DNA repair protein RAD50
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30019011 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 14
Homology
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Match: RAD50 (RAD50 double strand break repair protein [Source:HGNC Symbol;Acc:HGNC:9816]) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 434/1351 (32.12%), Postives = 742/1351 (54.92%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQ----KEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLK-KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVI-------------------KRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ + + R++ TQK +K +TL+ I + +GE +S+SSKCA+I+ EM +SLGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KAL+ +R+++ + +K Y+ ELKYL + A + S+ +L E+ + S + +L+P+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + L+KE+ +E LL E+G + + D I+ A ++ L +++ + R I+++ + + E K NQL+ + E+ K +I +EI K L + K + L +L+ + Y +L ++ + EL Q+L + + + E N++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + + ++ + +++ ++++CG+ D + L +++ K ++ L + ++YS+F L +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L K Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L N + SE L I +LQ L+ Q L E+ SL +++ ++++++P+ L++ E+ + N A+ K++ + K++ I K+ TELNK I L S+ + + + I++ L+ Q I+ K++ R +D L +R E++ ++EE ++ + +L + S+ ++LE+ IK + R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQK--SKKTEFKTLEGVITRT-KHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER--GPFSERQIKNFHKLVRERQEGEAKTA-NQLMNDFAEKETLKQKQI---DEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---------------IAQL-SECEKHKEKINEDMRLMRQ---DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 1306
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Match: AC116366.3 (novel protein) HSP 1 Score: 468.003 bits (1203), Expect = 7.768e-143 Identity = 383/1244 (30.79%), Postives = 668/1244 (53.70%), Query Frame = 1
Query: 385 KNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQ----KEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVI-------------------KRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
K+K +TL+ I + +GE +S+SSKCA+I+ EM +SLGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KAL+ +R+++ + +K Y+ ELKYL + A + S+ +L E+ + S + +L+P+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + L+KE+ +E LL E+G + + D I+ A ++ L +++ + R I+++ + + E K NQL+ + E+ K +I +EI K L + K + L +L+ + Y +L ++ + EL Q+L + + + E N++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + + ++ + +++ ++++CG+ D + L +++ K ++ L + ++YS+F + +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L K Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L N + SE L I +LQ L+ Q L E+ SL +++ ++++++P+ L++ E+ + N A+ K++ + K++ I K+ TELNK I L S+ + + + I++ L+ Q I+ K++ R +D L +R E++ ++EE ++ + +L + S+ ++LE+ IK + R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 6 KSKKTEFKTLEGVITRT-KHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER--GPFSERQIKNFHKLVRERQEGEAKTA-NQLMNDFAEKETLKQKQI---DEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---------------IAQL-SECEKHKEKINEDMRLMRQ---DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 1207
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Match: AC116366.3 (novel protein) HSP 1 Score: 468.003 bits (1203), Expect = 7.768e-143 Identity = 383/1244 (30.79%), Postives = 668/1244 (53.70%), Query Frame = 1
Query: 385 KNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQ----KEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVI-------------------KRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
