TRLFSNIQDIVQLHSSLWTEVMLPALEKARQKRTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKP 584

HSP 2 Score: 62.7734 bits (151), Expect = 8.686e-24
Identity = 48/177 (27.12%), Postives = 91/177 (51.41%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTG---EKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF 1498
            L  P QR+TKY +LL  + K   +   ++ ++ M  AV  F+  ++S +     +++L  I  R+     V+    ++  ++ +++  FD+   +   P    R L+  G LK+   K   MDV CFLF D+ L+ K  K+   K+++ + P+ +  ++ +  K+  SF+ I LN+F
Sbjct:  581 LVKPHQRLTKYPLLLKSVLKKTDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERIL-KEYNNFDLMAPVMGAPPEETRQLLLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKR-VEKVKVIRQPLVIHNVVCRELKDPGSFLLIYLNEF 755
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Match: plekhg5a (pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [Source:ZFIN;Acc:ZDB-GENE-060503-766])

HSP 1 Score: 67.781 bits (164), Expect = 8.760e-24
Identity = 43/169 (25.44%), Postives = 80/169 (47.34%), Query Frame = 1 
Query:  505 SWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            SW  ++   E  T+ +C +Q AIWEL+ TE+  +    ++ ++FL   + LQ      E+ P   + LF NI+ + Q H  LW   +   L K+R     L+ + + +GF +    F+ Y  +   +    + ++   K +   R Y+ W + + + NR  +   + KP
Sbjct:  397 SWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQESGLLTEVEP---TRLFSNIQDIVQLHSSLWTEVMLPALEKARQKRTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKP 562

HSP 2 Score: 62.7734 bits (151), Expect = 8.760e-24
Identity = 47/174 (27.01%), Postives = 90/174 (51.72%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTG---EKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF 1498
            P QR+TKY +LL  + K   +   ++ ++ M  AV  F+  ++S +     +++L  I  R+     V+    ++  ++ +++  FD+   +   P    R L+  G LK+   K   MDV CFLF D+ L+ K  K+   K+++ + P+ +  ++ +  K+  SF+ I LN+F
Sbjct:  562 PHQRLTKYPLLLKSVLKKTDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERIL-KEYNNFDLMAPVMGAPPEETRQLLLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKR-VEKVKVIRQPLVIHNVVCRELKDPGSFLLIYLNEF 733
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Match: plekhg5a (pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [Source:ZFIN;Acc:ZDB-GENE-060503-766])

HSP 1 Score: 68.1662 bits (165), Expect = 9.057e-24
Identity = 43/169 (25.44%), Postives = 80/169 (47.34%), Query Frame = 1 
Query:  505 SWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            SW  ++   E  T+ +C +Q AIWEL+ TE+  +    ++ ++FL   + LQ      E+ P   + LF NI+ + Q H  LW   +   L K+R     L+ + + +GF +    F+ Y  +   +    + ++   K +   R Y+ W + + + NR  +   + KP
Sbjct:  367 SWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQESGLLTEVEP---TRLFSNIQDIVQLHSSLWTEVMLPALEKARQKRTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKP 532

HSP 2 Score: 62.7734 bits (151), Expect = 9.057e-24
Identity = 48/177 (27.12%), Postives = 91/177 (51.41%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTG---EKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF 1498
            L  P QR+TKY +LL  + K   +   ++ ++ M  AV  F+  ++S +     +++L  I  R+     V+    ++  ++ +++  FD+   +   P    R L+  G LK+   K   MDV CFLF D+ L+ K  K+   K+++ + P+ +  ++ +  K+  SF+ I LN+F
Sbjct:  529 LVKPHQRLTKYPLLLKSVLKKTDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERIL-KEYNNFDLMAPVMGAPPEETRQLLLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKR-VEKVKVIRQPLVIHNVVCRELKDPGSFLLIYLNEF 703
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Match: plekhg5a (pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [Source:ZFIN;Acc:ZDB-GENE-060503-766])

HSP 1 Score: 67.781 bits (164), Expect = 1.025e-23
Identity = 43/169 (25.44%), Postives = 80/169 (47.34%), Query Frame = 1 
Query:  505 SWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            SW  ++   E  T+ +C +Q AIWEL+ TE+  +    ++ ++FL   + LQ      E+ P   + LF NI+ + Q H  LW   +   L K+R     L+ + + +GF +    F+ Y  +   +    + ++   K +   R Y+ W + + + NR  +   + KP
Sbjct:  319 SWKQLLENPEILTRRQCHQQEAIWELLQTESDYIKKLHVITDLFLCGLLNLQESGLLTEVEP---TRLFSNIQDIVQLHSSLWTEVMLPALEKARQKRTMLNPTELHQGFSTFGFRFKPYIRYCMEEEGCMEYMRTLLKDNELFRIYVTWAETHKQCNRLKLTDMLVKP 484

HSP 2 Score: 62.7734 bits (151), Expect = 1.025e-23
Identity = 48/177 (27.12%), Postives = 91/177 (51.41%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTG---EKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF 1498
            L  P QR+TKY +LL  + K   +   ++ ++ M  AV  F+  ++S +     +++L  I  R+     V+    ++  ++ +++  FD+   +   P    R L+  G LK+   K   MDV CFLF D+ L+ K  K+   K+++ + P+ +  ++ +  K+  SF+ I LN+F
Sbjct:  481 LVKPHQRLTKYPLLLKSVLKKTDDPPTREAINRMVAAVECFINSVDSQMRHREEKQKLAAIAGRIEAYEAVEGASEEVERIL-KEYNNFDLMAPVMGAPPEETRQLLLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKR-VEKVKVIRQPLVIHNVVCRELKDPGSFLLIYLNEF 655
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:100496612])

HSP 1 Score: 68.9366 bits (167), Expect = 4.286e-24
Identity = 61/207 (29.47%), Postives = 102/207 (49.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKR---LEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSL-KDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDKYNKAR 1579
            L  P QR+TKY +LL  I K   +   ++ +  M  +V  F+ H+NS +   +    L  I  R+   E      D VD    I ++F   D+T  +    P+  R L+  G LK+   K+  MDV CFLF DLFL+ K  KK   + ++ + P+ +DK++ +  K+  SF+ I LN+F +         +   + + W++ +  A+
Sbjct:  500 LVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVD---KILKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK-AERTKVIRQPLLVDKIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQ 702

HSP 2 Score: 63.5438 bits (153), Expect = 4.286e-24
Identity = 44/169 (26.04%), Postives = 85/169 (50.30%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLL-KSRIDNEPLDISVMKEGFL--SISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGI 984
            +E SW +I+   E  T+ +C +Q AIWEL+ TEA+ +    ++ ++FL   + LQ    E   LC+ E   LF NI+++ Q H       +  P+L K+R     L+    ++GF      S+F+ Y  +   +    + ++   + +   + Y+ W++++ + NR  +
Sbjct:  337 LEDSWQEIIEVPETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQ----ESGILCEVEPDKLFSNIQEIIQLH-----STVMVPILEKARKTKSLLNPMDFQKGFRFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKL 496
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:100496612])

HSP 1 Score: 69.3218 bits (168), Expect = 4.319e-24
Identity = 61/207 (29.47%), Postives = 102/207 (49.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKR---LEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSL-KDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDKYNKAR 1579
            L  P QR+TKY +LL  I K   +   ++ +  M  +V  F+ H+NS +   +    L  I  R+   E      D VD    I ++F   D+T  +    P+  R L+  G LK+   K+  MDV CFLF DLFL+ K  KK   + ++ + P+ +DK++ +  K+  SF+ I LN+F +         +   + + W++ +  A+
Sbjct:  495 LVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVD---KILKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK-AERTKVIRQPLLVDKIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQ 697

HSP 2 Score: 63.1586 bits (152), Expect = 4.319e-24
Identity = 44/169 (26.04%), Postives = 85/169 (50.30%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLL-KSRIDNEPLDISVMKEGFL--SISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGI 984
            +E SW +I+   E  T+ +C +Q AIWEL+ TEA+ +    ++ ++FL   + LQ    E   LC+ E   LF NI+++ Q H       +  P+L K+R     L+    ++GF      S+F+ Y  +   +    + ++   + +   + Y+ W++++ + NR  +
Sbjct:  332 LEDSWQEIIEVPETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQ----ESGILCEVEPDKLFSNIQEIIQLH-----STVMVPILEKARKTKSLLNPMDFQKGFRFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKL 491
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:100496612])

HSP 1 Score: 68.9366 bits (167), Expect = 4.430e-24
Identity = 61/207 (29.47%), Postives = 102/207 (49.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKR---LEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSL-KDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDKYNKAR 1579
            L  P QR+TKY +LL  I K   +   ++ +  M  +V  F+ H+NS +   +    L  I  R+   E      D VD    I ++F   D+T  +    P+  R L+  G LK+   K+  MDV CFLF DLFL+ K  KK   + ++ + P+ +DK++ +  K+  SF+ I LN+F +         +   + + W++ +  A+
Sbjct:  493 LVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVD---KILKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK-AERTKVIRQPLLVDKIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQ 695

HSP 2 Score: 63.5438 bits (153), Expect = 4.430e-24
Identity = 44/169 (26.04%), Postives = 85/169 (50.30%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLL-KSRIDNEPLDISVMKEGFL--SISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGI 984
            +E SW +I+   E  T+ +C +Q AIWEL+ TEA+ +    ++ ++FL   + LQ    E   LC+ E   LF NI+++ Q H       +  P+L K+R     L+    ++GF      S+F+ Y  +   +    + ++   + +   + Y+ W++++ + NR  +
Sbjct:  330 LEDSWQEIIEVPETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQ----ESGILCEVEPDKLFSNIQEIIQLH-----STVMVPILEKARKTKSLLNPMDFQKGFRFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKL 489
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:100496612])

