FAD synthase

Overview


Name	FAD synthase
Smed ID	SMED30019100
Length (bp)	1828

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of FAD synthase (SMED30019100) t-SNE clustered cells

Violin plots show distribution of expression levels for FAD synthase (SMED30019100) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of FAD synthase (SMED30019100) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for FAD synthase (SMED30019100) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30019100

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
parenchymal cell	SMED30019100	SMESG000076936.1	dd_Smed_v4_8204_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior side	SMED30019100	SMESG000076936.1	dd_Smed_v4_8204_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
posterior muscle cell	SMED30019100	SMESG000076936.1	dd_Smed_v4_8204_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018

Note: Hover over icons to view figure legend

Homology

[Close]

BLAST of FAD synthase vs. Ensembl Human
Match: FLAD1 (flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671])

HSP 1 Score: 190.274 bits (482), Expect = 6.208e-53
Identity = 103/272 (37.87%), Postives = 153/272 (56.25%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +Y+VK+++++E +  ++     L   + + ++  Y P   E+ASE VY L         KV  AL+ I  +  +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRGYTSLG  +NT+ NP L      G  TY PAYLL  E  ER  R
Sbjct:  223 YYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNL-----QMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSR 489

[Close]

BLAST of FAD synthase vs. Ensembl Human
Match: FLAD1 (flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671])

HSP 1 Score: 189.889 bits (481), Expect = 4.255e-52
Identity = 103/272 (37.87%), Postives = 153/272 (56.25%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +Y+VK+++++E +  ++     L   + + ++  Y P   E+ASE VY L         KV  AL+ I  +  +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRGYTSLG  +NT+ NP L      G  TY PAYLL  E  ER  R
Sbjct:  320 YYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNL-----QMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSR 586

[Close]

BLAST of FAD synthase vs. Ensembl Human
Match: FLAD1 (flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671])

HSP 1 Score: 156.762 bits (395), Expect = 3.247e-41
Identity = 81/229 (35.37%), Postives = 129/229 (56.33%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRG 860
            +Y+VK+++++E +  ++     L   + + ++  Y P   E+ASE VY L         KV  AL+ I  +  +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRG
Sbjct:  223 YYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNL-----QMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRG 446

[Close]

BLAST of FAD synthase vs. Ensembl Human
Match: FLAD1 (flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671])

HSP 1 Score: 123.635 bits (309), Expect = 1.148e-32
Identity = 63/126 (50.00%), Postives = 76/126 (60.32%), Query Frame = 3

Query:  615 LEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRGYTSLG  +NT+ NP L      G  TY PAYLL  E  ER  R
Sbjct:    2 LEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSR 127

[Close]

BLAST of FAD synthase vs. Ensembl Human
Match: FLAD1 (flavin adenine dinucleotide synthetase 1 [Source:HGNC Symbol;Acc:HGNC:24671])

HSP 1 Score: 73.9442 bits (180), Expect = 2.871e-13
Identity = 40/137 (29.20%), Postives = 76/137 (55.47%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNY 587
            +Y+VK+++++E +  ++     L   + + ++  Y P   E+ASE VY L         KV  AL+ I  +  +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y
Sbjct:  320 YYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRY 456

[Close]

BLAST of FAD synthase vs. Ensembl Celegans
Match: flad-1 (Probable FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region [Source:UniProtKB/Swiss-Prot;Acc:Q22017])

HSP 1 Score: 161.384 bits (407), Expect = 5.565e-44
Identity = 91/279 (32.62%), Postives = 141/279 (50.54%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVF------------EKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKK--FSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            F+K K+++E E  + +++    L+ ++   +I  YD   +             KASE     +   K+  A  ++    E+  L ++ ++F GGKDCTVL+HL+   +   Y  ++ I+         F E  +FI  +   Y I       LE+ G +K  L +LK   P I  V MG+++ DPNGK  K     T   WP+   + PI++W Y ++W  L  L +PYC LYD+GYTSLGG DNT+ +P L     +G+  Y PAY L  ++ ER  R
Sbjct:   98 FFKTKLTIETESSETMEAVVTSLRELLAG-HIVYYDSHAWLDIVTKWKAFKKRKASENQIEFI--QKLNEAESIVEEIVEKYPLEQIALSFNGGKDCTVLLHLLRLKVDEKYGPSTPIQGFHIMVEDQFPEATQFIIDAAKFYNI-----QVLEFPGPLKTGLAALKKTRPSIIPVLMGSRATDPNGKYMKTPVEWTDSDWPQVLRVCPILNWTYTDVWHMLRGLCVPYCKLYDQGYTSLGGRDNTVKHPALRIVSSDGREHYLPAYKLHNDAEERCNR 368

[Close]

BLAST of FAD synthase vs. Ensembl Celegans
Match: flad-1 (Probable FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region [Source:UniProtKB/Swiss-Prot;Acc:Q22017])

HSP 1 Score: 161.77 bits (408), Expect = 1.240e-43
Identity = 91/279 (32.62%), Postives = 141/279 (50.54%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVF------------EKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKK--FSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            F+K K+++E E  + +++    L+ ++   +I  YD   +             KASE     +   K+  A  ++    E+  L ++ ++F GGKDCTVL+HL+   +   Y  ++ I+         F E  +FI  +   Y I       LE+ G +K  L +LK   P I  V MG+++ DPNGK  K     T   WP+   + PI++W Y ++W  L  L +PYC LYD+GYTSLGG DNT+ +P L     +G+  Y PAY L  ++ ER  R
Sbjct:  145 FFKTKLTIETESSETMEAVVTSLRELLAG-HIVYYDSHAWLDIVTKWKAFKKRKASENQIEFI--QKLNEAESIVEEIVEKYPLEQIALSFNGGKDCTVLLHLLRLKVDEKYGPSTPIQGFHIMVEDQFPEATQFIIDAAKFYNI-----QVLEFPGPLKTGLAALKKTRPSIIPVLMGSRATDPNGKYMKTPVEWTDSDWPQVLRVCPILNWTYTDVWHMLRGLCVPYCKLYDQGYTSLGGRDNTVKHPALRIVSSDGREHYLPAYKLHNDAEERCNR 415

[Close]

BLAST of FAD synthase vs. Ensembl Celegans
Match: flad-1 (Probable FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region [Source:UniProtKB/Swiss-Prot;Acc:Q22017])

