E3 SUMO-protein ligase PIAS2

Overview


Name	E3 SUMO-protein ligase PIAS2
Smed ID	SMED30019208
Length (bp)	3747

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of E3 SUMO-protein ligase PIAS2 (SMED30019208) t-SNE clustered cells

Violin plots show distribution of expression levels for E3 SUMO-protein ligase PIAS2 (SMED30019208) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of E3 SUMO-protein ligase PIAS2 (SMED30019208) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for E3 SUMO-protein ligase PIAS2 (SMED30019208) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019208

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 2

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication	Specimen	Lifecycle	Evidence
X1 cell	SMED30019208	SMESG000070635.1	SmedASXL_017710	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015
X2 cell	SMED30019208	SMESG000070635.1	SmedASXL_017710	SmedAsxl_ww_GCZZ01	PMID:26114597 Zhu et al., 2015

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Match: PIAS2 (protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311])

HSP 1 Score: 109.383 bits (272), Expect = 7.105e-24
Identity = 93/337 (27.60%), Postives = 155/337 (45.99%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVEN-PMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V + P  + E+S          V ++AS + V D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKV-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Match: PIAS2 (protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311])

HSP 1 Score: 109.768 bits (273), Expect = 7.802e-24
Identity = 93/337 (27.60%), Postives = 155/337 (45.99%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVEN-PMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V + P  + E+S          V ++AS + V D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKV-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Match: PIAS2 (protein inhibitor of activated STAT 2 [Source:HGNC Symbol;Acc:HGNC:17311])

HSP 1 Score: 108.612 bits (270), Expect = 1.078e-23
Identity = 93/337 (27.60%), Postives = 155/337 (45.99%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVEN-PMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V + P  + E+S          V ++AS + V D+I L     SDEEED
Sbjct:  210 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKV-DVIDLTIESSSDEEED 512

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Match: PIAS3 (protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861])

HSP 1 Score: 104.375 bits (259), Expect = 4.296e-22
Identity = 86/347 (24.78%), Postives = 146/347 (42.07%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ--------------DLIVLDSDEEEDVVSTIQKPSV 1605
              F +T + V+ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P        ++     PVQ              DL +  S +EED+  T +  SV
Sbjct:  160 FTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFME---DGSWCPMKPKKEASEVCPP----PGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSV 470

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Match: PIAS3 (protein inhibitor of activated STAT 3 [Source:HGNC Symbol;Acc:HGNC:16861])

HSP 1 Score: 103.605 bits (257), Expect = 6.002e-22
Identity = 86/347 (24.78%), Postives = 146/347 (42.07%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ--------------DLIVLDSDEEEDVVSTIQKPSV 1605
              F +T + V+ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P        ++     PVQ              DL +  S +EED+  T +  SV
Sbjct:  125 FTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFME---DGSWCPMKPKKEASEVCPP----PGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSV 435

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Celegans
Match: gei-17 (E3 SUMO-protein ligase gei-17 [Source:UniProtKB/Swiss-Prot;Acc:Q94361])

HSP 1 Score: 76.6406 bits (187), Expect = 7.215e-14
Identity = 54/211 (25.59%), Postives = 98/211 (46.45%), Query Frame = 1

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ 1455
            L +V+P+N    E +R  +P+ IT  +    +      +  V++ W     +   +  GVY   +++   +      N +  +R ++     V  K       S  +DD    +  + L I+L  P+ K+R+  P R   C HLQCFD + +L MNE++  W+CP+C      + L  D +FL +L   K D+  ++V +  D S+  + +
Sbjct:  256 LPNVIPTNKTNAEPKRPSRPVNITSNMNRYKK------EHTVAVEWLADKRV---WAAGVYFVHRVNSDILFKRLNQN-VSRHRSLEVTKQEVIKKL------SGGEDD----IAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLA--KVDKNTTEVELKEDGSYDVIKE 444

[Close]

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ 1455
            L +V+P+N    E +R  +P+ IT  +    +      +  V++ W     +   +  GVY   +++   +      N +  +R ++     V  K       S  +DD    +  + L I+L  P+ K+R+  P R   C HLQCFD + +L MNE++  W+CP+C      + L  D +FL +L   K D+  ++V +  D S+  + +
Sbjct:  256 LPNVIPTNKTNAEPKRPSRPVNITSNMNRYKK------EHTVAVEWLADKRV---WAAGVYFVHRVNSDILFKRLNQN-VSRHRSLEVTKQEVIKKL------SGGEDD----IAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLA--KVDKNTTEVELKEDGSYDVIKE 444

[Close]

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ 1455
            L +V+P+N    E +R  +P+ IT  +    +      +  V++ W     +   +  GVY   +++   +      N +  +R ++     V  K       S  +DD    +  + L I+L  P+ K+R+  P R   C HLQCFD + +L MNE++  W+CP+C      + L  D +FL +L   K D+  ++V +  D S+  + +
Sbjct:  256 LPNVIPTNKTNAEPKRPSRPVNITSNMNRYKK------EHTVAVEWLADKRV---WAAGVYFVHRVNSDILFKRLNQN-VSRHRSLEVTKQEVIKKL------SGGEDD----IAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLA--KVDKNTTEVELKEDGSYDVIKE 444

[Close]

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ 1455
            L +V+P+N    E +R  +P+ IT  +    +      +  V++ W     +   +  GVY   +++   +      N +  +R ++     V  K       S  +DD    +  + L I+L  P+ K+R+  P R   C HLQCFD + +L MNE++  W+CP+C      + L  D +FL +L   K D+  ++V +  D S+  + +
Sbjct:  256 LPNVIPTNKTNAEPKRPSRPVNITSNMNRYKK------EHTVAVEWLADKRV---WAAGVYFVHRVNSDILFKRLNQN-VSRHRSLEVTKQEVIKKL------SGGEDD----IAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLA--KVDKNTTEVELKEDGSYDVIKE 444

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Celegans
Match: gei-17 (E3 SUMO-protein ligase gei-17 [Source:UniProtKB/Swiss-Prot;Acc:Q94361])

HSP 1 Score: 76.6406 bits (187), Expect = 7.533e-14
Identity = 54/211 (25.59%), Postives = 98/211 (46.45%), Query Frame = 1

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ 1455
            L +V+P+N    E +R  +P+ IT  +    +      +  V++ W     +   +  GVY   +++   +      N +  +R ++     V  K       S  +DD    +  + L I+L  P+ K+R+  P R   C HLQCFD + +L MNE++  W+CP+C      + L  D +FL +L   K D+  ++V +  D S+  + +
Sbjct:  189 LPNVIPTNKTNAEPKRPSRPVNITSNMNRYKK------EHTVAVEWLADKRV---WAAGVYFVHRVNSDILFKRLNQN-VSRHRSLEVTKQEVIKKL------SGGEDD----IAMDRLNISLLDPLCKTRMTTPSRCQDCTHLQCFDLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLA--KVDKNTTEVELKEDGSYDVIKE 377

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Match: Su(var)2-10 (gene:FBgn0003612 transcript:FBtr0343996)

HSP 1 Score: 122.094 bits (305), Expect = 3.514e-28
Identity = 88/345 (25.51%), Postives = 165/345 (47.83%), Query Frame = 1

Query:  553 LLNYMQAPNFVVRVNTTQ----PLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKE-VFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEE 1569
            +L  +  P+ +V  NT +    P  F +T +    + SN   + + K+E+  QV LRF  ++ +  +E  F              +++ VN     L +V+P+N    E +R P+P+ +T  +KL+    N      +++ W   P+ T  + + VYL +K++  +++       +   +P D     ++ K  +       D DC+  + + +L ++LNCP+ K ++ +P R   C HLQCFDA  +L MNER+  W CP+CD+ A  ++L  D +F  +L       + +++ ++ D S+              P  R+E  +++  S +P Q + V+  D E
Sbjct:  182 VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPN-----------VNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTN-----TITVQW--CPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGV---KPADYTRGLIKEKLTE-------DADCE--IATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSW------------STPGLRSETQILDTPS-KPAQKVEVISDDIE 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Match: Su(var)2-10 (gene:FBgn0003612 transcript:FBtr0088571)

HSP 1 Score: 121.709 bits (304), Expect = 3.669e-28
Identity = 91/355 (25.63%), Postives = 170/355 (47.89%), Query Frame = 1

Query:  553 LLNYMQAPNFVVRVNTTQ----PLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKE-VFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKP 1599
            +L  +  P+ +V  NT +    P  F +T +    + SN   + + K+E+  QV LRF  ++ +  +E  F              +++ VN     L +V+P+N    E +R P+P+ +T  +KL+    N      +++ W   P+ T  + + VYL +K++  +++       +   +P D     ++ K  +       D DC+  + + +L ++LNCP+ K ++ +P R   C HLQCFDA  +L MNER+  W CP+CD+ A  ++L  D +F  +L       + +++ ++ D S+              P  R+E  +++  S +P Q + V+  D E  ++S   KP
Sbjct:  182 VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPN-----------VNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTN-----TITVQW--CPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGV---KPADYTRGLIKEKLTE-------DADCE--IATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSW------------STPGLRSETQILDTPS-KPAQKVEVISDDIE--LISDDAKP 491

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Match: Su(var)2-10 (gene:FBgn0003612 transcript:FBtr0088570)

HSP 1 Score: 122.479 bits (306), Expect = 3.678e-28
Identity = 91/355 (25.63%), Postives = 170/355 (47.89%), Query Frame = 1

Query:  553 LLNYMQAPNFVVRVNTTQ----PLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKE-VFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKP 1599
            +L  +  P+ +V  NT +    P  F +T +    + SN   + + K+E+  QV LRF  ++ +  +E  F              +++ VN     L +V+P+N    E +R P+P+ +T  +KL+    N      +++ W   P+ T  + + VYL +K++  +++       +   +P D     ++ K  +       D DC+  + + +L ++LNCP+ K ++ +P R   C HLQCFDA  +L MNER+  W CP+CD+ A  ++L  D +F  +L       + +++ ++ D S+              P  R+E  +++  S +P Q + V+  D E  ++S   KP
Sbjct:  182 VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPN-----------VNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTN-----TITVQW--CPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGV---KPADYTRGLIKEKLTE-------DADCE--IATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSW------------STPGLRSETQILDTPS-KPAQKVEVISDDIE--LISDDAKP 491