HSP 1 Score: 68.9366 bits (167), Expect = 4.540e-24
Identity = 61/207 (29.47%), Postives = 102/207 (49.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKR---LEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSL-KDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDKYNKAR 1579
            L  P QR+TKY +LL  I K   +   ++ +  M  +V  F+ H+NS +   +    L  I  R+   E      D VD    I ++F   D+T  +    P+  R L+  G LK+   K+  MDV CFLF DLFL+ K  KK   + ++ + P+ +DK++ +  K+  SF+ I LN+F +         +   + + W++ +  A+
Sbjct:  505 LVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVD---KILKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK-AERTKVIRQPLLVDKIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQ 707

HSP 2 Score: 63.5438 bits (153), Expect = 4.540e-24
Identity = 44/169 (26.04%), Postives = 85/169 (50.30%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLL-KSRIDNEPLDISVMKEGFL--SISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGI 984
            +E SW +I+   E  T+ +C +Q AIWEL+ TEA+ +    ++ ++FL   + LQ    E   LC+ E   LF NI+++ Q H       +  P+L K+R     L+    ++GF      S+F+ Y  +   +    + ++   + +   + Y+ W++++ + NR  +
Sbjct:  342 LEDSWQEIIEVPETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQ----ESGILCEVEPDKLFSNIQEIIQLH-----STVMVPILEKARKTKSLLNPMDFQKGFRFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKL 501
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Match: PLEKHG5 (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:100496612])

HSP 1 Score: 68.9366 bits (167), Expect = 4.718e-24
Identity = 61/207 (29.47%), Postives = 102/207 (49.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKR---LEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSL-KDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDKYNKAR 1579
            L  P QR+TKY +LL  I K   +   ++ +  M  +V  F+ H+NS +   +    L  I  R+   E      D VD    I ++F   D+T  +    P+  R L+  G LK+   K+  MDV CFLF DLFL+ K  KK   + ++ + P+ +DK++ +  K+  SF+ I LN+F +         +   + + W++ +  A+
Sbjct:  516 LVKPHQRLTKYPLLLKSILKKTDDLQVRESIILMISSVERFINHVNSRMRQRQEQQRLAAIISRIDSYEAVDSSTDEVD---KILKEFCRLDLTAPMIGTSPEDTRQLLLEGSLKMKEGKDSKMDVYCFLFTDLFLITKPVKK-AERTKVIRQPLLVDKIVCRELKDPGSFLLIYLNEFRSAVAAYTFQASGQSLCRGWIEAFFNAQ 718

HSP 2 Score: 63.5438 bits (153), Expect = 4.718e-24
Identity = 44/169 (26.04%), Postives = 85/169 (50.30%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLL-KSRIDNEPLDISVMKEGFL--SISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGI 984
            +E SW +I+   E  T+ +C +Q AIWEL+ TEA+ +    ++ ++FL   + LQ    E   LC+ E   LF NI+++ Q H       +  P+L K+R     L+    ++GF      S+F+ Y  +   +    + ++   + +   + Y+ W++++ + NR  +
Sbjct:  353 LEDSWQEIIEVPETLTRRQCHQQEAIWELLHTEATYIKKLKVITDLFLCCLLNLQ----ESGILCEVEPDKLFSNIQEIIQLH-----STVMVPILEKARKTKSLLNPMDFQKGFRFKMFESLFKPYIRYCMEEEGCMEYMRNLHRDNELFKSYVTWSEKHKQCNRLKL 512
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Match: Plekhg6 (pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [Source:MGI Symbol;Acc:MGI:2682298])

HSP 1 Score: 85.8853 bits (211), Expect = 1.176e-34
Identity = 69/208 (33.17%), Postives = 107/208 (51.44%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDI-TKSLKDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCK-QHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKART 1582
            P QRITKY +LL  ++  S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L+  ++    Y ++            R F   D+ T  L   P+  R L+  G +++   +   MDV  FLF+D+ LV K Q K DR K  + + P+ L+KL+ +  ++ NSF+ I L +F  + S + V   +S E   W++K   A+T
Sbjct:  309 PHQRITKYPLLLQAVRKRSPEPRAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLMAVAQRIGPY-EVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLLEGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAK--VIRPPLMLEKLVCRPLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQT 509

HSP 2 Score: 81.2629 bits (199), Expect = 1.176e-34
Identity = 42/160 (26.25%), Postives = 78/160 (48.75%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +E SW ++V+  +   +  C +Q A+WEL+ TE   L    I+ ++     + LQ +   L  +    LFGN+  L ++H   WE  +   L  +R   +PLD   ++ GFL+    F+ Y  +     Q     +EQ+ T+     +++W +++ R+ R
Sbjct:  141 MEKSWKELVLEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQ-RVGLLTEVSAETLFGNVPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTFVQWCEKHKRSGR 299
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Match: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5 [Source:MGI Symbol;Acc:MGI:2652860])

HSP 1 Score: 76.2554 bits (186), Expect = 8.352e-27
Identity = 58/210 (27.62%), Postives = 104/210 (49.52%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  + +   +   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  538 LAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCM----RQRQERQRLAGV----VSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYN 738

HSP 2 Score: 64.6994 bits (156), Expect = 8.352e-27
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW ++  G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI ++ + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  372 RLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 541
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Match: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5 [Source:MGI Symbol;Acc:MGI:2652860])

HSP 1 Score: 75.8702 bits (185), Expect = 9.367e-27
Identity = 58/210 (27.62%), Postives = 104/210 (49.52%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  + +   +   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  581 LAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCM----RQRQERQRLAGV----VSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYN 781

HSP 2 Score: 64.6994 bits (156), Expect = 9.367e-27
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW ++  G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI ++ + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  415 RLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 584
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Match: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5 [Source:MGI Symbol;Acc:MGI:2652860])

HSP 1 Score: 76.2554 bits (186), Expect = 9.448e-27
Identity = 58/210 (27.62%), Postives = 104/210 (49.52%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  + +   +   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  551 LAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCM----RQRQERQRLAGV----VSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYN 751

HSP 2 Score: 64.6994 bits (156), Expect = 9.448e-27
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW ++  G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI ++ + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  385 RLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 554
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Match: Plekhg5 (pleckstrin homology domain containing, family G (with RhoGef domain) member 5 [Source:MGI Symbol;Acc:MGI:2652860])

HSP 1 Score: 76.2554 bits (186), Expect = 9.449e-27
Identity = 58/210 (27.62%), Postives = 104/210 (49.52%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  + +   +   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  551 LAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCM----RQRQERQRLAGV----VSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYN 751

HSP 2 Score: 64.6994 bits (156), Expect = 9.449e-27
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW ++  G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI ++ + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  385 RLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 554
[Close]
BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Match: sp|Q8R0J1|PKHG6_MOUSE (Pleckstrin homology domain-containing family G member 6 OS=Mus musculus OX=10090 GN=Plekhg6 PE=2 SV=2)

HSP 1 Score: 85.8853 bits (211), Expect = 7.126e-34
Identity = 69/208 (33.17%), Postives = 107/208 (51.44%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDI-TKSLKDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCK-QHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKART 1582
            P QRITKY +LL  ++  S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L+  ++    Y ++            R F   D+ T  L   P+  R L+  G +++   +   MDV  FLF+D+ LV K Q K DR K  + + P+ L+KL+ +  ++ NSF+ I L +F  + S + V   +S E   W++K   A+T
Sbjct:  309 PHQRITKYPLLLQAVRKRSPEPRAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLMAVAQRIGPY-EVLEPSSEEVEKNLRPFSTLDLMTPVLGVAPEYTRQLLLEGPVRVKEGREGKMDVYLFLFSDVLLVTKPQRKADRAK--VIRPPLMLEKLVCRPLRDPNSFLLIHLTEFQCVSSALTVHCPSSTERARWLEKTQHAQT 509

HSP 2 Score: 81.2629 bits (199), Expect = 7.126e-34
Identity = 42/160 (26.25%), Postives = 78/160 (48.75%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            +E SW ++V+  +   +  C +Q A+WEL+ TE   L    I+ ++     + LQ +   L  +    LFGN+  L ++H   WE  +   L  +R   +PLD   ++ GFL+    F+ Y  +     Q     +EQ+ T+     +++W +++ R+ R
Sbjct:  141 MEKSWKELVLEHKEMNRQLCHQQEALWELLTTELIYLRKLKIMTDLLAAGLLNLQ-RVGLLTEVSAETLFGNVPNLIRAHRRFWEEVLQPILEDTRTSGQPLDPVSLQNGFLTFGQRFQPYVQYCLRVKQTMAYAREQQDTNPLFHTFVQWCEKHKRSGR 299
[Close]
BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Match: sp|Q3KR16|PKHG6_HUMAN (Pleckstrin homology domain-containing family G member 6 OS=Homo sapiens OX=9606 GN=PLEKHG6 PE=1 SV=3)

HSP 1 Score: 83.9593 bits (206), Expect = 1.231e-32
Identity = 42/160 (26.25%), Postives = 80/160 (50.00%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE   +    I+ ++     + LQ +   L  +    LFGN+  L ++H   W+  +   L ++R   +PLD   ++ GFL+    F  Y  +     Q     +EQ++T+     +++W +++ R+ R
Sbjct:  141 IEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQ-RVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGR 299

HSP 2 Score: 79.337 bits (194), Expect = 1.231e-32
Identity = 60/210 (28.57%), Postives = 103/210 (49.05%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTL-SGIMVLIGTSDEVKLWMDKYNKARTGF 1588
             P QRITKY +LL  +   S E   Q+ L+ M +AV  FL HIN    G+ R  E +E L   ++    Y ++            R F   D+T  +        R L+  G +++   +   +DV  FLF+D+ LV K  +K  +K ++ + P+ L+KL+ +  ++ NSF+ I L +F  + S ++V   +  +   W++K  +A+   
Sbjct:  308 KPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHIN----GQVRQGEEQESLAAAAQRIGPY-EVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKA-DKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAAL 511
[Close]
BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Match: sp|O94827|PKHG5_HUMAN (Pleckstrin homology domain-containing family G member 5 OS=Homo sapiens OX=9606 GN=PLEKHG5 PE=1 SV=3)