K+K +TL+ I + +GE +S+SSKCA+I+ EM +SLGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KAL+ +R+++ + +K Y+ ELKYL + A + S+ +L E+ + S + +L+P+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + L+KE+ +E LL E+G + + D I+ A ++ L +++ + R I+++ + + E K NQL+ + E+ K +I +EI K L + K + L +L+ + Y +L ++ + EL Q+L + + + E N++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + + ++ + +++ ++++CG+ D + L +++ K ++ L + ++YS+F + +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L K Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L N + SE L I +LQ L+ Q L E+ SL +++ ++++++P+ L++ E+ + N A+ K++ + K++ I K+ TELNK I L S+ + + + I++ L+ Q I+ K++ R +D L +R E++ ++EE ++ + +L + S+ ++LE+ IK + R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 6 KSKKTEFKTLEGVITRT-KHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER--GPFSERQIKNFHKLVRERQEGEAKTA-NQLMNDFAEKETLKQKQI---DEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---------------IAQL-SECEKHKEKINEDMRLMRQ---DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 1207
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Match: AC116366.3 (novel protein) HSP 1 Score: 468.003 bits (1203), Expect = 7.768e-143 Identity = 383/1244 (30.79%), Postives = 668/1244 (53.70%), Query Frame = 1
Query: 385 KNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQ----KEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVI-------------------KRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
K+K +TL+ I + +GE +S+SSKCA+I+ EM +SLGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KAL+ +R+++ + +K Y+ ELKYL + A + S+ +L E+ + S + +L+P+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + L+KE+ +E LL E+G + + D I+ A ++ L +++ + R I+++ + + E K NQL+ + E+ K +I +EI K L + K + L +L+ + Y +L ++ + EL Q+L + + + E N++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + + ++ + +++ ++++CG+ D + L +++ K ++ L + ++YS+F + +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L K Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L N + SE L I +LQ L+ Q L E+ SL +++ ++++++P+ L++ E+ + N A+ K++ + K++ I K+ TELNK I L S+ + + + I++ L+ Q I+ K++ R +D L +R E++ ++EE ++ + +L + S+ ++LE+ IK + R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 6 KSKKTEFKTLEGVITRT-KHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER--GPFSERQIKNFHKLVRERQEGEAKTA-NQLMNDFAEKETLKQKQI---DEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---------------IAQL-SECEKHKEKINEDMRLMRQ---DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 1207
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Match: RAD50 (RAD50 double strand break repair protein [Source:HGNC Symbol;Acc:HGNC:9816]) HSP 1 Score: 276.174 bits (705), Expect = 9.095e-84 Identity = 141/253 (55.73%), Postives = 186/253 (73.52%), Query Frame = 1
Query: 3259 ERRQIKEQIDSLE-------FRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
E ++++E ID+++ R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 2 EHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 252
BLAST of DNA repair protein RAD50 vs. Ensembl Celegans
Match: rad-50 (DNA repair protein rad-50 [Source:UniProtKB/Swiss-Prot;Acc:O44199]) HSP 1 Score: 183.726 bits (465), Expect = 1.565e-46 Identity = 174/663 (26.24%), Postives = 323/663 (48.72%), Query Frame = 1
Query: 2092 KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLE---------QQLTLSAEEFKIEFEKVTSKKKSIEN----EL-KDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWS----SLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNS---KIQNNL---KAIDDSKSLISQLNFKINNHKVRMREYKDTLQI---RHHGEKIVK-------IEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKD-------LNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEII--------NNRSKQTNFQLIVITHDEEFVNLLS---RSDYV 3924
K+ CPLC R+F+ E+++ ++ + P+E + +S++++ + K + Q++++ +R++ +L+ E+ N ++++ + + +N+ K +++ ++ +K+ E QQL EE + +E++ S+ S + EL K +++K E+ RKI ++ E+ + + E +Q L E SL L+T+++ Q+ +T ++ E + + K L SS + + E +++++K+ EL++ KI H S K+Q + + D ++ I+ LN + ++ R + +++ L+ H E I+K IE I L LA D + ++ E ++ +++ ++ + + +I TQ++ K L+ ++AE+NY + + +L +++ +ISDL KY LD +++ +H KM +N I+ +LWR YN DI I I SD +S S+K+ Y Y V+MV G ++MRGRCSAGQK+LA LLIR+ALAEVF C ++ALDEPTTNLDE + +A L +II N + + + Q++VITHDE VN ++ R +Y+
