FHA domain-containing protein
Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019275 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: NBN (nibrin [Source:HGNC Symbol;Acc:HGNC:7652]) HSP 1 Score: 110.538 bits (275), Expect = 1.335e-24 Identity = 87/317 (27.44%), Postives = 143/317 (45.11%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKAPLINK-KGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLI--------------LKGINKRLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL ++ +T+ D SK+GTF+N+ + N +K GD +TFG G + S L + + L Q + +GG + N ++ ++VM ++K T K +CALI IVK ++ + + Q P + + P + P +D +RK +F K F FL ++ LS AV+ GGG A L+T+ + + + + C V T + N +LI L+ R I ++EIG AV+ + YC+P Sbjct: 18 LLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQTDEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVF-GSKFRIEYEPLVACSSCLDVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQP-PQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEHNFFLAPGTC-------VVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDP 325
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: NBN (nibrin [Source:HGNC Symbol;Acc:HGNC:7652]) HSP 1 Score: 84.7297 bits (208), Expect = 1.510e-16 Identity = 65/244 (26.64%), Postives = 107/244 (43.85%), Query Frame = 1 Query: 280 IKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLI--------------LKGINKRLINDSEIGFAVMLASVDEYCNP 969 +K GD +TFG G + S L + + L Q + +GG + N ++ ++VM ++K T K +CALI IVK ++ + + Q P + + P + P +D +RK +F K F FL ++ LS AV+ GGG A L+T+ + + + + C V T + N +LI L+ R I ++EIG AV+ + YC+P Sbjct: 9 LKSGDGITFGVF-GSKFRIEYEPLVACSSCLDVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQP-PQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEHNFFLAPGTC-------VVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDP 243
BLAST of FHA domain-containing protein vs. Ensembl Human
Match: NBN (nibrin [Source:HGNC Symbol;Acc:HGNC:7652]) HSP 1 Score: 62.003 bits (149), Expect = 1.069e-10 Identity = 44/159 (27.67%), Postives = 72/159 (45.28%), Query Frame = 1 Query: 277 NIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGG 753 +K GD +TFG G + S L + + L Q + +GG + N ++ ++VM ++K T K +CALI IVK ++ + + Q P + + P + P +D +RK +F K F FL ++ LS AV+ GG Sbjct: 8 TLKSGDGITFGVF-GSKFRIEYEPLVACSSCLDVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQ-PPQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGG 164
BLAST of FHA domain-containing protein vs. Ensembl Fly
Match: nbs (gene:FBgn0261530 transcript:FBtr0306039) HSP 1 Score: 100.908 bits (250), Expect = 8.849e-22 Identity = 80/309 (25.89%), Postives = 142/309 (45.95%), Query Frame = 1 Query: 112 YTIGRVSADVILTHT-SISRKHAVLIWECDLN---YITIDDC-SKFGTFI--------NKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGIN--QILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVK---LAHCDSIVMQ-----EAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNP 969 YTIGR++ D+I+ SISR HA L+ + + + + I+D S++GTFI K P + G + FGA + + + S L+ ++ L + L +GG + N ++ ++ M+ + T K++ A+++ IV + + M+ + I+ + P P+ Y P +D P+R LF K F F+ ++ + V G C+D + V+ L D IV+Q ++ T +N I IL+ +R+I + EIG A++ S+ E+CNP Sbjct: 20 YTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKNSQKPRKVPA-KTSTPLPVGTRLRFGANMSI-WQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQP---------TNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGAT--------CKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDILEQNGRRIIQEYEIGMALIHCSITEFCNP 309
BLAST of FHA domain-containing protein vs. Ensembl Fly
Match: nbs (gene:FBgn0261530 transcript:FBtr0306040) HSP 1 Score: 97.0561 bits (240), Expect = 1.366e-20 Identity = 80/311 (25.72%), Postives = 142/311 (45.66%), Query Frame = 1 Query: 112 YTIGRVSADVILTHT-SISRKHAVLIWECDLN---YITIDDC-SKFGTFI--------NKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGIN--QILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVK---LAHCDSIVMQ-----EAVTTNLVNEIS--LILKGINKRLINDSEIGFAVMLASVDEYCNP 969 YTIGR++ D+I+ SISR HA L+ + + + + I+D S++GTFI K P + G + FGA + + + S L+ ++ L + L +GG + N ++ ++ M+ + T K++ A+++ IV + + M+ + I+ + P P+ Y P +D P+R LF K F F+ ++ + V G C+D + V+ L D IV+Q ++ T +N I IL+ +R+I + EIG A++ S+ E+CNP Sbjct: 20 YTIGRLATDLIVAQDLSISRNHAQLLIQTEADGDDTLHIEDLGSRYGTFIFPKNSQKPRKVPA-KTSTPLPVGTRLRFGANMSI-WQVTQLKLVTTVSALTRSEVQELTKMLEPMGGTVTSNWTEECSHLTMNEVSVTVKLLHAMLENKPIVTFPYWRKMLQAAQSIHVKEGWPQPEDYQP---------TNIDVTWRPERTRLFAGKTFVFMNRKHFDMYGSVVQKAGAT--------CKDINSGVRKTFLTKSDVIVIQYVPSSQSQATESINSIQDRYILEQNGRRIIQEYEIGMALIHCSITEFCNP 311