HSP 1 Score: 161.77 bits (408), Expect = 6.278e-43
Identity = 91/279 (32.62%), Postives = 141/279 (50.54%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVF------------EKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKK--FSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            F+K K+++E E  + +++    L+ ++   +I  YD   +             KASE     +   K+  A  ++    E+  L ++ ++F GGKDCTVL+HL+   +   Y  ++ I+         F E  +FI  +   Y I       LE+ G +K  L +LK   P I  V MG+++ DPNGK  K     T   WP+   + PI++W Y ++W  L  L +PYC LYD+GYTSLGG DNT+ +P L     +G+  Y PAY L  ++ ER  R
Sbjct:  237 FFKTKLTIETESSETMEAVVTSLRELLAG-HIVYYDSHAWLDIVTKWKAFKKRKASENQIEFI--QKLNEAESIVEEIVEKYPLEQIALSFNGGKDCTVLLHLLRLKVDEKYGPSTPIQGFHIMVEDQFPEATQFIIDAAKFYNI-----QVLEFPGPLKTGLAALKKTRPSIIPVLMGSRATDPNGKYMKTPVEWTDSDWPQVLRVCPILNWTYTDVWHMLRGLCVPYCKLYDQGYTSLGGRDNTVKHPALRIVSSDGREHYLPAYKLHNDAEERCNR 507

[Close]

BLAST of FAD synthase vs. Ensembl Celegans
Match: flad-1 (Probable FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region [Source:UniProtKB/Swiss-Prot;Acc:Q22017])

HSP 1 Score: 161.77 bits (408), Expect = 6.278e-43
Identity = 91/279 (32.62%), Postives = 141/279 (50.54%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVF------------EKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKK--FSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            F+K K+++E E  + +++    L+ ++   +I  YD   +             KASE     +   K+  A  ++    E+  L ++ ++F GGKDCTVL+HL+   +   Y  ++ I+         F E  +FI  +   Y I       LE+ G +K  L +LK   P I  V MG+++ DPNGK  K     T   WP+   + PI++W Y ++W  L  L +PYC LYD+GYTSLGG DNT+ +P L     +G+  Y PAY L  ++ ER  R
Sbjct:  237 FFKTKLTIETESSETMEAVVTSLRELLAG-HIVYYDSHAWLDIVTKWKAFKKRKASENQIEFI--QKLNEAESIVEEIVEKYPLEQIALSFNGGKDCTVLLHLLRLKVDEKYGPSTPIQGFHIMVEDQFPEATQFIIDAAKFYNI-----QVLEFPGPLKTGLAALKKTRPSIIPVLMGSRATDPNGKYMKTPVEWTDSDWPQVLRVCPILNWTYTDVWHMLRGLCVPYCKLYDQGYTSLGGRDNTVKHPALRIVSSDGREHYLPAYKLHNDAEERCNR 507

[Close]

BLAST of FAD synthase vs. Ensembl Celegans
Match: flad-1 (Probable FAD synthase Molybdenum cofactor biosynthesis protein-like region FAD synthase region [Source:UniProtKB/Swiss-Prot;Acc:Q22017])

HSP 1 Score: 161.77 bits (408), Expect = 6.278e-43
Identity = 91/279 (32.62%), Postives = 141/279 (50.54%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVF------------EKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKK--FSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            F+K K+++E E  + +++    L+ ++   +I  YD   +             KASE     +   K+  A  ++    E+  L ++ ++F GGKDCTVL+HL+   +   Y  ++ I+         F E  +FI  +   Y I       LE+ G +K  L +LK   P I  V MG+++ DPNGK  K     T   WP+   + PI++W Y ++W  L  L +PYC LYD+GYTSLGG DNT+ +P L     +G+  Y PAY L  ++ ER  R
Sbjct:  237 FFKTKLTIETESSETMEAVVTSLRELLAG-HIVYYDSHAWLDIVTKWKAFKKRKASENQIEFI--QKLNEAESIVEEIVEKYPLEQIALSFNGGKDCTVLLHLLRLKVDEKYGPSTPIQGFHIMVEDQFPEATQFIIDAAKFYNI-----QVLEFPGPLKTGLAALKKTRPSIIPVLMGSRATDPNGKYMKTPVEWTDSDWPQVLRVCPILNWTYTDVWHMLRGLCVPYCKLYDQGYTSLGGRDNTVKHPALRIVSSDGREHYLPAYKLHNDAEERCNR 507

[Close]

BLAST of FAD synthase vs. Ensembl Fly
Match: CG4407 (gene:FBgn0030431 transcript:FBtr0073696)

HSP 1 Score: 152.525 bits (384), Expect = 1.882e-41
Identity = 85/264 (32.20%), Postives = 141/264 (53.41%), Query Frame = 3

Query:  240 IQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTD---ENGKST----------YHPAYLLTEESFERIGR 989
            +   SE  K+V   ++IS+   L  E        L   ++   A      T +   + E++  F GGKDCTVL+ L+  Y+++   ++  I  L+ ++  SF E++EF++  + NY++       ++Y G +K  L  + ++ P IKAVF+G+++ DP  +       T   WP    +NP+++W+Y ++W ++   S+PYCSLYDRGYTS+G   NT+PNP L  TD   E G ++          Y PA+ L + + ER GR
Sbjct:   38 MSDRSENSKDVAKGQDISNPMELTAED------RLAIEERQNKAFAFFAETLQIYGVEELIFCFNGGKDCTVLLDLLMRYLRQENISSGDIPMLYIKSGDSFPEIDEFVERCVRNYRV-----QLVQYEGTLKEALTHMSSDMPRIKAVFVGSRNTDPYCQHLAPMQPTDNDWPPMMRLNPLLEWSYHDVWHYIHLNSVPYCSLYDRGYTSIGNRANTVPNPHLRRTDAECECGSNSDAVCSCDLGGYRPAWELQDATMERAGR 290

[Close]

BLAST of FAD synthase vs. Ensembl Fly
Match: CG4407 (gene:FBgn0030431 transcript:FBtr0073695)

HSP 1 Score: 152.91 bits (385), Expect = 2.370e-41
Identity = 85/260 (32.69%), Postives = 140/260 (53.85%), Query Frame = 3

Query:  252 SERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTD---ENGKST----------YHPAYLLTEESFERIGR 989
            SE  K+V   ++IS+   L  E        L   ++   A      T +   + E++  F GGKDCTVL+ L+  Y+++   ++  I  L+ ++  SF E++EF++  + NY++       ++Y G +K  L  + ++ P IKAVF+G+++ DP  +       T   WP    +NP+++W+Y ++W ++   S+PYCSLYDRGYTS+G   NT+PNP L  TD   E G ++          Y PA+ L + + ER GR
Sbjct:   70 SENSKDVAKGQDISNPMELTAED------RLAIEERQNKAFAFFAETLQIYGVEELIFCFNGGKDCTVLLDLLMRYLRQENISSGDIPMLYIKSGDSFPEIDEFVERCVRNYRV-----QLVQYEGTLKEALTHMSSDMPRIKAVFVGSRNTDPYCQHLAPMQPTDNDWPPMMRLNPLLEWSYHDVWHYIHLNSVPYCSLYDRGYTSIGNRANTVPNPHLRRTDAECECGSNSDAVCSCDLGGYRPAWELQDATMERAGR 318

