Junctophilin-1
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019130 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 16Note: Hover over icons to view figure legend
Homology
BLAST of Junctophilin-1 vs. Ensembl Human
Match: JPH3 (junctophilin 3 [Source:HGNC Symbol;Acc:HGNC:14203]) HSP 1 Score: 321.627 bits (823), Expect = 4.544e-95 Identity = 198/427 (46.37%), Postives = 270/427 (63.23%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG G+ TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W G+RQG GVR+S Y AA + P +S+ + S+++ +A D V A P R GFVLV +++++I +K KK FR++L KLRK +S L S R S RS ++ +S A++ SL E ID ETY G+WK DKR+G+GV++R+DG KYEGEW +N++ GYG FP+GTKEEG+YK+N+LV KR + LR S++++ V+ AV+ A AA AK++A A+ R ++ AE A A++AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAV--AGSPAVSRGGFVLV-AHSDSEILKSK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGG--KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAAS-RTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSF 423
BLAST of Junctophilin-1 vs. Ensembl Human
Match: JPH1 (junctophilin 1 [Source:HGNC Symbol;Acc:HGNC:14201]) HSP 1 Score: 312.383 bits (799), Expect = 1.281e-92 Identity = 189/440 (42.95%), Postives = 263/440 (59.77%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADIN-ANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W +G+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++SL + +++EG+W L DG+GVET DG TY G W+ G+R G GVR+S Y A + P +S+R+ S S+L + + P R GFVL N +AD A K+K FR+ KLRK +S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+G+KEEG+YK N+LV+ + R ++ +RH++ ++ + + AA +E AN R A+ A+ A+ A A++ + AR VA+E +PDF Q G ++K R
Sbjct: 1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADS-------PAGTRGGFVL---NFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGI--RKQLIPIRHTKTRE-KVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQR 427
BLAST of Junctophilin-1 vs. Ensembl Human
Match: JPH2 (junctophilin 2 [Source:HGNC Symbol;Acc:HGNC:14202]) HSP 1 Score: 300.827 bits (769), Expect = 5.187e-88 Identity = 193/464 (41.59%), Postives = 267/464 (57.54%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDAR--RPIDHRSGFVLVTTNNNADINANKEKKPSF-RKALFRKLRKQKSTGDLRSARMGGS-LRSTLSSNSAASQATNHSL-----PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLD 1825
+ GGRFDFDDGG+Y G W G+AHG G+ TGP+ QGE+SG W GFE GVY WPSGN + G W +GKRHG G++ KG+W+YKGE+T GF GRYG+++S SS +K+EG+W+ L DG+G ET ADG TY G ++ G+R G GVR+S Y A + P SS+R+ S ++ A DS D P R GF L N + F R AL KLR+ +S + S R S L+S LSS A+ A+ SL P ID ETY G+WK DKR+G+GV+ER+ G +YEGEW +N + GYG T P+G +EEG+Y+ NVLV+ +R + L+ ++++ VE +V+ A AAA A+++A A++ + + + Q+ SN AR +A+E APDF Q G + K R E + N+ SLL+
Sbjct: 1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSSSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTV--APDSPASPASDGPALPSPAIPRGGFALSLLANAEAAARAPKGGGLFQRGALLGKLRRAESRTSVGSQRSRVSFLKSDLSSG-ASDAASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRR--MLQLKSNKVRQKVEHSVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQE-SNIARTLARELAPDFYQPGPEYQKRRLLQE-------ILENSESLLE 451
BLAST of Junctophilin-1 vs. Ensembl Human
Match: JPH4 (junctophilin 4 [Source:HGNC Symbol;Acc:HGNC:20156]) HSP 1 Score: 251.906 bits (642), Expect = 2.763e-71 Identity = 146/360 (40.56%), Postives = 202/360 (56.11%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPID-HRSGFVLVTTNNNADINANKEKKPS----FRKA-LFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKI-FALRHSRLKD 1540
GG+FDFDDGG YVG W GRAHG G+ TGP QGE+SG W GFES GV+ P G+ Y G W +GKR G GV+ K +W Y+GE+ G GR GV ES+S ++ G W DG+G ET +DG TY G W G R G GVR+S Y +AA + P + S +S D+ P R GFVL +AD +++++ P+ FR++ L LR L S R GSLRS +SS ++ I+ + E Y+G+W+ D+R+G+GV++R++G +YEGEW N++ GYG T P+G++EEG+YK N LV R + ALR ++K+
Sbjct: 4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGL-RYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRT-SLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGP-GDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKR--GSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKE 358
BLAST of Junctophilin-1 vs. Ensembl Human
Match: JPH4 (junctophilin 4 [Source:HGNC Symbol;Acc:HGNC:20156]) HSP 1 Score: 251.906 bits (642), Expect = 2.763e-71 Identity = 146/360 (40.56%), Postives = 202/360 (56.11%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPID-HRSGFVLVTTNNNADINANKEKKPS----FRKA-LFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKI-FALRHSRLKD 1540
GG+FDFDDGG YVG W GRAHG G+ TGP QGE+SG W GFES GV+ P G+ Y G W +GKR G GV+ K +W Y+GE+ G GR GV ES+S ++ G W DG+G ET +DG TY G W G R G GVR+S Y +AA + P + S +S D+ P R GFVL +AD +++++ P+ FR++ L LR L S R GSLRS +SS ++ I+ + E Y+G+W+ D+R+G+GV++R++G +YEGEW N++ GYG T P+G++EEG+YK N LV R + ALR ++K+
Sbjct: 4 GGKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGL-RYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRT-SLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGP-GDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKR--GSLRSEVSSEVGSTGPPGSEASGPPAAAPPALIEGSATEVYAGEWRADRRSGFGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKE 358
BLAST of Junctophilin-1 vs. Ensembl Celegans
Match: jph-1 (JunctoPHilin [Source:UniProtKB/TrEMBL;Acc:Q22667]) HSP 1 Score: 341.273 bits (874), Expect = 1.140e-102 Identity = 222/591 (37.56%), Postives = 322/591 (54.48%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRP-IDHRSGFVLVTTNN--NADINANKEKKPSFRKALFRKLR--KQKSTGDL--RSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFS-LLDNQKYLNQNYKPQQM--DQLQPNLLNPSDPECLEVXXXXXXXXXXXXXXXXXEKRPNSPDPQNQKQTSSSKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTLLTSEPLIQRATATLT 2218
+ GGRFDFDDGG+YVG W +G+AHG G+ TGP+ +GE++G W GFE GVY WPSGN Y G W GKRHG G++ +G+W+YKGE+T G+ GRYGV++S +S ++++G+W DG+G E D +Y G W +G+R G G+RKS Y KAA + S A S SL S + A + + + R GFVL ++ + E+ + ++ L LR KQ STGD+ R A M GSLRS+ S+ S S+ + H L P E+++ + IETY G+WK D R+G+GV ER+DG KY+GEW NN K GYGVT F +GTKEEGRYK N+L+ + ++ IF +R S+ ++ +E+A+ A AA+ A+++A A+ R TA+ +E A A++A S AR AK+F P F Q G L NN G F + S + ++L+Q + Q L ++ P S + + + P+ Q Q +S L H P N+ P P S D E P I + ++Q P+ L T P + + +L+
Sbjct: 1 MNGGRFDFDDGGTYVGGWEEGKAHGHGVCTGPQAKGEYAGAWHYGFEVSGVYTWPSGNTYQGQWQNGKRHGLGIEQRGRWLYKGEWTQGYKGRYGVRQSANSQARYQGTWSAGFHDGYGTEIYVDSGSYQGQWLRGMRHGYGIRKSTTYEKAAKFRSKSQTHA--SLTSLRSGRVEEENAAEEHRHKEGLSGRGGFVLRANSSAPQRRRRSLSERSLAVKRTLLSGLRIKKQHSTGDIHQRVASMTGSLRSSGSTMSCTSEDSLHH--HGLQQPEEEAVEESSIETYMGEWKNDMRSGFGVCERSDGLKYQGEWANNAKCGYGVTTFKDGTKEEGRYKNNILIASSRRKGVIF-MRASKFREKLEQALGAASRAASIAQQKADIAAS-RTSTARERSEQASFIARQANDDSEVARIHAKQFDPSFKQPGTRRLLKDNN------GGESFGTDLSDAISYSRHLSQTHSKQHSFEQTLSVDMAEDMTPPSKAYHNHVMPNSNTNHVNFMPQYGYSDPNSQLQTPINSQDLLQPHIP--NIDPSIPSVSIVQDD----EKPLILQPQTNISQPGPSNLSTQAPNVMSSRFSLS 573
BLAST of Junctophilin-1 vs. Ensembl Fly
Match: jp (gene:FBgn0032129 transcript:FBtr0079861) HSP 1 Score: 319.316 bits (817), Expect = 5.091e-92 Identity = 188/432 (43.52%), Postives = 265/432 (61.34%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTT-GFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDL--RSARMGGSLRSTLSSNSAASQAT---------NHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
I GGRFDF+DGG+Y G W +G+AHG G+ TGP++QG ++G W GFE G YIWPSG+ Y G W G+RHG GV+ G+ IY+GE++ G GRYGV+ES S +K+EG+W+ DG G ET ADG Y G W +G R G G+R SA + A+ H+ ++ A+ S SL S + + V+ A + R GFVL ++ + N + +K K+RKQ+STGDL R GS+RST+SS S S + NH+ ++ E +DP V+ETY G+WK+DKR G+GVAER+DG KYEGEW+NN+K GYGVT F +GT EEG+YK N+L+ + K+H +F R +L+D + A+ +A A A +R+ + R TA A+ A+ A++A+ +A +A+EFAPDF
Sbjct: 47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQNGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKYQGQWQEGKRHGYGIRTSAPFGLASHHRR-KNLHASLS--SLRSGENGNAAKMVEKAE---EIRGGFVLTAKSDKLPVRRNSLTDKTGKKGFLMNLKMRKQRSTGDLEKRGTIASGSIRSTMSSASWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEGEWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKH-LFLARSRKLRDRIAAALSSAQRALKMAMQRSDMAIS-RMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDF 470
BLAST of Junctophilin-1 vs. Ensembl Fly
Match: jp (gene:FBgn0032129 transcript:FBtr0079860) HSP 1 Score: 319.316 bits (817), Expect = 5.091e-92 Identity = 188/432 (43.52%), Postives = 265/432 (61.34%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTT-GFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDL--RSARMGGSLRSTLSSNSAASQAT---------NHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
I GGRFDF+DGG+Y G W +G+AHG G+ TGP++QG ++G W GFE G YIWPSG+ Y G W G+RHG GV+ G+ IY+GE++ G GRYGV+ES S +K+EG+W+ DG G ET ADG Y G W +G R G G+R SA + A+ H+ ++ A+ S SL S + + V+ A + R GFVL ++ + N + +K K+RKQ+STGDL R GS+RST+SS S S + NH+ ++ E +DP V+ETY G+WK+DKR G+GVAER+DG KYEGEW+NN+K GYGVT F +GT EEG+YK N+L+ + K+H +F R +L+D + A+ +A A A +R+ + R TA A+ A+ A++A+ +A +A+EFAPDF
Sbjct: 47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQNGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKYQGQWQEGKRHGYGIRTSAPFGLASHHRR-KNLHASLS--SLRSGENGNAAKMVEKAE---EIRGGFVLTAKSDKLPVRRNSLTDKTGKKGFLMNLKMRKQRSTGDLEKRGTIASGSIRSTMSSASWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEGEWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKH-LFLARSRKLRDRIAAALSSAQRALKMAMQRSDMAIS-RMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDF 470
BLAST of Junctophilin-1 vs. Ensembl Fly
Match: jp (gene:FBgn0032129 transcript:FBtr0304056) HSP 1 Score: 319.316 bits (817), Expect = 5.091e-92 Identity = 188/432 (43.52%), Postives = 265/432 (61.34%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTT-GFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDL--RSARMGGSLRSTLSSNSAASQAT---------NHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
I GGRFDF+DGG+Y G W +G+AHG G+ TGP++QG ++G W GFE G YIWPSG+ Y G W G+RHG GV+ G+ IY+GE++ G GRYGV+ES S +K+EG+W+ DG G ET ADG Y G W +G R G G+R SA + A+ H+ ++ A+ S SL S + + V+ A + R GFVL ++ + N + +K K+RKQ+STGDL R GS+RST+SS S S + NH+ ++ E +DP V+ETY G+WK+DKR G+GVAER+DG KYEGEW+NN+K GYGVT F +GT EEG+YK N+L+ + K+H +F R +L+D + A+ +A A A +R+ + R TA A+ A+ A++A+ +A +A+EFAPDF