Sbjct: 661 KSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANEL----QRIVKELK------------------------EVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGE--------ELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKK---ELDQ---------------KIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDA-TSETSSKKVAYEYNVMMV-HETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYI 1267
BLAST of DNA repair protein RAD50 vs. Ensembl Celegans
Match: rad-50 (DNA repair protein rad-50 [Source:UniProtKB/Swiss-Prot;Acc:O44199]) HSP 1 Score: 183.726 bits (465), Expect = 1.565e-46 Identity = 174/663 (26.24%), Postives = 323/663 (48.72%), Query Frame = 1
Query: 2092 KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLE---------QQLTLSAEEFKIEFEKVTSKKKSIEN----EL-KDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWS----SLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNS---KIQNNL---KAIDDSKSLISQLNFKINNHKVRMREYKDTLQI---RHHGEKIVK-------IEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKD-------LNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEII--------NNRSKQTNFQLIVITHDEEFVNLLS---RSDYV 3924
K+ CPLC R+F+ E+++ ++ + P+E + +S++++ + K + Q++++ +R++ +L+ E+ N ++++ + + +N+ K +++ ++ +K+ E QQL EE + +E++ S+ S + EL K +++K E+ RKI ++ E+ + + E +Q L E SL L+T+++ Q+ +T ++ E + + K L SS + + E +++++K+ EL++ KI H S K+Q + + D ++ I+ LN + ++ R + +++ L+ H E I+K IE I L LA D + ++ E ++ +++ ++ + + +I TQ++ K L+ ++AE+NY + + +L +++ +ISDL KY LD +++ +H KM +N I+ +LWR YN DI I I SD +S S+K+ Y Y V+MV G ++MRGRCSAGQK+LA LLIR+ALAEVF C ++ALDEPTTNLDE + +A L +II N + + + Q++VITHDE VN ++ R +Y+
Sbjct: 661 KSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANEL----QRIVKELK------------------------EVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGE--------ELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKK---ELDQ---------------KIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDA-TSETSSKKVAYEYNVMMV-HETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYI 1267
BLAST of DNA repair protein RAD50 vs. Ensembl Celegans
Match: rad-50 (DNA repair protein rad-50 [Source:UniProtKB/Swiss-Prot;Acc:O44199]) HSP 1 Score: 183.341 bits (464), Expect = 2.207e-46 Identity = 174/663 (26.24%), Postives = 323/663 (48.72%), Query Frame = 1
Query: 2092 KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLE---------QQLTLSAEEFKIEFEKVTSKKKSIEN----EL-KDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWS----SLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNS---KIQNNL---KAIDDSKSLISQLNFKINNHKVRMREYKDTLQI---RHHGEKIVK-------IEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKD-------LNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEII--------NNRSKQTNFQLIVITHDEEFVNLLS---RSDYV 3924
K+ CPLC R+F+ E+++ ++ + P+E + +S++++ + K + Q++++ +R++ +L+ E+ N ++++ + + +N+ K +++ ++ +K+ E QQL EE + +E++ S+ S + EL K +++K E+ RKI ++ E+ + + E +Q L E SL L+T+++ Q+ +T ++ E + + K L SS + + E +++++K+ EL++ KI H S K+Q + + D ++ I+ LN + ++ R + +++ L+ H E I+K IE I L LA D + ++ E ++ +++ ++ + + +I TQ++ K L+ ++AE+NY + + +L +++ +ISDL KY LD +++ +H KM +N I+ +LWR YN DI I I SD +S S+K+ Y Y V+MV G ++MRGRCSAGQK+LA LLIR+ALAEVF C ++ALDEPTTNLDE + +A L +II N + + + Q++VITHDE VN ++ R +Y+
Sbjct: 675 KSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANEL----QRIVKELK------------------------EVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGE--------ELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKK---ELDQ---------------KIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDA-TSETSSKKVAYEYNVMMV-HETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYI 1281
BLAST of DNA repair protein RAD50 vs. Ensembl Celegans
Match: rad-50 (DNA repair protein rad-50 [Source:UniProtKB/Swiss-Prot;Acc:O44199]) HSP 1 Score: 183.341 bits (464), Expect = 2.207e-46 Identity = 174/663 (26.24%), Postives = 323/663 (48.72%), Query Frame = 1
Query: 2092 KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLE---------QQLTLSAEEFKIEFEKVTSKKKSIEN----EL-KDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWS----SLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNS---KIQNNL---KAIDDSKSLISQLNFKINNHKVRMREYKDTLQI---RHHGEKIVK-------IEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKD-------LNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEII--------NNRSKQTNFQLIVITHDEEFVNLLS---RSDYV 3924