HSP 1 Score: 75.0998 bits (183), Expect = 6.814e-28
Identity = 58/210 (27.62%), Postives = 102/210 (48.57%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDE-KQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  +   + E   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   +  + + P+ +DK++ +  ++  SF+ I LN+F +  G      +   + + W+D  YN
Sbjct:  537 LAKPHQRLTKYPLLLKSVLRKTEEPRAKEAVVAMIGSVERFIHHVNACM----RQRQERQRLAAV----VSRIDAYEVVESSSDEVDKLLKEFLHLDLTAPIPGASPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTRVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASGQALCRGWVDTIYN 737

HSP 2 Score: 72.0182 bits (175), Expect = 6.814e-28
Identity = 51/174 (29.31%), Postives = 87/174 (50.00%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW +++ G E  T+ +C +Q A+WEL+ TEAS +    ++I +FL   + LQ    E   LC+ E   LF NI ++ Q H  LW   ++  L K+R     L      +GF    S+F+ Y  +   +    + ++   + +   R YI W +++ +  R  +   +AKP
Sbjct:  371 RLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEASYIRKLRVIINLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAQLHRRLWASVMAPVLEKARRTRALLQPGDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYITWAEKHPQCQRLKLSDMLAKP 540
[Close]
BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Match: sp|Q6RFZ7|PKHG5_RAT (Pleckstrin homology domain-containing family G member 5 OS=Rattus norvegicus OX=10116 GN=Plekhg5 PE=1 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 4.315e-27
Identity = 62/205 (30.24%), Postives = 105/205 (51.22%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDE-KQDLDEMTKAVHDFLEHINSIVTGEK---RLEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  +   ++E   K+ +  M  +V  F+ H+N+ +   +   RL  +  R+   E      D VD F    ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  517 LAKPHQRLTKYPLLLKSVLRKTDEPRAKEAIITMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKFL---KEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIHLNEFHSAVGAYTFQASSQALCRSWVDTLYN 717

HSP 2 Score: 67.3958 bits (163), Expect = 4.315e-27
Identity = 49/174 (28.16%), Postives = 85/174 (48.85%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW +++ G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI +L + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  351 RLEDSWRELIDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPELARLHRGLWSSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRSLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 520
[Close]
BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Match: sp|Q66T02|PKHG5_MOUSE (Pleckstrin homology domain-containing family G member 5 OS=Mus musculus OX=10090 GN=Plekhg5 PE=1 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 5.727e-26
Identity = 58/210 (27.62%), Postives = 104/210 (49.52%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG----------RQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEV-KLWMDK-YN 1570
            L  P QR+TKY +LL  + +   +   K+ +  M  +V  F+ H+N+ +    R  + ++RL          +D + V+           ++F+  D+T  +    P+  R L+  G L++   K+  MDV CFLF DL LV K  KK   + ++ + P+ +DK++ +  ++  SF+ I LN+F +  G      +S  + + W+D  YN
Sbjct:  551 LAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCM----RQRQERQRLAGV----VSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKA-ERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYN 751

HSP 2 Score: 64.6994 bits (156), Expect = 5.727e-26
Identity = 48/174 (27.59%), Postives = 84/174 (48.28%), Query Frame = 1 
Query:  493 RIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE---LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            R+E SW ++  G E  T+ +C +Q A+WEL+ TE S +    ++  +FL   + LQ    E   LC+ E   LF NI ++ + H  LW   +   L K+R     L  S   +GF    S+F+ Y  +   +    + ++   + +   R Y+ W +++ +  R  +   +AKP
Sbjct:  385 RLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQ----ESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKP 554
[Close]
BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Match: G1PPN3 (Pleckstrin homology and RhoGEF domain containing G6 OS=Myotis lucifugus OX=59463 GN=PLEKHG6 PE=4 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 3.652e-34
Identity = 45/160 (28.12%), Postives = 84/160 (52.50%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE + +    I+ ++     + LQ +   L  +    LFGN+  L ++H   WE  +   L K+R   +PLD   +++GFL++S  F+ Y  +     Q     +EQ+  +   R +++W +++ R+ R
Sbjct:  141 IEKSWKELVPGHKEMSRELCHQQEALWELLTTELTYIRMLKIMTDLLAAGLLNLQ-RVGLLIEVSAETLFGNVPSLIRAHRSFWEEVLGPTLGKTRASGQPLDPVSLQDGFLAVSQRFQPYVQYCLRVKQTMAYAREQQDNNPLFRTFVQWCEKHKRSGR 299

HSP 2 Score: 80.8777 bits (198), Expect = 3.652e-34
Identity = 64/207 (30.92%), Postives = 106/207 (51.21%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDI-TKSLKDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVL--IGTSDEVKLWMDKYNKAR 1579
            P QRITKY +LL  + K       +Q L++M  AV  FL+HIN  V    R  E +E LV  ++    Y ++            R F   D+ +  L   P+  R L+  G  ++   +   MDV  FLF+D+ LV K  ++  +K ++ + P  L+KL+ +  ++ NSF+AI L DF  +S  +++    T+D  + W++K  +A+
Sbjct:  309 PHQRITKYPLLLQAVLKRTPEAQARQALNDMITAVESFLQHINKQV----RQGEDQENLVAAAQRIGPY-EVLEPSSEEMEKNLRPFSNLDLMSPMLGVAPEHTRQLLLEGPARVKEGREGKMDVYLFLFSDVLLVTKPQRRA-DKAKVIRPPFMLEKLVCRPLRDPNSFLAIHLTDFQCVSSALIVHCPSTADRAQ-WLEKTQQAQ 508
[Close]
BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Match: A0A2B4SCB8 (Pleckstrin-likey domain-containing family G member 5 OS=Stylophora pistillata OX=50429 GN=Plekhg5 PE=4 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.380e-33
Identity = 65/207 (31.40%), Postives = 107/207 (51.69%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKD-FSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHV------IGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGFL 1591
            P QR+TKY +LL  I +  + ED K+ L+ M   V  F+  +N+ +     LE++K       ++  +Y  +  V      I + +  +D+T+ +    D   R +IH GHL+L L+K   MDV  FLF DL L+ K  K D  K ++ K P+++DKL+    +  +F+ I +N++        L G+S +   WMD   KA+  F+
Sbjct:  561 PMQRVTKYHLLLKAIGNKTTEEDVKEVLNRMRMKVETFVSKVNAAMKERHELEKLK---TTAQKIHNNYSVVEAVNEEMEKILQDYSSYDLTRPMPGLTDDQHRSVIHEGHLRL-LEKQGKMDVYVFLFTDLLLITKAKKGD--KFKVIKPPLQVDKLVTHRDQGGAFLLIYVNEYNIAVQAFALQGSSSDQTQWMDAIKKAQKLFM 761

HSP 2 Score: 74.3294 bits (181), Expect = 1.380e-33
Identity = 48/160 (30.00%), Postives = 87/160 (54.37%), Query Frame = 1 
Query:  493 RIESSWTDIV----IGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEY 960
            ++ESSWT++V    IG    TK E D+Q AIWEL+ TEA  ++  +++ ++FL     LQ++   L  +  S+LF N+EQ+Y+ +L  W   +S  +  +R   + L+   M+ GF    + F+ Y  +   + +  K  +E+   +   + YI W +++
Sbjct:  389 KLESSWTEVVDESHIGA--MTKKENDQQEAIWELLSTEAVYISKLYVIKKLFLQCLRNLQSE-GFLLEIDASKLFNNVEQIYEVNLAFWTEHLSTVVEYARKTKDLLNPLDMEAGFNMFEAQFDPYIKYCMEESKCLKYYKEKLVENEDFKTYITWCEDH 545
[Close]
BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Match: A0A3M6UM08 (Uncharacterized protein OS=Pocillopora damicornis OX=46731 GN=pdam_00018670 PE=4 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 1.768e-33
Identity = 64/207 (30.92%), Postives = 109/207 (52.66%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHV------IGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGFL 1591
            P QR+TKY +LL  I + + E++ +D L+ M   V  F+  +N+ +     LE++K   V   ++  +Y  +  V      I + +  +D+T+ +    D   R +IH G+L+L L+K   MDV  FLF DL L+ K  K D  K ++ K P+++DKL+    +  +F+ I +N++        L GT+ +   WMD   KA+  F+
Sbjct:  565 PMQRVTKYHLLLKAIGNKTMEEDTKDVLNRMRVKVETFVSKVNAAMKERHELEKLKATAV---KIHNNYSVVEAVNEEMEKILQDYSSYDLTRPMPGLTDDQHRSVIHEGNLRL-LEKQGKMDVYVFLFTDLLLITKAKKAD--KFKVIKPPLQVDKLVTAKDQGGTFLLIYVNEYNIAVQAFALQGTASDQAQWMDAIKKAQKLFM 765

HSP 2 Score: 75.485 bits (184), Expect = 1.768e-33
Identity = 49/160 (30.63%), Postives = 88/160 (55.00%), Query Frame = 1 
Query:  493 RIESSWTDIV----IGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEY 960
            ++ESSWT++V    IG    TK E D+Q A+WEL+ TEA  ++  +I+ ++FL     LQ++   L  +  S+LF N+EQ+Y+ +L  W   +SK +  +R   + L+   M+ GF    + F+ Y  +   + +  K  +E+   +   + YI W +++
Sbjct:  393 KLESSWTEVVDERRIG--TMTKKEKDQQEAMWELLSTEAVYISKLYIIKKLFLQCLRNLQSE-GFLVEIEASKLFNNVEQIYEVNLAFWTEHLSKVVEYARKTKDLLNPLDMEAGFNMFEAQFDPYIKYCMEESKCLKYYKEKLVENEDFKTYITWCEDH 549
[Close]
BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Match: K1RE88 (Pleckstrin-like protein domain-containing family G member 5 OS=Crassostrea gigas OX=29159 GN=CGI_10025117 PE=4 SV=1)