Sbjct: 47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQNGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKYQGQWQEGKRHGYGIRTSAPFGLASHHRR-KNLHASLS--SLRSGENGNAAKMVEKAE---EIRGGFVLTAKSDKLPVRRNSLTDKTGKKGFLMNLKMRKQRSTGDLEKRGTIASGSIRSTMSSASWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEGEWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKH-LFLARSRKLRDRIAAALSSAQRALKMAMQRSDMAIS-RMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDF 470
BLAST of Junctophilin-1 vs. Ensembl Fly
Match: jp (gene:FBgn0032129 transcript:FBtr0304057) HSP 1 Score: 319.316 bits (817), Expect = 5.091e-92 Identity = 188/432 (43.52%), Postives = 265/432 (61.34%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTT-GFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDL--RSARMGGSLRSTLSSNSAASQAT---------NHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
I GGRFDF+DGG+Y G W +G+AHG G+ TGP++QG ++G W GFE G YIWPSG+ Y G W G+RHG GV+ G+ IY+GE++ G GRYGV+ES S +K+EG+W+ DG G ET ADG Y G W +G R G G+R SA + A+ H+ ++ A+ S SL S + + V+ A + R GFVL ++ + N + +K K+RKQ+STGDL R GS+RST+SS S S + NH+ ++ E +DP V+ETY G+WK+DKR G+GVAER+DG KYEGEW+NN+K GYGVT F +GT EEG+YK N+L+ + K+H +F R +L+D + A+ +A A A +R+ + R TA A+ A+ A++A+ +A +A+EFAPDF
Sbjct: 47 INGGRFDFEDGGTYCGGWDEGKAHGHGVCTGPKHQGAYAGAWNYGFEVSGSYIWPSGSHYEGQWQNGRRHGLGVEQIGRQIYRGEWSKDGHKGRYGVRESTVSTAKYEGTWNEGYQDGSGCETYADGGKYQGQWQEGKRHGYGIRTSAPFGLASHHRR-KNLHASLS--SLRSGENGNAAKMVEKAE---EIRGGFVLTAKSDKLPVRRNSLTDKTGKKGFLMNLKMRKQRSTGDLEKRGTIASGSIRSTMSSASWISTGSEQSNLTTKSNHTESNASFTMEDEQLDPTVVETYMGEWKKDKRCGHGVAERSDGLKYEGEWYNNRKHGYGVTTFRDGTVEEGKYKNNILITSQKKKH-LFLARSRKLRDRIAAALSSAQRALKMAMQRSDMAIS-RMATAAAKAQNADAAAEQARMDCENAVRMAREFAPDF 470
BLAST of Junctophilin-1 vs. Ensembl Fly
Match: Als2 (gene:FBgn0037116 transcript:FBtr0078462) HSP 1 Score: 58.151 bits (139), Expect = 5.358e-8 Identity = 45/144 (31.25%), Postives = 60/144 (41.67%), Query Frame = 2
Query: 491 FDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMG-FESRGVYIW-----PSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGV 904
++ DG Y GE G G G P G + G + G F GVY P +Y G + +G HG GV ++IY GE+ YGV E L S K+ G + N G G G + G++S G GV
Sbjct: 758 LEYPDGSVYCGELQHGIIEGFGKMVIPTT-GLYVGNFKGGRFHGHGVYEMHCKDSPESEVYEGNFCEGLFHGHGVMRNNRYIYVGEYQANARSGYGVIEDLVSGDKYMGMFADNKRSGIGSCITNRGDYFEGSFSGDDLTGSGV 900
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Match: jph1a (junctophilin 1a [Source:ZFIN;Acc:ZDB-GENE-040724-233]) HSP 1 Score: 326.635 bits (836), Expect = 8.038e-98 Identity = 189/437 (43.25%), Postives = 271/437 (62.01%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNH---SLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++S ++ ++++G+W L DG+GVET D TY G W G+R G GVR+S Y A + P +R + + + +N + Q V D P+ R GFVL +++ ++ K+K R +LF R+LRK S + S R +T+S S+S A+ ++ +PD P + +D E+Y G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+GTKEEG+YK NVLV+ + R ++ L++ + K+ V+ AV+ A +AA A+ + + R A+ +E A+ A A + S+ AR VA E +P F Q G+ ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWSQGKRHGLGVETKGKWLYRGEWSHGFKGRYGVRQSTNTPARYDGTWSNGLQDGYGVETYGDSGTYQGQWMGGMRHGYGVRQSVPYGMATIIRSP--LRTSLASLRSVQSNGAVLQDTVPDT--PVGSRGGFVL-NFHSDTEVVTGKKKGLFRRGSLFGSLRQLRKSDSKTSISSKRSSARSDATMSRISSSDANSTISYGEGEVPDDY-TPMEDHVDATTTESYMGEWKNDKRNGFGVSERSNGLKYEGEWMNNKRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPLKNHKTKEKVDRAVEGARRSAAIARTKVEIAVS-RTSHARTKSEAADQAALAACQESDLARAVACELSPSFHQPGLEYIKQK 428
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Match: jph1a (junctophilin 1a [Source:ZFIN;Acc:ZDB-GENE-040724-233]) HSP 1 Score: 308.531 bits (789), Expect = 7.341e-95 Identity = 165/363 (45.45%), Postives = 231/363 (63.64%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHS---LPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKD 1540
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++S ++ ++++G+W L DG+GVET D TY G W G+R G GVR+S Y A + P +R + + + +N + Q V D P+ R GFVL +++ ++ K+K R +LF R+LRK S + S R +T+S S+S A+ ++ +PD P + +D E+Y G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+GTKEEG+YK NVLV+ + R ++ L++ + K+
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWSQGKRHGLGVETKGKWLYRGEWSHGFKGRYGVRQSTNTPARYDGTWSNGLQDGYGVETYGDSGTYQGQWMGGMRHGYGVRQSVPYGMATIIRSP--LRTSLASLRSVQSNGAVLQDTVPDT--PVGSRGGFVL-NFHSDTEVVTGKKKGLFRRGSLFGSLRQLRKSDSKTSISSKRSSARSDATMSRISSSDANSTISYGEGEVPDDY-TPMEDHVDATTTESYMGEWKNDKRNGFGVSERSNGLKYEGEWMNNKRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPLKNHKTKE 355
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Match: jph1b (junctophilin 1b [Source:ZFIN;Acc:ZDB-GENE-060616-389]) HSP 1 Score: 315.849 bits (808), Expect = 7.365e-94 Identity = 190/445 (42.70%), Postives = 278/445 (62.47%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLP----IPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIE 1774
+ GGRFDFDDGG++ G W DG+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KG+W+Y+GE++ GF GRYGV++SL++ +++EG+W L DG+GVET DG TY G W G+R G GVR+S Y A + P +S+R+ S S+L + SD P R GFVL ++++++ + K+K R +LF ++LRK S + S R +T+S S++ + S D +P+ +++D E+Y G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+GTKEEG+YK NVLV+ + K ++ L++++ K V+ AV+ A+ A+A A+ + + R A+ AE A+ + A + S+ AR VA++ +P+F Q G ++K R + E
Sbjct: 1 MTGGRFDFDDGGTFCGGWEDGKAHGHGICTGPKGQGEYSGSWSNGFEVVGVYTWPSGNTYKGYWAQGKRHGLGVESKGRWLYRGEWSHGFKGRYGVRQSLNTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDHMSD---------SPAGTRGGFVL-NFHSDSEVVSGKKKGLFRRGSLFGSLKQLRKSDSRSSISSKRSSARSDATMSRISSSDANSTISFGDGEVADEYMPAEDNVDATTTESYLGEWKNDKRNGFGVSERSNGMKYEGEWINNKRHGYGCTMFPDGTKEEGKYKNNVLVRGIKK--QLIPLKNTKTKQKVDRAVEGAIRASAIARTKVEIATS-RTAHARAKAEAADQASLSASQESDLARAVARDLSPNFHQPGPDYIKQRFSSE 432
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Match: jph1b (junctophilin 1b [Source:ZFIN;Acc:ZDB-GENE-060616-389]) HSP 1 Score: 315.849 bits (808), Expect = 7.365e-94 Identity = 190/445 (42.70%), Postives = 278/445 (62.47%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLP----IPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIE 1774
+ GGRFDFDDGG++ G W DG+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KG+W+Y+GE++ GF GRYGV++SL++ +++EG+W L DG+GVET DG TY G W G+R G GVR+S Y A + P +S+R+ S S+L + SD P R GFVL ++++++ + K+K R +LF ++LRK S + S R +T+S S++ + S D +P+ +++D E+Y G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+GTKEEG+YK NVLV+ + K ++ L++++ K V+ AV+ A+ A+A A+ + + R A+ AE A+ + A + S+ AR VA++ +P+F Q G ++K R + E
Sbjct: 1 MTGGRFDFDDGGTFCGGWEDGKAHGHGICTGPKGQGEYSGSWSNGFEVVGVYTWPSGNTYKGYWAQGKRHGLGVESKGRWLYRGEWSHGFKGRYGVRQSLNTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDHMSD---------SPAGTRGGFVL-NFHSDSEVVSGKKKGLFRRGSLFGSLKQLRKSDSRSSISSKRSSARSDATMSRISSSDANSTISFGDGEVADEYMPAEDNVDATTTESYLGEWKNDKRNGFGVSERSNGMKYEGEWINNKRHGYGCTMFPDGTKEEGKYKNNVLVRGIKK--QLIPLKNTKTKQKVDRAVEGAIRASAIARTKVEIATS-RTAHARAKAEAADQASLSASQESDLARAVARDLSPNFHQPGPDYIKQRFSSE 432
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Match: jph3 (junctophilin 3 [Source:ZFIN;Acc:ZDB-GENE-060503-415]) HSP 1 Score: 316.235 bits (809), Expect = 7.255e-93 Identity = 197/444 (44.37%), Postives = 270/444 (60.81%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDD--------------ARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRST--LSSNSAASQATNHSLP-----DSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLG 1741
GGRF+FDDGGSY G W +G+AHG GI TGP+ QGE++G W GFE G+Y WPSGN + G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+ES ++ K+EG+W+ L DG+G ET +DG TY G W G+R G GVR+S Y AA + P TS NSL S + + D P R GFVL T ++ A++ NK KK FR++L KLRK +S L S R S RS +S+ S+A+ N ++ LP+ + +D E+Y+G+WK DKR G GV+ R+DG +Y+GEW NK+ GYG T FP+GTKEEG+YK+N+LV KR + LR S++++ V+ AV++A +AA AK++A ++ A A+ A+ A A++AQ+ AR AKEF+P F G
Sbjct: 4 GGRFNFDDGGSYCGGWEEGKAHGHGICTGPKGQGEYAGSWSHGFEVVGIYTWPSGNTFQGTWAQGKRHGIGIENKGKWVYKGEWTHGFKGRYGVRESTGTSGKYEGTWNNGLQDGYGTETYSDGGTYQGQWVGGMRHGYGVRQSVPYGMAAVIRSP----LRTSINSLRSEHSNGTALLTGDRAPVAGVGGSGVLVVGSPAVSRGGFVL-TAHSEAELLKNK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSAASDINSTISLGEGEGELPVGD-DDVDATTTESYAGEWKNDKRTGCGVSRRSDGLQYQGEWLGNKRHGYGCTTFPDGTKEEGKYKQNILVSG--KRKNLIPLRASKIREKVDRAVESADKAADIAKQKAEIALSRTAH-ARGKADAATAAAQKAQEECRLARITAKEFSPSFQHRG 437
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Match: ing2 (inhibitor of growth family member 2 [Source:Xenbase;Acc:XB-GENE-951849]) HSP 1 Score: 320.472 bits (820), Expect = 8.491e-97 Identity = 187/444 (42.12%), Postives = 266/444 (59.91%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--------KLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KG+WIY+GE++ GF GRYGV++S+S+ ++++G+W L DG+GVET DG TY G W G+R G GVR+S Y A P SS+R+ S ++L D P+ R GFVL + +++ E +K LFR KLRK S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NN++ GYG T FP+GTKEEG+YK NVLV+ + R ++ +++++ K+ V+ A++ A AAA A+ + + R + A+ A A+ ++ A++ S+ AR VA+E +P F Q G ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGAYTWPSGNTYLGYWAQGKRHGLGVETKGRWIYRGEWSHGFKGRYGVRQSMSTPARYDGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIHSPLRTSLSSLRSEQSNGTVLHDIGVD---------SPVGSRGGFVL-------NFHSDSELMTGKKKGLFRRGSLLGSIKLRKSDSKISISSKRSSVRSDAAMSRISSSDANSTISFGDGDCDYCPVEDHVDATTTETYMGEWKNDKRTGFGVSERSNGMKYEGEWLNNRRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPIKNTKTKEKVDRAIEGAQRAAAVARTKVEIAVS-RTEHARAKANAADQASQAARQESDIARAVARELSPSFHQPGPEYIKQK 425