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Match: Su(var)2-10 (gene:FBgn0003612 transcript:FBtr0306705)

HSP 1 Score: 121.709 bits (304), Expect = 4.626e-28
Identity = 91/355 (25.63%), Postives = 170/355 (47.89%), Query Frame = 1

Query:  553 LLNYMQAPNFVVRVNTTQ----PLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKE-VFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKP 1599
            +L  +  P+ +V  NT +    P  F +T +    + SN   + + K+E+  QV LRF  ++ +  +E  F              +++ VN     L +V+P+N    E +R P+P+ +T  +KL+    N      +++ W   P+ T  + + VYL +K++  +++       +   +P D     ++ K  +       D DC+  + + +L ++LNCP+ K ++ +P R   C HLQCFDA  +L MNER+  W CP+CD+ A  ++L  D +F  +L       + +++ ++ D S+              P  R+E  +++  S +P Q + V+  D E  ++S   KP
Sbjct:  182 VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPN-----------VNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTN-----TITVQW--CPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGV---KPADYTRGLIKEKLTE-------DADCE--IATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSW------------STPGLRSETQILDTPS-KPAQKVEVISDDIE--LISDDAKP 491

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Match: Su(var)2-10 (gene:FBgn0003612 transcript:FBtr0088576)

HSP 1 Score: 120.939 bits (302), Expect = 4.870e-28
Identity = 91/355 (25.63%), Postives = 170/355 (47.89%), Query Frame = 1

Query:  553 LLNYMQAPNFVVRVNTTQ----PLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKE-VFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKP 1599
            +L  +  P+ +V  NT +    P  F +T +    + SN   + + K+E+  QV LRF  ++ +  +E  F              +++ VN     L +V+P+N    E +R P+P+ +T  +KL+    N      +++ W   P+ T  + + VYL +K++  +++       +   +P D     ++ K  +       D DC+  + + +L ++LNCP+ K ++ +P R   C HLQCFDA  +L MNER+  W CP+CD+ A  ++L  D +F  +L       + +++ ++ D S+              P  R+E  +++  S +P Q + V+  D E  ++S   KP
Sbjct:  135 VLGTLIKPSTLVPRNTQRVQEVPFYFTLTPQQATEIASNRDIRNSSKVEHAIQVQLRFCLVETSCDQEDCFPPN-----------VNVKVNNKLCQLPNVIPTNRPNVEPKRPPRPVNVTSNVKLSPTVTNT-----ITVQW--CPDYTRSYCLAVYLVKKLTSTQLLQRMKTKGV---KPADYTRGLIKEKLTE-------DADCE--IATTMLKVSLNCPLGKMKMLLPCRASTCSHLQCFDASLYLQMNERKPTWNCPVCDKPAIYDNLVIDGYFQEVLGSSLLKSDDTEIQLHQDGSW------------STPGLRSETQILDTPS-KPAQKVEVISDDIE--LISDDAKP 444

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Match: pias2 (protein inhibitor of activated STAT, 2 [Source:ZFIN;Acc:ZDB-GENE-060424-1])

HSP 1 Score: 109.768 bits (273), Expect = 4.596e-24
Identity = 87/335 (25.97%), Postives = 155/335 (46.27%), Query Frame = 1

Query:  583 VVRVNTTQPLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVENP--------MPRNENSVVNQASTQPVQDLIVLD 1557
            V R +  +   F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N    Q+V +TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++AT   L  D  F+ IL    ND  +V ++    D ++  +   ++  ++ +P        +P  +++VV+   T   +   V+D
Sbjct:  160 VQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPN----QIV-VTW--APEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEIL----NDCTDVDEIQFQEDGTWCPMRPKKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVID 461

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Match: pias2 (protein inhibitor of activated STAT, 2 [Source:ZFIN;Acc:ZDB-GENE-060424-1])

HSP 1 Score: 109.768 bits (273), Expect = 4.618e-24
Identity = 87/335 (25.97%), Postives = 155/335 (46.27%), Query Frame = 1

Query:  583 VVRVNTTQPLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVENP--------MPRNENSVVNQASTQPVQDLIVLD 1557
            V R +  +   F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N    Q+V +TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++AT   L  D  F+ IL    ND  +V ++    D ++  +   ++  ++ +P        +P  +++VV+   T   +   V+D
Sbjct:  160 VQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPN----QIV-VTW--APEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEIL----NDCTDVDEIQFQEDGTWCPMRPKKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVID 461

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Match: pias2 (protein inhibitor of activated STAT, 2 [Source:ZFIN;Acc:ZDB-GENE-060424-1])

HSP 1 Score: 109.768 bits (273), Expect = 5.143e-24
Identity = 87/335 (25.97%), Postives = 155/335 (46.27%), Query Frame = 1

Query:  583 VVRVNTTQPLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVENP--------MPRNENSVVNQASTQPVQDLIVLD 1557
            V R +  +   F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N    Q+V +TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++AT   L  D  F+ IL    ND  +V ++    D ++  +   ++  ++ +P        +P  +++VV+   T   +   V+D
Sbjct:  169 VQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPN----QIV-VTW--APEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEIL----NDCTDVDEIQFQEDGTWCPMRPKKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVID 470

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Match: pias2 (protein inhibitor of activated STAT, 2 [Source:ZFIN;Acc:ZDB-GENE-060424-1])

HSP 1 Score: 109.768 bits (273), Expect = 5.234e-24
Identity = 87/335 (25.97%), Postives = 155/335 (46.27%), Query Frame = 1

Query:  583 VVRVNTTQPLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVENP--------MPRNENSVVNQASTQPVQDLIVLD 1557
            V R +  +   F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N    Q+V +TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++AT   L  D  F+ IL    ND  +V ++    D ++  +   ++  ++ +P        +P  +++VV+   T   +   V+D
Sbjct:  169 VQRFHNEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLAETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEQKRPGRPLNITSLVRLSSAVPN----QIV-VTW--APEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEIL----NDCTDVDEIQFQEDGTWCPMRPKKETLKLSSPCISKIDCSVPVRQSAVVSVPETSSTKKADVID 470

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Match: pias4a (protein inhibitor of activated STAT, 4a [Source:NCBI gene;Acc:406712])

HSP 1 Score: 98.5969 bits (244), Expect = 9.363e-21
Identity = 65/212 (30.66%), Postives = 104/212 (49.06%), Query Frame = 1

Query:  838 PSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQ 1473
            PSN    E RR  +P+ IT  L L+T          V++TW    +    + V VYL R  +  E+ +     S+ N    D     +++K    P +          + +  L ++L CP+ K R+G+P R + C HLQCFDAVFFL MNE++  W CP+CD+ A    L  D     IL+  +  E+V ++    D S+  +  ++++E+
Sbjct:  216 PSNKPGVEPRRPCRPVNITPWLHLST------VTNRVTITWGNFGK---RYSVAVYLVRVFTSGELFNQLKHCSVENP---DRCRERIQDKLRFDPESE---------IATTGLRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQMNEKKPTWTCPVCDKPAPFELLTIDGLLSEILK--ETPEDVEEIEYLTDGSWRPIRDDKEKER 404

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Match: pias3 (protein inhibitor of activated STAT 3 [Source:NCBI gene;Acc:100144644])

HSP 1 Score: 108.997 bits (271), Expect = 1.187e-23
Identity = 87/344 (25.29%), Postives = 147/344 (42.73%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQP-------------VQDLIVLDSDEEEDVVSTIQKP 1599
             NF +T + V  ++S+       K +Y  QV LRF   + +  +E +  P           + + VN+   PL   LP      E +R  +PI IT  ++L +   N      + + W    E    + + VYL ++++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R I C HLQCFDA  +L MNE++  W CP+CD++A  + L  D  F+ IL    + +E+  +    D S+  +   ++++ +  P P          S  P             V DL +  S +EE+  S  Q P
Sbjct:  157 FNFALTPQQVHQILSSRDILPGAKCDYTVQVQLRFCLCETSCPQEDYFPPN----------LFVKVNQKLCPLPGYLPPTKNGAEPKRPNRPINITPLIRLTSTVPN-----TIVVNWSS--EFGRNYSLSVYLVKQLTSVTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAITCTHLQCFDAALYLQMNEKKPTWTCPVCDKKAPYDMLIIDGLFMDILNSCTDCDEIQFME---DGSWCPMRPKKEKQDICQPSPYGGIEASGIYSMTPELKHSAEAKKKVEVIDLTLDSSSDEEEPPSKKQCP 468

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Match: pias3 (protein inhibitor of activated STAT 3 [Source:NCBI gene;Acc:100144644])

HSP 1 Score: 108.997 bits (271), Expect = 1.197e-23
Identity = 87/344 (25.29%), Postives = 147/344 (42.73%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQP-------------VQDLIVLDSDEEEDVVSTIQKP 1599
             NF +T + V  ++S+       K +Y  QV LRF   + +  +E +  P           + + VN+   PL   LP      E +R  +PI IT  ++L +   N      + + W    E    + + VYL ++++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R I C HLQCFDA  +L MNE++  W CP+CD++A  + L  D  F+ IL    + +E+  +    D S+  +   ++++ +  P P          S  P             V DL +  S +EE+  S  Q P
Sbjct:  157 FNFALTPQQVHQILSSRDILPGAKCDYTVQVQLRFCLCETSCPQEDYFPPN----------LFVKVNQKLCPLPGYLPPTKNGAEPKRPNRPINITPLIRLTSTVPN-----TIVVNWSS--EFGRNYSLSVYLVKQLTSVTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAITCTHLQCFDAALYLQMNEKKPTWTCPVCDKKAPYDMLIIDGLFMDILNSCTDCDEIQFME---DGSWCPMRPKKEKQDICQPSPYGGIEASGIYSMTPELKHSAEAKKKVEVIDLTLDSSSDEEEPPSKKQCP 468

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Match: pias3 (protein inhibitor of activated STAT 3 [Source:NCBI gene;Acc:100144644])