HSP 1 Score: 88.5817 bits (218), Expect = 2.372e-33
Identity = 66/208 (31.73%), Postives = 106/208 (50.96%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNED-EKQDLDEMTKAVHDFLEHINSIVTG---EKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKD-FPD--RVLIHAGHLKLYLDKNKT-MDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGF 1588
            L  P QR+TKY +LL  I   + ED +++DL EM   V  F+ H+N  +     ++RL  I  ++     V+    +    I   +  FD+   +    PD  R LI    LKL   K+ T MDVEC LF DL L+CK  K+   K +I K P+R+D+++++  K+  SF+ I LN++               +++W++   KA+T +
Sbjct:  388 LVKPMQRLTKYSLLLQAILRKTEEDRQRRDLLEMIAGVDKFVSHVNVTLRHKHDQERLNAIVAKIESYDAVESPNDECLRYIQEYYDNFDLRAPMPGCSPDHTRTLIMQSVLKL---KDSTRMDVECLLFTDLLLICKPSKR-MEKYKIIKPPMRVDRMIIQELKDKGSFLLIYLNEYHVPVSAFTFHADQASIRVWVEHIRKAQTLY 591

HSP 2 Score: 85.1149 bits (209), Expect = 2.372e-33
Identity = 47/175 (26.86%), Postives = 88/175 (50.29%), Query Frame = 1 
Query:  490 WRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKPISK 1011
            + IE  W+ +V      TK + D+Q AIWEL+ TE   +    +++++F+   I LQ +   L  +    LFGNI  +   + + WE  + K LL++R +  PL+ S MK+GF     +F SY  +   Q   ++ ++ +   +   + ++ W +   + NR  +   + KP+ +
Sbjct:  221 FEIEPHWSSVVENASMLTKRQHDQQEAIWELLNTELHYIKALRVIVDLFMCCLINLQAE-GLLNEIETEHLFGNISDVLTVNCDFWESHLLKVLLEARENRTPLNPSDMKDGFKRFGELFGSYTKYCTEQKNCTEYMKARYADNDLFKTFVVWAETQKQCNRLKLTDLLVKPMQR 394
[Close]
BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Match: S7N897 (Pleckstrin like proteiny domain-containing family G member 6 OS=Myotis brandtii OX=109478 GN=D623_10009409 PE=4 SV=1)

HSP 1 Score: 95.5153 bits (236), Expect = 3.026e-33
Identity = 46/160 (28.75%), Postives = 84/160 (52.50%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNR 975
            IE SW ++V G +  ++  C +Q A+WEL+ TE + +    I+ ++     + LQ +   L  +    LFGN+  L ++H   WE  +   L K+R   +PLD   +++GFL+IS  F+ Y  +     Q     +EQ+  +   R +++W +++ R+ R
Sbjct:  141 IEKSWKELVPGHKEMSRELCHQQEALWELLTTELTYIRMLKIMTDLLAAGLLNLQ-RVGLLIEVSAETLFGNVPSLIRAHRSFWEEVLGPTLGKTRASGQPLDPVSLQDGFLAISQRFQPYVQYCLRVKQTMAYAREQQDNNPLFRTFVQWCEKHKRSGR 299

HSP 2 Score: 77.411 bits (189), Expect = 3.026e-33
Identity = 62/207 (29.95%), Postives = 105/207 (50.72%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIG-------RQFIVFDI-TKSLKDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVL--IGTSDEVKLWMDKYNKAR 1579
            P QRITKY +LL  + K       +Q L++M  AV  FL+HIN  V    R  E +E LV  ++    Y ++            R F   D+ +  L   P+  R L+  G  ++   +   +DV  FLF+D+ LV K  ++  +K ++ + P  L+KL+ +  ++ NSF+AI L DF  +S  +++     +D  + W++K  +A+
Sbjct:  309 PHQRITKYPLLLQAVLKRTPEAQARQALNDMITAVESFLQHINKQV----RQGEDQENLVAAAQRIGPY-EVLEPSSEEMEKNLRPFSNLDLMSPMLGVAPEHTRQLLLEGPARVKEGREGKLDVYLFLFSDVLLVTKPQRRA-DKAKVIRPPFMLEKLVCRPLRDPNSFLAIHLTDFQCVSSALIVHCPSAADRAQ-WLEKTQQAQ 508
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Match: plekhg6 (pleckstrin homology domain containing, family G (with RhoGef domain) member 6 [Source:ZFIN;Acc:ZDB-GENE-030131-2517])

HSP 1 Score: 66.2402 bits (160), Expect = 7.886e-19
Identity = 42/170 (24.71%), Postives = 84/170 (49.41%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKP 1002
            +E SWTDIV   E+ +K++  +Q A+WEL+ TE   +N   I+ E+ L     + +Q   L  +  ++LF N+  + ++H   W   +   L+  R   +P D   ++ G L  +  F +Y  +   + +  +  + Q +++   + Y+ W + + +  R  +  + AKP
Sbjct:  133 LEKSWTDIVHSHESMSKTQRHQQEALWELLQTELVYINKLTIITELVLSALEYV-HQRGFLLEVTSAQLFSNLPSILEAHKLFWRDVMYPMLINVRQTGQPFDPLKLEPGCLQFAERFSAYLDYCWEEERNVEFTRRQLESNPQFQAYLLWVETHPQCVRMRLGDMQAKP 301

HSP 2 Score: 47.7506 bits (112), Expect = 7.886e-19
Identity = 54/207 (26.09%), Postives = 93/207 (44.93%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQD-LDEMTKAVHDFLEHINSIVT---GEKRLEEIKERL--VETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPD---RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKEN-SFIAIVLNDFMTLSGIMVLIGTSDE-VKLWMDKYNKARTGF 1588
            P QRITKY +LL  I   + +   Q  L  M  +V  FL+ IN  +     E  L ++ +R+   ET  +  + +D F    ++   FD+T  ++       R L+    LK+   K+  ++V   LF D+ L+ K  KK   K ++ + PV L++      K+  SF+ +  +D      +  +   S E    W+   N+A+   
Sbjct:  301 PHQRITKYPLLLKAILKTTEDTHTQGTLHRMLNSVGQFLDSINDYLQFKDDELALFDLSQRIEGYETQGMN-EEIDKFI---QEACRFDLTSPVQGMGPTVIRKLLMEETLKVRGRKDSKLEVVALLFTDVLLLTKSQKKS-EKHKVVRPPVSLERTHCAELKDGYSFVLVEASDLGCAVNVYSVSAPSPESCTAWVSAINQAKEAL 502
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Match: plekhg5b (pleckstrin homology domain containing, family G (with RhoGef domain) member 5b [Source:ZFIN;Acc:ZDB-GENE-090908-6])

HSP 1 Score: 73.559 bits (179), Expect = 3.248e-13
Identity = 46/153 (30.07%), Postives = 77/153 (50.33%), Query Frame = 1 
Query:  487 NWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIK 945
            N  +E SW +++   E  ++ +  +Q AIWEL+ TEA+ L    ++ ++FL   + LQ+    L  +  ++LF NI+ L + H  LW + +   L ++R D   LD + M  GF + SS FE Y  +            E+E    YMR  ++
Sbjct:  386 NLTLEESWQNLLENPETLSERQLHQQEAIWELLQTEATNLKKLRVITDLFLCGLLNLQD-CGLLVEVEPAKLFNNIQDLVRVHTALWNQVMLPALERARRDRSLLDPTDMHLGFQTFSSRFEPYLRY----------CMEEESCMEYMRTQLR 527
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Match: plekhg5b (pleckstrin homology domain containing, family G (with RhoGef domain) member 5b [Source:ZFIN;Acc:ZDB-GENE-090908-6])

HSP 1 Score: 63.5438 bits (153), Expect = 4.401e-10
Identity = 55/199 (27.64%), Postives = 99/199 (49.75%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIV---TGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMT-LSGIMVLIGTSDEVKLWMD 1561
            L  P QR+TKY +LL  I K   +   K  L  M   V  F+  ++S +     +++L  I  R+     V+    ++   + R+F   D+T  + D  P+  R L   G L++   K+  M+V CFLF DL L+ K  K+   K+++ + P+ +  ++ K  K+  SF+ I LN+F + ++       ++ + + W+D
Sbjct:    2 LAKPHQRLTKYPLLLKTILKKTDDSAAKDALLNMVVCVESFINSVDSKMLQRQEKQKLAAISARVESYEAVEGSSEEVERAL-REFNRIDLTAPMIDTSPEETRQLHLEGALRMKEGKDSRMEVYCFLFTDLLLITKPVKR-LEKVKVIRQPLLIHNIVCKELKDPGSFVLIYLNEFKSAVAAYSFQANSTSQGRSWVD 198
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Match: plekhg5a (pleckstrin homology domain containing, family G (with RhoGef domain) member 5a [Source:ZFIN;Acc:ZDB-GENE-060503-766])