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Match: ing2 (inhibitor of growth family member 2 [Source:Xenbase;Acc:XB-GENE-951849]) HSP 1 Score: 320.472 bits (820), Expect = 1.452e-96 Identity = 187/444 (42.12%), Postives = 266/444 (59.91%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--------KLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KG+WIY+GE++ GF GRYGV++S+S+ ++++G+W L DG+GVET DG TY G W G+R G GVR+S Y A P SS+R+ S ++L D P+ R GFVL + +++ E +K LFR KLRK S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NN++ GYG T FP+GTKEEG+YK NVLV+ + R ++ +++++ K+ V+ A++ A AAA A+ + + R + A+ A A+ ++ A++ S+ AR VA+E +P F Q G ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGAYTWPSGNTYLGYWAQGKRHGLGVETKGRWIYRGEWSHGFKGRYGVRQSMSTPARYDGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIHSPLRTSLSSLRSEQSNGTVLHDIGVD---------SPVGSRGGFVL-------NFHSDSELMTGKKKGLFRRGSLLGSIKLRKSDSKISISSKRSSVRSDAAMSRISSSDANSTISFGDGDCDYCPVEDHVDATTTETYMGEWKNDKRTGFGVSERSNGMKYEGEWLNNRRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPIKNTKTKEKVDRAIEGAQRAAAVARTKVEIAVS-RTEHARAKANAADQASQAARQESDIARAVARELSPSFHQPGPEYIKQK 425
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Match: JPH3 (junctophilin 3 [Source:NCBI gene;Acc:105947054]) HSP 1 Score: 325.094 bits (832), Expect = 2.949e-96 Identity = 196/427 (45.90%), Postives = 265/427 (62.06%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG GI TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG GV+ KGKW+Y+GE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W+ G+R G GVR+S Y AA + P +S+ + S+++ +A D V + P R GFVL+ +++A+I NK KK FR+++ KLRK +S L S R S RS ++ +S A++ + SL E ID E Y G+WK DKR+G+GV++R+DG KYEGEW NNK+ GYG FP+GTKEEG+YK NVLV KR + LR S++++ V+ AV A AK++A A+ R ++ A+ A A +AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWQDGKAHGHGICTGPKGQGEYAGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGLGVESKGKWVYRGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWAAGIRHGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASCTVSGS--PAVSRGGFVLM-AHSDAEILKNK-KKGIFRRSILSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDINSTISLGEGETELSVIEDDIDATTTEVYMGEWKHDKRSGFGVSQRSDGLKYEGEWANNKRHGYGCMTFPDGTKEEGKYKHNVLVSG--KRKNLIPLRASKIREKVDRAVDEAERVCNIAKQKAEIAAS-RTSHSRAKADAAATAALKAQEEAQIARISAKEFSPSF 423
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Match: ing2 (inhibitor of growth family member 2 [Source:Xenbase;Acc:XB-GENE-951849]) HSP 1 Score: 321.627 bits (823), Expect = 4.315e-96 Identity = 187/444 (42.12%), Postives = 266/444 (59.91%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--------KLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KG+WIY+GE++ GF GRYGV++S+S+ ++++G+W L DG+GVET DG TY G W G+R G GVR+S Y A P SS+R+ S ++L D P+ R GFVL + +++ E +K LFR KLRK S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NN++ GYG T FP+GTKEEG+YK NVLV+ + R ++ +++++ K+ V+ A++ A AAA A+ + + R + A+ A A+ ++ A++ S+ AR VA+E +P F Q G ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGAYTWPSGNTYLGYWAQGKRHGLGVETKGRWIYRGEWSHGFKGRYGVRQSMSTPARYDGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIHSPLRTSLSSLRSEQSNGTVLHDIGVD---------SPVGSRGGFVL-------NFHSDSELMTGKKKGLFRRGSLLGSIKLRKSDSKISISSKRSSVRSDAAMSRISSSDANSTISFGDGDCDYCPVEDHVDATTTETYMGEWKNDKRTGFGVSERSNGMKYEGEWLNNRRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPIKNTKTKEKVDRAIEGAQRAAAVARTKVEIAVS-RTEHARAKANAADQASQAARQESDIARAVARELSPSFHQPGPEYIKQK 425
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Match: ing2 (inhibitor of growth family member 2 [Source:Xenbase;Acc:XB-GENE-951849]) HSP 1 Score: 322.013 bits (824), Expect = 6.315e-96 Identity = 187/444 (42.12%), Postives = 266/444 (59.91%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--------KLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KG+WIY+GE++ GF GRYGV++S+S+ ++++G+W L DG+GVET DG TY G W G+R G GVR+S Y A P SS+R+ S ++L D P+ R GFVL + +++ E +K LFR KLRK S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NN++ GYG T FP+GTKEEG+YK NVLV+ + R ++ +++++ K+ V+ A++ A AAA A+ + + R + A+ A A+ ++ A++ S+ AR VA+E +P F Q G ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSHGFEVVGAYTWPSGNTYLGYWAQGKRHGLGVETKGRWIYRGEWSHGFKGRYGVRQSMSTPARYDGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIHSPLRTSLSSLRSEQSNGTVLHDIGVD---------SPVGSRGGFVL-------NFHSDSELMTGKKKGLFRRGSLLGSIKLRKSDSKISISSKRSSVRSDAAMSRISSSDANSTISFGDGDCDYCPVEDHVDATTTETYMGEWKNDKRTGFGVSERSNGMKYEGEWLNNRRHGYGCTIFPDGTKEEGKYKNNVLVRGI--RKQLIPIKNTKTKEKVDRAIEGAQRAAAVARTKVEIAVS-RTEHARAKANAADQASQAARQESDIARAVARELSPSFHQPGPEYIKQK 425
BLAST of Junctophilin-1 vs. Ensembl Mouse
Match: Jph3 (junctophilin 3 [Source:MGI Symbol;Acc:MGI:1891497]) HSP 1 Score: 324.324 bits (830), Expect = 3.208e-96 Identity = 199/427 (46.60%), Postives = 270/427 (63.23%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG G+ TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W G+RQG GVR+S Y AA + P +S+ + S+++ +A D V A P R GFVLV +++++I +K KK FR++L KLRK +S L S R S RS ++ +S A++ SL E ID ETY G+WK DKR+G+GV++R+DG KYEGEW +N++ GYG FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A AA AK++A A+ R ++ AE A A++AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGAALHPDASPAV--AGSPAVSRGGFVLV-AHSDSEILKSK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQNVLVSG--KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAAS-RTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSF 423
BLAST of Junctophilin-1 vs. Ensembl Mouse
Match: Jph3 (junctophilin 3 [Source:MGI Symbol;Acc:MGI:1891497]) HSP 1 Score: 324.324 bits (830), Expect = 3.208e-96 Identity = 199/427 (46.60%), Postives = 270/427 (63.23%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG G+ TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W G+RQG GVR+S Y AA + P +S+ + S+++ +A D V A P R GFVLV +++++I +K KK FR++L KLRK +S L S R S RS ++ +S A++ SL E ID ETY G+WK DKR+G+GV++R+DG KYEGEW +N++ GYG FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A AA AK++A A+ R ++ AE A A++AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGAALHPDASPAV--AGSPAVSRGGFVLV-AHSDSEILKSK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQNVLVSG--KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAAS-RTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSF 423
BLAST of Junctophilin-1 vs. Ensembl Mouse
Match: Jph1 (junctophilin 1 [Source:MGI Symbol;Acc:MGI:1891495]) HSP 1 Score: 315.079 bits (806), Expect = 1.015e-93 Identity = 189/439 (43.05%), Postives = 264/439 (60.14%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W +G+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++SL + +++EG+W L DG+GVET DG TY G W+ G+R G GVR+S Y A + P +S+R+ S S+L +A A P R GFVL N +AD K+K FR+ KLRK +S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+G++ER++G KYEGEW NNK+ GYG T FP+G+KEEG+YK N+LV+ + R ++ +R+++ ++ + + AA +E AN R A+ A+ A+ A A++ + AR VA+E +PDF Q G ++K R
Sbjct: 1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVL------HEAAAAAADSPAGTRGGFVL---NFHADTELGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGI--RKQLIPIRNTKTRE-KVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYIKQR 427
BLAST of Junctophilin-1 vs. Ensembl Mouse
Match: Jph2 (junctophilin 2 [Source:MGI Symbol;Acc:MGI:1891496]) HSP 1 Score: 298.901 bits (764), Expect = 1.664e-87 Identity = 185/461 (40.13%), Postives = 263/461 (57.05%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIP------SRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLD 1825
+ GGRFDFDDGG+Y G W G+AHG G+ TGP+ QGE+SG W GFE GVY WPSGN + G W +GKRHG G++ KG+W+YKGE+T GF GRYG+++S +S +K+EG+W+ L DG+G ET ADG TY G ++ G+R G GVR+S Y A + P SS+R+ S ++ + + + P R GF L A A + + R L +LR+ +S L S R S + S+ A+ A+ SL + P ID ETY G+WK DKR+G+GV+ER+ G +YEGEW +N + GYG T P+G +EEG+Y+ NVLV+ +R + L+ S+++ VE V+ A AAA A+++A A++ + + + Q+ SN AR +AKE APDF Q G + K R E + N+ SLL+
Sbjct: 1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPMLPSPPVP---RGGFALTLL---ATAEAARPQGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRR--VLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQE-SNIARTLAKELAPDFYQPGPEYQKRRLLQE-------ILENSESLLE 445
BLAST of Junctophilin-1 vs. Ensembl Mouse
Match: Jph2 (junctophilin 2 [Source:MGI Symbol;Acc:MGI:1891496]) HSP 1 Score: 298.901 bits (764), Expect = 1.664e-87 Identity = 185/461 (40.13%), Postives = 263/461 (57.05%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIP------SRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLD 1825
+ GGRFDFDDGG+Y G W G+AHG G+ TGP+ QGE+SG W GFE GVY WPSGN + G W +GKRHG G++ KG+W+YKGE+T GF GRYG+++S +S +K+EG+W+ L DG+G ET ADG TY G ++ G+R G GVR+S Y A + P SS+R+ S ++ + + + P R GF L A A + + R L +LR+ +S L S R S + S+ A+ A+ SL + P ID ETY G+WK DKR+G+GV+ER+ G +YEGEW +N + GYG T P+G +EEG+Y+ NVLV+ +R + L+ S+++ VE V+ A AAA A+++A A++ + + + Q+ SN AR +AKE APDF Q G + K R E + N+ SLL+
Sbjct: 1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGFEVAGVYTWPSGNTFEGYWSQGKRHGLGIETKGRWLYKGEWTHGFKGRYGIRQSTNSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQSVPYGMAVVVRSPLRTSLSSLRSEHSNGTVAPDSPAADGPMLPSPPVP---RGGFALTLL---ATAEAARPQGLFTRGTLLGRLRRSESRTSLGSQRSRLSFLKSELSSGASDAASTGSLAEGAEGPDDAAAPFDADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGRTTLPDGHREEGKYRHNVLVKGTKRR--VLPLKSSKVRQKVEHGVEGAQRAAAIARQKAEIAASRTSHAKAKAEAAEQAALAANQE-SNIARTLAKELAPDFYQPGPEYQKRRLLQE-------ILENSESLLE 445
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Match: sp|Q9ET77|JPH3_MOUSE (Junctophilin-3 OS=Mus musculus OX=10090 GN=Jph3 PE=1 SV=1) HSP 1 Score: 324.324 bits (830), Expect = 2.244e-95 Identity = 199/427 (46.60%), Postives = 270/427 (63.23%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG G+ TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W G+RQG GVR+S Y AA + P +S+ + S+++ +A D V A P R GFVLV +++++I +K KK FR++L KLRK +S L S R S RS ++ +S A++ SL E ID ETY G+WK DKR+G+GV++R+DG KYEGEW +N++ GYG FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A AA AK++A A+ R ++ AE A A++AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECTGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGAALHPDASPAV--AGSPAVSRGGFVLV-AHSDSEILKSK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWVSNRRHGYGCMTFPDGTKEEGKYKQNVLVSG--KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAAS-RTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSF 423