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: nbn (nibrin [Source:NCBI gene;Acc:544655]) HSP 1 Score: 137.887 bits (346), Expect = 1.286e-33 Identity = 103/337 (30.56%), Postives = 161/337 (47.77%), Query Frame = 1 Query: 55 WKF---ENKNKNIVKYFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDP--DHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTN-----------LVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKEN 1005 WK E+ ++++ L Y +GR + +++LT+ SISR HAVL +T+ D SK+GTF+N L ++ G +TFG Q L + +VCS+ + N +V L Q + +GG L+ + ++VM +K T K +CAL+ IVK F A+ K + Q LP P + + P+I P +D P+RK LF K F FL+ +++ LS AV GGG++ LL + +L V L S + + ++ N ++ + IL R I +SE+G A + S YCNP +L K N Sbjct: 2 WKLQPTESGGESVI--LLAGQEYVVGRKNCEILLTNDQSISRVHAVLT--VTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECI---VVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALS---KAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEG-----ALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTN 323
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: nbn (nibrin [Source:NCBI gene;Acc:544655]) HSP 1 Score: 137.887 bits (346), Expect = 1.371e-33 Identity = 103/337 (30.56%), Postives = 161/337 (47.77%), Query Frame = 1 Query: 55 WKF---ENKNKNIVKYFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDP--DHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTN-----------LVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKEN 1005 WK E+ ++++ L Y +GR + +++LT+ SISR HAVL +T+ D SK+GTF+N L ++ G +TFG Q L + +VCS+ + N +V L Q + +GG L+ + ++VM +K T K +CAL+ IVK F A+ K + Q LP P + + P+I P +D P+RK LF K F FL+ +++ LS AV GGG++ LL + +L V L S + + ++ N ++ + IL R I +SE+G A + S YCNP +L K N Sbjct: 2 WKLQPTESGGESVI--LLAGQEYVVGRKNCEILLTNDQSISRVHAVLT--VTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECI---VVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALS---KAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEG-----ALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTN 323
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: nbn (nibrin [Source:NCBI gene;Acc:544655]) HSP 1 Score: 137.502 bits (345), Expect = 1.680e-33 Identity = 103/337 (30.56%), Postives = 161/337 (47.77%), Query Frame = 1 Query: 55 WKF---ENKNKNIVKYFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDP--DHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTN-----------LVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKEN 1005 WK E+ ++++ L Y +GR + +++LT+ SISR HAVL +T+ D SK+GTF+N L ++ G +TFG Q L + +VCS+ + N +V L Q + +GG L+ + ++VM +K T K +CAL+ IVK F A+ K + Q LP P + + P+I P +D P+RK LF K F FL+ +++ LS AV GGG++ LL + +L V L S + + ++ N ++ + IL R I +SE+G A + S YCNP +L K N Sbjct: 2 WKLQPTESGGESVI--LLAGQEYVVGRKNCEILLTNDQSISRVHAVLT--VTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECI---VVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALS---KAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEG-----ALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTN 323
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Match: nbn (nibrin [Source:NCBI gene;Acc:544655]) HSP 1 Score: 60.4622 bits (145), Expect = 2.005e-10 Identity = 47/154 (30.52%), Postives = 78/154 (50.65%), Query Frame = 1 Query: 55 WKF---ENKNKNIVKYFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKV 495 WK E+ ++++ L Y +GR + +++LT+ SISR HAVL +T+ D SK+GTF+N L ++ G +TFG Q L + +VCS+ + N +V L Q + +GG L+ + ++VM +K T K+ Sbjct: 2 WKLQPTESGGESVI--LLAGQEYVVGRKNCEILLTNDQSISRVHAVLT--VTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECI---VVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKI 148