HSP 1 Score: 62.7734 bits (151), Expect = 7.172e-10
Identity = 56/205 (27.32%), Postives = 101/205 (49.27%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-----DYVDIFHVIGRQFIVFDITKS-LKDFPD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMT-LSGIMVLIGTSDEVKLWMDK-YN 1570
            L  P QR+TKY +LL  + K   +   ++ +  M   V  F   INS+ +  ++ EE ++     SR++         +    I R++  FD+T   +   PD  R L   G LK+   K   MDV CFLF D+ L+ K  K+   K+++ + P+ +  ++ +  K+  +F+ I LN+F T ++       ++ + + W++  YN
Sbjct:   42 LVKPHQRLTKYPLLLKSVLKKTDDPAAREAVTRMIAVVEGF---INSVDSQMRQREEKQKLTAIASRIEAYEAVEGASEEVEKILREYNQFDLTAPVMGASPDEIRQLHLEGALKMKEGKESRMDVYCFLFTDVLLITKPVKR-VEKVKVIRQPLVIQNVVCRELKDPGAFLLIYLNEFRTAVASYCFQANSATQGRSWVEAVYN 242
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Match: arhgef12b (Rho guanine nucleotide exchange factor (GEF) 12b [Source:ZFIN;Acc:ZDB-GENE-070705-36])

HSP 1 Score: 51.9878 bits (123), Expect = 2.015e-6
Identity = 48/187 (25.67%), Postives = 91/187 (48.66%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNE-DEKQDLDEMTKAVHDFLEHINSIVT---GEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLF---------LVCKQHKKD----RNKLEIFKSPVRLDKLLVKS-GKEN-SFIAIVLND 1495
            +P   QR+TKY +LL+ I  ++++ +EK  +    +   + L H+N  V     ++RLE+ + RL  +S  + +     H +  +F   D+TK       R ++H G L   ++K+KT+++   L  D+          L+ K H K+         IF   ++L  ++V+S   +N SF  + ++D
Sbjct:  884 IPVEMQRLTKYPLLLESIAKYTDDAEEKSKVKRAGECCRNILNHVNQEVKEAENKQRLEDYQRRLDLSSLKQSE-----HPMIAEFKNLDLTK-------RKMVHEGPLSWKVNKDKTIELYTLLLEDILVLMQRQDEKLILKCHSKNLAGTAETKHIFSPIIKLSTVMVRSVATDNKSFFVLSMSD 1058
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Nematostella
Match: EDO39608 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S9N2])

HSP 1 Score: 81.2629 bits (199), Expect = 1.130e-30
Identity = 65/203 (32.02%), Postives = 104/203 (51.23%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRI-KDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHV------IGRQFIVFDITKSLK--DFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKAR 1579
            P QR+TKY +LL  I K   +E+ K+ + +M   V   L  +N  +   +  E  K R V  +R++ +Y  I  V      I   +   D+ + +   D P R +IH G L+L ++K   MDV  FLF DL L+ K  K D  K  + K P+ +DKL V + K+  +F+ + +N++ T+     L G++ +   WMD   KA+
Sbjct:  565 PMQRLTKYPLLLKAIHKKTQDEEMKEGIWKMILTVESLLSKVNGAM--REMYERNKLRSV-ANRIQDNYTVIEAVNEEMEKILVNYNSLDLMEHIPGMDIP-RCVIHEGPLRL-VEKQGKMDVHVFLFTDLLLITKPKKAD--KYRVIKPPMMVDKLYVHASKDPGTFLLVYVNEYNTVVHAFALQGSNADQTQWMDAIRKAQ 760

HSP 2 Score: 70.8626 bits (172), Expect = 1.130e-30
Identity = 56/182 (30.77%), Postives = 91/182 (50.00%), Query Frame = 1 
Query:  484 GNWRIESSWTDIVIGK--ENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKS--ELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDR-TNRFGILA-IAKPISK 1011
            G   +E SWT +V  +  E  TK + D+Q AIWEL+ TE + ++   IV ++F+   + L+N   E F L     +LF NIE +Y+ +   W   + +   KSR   +PL+   M E F      FE Y ++   + +  K  +E+   +   R YI W +E+   TNR  +   + KP+ +
Sbjct:  390 GAITLEESWTAVVDPEIMETMTKKQKDQQEAIWELLFTEVTYIHKLSIVKKLFI---LCLRNVQSEGFLLDVEIEKLFSNIEDIYELNYSFWVDCLCEVAEKSRKTGKPLNPMDMNEAFPMFDKRFEPYITYCMEESRCLKYFKEKIIENEDFRTYITWCEEHRLCTNRLKLTDYLVKPMQR 568
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Nematostella
Match: EDO49694 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RG07])

HSP 1 Score: 54.299 bits (129), Expect = 1.403e-7
Identity = 59/245 (24.08%), Postives = 102/245 (41.63%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNE--DEKQDLDEMTKAVHDFLEHINSIV---TGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHK---KDRNKLE--------------------------------IFKSPVRLDKLLV------KSGK--ENSFIAIVLNDFMTLSGIMVLIGTSDEVK-LWMDKYNKARTGF 1588
            P Q +TKY +LL  I+  ++E  D+   L  + K+V   ++ +   V      +RL+E+++ LV  S V+ D         R  +     + L    +R L+H GHL L+  ++   DV  FLF+D+ L+ +  K   K   KL                                 ++K P+ LD+ +V       +G   +NSFI I  + F    G+  L   +  +K  W  +   A++ +
Sbjct:  824 PLQHLTKYPLLLKNIRKRTSEGDDQHSSLSSVIKSVELSIKELEGKVKSLANLERLQELQKCLVWPSIVELDPKTYVPEFLRGILAKQPCEGLLTSANRQLLHEGHLVLH--ESTKQDVYAFLFDDMLLLTRYRKLQPKAVKKLSLAGMAGAVAGGTESPPPTPPITRKTYHNVQYTVYKQPIPLDRFIVFDAEATHAGNTLKNSFIIIHYSRFKQTIGLYTLQAPTQNLKETWTSRLKAAQSSW 1066
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Match: plekhg5b (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:101161470])

HSP 1 Score: 78.9518 bits (193), Expect = 2.801e-28
Identity = 46/176 (26.14%), Postives = 90/176 (51.14%), Query Frame = 1 
Query:  484 GNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
             N  +E SW +++ G E  T+ +  +Q AIWEL+ TEA+ +    ++ ++FL   + LQ      E+ P   + LF NI+++ + H  LW + +   L ++R     LD +++ +GF +  + F+ Y  +   +    + ++   + +   R+YI W +   + NR  +   +AKP
Sbjct:  332 ANLILEDSWKELLDGPETLTRRQFHQQEAIWELLNTEAAYIKKLRVITDLFLSGLLNLQESGLLSEVEP---TRLFSNIQEIVRLHTSLWNQVMLPVLHRAREARALLDPTLLYDGFRTFDTRFQPYIRYCMEEESCMEYMRTLLRDNELFRKYITWAETKKQCNRLKLADMLAKP 504

HSP 2 Score: 67.0106 bits (162), Expect = 2.801e-28
Identity = 78/296 (26.35%), Postives = 137/296 (46.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDL-DEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-----DYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF-MTLSGIMVLIGTSDEVKLWMDK-YNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDE 1843
            L  P QR+TKY +LL  +   ++E   +D+   M   V  F   INS+ +  ++ +E ++    ++R+ C        +    I +++  FD+   ++   P+  R L   G L++   K+  MDV CFLF DL L+ K  K+   K+++ + P+ +  ++ K  K+  SFI I LN+F   ++       ++ + + W+D  YN       N+ +  LR    D  +    RSC  V  + E   S  T S    +H    +SS    S E + ++ + EE        SI ++E
Sbjct:  501 LAKPHQRLTKYPLLLKSVLKKTDELSARDIVSSMVVMVESF---INSVDSQMRQRQERQKLATISARIDCYEAVEGSSEEVEKILKEYNRFDLMAPMRGTSPEETRQLQLEGALRMKEGKDSRMDVYCFLFTDLLLITKPVKR-LEKVKVIRQPLLIHNIVCKELKDPGSFILIYLNEFNSAVAAYTFQANSATQGRCWIDAIYN-----IQNQLQR-LRSE-EDLRRQQRPRSCSGVDVDDESSNS--TTSSPILQHKEQQNSSHSDGSTETL-SVMDMEERSEPPPPPSINIEE 782
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Match: plekhg5b (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:101161470])

HSP 1 Score: 78.9518 bits (193), Expect = 3.273e-28
Identity = 46/176 (26.14%), Postives = 90/176 (51.14%), Query Frame = 1 
Query:  484 GNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
             N  +E SW +++ G E  T+ +  +Q AIWEL+ TEA+ +    ++ ++FL   + LQ      E+ P   + LF NI+++ + H  LW + +   L ++R     LD +++ +GF +  + F+ Y  +   +    + ++   + +   R+YI W +   + NR  +   +AKP
Sbjct:  398 ANLILEDSWKELLDGPETLTRRQFHQQEAIWELLNTEAAYIKKLRVITDLFLSGLLNLQESGLLSEVEP---TRLFSNIQEIVRLHTSLWNQVMLPVLHRAREARALLDPTLLYDGFRTFDTRFQPYIRYCMEEESCMEYMRTLLRDNELFRKYITWAETKKQCNRLKLADMLAKP 570

HSP 2 Score: 66.6254 bits (161), Expect = 3.273e-28
Identity = 78/296 (26.35%), Postives = 137/296 (46.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDL-DEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-----DYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF-MTLSGIMVLIGTSDEVKLWMDK-YNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDE 1843
            L  P QR+TKY +LL  +   ++E   +D+   M   V  F   INS+ +  ++ +E ++    ++R+ C        +    I +++  FD+   ++   P+  R L   G L++   K+  MDV CFLF DL L+ K  K+   K+++ + P+ +  ++ K  K+  SFI I LN+F   ++       ++ + + W+D  YN       N+ +  LR    D  +    RSC  V  + E   S  T S    +H    +SS    S E + ++ + EE        SI ++E
Sbjct:  567 LAKPHQRLTKYPLLLKSVLKKTDELSARDIVSSMVVMVESF---INSVDSQMRQRQERQKLATISARIDCYEAVEGSSEEVEKILKEYNRFDLMAPMRGTSPEETRQLQLEGALRMKEGKDSRMDVYCFLFTDLLLITKPVKR-LEKVKVIRQPLLIHNIVCKELKDPGSFILIYLNEFNSAVAAYTFQANSATQGRCWIDAIYN-----IQNQLQR-LRSE-EDLRRQQRPRSCSGVDVDDESSNS--TTSSPILQHKEQQNSSHSDGSTETL-SVMDMEERSEPPPPPSINIEE 848
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Match: plekhg5b (pleckstrin homology and RhoGEF domain containing G5 [Source:NCBI gene;Acc:101161470])