[Close]

BLAST of FAD synthase vs. Ensembl Fly
Match: CG16848 (gene:FBgn0032522 transcript:FBtr0080501)

HSP 1 Score: 132.494 bits (332), Expect = 1.289e-34
Identity = 74/215 (34.42%), Postives = 116/215 (53.95%), Query Frame = 3

Query:  351 HDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNG-KQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDEN-GKSTYHPAYLLTEESFERIGR 989
             DK++   EVI       + NE++++F GGKDCTVL+ ++     R    +  + A++ ++   F+E+E+F+   +  Y +         Y G++K   + L  E  ++KA+F+G + +DP      +   T  GWP    I P+++W+Y +IW +L   ++PYC LYD+GYTSLG   +T  NP LL  DE   K TY PAY L     ER  R
Sbjct:   36 RDKLEYTEEVIKRAMTLYKPNEMMLSFNGGKDCTVLLDIL----ARMTPPSMPLGAVYVKSANPFEELEKFVDDCVQRYGL-----QLRRYEGVLKVAFEQLIAEDSQVKAIFLGCRRSDPESCNLYELEPTNNGWPAMMRIFPLLEWSYHDIWNYLRSNNLPYCCLYDQGYTSLGDRSSTRVNPSLLAYDEKLDKMTYRPAYELENVRLERFNR 241

[Close]

BLAST of FAD synthase vs. Ensembl Zebrafish
Match: flad1 (flavin adenine dinucleotide synthetase 1 [Source:NCBI gene;Acc:445492])

HSP 1 Score: 182.57 bits (462), Expect = 2.713e-50
Identity = 92/265 (34.72%), Postives = 151/265 (56.98%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEK---ASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNN-SMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLL 959
            +++V++ ++ +  + ++ A  +L   + K ++    PLV +    A+++VYSL   +     KV +AL  I    ++  +NE+ + F GGKDCT L+HL YA ++R Y +    ++AL+ R    F E+E F++ ++  Y +           G I+  L  +K   P+++AV MGT+  DP +     F  T  GWP++  +NP+++W Y +IW FL  L +PYC LYD+GYTSLG +DN+  NP L   DE G + Y PAY+L
Sbjct:  230 YHRVRLVLDTDSVEEVERARTQLIEELPKGSVV---PLVTDPISVAAQEVYSLSKSETQLGKKVAAALGTIEMALDKYSVNEICVGFNGGKDCTALLHLYYAALKRRYPDGKDRLKALYIRIVSPFPEMERFLQDTIKRYDL-----ELFSVEGSIRQALNEVKERRPDLRAVLMGTRRTDPYSHTLTPFCPTDPGWPDYMRVNPLLEWTYHDIWSFLRTLYVPYCILYDKGYTSLGSMDNSYRNPSLKMVDERGATRYKPAYML 486

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BLAST of FAD synthase vs. Ensembl Zebrafish
Match: flad1 (flavin adenine dinucleotide synthetase 1 [Source:NCBI gene;Acc:445492])

HSP 1 Score: 182.185 bits (461), Expect = 2.341e-49
Identity = 92/265 (34.72%), Postives = 151/265 (56.98%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEK---ASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNN-SMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLL 959
            +++V++ ++ +  + ++ A  +L   + K ++    PLV +    A+++VYSL   +     KV +AL  I    ++  +NE+ + F GGKDCT L+HL YA ++R Y +    ++AL+ R    F E+E F++ ++  Y +           G I+  L  +K   P+++AV MGT+  DP +     F  T  GWP++  +NP+++W Y +IW FL  L +PYC LYD+GYTSLG +DN+  NP L   DE G + Y PAY+L
Sbjct:  347 YHRVRLVLDTDSVEEVERARTQLIEELPKGSVV---PLVTDPISVAAQEVYSLSKSETQLGKKVAAALGTIEMALDKYSVNEICVGFNGGKDCTALLHLYYAALKRRYPDGKDRLKALYIRIVSPFPEMERFLQDTIKRYDL-----ELFSVEGSIRQALNEVKERRPDLRAVLMGTRRTDPYSHTLTPFCPTDPGWPDYMRVNPLLEWTYHDIWSFLRTLYVPYCILYDKGYTSLGSMDNSYRNPSLKMVDERGATRYKPAYML 603

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BLAST of FAD synthase vs. Ensembl Mouse
Match: Flad1 (flavin adenine dinucleotide synthetase 1 [Source:MGI Symbol;Acc:MGI:2443030])

HSP 1 Score: 191.045 bits (484), Expect = 1.778e-53
Identity = 101/272 (37.13%), Postives = 151/272 (55.51%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +++VK+ +++E ++ ++     L   + + ++  Y P   EKA E VY L         KV  AL+ I     +  L+++ + F GGKDCT L+HL +A +QR + +    ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+ +HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y  IW+FL  L +PYC LYDRGYTSLG  +NT  NP L      G   Y PAYLL  E  ER  R
Sbjct:  225 YFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNL-----QVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSR 491

[Close]

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +++VK+ +++E ++ ++     L   + + ++  Y P   EKA E VY L         KV  AL+ I     +  L+++ + F GGKDCT L+HL +A +QR + +    ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+ +HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y  IW+FL  L +PYC LYDRGYTSLG  +NT  NP L      G   Y PAYLL  E  ER  R
Sbjct:  225 YFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNL-----QVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSR 491

[Close]

BLAST of FAD synthase vs. Ensembl Mouse
Match: Flad1 (flavin adenine dinucleotide synthetase 1 [Source:MGI Symbol;Acc:MGI:2443030])

HSP 1 Score: 191.43 bits (485), Expect = 2.164e-53
Identity = 101/272 (37.13%), Postives = 151/272 (55.51%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +++VK+ +++E ++ ++     L   + + ++  Y P   EKA E VY L         KV  AL+ I     +  L+++ + F GGKDCT L+HL +A +QR + +    ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+ +HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y  IW+FL  L +PYC LYDRGYTSLG  +NT  NP L      G   Y PAYLL  E  ER  R
Sbjct:  225 YFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNL-----QVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSR 491

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BLAST of FAD synthase vs. UniProt/SwissProt
Match: sp|Q8R123|FAD1_MOUSE (FAD synthase OS=Mus musculus OX=10090 GN=Flad1 PE=1 SV=1)

HSP 1 Score: 191.045 bits (484), Expect = 1.244e-52
Identity = 101/272 (37.13%), Postives = 151/272 (55.51%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +++VK+ +++E ++ ++     L   + + ++  Y P   EKA E VY L         KV  AL+ I     +  L+++ + F GGKDCT L+HL +A +QR + +    ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+ +HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y  IW+FL  L +PYC LYDRGYTSLG  +NT  NP L      G   Y PAYLL  E  ER  R
Sbjct:  225 YFQVKLILDSEEKEPLEECLAYLTARLPQGSLVPYQPDAVEKAGEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQLCVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNL-----QVLEAEGNMKQALGELQEKHPQLEAVLMGTRRTDPYSCSLSHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTTQNPALKCLSPGGHPVYRPAYLLENEDEERNSR 491