HSP 1 Score: 108.227 bits (269), Expect = 1.778e-23
Identity = 86/335 (25.67%), Postives = 149/335 (44.48%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRN--ENSV-----VNQASTQPVQDLIVLD------SDEEE 1572
             NF +T + V  ++S+       K +Y  QV LRF   + +  +E +  P           + + VN+   PL   LP      E +R  +PI IT  ++L +   N      + + W    E    + + VYL ++++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R I C HLQCFDA  +L MNE++  W CP+CD++A  + L  D  F+ IL    + +E+  +    D S+  +   ++++ +  P P    E  +     V + S +  + + V+D      SDEEE
Sbjct:  122 FNFALTPQQVHQILSSRDILPGAKCDYTVQVQLRFCLCETSCPQEDYFPPN----------LFVKVNQKLCPLPGYLPPTKNGAEPKRPNRPINITPLIRLTSTVPN-----TIVVNWSS--EFGRNYSLSVYLVKQLTSVTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAITCTHLQCFDAALYLQMNEKKPTWTCPVCDKKAPYDMLIIDGLFMDILNSCTDCDEIQFME---DGSWCPMRPKKEKQDICQPSPYGGIEGELGGWYRVGRHSAEAKKKVEVIDLTLDSSSDEEE 424

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Match: rgs11 (regulator of G-protein signaling 11 [Source:Xenbase;Acc:XB-GENE-5761563])

HSP 1 Score: 104.375 bits (259), Expect = 3.768e-22
Identity = 73/265 (27.55%), Postives = 123/265 (46.42%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            F +T + VR ++ +  Y   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL           E +R  +P+ IT  ++L++   N      VS++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A+   L  D  F+ IL    + +E+
Sbjct:  171 FALTPQQVREVVISRDYMPGGRRDYSVQVQLRLCLAETSCPQE----------DNYPSSLCIKVNGKLFPLPGCAVPPKNGVEQKRPGRPLNITSLVRLSSAVPNQ-----VSISWAS--EIGKNYSMSVYLVRQLTSAVLLQKLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKASYESLIIDGLFMEILNQCSDVDEI 406

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Match: PIAS1 (protein inhibitor of activated STAT 1 [Source:NCBI gene;Acc:100488714])

HSP 1 Score: 97.8265 bits (242), Expect = 4.167e-20
Identity = 76/287 (26.48%), Postives = 130/287 (45.30%), Query Frame = 1

Query:  616 FIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQV 1476
            F +T      IS++      K ++  QV LRF   + +  +E          ++ PP + + VN     L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   F + VYL +++S   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R++ C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL   K   +  ++    D S+  +   ++ ++V
Sbjct:  170 FALTPQQVQQISSSMDISGTKCDFTVQVQLRFCLSETSCPQE----------DHFPPNLCVKVNGKPCNLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPNT-----IVVSWTA--EIGRNFSLAVYLVKQLSSAILLQRLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLTIPCRSLTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEIL---KCCTDCDEIQFKEDGSWSPMRSKKEVQEV 424

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Match: Pias2 (protein inhibitor of activated STAT 2 [Source:MGI Symbol;Acc:MGI:1096566])

HSP 1 Score: 108.227 bits (269), Expect = 1.271e-23
Identity = 92/337 (27.30%), Postives = 153/337 (45.40%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQV-ENPMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V   P  + E+S          V + AS + + D+I L     SDEEED
Sbjct:  174 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKI-DVIDLTIESSSDEEED 476

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Match: Pias2 (protein inhibitor of activated STAT 2 [Source:MGI Symbol;Acc:MGI:1096566])

HSP 1 Score: 108.227 bits (269), Expect = 1.409e-23
Identity = 92/337 (27.30%), Postives = 153/337 (45.40%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQV-ENPMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V   P  + E+S          V + AS + + D+I L     SDEEED
Sbjct:  174 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKI-DVIDLTIESSSDEEED 476

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Match: Pias2 (protein inhibitor of activated STAT 2 [Source:MGI Symbol;Acc:MGI:1096566])

HSP 1 Score: 108.227 bits (269), Expect = 1.779e-23
Identity = 92/337 (27.30%), Postives = 153/337 (45.40%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQV-ENPMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V   P  + E+S          V + AS + + D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKI-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Match: Pias3 (protein inhibitor of activated STAT 3 [Source:MGI Symbol;Acc:MGI:1913126])

HSP 1 Score: 105.531 bits (262), Expect = 1.263e-22
Identity = 82/337 (24.33%), Postives = 144/337 (42.73%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ----------DLIVLDSDEEEDVVST 1587
              F +T + ++ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P     + +   A  + +Q          DL +  S +EED+  T
Sbjct:  151 FTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFME---DGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPT 455

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Match: Pias3 (protein inhibitor of activated STAT 3 [Source:MGI Symbol;Acc:MGI:1913126])

HSP 1 Score: 105.145 bits (261), Expect = 1.468e-22
Identity = 82/337 (24.33%), Postives = 144/337 (42.73%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ----------DLIVLDSDEEEDVVST 1587
              F +T + ++ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P     + +   A  + +Q          DL +  S +EED+  T
Sbjct:  160 FTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFME---DGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPT 464

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Match: sp|O75928|PIAS2_HUMAN (E3 SUMO-protein ligase PIAS2 OS=Homo sapiens OX=9606 GN=PIAS2 PE=1 SV=3)

HSP 1 Score: 109.768 bits (273), Expect = 3.747e-23
Identity = 93/337 (27.60%), Postives = 155/337 (45.99%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVEN-PMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V + P  + E+S          V ++AS + V D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKV-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Match: sp|Q6AZ28|PIAS2_RAT (E3 SUMO-protein ligase PIAS2 OS=Rattus norvegicus OX=10116 GN=Pias2 PE=1 SV=1)

HSP 1 Score: 108.227 bits (269), Expect = 8.336e-23
Identity = 92/337 (27.30%), Postives = 153/337 (45.40%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQV-ENPMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V   P  + E+S          V + AS + + D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKI-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Match: sp|Q8C5D8|PIAS2_MOUSE (E3 SUMO-protein ligase PIAS2 OS=Mus musculus OX=10090 GN=Pias2 PE=1 SV=2)

HSP 1 Score: 108.227 bits (269), Expect = 1.245e-22
Identity = 92/337 (27.30%), Postives = 153/337 (45.40%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQV-ENPMPRNENS----------VVNQASTQPVQDLIVL----DSDEEED 1575
            F +T + VR +  +  +   G+ +Y  QV LR    + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S++W    EI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  +L MNE++  W CP+CD++A    L  D  F+ IL    ND  +V ++    D S+  +   ++  +V   P  + E+S          V + AS + + D+I L     SDEEED
Sbjct:  181 FALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQ-----ISISWAS--EIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEIL----NDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKI-DVIDLTIESSSDEEED 483

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Match: sp|O54714|PIAS3_MOUSE (E3 SUMO-protein ligase PIAS3 OS=Mus musculus OX=10090 GN=Pias3 PE=1 SV=3)

HSP 1 Score: 105.145 bits (261), Expect = 1.027e-21
Identity = 82/337 (24.33%), Postives = 144/337 (42.73%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ----------DLIVLDSDEEEDVVST 1587
              F +T + ++ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P     + +   A  + +Q          DL +  S +EED+  T
Sbjct:  160 FTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFME---DGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPT 464

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Match: sp|Q9Y6X2|PIAS3_HUMAN (E3 SUMO-protein ligase PIAS3 OS=Homo sapiens OX=9606 GN=PIAS3 PE=1 SV=2)

HSP 1 Score: 104.375 bits (259), Expect = 2.063e-21
Identity = 86/347 (24.78%), Postives = 146/347 (42.07%), Query Frame = 1

Query:  610 LNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQ--------------DLIVLDSDEEEDVVSTIQKPSV 1605
              F +T + V+ ++++ +     K +Y  QV LRF   + +  +E +  P           + + VN    PL   LP      E +R  +PI IT   +L+    N      + + W    E    + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQ FDA  +L MNE++  W CP+CD++A    L  D  F+ IL    + +E+  +    D S+  +   ++  +V  P        ++     PVQ              DL +  S +EED+  T +  SV
Sbjct:  160 FTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPN----------LFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPN-----TIVVNWSS--EFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILSSCSDCDEIQFME---DGSWCPMKPKKEASEVCPP----PGYGLDGLQYSPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSV 470

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Match: A0A068WE72 (E3 SUMO protein ligase PIAS2 OS=Echinococcus granulosus OX=6210 GN=EgrG_000941500 PE=4 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 1.129e-29
Identity = 84/294 (28.57%), Postives = 152/294 (51.70%), Query Frame = 1

Query:  610 LNFIITENVRNLISNNQYKVNG-KIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXX--------YMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSL-----YAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAV 1449
            L+F I  +    I+ + ++++G + ++  QVL+RF  ++ +   EV A       E            ++++ VN     L  +LP+     +GRR+ +P+ IT  L+++   +N      V ++W        Y +  +YL +K S +E+        Y P  +   + +D++ + V +  G + N   ++ D DDL I N LP+ L CP+SK RI +P+R  RC+H+QC+DA  +L +NER+  WKCP+CD  A  ++LF D   + IL   +  ++V ++  N + S+  +
Sbjct:  226 LDFRINSDQAETITYHSHRLDGNRRDFGVQVLMRFGKLEPSLLPEVVAASTPDSSEPALAPFADSMPIHLNIFVNVKQAMLPPLLPTCRPNMDGRRYARPVNITPLLRVSPSVSNH-----VKLSWSHDYSTFSYNFFAIYLVQKHSTKELCEALRTHAYRPALVVQRQIVDKLASTVTSCGGGSDNEVMDESDDDDLQIQNTLPVQLLCPLSKCRIKLPVRGQRCQHIQCYDADTYLLINERKPAWKCPVCDSLAPFHELFVDGLLMDILA-TRESQDVEEIVFNENGSWTTM 513

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Match: A0A068YA98 (E3 SUMO protein ligase PIAS2 OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000941500 PE=4 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 1.170e-29
Identity = 85/294 (28.91%), Postives = 155/294 (52.72%), Query Frame = 1