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Match: sp|Q8WXH2|JPH3_HUMAN (Junctophilin-3 OS=Homo sapiens OX=9606 GN=JPH3 PE=1 SV=2) HSP 1 Score: 321.627 bits (823), Expect = 2.182e-94 Identity = 198/427 (46.37%), Postives = 270/427 (63.23%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSLPIPSRE------SIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W DG+AHG G+ TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+E + +K+EG+W L DG+G ET +DG TY G W G+RQG GVR+S Y AA + P +S+ + S+++ +A D V A P R GFVLV +++++I +K KK FR++L KLRK +S L S R S RS ++ +S A++ SL E ID ETY G+WK DKR+G+GV++R+DG KYEGEW +N++ GYG FP+GTKEEG+YK+N+LV KR + LR S++++ V+ AV+ A AA AK++A A+ R ++ AE A A++AQ+ + AR AKEF+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEDGKAHGHGVCTGPKGQGEYTGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQSVPYGMAAVIRSPLRTSINSLRSEHTNGTALHPDASPAV--AGSPAVSRGGFVLV-AHSDSEILKSK-KKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSTASDIHSTISLGEAEAELAVIEDDIDATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGG--KRKNLIPLRASKIREKVDRAVEAAERAATIAKQKAEIAAS-RTSHSRAKAEAALTAAQKAQEEARIARITAKEFSPSF 423
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Match: sp|Q9ET80|JPH1_MOUSE (Junctophilin-1 OS=Mus musculus OX=10090 GN=Jph1 PE=1 SV=1) HSP 1 Score: 315.079 bits (806), Expect = 7.103e-93 Identity = 189/439 (43.05%), Postives = 264/439 (60.14%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W +G+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++SL + +++EG+W L DG+GVET DG TY G W+ G+R G GVR+S Y A + P +S+R+ S S+L +A A P R GFVL N +AD K+K FR+ KLRK +S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+G++ER++G KYEGEW NNK+ GYG T FP+G+KEEG+YK N+LV+ + R ++ +R+++ ++ + + AA +E AN R A+ A+ A+ A A++ + AR VA+E +PDF Q G ++K R
Sbjct: 1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGVYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVL------HEAAAAAADSPAGTRGGFVL---NFHADTELGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGI--RKQLIPIRNTKTRE-KVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYIKQR 427
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Match: sp|Q9HDC5|JPH1_HUMAN (Junctophilin-1 OS=Homo sapiens OX=9606 GN=JPH1 PE=1 SV=2) HSP 1 Score: 312.383 bits (799), Expect = 6.154e-92 Identity = 189/440 (42.95%), Postives = 263/440 (59.77%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADIN-ANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W +G+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++SL + +++EG+W L DG+GVET DG TY G W+ G+R G GVR+S Y A + P +S+R+ S S+L + + P R GFVL N +AD A K+K FR+ KLRK +S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+G+KEEG+YK N+LV+ + R ++ +RH++ ++ + + AA +E AN R A+ A+ A+ A A++ + AR VA+E +PDF Q G ++K R
Sbjct: 1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADS-------PAGTRGGFVL---NFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGI--RKQLIPIRHTKTRE-KVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYVKQR 427
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Match: sp|Q9GKY8|JPH1_RABIT (Junctophilin-1 OS=Oryctolagus cuniculus OX=9986 GN=JPH1 PE=2 SV=1) HSP 1 Score: 309.686 bits (792), Expect = 6.772e-91 Identity = 187/440 (42.50%), Postives = 262/440 (59.55%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADIN-ANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS--SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W +G+AHG GI TGP+ QGE+SG W GFE G Y WPSGN Y G W +GKRHG GV+ KGKW+Y+GE++ GF GRYGV++SL + +++EG+W L DG+GVET DG TY G W+ G+R G GVR+S Y A + P +S+R+ S S+L + P R GFVL N +AD A K+K FR+ KLRK +S + S R + +S S+S A+ + D P + +D ETY G+WK DKR G+G++ER++G KYEGEW NNK+ GYG T FP+G+KEEG+YK N+LV+ + R ++ +R+++ ++ + + AA +E AN R A+ A+ A+ A A++ + AR VA+E +PDF Q G ++K R
Sbjct: 1 MTGGRFDFDDGGTYCGGWEEGKAHGHGICTGPKGQGEYSGSWSHGFEVVGGYTWPSGNTYQGYWAQGKRHGLGVETKGKWMYRGEWSHGFKGRYGVRQSLCTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWAGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHDAAAAADT-------PTGTRGGFVL---NFHADAELAGKKKGGLFRRGSLLGSMKLRKSESKSSISSKRSSVRSDAAMSRISSSDANSTISFGDVDCDFCPVEDHVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWANNKRHGYGCTVFPDGSKEEGKYKNNILVRGI--RKQLIPIRNTKTRE-KVDRAIEGAQRAAAMARTKVEIANSRTAHARAKADAADQAALAARQECDIARAVARELSPDFYQPGPDYIKQR 427
BLAST of Junctophilin-1 vs. TrEMBL
Match: G4VRF7 (Putative junctophilin OS=Schistosoma mansoni OX=6183 GN=Smp_084090 PE=4 SV=1) HSP 1 Score: 626.32 bits (1614), Expect = 0.000e+0 Identity = 437/1087 (40.20%), Postives = 584/1087 (53.73%), Query Frame = 2
Query: 470 SVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDR---------QAFVDDAR------RPIDHRSGFVLVTTN----------------NNADINANKEKKPSFRKALFRKLRKQKSTGDL-----------------------RSARMGGSLRSTLSSNSAASQATNHSL-----------PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDP----ECLEVXXXXXXXXXXXX---------XXXXXEKRPN----------SPDPQNQKQTSSSKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTLLTSEPLIQRATATLTRQ--KAPQKIHSNI----INIQPQNPKKEGLHY-------------AIVQSGDVIKPQIAQXXXXXXXXXXXPRNVLVKEFDTGNDFFDYYSNNQN------------ELNDGNFIDYEYEERRKIENEVLESKATRLEE----RRRSVPSIMTSKPVTANLTSSVKY----PDNKYD-------------------IVHSSEILNS-TTSVYIIENGIRKRMKADENILPR------------QPPLSPKSNRLMGKRIQ-------------------------NPLNIEPEADELTPLPRNYKIESSHN-PHRKLEGSLPDVSY--------------CNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHIL 3133
S +EGGRFDFDDGGSYVGEWC+GRAHGLGIATGPENQGE+SGEW MGFESRGVYIWPSGNIY+G W+KGKRHGEGVQ+KG+W+Y+G FTTGFCGRYG+KESL+S +K+EGSWHLN FDGFGVETN+DGS Y+GAWSKG+RQGLGVR+SA Y+ AA +VRAA SQNSL S DS+R D R RP + RSGFVL T+ EKK F++++FRKLRKQKSTGDL R R GGSLRS +S+ +SQ T +S L E + PNV ETYSGQW ED+R+GYGVAER+DG +Y GEWFNNKKDGYG T+ +GTKEEGRYKEN+LVQ L+++ K+F LRH++L+D++EEAVKNA +AA A+E + E+A QRAQTA+ A TA+ +A+EA+KLS AR +A+EF+P+F+QLG+LW K +N + K NN L+ + + N Q L+ N L P + LEVSGGSR+GSFRSS + E PN + +P Q SK G +N+ Q + ++ G ++ A T T L P Q+ A Q +P I S I ++PQN +G Y A + S + ++ + + S + LV+ +T Y N Q ++N+ + +E+ + E + T L RRR++PSIMT P+ + +K P+++ + VHS+E L + + YIIENGIRKR++A+ + + P + ++N L G R + N + +PE+ +L PLP++Y IES N P E S+PD+S C + +++R+E ++LSQ RRQE+ HE ER++RGEIVIR+ADIKDW NF IV +LL+N +A F ++L
Sbjct: 4 SEMEGGRFDFDDGGSYVGEWCEGRAHGLGIATGPENQGEYSGEWNMGFESRGVYIWPSGNIYSGTWLKGKRHGEGVQIKGRWVYRGSFTTGFCGRYGIKESLTSCAKYEGSWHLNQFDGFGVETNSDGSIYAGAWSKGMRQGLGVRRSAPYALAAEFN--RTVRAAQSQNSLPSGTDSERGWKGTNSSGGGSGGDVRNSAERGRPDERRSGFVLRATSCPLPSSLSNNSRSSSSGYRSATPTTEKKSIFKRSIFRKLRKQKSTGDLSMVGGRSIGAFSTCGGSGGLFHSRGRRPGGSLRSNIST---SSQITTNSFGRGDVKAVGNGGQGLHEFMEEPLGPNVTETYSGQWNEDRRSGYGVAERSDGLRYAGEWFNNKKDGYGTTYRTDGTKEEGRYKENILVQALNRKSKLFMLRHTKLRDAIEEAVKNAEDAAKKAQESSYESAFQRAQTARTVAGTADARAREARKLSEEARAIAREFSPEFVQLGILWEK-QNPLMKKDVFGFSSNNEEDLIARGRRTDVNSLHAQ-GMLKENTLGPDNSAQIGNSLEVSGGSRQGSFRSSFRRRGNAAPGLQQNEHYPNDHYKYEDEMQTSNPNIDSQRYHSKEFHGVGKENNLNTQYRKQIDSQNATLGYQRSPAGRPIARAA-TTGFTGLGYSPSDQQQFAQHMAQHPHSPYLIASASQQLDIPVEPQNNPSKGFEYGTMPRAHNRPTDTASLHSPVINSAKLMKTGAHRSTEIRIDKTQLVQPCETYRAHVGYVDNFQTHNFQNMEMDFNGQINNEDMFMDNWEQESVLSKEPVPPPETPLSSINKVRRRTLPSIMTEPPIQVTRNACIKMGSQIPNSRRNETTKGSTLSSKLSSIIDDQTVHSAENLPADAAATYIIENGIRKRVQAETHHRQQNQRDKISKGSTGSPQKASETNYLEGSRPEWTTAYDPYRPAMENTGVITANRSGANKQHRDPESPDLLPLPKSYVIESIINLPGAVKEASMPDISTNRGHTAGRYDSPSRCTAAQQPVSGVLTREEVARLSQARRQELYHEMERRKRGEIVIRLADIKDWIHANFVIVFVLLINASLAFFFFNLL 1082
BLAST of Junctophilin-1 vs. TrEMBL
Match: A0A095BXM5 (Junctophilin-1 OS=Schistosoma haematobium OX=6185 GN=MS3_01977 PE=4 SV=1) HSP 1 Score: 621.313 bits (1601), Expect = 0.000e+0 Identity = 441/1086 (40.61%), Postives = 588/1086 (54.14%), Query Frame = 2
Query: 470 SVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDR---------QAFVDDAR------RPIDHRSGFVLVTTN----------------NNADINANKEKKPSFRKALFRKLRKQKSTGDL-----------------------RSARMGGSLRSTLSSNSAASQATNHSL-----------PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDP----ECLEVXXXXXXXXXXXXXXXXXEKRP----NSPDP------QNQKQTSS---------SKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTL-LTSEPLIQRATATLTRQKAPQKIHSNI----INIQPQNPKKEGLHY-------------AIVQSGDVIKPQIAQXXXXXXXXXXXPRNVLVKEFDTGNDFFDYYSNNQ------------NELNDGNFIDYEYEERRKIENEVL---ESKATRLEERRR-SVPSIMTSKPVTANLTSSVK----YPDNKYD-------------------IVHSSEILNS-TTSVYIIENGIRKRMKAD-----ENILPRQ-------PPLSPKSNRLMGKRIQ-------------------------NPLNIEPEADELTPLPRNYKIES-SHNPHRKLEGSLPDVSY--------------CNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHIL 3133
S +EGGRFDFDDGGSYVGEWC+GRAHGLGIATGPENQGE+SGEW MGFESRGVYIWPSGNIY+G W+KGKRHGEGVQ+KG+W+Y+G FTTGFCGRYG+KESL+S +K+EGSWHLN FDGFGVETN+DGS Y+GAWSKG+RQGLGVR+SA Y+ AA +VRAA SQNSL S DS+R D R RP + RSGFVL T+ EKK F+++ FRKLRKQKSTGDL R R GGSLRS LS+ +SQ T +S L E++ PNV ETYSGQW ED+R+GYGVAER+DG +Y GEWFNNKKDGYG+T+ +GTKEEGRYKEN+LVQ L+++ K+F LRH++L+D++EEAVKNA +AA A+E + E+A QRAQTA+ A TA+ +A+EA+KLS AR +A+EF+P+F+QLG++W K ++ + G NN L + + N Q L+ N L P + LEVSGGSR+GSFRSSFRR G P N P Q++ QTS+ SK G +N+ Q + ++ G ++ A T L S Q A +P I S I I+PQN G Y A + S + ++ + + S + LV+ +T Y N+Q ++N+ +E+ + E + E+ + + + RR ++PSIMT P+ + K P+++ + VHS+E L + + YIIENGIRKR++A+ +N R P + ++N L G R + N + +PE+ +L PLP++Y IES H P E S+PD+S C + +++R+E ++LSQ RRQE+ HE ER++RGEIVIR+ADIKDW NF IV +LL+N +A F ++L