[Close]

BLAST of FAD synthase vs. UniProt/SwissProt
Match: sp|Q8NFF5|FAD1_HUMAN (FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1 SV=1)

HSP 1 Score: 189.889 bits (481), Expect = 2.043e-51
Identity = 103/272 (37.87%), Postives = 153/272 (56.25%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +Y+VK+++++E +  ++     L   + + ++  Y P   E+ASE VY L         KV  AL+ I  +  +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRGYTSLG  +NT+ NP L      G  TY PAYLL  E  ER  R
Sbjct:  320 YYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNL-----QMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSR 586

[Close]

BLAST of FAD synthase vs. UniProt/SwissProt
Match: sp|Q5RCH4|FAD1_PONAB (FAD synthase OS=Pongo abelii OX=9601 GN=FLAD1 PE=2 SV=1)

HSP 1 Score: 185.267 bits (469), Expect = 1.834e-50
Identity = 102/273 (37.36%), Postives = 152/273 (55.68%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQS-ASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +Y+VK+++++  +++    A   L   + + ++  Y P   E+ASE VY L         KV  AL+ I     +  L ++ + F GGKDCT L+HL +A +QR   +  + ++ L+ R+   F E+E+F++ ++  Y +       LE  G +K  L  L+  HP+++AV MGT+  DP +     FS T  GWP F  INP++DW Y +IW FL  L +PYC LYDRGYTSLG  +NT+ +P L      G  TY PAYLL  E  ER  R
Sbjct:  223 YYQVKLTLDSRGRRIPGGNAWPNLTARLPQGSLVPYMPNAVEQASEAVYKLAESGSSLGKKVAGALQTIETALAQYSLTQLCVGFNGGKDCTALLHLFHAAVQRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNL-----QMLEAEGSMKQALGELQARHPQLEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILYDRGYTSLGSRENTVRDPALKRLSPGGHPTYRPAYLLENEEEERNSR 490

[Close]

BLAST of FAD synthase vs. UniProt/SwissProt
Match: sp|Q68EH8|FAD1_DANRE (FAD synthase OS=Danio rerio OX=7955 GN=flad1 PE=2 SV=1)

HSP 1 Score: 182.57 bits (462), Expect = 2.048e-49
Identity = 92/265 (34.72%), Postives = 151/265 (56.98%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEK---ASEKVYSLVPHD-----KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNN-SMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLL 959
            +++V++ ++ +  + ++ A  +L   + K ++    PLV +    A+++VYSL   +     KV +AL  I    ++  +NE+ + F GGKDCT L+HL YA ++R Y +    ++AL+ R    F E+E F++ ++  Y +           G I+  L  +K   P+++AV MGT+  DP +     F  T  GWP++  +NP+++W Y +IW FL  L +PYC LYD+GYTSLG +DN+  NP L   DE G + Y PAY+L
Sbjct:  230 YHRVRLVLDTDSVEEVERARTQLIEELPKGSVV---PLVTDPISVAAQEVYSLSKSETQLGKKVAAALGTIEMALDKYSVNEICVGFNGGKDCTALLHLYYAALKRRYPDGKDRLKALYIRIVSPFPEMERFLQDTIKRYDL-----ELFSVEGSIRQALNEVKERRPDLRAVLMGTRRTDPYSHTLTPFCPTDPGWPDYMRVNPLLEWTYHDIWSFLRTLYVPYCILYDKGYTSLGSMDNSYRNPSLKMVDERGATRYKPAYML 486

[Close]

BLAST of FAD synthase vs. UniProt/SwissProt
Match: sp|Q6ING7|FLAD1_XENLA (FAD synthase OS=Xenopus laevis OX=8355 GN=flad1 PE=2 SV=1)

HSP 1 Score: 177.948 bits (450), Expect = 8.865e-48
Identity = 92/237 (38.82%), Postives = 136/237 (57.38%), Query Frame = 3

Query:  300 DPLVFEKASEKVYSLVPH-----DKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNN-SMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            DP+   +A+ +VY L        DKV +AL+ +    +   L ++ +AF GGKDCT L+HL +A +QR + +    ++AL+ R    F E+E+F++ +   Y +           G IK  L  LK E P ++AV MGT+ +DP  +       T   WP++  +NP++DW+Y +IW FL  L IPYC LYD+GYTSLG ++NT+ NP L +T   G  +YHPAY L  E  ER+ R
Sbjct:  266 DPVT--QAAAQVYQLAHSGSPLGDKVAAALKTLEEALDTYSLEKICVAFNGGKDCTALLHLFHATVQRKFPDQKDKLQALYIRIVSPFPEMEQFMQSTTKRYNL-----QIYTIQGYIKQALVELKVEQPNLEAVLMGTRRSDPYSRTLTPMCLTDPDWPKYMRVNPLLDWSYRDIWDFLRTLFIPYCILYDKGYTSLGSMENTVKNPALRFTTPAGAESYHPAYKLQNEEEERVSR 495

[Close]

BLAST of FAD synthase vs. TrEMBL
Match: V4BL84 (MoCF_biosynth domain-containing protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_106425 PE=4 SV=1)

HSP 1 Score: 232.261 bits (591), Expect = 1.865e-65
Identity = 115/275 (41.82%), Postives = 175/275 (63.64%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHD-------KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            S++KVK+ +E++ +  + SA E LK+ + + ++  YD      A+EK++ L+  +       K++ +L  I    ER   +E+ + F GGKDCTVL+HL+YA ++R Y + +  +++L+ R++  F EVE+FI+++   Y +     N L Y G IK+C+  LKN+HPEIKAVFMGT++ DP     ++F+ T   WP+F  +NPI++W+Y +IWKFL  L + YCSLYDRGYTSLG ++NT PNP L Y D  G   Y PA+ L +   ER GR
Sbjct:  222 SYFKVKLILESQIEDKLNSACEELKSALPQGSVVKYDENPLIDANEKIHELLKSENGSEFAKKLEKSLHTIEKALERYSFDEICVGFNGGKDCTVLLHLVYAAVKRKYPSIDKKLKSLYIRSKLPFPEVEKFIQIARDRYNL-----NELMYYGRIKDCMGELKNQHPEIKAVFMGTRNTDPYSSHLEEFTMTDADWPQFMRVNPILEWSYDDIWKFLRGLCVSYCSLYDRGYTSLGSMNNTHPNPTLQYIDYRGIVCYKPAHQLQDNQLERDGR 491

[Close]