Query:  610 LNFIITENVRNLISNNQYKVNG-KIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXX--------XXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSL-----YAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAV 1449
            L+F I  +    I+ + ++++G + ++  QVL+RF  ++ +   EV A       E        ++P ++++ VN     L  +LP+     +GRR+ +P+ IT  L+++   +N      V ++W        Y +  +YL +K S +E+        Y P  +   + +D++ + V +  G + N   ++ D DDL I N LP+ L CP+SK RI +P+R  RC+H+QC+DA  +L +NER+  WKCP+CD  A  ++LF D   + IL   +  ++V ++  N + S+  +
Sbjct:  226 LDFRINSDQAETITYHSHRLDGNRRDFGVQVLMRFGKLEPSLLPEVVAASTPDSSEPVLAPFADSMPIHLNIFVNVKQAMLPPLLPTCRPNMDGRRYARPVNITPLLRVSPAVSNH-----VKLSWSHDYSTFSYNFFAIYLVQKHSTKELCEALRTHAYRPAPVVQRQIVDKLASTVTSCGGGSGNGVVDESDDDDLQIQNTLPVQLLCPLSKCRIKLPVRGQRCQHIQCYDADTYLLINERKPAWKCPVCDSPAPFHELFVDGLLMDILA-TRESQDVEEIVFNENGSWTTM 513

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Match: A0A183RN87 (Uncharacterized protein OS=Schistosoma rodhaini OX=6188 PE=4 SV=1)

HSP 1 Score: 134.035 bits (336), Expect = 2.960e-29
Identity = 92/304 (30.26%), Postives = 144/304 (47.37%), Query Frame = 1

Query:  676 KIEYKWQVLLRFVGID------VTQAKEVFAXXXXXXXXXXXXY----------MSLIVNEISHP--LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMD-EILAWVRNKFGKAPNNS-----------------QNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVE 1479
            ++E+  QV++RF  +D      + QA E++ +       +              + LI+     P  L  +LPSN    +GRR+P+PI IT  L ++    N      + +TW        Y  VG+YL R+ S +++  L    S  N   M  EI+  +      +PN +                 +N DD DDLV+ N LP+ L CP+SK RI +P+R   C H+QC+DA  +L +NER+  W CP+CD +A   DL  D  FL IL   K  +++ ++  + D S+ A+ +     Q E
Sbjct:   43 RMEFGVQVIMRFARLDPQACQDLVQAYELYGSRKSSSLSSDKLIQIPLAEDSLPVHLIIQVNGRPIQLPPLLPSNRPGMDGRRNPRPINITQSLHVSPTVPN-----YIKLTWTHDYSSYTYNVVGIYLMRRRSPQQLCGLLHSTSFQNANVMKMEIMKKL------SPNATTGNISSVNSQSQSSACNENGDDDDDLVMPNTLPVQLLCPLSKCRIEVPVRGRNCRHVQCYDATTYLIINERKPTWNCPVCDGKAVYEDLIVDGLFLEILNS-KRSQDLEEIIFHSDGSWSALGEEMTSNQSE 334

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Match: A0A0R3SHI3 (Uncharacterized protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS4396 PE=4 SV=1)

HSP 1 Score: 137.117 bits (344), Expect = 8.329e-29
Identity = 81/278 (29.14%), Postives = 147/278 (52.88%), Query Frame = 1

Query:  622 ITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXX--XXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAV 1449
            +  N    I+ + Y V  + E++ Q L+RF  ++ +    + A+ P +    +N+P ++++ VN+ +  L   LP++    +GRR+ +PI IT +L++       G   L+ ++W        Y++  VYL +++S +E+      N     RP + +   +  K   +     + +D DD+ I N LP+ L CP+SK RI +P+R  RC+H+QC+DA  +  +NER+  WKCP+CD  A  ++LF D   + IL+  K  +   ++  N D S+  +
Sbjct:  214 LDANQSETITYHSYNVGNRREFRVQALVRFGKLEPSMLHRITASQPTLEPFQDNMPIHLAVQVNQRNVILPPFLPTSRPNMDGRRNARPISITPQLRMCP-----GAVNLIKLSWSHDYTSFTYYFFAVYLVKRLSTKELCDFLKTNCY---RPGNFVRKQIIAKLASSGLPLNDGEDDDDIQIQNTLPVQLLCPLSKCRINLPVRGKRCQHIQCYDADTYFIINERKPAWKCPVCDLLAPFDELFVDGLLMEILES-KKSQNAEEIVFNEDGSWTTM 482

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Match: A0A0R3X776 (Uncharacterized protein OS=Hydatigena taeniaeformis OX=6205 GN=TTAC_LOCUS9381 PE=4 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 1.229e-28
Identity = 86/295 (29.15%), Postives = 150/295 (50.85%), Query Frame = 1

Query:  610 LNFIITENVRNLISNNQYKVNG-KIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXX--------YMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSL-----YAPNSLFNNRPMDEILAWVRN-KFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAV 1449
            L+F I  +    I+ + ++++G + ++  QVL+RF  ++ +   EV A        +           ++++ VN     L  +LP+     +GRR+ +PI IT  L+++   +N      V ++W        Y +  +YL +K S +E+        Y    +   + +D++ + V +   G      +  DD DDL I N LP+ L CP+SK RI +P+R  RC+H+QC+DA  +L +NER+  WKCP+CD  A  ++LF D   L+IL   K  ++V ++  N D S+  +
Sbjct:  187 LDFRINSDQAETITYHSHRLDGNRRDFGVQVLMRFGKLEPSLLSEVVAASTSDSKRSTLAPFVDSMPIHLNIFVNVKQATLPPLLPTCRPNMDGRRYARPINITPLLRVSPSVSNH-----VKLSWSHDYSTFSYNFFAIYLVQKHSTKELCEALRTHAYRSAQVVQKQIVDKLASTVTSCSVGSGGGMVEESDD-DDLQIQNTLPVQLLCPLSKCRIKLPVRGQRCQHIQCYDADTYLLINERKPAWKCPVCDILAPFHELFVDGLLLNILAS-KESQDVEEIVFNEDGSWTTM 474

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Match: pias2 (protein inhibitor of activated STAT, 2 [Source:ZFIN;Acc:ZDB-GENE-060424-1])

HSP 1 Score: 114.39 bits (285), Expect = 1.344e-25
Identity = 87/328 (26.52%), Postives = 154/328 (46.95%), Query Frame = 1

Query:  571 APNFVVRVNTTQPLNFIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKND-EEVSDVNVNPDNSFVAVTQNRDREQVENP-MPRNENSV-VNQASTQPVQD 1542
             P+ V R +  +   F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S+TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++AT   L  D  F+ IL    ND  +V ++    D ++  +   ++  +V +P +P+ E +  V Q++  P  +
Sbjct:  161 GPSTVQRFHQEKYFIFALTPQQVREVCISRDFLPGGRRDYMVQIQLRFCLSETSCPQE----------DNYPNSLCIKVNGKLFPLPGYAPPPKNGVEQKRPGRPLNITSLVRLSSAVPNQ-----ISVTW--APEIGKTYSMSVYLVRQLTSPLLLQRLRMKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKATYESLIIDGLFMEIL----NDCTDVDEIKFQEDGTWCPMRPKKEALKVSSPIIPKIECAAPVRQSAVVPYSE 455

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Match: pias1b (protein inhibitor of activated STAT, 1b [Source:ZFIN;Acc:ZDB-GENE-050419-202])

HSP 1 Score: 94.7449 bits (234), Expect = 2.090e-19
Identity = 73/264 (27.65%), Postives = 119/264 (45.08%), Query Frame = 1

Query:  616 FIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            F +T      IS++      K ++  QV LRF   + +  +E          ++ PP + + VN     L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   + + VYL R+ S   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E+
Sbjct:  165 FALTPQQVQQISSSMDISGTKCDFAVQVQLRFCLSETSCPQE----------DHFPPNLCVKVNGKPCNLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSYSMAVYLVRQQSSSVLLQRLRSKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLMIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILNSCVDCDEI 399

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Match: pias1b (protein inhibitor of activated STAT, 1b [Source:ZFIN;Acc:ZDB-GENE-050419-202])

HSP 1 Score: 94.7449 bits (234), Expect = 2.286e-19
Identity = 57/191 (29.84%), Postives = 91/191 (47.64%), Query Frame = 1

Query:  835 LPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            LP      E +R  +PI IT  ++L+T   N      + ++W    EI   + + VYL R+ S   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E+
Sbjct:  231 LPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSYSMAVYLVRQQSSSVLLQRLRSKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLMIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILNSCVDCDEI 402

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Match: pias1b (protein inhibitor of activated STAT, 1b [Source:ZFIN;Acc:ZDB-GENE-050419-202])

HSP 1 Score: 93.2041 bits (230), Expect = 3.326e-19
Identity = 57/191 (29.84%), Postives = 91/191 (47.64%), Query Frame = 1

Query:  835 LPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            LP      E +R  +PI IT  ++L+T   N      + ++W    EI   + + VYL R+ S   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E+
Sbjct:  202 LPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSYSMAVYLVRQQSSSVLLQRLRSKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLMIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILNSCVDCDEI 373

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Match: pias1a (protein inhibitor of activated STAT, 1a [Source:ZFIN;Acc:ZDB-GENE-120727-5])

HSP 1 Score: 93.9745 bits (232), Expect = 3.855e-19
Identity = 59/218 (27.06%), Postives = 101/218 (46.33%), Query Frame = 1

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQV 1476
            L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   + + VYL ++ +   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E   +    D S+  +   ++ ++V
Sbjct:  233 LPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSYSMAVYLVKQQTSTALLQRLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLMIPCRAVTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILNSCVDCDE---IQFKEDGSWAPMRSKKEVQEV 428

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006097.1 (pep scaffold:Pmarinus_7.0:GL477570:42904:66158:-1 gene:ENSPMAG00000005462.1 transcript:ENSPMAT00000006097.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 96.6709 bits (239), Expect = 5.488e-21
Identity = 63/242 (26.03%), Postives = 114/242 (47.11%), Query Frame = 1

Query:  802 VNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVEN-PMPRNENSVVNQAS 1524
            VN    PL   LP      E +R  +PI IT  ++L+    N      ++++W    +    + + VYL ++++   +++      + N+   D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A  + L  D  F+ IL    +  +V ++    D S+  +   ++ + V N P  R  ++  +  S
Sbjct:  244 VNGKLCPLPGYLPPTKNGVEPKRPSRPINITAYVRLSPTVPNH-----ITVSW--TADFGRNYSISVYLVKQLTSSLLLNRMKAKGIRNS---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLTIPCRALTCTHLQCFDAALYIQMNEKKPTWVCPVCDKKAPYDSLIIDGLFMEILS---SCTDVDEIKFREDGSWSPMRPKKECQDVTNRPFARTGSNSYDNGS 463