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: adcy9 (adenylate cyclase 9 [Source:Xenbase;Acc:XB-GENE-999257]) HSP 1 Score: 124.02 bits (310), Expect = 5.387e-29 Identity = 100/319 (31.35%), Postives = 162/319 (50.78%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKA---PLINKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDH--YLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAML---LTDSDCRDQSLR--VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 Y L Y +GR + +++ SISR HA L ++ +TI D SK+GT ++ P + + ++K D V FG + + V ++ +VCS+ L N ++ LKQ L +GG++L N +K ++VM+++K T K +CALI I+K D+ + +++ I Q P P++ ++P I P LD N KRK +F +K F FL ++ LS AVL GGG A L LTD+ + S + +A ++ + + T ++ +L R I ++EIG AV+ S + YCNP R Sbjct: 15 YILTGTDYVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKDSSKYGTTVSGERMQPAVPR--SLKPSDEVIFGC-----FHSKYRVEYEPLVVCSSCLDNTEKNSLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELIN---AIQQKRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHLLESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISSTLDLLHSKGLRAIPEAEIGLAVINVSTEIYCNPRR 323
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: adcy9 (adenylate cyclase 9 [Source:Xenbase;Acc:XB-GENE-999257]) HSP 1 Score: 123.635 bits (309), Expect = 6.958e-29 Identity = 100/319 (31.35%), Postives = 162/319 (50.78%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKA---PLINKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDH--YLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAML---LTDSDCRDQSLR--VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 Y L Y +GR + +++ SISR HA L ++ +TI D SK+GT ++ P + + ++K D V FG + + V ++ +VCS+ L N ++ LKQ L +GG++L N +K ++VM+++K T K +CALI I+K D+ + +++ I Q P P++ ++P I P LD N KRK +F +K F FL ++ LS AVL GGG A L LTD+ + S + +A ++ + + T ++ +L R I ++EIG AV+ S + YCNP R Sbjct: 15 YILTGTDYVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKDSSKYGTTVSGERMQPAVPR--SLKPSDEVIFGC-----FHSKYRVEYEPLVVCSSCLDNTEKNSLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELIN---AIQQKRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHLLESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISSTLDLLHSKGLRAIPEAEIGLAVINVSTEIYCNPRR 323
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: adcy9 (adenylate cyclase 9 [Source:Xenbase;Acc:XB-GENE-999257]) HSP 1 Score: 123.635 bits (309), Expect = 7.402e-29 Identity = 100/319 (31.35%), Postives = 162/319 (50.78%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKA---PLINKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDH--YLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAML---LTDSDCRDQSLR--VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 Y L Y +GR + +++ SISR HA L ++ +TI D SK+GT ++ P + + ++K D V FG + + V ++ +VCS+ L N ++ LKQ L +GG++L N +K ++VM+++K T K +CALI I+K D+ + +++ I Q P P++ ++P I P LD N KRK +F +K F FL ++ LS AVL GGG A L LTD+ + S + +A ++ + + T ++ +L R I ++EIG AV+ S + YCNP R Sbjct: 15 YILTGTDYVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKDSSKYGTTVSGERMQPAVPR--SLKPSDEVIFGC-----FHSKYRVEYEPLVVCSSCLDNTEKNSLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELIN---AIQQKRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHLLESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISSTLDLLHSKGLRAIPEAEIGLAVINVSTEIYCNPRR 323
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Match: adcy9 (adenylate cyclase 9 [Source:Xenbase;Acc:XB-GENE-999257]) HSP 1 Score: 123.635 bits (309), Expect = 7.637e-29 Identity = 100/319 (31.35%), Postives = 162/319 (50.78%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKA---PLINKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDH--YLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAML---LTDSDCRDQSLR--VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 Y L Y +GR + +++ SISR HA L ++ +TI D SK+GT ++ P + + ++K D V FG + + V ++ +VCS+ L N ++ LKQ L +GG++L N +K ++VM+++K T K +CALI I+K D+ + +++ I Q P P++ ++P I P LD N KRK +F +K F FL ++ LS AVL GGG A L LTD+ + S + +A ++ + + T ++ +L R I ++EIG AV+ S + YCNP R Sbjct: 29 YILTGTDYVVGRKNCAILIPDDQSISRCHATLSVSYPSASLSQTNAVSVLTIKDSSKYGTTVSGERMQPAVPR--SLKPSDEVIFGC-----FHSKYRVEYEPLVVCSSCLDNTEKNSLKQNLIHLGGHMLNNWTEKCTHLVMTSIKVTIKTICALICCKPIIKPDYFRELIN---AIQQKRPLPEYRSFIPPIDEPSLNPESLDLSENVKRKSIFKDKVFLFLNTKQYMKLSPAVLLGGGKAHLLESLTDTSVLENSTTCVIDVAMTETQLSETQSTQPWISSTLDLLHSKGLRAIPEAEIGLAVINVSTEIYCNPRR 337