BLAST of FAD synthase vs. TrEMBL
Match: A0A0B6Z746 (MoCF_biosynth domain-containing protein (Fragment) OS=Arion vulgaris OX=1028688 GN=ORF49376 PE=4 SV=1)

HSP 1 Score: 227.639 bits (579), Expect = 3.299e-63
Identity = 118/276 (42.75%), Postives = 170/276 (61.59%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVP----HDK----VQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPN-GKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            S+YKVK++ E+     +Q A + L + + +  + S+D      A   VY +V     HD+    V+SA+  +  + E  QL E+ I F GGKDCTVL+HL YA +++ Y + N  ++AL+ R+R  F EVE+F++LS   Y +       + Y+G IK CL ++K +HP +KAV MGT+  DP+ G+ K+FS T   WP+F  +NP+++W+Y  +W FL  L +PYCSLYDRGY+SLG +DNT PNP L Y DE G   + PAYLL     ER GR
Sbjct:  269 SYYKVKLTFESVNASDLQEARKELADNLPEGTVVSFDTDPIGSAVSSVYRIVEDSDIHDQYMNCVRSAVATLEQSLETYQLPEICIGFNGGKDCTVLLHLWYAVVKKKYPDYNEKLQALYIRSRCPFPEVEKFVQLSRDRYNL-----QMIHYDGRIKECLATVKVKHPHVKAVIMGTRMMDPHAGQLKEFSLTDPDWPQFMRVNPLLEWHYKHVWFFLRQLCLPYCSLYDRGYSSLGSMDNTHPNPLLQYIDERGVLAFRPAYLLENGEHERDGR 539

[Close]

BLAST of FAD synthase vs. TrEMBL
Match: K1R7T5 (FAD synthetase OS=Crassostrea gigas OX=29159 GN=CGI_10018574 PE=4 SV=1)

HSP 1 Score: 226.098 bits (575), Expect = 3.657e-63
Identity = 116/276 (42.03%), Postives = 167/276 (60.51%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPH--------DKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNY-RNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            ++YKVK+ +E+   + I  A+  LKN +  E+I +YD      A+E+VY LV          + VQ A+ V+    ++  L+E+ I F GGKDCT L+HL +A ++R Y  +   ++AL+ +++  F EVE+F ++S   Y +       L + G IK+ L  LK  HP IKAV MGT+  DP     + FS T   WP+F  +NP++ W+Y  +WKFL DL +PYCSLYDRGYTSLG ++NT PNP L Y DE+G   Y PAY L++ + ER GR
Sbjct:  218 NYYKVKLMLESSNPEQITKAATALKNKLPNESIVNYDSQPIVNAAERVYKLVESCSSDDVYGNNVQKAVSVLEECLQKYSLDEICIGFNGGKDCTALLHLYHAVVKRKYPGHQGKLKALYIKSKLPFPEVEKFTQISRDKYHL-----EMLHFEGRIKDSLGQLKANHPNIKAVIMGTRLTDPYSSHLEAFSMTDADWPQFMRVNPVLHWSYSHVWKFLRDLCLPYCSLYDRGYTSLGSMNNTHPNPLLQYVDEHGVLKYRPAYTLSDPTKERDGR 488

[Close]

BLAST of FAD synthase vs. TrEMBL
Match: A0A1S3JLB7 (FAD synthase isoform X2 OS=Lingula unguis OX=7574 GN=LOC106173914 PE=4 SV=1)

HSP 1 Score: 223.402 bits (568), Expect = 3.229e-62
Identity = 115/271 (42.44%), Postives = 166/271 (61.25%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPH-DKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN---NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            S+YKVK+++EA  +  +  A+  L+ ++ KE +  Y+      A E+VYS       V+S+L V+    E+  L+EV + F GGKDC+ L+HL Y  +++ Y +   ++ ++AL+ R+R  F EVE FI+  +  Y +       L Y+G IK CL  LK + P IKAV MGT+  DP   Q + FS T   WP+F  +NPI+DW+Y +IW+FL  L++PYCSLYD GYTSLG ++NT PNP L Y D+ G + Y PAY L +   ER GR
Sbjct:  218 SYYKVKVTLEATDKGKLDEATYFLQGLLPKEALVKYEKDPLSHAVEEVYSQAETWPTVKSSLRVLEECLEKYSLDEVCVGFNGGKDCSALLHLFYTVVKKKYADQVVDAPLKALYIRSRSPFPEVELFIQQGVDRYGL-----QLLRYDGRIKECLGELKKDCPHIKAVVMGTRRTDPYSVQLEAFSMTDPDWPQFMRVNPILDWSYHDIWRFLRGLNLPYCSLYDIGYTSLGSMENTHPNPALRYIDQFGLAKYRPAYELEQGDLERSGR 483

[Close]

BLAST of FAD synthase vs. TrEMBL
Match: A0A2C9LXT6 (MoCF_biosynth domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106054350 PE=4 SV=1)

HSP 1 Score: 223.402 bits (568), Expect = 1.269e-61
Identity = 112/276 (40.58%), Postives = 166/276 (60.14%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDK--------VQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            S+YKVK+++E+     +Q A + L N +    + SY+      A   VYS++            V+ A++ + +  +R  L+++ I F GGKDCTVL+HL +A  ++ Y +    ++AL+ R+R  F EVE+F+++S   Y ++      + Y+G IK CL +L   HP IKAV MGT+  DP     ++FS T   WP+F  +NP+++W+Y  +W+FL DLS+PYCSLYDRGYTSLG +DNT PNP L Y D  G  TY PA++L     ER GR
Sbjct:  267 SYYKVKLTLESLNPNALQEARKELVNKMPTGTVISYNKDPMGSAVNSVYSILKDTNSTDHYITCVKHAIQTLESALDRYPLSDICIGFNGGKDCTVLLHLFHAVSKKKYPDFQGQLQALYIRSRCPFPEVEKFVQISRDRYNLM-----MIHYDGRIKECLATLALNHPNIKAVIMGTRRTDPCASHLEEFSMTDPDWPQFMRVNPLLEWHYKHVWRFLRDLSLPYCSLYDRGYTSLGSMDNTHPNPLLQYVDARGVLTYKPAHVLENGEHERDGR 537

[Close]

BLAST of FAD synthase vs. Ensembl Cavefish
Match: flad1 (flavin adenine dinucleotide synthetase 1 [Source:NCBI gene;Acc:445492])

HSP 1 Score: 112.464 bits (280), Expect = 1.725e-25
Identity = 60/206 (29.13%), Postives = 111/206 (53.88%), Query Frame = 3