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001340.1 (pep scaffold:Pmarinus_7.0:GL476352:326724:335624:-1 gene:ENSPMAG00000001204.1 transcript:ENSPMAT00000001340.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 87.8113 bits (216), Expect = 3.517e-18
Identity = 41/140 (29.29%), Postives = 73/140 (52.14%), Query Frame = 1

Query:  988 FYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            + + V+L +++S   +++      + N+   D   A ++ K    P         D  + +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++A  + L  D  F+ IL    + +E+
Sbjct:  280 YSLAVHLVKQLSSAVLLNRLKAKGIRNS---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLSLPCRALTCTHLQCFDAALYLQMNEKKPTWVCPVCDKKAPYDGLIIDGLFVEILNSCTDADEI 407

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Yeast
Match: NFI1 (SUMO E3 ligase; catalyzes sumoylation of Yku70p/80p and Sir4p promoting telomere anchoring to the nuclear envelope and regulating telomerase activity; DNA-bound form catalyzes a DNA-damaged triggered sumoylation wave resulting in multisite modification of several DNA repair proteins, enhancing interactions between these proteins and accelerating repair; sumoylates Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; role in telomere length maintenance [Source:SGD;Acc:S000005682])

HSP 1 Score: 76.2554 bits (186), Expect = 2.110e-14
Identity = 44/148 (29.73%), Postives = 80/148 (54.05%), Query Frame = 1

Query:  991 YVGVYLERKISVREMMSLYAPNSLFNN---RPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVN 1425
            Y+ +  E  IS   ++ +++P +L      RP  +I+      + K   N Q+DDD    +I+    ++L CP+S +R+  P +T +C+H+QCFDA++FL    +   W+CPIC      + L   +F  +I+Q+   D E  +++V+
Sbjct:  274 YLNIDKEYSISCF-IVEVFSPEALLGKILKRP--KIIKQATTAYIKRTLNEQDDDD----IITTSTVLSLQCPISCTRMKYPAKTDQCKHIQCFDALWFLHSQSQVPTWQCPICQHPIKFDQLKISEFVDNIIQNCNEDVEQVEISVD 414

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Yeast
Match: SIZ1 (SUMO E3 ligase; promotes attachment of small ubiquitin-related modifier sumo (Smt3p) to primarily cytoplasmic proteins; regulates Rsp5p ubiquitin ligase activity and is in turn itself regulated by Rsp5p; required for sumoylation of septins and histone H3 variant Cse4p, a prerequisite for STUbL-mediated Ub-dependent degradation; localizes to the septin ring; acts as an adapter between E2, Ubc9p and substrates; tends to compensate for survival of DNA damage in absence of Nfi1p [Source:SGD;Acc:S000002817])

HSP 1 Score: 70.8626 bits (172), Expect = 9.506e-13
Identity = 41/137 (29.93%), Postives = 73/137 (53.28%), Query Frame = 1

Query: 1183 INLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQ----NRDREQVENPMPRNENSVVNQ--ASTQPVQDLIV-LDSDEEE 1572
            ++L CP+S +R+  P ++I C+HLQCFDA++FL    +   W+CP+C       +L   +F   ILQ+ + +  V  V +  D  + A+ +    +       +  P    SV +   +S+ P + +I+ LDSD++E
Sbjct:  357 MSLQCPISYTRMKYPSKSINCKHLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNCQKN--VEQVELTSDGKWTAILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDDDE 491

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Nematostella
Match: EDO32140 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SVX5])

HSP 1 Score: 83.5741 bits (205), Expect = 7.450e-17
Identity = 34/78 (43.59%), Postives = 49/78 (62.82%), Query Frame = 1

Query: 1147 DCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSIL 1380
            D D  V +  L + L CP+ KS++ +P R++ C HLQCFDA  +L MNE+++ W CP+CD++A    L  D  F  IL
Sbjct:  277 DPDSEVATTSLRVTLLCPLGKSKMTLPCRSVTCSHLQCFDAALYLQMNEKKTTWICPVCDQKAEFKSLVLDGLFREIL 354

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Nematostella
Match: EDO40709 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S6F2])

HSP 1 Score: 63.1586 bits (152), Expect = 4.142e-11
Identity = 32/94 (34.04%), Postives = 48/94 (51.06%), Query Frame = 1

Query: 1057 SLFNNR--PMDEILAWVRNKFG---KAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPIC 1323
            SL   R  P +  +  V+  F     AP  + +DD  +   I     ++L CP++  RI +P R   C+H+QCFD   +L +N  R  WKCP+C
Sbjct:  107 SLLRKRLLPAEHCITKVKRNFSLCSTAPTTNGSDDGVEQTAIK----VSLKCPITFRRISLPARGHDCKHIQCFDLESYLRLNCERGSWKCPVC 196

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Match: pias2 (E3 SUMO-protein ligase PIAS2 [Source:NCBI gene;Acc:101155036])

HSP 1 Score: 108.227 bits (269), Expect = 7.839e-24
Identity = 75/265 (28.30%), Postives = 125/265 (47.17%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S+TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++A   +L  D  FL IL    + +E+
Sbjct:   90 FALTPQQVREVCISRDFLPGGRRDYLVQIQLRFCLSETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEPKRPGRPLNITSLVRLSSAVPNQ-----ISVTW--APEIGKTYSMSVYLVRQLTSPLLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKAAYENLIIDGLFLEILNDCSDVDEI 325

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Match: pias2 (E3 SUMO-protein ligase PIAS2 [Source:NCBI gene;Acc:101155036])

HSP 1 Score: 107.457 bits (267), Expect = 1.390e-23
Identity = 75/265 (28.30%), Postives = 125/265 (47.17%), Query Frame = 1

Query:  616 FIIT-ENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEV 1407
            F +T + VR +  +  +   G+ +Y  Q+ LRF   + +  +E          +N P  + + VN    PL    P      E +R  +P+ IT  ++L++   N      +S+TW   PEI   + + VYL R+++   ++       + N    D   A ++ K    P         D  V +  L ++L CP+ K R+ +P R + C HLQCFDA  +L MNE++  W CP+CD++A   +L  D  FL IL    + +E+
Sbjct:   81 FALTPQQVREVCISRDFLPGGRRDYLVQIQLRFCLSETSCPQE----------DNYPNGLCIKVNGKLFPLPGFAPPPKNGVEPKRPGRPLNITSLVRLSSAVPNQ-----ISVTW--APEIGKTYSMSVYLVRQLTSPLLLQRLKMKGIRNP---DHSRALIKEKLTADP---------DSEVATTSLRVSLMCPLGKMRLTVPCRAVTCSHLQCFDAALYLQMNEKKPTWICPVCDKKAAYENLIIDGLFLEILNDCSDVDEI 316

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Match: pias1b (E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc:101160651])

HSP 1 Score: 97.0561 bits (240), Expect = 4.129e-20
Identity = 70/264 (26.52%), Postives = 121/264 (45.83%), Query Frame = 1

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQ-------VENPMPRNENSVVNQASTQPVQDLIVLD------SDEEED 1575
            L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   F + VYL R+ S   ++       + N    D   A ++ K    P +          + +  L ++L CP+ K R+ IP R+  C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E   +    D S+  +   ++ ++       V++ + R E +   + S+   + + V+D      S+EE+D
Sbjct:  217 LPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSFSMAVYLVRQQSSAVLLQRLRAKGIRNP---DHSRALIKEKLTADPESE---------IATTSLRVSLLCPLGKMRLTIPCRSATCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILSSCSDCDE---IQFKEDGSWAPMRSKKEVQEVSASYNGVDSDVSRTEANEQKRGSSHDNKKVDVIDLTLDSSSEEEQD 458

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Match: pias1b (E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc:101160651])

HSP 1 Score: 96.6709 bits (239), Expect = 5.834e-20
Identity = 61/218 (27.98%), Postives = 101/218 (46.33%), Query Frame = 1

Query:  823 LWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQV 1476
            L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   F + VYL R+ S   ++       + N    D   A ++ K    P +          + +  L ++L CP+ K R+ IP R+  C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E   +    D S+  +   ++ ++V
Sbjct:  226 LPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRSFSMAVYLVRQQSSAVLLQRLRAKGIRNP---DHSRALIKEKLTADPESE---------IATTSLRVSLLCPLGKMRLTIPCRSATCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILSSCSDCDE---IQFKEDGSWAPMRSKKEVQEV 421

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Match: pias1a (E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc:101169428])

HSP 1 Score: 93.2041 bits (230), Expect = 4.915e-19
Identity = 75/289 (25.95%), Postives = 129/289 (44.64%), Query Frame = 1

Query:  616 FIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVEN 1482
            F +T      IS++      K ++  QV LRF   + +  +E          ++ PP + + VN     L   LP      E +R  +PI IT  ++L+T   N      + ++W    EI   + + VYL ++ S   ++       + N    D   A ++ K    P         D  + +  L ++L CP+ K R+ IP R + C HLQCFDA  ++ MNE++  W CP+CD++A    L  D  F+ IL    + +E   +    D S+  +   ++ ++V +
Sbjct:  184 FALTPQQVQQISSSMDISGTKCDFSVQVQLRFCLSETSCPQE----------DHFPPNLCVKVNGKPCTLPGYLPPTKNGVEPKRPSRPINITSLVRLSTTVPN-----TIVVSWTS--EIGRNYSMAVYLVKQQSSTVLLQRLRAKGIRNP---DHSRALIKEKLTADP---------DSEIATTSLRVSLLCPLGKMRLMIPCRALTCSHLQCFDATLYIQMNEKKPTWVCPVCDKKAPYEHLIIDGLFVEILNSCMDCDE---IQFKEDGSWAPMRSKKEVQEVSS 440

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Match: SMESG000070635.1 (SMESG000070635.1)

HSP 1 Score: 1558.89 bits (4035), Expect = 0.000e+0
Identity = 922/933 (98.82%), Postives = 926/933 (99.25%), Query Frame = 1