K+ CPLC R+F+ E+++ ++ + P+E + +S++++ + K + Q++++ +R++ +L+ E+ N ++++ + + +N+ K +++ ++ +K+ E QQL EE + +E++ S+ S + EL K +++K E+ RKI ++ E+ + + E +Q L E SL L+T+++ Q+ +T ++ E + + K L SS + + E +++++K+ EL++ KI H S K+Q + + D ++ I+ LN + ++ R + +++ L+ H E I+K IE I L LA D + ++ E ++ +++ ++ + + +I TQ++ K L+ ++AE+NY + + +L +++ +ISDL KY LD +++ +H KM +N I+ +LWR YN DI I I SD +S S+K+ Y Y V+MV G ++MRGRCSAGQK+LA LLIR+ALAEVF C ++ALDEPTTNLDE + +A L +II N + + + Q++VITHDE VN ++ R +Y+
Sbjct: 675 KSSGCCPLCDRDFKTKKEINEFSKKLENMTLSFPTEQEELEKLVSKLEKEEIIIVKAEGQANEL----QRIVKELK------------------------EVREKNRKLSTEMAEEKSNLSKNEKQLETVNAKLKLAEDLQTDVGVIQQLYEQTEENEKRYEQLVSESDSSDGLSYTELRKKVEDKDEEYRKIVQEGE--------ELQKCSEERNKLQSKLNELGTHRVSLGEAAAQAGAFAEQLETKIKEIQECITAISQKRNEDLPDAQFKKDDLTRNVSSKEEEKKKAEMEVQMMKK---ELDQ---------------KIFHRKSLFKKVQEGGLCERQLMDKENNIATLNASLEENQQRQKRFEEDLRSFDSSHQRESILKDQLTRMIIENKIKELKRTLATFDGQINEDRITEQKQAYNKLQNELRLIGNEEVKIYTQMQEYEKQKKIAEAKLSTKECQNAESNYRDAIIELAITKESISDLTKYRNCLDASLIQFHSEKMGRVNGIIDDLWRKVYNSTDITTIRIRSDA-TSETSSKKVAYEYNVMMV-HETGTEVEMRGRCSAGQKMLASLLIRIALAEVFGGSCSMIALDEPTTNLDESKVEGMAIVLADIIAERRGFDENGKLRGRDMQMVVITHDERLVNRITISCRPEYI 1281
BLAST of DNA repair protein RAD50 vs. Ensembl Fly
Match: rad50 (gene:FBgn0034728 transcript:FBtr0301668) HSP 1 Score: 453.751 bits (1166), Expect = 5.064e-137 Identity = 397/1358 (29.23%), Postives = 703/1358 (51.77%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNN--QFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETI-----SISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQR-EISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEK-GAVDSK-ISEKNNKQHEFDVN------IERFAGEINLSYDKDEADLA------IRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKI-TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRS-------EKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQ--------SKLSGFEFDLKQ---MKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKK---EICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITER-------NSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSL----ISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRR-TYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIK 3975
MS +ES++IQGIRSF + Q +KF PVTLILG NG GKTT++E L YA TG+ P GS G SFVHDPK+ G +EV A++ + ++D +G V+I R +K ++K +NK +S +T+DS+I G++ S+S + DI+V +++ +GVSKA++ NV+FCHQEDS+WPL E+K++KE+FD +F Y KALD I K++ + +K + +K++ + K + QR+ + + + S + +++PI+A + + RN ++ + + Q+ E+ K + QI L I P + EL++ IS+ D +L + Q + E +++ + K + QEK G D K K Q E ++ F E+++ D D + +R+IE I K ++V EK + + KI E+ +++S+ +EK ++ ++ E +G K+ ++ DL +L++++ EV + S + Q + +I + I ++ I K + LV + S +KN + R+RSR +D LF I Y + M + ++KL R +Q KL +++K+ + D + ++L D +E +Y+ C + + L+ + SKL+ + L+SS +LY K+ + + S CPLCH D E DL E+ ++ K P + R L +L +L ++++LK+ + E ++ + + + + IA + + ++N +A+S++GD++ +++ + + K++ + + QL S + + + + ++K + EL+ + +LE + + + N+L + N + +++++ LQ L+ + E L +T++ +++ + K+ P+ L+ I E+ + KL LN SK + Y++ I+R LNK + L N K+ + ++ L+ ++ SL + + + +N + R+ KD +++ +K K+ ES +L+ QL +D ++ + L K+R + + L + I++Q+ + +++++ R K++ N+ + Y+++V+ L I DL +Y AL+ A++ +H KM IN++++E WR Y G DIDYI++ +DE SS AS RR TYNYRVV K N + ++MRGRCSAGQ+VLA L+IRLALAE F +CGVLALDEPTTNLD NI SL +L I+ R Q+NF LI+ITHDE FV+ L + + +Y+R+F + S I+
Sbjct: 1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGKSFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKK-RNK-MSFETMDSTINFLTGAGQSKREKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKALDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKN-CKDQISTLTLKIKKPFRGTLDELDQEISNFDQRMLEMRQKRTEVEGDLSQI--------KRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIIT--------KHCEITEIVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSM-----------QVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKELKDS-EELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEEPS-CPLCHHNMTSD-EACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVEELLGDSVSEYETLIALIGEP----THNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDS-SVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLN-------SKYNSYKSTDHDIQR----LNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSK--NYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRNEECKSVIR 1304