Sbjct: 4 SEMEGGRFDFDDGGSYVGEWCEGRAHGLGIATGPENQGEYSGEWNMGFESRGVYIWPSGNIYSGTWLKGKRHGEGVQIKGRWVYRGSFTTGFCGRYGIKESLTSCAKYEGSWHLNQFDGFGVETNSDGSIYAGAWSKGMRQGLGVRRSAPYALAAEFN--RTVRAAQSQNSLPSGTDSERGWKGTNSSGGGSGGDVRNSAERGRPDERRSGFVLRATSCPLPSSLSNNSRSSSSGYRSATPTTEKKSIFKRSFFRKLRKQKSTGDLSMVGGRSIGTFSTCGGSGGLFHSRGRRPGGSLRSNLST---SSQITTNSFGRGDVKAVGNGGQGLHEFMEETLGPNVTETYSGQWNEDRRSGYGVAERSDGLRYAGEWFNNKKDGYGITYRTDGTKEEGRYKENILVQGLNRKSKLFMLRHTKLRDAIEEAVKNAEDAAKKAQESSYESAFQRAQTARTVAGTADARAREARKLSEEARAIAREFSPEFVQLGIMWEKQNPLVKKDIFG-FSSNNEEDLTARGRRTDLNSLHTQ-GMLKENTLGPENSAQIGNSLEVSGGSRQGSFRSSFRRRGNAAPGLQQNEHYPNDHYKYQDEMQTSNPNIDSQRYHSKEFHGVGKENNLNTQYRKQIDSQNTTLRYQRSPAGRPIARAATTGFTGLGYPSSDQQQFAQHMAQHPHSPYLIASASQQLDIPIEPQNNSSRGFEYSTMPRTHNRPTDTASLHSPVINSAKLMKTGAHRSTEIRIDKTQLVQPCETYRAHIGYVDNSQIHDFQNMEMNFNGQINNEEMFMDNWEQESVLSKEPVPPPETPLSSINKVRRRTLPSIMTEPPIQLTRNAYTKLGSQMPNSRRNETTKGSTLSSKLSSIIDDQTVHSAENLPADAAATYIIENGIRKRVQAETHHRQQNQRDRTSTGPTGLPQKASETNYLEGSRPEWTTAYDPYRPAMENTGVITVNRSGTNKQHHDPESPDLLPLPKSYVIESIVHLPGAVKEASMPDISINRGHTAGRYDSPSRCTAAQQPVSGVLTREEVARLSQARRQELYHEMERRKRGEIVIRLADIKDWINANFVIVFVLLINASLAFFFFNLL 1082
BLAST of Junctophilin-1 vs. TrEMBL
Match: A0A0X3NXT2 (Junctophilin-3 OS=Schistocephalus solidus OX=70667 GN=JPH3 PE=4 SV=1) HSP 1 Score: 530.02 bits (1364), Expect = 6.518e-167 Identity = 282/489 (57.67%), Postives = 354/489 (72.39%), Query Frame = 2
Query: 467 MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFV------------DDARRPIDHRSGFVLVTTNNNADINANK-----------EKKPSFRKALFRKLRKQKSTGDLRSA------------------------RMGGSLRSTLSSNSAASQATNHSLPD----------SLPIPSR--ESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLK 1756
M+ EGGRFDFDDGGSYVGEWC+GRAHGLGIATGP+NQGE+SGEW+MGFESRGVY+WPSGNIYAGGW+KGKRHGEGVQ+KG+WIY+G FT GFCGRYG+KESL++ +++EGSWHLN FDGFGVETN+DGSTY+G WSKG+RQGLGVRKSA Y A+ ++ +VRA+ SQ+SL SA DS+R D +R + RSGFVL +++ + + +KK SFRK L RKLRK KSTGDL S R GGSLRS + S SQ T++S+ D PI E + PNV ETYSGQW ED+R+GYGVAER+DG +YEGEWFNNKKDG+GVT+ P+GTKEEGRYKEN+LVQ+L KR+K++ LRHS+LK+S+EEAV+ A EAA +A+E++ E A+QRAQ+A++ A ++E KA+EA++LS AR +A+EFA DFIQ+G+ W K
Sbjct: 1 MAGAEGGRFDFDDGGSYVGEWCEGRAHGLGIATGPDNQGEYSGEWIMGFESRGVYVWPSGNIYAGGWLKGKRHGEGVQVKGRWIYRGAFTAGFCGRYGIKESLTTCARYEGSWHLNQFDGFGVETNSDGSTYAGGWSKGMRQGLGVRKSAPYGLAS--ENNRAVRASQSQSSLPSAQDSERGWRGVGSSGSGNGDQPDRSRSELAIRSGFVLRSSSQPIGGSPPRGMRDFRSPSPSDKKTSFRKFLMRKLRKPKSTGDLSSVGPHTVGGLSATGTPSLGRFHLGIPRPGGSLRSNI---SGGSQLTSNSVLDHQSRYFAASGGTPIVDTLDEPLTPNVTETYSGQWNEDRRSGYGVAERSDGLRYEGEWFNNKKDGFGVTYHPDGTKEEGRYKENILVQSLSKRNKLYLLRHSKLKESLEEAVRKANEAAKEAQEKSAEVAHQRAQSARSVATSSEGKAEEARRLSEQARTIAREFASDFIQMGIQWEK 484 HSP 2 Score: 110.923 bits (276), Expect = 7.964e-21 Identity = 84/253 (33.20%), Postives = 127/253 (50.20%), Query Frame = 2
Query: 2522 SKATRLEERRRSVPSI-MTSKPVTANLT-------SSVKYPDNKYDIVHSSE-ILNSTTSVYIIENGIRKRMKADEN----ILP-------RQP--------PLSP---------KSNRLMGKRIQNPL----NIEPEADELTPLPRNYKIESSHNPHRKLEGSLPDVS--YCNEIKTKTGT------LMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHIL 3133
S ATR R S+P TS P TA LT S++ + HS+E + YIIE+GIRKR++ + + P R P L P + G+R+ N ++ ++ ++ +P Y IE N ++ S+PDVS + + GT L++R E S+LSQQRRQEIL E ER++RGEI+IR+ADIKDW + NF +V++LL+N +A F++++
Sbjct: 722 SNATR-SSREASIPQARFTSSPKTAMLTGRPGDKRSTLPSRGASLETTHSTENLAEEELERYIIEDGIRKRVQPTRSPQRQLNPGTVVTGYRHPRAGTLERRDLGPTRLHDLDETRQGSFTGRRLGNGFPEVSQVDYDSRDVADMPDAYIIEPVPNAATCVDTSMPDVSKHLVDGLGGIGGTRLGISGLLTRDEVSRLSQQRRQEILLEMERKKRGEIIIRLADIKDWVRANFVVVIVLLINACLAFLFINLV 973
BLAST of Junctophilin-1 vs. TrEMBL
Match: A0A0R3W685 (Uncharacterized protein OS=Taenia asiatica OX=60517 GN=TASK_LOCUS5689 PE=4 SV=2) HSP 1 Score: 521.546 bits (1342), Expect = 8.062e-164 Identity = 281/489 (57.46%), Postives = 351/489 (71.78%), Query Frame = 2
Query: 467 MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDR-----QAFVDDARRPIDH---------RSGFVLVTTNNNADI--------------NANKEKKPSFRKALFRKLRKQKSTGDLRSA----------------------RMGGSLRSTLSSNSAASQATNH-SLPDSLPIPSRESID----PNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNN 1768
M+ EGGRFDFDDGGSYVGEWC+ RAHG GIATGP+NQGE+SGEW MGFESRGVY+WPSGN+YAGGW+KGKRHGEGVQ+KG+WIY+G FT+GF GRYGVKESL++ +++EGSWHLN FDGFGVETN+DGS Y+GAWSKG+RQGLGVRKSA + AA H S+VRAA SQ+SL S +DSDR + +DH RSGFVL T+ +++ +++ S ++ L RKLRK KSTGDL S R GGSLRS +S + S H S DS I +++D PNV ETYSGQW ED+R+GYGVAER+DG +YEGEWFNNKKDGYGVT+ P+G++EEGRYKEN++VQ L KR K++ LRHS+LKD+VEEAV+ A E+A +A+E++ ETA+QRAQTA++ A+TAEI+A+EA+ +S+ AR +A EFA DFIQ+GV W RNN
Sbjct: 1 MATAEGGRFDFDDGGSYVGEWCENRAHGFGIATGPDNQGEYSGEWNMGFESRGVYVWPSGNLYAGGWLKGKRHGEGVQIKGRWIYRGAFTSGFYGRYGVKESLTTCARYEGSWHLNQFDGFGVETNSDGSIYAGAWSKGMRQGLGVRKSAPWGLAAEHH--STVRAAQSQSSLPSTHDSDRGGWRGPGSSGGSAGSVDHIHGGRFETFRSGFVLKATSYPPGATPPPSRSQSAAPFRSSSNDRRTSLKQFLLRKLRKPKSTGDLSSVGPHTIGGPGSAGSGRFGGMHGPRTGGSLRSNISGVTGNSMFVEHQSRADSAGIGVTDTLDEPLGPNVTETYSGQWNEDRRSGYGVAERSDGLRYEGEWFNNKKDGYGVTYHPDGSREEGRYKENIIVQPLMKRTKLYLLRHSKLKDNVEEAVRKARESAKEAQEKSAETAHQRAQTARSVAKTAEIRAEEAKNISDQARSIATEFASDFIQMGVQW--ERNN 485 HSP 2 Score: 95.5153 bits (236), Expect = 5.592e-16 Identity = 70/188 (37.23%), Postives = 96/188 (51.06%), Query Frame = 2
Query: 2624 NKYDIVHSSEILNSTTSVYIIENGIRKRM---KADE--------------NILPRQPPLSP--------KSNRLMGKR-IQNPLNIEPEADELTPLPRNYKIESSHNPHRK-LEGSLPDVSYCNE-----------IKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNF 3073
N D+ HSSE L T YIIE+G++KR+ +A E L R +SP ++ RL G + + L + + EL PLP YKIES N LE S+PDVS E ++ G L++R E +L QQRR E+L ++ER++RGEI+IR+ADIKDW N
Sbjct: 755 NLDDVHHSSENLVET---YIIEDGVKKRVQPTRASEASGLLAKGNAPSAAGTLRRGHAVSPDRRLKSGDEARRLAGGTGVPHRLETDFDTGELLPLPDAYKIESVGNLRTGGLETSMPDVSKGVEGMLLSKGGPGSVRLGIGGLLTRDEVCRLGQQRRHELLLDRERKKRGEIIIRLADIKDWLCANI 939
BLAST of Junctophilin-1 vs. TrEMBL
Match: A0A4Z2CXS7 (Junctophilin-1 OS=Schistosoma japonicum OX=6182 GN=EWB00_006522 PE=4 SV=1) HSP 1 Score: 523.472 bits (1347), Expect = 2.762e-163 Identity = 278/492 (56.50%), Postives = 347/492 (70.53%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDR---------QAFVDDAR------RPIDHRSGFVLVTTN----------------NNADINANKEKKPSFRKALFRKLRKQKSTGDL-----------------------RSARMGGSLRSTLSSNSAASQATNHSL-----------PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLK 1756
+EGGRFDFDDGGSYVGEWC+GRAHGLGIATGPENQGE+SGEW MGFESRGVYIWPSGNIY+G W+KGKRHGEGVQ+KG+W+Y+G FTTGFCGRYG+KESL+S +K+EGSWHLN FDGFGVETN+DGS Y+GAWSKG+RQGLGVR+SA Y+ AA +VRA+ SQNSL S DS+R D R RP + RSGFVL +T+ KK F++++F+KLRKQKSTGDL R R GGSLRS +S+ +SQ T +S L E++ PNV ETYSGQW ED+R+GYGVAER+DG +Y GEWFNNKKDGYGVT+ +GTKEEGRYKEN+L+Q L+++ K+F LRH++L+D++EEAVKNA +AA A+E + E+A QRAQTA+ A TA+++A+EA+KLS AR +A+EF+P+F+QLG++W K
Sbjct: 6 LEGGRFDFDDGGSYVGEWCEGRAHGLGIATGPENQGEYSGEWNMGFESRGVYIWPSGNIYSGTWLKGKRHGEGVQIKGRWVYRGSFTTGFCGRYGIKESLTSCAKYEGSWHLNQFDGFGVETNSDGSVYAGAWSKGMRQGLGVRRSAPYALAAEFS--RTVRASQSQNSLPSGTDSERGWRGTNSSGGGSGGDVRNSVERGRPDERRSGFVLRSTSCPLPSPLSNNSRSSSSGYRSATPTTGKKSIFKRSIFKKLRKQKSTGDLSMVGGRAVGTFSTGGGSGGLFHGRGRRPGGSLRSNIST---SSQITTNSFGRNDVKAVGNGGQGLHEFMEETLGPNVTETYSGQWNEDRRSGYGVAERSDGLRYAGEWFNNKKDGYGVTYRTDGTKEEGRYKENILIQALNRKSKLFMLRHTKLRDAIEEAVKNAEDAAKKAQESSYESAYQRAQTARTVAGTADLRAREARKLSEEARAIAREFSPEFVQLGLMWEK 492 HSP 2 Score: 129.413 bits (324), Expect = 1.828e-26 Identity = 105/340 (30.88%), Postives = 158/340 (46.47%), Query Frame = 2
Query: 2390 LVKEFDTGNDFFDYYSNNQN------------ELNDGNFIDYEYEERRKIENEVLESKATRLEE----RRRSVPSIMTSKPV----TANLTSSVKYPDNKYD-------------------IVHSSEILNSTTS-VYIIENGIRKRMKAD--------ENILPRQPPLSP----KSNRLMGKRIQ-------------------------NPLNIEPEADELTPLPRNYKIESS-HNPHRKLEGSLPDVSY--------CNEI-KTKTGTL-----MSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHIL 3133
LV+ +T Y +N+Q + N+ I +E+ + E + T L RRR++PSIMT P+ A + ++ P+ + + VHS+E L + + YIIENGIRKR++A+ N + P SP ++N G R + N + +PE +L+PLP++Y IES H P E S+PD+S C+ K +TG ++R+E ++LSQ RRQEI HE ER++RGEIVIR+ADIKDW + NF IV +LL+N +A F ++L
Sbjct: 740 LVQPLETHRAHISYVNNSQTHNYQQLEVNINGQFNNDEAIGDNWEQESVLSKEPVSPSGTILTAVSKVRRRTLPSIMTEPPIQTTRNACNKAGLQLPNTRINSTTKGSTHNSNLGCIIDDQTVHSAENLPADAADTYIIENGIRKRVQAETHHRQQNQRNRITTGPTGSPIKASENNYSEGSRPEWTTAYDPYRPAMENTGVVTANRYGINNQHSDPETSDLSPLPKSYLIESIIHLPGDVKEASMPDISMTHGHASGQCDSSSKRRTGQYPVSGELTREEIARLSQARRQEIYHEMERRKRGEIVIRLADIKDWIRANFVIVFVLLINASLAFFFFNLL 1079
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Match: jph1b (junctophilin-1 [Source:NCBI gene;Acc:103024555]) HSP 1 Score: 318.161 bits (814), Expect = 7.574e-95 Identity = 191/446 (42.83%), Postives = 274/446 (61.43%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRK-ALF---RKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLP----IPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIE 1774
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KG+W+Y+GE+T GF GRYGV++SL++ +++EG+W L DG+GVET DG TY G W G+R G GVR+S Y A + P +S+R+ S S+L +D P R GFVL ++++++ KK FR+ +LF ++LRK S + S R +T+S S++ + S + P +++D E Y G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+GT+EEG+YK NVLV+ + K ++ L++++ K V+ AV+ A+ AAA AK + ++ A A+ E A+ + A + S+ AR VA++ +P+F Q G ++K R + E
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYSGSWSSGFEVVGVYTWPSGNTYQGHWAQGKRHGLGVESKGRWLYRGEWTHGFKGRYGVRQSLNTPARYEGTWSNGLQDGYGVETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIRSPLRTSLASLRSEQSNGSVLHERLTD---------SPAGTRGGFVL-NFHSDSELGGPARKKGLFRRGSLFGSLKQLRKSDSRSSISSKRSSARSDATMSRISSSDANSTISFGEGEGADEYTPMEDNVDATTTEAYMGEWKNDKRNGFGVSERSNGMKYEGEWTNNKRHGYGCTMFPDGTREEGKYKNNVLVRGIKK--QLIPLKNTKTKQKVDRAVEGAIRAAAIAKTKVEIATSRTAH-ARAKGEAADQASLSACQNSDVARAVARDLSPNFHQPGPDYIKQRFSSE 433
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Match: jph3 (junctophilin 3 [Source:NCBI gene;Acc:103038422]) HSP 1 Score: 317.005 bits (811), Expect = 7.025e-94 Identity = 205/495 (41.41%), Postives = 287/495 (57.98%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDAR----RPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSL-----PIPS-RESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQL--GVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDP 1906
GGRF+FDDGGSY G W +G+AHG GI TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+ES ++ K+EG+W+ L DG+G ET +DG TY G W G+R G G+R+S Y AA + P +S+R+ S + L A + P R GFVL T ++ A++ K+ K FR++L KLRK +S L S R S RS ++ +S A++ + SL +P+ E +D E+Y+G+WK DKR G GV+ R+DG Y+GEW NK+ GYG T FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A +AA AK+++ ++ A A+ AE A A++AQ+ AR AKEF+P F GV + ++ + G V+ + D Y+ + P + P PS P