Query:  565 MQAPNFVVRVNTTQPLNFIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKPSVEIQQSNQLSTGLPKLLSAPTSHXXXXXXXXXXXXXSSIHKSTPVRESAVPSVPPPYATPLASLKPVDTNLQDSATKVXXXXXXXXXXXXXXXRRTQSNATEVRTTKSIVTTPSERSTNSSTSNIF-SVTQXXXXXXXXXXXXXXXXXXXXXXXXFVSNSPVSLNAFPPQQFPGKPASSFMGCAISSTIAPIAXXXXXXXXXXXXXXXXXXPATVPSAFGNPISVISSRTLSDKNPNSIIPPRKSPIXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXADIQSRNSSWKSRSEVQISSANLQPPSTMTGVIGEVSTKDIVDDIVRTLPVTNIPDVPTKKRTADHSPEPINCPNIIVHQPDKKNDTPAKTPDQIKKLDNQKRLKTFQSKIPPPSSNVTIPSLTIDLTAEDDEEQQTSVNIKQAVPLAQKSMTWVPVSGPISNNLNKMINGINMTKFPTNHLNRSATNNRNIENEKRKLAELGIGHYKPHQMLHSNFSVKSPKAHIDLTADDDDEDRIPNKRPRFGNSDNXXXXXXXXXXXLGSDINTADEEDGQINDNESTASNNSSNVKGAHNKNALHVVSKRKL 3360
            MQAPNFVVRVNTTQPLNFIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFANPPEIFPENIPPYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNA+GGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKPSVEIQQSNQLSTGLPKLLSAPTSHTPKQVQPPPKTTPSSIHKSTPVRESAVPSVPPPYATPLASLKPVDTNLQDSATKVTSSSTDSQSISNQTNRRTQSN TEVRTTKSIVTTPSERSTNSSTSNIF SVTQTPISSIISSIVPPPITNNPILIPPFVSNSPVSLNAFPPQQFPGKPASSFMGCAISSTIAPIA STLSNSVLNSVNLSKSVPATVPSAFGNPISVISSR LSDK+ NSIIPPRKSPITTSVQNNTT+TTSKE LISNSSSKSLISSISTSADIQSRNSSWKSRSEVQISSANLQPP+TMTGVIGEV TKDIVDDIVRTLPVTNIPDVPTKKRTADHSPEPINCPNIIVHQPDKKNDTPAKTPDQIKKLDNQKRLKTFQSKIPPPSSNVTIPSLTIDLTAEDDEEQQTSVNIKQAVPLAQKSMTWVPVSGPISNNLNKMINGINMTKFPTNHLNRSATNNRNIENEKRKLAELGIGHYKPHQMLHSNFSVKSPKAHIDLTADDDDEDRIPNKRPRFGNSDNAAAATTAVATVLGSDINTADEEDGQINDNESTASNNSSNVKGAHNKNALHVVSKRKL
Sbjct:    1 MQAPNFVVRVNTTQPLNFIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFANPPEIFPENIPPYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNASGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQDLIVLDSDEEEDVVSTIQKPSVEIQQSNQLSTGLPKLLSAPTSHTPKQVQPPPKTTPSSIHKSTPVRESAVPSVPPPYATPLASLKPVDTNLQDSATKVTSSSTDSQSISNQTNRRTQSNVTEVRTTKSIVTTPSERSTNSSTSNIFSSVTQTPISSIISSIVPPPITNNPILIPPFVSNSPVSLNAFPPQQFPGKPASSFMGCAISSTIAPIASSTLSNSVLNSVNLSKSVPATVPSAFGNPISVISSRPLSDKHSNSIIPPRKSPITTSVQNNTTKTTSKEPLISNSSSKSLISSISTSADIQSRNSSWKSRSEVQISSANLQPPTTMTGVIGEVPTKDIVDDIVRTLPVTNIPDVPTKKRTADHSPEPINCPNIIVHQPDKKNDTPAKTPDQIKKLDNQKRLKTFQSKIPPPSSNVTIPSLTIDLTAEDDEEQQTSVNIKQAVPLAQKSMTWVPVSGPISNNLNKMINGINMTKFPTNHLNRSATNNRNIENEKRKLAELGIGHYKPHQMLHSNFSVKSPKAHIDLTADDDDEDRIPNKRPRFGNSDNAAAATTAVATVLGSDINTADEEDGQINDNESTASNNSSNVKGAHNKNALHVVSKRKL 933

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Match: SMESG000023854.1 (SMESG000023854.1)

HSP 1 Score: 308.916 bits (790), Expect = 3.933e-91
Identity = 182/439 (41.46%), Postives = 262/439 (59.68%), Query Frame = 1

Query:  361 LDEVPLNLRTDLSNPI-----------ITPQMEXXXXXXXXXXXXXXVDYPNILL-----NKKVITSPFHCCQVCLQPLTLLNYMQAPNFV--VRVNTTQPLNFIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFG------KAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDEEVSDVNVNPDNSF--VAVTQNRDREQ-VENPMPRNENSVVNQ-------ASTQPVQDLIVLDSDEEED 1575
            LD+ P+NLR ++ N I             P                 V+ PN+ L     N  + +S F+CCQV L PL+LL     PN V   R+ +   L F ++ + R+LI+ ++ ++N K  +KWQVL+RF   D T+     +      PE IPPY++L VN  + PLWD+LPSN   KEG+RHP+PI I+D LK ++ + + GY+Q +++ WWQ P +  Y+Y  VYLERK+SV E+   +   +     P+   L ++R KF       K  + S   DD DDLVIS+VLPI+L CPV KSRI  PLR + C+HLQCFDA  +L MNERRSVWKCP+CD  AT N+LF D+FFL ILQ F+ +E++++VNVNPD S+  VAV ++R+ +Q + N +   +NS VN+       + +   Q +I+L+SD+EE+
Sbjct:  137 LDKCPINLRPEIVNGIDPSNIFIPNYTKYPTGYFNAPSCSPSFVNGRVNMPNVQLPYCVKNTVISSSQFYCCQVVLHPLSLLIPKPTPNIVQTTRIMSKMQLQFTLSNSARHLITAHRSQLNNKRFFKWQVLVRFGVYDPTKPFPNSSENISNLPEYIPPYLTLFVNNATVPLWDILPSNSAAKEGKRHPRPINISDYLKFSSAD-DQGYRQTINVNWWQTPGVYQYYYFAVYLERKLSVSELFDRFINKTHHVQMPISFTLNFIREKFSTNNQYKKISDESTEMDDDDDLVISSVLPISLLCPVGKSRITCPLRGVYCQHLQCFDAHLYLMMNERRSVWKCPVCDSSATLNELFVDEFFLKILQDFQKNEDLTEVNVNPDGSYVPVAVKESREHKQHIGNIISNVDNSKVNEDENSTDSSDSTEKQPVILLESDDEEN 574

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Match: SMESG000058500.1 (SMESG000058500.1)

HSP 1 Score: 100.523 bits (249), Expect = 4.063e-21
Identity = 82/305 (26.89%), Postives = 135/305 (44.26%), Query Frame = 1

Query:  499 KVITSPFHCCQVCLQPLT------LLNYMQAPNFVVRVNTTQPLNFIITENVRNLISNNQYKVNGKIEYKWQVLLRFVGI-DVTQAKEVFAXXXXXXXXXXXXYMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFK 1392
            + + +PF+ C   + PLT      LL  ++   F+      Q L F +  +   L+S ++   + K + +   ++RF  I DV +  + F             ++ L +N     L   LP++   K+GRR P+P+ +++ L  N    N    Q     W Q       FY  VYL R+ +  E+  +     L    P+       +N   +  NN     D D +++ N +  +L CPVS+ R+  P+R   C HLQCFD V +L MN  +  W+CP+CD++     L  D   L IL   +
Sbjct:    5 RFVLTPFYECIDTIIPLTKLRLTNLLPDVKPGRFI----GNQLLEFSLQLDHSFLLSESKKHKSNKFDIR--AIIRFSNIEDVHKVDDQFTLKDVFPI-----HLKLNLNNTLITLPQFLPNDRTGKDGRRFPRPVDLSEGLLDNPLVINKFLIQ-----WVQDDCKKESFYFAVYLVRRRTCEELSQILMKKQL---SPIQN----TQNFIAEHSNNHNTGQDDDLMLVDNTINTSLICPVSRVRMSTPVRGQHCTHLQCFDCVTYLIMNFNKPTWQCPVCDKKTFFCYLEVDSLILGILNDLR 286

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Match: SMESG000069268.1 (SMESG000069268.1)

HSP 1 Score: 91.2781 bits (225), Expect = 4.366e-18
Identity = 66/206 (32.04%), Postives = 99/206 (48.06%), Query Frame = 1

Query:  787 YMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPI-NLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDE 1401
            ++ + VN     L D LP +++   GRR+ +PI ITD +  +       YK    + W Q    T + +    L+RK S  E+ S          +P+ EI        GK  +           +IS+ L I +L+CP S  R+G P+R   C HLQCFD V +L+MN  + +W+CPICD++   + L  D    +IL    NDE
Sbjct:   34 FLKISVNNCQIHLSDYLPFDNERTWGRRYARPIDITDAIVFDK-----DYKNHCVIKWGQEYCNTKFMFALFILKRK-STDELCSQIMK------KPVYEI--------GKNQS-----------LISSYLSITSLHCPASLCRMGFPVRGDTCTHLQCFDLVTYLTMNFLKPIWRCPICDKETPYHLLRVDSLIHNIL----NDE 204

[Close]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Match: SMESG000069268.1 (SMESG000069268.1)

HSP 1 Score: 90.8929 bits (224), Expect = 4.683e-18
Identity = 66/206 (32.04%), Postives = 99/206 (48.06%), Query Frame = 1

Query:  787 YMSLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQLVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEILAWVRNKFGKAPNNSQNDDDCDDLVISNVLPI-NLNCPVSKSRIGIPLRTIRCEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFKNDE 1401
            ++ + VN     L D LP +++   GRR+ +PI ITD +  +       YK    + W Q    T + +    L+RK S  E+ S          +P+ EI        GK  +           +IS+ L I +L+CP S  R+G P+R   C HLQCFD V +L+MN  + +W+CPICD++   + L  D    +IL    NDE
Sbjct:   85 FLKISVNNCQIHLSDYLPFDNERTWGRRYARPIDITDAIVFDK-----DYKNHCVIKWGQEYCNTKFMFALFILKRK-STDELCSQIMK------KPVYEI--------GKNQS-----------LISSYLSITSLHCPASLCRMGFPVRGDTCTHLQCFDLVTYLTMNFLKPIWRCPICDKETPYHLLRVDSLIHNIL----NDE 255