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Nbn (nibrin [Source:MGI Symbol;Acc:MGI:1351625]) HSP 1 Score: 122.865 bits (307), Expect = 9.157e-29 Identity = 97/316 (30.70%), Postives = 152/316 (48.10%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVL--------IWECD-LNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLV------NEISLILKGINK---RLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL + + D + +TI D SK+GTF+N+ + +K GD VTFG F V ++ +VCS+ L + + +L Q + +GG N ++ ++VMS +K T K +CALI I+K ++ + + Q PD + + P I P +D +RK +F K F FL ++ LS AV GGG A L+ + D +QS C +V T L+ I LI+ + + R I ++EIG AV+ + + YCNP Sbjct: 18 LLAGVEYVVGRKNCGILIENDQSISRNHAVLTVNFPVTSLSQTDEIPTLTIKDNSKYGTFVNEEKMQTGLSCTLKTGDRVTFGV-----FESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAVESKKQP-PDIESFYPPIDEPAIGSKSVDLSGRHERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQSFFSAPGTC--VVDVGITNTQLIISHSQKKWIHLIMDTLQRNGLRPIPEAEIGLAVIFMTTENYCNP 325
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Match: Nbn (nibrin [Source:MGI Symbol;Acc:MGI:1351625]) HSP 1 Score: 121.709 bits (304), Expect = 1.066e-28 Identity = 98/317 (30.91%), Postives = 154/317 (48.58%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVL--------IWECD-LNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVT-TNLV------NEISLILKGINK---RLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL + + D + +TI D SK+GTF+N+ + +K GD VTFG F V ++ +VCS+ L + + +L Q + +GG N ++ ++VMS +K T K +CALI I+K ++ + + Q PD + + P I P +D +RK +F K F FL ++ LS AV GGG A L+ + D +QS C V+ +T T L+ I LI+ + + R I ++EIG AV+ + + YCNP Sbjct: 18 LLAGVEYVVGRKNCGILIENDQSISRNHAVLTVNFPVTSLSQTDEIPTLTIKDNSKYGTFVNEEKMQTGLSCTLKTGDRVTFGV-----FESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAVESKKQP-PDIESFYPPIDEPAIGSKSVDLSGRHERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQSFFSAPGTC---VVDVGITNTQLIISHSQKKWIHLIMDTLQRNGLRPIPEAEIGLAVIFMTTENYCNP 325
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9DE07|NBN_CHICK (Nibrin OS=Gallus gallus OX=9031 GN=NBN PE=1 SV=1) HSP 1 Score: 139.428 bits (350), Expect = 2.501e-33 Identity = 97/315 (30.79%), Postives = 155/315 (49.21%), Query Frame = 1 Query: 94 FLPSVTYTIGRVS-ADVILTHTSISRKHAVLI---------WECDLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHC-------DSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 L Y +GR + A +I SISR HAVL + +TI D SK+GTF+N + L +++ GD V FG F V ++ +VCS+ L A + L + + +GG ++ + +++M ++K T K +CALI IVK +F ++ + Q LP P+ + P + P +D +P+RK +F+ K F FLT ++ L AV+ GGG A L+ + + ++ SL V C +S ++ N + I +L+ N R I ++EIG AV+ S + YCNP R Sbjct: 16 LLVGTEYVVGRKNCAFLIQDDQSISRSHAVLTVSRPETTHSQSVSVPVLTIKDTSKYGTFVNGSKLSGASRSLQSGDRVNFGV-----FESKFRVEYESLVVCSSCLDVAQKTALNEAIQQLGGLVVNEWTKECTHLIMESVKVTVKTICALICGRPIVKPEFFSELMKAVQSRQQ-LPTPESFYPSVDEPAIGIDNMDLSGHPERKKIFSGKTFVFLTAKQHKKLGPAVILGGGEAKLMAE-ERKETSLLVSPEVCVVDVGVTNSQILGSESMRNWTDSILAVLESNNLRAIPEAEIGLAVIFMSTEIYCNPQR 323
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q5I2W8|NBN_DANRE (Nibrin OS=Danio rerio OX=7955 GN=nbn PE=2 SV=2) HSP 1 Score: 137.502 bits (345), Expect = 1.268e-32 Identity = 103/337 (30.56%), Postives = 161/337 (47.77%), Query Frame = 1 Query: 55 WKF---ENKNKNIVKYFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDP--DHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTN-----------LVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKEN 1005 WK E+ ++++ L Y +GR + +++LT+ SISR HAVL +T+ D SK+GTF+N L ++ G +TFG Q L + +VCS+ + N +V L Q + +GG L+ + ++VM +K T K +CAL+ IVK F A+ K + Q LP P + + P+I P +D P+RK LF K F FL+ +++ LS AV GGG++ LL + +L V L S + + ++ N ++ + IL R I +SE+G A + S YCNP +L K N Sbjct: 2 WKLQPTESGGESVI--LLAGQEYVVGRKNCEILLTNDQSISRVHAVLT--VTEQAVTLKDSSKYGTFVNGEKLESGSTKTLQTGYKITFGVFQSKFSLEKECI---VVCSSCVDNEGKVTLSQDIRSVGGRLVSSWTSDCTHLVMPTVKVTIKTICALLCCRPIVKPAFFSALS---KAVQQKLPLPKAERFRPQIDEPSLARDDVDLSARPERKSLFKGKTFLFLSSKQMKRLSVAVSCGGGVSQLLDEG-----ALPVSLLESSSTCVLDMISGNSQPVISPASKKWLDSVGQILHRKGLRFITESEVGLAAIHVSNQTYCNPCSSLQSESVKTN 323