Sbjct: 4 GGRFNFDDGGSYCGGWEEGKAHGHGICTGPKGQGEYAGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLENKGKWVYKGEWTHGFKGRYGVRESTGASGKYEGTWNNGLQDGYGTETYSDGGTYQGQWVGGMRHGYGIRQSVPYGMAAVIRSPLRTSINSLRSEHSNGTALLAGERAGVGPGVGPGSLVASPAVSRGGFVL-TAHSEAELLKGKKNKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSAASDINSTISLGEGESELPAGEEDVDATATESYAGEWKNDKRTGCGVSRRSDGLCYQGEWMGNKRHGYGCTTFPDGTKEEGKYKQNVLVSG--KRKHLIPLRASKIREKVDRAVEGAEKAADIAKQKSEIALSRTAH-ARGKAEAAIAAAQKAQEECRLARVAAKEFSPSFQHRGNGVECQRPKHQHSSENDGEVISSGTPDSTD--LYMKGSTPPDLTPDISPVPSRPSTP 492
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Match: si:ch211-146m13.3 (junctophilin-3-like [Source:NCBI gene;Acc:103045469]) HSP 1 Score: 316.235 bits (809), Expect = 1.585e-93 Identity = 190/430 (44.19%), Postives = 261/430 (60.70%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP--SSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDL------RSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLG 1741
GGRFDFDDGGSY G W G+AHG G+ TGP+ QGE++G W GFE G Y WPSGN Y G W +GKRHG GV+ KG+W YKGE+T GF GRYG ES S +++EG+W L DG+G ET +DG T+ G W G+R G GVR+S Y AA P +S+ + S++S + D A A P+ R GFVL +D +++K FR+++ KLR+ +S L +S+ + ST+SS +A+ +N SL D + S+D V ETY G+W+ D R G+G++ R+DG +YEGEWF NK+ GYG T FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A +AA AK+++ + R A+ AE AE A+ A + AR +AKE +P F G
Sbjct: 4 GGRFDFDDGGSYCGGWEQGKAHGQGVCTGPQGQGEYAGAWSHGFEVLGAYTWPSGNSYQGTWAQGKRHGIGVETKGRWEYKGEWTQGFKGRYGRLESTGSGARYEGTWSNGLQDGYGSETYSDGGTFQGQWLSGMRHGYGVRQSVPYGMAAVIFSPLRTSINSLRSEHSEGAPKPDDGSAVSGVAGSPVG-RGGFVLCA---QSDAERQRKRKGRFRQSILSGLKLRRSESKSSLASQLSKQSSFCSEAGMSTVSS-AASDINSNVSLGD---VEMGGSVDATVTETYVGEWRNDMRTGWGISHRSDGLRYEGEWFGNKRHGYGCTTFPDGTKEEGKYKQNVLVSG--KRKNLIPLRTSKIREKVDRAVEAAEKAAEIAKQKSEIALS-RTSHARGKAEAAEGVAQRALEECRLARIIAKELSPSFHHYG 422
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Match: jph1a (junctophilin-1-like [Source:NCBI gene;Acc:103033137]) HSP 1 Score: 314.309 bits (804), Expect = 1.588e-93 Identity = 184/433 (42.49%), Postives = 264/433 (60.97%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSF--RKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLP--IPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG GV+ KG+W+Y+GE++ GF GRYGV++ ++ ++++G+W L DG+GVET ADG TY G W G+R G GVR+S Y A + P TS SL S + +P+ R GFVL ++ A+ A +KKP R +LF LR+ + + S S + S+S + + ++ ++ +P +++D ETY G+WK DKR G+G++ER++G KYEGEW NNK++GYG T FP+GT+EEG+YK NVLV+ + R +I L++ + K+ VE AV+ A AA A+ + + R A+ +E A+ A A S+ AR VA+E +P F Q G ++K +
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPQGQGEYAGAWSHGFEIVGVYTWPSGNTYQGYWSQGKRHGLGVETKGRWMYRGEWSHGFKGRYGVRQGSNTPARYDGTWSNGLQDGYGVETYADGGTYQGQWMGGMRHGYGVRQSVPYGMAMVIRSP----LRTSLASLRSVQSNGVVMPDTTGEQPVSTRGGFVL-NFHSEAEAQAGGKKKPGLFRRGSLFGSLRQLRKSESKSSISSKRSSAMSRISSSDGNSSISYGEGEAQEEFLPMEDNVDATTTETYMGEWKNDKRNGFGISERSNGMKYEGEWLNNKRNGYGCTIFPDGTREEGKYKNNVLVRGI--RKQIIPLKNPKTKEKVERAVEGARRGAAIARMKVEIATS-RTTHARAKSEAADQAAVAAGHESDLARAVARELSPSFHQPGPDYIKQK 425
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Match: jph3 (junctophilin 3 [Source:NCBI gene;Acc:103038422]) HSP 1 Score: 317.39 bits (812), Expect = 3.484e-93 Identity = 205/495 (41.41%), Postives = 287/495 (57.98%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFVDDAR----RPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRSTLSSNSAASQATNHSLPDSL-----PIPS-RESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQL--GVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDP 1906
GGRF+FDDGGSY G W +G+AHG GI TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG G++ KGKW+YKGE+T GF GRYGV+ES ++ K+EG+W+ L DG+G ET +DG TY G W G+R G G+R+S Y AA + P +S+R+ S + L A + P R GFVL T ++ A++ K+ K FR++L KLRK +S L S R S RS ++ +S A++ + SL +P+ E +D E+Y+G+WK DKR G GV+ R+DG Y+GEW NK+ GYG T FP+GTKEEG+YK+NVLV KR + LR S++++ V+ AV+ A +AA AK+++ ++ A A+ AE A A++AQ+ AR AKEF+P F GV + ++ + G V+ + D Y+ + P + P PS P
Sbjct: 4 GGRFNFDDGGSYCGGWEEGKAHGHGICTGPKGQGEYAGSWSHGFEVLGVYTWPSGNTYQGTWAQGKRHGIGLENKGKWVYKGEWTHGFKGRYGVRESTGASGKYEGTWNNGLQDGYGTETYSDGGTYQGQWVGGMRHGYGIRQSVPYGMAAVIRSPLRTSINSLRSEHSNGTALLAGERAGVGPGVGPGSLVASPAVSRGGFVL-TAHSEAELLKGKKNKGLFRRSLLSGLKLRKSESKSSLASQRSKQSSFRSEAGMSTVSSAASDINSTISLGEGESELPAGEEDVDATATESYAGEWKNDKRTGCGVSRRSDGLCYQGEWMGNKRHGYGCTTFPDGTKEEGKYKQNVLVSG--KRKHLIPLRASKIREKVDRAVEGAEKAADIAKQKSEIALSRTAH-ARGKAEAAIAAAQKAQEECRLARVAAKEFSPSFQHRGNGVECQRPKHQHSSENDGEVISSGTPDSTD--LYMKGSTPPDLTPDISPVPSRPSTP 492
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009496.1 (pep scaffold:Pmarinus_7.0:GL480437:14153:18284:1 gene:ENSPMAG00000008588.1 transcript:ENSPMAT00000009496.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 120.553 bits (301), Expect = 2.471e-30 Identity = 84/257 (32.68%), Postives = 131/257 (50.97%), Query Frame = 2
Query: 857 TYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLLSANDSDRQAFV---DDARRPIDHRSGFVLVTTNNN-----------ADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSS-------NSAASQATNHSL----PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLK 1537
TY G W+ G+R G GVR S Y A+ + P SS+R+ + S++ + DDA + R GFVL +++ ++ S +L K R+ S L S R S RS+ S +SAAS T+ ++ P++ S + ++ N ETY+G+WK DKR+G+GV++R+DG +YEGEW N+++GYG T +P+G EEG+Y++ L T KR + LR S+ +
Sbjct: 2 TYQGQWAGGMRHGYGVRNSVPYGLASVVRSPLRTSLSSLRSEQTNGSIVGPVGGGAGGSLRSGDDAGSAVGSRGGFVLTGVHHSDSEQQGGKAGGKRGGGGLFRRGSLLGSL--KFRRSDSKASLSSER---SKRSSFRSEAGMSAISSAASDGTSLAVSLGEPETELFDSEDLVEANTTETYTGEWKGDKRSGFGVSQRSDGLRYEGEWLANRRNGYGRTSYPDGRSEEGKYRQGTL--TRGKRRSLVPLRASKTR 251
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Match: RSPH10B2 (radial spoke head 10 homolog B2 [Source:HGNC Symbol;Acc:HGNC:34385]) HSP 1 Score: 57.7658 bits (138), Expect = 1.083e-8 Identity = 44/149 (29.53%), Postives = 59/149 (39.60%), Query Frame = 2
Query: 497 FDDGGSYVGEWCDGRAHGLG---IATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEG--------VQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRK 910
++ G Y G +C+ HG G A G E +G+F W+ G Y WP G+ Y G G RHG+G V G W G V S + G WH N+ G+G+ G+ Y G W R G G +
Sbjct: 2 YEGGNVYSGSFCNNMMHGKGKYVWADGVEFEGDF---WLNAMVGHGTYQWPDGSKYTGNVENGVRHGQGTLTVSKPFVSYSGHWYASERHGKGI-----VYYDEKRESWYCGEWHHNMRHGWGIRRYPSGNIYEGQWLNNERHGEGCMR 142 HSP 2 Score: 50.8322 bits (120), Expect = 1.382e-6 Identity = 44/148 (29.73%), Postives = 60/148 (40.54%), Query Frame = 2
Query: 512 SYVGEWCDGRAHGLGIATGPEN-QGEFSGEWVMGF-ESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWI-----YKGEFTTG----------FCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGV 904
SY G W HG GI E + + GEW G+ +PSGNIY G W+ +RHGEG +WI Y G++ G R G + +++ G W G G A G+ Y G W + + G G
Sbjct: 77 SYSGHWYASERHGKGIVYYDEKRESWYCGEWHHNMRHGWGIRRYPSGNIYEGQWLNNERHGEGCM---RWITLMQEYNGQWKHGKPDGRGAHKWLVKRVGCSQ-YPMCNEYHGEWAAGHRHGQGEFLYASGAQYKGEWRQDRKHGSGT 220
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Match: RSPH10B2 (radial spoke head 10 homolog B2 [Source:HGNC Symbol;Acc:HGNC:34385]) HSP 1 Score: 51.9878 bits (123), Expect = 5.995e-7 Identity = 44/148 (29.73%), Postives = 60/148 (40.54%), Query Frame = 2
Query: 512 SYVGEWCDGRAHGLGIATGPEN-QGEFSGEWVMGFES-RGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWI-----YKGEFTTG----------FCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGV 904
SY G W HG GI E + + GEW G+ +PSGNIY G W+ +RHGEG +WI Y G++ G R G + +++ G W G G A G+ Y G W + + G G
Sbjct: 38 SYSGHWYASERHGKGIVYYDEKRESWYCGEWHHNMRHGWGIRRYPSGNIYEGQWLNNERHGEGCM---RWITLMQEYNGQWKHGKPDGRGAHKWLVKRVGCSQ-YPMCNEYHGEWAAGHRHGQGEFLYASGAQYKGEWRQDRKHGSGT 181
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003398.1 (pep scaffold:Pmarinus_7.0:GL476560:333524:339285:-1 gene:ENSPMAG00000003108.1 transcript:ENSPMAT00000003398.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 48.521 bits (114), Expect = 9.342e-7 Identity = 23/55 (41.82%), Postives = 32/55 (58.18%), Query Frame = 2
Query: 1307 ETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKE 1471
E Y G+WKE +R G G TDG Y G++ N G GV FP+G++ EG + +
Sbjct: 14 EEYQGEWKEGRRHGLGQLRFTDGTHYLGQFENGLFSGCGVLAFPDGSRFEGEFSQ 68 HSP 2 Score: 46.595 bits (109), Expect = 3.402e-6 Identity = 30/96 (31.25%), Postives = 48/96 (50.00%), Query Frame = 2
Query: 620 RGVYIWPSGNIYAGGWMKGKRHGEG-VQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGV 904
+G + + +G Y G W +G+RHG G ++ Y G+F G GV + S+FEG + F G GV + +DG + G + G +G G+
Sbjct: 5 KGSFTYATGEEYQGEWKEGRRHGLGQLRFTDGTHYLGQFENGLFSGCGVL-AFPDGSRFEGEFSQGKFHGVGVFSRSDGMMFEGEFKNGHVEGYGL 99 HSP 3 Score: 46.2098 bits (108), Expect = 4.620e-6 Identity = 35/103 (33.98%), Postives = 52/103 (50.49%), Query Frame = 2
Query: 467 MSVIEGGRFDFDDGGSYVGEWCDGRAHGLG---IATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGK-WIYKGEFTTGFCGRYGV 763
M++++G F + G Y GEW +GR HGLG G G+F F GV +P G+ + G + +GK HG GV + +++GEF G YG+
Sbjct: 1 MTLMKG-SFTYATGEEYQGEWKEGRRHGLGQLRFTDGTHYLGQFENGL---FSGCGVLAFPDGSRFEGEFSQGKFHGVGVFSRSDGMMFEGEFKNGHVEGYGL 99
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000001977.1 (pep scaffold:Pmarinus_7.0:GL478223:216506:238429:-1 gene:ENSPMAG00000001779.1 transcript:ENSPMAT00000001977.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 50.8322 bits (120), Expect = 2.253e-6 Identity = 41/137 (29.93%), Postives = 52/137 (37.96%), Query Frame = 2
Query: 506 GGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSA 916
G Y G+WCDG+ HG G T WP G Y G + G HG GK+ T G KE K+ G W +G+G+ +ADG Y G GVR G G+ S+
Sbjct: 1042 GAHYYGQWCDGKPHGWGRMT-----------------------WPDGRTYIGNFKFGSEHG-----YGKYTVANAST-------GKKE------KYCGEWREGKINGYGLYKHADGEVYEGYLVGGVRHGHGMLLSS 1137
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Match: EDO41562 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3X5]) HSP 1 Score: 222.246 bits (565), Expect = 5.542e-64 Identity = 129/349 (36.96%), Postives = 183/349 (52.44%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSV-RAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFAL 1519