HSP 1 Score: 78.5666 bits (192), Expect = 3.468e-28
Identity = 46/176 (26.14%), Postives = 90/176 (51.14%), Query Frame = 1 
Query:  484 GNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQ--YDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
             N  +E SW +++ G E  T+ +  +Q AIWEL+ TEA+ +    ++ ++FL   + LQ      E+ P   + LF NI+++ + H  LW + +   L ++R     LD +++ +GF +  + F+ Y  +   +    + ++   + +   R+YI W +   + NR  +   +AKP
Sbjct:  376 ANLILEDSWKELLDGPETLTRRQFHQQEAIWELLNTEAAYIKKLRVITDLFLSGLLNLQESGLLSEVEP---TRLFSNIQEIVRLHTSLWNQVMLPVLHRAREARALLDPTLLYDGFRTFDTRFQPYIRYCMEEESCMEYMRTLLRDNELFRKYITWAETKKQCNRLKLADMLAKP 548

HSP 2 Score: 67.0106 bits (162), Expect = 3.468e-28
Identity = 78/296 (26.35%), Postives = 137/296 (46.28%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDL-DEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKC-----DYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKE-NSFIAIVLNDF-MTLSGIMVLIGTSDEVKLWMDK-YNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDE 1843
            L  P QR+TKY +LL  +   ++E   +D+   M   V  F   INS+ +  ++ +E ++    ++R+ C        +    I +++  FD+   ++   P+  R L   G L++   K+  MDV CFLF DL L+ K  K+   K+++ + P+ +  ++ K  K+  SFI I LN+F   ++       ++ + + W+D  YN       N+ +  LR    D  +    RSC  V  + E   S  T S    +H    +SS    S E + ++ + EE        SI ++E
Sbjct:  545 LAKPHQRLTKYPLLLKSVLKKTDELSARDIVSSMVVMVESF---INSVDSQMRQRQERQKLATISARIDCYEAVEGSSEEVEKILKEYNRFDLMAPMRGTSPEETRQLQLEGALRMKEGKDSRMDVYCFLFTDLLLITKPVKR-LEKVKVIRQPLLIHNIVCKELKDPGSFILIYLNEFNSAVAAYTFQANSATQGRCWIDAIYN-----IQNQLQR-LRSE-EDLRRQQRPRSCSGVDVDDESSNS--TTSSPILQHKEQQNSSHSDGSTETL-SVMDMEERSEPPPPPSINIEE 826
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Match: plekhg6 (pleckstrin homology and RhoGEF domain containing G6 [Source:NCBI gene;Acc:101169881])

HSP 1 Score: 65.0846 bits (157), Expect = 9.110e-21
Identity = 42/170 (24.71%), Postives = 83/170 (48.82%), Query Frame = 1 
Query:  496 IESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAI-AKP 1002
            +E SWTD+V      TK +  +Q A+WELI TE   +N   I+ ++ +   + L +Q   L  +   +LF N+  + Q+H   W+  +   + + R   +P D   ++EG L   + F  Y  +   +       ++Q +++ + + +I+W + + +  R  +  + AKP
Sbjct:  148 LEKSWTDLVQNHLTMTKMQRHQQEALWELISTELIYINKLKIIKDLVIAALLNL-HQRGFLQEVSPDQLFYNLPSILQAHQLFWQEVVYPMVQEVRQTGKPFDPMGLEEGCLQFHNRFLVYREYCWEEENSLDFTRKQMESNPHFQTFIQWVESHPQGERMRLGDMQAKP 316

HSP 2 Score: 55.0694 bits (131), Expect = 9.110e-21
Identity = 55/205 (26.83%), Postives = 107/205 (52.20%), Query Frame = 2 
Query: 1001 PFQRITKYKILLDRIKDFSNEDEKQ-DLDEMTKAVHDFLEHINSIVTGEKRLEE----IKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDF-PD--RVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDK---LLVKSGKENSFIAIVLNDFMTLSGIMVLI-GTSDEVKLWMDKYNKAR 1579
            P QRITKY +LL  +   + E   Q  L  M  +V+ FLE IN  +  +K+ +E    I  R VE   V+    +I   + ++   F++   ++   P+  R L+   +LK+ + K++ ++V   LF+D+ L+ K  K+    L++ + P+ LD+   + +K G  +SF+ + + +  ++  +++ + GTS     W+   N+A+
Sbjct:  316 PHQRITKYPLLLKAVLKHTVEPPVQLALIGMLSSVNIFLESINDYM--QKKDDEQALYISARRVEGYEVEGITEEIDKYV-QEICKFNLECPIRGVNPEVVRKLLLEENLKVRVRKDQKLEVVALLFSDVILLTKIQKRGEG-LKVVRPPLALDRIECIALKDG--SSFLLVEVGELQSVMNVLIFVAGTSLSCSKWVSTINQAK 514
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Match: ENSORLT00000024155.2 (Rho/Rac guanine nucleotide exchange factor 2 [Source:NCBI gene;Acc:101169675])

HSP 1 Score: 50.0618 bits (118), Expect = 7.018e-6
Identity = 50/209 (23.92%), Postives = 93/209 (44.50%), Query Frame = 2 
Query: 1007 QRITKYKILLDRIKDFS--NEDEKQDLDEMTKAVHDFLEHINSIVT---GEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSP-VRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDE-VKLWMDKYNKARTGFLNKFECPL 1612
            QRITKY +L+ R+ D +  N++E+Q L +  + + + +  ++  V      +RL+EI+ RL   +  +     +F                 +   R L+H G L   +  ++  DV+  L +D+ +  ++  +      + KSP V L+ L+V+    N    + L    T   +  L  +S E  K WM +  +A     ++ E PL
Sbjct:  393 QRITKYPVLIQRVLDNTKGNKEEEQALKKALQLLKELISSVDQEVLELDRTRRLQEIQARLDPRALAEVQEGGVFRA--------------GELLRRKLLHEGPLLWKVQGSRMKDVQVLLMSDILVFLQEKDQKFTFAALDKSPVVSLNNLIVRD-IANQERGMYLISASTPPEMYELYASSKEDRKTWMSRIQQAAVSCPSRVEFPL 586
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Match: SMESG000010407.1 (SMESG000010407.1)

HSP 1 Score: 635.95 bits (1639), Expect = 0.000e+0
Identity = 325/329 (98.78%), Postives = 325/329 (98.78%), Query Frame = 1 
Query:   10 MDICLLDDTEFGVSFTXXXXXXXXXXXXXXXXXGNMFLRRGAMRKRQSNANEDKHHSSDNLSTNEYTDDDICKHFKKERPSIGNEAFFRSPSKSANGFIRVLNVFQSGKKDIEKEDGRKKSYRLKFSEKRNISNEDPQLVISSAIMKIVEPILSGVNPGNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAIA 996
            MDICLLDDTEFGVSFTSIRRSRSSEDLSSK    NMFLRRGAMRKRQSNANEDKHHSSDNLSTNEYTDDDICKHFKKERPSIGNEAFFRSPSKSANGFIRVLNVFQSGKKDIEKEDGRKKSYRLKFSEKRNISNEDPQLVISSAIMKIVEPILSGVNPGNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAIA
Sbjct:    1 MDICLLDDTEFGVSFTSIRRSRSSEDLSSK----NMFLRRGAMRKRQSNANEDKHHSSDNLSTNEYTDDDICKHFKKERPSIGNEAFFRSPSKSANGFIRVLNVFQSGKKDIEKEDGRKKSYRLKFSEKRNISNEDPQLVISSAIMKIVEPILSGVNPGNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGILAIA 325

HSP 2 Score: 593.578 bits (1529), Expect = 0.000e+0
Identity = 291/291 (100.00%), Postives = 291/291 (100.00%), Query Frame = 2 
Query:  998 NPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDEKSYEEMLIQ 1870
            NPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDEKSYEEMLIQ
Sbjct:  327 NPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTSDEVKLWMDKYNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEIPRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKLDEKSYEEMLIQ 617
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Match: SMESG000023540.1 (SMESG000023540.1)

HSP 1 Score: 95.1301 bits (235), Expect = 3.472e-31
Identity = 63/209 (30.14%), Postives = 105/209 (50.24%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKE--RLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVL---IHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLI-GTSDEVKLWMDKYNKARTGFLNKF 1600
            L  PF R+TKYKILL  I+ +S  DEK+++ EM  AV  F+  +N  +     +++++     ++T  V     D    I  Q+   D+T  ++   ++V+   +  G +KL    +KT+DV+ FL  D+ L+ K  KK   K ++ K P+ LD + +     NSFI + LNDF  ++G+     G   ++ LW +    A       F
Sbjct:  273 LAKPFLRLTKYKILLQAIQKYSGIDEKKEIQEMIDAVDTFVSQVNEKIEETNLMKKLQNLNSFIDTYDVIEPLGDDLIPIINQYSKLDLTAPIQYGREKVIREILLQGSVKLREGTSKTVDVKLFLLTDILLITKFKKKHIGKYKVIKPPIFLDSIKIHKSNTNSFICVCLNDFNCITGLYHFSNGDQKKIDLWTETLQAAAVSLPKDF 481