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9R207|NBN_MOUSE (Nibrin OS=Mus musculus OX=10090 GN=Nbn PE=1 SV=1) HSP 1 Score: 122.865 bits (307), Expect = 6.405e-28 Identity = 97/316 (30.70%), Postives = 152/316 (48.10%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVL--------IWECD-LNYITIDDCSKFGTFINKAPL-INKKGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLV------NEISLILKGINK---RLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL + + D + +TI D SK+GTF+N+ + +K GD VTFG F V ++ +VCS+ L + + +L Q + +GG N ++ ++VMS +K T K +CALI I+K ++ + + Q PD + + P I P +D +RK +F K F FL ++ LS AV GGG A L+ + D +QS C +V T L+ I LI+ + + R I ++EIG AV+ + + YCNP Sbjct: 18 LLAGVEYVVGRKNCGILIENDQSISRNHAVLTVNFPVTSLSQTDEIPTLTIKDNSKYGTFVNEEKMQTGLSCTLKTGDRVTFGV-----FESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANNWTEECTHLVMSAVKVTIKTICALICGRPIIKPEYFSEFLKAVESKKQP-PDIESFYPPIDEPAIGSKSVDLSGRHERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQSFFSAPGTC--VVDVGITNTQLIISHSQKKWIHLIMDTLQRNGLRPIPEAEIGLAVIFMTTENYCNP 325
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|Q9JIL9|NBN_RAT (Nibrin OS=Rattus norvegicus OX=10116 GN=Nbn PE=1 SV=2) HSP 1 Score: 119.013 bits (297), Expect = 1.334e-26 Identity = 95/314 (30.25%), Postives = 152/314 (48.41%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVL--------IWECD-LNYITIDDCSKFGTFINKAPLINK-KGNIKDGDIVTFGAQPGVDLNCSF-VAFD--IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIV----MQEAVTTNLVNEISLILKGINK---RLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL + + D + +TI D SK+GTFIN+ + N +K GD VTFG F V ++ +VCS+ L + + +L Q + +GG + ++ ++ MS++K T K +CALI IVK ++ + + Q P+ + + P I P +D +RK +F K F FL ++ L AV+ GGG A L+ + +QS C V Q +T + I LI+ + + R I ++EIG AV+ + + YCNP Sbjct: 18 LLAGVEYIVGRKNCAILIENDQSISRNHAVLRVNFPVTSLSQTDEIPTLTIKDNSKYGTFINEEKMQNGLSSTLKTGDRVTFGV-----FESKFRVEYEPLVVCSSCLDVSGKTVLNQAILQLGGLTANSWTEECTHLAMSSVKVTIKTICALICGRPIVKPEYFSEFLKAVESKTQP-PEIESFYPPIDEPAIGNKSVDLSGRRERKQIFKGKTFVFLNAKQHKKLGSAVVFGGGEARLMAEGGEEEQSFFSAPGTCVVDVGITNTQLIITDSQRKWIHLIMDILQRHGLRPIPEAEIGLAVIFMTTESYCNP 325
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Match: sp|O60934|NBN_HUMAN (Nibrin OS=Homo sapiens OX=9606 GN=NBN PE=1 SV=1) HSP 1 Score: 110.538 bits (275), Expect = 6.411e-24 Identity = 87/317 (27.44%), Postives = 143/317 (45.11%), Query Frame = 1 Query: 94 FLPSVTYTIGRVSADVILTH-TSISRKHAVLIWEC---------DLNYITIDDCSKFGTFINKAPLINK-KGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLI--------------LKGINKRLINDSEIGFAVMLASVDEYCNP 969 L V Y +GR + +++ + SISR HAVL ++ +T+ D SK+GTF+N+ + N +K GD +TFG G + S L + + L Q + +GG + N ++ ++VM ++K T K +CALI IVK ++ + + Q P + + P + P +D +RK +F K F FL ++ LS AV+ GGG A L+T+ + + + + C V T + N +LI L+ R I ++EIG AV+ + YC+P Sbjct: 18 LLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQTDEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVF-GSKFRIEYEPLVACSSCLDVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQP-PQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEHNFFLAPGTC-------VVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDP 325
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A4S2MI43 (FHA domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000762 PE=4 SV=1) HSP 1 Score: 166.392 bits (420), Expect = 7.494e-40 Identity = 102/316 (32.28%), Postives = 164/316 (51.90%), Query Frame = 1 Query: 112 YTIGRVSADVILTHTSISRKHAVLIWEC----DLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLD---YKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSI--------------VMQEAVTTNLVNEISLI---LKGINKRLINDSEIGFAVMLASVDEYCNPYRALPK 987 +T+GR+ AD+I+ S+SRKHA L + L +I + D SKFGTF+N PL K +K GD VTFG QPGV+ + ++ S+++ A+R +K +++ G L+ C D ++VM +L T KVVCAL+ + IV +++ ++ I + P+ +++LP + ++ + D + PN KR LF K F+ LT S LS V GGG +L+ S+ Q + C ++ V+ L + ++ L+GI +R I +SE+GFAV+ S + YCNP P+ Sbjct: 26 FTVGRIDADIIIPDKSVSRKHAGLEIQAAQSGGLEFI-LHDHSKFGTFVNGIPLNGSKRILKKGDKVTFGVQPGVNFSLQETVLNVAVSSMNKAERQRIKTITNLLHGELVPTCTDSCTFLVMPHLVVTVKVVCALLAMVPIVTPLYMEKFLEAASYIPFVRPNFENFLPPVR--EERLVDSDAIRFLPNAKRPSLFMGKVFFVLTHAHFSELSPIVRLGGGKVVLIDSSEAFVQHYEEQSGTCGNVERDLQEVLRREGSCVIHAQSVPGLEDWQRVVYSALRGIRRRPILESELGFAVLYISTNGYCNPETKCPE 338