BLAST of DNA repair protein RAD50 vs. Ensembl Fly
Match: rad50 (gene:FBgn0034728 transcript:FBtr0305323) HSP 1 Score: 452.595 bits (1163), Expect = 1.569e-136 Identity = 395/1357 (29.11%), Postives = 701/1357 (51.66%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNN--QFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETI-----SISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEK-GAVDSK-ISEKNNKQHEFDVN------IERFAGEINLSYDKDEADLA------IRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKI-TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRS-------EKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQ--------SKLSGFEFDLKQ---MKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKK---EICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITER-------NSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSL----ISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRR-TYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIK 3975
MS +ES++IQGIRSF + Q +KF PVTLILG NG GKTT++E L YA TG+ P GS G SFVHDPK+ G +EV A++ + ++D +G V+I R +K ++K +NK +S +T+DS+I G++ S+S + DI+V +++ +GVSKA++ NV+FCHQEDS+WPL E+K++KE+FD +F Y KALD I K++ + +K + +K++ + K + QR+ + + + S + +++PI+A + + RN ++ + + Q+ + + + QI L I P + EL++ IS+ D +L + Q + E +++ + K + QEK G D K K Q E ++ F E+++ D D + +R+IE I K ++V EK + + KI E+ +++S+ +EK ++ ++ E +G K+ ++ DL +L++++ EV + S + Q + +I + I ++ I K + LV + S +KN + R+RSR +D LF I Y + M + ++KL R +Q KL +++K+ + D + ++L D +E +Y+ C + + L+ + SKL+ + L+SS +LY K+ + + S CPLCH D E DL E+ ++ K P + R L +L +L ++++LK+ + E ++ + + + + IA + + ++N +A+S++GD++ +++ + + K++ + + QL S + + + + ++K + EL+ + +LE + + + N+L + N + +++++ LQ L+ + E L +T++ +++ + K+ P+ L+ I E+ + KL LN SK + Y++ I+R LNK + L N K+ + ++ L+ + SL + + + +N + R+ KD +++ +K K+ ES +L+ QL +D ++ + L K+R + + L + I++Q+ + +++++ R K++ N+ + Y+++V+ L I DL +Y AL+ A++ +H KM IN++++E WR Y G DIDYI++ +DE SS AS RR TYNYRVV K N + ++MRGRCSAGQ+VLA L+IRLALAE F +CGVLALDEPTTNLD NI SL +L I+ R Q+NF LI+ITHDE FV+ L + + +Y+R+F + S I+
Sbjct: 1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGKSFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKK-RNK-MSFETMDSTINFLTGAGQSKREKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKALDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKNCKDQISTLTLKIKKPFRGTLDELDQEISNFDQRMLEMRQKRTEVEGDLSQI--------KRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIIT--------KHCEITEIVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSM-----------QVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKELKDS-EELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEEPS-CPLCHHNMTSD-EACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVEELLGDSVSEYETLIALIGEP----THNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDS-SVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLN-------SKYNSYKSTDHDIQR----LNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLATEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSK--NYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRNEECKSVIR 1304
BLAST of DNA repair protein RAD50 vs. Ensembl Zebrafish
Match: rad50 (RAD50 homolog, double strand break repair protein [Source:ZFIN;Acc:ZDB-GENE-050506-110]) HSP 1 Score: 573.163 bits (1476), Expect = 0.000e+0 Identity = 404/1336 (30.24%), Postives = 726/1336 (54.34%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITK----ISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLD------NQLVIAEEKLESQKS--------SKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQS---KLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHSAN 3999