The following BLAST results are available for this feature:

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Celegans
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Sea Lamprey
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Yeast
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Nematostella
BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
PIAS2	7.105e-24	27.60	protein inhibitor of activated STAT 2 [Source:HGNC...	[more]
PIAS2	7.802e-24	27.60	protein inhibitor of activated STAT 2 [Source:HGNC...	[more]
PIAS2	1.078e-23	27.60	protein inhibitor of activated STAT 2 [Source:HGNC...	[more]
PIAS3	4.296e-22	24.78	protein inhibitor of activated STAT 3 [Source:HGNC...	[more]
PIAS3	6.002e-22	24.78	protein inhibitor of activated STAT 3 [Source:HGNC...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gei-17	7.215e-14	25.59	E3 SUMO-protein ligase gei-17 [Source:UniProtKB/S...	[more]
gei-17	7.215e-14	25.59	E3 SUMO-protein ligase gei-17 [Source:UniProtKB/S...	[more]
gei-17	7.215e-14	25.59	E3 SUMO-protein ligase gei-17 [Source:UniProtKB/S...	[more]
gei-17	7.215e-14	25.59	E3 SUMO-protein ligase gei-17 [Source:UniProtKB/S...	[more]
gei-17	7.533e-14	25.59	E3 SUMO-protein ligase gei-17 [Source:UniProtKB/S...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Su(var)2-10	3.514e-28	25.51	gene:FBgn0003612 transcript:FBtr0343996	[more]
Su(var)2-10	3.669e-28	25.63	gene:FBgn0003612 transcript:FBtr0088571	[more]
Su(var)2-10	3.678e-28	25.63	gene:FBgn0003612 transcript:FBtr0088570	[more]
Su(var)2-10	4.626e-28	25.63	gene:FBgn0003612 transcript:FBtr0306705	[more]
Su(var)2-10	4.870e-28	25.63	gene:FBgn0003612 transcript:FBtr0088576	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pias2	4.596e-24	25.97	protein inhibitor of activated STAT, 2 [Source:ZFI...	[more]
pias2	4.618e-24	25.97	protein inhibitor of activated STAT, 2 [Source:ZFI...	[more]
pias2	5.143e-24	25.97	protein inhibitor of activated STAT, 2 [Source:ZFI...	[more]
pias2	5.234e-24	25.97	protein inhibitor of activated STAT, 2 [Source:ZFI...	[more]
pias4a	9.363e-21	30.66	protein inhibitor of activated STAT, 4a [Source:NC...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pias3	1.187e-23	25.29	protein inhibitor of activated STAT 3 [Source:NCBI...	[more]
pias3	1.197e-23	25.29	protein inhibitor of activated STAT 3 [Source:NCBI...	[more]
pias3	1.778e-23	25.67	protein inhibitor of activated STAT 3 [Source:NCBI...	[more]
rgs11	3.768e-22	27.55	regulator of G-protein signaling 11 [Source:Xenbas...	[more]
PIAS1	4.167e-20	26.48	protein inhibitor of activated STAT 1 [Source:NCBI...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Pias2	1.271e-23	27.30	protein inhibitor of activated STAT 2 [Source:MGI ...	[more]
Pias2	1.409e-23	27.30	protein inhibitor of activated STAT 2 [Source:MGI ...	[more]
Pias2	1.779e-23	27.30	protein inhibitor of activated STAT 2 [Source:MGI ...	[more]
Pias3	1.263e-22	24.33	protein inhibitor of activated STAT 3 [Source:MGI ...	[more]
Pias3	1.468e-22	24.33	protein inhibitor of activated STAT 3 [Source:MGI ...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|O75928\|PIAS2_HUMAN	3.747e-23	27.60	E3 SUMO-protein ligase PIAS2 OS=Homo sapiens OX=96...	[more]
sp\|Q6AZ28\|PIAS2_RAT	8.336e-23	27.30	E3 SUMO-protein ligase PIAS2 OS=Rattus norvegicus ...	[more]
sp\|Q8C5D8\|PIAS2_MOUSE	1.245e-22	27.30	E3 SUMO-protein ligase PIAS2 OS=Mus musculus OX=10...	[more]
sp\|O54714\|PIAS3_MOUSE	1.027e-21	24.33	E3 SUMO-protein ligase PIAS3 OS=Mus musculus OX=10...	[more]
sp\|Q9Y6X2\|PIAS3_HUMAN	2.063e-21	24.78	E3 SUMO-protein ligase PIAS3 OS=Homo sapiens OX=96...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
A0A068WE72	1.129e-29	28.57	E3 SUMO protein ligase PIAS2 OS=Echinococcus granu...	[more]
A0A068YA98	1.170e-29	28.91	E3 SUMO protein ligase PIAS2 OS=Echinococcus multi...	[more]
A0A183RN87	2.960e-29	30.26	Uncharacterized protein OS=Schistosoma rodhaini OX...	[more]
A0A0R3SHI3	8.329e-29	29.14	Uncharacterized protein OS=Hymenolepis diminuta OX...	[more]
A0A0R3X776	1.229e-28	29.15	Uncharacterized protein OS=Hydatigena taeniaeformi...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pias2	1.344e-25	26.52	protein inhibitor of activated STAT, 2 [Source:ZFI...	[more]
pias1b	2.090e-19	27.65	protein inhibitor of activated STAT, 1b [Source:ZF...	[more]
pias1b	2.286e-19	29.84	protein inhibitor of activated STAT, 1b [Source:ZF...	[more]
pias1b	3.326e-19	29.84	protein inhibitor of activated STAT, 1b [Source:ZF...	[more]
pias1a	3.855e-19	27.06	protein inhibitor of activated STAT, 1a [Source:ZF...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000006097.1	5.488e-21	26.03	pep scaffold:Pmarinus_7.0:GL477570:42904:66158:-1 ...	[more]
ENSPMAT00000001340.1	3.517e-18	29.29	pep scaffold:Pmarinus_7.0:GL476352:326724:335624:-...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2


Match Name	E-value	Identity	Description
NFI1	2.110e-14	29.73	SUMO E3 ligase; catalyzes sumoylation of Yku70p/80...	[more]
SIZ1	9.506e-13	29.93	SUMO E3 ligase; promotes attachment of small ubiqu...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 2


Match Name	E-value	Identity	Description
EDO32140	7.450e-17	43.59	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO40709	4.142e-11	34.04	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
pias2	7.839e-24	28.30	E3 SUMO-protein ligase PIAS2 [Source:NCBI gene;Acc...	[more]
pias2	1.390e-23	28.30	E3 SUMO-protein ligase PIAS2 [Source:NCBI gene;Acc...	[more]
pias1b	4.129e-20	26.52	E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc...	[more]
pias1b	5.834e-20	27.98	E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc...	[more]
pias1a	4.915e-19	25.95	E3 SUMO-protein ligase PIAS1 [Source:NCBI gene;Acc...	[more]