Query:  195 FYKVKISMEAECQQLIQSASERLKNVIGKENISSY--DPLVFEKASEKVYSLVPH-----DKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNY-RNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPII 785
            +++V++ ++++  + ++ A  +L   + K ++     DP+    A+E+VYSL        +KV +AL  I    E+   NE+ + F GGKDCT L+HL +A ++R Y  +   ++AL+ R    F E+E F++ ++  Y +     + +   G I+  L  ++   PE++AV MGT+  DP  +       T  GWPE+  +NP++
Sbjct:  216 YHRVRLVLDSDSAEEVEKARAQLAEELPKGSVVQLITDPVSI--ATEEVYSLANSGSALGEKVSAALRTIETALEQYPANEICVGFNGGKDCTALLHLYHAALRRRYPHSKDKVKALYIRIVSPFPEMERFLQDTIQRYDL-----DLVSVEGSIRQALAEVQERRPELRAVLMGTRRTDPYSRTLTPLCPTDPGWPEYMRVNPLL 414

[Close]

BLAST of FAD synthase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004712.1 (pep scaffold:Pmarinus_7.0:GL478715:25034:33972:1 gene:ENSPMAG00000004289.1 transcript:ENSPMAT00000004712.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 152.91 bits (385), Expect = 3.401e-43
Identity = 78/213 (36.62%), Postives = 116/213 (54.46%), Query Frame = 3

Query:  357 KVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRN-NSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +V  +L+VI        L ++ +AF GGKDCT L+HL++   +R   +    ++AL+ R    F E+E F++ S   Y +           G +++ L  LK   P ++AV MGT+  DP         +T  GWPE+  INP+++W+Y ++W+FL   ++PYC LYD GYTSLG   +T  N  L YTD  G+  Y PAY L +   ER  R
Sbjct:    5 RVADSLKVIEDAVRTYGLAQLCVAFNGGKDCTALLHLVHTVTRRLCLDMGEKLQALYIRGAAPFPEIESFVQESGQRYGL-----RMHTVEGAVRDALAELKLREPGLRAVLMGTRRTDPYSHTLTPECRTDPGWPEYVRINPMLEWSYHDVWRFLRSSNLPYCILYDNGYTSLGSAADTWRNDALRYTDARGEEHYRPAYSLDDPEEERASR 212

[Close]

BLAST of FAD synthase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005475.1 (pep scaffold:Pmarinus_7.0:GL476410:331270:335101:1 gene:ENSPMAG00000004979.1 transcript:ENSPMAT00000005475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 117.087 bits (292), Expect = 7.875e-31
Identity = 63/170 (37.06%), Postives = 87/170 (51.18%), Query Frame = 3

Query:  486 RNYRNN-SMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            R Y+     +  L+ +   +F E+E+FIK +   Y      +    Y G ++  L       P  +AV MG +  DP  +       T  GWP    INP++DW+Y +IW FL  L +PYC LYD+GYTSLG   NT  NP L YT+  G  ++ PAY L + S ER  R
Sbjct:    1 RKYKEQLGTVHCLYIKMPGAFPEMEQFIKETCPRYG-----AESHVYEGDLRTALGEFARCRPRSRAVLMGMRHTDPGPRTLAPMCPTDPGWPPLLRINPLLDWSYHDIWAFLRTLFVPYCILYDKGYTSLGSRKNTRKNPSLCYTNARGVESHRPAYQLEDASHERHSR 165

[Close]

BLAST of FAD synthase vs. Ensembl Yeast
Match: FAD1 (Flavin adenine dinucleotide (FAD) synthetase; performs the second step in synthesis of FAD from riboflavin; mutation is functionally complemented by human FLAD1 [Source:SGD;Acc:S000002203])

HSP 1 Score: 85.1149 bits (209), Expect = 1.159e-18
Identity = 55/184 (29.89%), Postives = 94/184 (51.09%), Query Frame = 3

Query:  414 EVVIAFTGGKDCTVLMHLI------YAYMQRN-------YRNNSMIR--ALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNE---HPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKL 908
            E+  ++ GGKDC VL+ L       Y +++         +++  M R   +F     +F  +E F+  +   Y +   +S     +G   N   + ++    +PE +A+ +G +  DP G+  K   +T   WP+F  + P++ W+   IW FLL  + P C LY +G+TS+GGI+N+LPNP L
Sbjct:   55 EISFSYNGGKDCQVLLLLYLSCLWEYFFIKAQNSQFDFEFQSFPMQRLPTVFIDQEETFPTLENFVLETSERYCLSLYESQ--RQSGASVNMADAFRDFIKIYPETEAIVIGIRHTDPFGEALKPIQRTDSNWPDFMRLQPLLHWDLTNIWSFLLYSNEPICGLYGKGFTSIGGINNSLPNPHL 236

[Close]

BLAST of FAD synthase vs. Ensembl Nematostella
Match: EDO43465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RYI4])

HSP 1 Score: 181.03 bits (458), Expect = 2.169e-50
Identity = 103/270 (38.15%), Postives = 152/270 (56.30%), Query Frame = 3

Query:  198 YKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKV-----QSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDP-NGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            + VK+++E+E Q  +  A + L        ++   P   +K    V  L  H+ +     + A  VI  + +  +L+E+ I+F GGKDCTVL++++YA + ++      I AL+ R    FKE E F++ +   Y +     N +  +G IK  L+ LK  HP IKA+ MGT+ +DP   K   FS T +GWPE+  INPI+DWN+ ++W  LL   +PYC+LYD GYTSLG   NT PNP +L  + N    Y PAYLL ++  ER GR
Sbjct:  226 WHVKLNVESESQAKLHDACQYL--------LTQMPPTCVQK----VEGLNNHEGILGACLKGAWAVIQESLKLFRLDELCISFNGGKDCTVLLYIMYAAVAQSMAEVPKINALYVRHDSPFKEAENFVEETTRLYNL-----NLICMSGKIKPALEELKKSHPNIKAILMGTRRHDPFTEKLHTFSWTDQGWPEYLRINPILDWNHQDVWSILLHCKVPYCTLYDNGYTSLGSSHNTRPNP-VLRVNSN---EYKPAYLLEDDQLERAGR 474

[Close]

BLAST of FAD synthase vs. Ensembl Medaka
Match: ENSORLT00000041422.1 (pep primary_assembly:ASM223467v1:16:18349749:18351299:1 gene:ENSORLG00000026016.1 transcript:ENSORLT00000041422.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 117.857 bits (294), Expect = 7.024e-31
Identity = 56/124 (45.16%), Postives = 74/124 (59.68%), Query Frame = 3

Query:  612 FLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQ-KKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFER 980
             +   G I+  L  ++   PE+KAV MGT+ +DP  +       T  GWP++  +NP++DW Y +IW FL  L +PYC LYD+GYTSLG +DNT  N  L   DE G + Y PAYLL  E  ER
Sbjct:    1 LISVEGSIRQALNEVQERRPELKAVLMGTRRSDPYSQTLAPMCPTDPGWPDYMRVNPLLDWTYHDIWSFLRTLYVPYCILYDKGYTSLGSMDNTHRNTALRMVDEKGVTRYKPAYLLENEEEER 124