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y T+GD P GSK G +FVHDPK A E++V+A++ L +DV GD V + R+++ TQK K +TL+ I + + +GE +S+SSKCA+I+ EM +SLGVS+AVL +VIFCHQE+SNWPL+E K +K++FD +F++ RY+K L+ +R ++ + N++K+ + ELKYL+ + K E EL E + ++ ++ +++P++ + + K+ + + + K+ +E R+LE+ + S +L+ + + + E+ + + + + +E + LL E+G + + + D ++ A + L YD+ L+ R ++ + YR K+ LD NQ + ++ E+QK K E I + K +K++ L N+ L+ + +S +L + +L + +++L+ + + L++ L+ D + ++D + + + +K +++++SR N+ L++L + + L+ + K E K+ + K+++ L S K S + ++K+ K +QL K++E ++ +CG+ D + L + D+ K ++ L + ++YS+F + ++ CP+C R F ++E+ D+I+++ K P +L ++L + ++ + L + +L+E+ + +L + Q ++I L+ I + + E A + L D++ M+++ ++K +++ K+ + L + ++V+ +K+ ++ L +K+E +RK+ +D + L +N I E L I ++Q+ L+ Q EI +L +R ++++ +P+ L+++ E+ + + + KI+ + K++ I E+ K E + E ++ ++ ++ K + + + + I+ KV+ R +D L +R E++ ++ L ++ + +L + ++ +E+E++ +K+ R+ +I K+LN+ + AE Y + + ++ +ELA DLD YYKALD+ IM +H +KM EINKI+++LWR+TY G+DI+Y+EI SD +E++ A KRRTYNYRVVMVK A LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+++YRI + S+I C I+S N
Sbjct: 1 MSKIEKMSILGVRSFGVEDKDKQVISFFSPLTVLVGPNGAGKTTIIECLKYITSGDFPPGSK-GNTFVHDPKDAHETDVRAQIRLQFRDVNGDAVAVQRSMQCTQK--GKKTEFKTLEGVITR-IKHGEKVSLSSKCAEIDREMISSLGVSRAVLNHVIFCHQEESNWPLSEGKALKQKFDEIFSATRYIKVLETLRTLRQKQTNTVKSCQMELKYLKQ----NKDKAQEIRELLSTKETQLASSKESVNRIEGQIDPLERRLNDIESSLGKVMKLDNDIKALDSRKKQMEDDNRELEEKMEQVFQGSDDQLQDMYQNHQRTVKEKEKRLVECQRELERAGRECQRMNRIKSELLVEQGRLQLEADRHTQNIKKRDTQVKTLASFLELEGYDR--TPLSERQLQSF-------YRQIKERLDQDSEALNQTMHDMQQKETQKQHNIDDLRDKKTGLERTIELKKDLQAKKQQELKNIKSDLQKLEGSSNRLQELDTELQKAERELDNAVQACTVDSLKVEVTELLKEKAQLDQAQRKLDQEMEMLNTHTTARAQMDMMKKTKMDKEEQVRKIKSRHNEELVSLLGHFPNKKELEDWIYSKSREIKSTREQITKMNKELASGEQKKSHYTAEIKR------KEEQLA-KYEERLFNVCGSQDFQSDLSKLEDELEKCSKQRAMLAGATAVYSQFISQLTEEGDPCCPVCQRVFPSEAELQDVINDMQSKLRLVPDKLKNTEHDLKRKERRRDEMMTLKPIRQSLVELQEKELPELRNQLQRVNRDIEKLKGDIEEQETLLCTLVSEEETAKACLQDISLMDRFQLDLKDVER--KIAQHAAKLQGVDLSRTMQQVSQEKQETQHRLDTTSSKIELKRKLIQDQQEQIQALRSSVNEIRGEKLQISSNMQKRQQLEEQCVEFSTEIQTLHRDIRDAKEQASPLAATLEKLQQEKQDLVERRRKKQEEGQEKINAIKEKMKNITLFEKEITKYIEEGKDSYKEQKETELQEMDKQLHEAEKQREKTNKDMGNIRQDIDTQKVQERWLQDNLTLRKRVEELKEVSRKREALIKEMGNMQVLQLRNERREVERKLEDLKKNRSVALGRQKGYEDEILRFRKELNEDQYCRAEDLYRDKMIVMRTTELANKDLDIYYKALDQTIMRFHSMKMEEINKIIRDLWRSTYRGQDIEYVEIRSDVDENASAGVKRRTYNYRVVMVK--GDAALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLLVITHDEDFVELLGRSNYVEHFYRIRKNQDQCSEISKCSINSLN 1308
BLAST of DNA repair protein RAD50 vs. Ensembl Xenopus
Match: ENSXETT00000029229.1 (toll-like receptor13 [Source:Xenbase;Acc:XB-GENE-5873547]) HSP 1 Score: 606.675 bits (1563), Expect = 0.000e+0 Identity = 415/1324 (31.34%), Postives = 739/1324 (55.82%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITK--ISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEK-KVLDNQLV--------IAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDML-KKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++IQG+RSF + KN Q ++F P+TL++G NG GKTTIIE L Y TTGD P GSK G +FVHDPKVA E++V+A++ L +KDV G+ V + R++ TQK K +TL+ I + M +GE +S+S+KCA+++ EM ++LGVS AVL NVIFCHQEDSNWPL+E +Q+K +FD +F++ RY+KAL+ +RK++L++ +++ Y+ E+KYL+ N + + N ++ ++ ++K + S++++LEP+ + + TK+ + + + K +E +DLE+ + + EL + + + E+ + + +++ KE+ +E LL ++G + + + D I+ A ++ L +++ R ++ + +K R EK + NQ++ + + +++ + K E I + + ++K L N+ +L+ + +S +L + +L + +++LE V+ + N + R + +L DL+ + D + + ++D L + +++K+ +++++SR ND L +L + L+ L K K+ + +KL R + +L E + + + + ++ F+E V+++CG+ D + L +D K ++ L + ++Y++F L ++N+ CP+C R F ++E+ D+I+++ K P +L EL + ++ + +L + DLKE+ + ++ K +EI L+ + + + E A + L D++ ME+Y E++ +++ K+ + L + ++V +K+ ++ L ++ K+E RK +D + +L +N +T+E L+I +LQ L+ Q L E+ L +++ +++++ P+ L++ E+ L A+ K++ + K++ I ++ K + + E ++ L +++ K + + + I+ K++ R +D L +R E++ ++EE L ++ + ++ + ++ +ELE + +K R+ +I K+L + + KDAE Y + + ++ +ELAI DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E A+ KRRTYNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+++YRI + S+I C ++S