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A4V6AQV8 (Nibrin Nijmegen breakage syndrome protein 1-like protein OS=Collichthys lucidus OX=240159 GN=D9C73_016161 PE=4 SV=1) HSP 1 Score: 152.91 bits (385), Expect = 4.181e-35 Identity = 112/323 (34.67%), Postives = 155/323 (47.99%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVIL-THTSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLI-NKKGNIKDGDIVTFGAQPGVDLNCSFVAF---DIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDP--DHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDC-RD-----QSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPK 1017 Y L S Y +GR + D++L + SISR HA L +T+ D SK+GTF+N L N N+K GD VTFG F +VCS+ L N + L Q L +GG L+ ++VM K T K +CAL+ IVK +F + K Q LP P + ++PEI P ++ P RK LF K F FL+ ++L LS AV GGG + LL + RD QS + S + + TT N + I++ R+I +SEIG A + AS D+YCNP R + S NP+ Sbjct: 15 YLLSSKDYVVGRKNCDILLPSDQSISRAHAHLT--ATGQTLTLKDTSKYGTFVNGQQLTANTPANLKSGDNVTFGV-----FESKFSVEHQKPVVCSSCLDNDGKTSLTQALLAVGGKLVNTWTQDCTHLVMPTAKVTIKTICALLCCRPIVKPEF---FSELGKAAQQKLPPPKAESFIPEIDEPSLSKEDVNLGAIPVRKQLFAGKTFIFLSAKQLKRLSAAVGFGGGRSQLLEEGSLPRDVLESPQSCVIDATTGSSQPLLSSSTTEWANTVKNIVQRKGLRVIAESEIGLAAIYASCDQYCNPSRLITDSESLPKVNPR 327
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A1S3K6I0 (nibrin OS=Lingula unguis OX=7574 GN=LOC106179244 PE=4 SV=1) HSP 1 Score: 151.754 bits (382), Expect = 6.986e-35 Identity = 102/308 (33.12%), Postives = 164/308 (53.25%), Query Frame = 1 Query: 118 IGRVSADVILTH-TSISRKHAVLIWECDLNYI---------TIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIH----NPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDS--DCRDQSLRVK---LAHCDSIVMQEAVTTN---LVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYR 975 IGR D+++ S+SRKHAV I N++ TI D SKFGTF+N + I + +KDGD + FGAQ + F + S L N+ + +K + +GG++L + + + +VMS + T KVVCALI Q IV +++ +++ + N+ LP+PD ++P + NPD+ + +K NP R+ LF+ +F FL+ ++ LS AV GG +L+ + D D+ L + + +C+ + ++ N V + LK +R I D+E+GFAV+ S D YCNP R Sbjct: 23 IGRKDCDILIEGDQSMSRKHAVAIVVHPENHLPFPHKPPVLTIKDTSKFGTFVNGS-RIQGERELKDGDEIKFGAQSSFRVKRE--PFIVTTSCLDNSVKKSVKGVIRQLGGHVLGDWRRECDMLVMSTISVTIKVVCALISQKPIVTPEYLTQLLEAYDQ-NKQLPNPDDFIPALAELLLNPDE----VSFKKNPARQTLFSGMKFIFLSPKQFRKLSIAVELAGGTPVLMEEGTDDNNDKVLIERGTCVMYCEPPTNPQLLSKNARDWVTHVQRYLKRHKQRQIQDAELGFAVLYCSTDSYCNPER 322
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A4W6BPE5 (FHA domain-containing protein OS=Lates calcarifer OX=8187 GN=nbn PE=4 SV=1) HSP 1 Score: 149.828 bits (377), Expect = 4.060e-34 Identity = 110/323 (34.06%), Postives = 158/323 (48.92%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLI-NKKGNIKDGDIVTFGAQPGVDLNCSFVA---FDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILP--DPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDC-RD-----QSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPK 1017 Y L Y +GR + D++LT+ SISR HA L +T+ D SK+GTF+N L N N+K GD VTFGA N F +VCS+ L N + L Q L +GG L+ + ++ M ++K T K + AL+ IVK +F + + Q LP P+ ++PEI P ++ K P RK LF K F FL+ ++L LS AV G G + LL + RD QS V + S + + T+ N + I++ R+I +SEIG A + AS D+YCNP +P S P+ Sbjct: 15 YLLARKEYVVGRKNCDILLTNDQSISRAHAHLT--ATDQILTLKDTSKYGTFVNSQRLTDNTPVNLKSGDSVTFGA-----FNSKFSVDHQKPVVCSSCLDNDGKASLSQALLALGGKLVNTWTEDCTHLAMPSVKVTIKTISALLCCRPIVKPEF---FSELHNAVQQKLPPPKPESFIPEIDEPSLSKEDVNLKVIPGRKHLFTEKTFIFLSAKQLKRLSAAVSFGRGKSQLLEEGSLPRDLLESPQSCVVDVMTGSSQPLLSSSATDWANSVKNIVERKGLRVIPESEIGLAAIYASCDKYCNPSSVMPDSESAPKVKPR 327
BLAST of FHA domain-containing protein vs. TrEMBL
Match: A0A4W6BIH3 (FHA domain-containing protein OS=Lates calcarifer OX=8187 GN=nbn PE=4 SV=1) HSP 1 Score: 149.443 bits (376), Expect = 5.644e-34 Identity = 110/323 (34.06%), Postives = 158/323 (48.92%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLI-NKKGNIKDGDIVTFGAQPGVDLNCSFVA---FDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILP--DPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDC-RD-----QSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPK 1017 Y L Y +GR + D++LT+ SISR HA L +T+ D SK+GTF+N L N N+K GD VTFGA N F +VCS+ L N + L Q L +GG L+ + ++ M ++K T K + AL+ IVK +F + + Q LP P+ ++PEI P ++ K P RK LF K F FL+ ++L LS AV G G + LL + RD QS V + S + + T+ N + I++ R+I +SEIG A + AS D+YCNP +P S P+ Sbjct: 15 YLLARKEYVVGRKNCDILLTNDQSISRAHAHLT--ATDQILTLKDTSKYGTFVNSQRLTDNTPVNLKSGDSVTFGA-----FNSKFSVDHQKPVVCSSCLDNDGKASLSQALLALGGKLVNTWTEDCTHLAMPSVKVTIKTISALLCCRPIVKPEF---FSELHNAVQQKLPPPKPESFIPEIDEPSLSKEDVNLKVIPGRKHLFTEKTFIFLSAKQLKRLSAAVSFGRGKSQLLEEGSLPRDLLESPQSCVVDVMTGSSQPLLSSSATDWANSVKNIVERKGLRVIPESEIGLAAIYASCDKYCNPSSVMPDSESAPKVKPR 327