+ GGRFDF+DGG+Y GEW +G+AHG GI TGP+ Q + G W GFE GVY+WP+G+ Y G W GKRHG GV+ +GKWIY+GE+ GF RYGV+ S S A ++EGSW L +G+G+E A+G Y G W G+R G G+R + K S+ R + ++++ + RQ P +SG +N +N+ + G + GSL ST+ A + P++ P+ V E Y G WK DKR GYG+ E +DG KY G+W N + G GV +P+ +K EG ++ + LV + K+ I L
Sbjct: 1 MSGGRFDFEDGGTYCGEWRNGKAHGYGICTGPKGQARYEGSWHNGFELSGVYVWPNGHRYEGEWYCGKRHGLGVEYRGKWIYQGEWEDGFKARYGVQRSQSGA-RYEGSWTSGLQEGYGIEVYANGGYYYGQWKTGMRSGYGIRSAKRDPKVTITNYARSISRQSNAESNGVIPTKQKRQGGELPPAEPHSPKSGSESDNASNTGSVNS--------------------TVGSGSTQLADGSLDSTV--------AVTQTEPEAEPVKP-------VRELYKGDWKNDKRHGYGILEASDGYKYIGQWHENMRHGLGVACYPDSSKYEGEFENDNLVVDIKKKGPIKTL 313
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Match: EDO49962 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RER8]) HSP 1 Score: 55.8398 bits (133), Expect = 3.491e-8 Identity = 39/134 (29.10%), Postives = 64/134 (47.76%), Query Frame = 2
Query: 503 DGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMG-FESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLG 901
+G Y G+W + + HG+G P+ + GEW + RG I+P+ + Y G W + R G+G+ + IY+G+F +G+ + S+++G W + G G+TY G W R GLG
Sbjct: 151 NGALYKGQWENSQRHGVGTYEAPDGT-MYEGEWSADHIQGRGRMIYPNKDSYDGSWFRNMRFGKGIYCFHEGIYEGQFEYDLRHGHGLMR-YNDGSEYDGEWQNDQVKSLGSMDYLGGATYDGPWELDRRHGLG 282 HSP 2 Score: 49.6766 bits (117), Expect = 3.689e-6 Identity = 71/293 (24.23%), Postives = 114/293 (38.91%), Query Frame = 2
Query: 485 GRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMG-FESRGVYIWPSGNIYAGGWMKGKRHGEG-VQMKGKWIYKGEFTTG-FCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYG 1354
G + +G Y GEW +G HG G+ N+ G +V G +S G +G Y G W K K+HG+G + M Y G F CG G + + ++G W + G G DG+ Y G WS QG R Y ++ D S R + ++ + + + D R G L+ N+ ++ + + + KS G + +GG+ + + H L RE++ + Y G+WKED++ G G
Sbjct: 52 GTLKYPNGDYYHGEWREGEMHGKGVIV-FNNKDSLEGVFVKGDIQSEGTLKCTNGLTYVGTWHKSKKHGKGRLVMANGDTYNGNFVNDRMCGE-GEMLYAKNGALYKGQWENSQRHGVGTYEAPDGTMYEGEWSADHIQG---RGRMIYPNKDSY-DGSWFRNMRFGKGIYCFHEG-----IYEGQFEYDLRHGHGLMRYNDGSEYDGEWQND------------QVKSLGSM--DYLGGA-----TYDGPWELDRRHGL-------GRETLKCGTV--YEGRWKEDRKCGEG 305
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Match: EDO43658 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RY90]) HSP 1 Score: 55.0694 bits (131), Expect = 8.011e-8 Identity = 43/151 (28.48%), Postives = 62/151 (41.06%), Query Frame = 2
Query: 485 GRFDFDDGGSYVGEWCDGRAHGLGIAT----GPENQGEFSGEWVMG-FESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKW------IYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGV 904
G + D Y+GE+ G HG G+ P+N + GEW G G + G+ Y G W RHG GV G +Y GE++ YG + + K+ G W ++ G GV DG G + +G G G+
Sbjct: 11 GEMRWPDKRVYMGEFKQGEHHGHGVMVFPPNSPDNADRYEGEWSHGKISGFGKMKYMHGDTYTGHWRDNTRHGHGVMSYGAMSSSAASVYIGEWSADRKNGYGTMDDVIRGEKYMGMWDNDIRQGAGVIVTLDGVYTQGTFVQGKLTGHGL 161 HSP 2 Score: 50.0618 bits (118), Expect = 3.102e-6 Identity = 34/95 (35.79%), Postives = 44/95 (46.32%), Query Frame = 2
Query: 665 WMKGKRHGEG-VQMKGKWIYKGEFTTGFCGRYGVK----ESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAA 934
W+ GK HG G ++ K +Y GEF G +GV S +A ++EG W GFG G TY+G W R G GV A S +A
Sbjct: 2 WLTGKPHGHGEMRWPDKRVYMGEFKQGEHHGHGVMVFPPNSPDNADRYEGEWSHGKISGFGKMKYMHGDTYTGHWRDNTRHGHGVMSYGAMSSSA 96
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Match: EDO41170 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S530]) HSP 1 Score: 53.1434 bits (126), Expect = 1.462e-7 Identity = 24/58 (41.38%), Postives = 38/58 (65.52%), Query Frame = 2
Query: 1304 IETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENV 1477
E Y G+W DKR+G+G +DGA YEGEW+++K++G G+ N + EG +K+ +
Sbjct: 109 TEYYEGEWYADKRSGWGRMYYSDGAVYEGEWYDDKQNGEGMLRLANENRYEGEWKDGL 166
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Match: EDO27248 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T9S6]) HSP 1 Score: 50.8322 bits (120), Expect = 3.921e-7 Identity = 24/56 (42.86%), Postives = 37/56 (66.07%), Query Frame = 2
Query: 1307 ETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKEN 1474
+TY G + KR GYG+ + A+YEGE+ NNK++G G +FP+G+ +G +K N
Sbjct: 25 DTYQGLYNNGKRHGYGIYRFVNKARYEGEYVNNKREGTGTMYFPDGSMYKGEWKNN 80
BLAST of Junctophilin-1 vs. Ensembl Medaka
Match: jph1a (junctophilin 1 [Source:NCBI gene;Acc:101173340]) HSP 1 Score: 332.028 bits (850), Expect = 9.583e-100 Identity = 202/490 (41.22%), Postives = 281/490 (57.35%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLS--ANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALF---RKLRKQKSTGDLRSARMGGSLRSTLS------SNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDPEC 1912
+ GGRFDFDDGG+Y G W DG+AHG GI TGP+ QGE++G W GFE GVY WPSGN Y G W +GKRHG GV+ KGKWIY+GE++ GF GRYGV++S ++ +++EG+W L DG+G+ET DG TY G W G+R G GVR+S Y A + P TS SL S +N + Q A P R GFVL ++++++ K+K R +LF R+LRK S + S R +T+S +NS S D L + + +D ETY G+WK DKR G+GV+ER++G KYEGEW NNK+ GYG T FP+ TKEEG+YK NVLV+ + R ++ L++ + K+ V+ AV+ A AAA A+ + A++ A A+ +E AE A A S AR VA+E +P+F Q G ++K + ++ V + S D+ + + P P P P+
Sbjct: 1 MTGGRFDFDDGGTYCGGWEDGKAHGHGICTGPKGQGEYAGSWSHGFEIVGVYTWPSGNTYKGYWSQGKRHGLGVENKGKWIYRGEWSHGFKGRYGVRQSHNTPARYEGTWSNGLQDGYGIETYGDGGTYQGQWMGGMRHGYGVRQSVPYGMATVIRSP----LRTSMASLRSEQSNGTVLQDLSSPADTPTGSRGGFVL-NFHSDSEVVTGKKKGLFRRGSLFGSLRQLRKSDSRTSISSKRSSARSDATMSRISSSDANSTISIGDGELADDDLHL--EDHVDATTTETYMGEWKNDKRNGFGVSERSNGMKYEGEWLNNKRHGYGCTVFPDATKEEGKYKNNVLVRGI--RKQLIPLKNPKTKEKVDRAVEGAQRAAAIARSKVEIAASRTAH-ARTKSEAAEQAAISAVHDSEIARAVARELSPNFYQPGPDYIKQQFKEPVEIKEVPVEKKDPSPKDSPHFYRKGTTPPVSPVASPEATPPPSPDS 480
BLAST of Junctophilin-1 vs. Ensembl Medaka
Match: jph3 (junctophilin 3 [Source:NCBI gene;Acc:101163737]) HSP 1 Score: 320.857 bits (821), Expect = 4.585e-95 Identity = 195/432 (45.14%), Postives = 270/432 (62.50%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSAND-SDRQAFV------DDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRST--LSSNSAASQATNHSL----PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W +G+AHG GI TGP+ QGE+ G W GFE GVY WPSGN Y G W +GKRHG G++ KG+W+YKGE+T GF GRYG++ES ++ K+EG+W+ L DG+G ET +DG T+ G W G+R G GVR+S Y AA + P TS NSL S ++ S+ A V P R GFVL T ++ A++ K K FR+++ KLRK +S L S R S RS +S+ S+A+ N ++ D+ + + +D ETY G+WK DKR G+GV+ R+DG +YEGEW +NK+ GYG T FP+GTKEEG+YK+N+LV KR + LR S++++ V+ AV+ A +AA A+++A ++ A A+ AE A A++AQ+ S AR AK+F+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEEGKAHGYGICTGPKGQGEYCGSWAHGFELLGVYTWPSGNTYQGTWAQGKRHGVGIENKGRWVYKGEWTHGFKGRYGLRESTGTSGKYEGTWNNGLQDGYGTETYSDGGTFQGQWVGGMRHGYGVRQSVPYGMAAVIRSP----LRTSINSLRSGSEHSNGTALVSMCSTGSSGSSPAVSRGGFVL-TAHSEAELLKGKRKSGLFRRSILSGLKLRKSESRSSLASQRSKQSSFRSEAGMSTVSSAASDVNSTISLGDADAELAVADDDVDATTTETYCGEWKNDKRTGFGVSRRSDGLQYEGEWLSNKRHGYGCTTFPDGTKEEGKYKQNILVSG--KRKNLIPLRASKIREKVDRAVEGAQKAADIARQKAEIALSRTAH-AQGKAEAAVAAAQKAQEESRMARVTAKQFSPSF 427
BLAST of Junctophilin-1 vs. Ensembl Medaka
Match: jph3 (junctophilin 3 [Source:NCBI gene;Acc:101163737]) HSP 1 Score: 314.694 bits (805), Expect = 2.522e-92 Identity = 195/453 (43.05%), Postives = 271/453 (59.82%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSAND-SDRQAFVD---------------------------DARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFR--KLRKQKSTGDLRSARMG-GSLRST--LSSNSAASQATNHSL----PDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDF 1729
GGRF+FDDGGSY G W +G+AHG GI TGP+ QGE+ G W GFE GVY WPSGN Y G W +GKRHG G++ KG+W+YKGE+T GF GRYG++ES ++ K+EG+W+ L DG+G ET +DG T+ G W G+R G GVR+S Y AA + P TS NSL S ++ S+ A +D P R GFVL T ++ A++ K K FR+++ KLRK +S L S R S RS +S+ S+A+ N ++ D+ + + +D ETY G+WK DKR G+GV+ R+DG +YEGEW +NK+ GYG T FP+GTKEEG+YK+N+LV KR + LR S++++ V+ AV+ A +AA A+++A ++ A A+ AE A A++AQ+ S AR AK+F+P F
Sbjct: 4 GGRFNFDDGGSYCGGWEEGKAHGYGICTGPKGQGEYCGSWAHGFELLGVYTWPSGNTYQGTWAQGKRHGVGIENKGRWVYKGEWTHGFKGRYGLRESTGTSGKYEGTWNNGLQDGYGTETYSDGGTFQGQWVGGMRHGYGVRQSVPYGMAAVIRSP----LRTSINSLRSGSEHSNGTALLDRTGAIVPGPPTVPGTLTTSVSMCSTGSSGSSPAVSRGGFVL-TAHSEAELLKGKRKSGLFRRSILSGLKLRKSESRSSLASQRSKQSSFRSEAGMSTVSSAASDVNSTISLGDADAELAVADDDVDATTTETYCGEWKNDKRTGFGVSRRSDGLQYEGEWLSNKRHGYGCTTFPDGTKEEGKYKQNILVSG--KRKNLIPLRASKIREKVDRAVEGAQKAADIARQKAEIALSRTAH-AQGKAEAAVAAAQKAQEESRMARVTAKQFSPSF 448
BLAST of Junctophilin-1 vs. Ensembl Medaka
Match: jph2 (junctophilin 2 [Source:NCBI gene;Acc:101175160]) HSP 1 Score: 311.612 bits (797), Expect = 1.470e-91 Identity = 203/451 (45.01%), Postives = 267/451 (59.20%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDP-----SSVRAATSQNSLL--------SANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSF--RKALFRKLRKQKSTGDLRSARMGGS-LR--STLSSNSAASQAT---NHSLPDSLPIPSRES-IDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRF+FDDGG+Y G W G+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KG WIYKGE+T GF GRYG + S+ S +K+EG+W+ L DG+G ET ADG T+ G ++ G+R G GVR+S Y AA + P +S+R+ S ++L + N S + V R GF L D A K KK R +L KL+K S+ L S + S LR S LSSN++ + +T + SL P ES ID E Y G+WK DKR+GYG++ER+ G KYEGEW NN++ GYG T F G KEEG+Y N+LV+ + KR + L+ +++K VE AV+ A AAA AK++A A+ R AK ++ AE A A S+ AR VAKE +P F Q G +LK +
Sbjct: 1 MSGGRFEFDDGGAYCGGWEGGKAHGHGICTGPKGQGEYSGSWNYGFEVVGVYTWPSGNTYEGYWSQGKRHGLGVESKGHWIYKGEWTHGFKGRYGTRVSVGSGAKYEGTWNNGLQDGYGTETYADGGTFQGQFTGGMRHGYGVRQSVPYGMAAVVRSPLRTSLTSLRSEHSNGTVLQQDIPVITTTNTSGEETPVATPTHLGPSRGGFALTL---QVDPEAVKPKKKGLFRRSSLLGKLKKSDSSVSLSSQKSKTSFLRPDSALSSNASDTNSTISGDESLLGVEDFPPVESDIDATTTEVYMGEWKNDKRSGYGISERSSGLKYEGEWLNNQRHGYGCTTFAEGGKEEGKYMNNMLVKAMKKR--MIQLKGNKIKQKVERAVEGAQRAAAIAKQKAEIAAS-RTTHAKAKSDGAEQAAHAANGESSIARLVAKELSPSFYQPGPEYLKKK 445
BLAST of Junctophilin-1 vs. Ensembl Medaka
Match: jph2 (junctophilin 2 [Source:NCBI gene;Acc:101175160]) HSP 1 Score: 310.842 bits (795), Expect = 1.565e-91 Identity = 201/442 (45.48%), Postives = 264/442 (59.73%), Query Frame = 2