HSP 2 Score: 60.077 bits (144), Expect = 3.472e-31
Identity = 41/150 (27.33%), Postives = 73/150 (48.67%), Query Frame = 1 
Query:  559 KQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE-LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            +Q+AIWEL+ TE + L     +++I++  F  L+ +Y   FP   SE +F N++ +     E W+  I   +       +     ++K+GF+ I  I E Y  +     +    +   EK++    EYIKW   ++ +NR  +   +AKP
Sbjct:  130 QQSAIWELMVTEQNFLKQIHFIVQIYVVGFEILRPKY---FPKVMSEEIFSNLKDVKTVSFEFWKYCIRPVIENYETTRQMFKPRLLKDGFIKIGEILEPYILYCTEISKCRSSISSLEKSNELFAEYIKWAMNFEESNREPLTDHLAKP 276
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Match: SMESG000023540.1 (SMESG000023540.1)

HSP 1 Score: 95.1301 bits (235), Expect = 3.651e-31
Identity = 63/209 (30.14%), Postives = 105/209 (50.24%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKE--RLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVL---IHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLI-GTSDEVKLWMDKYNKARTGFLNKF 1600
            L  PF R+TKYKILL  I+ +S  DEK+++ EM  AV  F+  +N  +     +++++     ++T  V     D    I  Q+   D+T  ++   ++V+   +  G +KL    +KT+DV+ FL  D+ L+ K  KK   K ++ K P+ LD + +     NSFI + LNDF  ++G+     G   ++ LW +    A       F
Sbjct:  244 LAKPFLRLTKYKILLQAIQKYSGIDEKKEIQEMIDAVDTFVSQVNEKIEETNLMKKLQNLNSFIDTYDVIEPLGDDLIPIINQYSKLDLTAPIQYGREKVIREILLQGSVKLREGTSKTVDVKLFLLTDILLITKFKKKHIGKYKVIKPPIFLDSIKIHKSNTNSFICVCLNDFNCITGLYHFSNGDQKKIDLWTETLQAAAVSLPKDF 452

HSP 2 Score: 60.077 bits (144), Expect = 3.651e-31
Identity = 41/150 (27.33%), Postives = 73/150 (48.67%), Query Frame = 1 
Query:  559 KQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE-LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            +Q+AIWEL+ TE + L     +++I++  F  L+ +Y   FP   SE +F N++ +     E W+  I   +       +     ++K+GF+ I  I E Y  +     +    +   EK++    EYIKW   ++ +NR  +   +AKP
Sbjct:  101 QQSAIWELMVTEQNFLKQIHFIVQIYVVGFEILRPKY---FPKVMSEEIFSNLKDVKTVSFEFWKYCIRPVIENYETTRQMFKPRLLKDGFIKIGEILEPYILYCTEISKCRSSISSLEKSNELFAEYIKWAMNFEESNREPLTDHLAKP 247
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Match: SMESG000023540.1 (SMESG000023540.1)

HSP 1 Score: 94.7449 bits (234), Expect = 4.001e-31
Identity = 63/209 (30.14%), Postives = 105/209 (50.24%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKE--RLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVL---IHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLI-GTSDEVKLWMDKYNKARTGFLNKF 1600
            L  PF R+TKYKILL  I+ +S  DEK+++ EM  AV  F+  +N  +     +++++     ++T  V     D    I  Q+   D+T  ++   ++V+   +  G +KL    +KT+DV+ FL  D+ L+ K  KK   K ++ K P+ LD + +     NSFI + LNDF  ++G+     G   ++ LW +    A       F
Sbjct:  225 LAKPFLRLTKYKILLQAIQKYSGIDEKKEIQEMIDAVDTFVSQVNEKIEETNLMKKLQNLNSFIDTYDVIEPLGDDLIPIINQYSKLDLTAPIQYGREKVIREILLQGSVKLREGTSKTVDVKLFLLTDILLITKFKKKHIGKYKVIKPPIFLDSIKIHKSNTNSFICVCLNDFNCITGLYHFSNGDQKKIDLWTETLQAAAVSLPKDF 433

HSP 2 Score: 60.077 bits (144), Expect = 4.001e-31
Identity = 41/150 (27.33%), Postives = 73/150 (48.67%), Query Frame = 1 
Query:  559 KQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE-LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            +Q+AIWEL+ TE + L     +++I++  F  L+ +Y   FP   SE +F N++ +     E W+  I   +       +     ++K+GF+ I  I E Y  +     +    +   EK++    EYIKW   ++ +NR  +   +AKP
Sbjct:   82 QQSAIWELMVTEQNFLKQIHFIVQIYVVGFEILRPKY---FPKVMSEEIFSNLKDVKTVSFEFWKYCIRPVIENYETTRQMFKPRLLKDGFIKIGEILEPYILYCTEISKCRSSISSLEKSNELFAEYIKWAMNFEESNREPLTDHLAKP 228
[Close]
BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Match: SMESG000023540.1 (SMESG000023540.1)

HSP 1 Score: 94.7449 bits (234), Expect = 4.269e-31
Identity = 63/209 (30.14%), Postives = 105/209 (50.24%), Query Frame = 2 
Query:  992 LPNPFQRITKYKILLDRIKDFSNEDEKQDLDEMTKAVHDFLEHINSIVTGEKRLEEIKE--RLVETSRVKCDYVDIFHVIGRQFIVFDITKSLKDFPDRVL---IHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQHKKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLI-GTSDEVKLWMDKYNKARTGFLNKF 1600
            L  PF R+TKYKILL  I+ +S  DEK+++ EM  AV  F+  +N  +     +++++     ++T  V     D    I  Q+   D+T  ++   ++V+   +  G +KL    +KT+DV+ FL  D+ L+ K  KK   K ++ K P+ LD + +     NSFI + LNDF  ++G+     G   ++ LW +    A       F
Sbjct:  259 LAKPFLRLTKYKILLQAIQKYSGIDEKKEIQEMIDAVDTFVSQVNEKIEETNLMKKLQNLNSFIDTYDVIEPLGDDLIPIINQYSKLDLTAPIQYGREKVIREILLQGSVKLREGTSKTVDVKLFLLTDILLITKFKKKHIGKYKVIKPPIFLDSIKIHKSNTNSFICVCLNDFNCITGLYHFSNGDQKKIDLWTETLQAAAVSLPKDF 467