Sbjct: 1 MSKIEKMSIQGVRSFGIEDKNKQVIQFFTPLTLLVGPNGAGKTTIIECLKYITTGDFPPGSK-GKTFVHDPKVAHETDVRAQIRLQLKDVNGELVAVQRSMICTQK--GKSTEFKTLEGVITR-MKHGEKVSLSTKCAEMDKEMISALGVSSAVLNNVIFCHQEDSNWPLSEGRQLKVKFDEIFSATRYIKALETLRKVRLNQAQNVREYQVEIKYLKQ--NKEKAREIQDNLQSKEKQLAVSKENVKSIESQLEPLKDRLADIQRNLTKVMRLDNEIKALESRKRTMEKDNQDLEEKMEKVFQGTDEELSDMYQNHQRTVREKERKLNDHQRDMDRACKESQRLNREKGELLVQQGRLQLEADQHQQYIKTRDSLIKSLAAQLELDGFER--TPFNQRQTSNF--QMLVKERQEKDEAHANQILREFSEREAMKQRQIDEIRDKKTGLERTIELKSSTQSKKHTDLKNVKYELQQLEGSSDRLQELDEELQKTERELENVEKSCNLEALRGEVAQLQSQKSDLDRNVRKLDQEMEQLNTHTMTRTQMDMLKKDKADKDEQIRKIKSRHNDELSSLIGYFPNKKQLEDWLYSKR---KDVNQTREKLARFTK-ELVAAEQNKNHLSNELRRKEEQSTSFEEKVFDVCGSQDFDSDLSRLQDDIEKTSKQRAMLAGATAVYTQFITTLTEENQPCCPVCQRIFPSEAELQDVINDMQSKLRLVPDKLKAAEGELKRKEKRKDEMMELKPMRQMLADLKEKEVPEIRNKLVAINREIQRLKNDVEEQETLIATFVSEEESAKACLQDISLMERYQMELRDVER--KIAQYATKLQGVDLNRTVQQVNQEKQEKQHSLDNVSGKIELLRKRIQDQQEQVQQLKSTVNELTAEKLHISSNLQRRQQLEEQNVELTTELQCLSREIKEAKEQVFPLESTLQKFQQEKQELLQRKELSYREAQEKVNDIKEKVKKINLFSKDIEKYIQDGKEDFKEQKECELQELIARLNECEKQKEKINREMVNIRQDIDTQKIQERCLQDNLTLRKRIEELKRVEEERQQLLKEMGQMKVMQMKNEHQELENKSETLKTNHSLALGRQKGFEDEILRFKKELREPQYKDAEEKYRDKMIVMRTTELAIKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADEGVSAADKRRTYNYRVVMIK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLVVITHDEDFVELLGRSEYVEHFYRIKKNIDQCSEIMRCSVNS 1306
BLAST of DNA repair protein RAD50 vs. Ensembl Xenopus
Match: ENSXETT00000013112.1 (toll-like receptor13 [Source:Xenbase;Acc:XB-GENE-5873547]) HSP 1 Score: 560.451 bits (1443), Expect = 1.010e-176 Identity = 391/1276 (30.64%), Postives = 704/1276 (55.17%), Query Frame = 1
Query: 193 TIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITK--ISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEK----KVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDML-KKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
TIIE L Y TTGD P GSK G +FVHDPKVA E++V+A++ L +KDV G+ V + R++ TQK K +TL+ I + M +GE +S+S+KCA+++ EM ++LGVS AVL NVIFCHQEDSNWPL+E +Q+K +FD +F++ RY+KAL+ +RK++L++ +++ Y+ E+KYL+ N + + N ++ ++ ++K + S++++LEP+ + + TK+ + + + K +E +DLE+ + + EL + + + E+ + + +++ KE+ +E LL ++G + + + D I+ A ++ L +++ R ++ + +K R EK + + + + +++ + K E I + + ++K L N+ +L+ + +S +L + +L + +++LE V+ + N + R + +L DL+ + D + + ++D L + +++K+ +++++SR ND L +L + L+ L K K+ + +KL R + +L E + + + + ++ F+E V+++CG+ D + L +D K ++ L + ++Y++F L ++N+ CP+C R F ++E+ D+I+++ K P +L EL + ++ + +L + DLKE+ + ++ K +EI L+ + + + E A + L D++ ME+Y E++ +++ K+ + L + ++V +K+ ++ L ++ K+E RK +D + +L +N +T+E L+I +LQ L+ Q L E+ L +++ +++++ P+ L++ E+ L A+ K++ + K++ I ++ K + + E ++ L +++ K + + + I+ K++ R +D L +R E++ ++EE L ++ + ++ + ++ +ELE + +K R+ +I K+L + + KDAE Y + + ++ +ELAI DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E A+ KRRTYNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+++YRI + S+I C ++S
Sbjct: 4 TIIECLKYITTGDFPPGSK-GKTFVHDPKVAHETDVRAQIRLQLKDVNGELVAVQRSMICTQK--GKSTEFKTLEGVITR-MKHGEKVSLSTKCAEMDKEMISALGVSSAVLNNVIFCHQEDSNWPLSEGRQLKVKFDEIFSATRYIKALETLRKVRLNQAQNVREYQVEIKYLKQ--NKEKAREIQDNLQSKEKQLAVSKENVKSIESQLEPLKDRLADIQRNLTKVMRLDNEIKALESRKRTMEKDNQDLEEKMEKVFQGTDEELSDMYQNHQRTVREKERKLNDHQRDMDRACKESQRLNREKGELLVQQGRLQLEADQHQQYIKTRDSLIKSLAAQLELDGFER--TPFNQRQTSNF--QMLVKERQEKDEAHREFSEREAMKQRQIDEIRDKKTGLERTIELKSSTQSKKHTDLKNVKYELQQLEGSSDRLQELDEELQKTERELENVEKSCNLEALRGEVAQLQSQKSDLDRNVRKLDQEMEQLNTHTMTRTQMDMLKKDKADKDEQIRKIKSRHNDELSSLIGYFPNKKQLEDWLYSKR---KDVNQTREKLARFTK-ELVAAEQNKNHLSNELRRKEEQSTSFEEKVFDVCGSQDFDSDLSRLQDDIEKTSKQRAMLAGATAVYTQFITTLTEENQPCCPVCQRIFPSEAELQDVINDMQSKLRLVPDKLKAAEGELKRKEKRKDEMMELKPMRQMLADLKEKEVPEIRNKLVAINREIQRLKNDVEEQETLIATFVSEEESAKACLQDISLMERYQMELRDVER--KIAQYATKLQGVDLNRTVQQVNQEKQEKQHSLDNVSGKIELLRKRIQDQQEQVQQLKSTVNELTAEKLHISSNLQRRQQLEEQNVELTTELQCLSREIKEAKEQVFPLESTLQKFQQEKQELLQRKELSYREAQEKVNDIKEKVKKINLFSKDIEKYIQDGKEDFKEQKECELQELIARLNECEKQKEKINREMVNIRQDIDTQKIQERCLQDNLTLRKRIEELKRVEEERQQLLKEMGQMKVMQMKNEHQELENKSETLKTNHSLALGRQKGFEDEILRFKKELREPQYKDAEEKYRDKMIVMRTTELAIKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADEGVSAADKRRTYNYRVVMIK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLVVITHDEDFVELLGRSEYVEHFYRIKKNIDQCSEIMRCSVNS 1261