[Close]

BLAST of FAD synthase vs. Planmine SMEST
Match: SMESG000076936.1 (SMESG000076936.1)

HSP 1 Score: 557.755 bits (1436), Expect = 0.000e+0
Identity = 265/266 (99.62%), Postives = 266/266 (100.00%), Query Frame = 3

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR
Sbjct:  239 NFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 504

HSP 2 Score: 83.9593 bits (206), Expect = 9.321e-17
Identity = 60/60 (100.00%), Postives = 60/60 (100.00%), Query Frame = 2

Query:   14 MLKYSGYISRKINKFLLLNSNMSXXXXXXXXXXXXXXQVKDENSLYIAQSLPILGLKLKK 193
            MLKYSGYISRKINKFLLLNSNMSNIGLIIIGNEILNGQVKDENSLYIAQSLPILGLKLKK
Sbjct:    1 MLKYSGYISRKINKFLLLNSNMSNIGLIIIGNEILNGQVKDENSLYIAQSLPILGLKLKK 60

[Close]

Query:  192 SFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 989
            +FYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR
Sbjct:  218 NFYKVKISMEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQSALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIRALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNEHPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKFLLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTEESFERIGR 483

The following BLAST results are available for this feature:

BLAST of FAD synthase vs. Ensembl Human
BLAST of FAD synthase vs. Ensembl Celegans
BLAST of FAD synthase vs. Ensembl Fly
BLAST of FAD synthase vs. Ensembl Zebrafish
BLAST of FAD synthase vs. Ensembl Xenopus
BLAST of FAD synthase vs. Ensembl Mouse
BLAST of FAD synthase vs. UniProt/SwissProt
BLAST of FAD synthase vs. TrEMBL
BLAST of FAD synthase vs. Ensembl Cavefish
BLAST of FAD synthase vs. Ensembl Sea Lamprey
BLAST of FAD synthase vs. Ensembl Yeast
BLAST of FAD synthase vs. Ensembl Nematostella
BLAST of FAD synthase vs. Ensembl Medaka
BLAST of FAD synthase vs. Planmine SMEST

BLAST of FAD synthase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
FLAD1	6.208e-53	37.87	flavin adenine dinucleotide synthetase 1 [Source:H...	[more]
FLAD1	4.255e-52	37.87	flavin adenine dinucleotide synthetase 1 [Source:H...	[more]
FLAD1	3.247e-41	35.37	flavin adenine dinucleotide synthetase 1 [Source:H...	[more]
FLAD1	1.148e-32	50.00	flavin adenine dinucleotide synthetase 1 [Source:H...	[more]
FLAD1	2.871e-13	29.20	flavin adenine dinucleotide synthetase 1 [Source:H...	[more]

BLAST of FAD synthase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
flad-1	5.565e-44	32.62	Probable FAD synthase Molybdenum cofactor biosynth...	[more]
flad-1	1.240e-43	32.62	Probable FAD synthase Molybdenum cofactor biosynth...	[more]
flad-1	6.278e-43	32.62	Probable FAD synthase Molybdenum cofactor biosynth...	[more]
flad-1	6.278e-43	32.62	Probable FAD synthase Molybdenum cofactor biosynth...	[more]
flad-1	6.278e-43	32.62	Probable FAD synthase Molybdenum cofactor biosynth...	[more]

BLAST of FAD synthase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 3


Match Name	E-value	Identity	Description
CG4407	1.882e-41	32.20	gene:FBgn0030431 transcript:FBtr0073696	[more]
CG4407	2.370e-41	32.69	gene:FBgn0030431 transcript:FBtr0073695	[more]
CG16848	1.289e-34	34.42	gene:FBgn0032522 transcript:FBtr0080501	[more]

BLAST of FAD synthase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2


Match Name	E-value	Identity	Description
flad1	2.713e-50	34.72	flavin adenine dinucleotide synthetase 1 [Source:N...	[more]
flad1	2.341e-49	34.72	flavin adenine dinucleotide synthetase 1 [Source:N...	[more]

BLAST of FAD synthase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of FAD synthase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 3


Match Name	E-value	Identity	Description
Flad1	1.778e-53	37.13	flavin adenine dinucleotide synthetase 1 [Source:M...	[more]
Flad1	1.778e-53	37.13	flavin adenine dinucleotide synthetase 1 [Source:M...	[more]
Flad1	2.164e-53	37.13	flavin adenine dinucleotide synthetase 1 [Source:M...	[more]

BLAST of FAD synthase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|Q8R123\|FAD1_MOUSE	1.244e-52	37.13	FAD synthase OS=Mus musculus OX=10090 GN=Flad1 PE=...	[more]
sp\|Q8NFF5\|FAD1_HUMAN	2.043e-51	37.87	FAD synthase OS=Homo sapiens OX=9606 GN=FLAD1 PE=1...	[more]
sp\|Q5RCH4\|FAD1_PONAB	1.834e-50	37.36	FAD synthase OS=Pongo abelii OX=9601 GN=FLAD1 PE=2...	[more]
sp\|Q68EH8\|FAD1_DANRE	2.048e-49	34.72	FAD synthase OS=Danio rerio OX=7955 GN=flad1 PE=2 ...	[more]
sp\|Q6ING7\|FLAD1_XENLA	8.865e-48	38.82	FAD synthase OS=Xenopus laevis OX=8355 GN=flad1 PE...	[more]

BLAST of FAD synthase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
V4BL84	1.865e-65	41.82	MoCF_biosynth domain-containing protein OS=Lottia ...	[more]
A0A0B6Z746	3.299e-63	42.75	MoCF_biosynth domain-containing protein (Fragment)...	[more]
K1R7T5	3.657e-63	42.03	FAD synthetase OS=Crassostrea gigas OX=29159 GN=CG...	[more]
A0A1S3JLB7	3.229e-62	42.44	FAD synthase isoform X2 OS=Lingula unguis OX=7574 ...	[more]
A0A2C9LXT6	1.269e-61	40.58	MoCF_biosynth domain-containing protein OS=Biompha...	[more]

BLAST of FAD synthase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1


Match Name	E-value	Identity	Description
flad1	1.725e-25	29.13	flavin adenine dinucleotide synthetase 1 [Source:N...	[more]

BLAST of FAD synthase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 2


Match Name	E-value	Identity	Description
ENSPMAT00000004712.1	3.401e-43	36.62	pep scaffold:Pmarinus_7.0:GL478715:25034:33972:1 g...	[more]
ENSPMAT00000005475.1	7.875e-31	37.06	pep scaffold:Pmarinus_7.0:GL476410:331270:335101:1...	[more]