BLAST of E3 SUMO-protein ligase PIAS2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000070635.1	0.000e+0	98.82	SMESG000070635.1	[more]
SMESG000023854.1	3.933e-91	41.46	SMESG000023854.1	[more]
SMESG000058500.1	4.063e-21	26.89	SMESG000058500.1	[more]
SMESG000069268.1	4.366e-18	32.04	SMESG000069268.1	[more]
SMESG000069268.1	4.683e-18	32.04	SMESG000069268.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019208 ID=SMED30019208|Name=E3 SUMO-protein ligase PIAS2|organism=Schmidtea mediterranea sexual|type=transcript|length=3747bp
GATATTCAAAAAAGTTCTTAAATATTTTGATTTGATATTAAAATGCGTTC
TGATGATTTACTTTTAAAACTTCAGAAAAATATAAGAATCAATCTTTCTC
AAAAACATTTAATAAATTTGTGCACATATTTTAACTTGCCGATTTCAGGA
CGAAAAAATCAGATTCAAGAAAAATTAATAAACTTTACAAATACTCAGAG
TCATGAAACTTTAAAATCTATGTCAAATAAAGCAGATGAATATTTAAGAT
TGTCTTCTTCAACTAGGCCTAGAAACACTACAACTATAAATCGTACTTCA
ATCAGAATAGTTCCAGAAGTGTTAACGGAATCTAAACTTCAAACTGCACT
TATAAATCTACTCGACGAGGTACCTTTAAATCTTAGAACAGATTTATCAA
ATCCAATAATTACTCCACAAATGGAATTAACAACTACTTTCCCCCCTAAA
CCAACTAAACTTCCATTTGTTGATTATCCTAACATATTGTTAAATAAAAA
AGTTATTACATCTCCGTTTCATTGTTGTCAAGTTTGCTTGCAACCACTTA
CTCTTCTTAATTATATGCAAGCTCCAAATTTTGTTGTTCGCGTAAACACT
ACGCAACCTCTCAATTTTATCATTACGGAAAATGTGAGAAATTTAATATC
AAACAATCAGTATAAGGTCAATGGGAAAATCGAATATAAATGGCAAGTTT
TACTACGTTTTGTCGGTATCGATGTGACCCAGGCCAAAGAAGTGTTTGCG
AATCCACCAGAAATATTCCCTGAAAATATACCACCATATATGTCATTGAT
CGTAAATGAAATATCCCATCCTTTGTGGGATGTATTGCCAAGTAATCACA
AATTAAAAGAAGGAAGACGGCATCCTAAGCCCATTCAGATAACGGATAAA
TTAAAACTAAATACTCGAAATGCTAATGGAGGTTATAAACAATTAGTGTC
AATGACCTGGTGGCAAATTCCAGAGATTACTCCTTATTTCTATGTTGGGG
TTTATTTAGAAAGGAAAATTTCTGTAAGGGAAATGATGTCATTGTATGCA
CCAAATAGTCTGTTTAATAATAGACCAATGGATGAAATTTTAGCTTGGGT
TCGAAATAAATTTGGAAAAGCACCAAATAATTCACAGAACGATGATGACT
GTGACGATTTGGTGATTTCAAACGTGCTGCCGATCAATTTGAATTGTCCA
GTTTCTAAAAGCCGGATTGGGATTCCATTGAGAACAATCCGCTGTGAACA
TTTGCAATGCTTTGATGCGGTTTTTTTCTTATCAATGAATGAACGTCGAT
CTGTTTGGAAATGTCCGATTTGTGACGAACAGGCGACTCCGAACGATTTG
TTCACCGATAAATTCTTTCTCAGCATTCTCCAACATTTCAAAAACGACGA
AGAAGTGTCCGATGTCAATGTCAATCCCGATAATTCCTTTGTTGCCGTCA
CACAGAATCGAGACCGAGAGCAGGTAGAAAATCCAATGCCGAGAAATGAA
AATTCAGTAGTGAATCAAGCCTCCACTCAACCGGTACAAGATTTAATCGT
TCTCGACAGCGATGAAGAAGAGGATGTTGTTTCTACTATACAAAAACCAT
CAGTTGAAATCCAGCAATCTAATCAATTGTCAACAGGGCTACCAAAACTA
TTGAGCGCCCCTACATCGCACACACCTAAGCAAGTTCAGCCACCACCCAA
GACAACCCCATCCTCTATTCATAAGTCAACACCAGTCAGAGAATCAGCTG
TTCCTTCTGTGCCACCACCGTACGCAACTCCATTAGCATCACTAAAACCA
GTCGATACTAATCTCCAGGACTCTGCAACTAAAGTGACTTCTTCGTCAAC
TGATTCCCAATCTATCTCCAATCAAACCAATCGACGAACCCAGTCAAACG
CGACCGAAGTTCGAACGACAAAATCCATTGTTACCACGCCATCGGAACGT
TCAACAAATAGTTCTACGTCAAATATTTTCTCCGTTACTCAAACACCAAT
TTCATCGATAATCAGTTCAATTGTCCCGCCTCCAATCACCAATAACCCGA
TTCTAATTCCGCCGTTTGTTTCCAATTCTCCAGTTTCTCTCAATGCGTTT
CCGCCTCAGCAATTTCCCGGCAAGCCTGCTAGTTCATTCATGGGTTGTGC
AATTTCTTCTACAATTGCTCCGATTGCCTTGTCAACCTTGTCAAATTCTG
TTTTGAATTCAGTAAATCTCAGCAAATCCGTGCCAGCTACAGTTCCTTCA
GCATTTGGCAATCCGATATCGGTTATTAGTAGCCGGACATTGTCAGACAA
AAATCCCAATTCAATTATACCGCCGAGAAAGTCTCCAATAACGACGAGCG
TGCAAAATAATACCACCGAAACAACATCGAAAGAATCGTTGATATCTAAC
TCATCATCAAAGTCTCTTATTTCGTCAATTTCCACCAGTGCTGACATTCA
GTCCCGCAATTCCAGTTGGAAATCCCGATCCGAAGTTCAGATATCGTCAG
CGAATCTACAGCCGCCTTCAACAATGACTGGTGTTATCGGCGAAGTGTCA
ACCAAAGATATTGTCGATGACATAGTGAGGACTTTACCAGTTACCAATAT
TCCTGATGTGCCGACAAAGAAACGAACAGCTGATCATTCTCCGGAACCAA
TAAACTGTCCAAACATTATAGTTCACCAGCCGGATAAGAAAAATGATACT
CCAGCTAAGACTCCAGATCAAATTAAAAAATTAGATAACCAGAAACGATT
GAAAACTTTTCAAAGTAAAATACCTCCTCCGAGTTCTAATGTCACGATTC
CTTCTTTGACAATCGATTTAACTGCAGAAGATGACGAGGAGCAGCAGACT
TCTGTTAACATCAAACAAGCGGTTCCTTTGGCCCAGAAATCAATGACTTG
GGTGCCTGTCAGTGGACCGATCTCCAATAACTTGAACAAAATGATCAATG
GGATTAATATGACTAAATTTCCGACGAATCATTTGAATCGAAGCGCTACC
AACAATCGAAACATAGAGAACGAGAAGCGGAAATTGGCTGAGCTCGGTAT
TGGGCATTACAAGCCCCATCAAATGCTGCACAGCAATTTCAGTGTGAAAT
CCCCAAAGGCACATATTGATCTTACAGCGGACGATGATGACGAGGATCGA
ATTCCGAACAAGCGACCGAGATTCGGCAATAGCGATAATGCTGCTGCTGC
TACTACTGCAGTAGCTACGGTTCTCGGCAGCGACATCAATACTGCCGATG
AAGAAGACGGACAGATCAACGACAACGAATCGACGGCTTCCAATAATTCA
TCAAATGTGAAGGGAGCACATAATAAAAATGCTTTGCATGTTGTATCTAA
GCGCAAATTATAGAGCGAGTGAGATGTTTAGGCATTTTATTAAGGAGTGA
TTTCGAGAATGAAATAAAGATTTATGATTTTTTAATATATATATAAATAA
ATATATTCGGTTGTGTAAATAATATCGGTACTAATAAATGTAATTTTTAT
TTGTAACTTGCTACTTACACTACAACTACGTATTTCATTCGATGGAAATG
GTAGGTTTCAATTGTGTATTCGTATTTTATTGGCTAGCAGATTGTGCTGA
TTGTAGGCCTGTGATTGGTTGACTGCTAGTTCAGAATCCTTTAATATTGG
GTTTTTCTATATAAATTAGTAAATTCTTTTTGTGTTTTCAATTTGAAATC
ATTTTTATTGATAATTTGCAATATTTTCAGGTGGTATTGTATATGTG

protein sequence of SMED30019208-orf-1

>SMED30019208-orf-1 ID=SMED30019208-orf-1|Name=SMED30019208-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1107bp
MRSDDLLLKLQKNIRINLSQKHLINLCTYFNLPISGRKNQIQEKLINFTN
TQSHETLKSMSNKADEYLRLSSSTRPRNTTTINRTSIRIVPEVLTESKLQ
TALINLLDEVPLNLRTDLSNPIITPQMELTTTFPPKPTKLPFVDYPNILL
NKKVITSPFHCCQVCLQPLTLLNYMQAPNFVVRVNTTQPLNFIITENVRN
LISNNQYKVNGKIEYKWQVLLRFVGIDVTQAKEVFANPPEIFPENIPPYM
SLIVNEISHPLWDVLPSNHKLKEGRRHPKPIQITDKLKLNTRNANGGYKQ
LVSMTWWQIPEITPYFYVGVYLERKISVREMMSLYAPNSLFNNRPMDEIL
AWVRNKFGKAPNNSQNDDDCDDLVISNVLPINLNCPVSKSRIGIPLRTIR
CEHLQCFDAVFFLSMNERRSVWKCPICDEQATPNDLFTDKFFLSILQHFK
NDEEVSDVNVNPDNSFVAVTQNRDREQVENPMPRNENSVVNQASTQPVQD
LIVLDSDEEEDVVSTIQKPSVEIQQSNQLSTGLPKLLSAPTSHTPKQVQP
PPKTTPSSIHKSTPVRESAVPSVPPPYATPLASLKPVDTNLQDSATKVTS
SSTDSQSISNQTNRRTQSNATEVRTTKSIVTTPSERSTNSSTSNIFSVTQ
TPISSIISSIVPPPITNNPILIPPFVSNSPVSLNAFPPQQFPGKPASSFM
GCAISSTIAPIALSTLSNSVLNSVNLSKSVPATVPSAFGNPISVISSRTL
SDKNPNSIIPPRKSPITTSVQNNTTETTSKESLISNSSSKSLISSISTSA
DIQSRNSSWKSRSEVQISSANLQPPSTMTGVIGEVSTKDIVDDIVRTLPV
TNIPDVPTKKRTADHSPEPINCPNIIVHQPDKKNDTPAKTPDQIKKLDNQ
KRLKTFQSKIPPPSSNVTIPSLTIDLTAEDDEEQQTSVNIKQAVPLAQKS
MTWVPVSGPISNNLNKMINGINMTKFPTNHLNRSATNNRNIENEKRKLAE
LGIGHYKPHQMLHSNFSVKSPKAHIDLTADDDDEDRIPNKRPRFGNSDNA
AAATTAVATVLGSDINTADEEDGQINDNESTASNNSSNVKGAHNKNALHV
VSKRKL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0002109	X1 cell
PLANA:0002111	X2 cell

Vocabulary: **INTERPRO**
Term	Definition
IPR038654	PINIT_sf
IPR023321	PINIT
IPR013083	Znf_RING/FYVE/PHD
IPR004181	Znf_MIZ

Vocabulary: **molecular function**
Term	Definition
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0019789	SUMO transferase activity

Vocabulary: **biological process**
Term	Definition
GO:0016925	protein sumoylation

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 808..828
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 299..323
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 367..399
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 907..933
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 577..617
None	No IPR available	MOBIDB_LITE	mobidb-lite	disorder_prediction	coord: 418..469
None	No IPR available	PANTHER	PTHR10782:SF72	SUPPRESSOR OF VARIEGATION 2-10, ISOFORM I	coord: 11..478
None	No IPR available	PANTHER	PTHR10782	ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN	coord: 11..478
None	No IPR available	CDD	cd16650	SP-RING_PIAS_like	coord: 208..254 e-value: 1.53425E-19 score: 80.7661
None	No IPR available	SUPERFAMILY	SSF57850	RING/U-box	coord: 204..277
IPR004181	Zinc finger, MIZ-type	PFAM	PF02891	zf-MIZ	coord: 207..255 e-value: 4.7E-21 score: 74.3
IPR004181	Zinc finger, MIZ-type	PROSITE	PS51044	ZF_SP_RING	coord: 196..273 score: 36.773
IPR013083	Zinc finger, RING/FYVE/PHD-type	GENE3D	G3DSA:3.30.40.10		coord: 172..294 e-value: 2.1E-30 score: 107.1
IPR038654	PINIT domain superfamily	GENE3D	G3DSA:2.60.120.780		coord: 4..151 e-value: 8.2E-12 score: 47.4
IPR023321	PINIT domain	PROSITE	PS51466	PINIT	coord: 1..152 score: 11.827