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: nbn (nibrin [Source:NCBI gene;Acc:103021427]) HSP 1 Score: 147.517 bits (371), Expect = 7.017e-37 Identity = 95/303 (31.35%), Postives = 149/303 (49.17%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLI-NKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLR------VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNP 969 Y LP Y +GR + D++L + SISR HA L +T+ D SK+GTF+N L N + DGD +TFG Q L + + +VCS+ + N + L + + +GG L+ + + ++VM +K T K +CAL+ IVK +F + + ++LP ++ PEI P +D P P+RK LF +K F FL +++ LS+A+ GGG+ LL + L+ + + S + T V+ + +L R I +SEIG A + S YCNP Sbjct: 15 YLLPGKEYVVGRKNCDILLANDQSISRVHAQLT--VADQTVTLKDSSKYGTFVNDEQLTTNSTKTVHDGDRLTFGVFQSKFRLKLNSM---VVCSSCVDNEGKAALSKAVQSVGGRLVNSWSPDCTHLVMPTVKVTIKTICALLCCRPIVKAEFFTELSRAVQRKEKVLPAAQNFKPEIDEPSLTKQDVDLGPRPERKSLFRDKTFVFLNVKQMKRLSQAITCGGGVTQLLEEGSLPLPLLQSTGTCVIDVGAGASQALVPPATKKWVDSVGQVLHRNGLRFIAESEIGLAAIYVSNQTYCNP 312
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Match: nbn (nibrin [Source:NCBI gene;Acc:103021427]) HSP 1 Score: 147.517 bits (371), Expect = 7.928e-37 Identity = 95/303 (31.35%), Postives = 149/303 (49.17%), Query Frame = 1 Query: 91 YFLPSVTYTIGRVSADVILTH-TSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLI-NKKGNIKDGDIVTFGA-QPGVDLNCSFVAFDIVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLR------VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNP 969 Y LP Y +GR + D++L + SISR HA L +T+ D SK+GTF+N L N + DGD +TFG Q L + + +VCS+ + N + L + + +GG L+ + + ++VM +K T K +CAL+ IVK +F + + ++LP ++ PEI P +D P P+RK LF +K F FL +++ LS+A+ GGG+ LL + L+ + + S + T V+ + +L R I +SEIG A + S YCNP Sbjct: 15 YLLPGKEYVVGRKNCDILLANDQSISRVHAQLT--VADQTVTLKDSSKYGTFVNDEQLTTNSTKTVHDGDRLTFGVFQSKFRLKLNSM---VVCSSCVDNEGKAALSKAVQSVGGRLVNSWSPDCTHLVMPTVKVTIKTICALLCCRPIVKAEFFTELSRAVQRKEKVLPAAQNFKPEIDEPSLTKQDVDLGPRPERKSLFRDKTFVFLNVKQMKRLSQAITCGGGVTQLLEEGSLPLPLLQSTGTCVIDVGAGASQALVPPATKKWVDSVGQVLHRNGLRFIAESEIGLAAIYVSNQTYCNP 312
BLAST of FHA domain-containing protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004190.1 (pep scaffold:Pmarinus_7.0:GL476745:100200:113784:1 gene:ENSPMAG00000003821.1 transcript:ENSPMAT00000004190.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 110.923 bits (276), Expect = 1.227e-26 Identity = 92/319 (28.84%), Postives = 149/319 (46.71%), Query Frame = 1 Query: 112 YTIGRVSADVILTH-TSISRKHAVLI---WECDLN------YITIDDCSKFGTFINKAPLIN-KKGNIKDGDIVTFGAQPGVDLNCSFVAFD--IVCSTLSNAD-RVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDH--YLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNL------------VNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALP 984 + +GR +++ + SISR HAVL E L +++ D SK+GTF+N L + + + GD++ FG V + VA+ +VCS+ +A+ + +L L +GG+ + ++VM+++K T K +CALI I IV+ F +V + + P P H + P P LD P P+R+ LF K F FL ++ L+ + GG A+ L R + R A C +V EA + L ++ + L + R+I ++E+G AV+ S YCNP LP Sbjct: 29 HVVGRKDCGILIGNDQSISRVHAVLTVSHAESSLARPSCRPALSVKDSSKYGTFVNGEKLTSGSERALCCGDLLKFG----VFESKYRVAYSPLVVCSSCLDAESKHVLSSALLALGGHFVSQWTSDCTHLVMTSIKVTVKTICALITSIPIVQPVFFSTLVTAIRSRS---PQPSHSSFWPLADEPGINPGDLDLTPRPERRLLFQGKTFQFLHAKQHKRLAVPIALAGGAALCLCSPGQRAEP-RHGEAFC--VVEPEAGCSQLSSQVLAQDARAWAAQVGVRLHTLGLRMITEAEVGLAVVYCSTHTYCNPSARLP 337
BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Match: EDO41630 (Nibrin [Source:UniProtKB/TrEMBL;Acc:A7S415]) HSP 1 Score: 120.168 bits (300), Expect = 2.443e-28 Identity = 98/330 (29.70%), Postives = 154/330 (46.67%), Query Frame = 1 Query: 58 KFENKNKNIVKYFLPSVTYTIGRVSADVIL-THTSISRKHAVLIW---------ECDLNYITIDDCSKFGTFINKAPLINKKG-NIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLL-ENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEA--------VTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNP-YRALP 984 K ++ N+ V+ F+ Y +GR +++ SISRKHAV L +T+ D SK+G +N L + + +GD++ FG S++ S L + +LK+ + +GG+LL E D ++VM L T KV+ AL IV +FV M+ + N+ L D +YLP I G + PNP RK LF+ K F FL++++ EAV GG L +DC S + ++C ++M +A T + + +LK R I +SE+G A++ S+ YCNP A+P Sbjct: 10 KAQDINQGTVR-FIVDKEYVVGRKDCQILINGDPSISRKHAVFTIGFNISDLGDTSKLPEVTVRDTSKYGVSVNGTKLESGGSCQLANGDVILFGTH-NSSYRLSYIQTVFATSCLDTNKKKILKKQIHKLGGHLLSEWRRDCTTHLVMEGLTFTVKVIQALASCCPIVTPEFVDEMIKSSEE-NRPLQDYRNYLPPIKEETIKSDGEKFLPNPDRKSLFSGKNFVFLSKKQYKRTFEAVEQCGGRTSLYESADCLVDSENLVASNC-CVMMVDAKERESLAPATRQFIGQAMDVLKRHRMRPIPESELGLAILQVSLSTYCNPNMEAVP 335