BLAST of FAD synthase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1


Match Name	E-value	Identity	Description
FAD1	1.159e-18	29.89	Flavin adenine dinucleotide (FAD) synthetase; perf...	[more]

BLAST of FAD synthase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1


Match Name	E-value	Identity	Description
EDO43465	2.169e-50	38.15	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of FAD synthase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1


Match Name	E-value	Identity	Description
ENSORLT00000041422.1	7.024e-31	45.16	pep primary_assembly:ASM223467v1:16:18349749:18351...	[more]

BLAST of FAD synthase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2


Match Name	E-value	Identity	Description
SMESG000076936.1	9.321e-17	99.62	SMESG000076936.1	[more]
SMESG000076936.1	0.000e+0	99.62	SMESG000076936.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30019100 ID=SMED30019100|Name=FAD synthase|organism=Schmidtea mediterranea sexual|type=transcript|length=1828bp
TGAATTTGAATTTATGTTAAAATATTCAGGCTATATATCAAGAAAGATAA
ACAAGTTTCTTTTGCTTAATTCAAACATGAGTAATATAGGACTCATCATA
ATTGGAAATGAAATTCTTAATGGTCAAGTGAAAGATGAAAACAGTTTATA
TATTGCGCAATCTCTACCAATTTTAGGCCTTAAATTAAAGAAGTTTTTAC
AAAGTGAAAATATCAATGGAAGCAGAATGTCAACAACTGATTCAGTCGGC
GTCAGAACGACTGAAAAATGTTATTGGTAAAGAAAATATATCAAGTTATG
ATCCCCTTGTGTTTGAAAAAGCCTCAGAAAAAGTGTACAGCTTAGTACCA
CATGATAAAGTTCAAAGTGCTCTTGAAGTGATTCATGCAACATTTGAACG
GCTTCAATTGAATGAAGTTGTTATTGCTTTCACTGGTGGAAAGGACTGTA
CTGTTTTAATGCATTTAATATATGCGTATATGCAACGGAATTATCGAAAT
AATTCGATGATTCGAGCCTTGTTTTGTCGCACCAGGCCATCATTTAAAGA
AGTTGAGGAATTTATTAAACTTTCTTTGGGAAATTATAAAATAATACCGC
CAAAGTCAAATTTCTTGGAGTACAACGGAATGATAAAAAATTGTCTCCAA
TCTCTCAAAAATGAGCATCCGGAAATTAAAGCAGTATTTATGGGCACCAA
AAGCAATGACCCTAACGGAAAACAGAAGAAGTTTTCTAAAACTACAGAAG
GTTGGCCGGAATTTGAATTGATTAATCCGATTATTGATTGGAATTATTGT
GAAATCTGGAAATTTCTTTTGGATTTGTCAATTCCATATTGTTCACTATA
TGATAGAGGATATACATCACTTGGAGGAATAGACAACACCCTTCCTAATC
CGAAACTCCTGTATACTGACGAAAATGGAAAATCTACATATCATCCGGCT
TATTTATTAACGGAAGAAAGTTTCGAAAGAATCGGTCGCTAAATATTTTA
AAAATTTTAATTATTCAATTTTTTTCGATTCATTTTTCTTTATATAAATT
TTTATATAATTTCCAAAAATATAACTGTTTGGGGTTAAATAAAATTAAGA
CGTAGTAACGGAATTATATATGCAGGACAATTTAAATGTTAAAATATTAT
ACAAAACTCTAAAATAAAATGAAGAGCAAAAATTAAATATAAATTGAGAA
ACGTGGAAATTTATATTTTTACCAGGATGCAAGTAAGCACGTTATAATTG
ATAATGCTATTACAAATACACTAATATAAAATCAAATTTGGCACATAAGC
AAAGTTATTTAAAAAATACAAAATAATTTTTTAATAATTGTAAAATAATA
TTAAAAAAATTAGGAAGAAAATTCCAGTGCTTACATGCTTAAAAAATTCA
AAATTTTGCGGTTTATTGTAAGACAGTTTTCCAAAAAAGCAACTCTAAAT
TCAGTTATATCGCTGTAAATGGTCGAAGAAAAAGGCGATATCAAAAGTGT
TAAGATGAAGCGAGAAAGTTTTAATTAAAATTTATCAGATTCCTACCTCT
AGAATCAAGCAAATTCAATTGTACCGATCAAATTTTAAAAATGGAATTAA
TAAAAGTTATTGTGTTGAGTAATCATTCTAATTTAAAATACATGGAGTCA
GATTTACAATTTTATCTTGTTGAAAGATAAATGGTAACTTAAAATTTTTG
AGGCACTATTAATTCCACGATAGAAATTCATTACCAATGGTGGGTTTCTG
GGTGTCGATATTTTGAAACTATGTGATTATTACCCCGAGAACCCCATACA
AGTATCTTTGCTTACCACTTGTCACCCG

protein sequence of SMED30019100-orf-1

>SMED30019100-orf-1 ID=SMED30019100-orf-1|Name=SMED30019100-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=259bp
MEAECQQLIQSASERLKNVIGKENISSYDPLVFEKASEKVYSLVPHDKVQ
SALEVIHATFERLQLNEVVIAFTGGKDCTVLMHLIYAYMQRNYRNNSMIR
ALFCRTRPSFKEVEEFIKLSLGNYKIIPPKSNFLEYNGMIKNCLQSLKNE
HPEIKAVFMGTKSNDPNGKQKKFSKTTEGWPEFELINPIIDWNYCEIWKF
LLDLSIPYCSLYDRGYTSLGGIDNTLPNPKLLYTDENGKSTYHPAYLLTE
ESFERIGR*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000101	muscle cell
PLANA:0000142	posterior region of the whole animal
PLANA:0003116	parenchymal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001453	MoaB/Mog_dom
IPR014729	Rossmann-like_a/b/a_fold
IPR002500	PAPS_reduct

Vocabulary: **molecular function**
Term	Definition
GO:0003824	catalytic activity

Vocabulary: **biological process**
Term	Definition
GO:0008152	metabolic process

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	GENE3D	G3DSA:3.40.50.620		coord: 23..258 e-value: 2.2E-70 score: 239.2
IPR002500	Phosphoadenosine phosphosulphate reductase	PFAM	PF01507	PAPS_reduct	coord: 68..226 e-value: 5.0E-20 score: 72.3
IPR002500	Phosphoadenosine phosphosulphate reductase	CDD	cd01713	PAPS_reductase	coord: 67..220 e-value: 5.12911E-32 score: 114.039
None	No IPR available	PANTHER	PTHR23293:SF9	FAD SYNTHASE	coord: 46..258
None	No IPR available	PANTHER	PTHR23293	FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE	coord: 46..258
None	No IPR available	SUPERFAMILY	SSF52402	Adenine nucleotide alpha hydrolases-like	coord: 47..215

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FAD synthase

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 3

Owlery

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