HSP 2 Score: 60.077 bits (144), Expect = 4.269e-31
Identity = 41/150 (27.33%), Postives = 73/150 (48.67%), Query Frame = 1 
Query:  559 KQAAIWELIGTEASCLNFFFIVIEIFLPVFITLQNQYDELFPLCKSE-LFGNIEQLYQSHLELWERAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVLQEQEKTSIYMREYIKWTKEYDRTNRFGIL-AIAKP 1002
            +Q+AIWEL+ TE + L     +++I++  F  L+ +Y   FP   SE +F N++ +     E W+  I   +       +     ++K+GF+ I  I E Y  +     +    +   EK++    EYIKW   ++ +NR  +   +AKP
Sbjct:  116 QQSAIWELMVTEQNFLKQIHFIVQIYVVGFEILRPKY---FPKVMSEEIFSNLKDVKTVSFEFWKYCIRPVIENYETTRQMFKPRLLKDGFIKIGEILEPYILYCTEISKCRSSISSLEKSNELFAEYIKWAMNFEESNREPLTDHLAKP 262
The following BLAST results are available for this feature:
BLAST of Pleckstrin domain-containing family G member vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PLEKHG62.790e-3326.25pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG62.790e-3326.25pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG63.320e-3326.25pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG64.015e-2926.25pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG51.410e-2827.62pleckstrin homology and RhoGEF domain containing G... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rhgf-27.183e-2226.24RHo Guanine nucleotide exchange Factor [Source:Un... [more]
rhgf-27.713e-2226.24RHo Guanine nucleotide exchange Factor [Source:Un... [more]
rhgf-27.713e-2226.24RHo Guanine nucleotide exchange Factor [Source:Un... [more]
rhgf-28.355e-2226.24RHo Guanine nucleotide exchange Factor [Source:Un... [more]
prhg-12.675e-926.75pep chromosome:WBcel235:I:912415:926562:-1 gene:WB... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG426742.127e-3029.61gene:FBgn0261556 transcript:FBtr0302714[more]
CG426742.428e-3029.61gene:FBgn0261556 transcript:FBtr0302712[more]
CG426744.894e-3029.61gene:FBgn0261556 transcript:FBtr0332699[more]
CG426741.455e-2929.95gene:FBgn0261556 transcript:FBtr0332698[more]
CG426741.455e-2929.95gene:FBgn0261556 transcript:FBtr0302716[more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plekhg5b5.307e-2426.40pleckstrin homology domain containing, family G (w... [more]
plekhg5a8.686e-2425.44pleckstrin homology domain containing, family G (w... [more]
plekhg5a8.760e-2425.44pleckstrin homology domain containing, family G (w... [more]
plekhg5a9.057e-2425.44pleckstrin homology domain containing, family G (w... [more]
plekhg5a1.025e-2325.44pleckstrin homology domain containing, family G (w... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PLEKHG54.286e-2429.47pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG54.319e-2429.47pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG54.430e-2429.47pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG54.540e-2429.47pleckstrin homology and RhoGEF domain containing G... [more]
PLEKHG54.718e-2429.47pleckstrin homology and RhoGEF domain containing G... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Plekhg61.176e-3433.17pleckstrin homology domain containing, family G (w... [more]
Plekhg58.352e-2727.62pleckstrin homology domain containing, family G (w... [more]
Plekhg59.367e-2727.62pleckstrin homology domain containing, family G (w... [more]
Plekhg59.448e-2727.62pleckstrin homology domain containing, family G (w... [more]
Plekhg59.449e-2727.62pleckstrin homology domain containing, family G (w... [more]
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BLAST of Pleckstrin domain-containing family G member vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q8R0J1|PKHG6_MOUSE7.126e-3433.17Pleckstrin homology domain-containing family G mem... [more]
sp|Q3KR16|PKHG6_HUMAN1.231e-3226.25Pleckstrin homology domain-containing family G mem... [more]
sp|O94827|PKHG5_HUMAN6.814e-2827.62Pleckstrin homology domain-containing family G mem... [more]
sp|Q6RFZ7|PKHG5_RAT4.315e-2730.24Pleckstrin homology domain-containing family G mem... [more]
sp|Q66T02|PKHG5_MOUSE5.727e-2627.62Pleckstrin homology domain-containing family G mem... [more]
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BLAST of Pleckstrin domain-containing family G member vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
G1PPN33.652e-3428.13Pleckstrin homology and RhoGEF domain containing G... [more]
A0A2B4SCB81.380e-3331.40Pleckstrin-likey domain-containing family G member... [more]
A0A3M6UM081.768e-3330.92Uncharacterized protein OS=Pocillopora damicornis ... [more]
K1RE882.372e-3331.73Pleckstrin-like protein domain-containing family G... [more]
S7N8973.026e-3328.75Pleckstrin like proteiny domain-containing family ... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plekhg67.886e-1924.71pleckstrin homology domain containing, family G (w... [more]
plekhg5b3.248e-1330.07pleckstrin homology domain containing, family G (w... [more]
plekhg5b4.401e-1027.64pleckstrin homology domain containing, family G (w... [more]
plekhg5a7.172e-1027.32pleckstrin homology domain containing, family G (w... [more]
arhgef12b2.015e-625.67Rho guanine nucleotide exchange factor (GEF) 12b [... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2
Match NameE-valueIdentityDescription
EDO396081.130e-3032.02Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO496941.403e-724.08Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
plekhg5b2.801e-2826.14pleckstrin homology and RhoGEF domain containing G... [more]
plekhg5b3.273e-2826.14pleckstrin homology and RhoGEF domain containing G... [more]
plekhg5b3.468e-2826.14pleckstrin homology and RhoGEF domain containing G... [more]
plekhg69.110e-2124.71pleckstrin homology and RhoGEF domain containing G... [more]
ENSORLT00000024155.27.018e-623.92Rho/Rac guanine nucleotide exchange factor 2 [Sour... [more]
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BLAST of Pleckstrin domain-containing family G member vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000010407.10.000e+098.78SMESG000010407.1[more]
SMESG000023540.13.472e-3130.14SMESG000023540.1[more]
SMESG000023540.13.651e-3130.14SMESG000023540.1[more]
SMESG000023540.14.001e-3130.14SMESG000023540.1[more]
SMESG000023540.14.269e-3130.14SMESG000023540.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30019301 ID=SMED30019301|Name=Pleckstrin domain-containing family G member|organism=Schmidtea mediterranea sexual|type=transcript|length=1887bp
ATGTTATACATGGACATCTGCCTATTGGATGATACCGAATTCGGCGTATC
TTTTACTAGCATTAGAAGGTCTAGAAGTAGTGAAGATCTCTCTTCAAAGT
TATCTGAAGGAAATATGTTTTTAAGAAGAGGTGCAATGAGGAAAAGACAG
TCCAATGCAAACGAAGATAAACACCATTCATCAGACAACCTATCAACAAA
TGAATACACCGACGACGATATTTGTAAACACTTTAAAAAGGAAAGACCAT
CAATAGGAAACGAGGCCTTTTTTAGGTCACCGTCAAAATCTGCAAATGGA
TTTATTCGAGTACTCAACGTCTTTCAATCTGGGAAAAAAGATATTGAAAA
GGAGGATGGAAGAAAGAAATCATACAGATTAAAATTTTCTGAAAAAAGGA
ACATTTCAAATGAAGACCCCCAACTGGTAATCTCAAGTGCTATAATGAAA
ATAGTAGAACCGATTTTAAGCGGCGTAAATCCCGGAAATTGGCGAATCGA
ATCCTCGTGGACAGACATCGTAATTGGGAAGGAGAATTTTACTAAATCCG
AATGCGACAAGCAGGCTGCCATTTGGGAGCTGATTGGGACAGAAGCAAGT
TGTTTGAATTTCTTTTTTATCGTCATAGAAATATTTTTACCCGTGTTTAT
CACTCTACAGAATCAATATGACGAATTATTTCCACTTTGCAAATCCGAAC
TGTTCGGCAATATAGAGCAATTGTACCAGAGCCATTTGGAATTATGGGAG
CGAGCCATTTCAAAACCTCTCCTCAAGTCAAGAATTGACAATGAACCTTT
GGACATATCAGTTATGAAAGAAGGGTTTTTATCGATCTCGTCAATCTTTG
AGAGCTATAACTCATTTATGCACATGCAATGCCAGATCAGCAAGGTTCTC
CAAGAGCAGGAGAAGACAAGCATCTACATGAGAGAGTATATCAAGTGGAC
AAAGGAATACGACAGAACAAACCGGTTTGGAATCCTGGCCATTGCCAAAC
CCATTTCAAAGGATAACGAAATACAAAATATTGCTTGACCGAATAAAGGA
TTTTTCCAATGAGGATGAGAAGCAAGATCTTGATGAAATGACCAAAGCAG
TTCATGATTTCCTTGAGCATATCAATTCAATTGTGACGGGAGAGAAAAGA
CTGGAGGAAATCAAGGAAAGATTGGTAGAAACCTCACGAGTGAAATGCGA
TTATGTCGACATTTTTCACGTCATTGGCCGCCAATTCATCGTGTTTGACA
TCACTAAATCCTTGAAAGACTTCCCAGATCGGGTCTTGATTCATGCGGGC
CACTTGAAACTGTATTTGGATAAAAATAAAACAATGGACGTAGAGTGCTT
CCTGTTTAATGACCTCTTTCTAGTATGCAAGCAGCATAAAAAGGATAGGA
ATAAGCTAGAAATATTCAAATCTCCTGTAAGATTAGACAAGCTCCTTGTG
AAATCAGGAAAAGAAAATTCTTTCATTGCTATAGTTTTAAACGATTTTAT
GACGCTTAGTGGGATCATGGTTTTGATCGGAACGAGTGACGAGGTGAAGC
TTTGGATGGATAAATACAACAAAGCCAGGACCGGCTTTTTGAACAAATTT
GAATGTCCGTTGAGAGTGCCGTTGAATGATTTCTATCAAATCTCCGAGCA
AAGAAGCTGTGGAGACGTATTATTCAACGGAGAAATTCCAAGGTCTTTAC
GGACAGATAGTGACGCGACCTCAGAACATTCTTTGTGTACAGATTCTTCG
GACAAACAAATGTCTGTTGAAATGGTCGATACAATACAGGAGAATGAAGA
AAACGAAAATAGTCTAAAATTTTCATCAATTAAATTAGATGAAAAATCAT
ATGAAGAAATGTTGATTCAATAATTTTTTTATCCATC
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protein sequence of SMED30019301-orf-1

>SMED30019301-orf-1 ID=SMED30019301-orf-1|Name=SMED30019301-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=346bp
MLYMDICLLDDTEFGVSFTSIRRSRSSEDLSSKLSEGNMFLRRGAMRKRQ
SNANEDKHHSSDNLSTNEYTDDDICKHFKKERPSIGNEAFFRSPSKSANG
FIRVLNVFQSGKKDIEKEDGRKKSYRLKFSEKRNISNEDPQLVISSAIMK
IVEPILSGVNPGNWRIESSWTDIVIGKENFTKSECDKQAAIWELIGTEAS
CLNFFFIVIEIFLPVFITLQNQYDELFPLCKSELFGNIEQLYQSHLELWE
RAISKPLLKSRIDNEPLDISVMKEGFLSISSIFESYNSFMHMQCQISKVL
QEQEKTSIYMREYIKWTKEYDRTNRFGILAIAKPISKDNEIQNIA*
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protein sequence of SMED30019301-orf-2

>SMED30019301-orf-2 ID=SMED30019301-orf-2|Name=SMED30019301-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=262bp
MTKAVHDFLEHINSIVTGEKRLEEIKERLVETSRVKCDYVDIFHVIGRQF
IVFDITKSLKDFPDRVLIHAGHLKLYLDKNKTMDVECFLFNDLFLVCKQH
KKDRNKLEIFKSPVRLDKLLVKSGKENSFIAIVLNDFMTLSGIMVLIGTS
DEVKLWMDKYNKARTGFLNKFECPLRVPLNDFYQISEQRSCGDVLFNGEI
PRSLRTDSDATSEHSLCTDSSDKQMSVEMVDTIQENEENENSLKFSSIKL
DEKSYEEMLIQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: molecular function
TermDefinition
GO:0005085guanyl-nucleotide exchange factor activity
GO:0005089Rho guanyl-nucleotide exchange factor activity
Vocabulary: biological process
TermDefinition
GO:0007165signal transduction
GO:0035023regulation of Rho protein signal transduction
GO:0043547positive regulation of GTPase activity
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
Vocabulary: INTERPRO
TermDefinition
IPR035899DBL_dom_sf
IPR040181PKHG5/7
IPR000219DH-domain
IPR011993PH-like_dom_sf
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR035899Dbl homology (DH) domain superfamilyGENE3DG3DSA:1.20.900.10coord: 19..198
e-value: 9.6E-19
score: 69.9
IPR035899Dbl homology (DH) domain superfamilySUPERFAMILYSSF48065DBL homology domain (DH-domain)coord: 13..198
IPR000219Dbl homology (DH) domainPFAMPF00621RhoGEFcoord: 43..198
e-value: 1.3E-15
score: 58.1
IPR000219Dbl homology (DH) domainPROSITEPS50010DH_2coord: 38..198
score: 17.473
NoneNo IPR availablePANTHERPTHR13217:SF11RHO GUANINE NUCLEOTIDE EXCHANGE FACTORcoord: 15..198
IPR040181Pleckstrin homology domain-containing family G member 5/7PANTHERPTHR13217FAMILY NOT NAMEDcoord: 15..198