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Match: nbn (nibrin [Source:NCBI gene;Acc:101172437]) HSP 1 Score: 116.316 bits (290), Expect = 1.059e-26 Identity = 93/311 (29.90%), Postives = 141/311 (45.34%), Query Frame = 1 Query: 70 KNKNIVKYFLPSVTYTIGRVSADVIL-THTSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFD---IVCST-LSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLR------VKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNP 969 +N Y Y +GR + ++L + SISR HA L +T+ D SK+GTF+ + N+ GD VTFG + F +VCS+ L N + L + L +GG L+ + + ++ M +K T K + AL+ IVK +F + + + P P+ + PEI P ++ RK LF K F FL ++L LS AV GGG + LL + L+ V + S ++ A T N + +L R+I +SEIG A + AS D+YCNP Sbjct: 8 ENGGETHYIFCGKEYVVGRKNCAILLPSDQSISRAHANLT--ATDQTLTLKDSSKYGTFVRNQ-RVTSPVNLTPGDEVTFGV-----FHSKFRVIHQKLVVCSSCLDNDGKASLTEALLALGGKLVNSWSLDCTHLAMPTVKVTIKTISALLCCCPIVKPEFFSELNSAVQQ-KRPPPKPESFNPEIDEPVLSDENVNLGAVSARKQLFRGKTFIFLNAKQLKRLSGAVRFGGGSSQLLEEGALPCNLLQSPNTCVVDILTASSQILLPASITEWANSVKNLLARKGLRVIPESEIGLAAIYASCDQYCNP 309
BLAST of FHA domain-containing protein vs. Planmine SMEST
Match: SMESG000022990.1 (SMESG000022990.1) HSP 1 Score: 1141.33 bits (2951), Expect = 0.000e+0 Identity = 577/581 (99.31%), Postives = 577/581 (99.31%), Query Frame = 1 Query: 49 MPWKFENKNKNIVKYFLPSVTYTIGRVSADVILTHTSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPKQNPFPSLDKLPCKEEPSTNHPNKQVHNNSLGELRAHDINAIDFXXXXXXXXXXXXXXXXXXXNSNAHQHSLRRNQENNSPKPNLSVSKFFNLSTTNLPTMKRKFAMHSHDEFNNDFDNISIPGLQRIPANTLILEPTSRTIFSNFQDEEQNAHNIFPKKRKMNNTTDRSVSSCKIQNMSQTTKLVTDKQLFDLQLIREIPTRIQINPANEMDIRSCMENVKFAQLIKEKYIERKNYKMFIKSSPIYIERNSVPLVQFR 1791 MPWK ENKNKNIVKYFLPSVTYTIGRVSADVILTHTSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPKQNPFPSLDKLPCKEEPSTNHPNKQVHNNSLGELRAHDINAIDFDRDRDQIITISDTDSESDTNSNAHQHSLRRNQENNSPKPNLSVSKFFNLSTTNLPTMKRKFAMHSHDEFNNDFDNISIPGLQRIPANTLILE TSRTIFSNFQDEEQNAHNIFPKKRKMNNTTDRSVSSCKIQNMSQTTKLVTDKQLFDLQLIREIPTRIQINPANEMDIRSC ENVKFAQLIKEKYIE KNYKMFIKSSPIYIERNSVPLVQFR Sbjct: 1 MPWKLENKNKNIVKYFLPSVTYTIGRVSADVILTHTSISRKHAVLIWECDLNYITIDDCSKFGTFINKAPLINKKGNIKDGDIVTFGAQPGVDLNCSFVAFDIVCSTLSNADRVLLKQYLSIIGGNLLENCNDKVEYMVMSNLKATFKVVCALIKQIKIVKIDFVKAMVDYFKGINQILPDPDHYLPEIHNPDDCFIGLDYKPNPKRKCLFNNKQFYFLTQEKLSLLSEAVLSGGGIAMLLTDSDCRDQSLRVKLAHCDSIVMQEAVTTNLVNEISLILKGINKRLINDSEIGFAVMLASVDEYCNPYRALPKSHDKENNNPKQNPFPSLDKLPCKEEPSTNHPNKQVHNNSLGELRAHDINAIDFDRDRDQIITISDTDSESDTNSNAHQHSLRRNQENNSPKPNLSVSKFFNLSTTNLPTMKRKFAMHSHDEFNNDFDNISIPGLQRIPANTLILESTSRTIFSNFQDEEQNAHNIFPKKRKMNNTTDRSVSSCKIQNMSQTTKLVTDKQLFDLQLIREIPTRIQINPANEMDIRSCTENVKFAQLIKEKYIECKNYKMFIKSSPIYIERNSVPLVQFR 581 The following BLAST results are available for this feature:
BLAST of FHA domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 3
BLAST of FHA domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 0
BLAST of FHA domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of FHA domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of FHA domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 4
BLAST of FHA domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of FHA domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of FHA domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of FHA domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 2
BLAST of FHA domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of FHA domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of FHA domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 1
BLAST of FHA domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 1
BLAST of FHA domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 1
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019275 ID=SMED30019275|Name=FHA domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1810bpback to top protein sequence of SMED30019275-orf-1 >SMED30019275-orf-1 ID=SMED30019275-orf-1|Name=SMED30019275-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=582bp MPWKFENKNKNIVKYFLPSVTYTIGRVSADVILTHTSISRKHAVLIWECDback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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