Query: 476 IEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVL------VTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGS-LR--STLSSNSAASQAT---NHSLPDSLPIPSRES-IDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTR 1762
+ GGRF+FDDGG+Y G W G+AHG GI TGP+ QGE+SG W GFE GVY WPSGN Y G W +GKRHG GV+ KG WIYKGE+T GF GRYG + S+ S +K+EG+W+ L DG+G ET ADG T+ G ++ G+R G GVR+S Y AA + P TS SL S +H +G VL +TT N ++ K+K R +L KL+K S+ L S + S LR S LSSN++ + +T + SL P ES ID E Y G+WK DKR+GYG++ER+ G KYEGEW NN++ GYG T F G KEEG+Y N+LV+ + KR + L+ +++K VE AV+ A AAA AK++A A+ R AK ++ AE A A S+ AR VAKE +P F Q G +LK +
Sbjct: 1 MSGGRFEFDDGGAYCGGWEGGKAHGHGICTGPKGQGEYSGSWNYGFEVVGVYTWPSGNTYEGYWSQGKRHGLGVESKGHWIYKGEWTHGFKGRYGTRVSVGSGAKYEGTWNNGLQDGYGTETYADGGTFQGQFTGGMRHGYGVRQSVPYGMAAVVRSP----LRTSLTSLRS-----------------EHSNGTVLQQDIPVITTTNTSEAVKPKKKGLFRRSSLLGKLKKSDSSVSLSSQKSKTSFLRPDSALSSNASDTNSTISGDESLLGVEDFPPVESDIDATTTEVYMGEWKNDKRSGYGISERSSGLKYEGEWLNNQRHGYGCTTFAEGGKEEGKYMNNMLVKAMKKR--MIQLKGNKIKQKVERAVEGAQRAAAIAKQKAEIAAS-RTTHAKAKSDGAEQAAHAANGESSIARLVAKELSPSFYQPGPEYLKKK 418
BLAST of Junctophilin-1 vs. Planmine SMEST
Match: SMESG000001306.1 (SMESG000001306.1) HSP 1 Score: 1668.67 bits (4320), Expect = 0.000e+0 Identity = 862/891 (96.75%), Postives = 865/891 (97.08%), Query Frame = 2
Query: 467 MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDPECLEVXXXXXXXXXXXXXXXXXEKRPNSPDPQNQKQTSSSKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTLLTSEPLIQRATATLTRQKAPQKIHSNIINIQPQNPKKEGLHYAIVQSGDVIKPQIAQXXXXXXXXXXXPRNVLVKEFDTGNDFFDYYSNNQNELNDGNFIDYEYEERRKIENEVLESKATRLEERRRSVPSIMTSKPVTANLTSSVKYPDNKYDIVHSSEILNSTTSVYIIENGIRKRMKADENILPRQPPLSPKSNRLMGKRIQNPLNIEPEADELTPLPRNYKIESSHNPHRKLEGSLPDVSYCNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHILKR 3139
MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEW+NNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSVEEAVKNAVEAAADAKERAMETANQRAQTAKN K K DFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDPECLEVSGGSRRGSFRSSFRRSGEKRPNSPDPQNQKQTSSSKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTLLTSEPLIQRATATLTRQKAPQKIHSNIINIQPQNPKKEGLHYAIVQSGDVIKPQIAQIESISSYSEIEPRNVLVKEFDTGNDFFDYYSNNQ+ELNDGNFIDYEYEERRKIENEVLESKATRLEERRRSVPSIMTSKPVTANLTSSVKYPDNKYDIVHSSEILNSTTSVYIIENGIRKRMKADENILPRQPPLSPKSNRL+GKRIQNPLNIEPEADELTPLPRNYKIESSHNPHRKLEGSLPDVSYCNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHILKR
Sbjct: 1 MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWYNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSVEEAVKNAVEAAADAKERAMETANQRAQTAKN-------------KTVQSCTRSGKRICTDFIQLGVLWLKTRNNIEGKLTGSVVFNNNFSLLDNQKYLNQNYKPQQMDQLQPNLLNPSDPECLEVSGGSRRGSFRSSFRRSGEKRPNSPDPQNQKQTSSSKPLSGHNPNSNMTPQKPVASPTNVDCYSFEVPKIGHSVSEVAQQTPTTLLTSEPLIQRATATLTRQKAPQKIHSNIINIQPQNPKKEGLHYAIVQSGDVIKPQIAQIESISSYSEIEPRNVLVKEFDTGNDFFDYYSNNQSELNDGNFIDYEYEERRKIENEVLESKATRLEERRRSVPSIMTSKPVTANLTSSVKYPDNKYDIVHSSEILNSTTSVYIIENGIRKRMKADENILPRQPPLSPKSNRLIGKRIQNPLNIEPEADELTPLPRNYKIESSHNPHRKLEGSLPDVSYCNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHILKR 878
BLAST of Junctophilin-1 vs. Planmine SMEST
Match: SMESG000004402.1 (SMESG000004402.1) HSP 1 Score: 376.326 bits (965), Expect = 1.121e-112 Identity = 229/496 (46.17%), Postives = 297/496 (59.88%), Query Frame = 2
Query: 482 GGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPSGNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLL--SANDSDRQAFVDDARRPIDHRSGFVLVTTNNNADINANKEK------KPSFRKALFRKLRKQKSTG-------------------------DLRSARM------------------GGSLRST--------------LSSNSAASQATNHSLPDSLP-IPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLW-LKTRNN 1768
GG+FDF DGG+Y+GEWCDGRAHG GIATGP NQGE+SG+W +GFE+ GVYIWPSGN+Y G WMKGKRHGEGVQ+ G+W+YKG FTTGF GRYGVK SL + S++EG WHLN FDG+G+ET ADGSTY+G W K R+GLGV SA + A +D R + S S+ +S + D I R+GFVL +N ++ K SF K Q ST D RSAR GSL+ST SS S+ +A ++S +P SI +ETY+GQW E+ R G GVAER+DG KY GEW NNK+ GYG+T FP+ T EEGRYK+NVL+Q L+++ +IF ++HSRLK+ V++ V+ A++ A DAK +A+ETA QRAQTA +A +A+ +A +A+ LS AR +AK+ AP+F Q G +W LK R +
Sbjct: 12 GGKFDFKDGGTYIGEWCDGRAHGFGIATGPNNQGEYSGDWSVGFENCGVYIWPSGNVYEGLWMKGKRHGEGVQVMGRWVYKGSFTTGFFGRYGVKSSLYTQSRYEGCWHLNEFDGYGIETCADGSTYAGMWFKNQRKGLGVSHSAQFGLANDFRDSRDSRPSMSDMSMHFGDCRESSNSIYKDCLANEI--RNGFVLCFHSNKYKSKHHELSEIGNVLKKSFHKHQSSHKSDQTSTPTDQSSKSFKLHKKLLLHLRRKKPILDQRSARSLSRQRTVENNENEFLRNPSGSLKSTNSRDHSNQVASTLPTSSGSSLGKAGSNSFSSVVPGYDILSSIPKETVETYAGQWNENTRTGLGVAERSDGLKYIGEWLNNKRHGYGITCFPDNTIEEGRYKDNVLIQQLNRKSRIFLVKHSRLKNLVDDFVQKALDVAQDAKIKAVETAYQRAQTALAAAISAQARADDARTLSKSARNIAKQIAPNFEQPGPVWELKRRKD 505
BLAST of Junctophilin-1 vs. Planmine SMEST
Match: SMESG000065993.1 (SMESG000065993.1) HSP 1 Score: 226.483 bits (576), Expect = 3.915e-61 Identity = 153/465 (32.90%), Postives = 236/465 (50.75%), Query Frame = 2
Query: 470 SVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESRGVYIWPS--GNIYAGGWMKGKRHGEGVQMKGKWIYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDG---FGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSS---VRAATSQNSL---LSANDSDRQAFVDDARRPIDHRSGFVL------VTTNNNADINANKEKKPSFRKA-----LFRKLRKQK--STGDLRSARMGG-------------SLRSTLSSNSAASQATNHSLPDSLPIPSRESIDPNVIETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKENVLVQTLHKRHKIFALRHSRLKDSXXXXXXXXXXXXXXXXXXXXXXXNQRAQTAKNSAETAEIKAKEAQKLSNHAREVAKEFAPDFIQLGVLWL 1753
S + GR++F D G Y+GEW + +A G+G+ T ++QGEF+G W G E GV++WPS G +Y G W KR G G+ +K WI G+F GF GVK S KFEG + DG FG+ET ADG TY G + G+R+GLGVR S Y + +++AT +NS ++N D+ ++ P + GFVL + INA K+ + +++ +F L K++ +T ++ G S S+L+ N+ S AT + + + ++I P+V ETYSG+W +D+R G+GV ER+DG YEG W NNK+ G+G+T F +G+ EEG+Y+ L+ KR+ IF L HS + A+ + ++ + + + A+ A A++ S R++ KE PD+ Q G+ L
Sbjct: 10 SQLPAGRYEFKDSGIYIGEWLNEKAVGIGLLTKDKSQGEFTGLWNSGSEKCGVFLWPSAPGAMYEGEWANSKRDGYGIFIKEDWIVMGKFQEGFI-TLGVKTKEKSIGKFEGEFE----DGCPVFGMETYADGGTYCGDYKSGLREGLGVRTSIPYGEIFAFLPEEKHLLLKSATDENSTNLSFTSNHVDKNG--SASKLPNKFKCGFVLSGKKSDLLIKKLRHINACKKHQKGLKRSKSLTSIFSALTKKELYNTKNIHKNHFGTISVYSVPGNASPKSFHSSLTFNTIQSIAT-------MDMSAGDTIAPDVFETYSGEWVQDQRHGFGVCERSDGVIYEGGWLNNKRHGFGITKFSDGSFEEGQYQNGKLIFLWTKRNPIFFL-HSFRMGLHIKKSVKQARNASKKAQEKDMDCRKKLTEIRETVKKAKEAAALAREYSLETRQLVKEMYPDYEQPGIRIL 459 HSP 2 Score: 72.0182 bits (175), Expect = 1.940e-12 Identity = 54/200 (27.00%), Postives = 96/200 (48.00%), Query Frame = 2
Query: 2546 RRRSVPSIMTSKPVTANLTSSVKYPDNKYDIVHSSEILNS--TTSVYIIENGIRKRMKADENILPRQPPLSPKSNRLMGKRIQNPLNIEPEADELTPLPRNYKIESSHNPHRKL-EGSLPDVSYCNEIKTKTGTLMSRQEASQLSQQRRQEILHEQERQRRGEIVIRMADIKDWFKQNFTIVLILLLNCVIAVGFLHILK 3136
RR +VP IMT +PV +S+ D+ E NS + ++ +++ GIRKR +SP + R ++ + + D L PLP + S N + L EGSLPDVS TK + R+E +L ++ + I ++++ ++G VIR + DW + + ++++ +N + F+ I+K
Sbjct: 718 RRFTVPEIMTQEPVHPTPVTSILR-----DLQEEVEDENSEFSDTMILMDGGIRKR-------------VSPVPVNNIKSRTESKITLNQPQDGLRPLPMIFNFTSQLNLSKDLQEGSLPDVS-----ATKRMCGIPREEVIRLGEEYQHAIELDKQKLKQGVFVIRFYKLGDWLRDHAVSLVVIFINLCLLYFFIAIIK 894
BLAST of Junctophilin-1 vs. Planmine SMEST
Match: SMESG000039153.1 (SMESG000039153.1) HSP 1 Score: 67.3958 bits (163), Expect = 3.764e-11 Identity = 48/153 (31.37%), Postives = 71/153 (46.41%), Query Frame = 2
Query: 485 GRFD------FDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMG-FESRGVYIWPSGNIYAGGWMKGKRHGEGV-QMKGKWIYKGEFTTGFCGRYG---VKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRK 910
GRF+ F +G + G +C+G HG G + G+++ +G Y W G+ Y G + G RHG G+ + +Y G + G R+G V S +EG W+ N+ +GFG G+TY G W +G R G GV K
Sbjct: 97 GRFEGLGTAFFVNGNIFEGMFCEGTMHGTGRFNWKSTNTSYEGDFLYNEISGKGKYTWQDGSSYEGDVVHGVRHGRGIYKHPSGMMYSGLWVNG--NRHGNGTVNYDTDQRSFYEGDWNKNVIEGFGFRQYRSGNTYEGEWYQGKRHGHGVMK 247
BLAST of Junctophilin-1 vs. Planmine SMEST
Match: SMESG000039917.1 (SMESG000039917.1) HSP 1 Score: 58.5362 bits (140), Expect = 2.946e-8 Identity = 69/252 (27.38%), Postives = 103/252 (40.87%), Query Frame = 2
Query: 506 GGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFESR-GVYIWPSGNIYAGGWMKGKRHGEGVQMKGKW----IYKGEFTTGFCGRYGVKESLSSASKFEGSWHLNLFDGFGVETNADGSTYSGAWSKGVRQGLGVRKSAAYSKAATHKDPSSVRAATSQNSLLSANDSDRQAFVDDARRPIDHRSGFVLVTTNN----------NADINANKEKKPSFRKALFRKLRKQKSTGDLRSARMGGSLRSTLS 1216
G +Y+G D + G G T +++ F G + G ++ G W G+ + G + +RHG G+ KW IY+G F F +G+ S ++FEG+++ N +GFGV +G + G + R G G+ YS H+D +NSLL + + F I S + N N DIN N E S L +L K S L S G +L S S
Sbjct: 17 GSTYIGSIKDNQPCGFGKFTWSDDE-YFEGFYQNGIRNKIGFQKWSDGDTFKGEFFNDRRHGWGIY---KWSNNDIYEGSFYQDFRHGFGIYTS-HEGTRFEGTFYENKREGFGVFYYENGDVFQGLYKDNYRCGPGILH---YSDG--HQDV----GLWHRNSLLKLITKNPEVFT------IQLFSDLIATYANQYTEFSYFNSLNEDININSEY--SLDIVLKYRLTKPGSIRVLDSVISGENLTSDCS 246 HSP 2 Score: 53.5286 bits (127), Expect = 9.657e-7 Identity = 20/56 (35.71%), Postives = 37/56 (66.07%), Query Frame = 2
Query: 1307 ETYSGQWKEDKRAGYGVAERTDGAKYEGEWFNNKKDGYGVTHFPNGTKEEGRYKEN 1474
+ Y G + +D R G+G+ +G ++EG ++ NK++G+GV ++ NG +G YK+N
Sbjct: 87 DIYEGSFYQDFRHGFGIYTSHEGTRFEGTFYENKREGFGVFYYENGDVFQGLYKDN 142 The following BLAST results are available for this feature:
BLAST of Junctophilin-1 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 1
BLAST of Junctophilin-1 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Junctophilin-1 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Junctophilin-1 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Junctophilin-1 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of Junctophilin-1 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Junctophilin-1 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019130 ID=SMED30019130|Name=Junctophilin-1|organism=Schmidtea mediterranea sexual|type=transcript|length=3385bpback to top protein sequence of SMED30019130-orf-1 >SMED30019130-orf-1 ID=SMED30019130-orf-1|Name=SMED30019130-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=892bp MSVIEGGRFDFDDGGSYVGEWCDGRAHGLGIATGPENQGEFSGEWVMGFEback to top Annotated Terms
The following terms have been associated with this transcript:
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