BLAST of DNA repair protein RAD50 vs. Ensembl Xenopus
Match: ENSXETT00000013125.1 (toll-like receptor13 [Source:Xenbase;Acc:XB-GENE-5873547]) HSP 1 Score: 546.969 bits (1408), Expect = 1.326e-171 Identity = 392/1319 (29.72%), Postives = 714/1319 (54.13%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITK--ISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEK----KVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDML-KKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++IQG+RSF + KN Q ++F P+TL++G NG GKT VA E++V+A++ L +KDV G+ V + R++ TQ K K +TL+ I + M +GE +S+S+KCA+++ EM ++LGVS AVL NVIFCHQEDSNWPL+E +Q+K +FD +F++ RY+KAL+ +RK++L++ +++ Y+ E+KYL+ N + + N ++ ++ ++K + S++++LEP+ + + TK+ + + + K +E +DLE+ + + EL + + + E+ + + +++ KE+ +E LL ++G + + + D I+ A ++ L +++ R ++ + +K R EK + + + + +++ + K E I + + ++K L N+ +L+ + +S +L + +L + +++LE V+ + N + R + +L DL+ + D + + ++D L + +++K+ +++++SR ND L +L + L+ L K K+ + +KL R + +L E + + + + ++ F+E V+++CG+ D + L +D K ++ L + ++Y++F L ++N+ CP+C R F ++E+ D+I+++ K P +L EL + ++ + +L + DLKE+ + ++ K +EI L+ + + + E A + L D++ ME+Y E++ +++ K+ + L + ++V +K+ ++ L ++ K+E RK +D + +L +N +T+E L+I +LQ L+ Q L E+ L +++ +++++ P+ L++ E+ L A+ K++ + K++ I ++ K + + E ++ L +++ K + + + I+ K++ R +D L +R E++ ++EE L ++ + ++ + ++ +ELE + +K R+ +I K+L + + KDAE Y + + ++ +ELAI DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E A+ KRRTYNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+++YRI + S+I C ++S
Sbjct: 1 MSKIEKMSIQGVRSFGIEDKNKQVIQFFTPLTLLVGPNGAGKT-----------------------------VAHETDVRAQIRLQLKDVNGELVAVQRSMICTQ--KGKSTEFKTLEGVITR-MKHGEKVSLSTKCAEMDKEMISALGVSSAVLNNVIFCHQEDSNWPLSEGRQLKVKFDEIFSATRYIKALETLRKVRLNQAQNVREYQVEIKYLKQ--NKEKAREIQDNLQSKEKQLAVSKENVKSIESQLEPLKDRLADIQRNLTKVMRLDNEIKALESRKRTMEKDNQDLEEKMEKVFQGTDEELSDMYQNHQRTVREKERKLNDHQRDMDRACKESQRLNREKGELLVQQGRLQLEADQHQQYIKTRDSLIKSLAAQLELDGFER--TPFNQRQTSNF--QMLVKERQEKDEAHREFSEREAMKQRQIDEIRDKKTGLERTIELKSSTQSKKHTDLKNVKYELQQLEGSSDRLQELDEELQKTERELENVEKSCNLEALRGEVAQLQSQKSDLDRNVRKLDQEMEQLNTHTMTRTQMDMLKKDKADKDEQIRKIKSRHNDELSSLIGYFPNKKQLEDWLYSKR---KDVNQTREKLARFTK-ELVAAEQNKNHLSNELRRKEEQSTSFEEKVFDVCGSQDFDSDLSRLQDDIEKTSKQRAMLAGATAVYTQFITTLTEENQPCCPVCQRIFPSEAELQDVINDMQSKLRLVPDKLKAAEGELKRKEKRKDEMMELKPMRQMLADLKEKEVPEIRNKLVAINREIQRLKNDVEEQETLIATFVSEEESAKACLQDISLMERYQMELRDVER--KIAQYATKLQGVDLNRTVQQVNQEKQEKQHSLDNVSGKIELLRKRIQDQQEQVQQLKSTVNELTAEKLHISSNLQRRQQLEEQNVELTTELQCLSREIKEAKEQVFPLESTLQKFQQEKQELLQRKELSYREAQEKVNDIKEKVKKINLFSKDIEKYIQDGKEDFKEQKECELQELIARLNECEKQKEKINREMVNIRQDIDTQKIQERCLQDNLTLRKRIEELKRVEEERQQLLKEMGQMKVMQMKNEHQELENKSETLKTNHSLALGRQKGFEDEILRFKKELREPQYKDAEEKYRDKMIVMRTTELAIKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADEGVSAADKRRTYNYRVVMIK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLVVITHDEDFVELLGRSEYVEHFYRIKKNIDQCSEIMRCSVNS 1273
BLAST of DNA repair protein RAD50 vs. Ensembl Xenopus
Match: ENSXETT00000013101.1 (toll-like receptor13 [Source:Xenbase;Acc:XB-GENE-5873547]) HSP 1 Score: 317.775 bits (813), Expect = 2.728e-94 Identity = 205/577 (35.53%), Postives = 334/577 (57.89%), Query Frame = 1
Query: 2266 TQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
Q + DLKE+ + ++ K +EI L+ + + + E A + L D++ ME+Y E++ +++ K+ + L + ++V +K+ ++ L ++ K+E RK +D + +L +N +T+E L+I +LQ L+ Q L E+ L +++ +++++ P+ L++ E+ L A+ K++ + K++ I ++ K + + E ++ L +++ K + + + I+ K++ R +D L +R E++ ++EE L ++ + ++ + ++ +ELE + +K R+ +I K+L + + KDAE Y + + ++ +ELAI DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E A+ KRRTYNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+++YRI + S+I C ++S
Sbjct: 17 VQKQMLADLKEKEVPEIRNKLVAINREIQRLKNDVEEQETLIATFVSEEESAKACLQDISLMERYQMELRDVER--KIAQYATKLQGVDLNRTVQQVNQEKQEKQHSLDNVSGKIELLRKRIQDQQEQVQQLKSTVNELTAEKLHISSNLQRRQQLEEQNVELTTELQCLSREIKEAKEQVFPLESTLQKFQQEKQELLQRKELSYREAQEKVNDIKEKVKKINLFSKDIEKYIQDGKEDFKEQKECELQELIARLNECEKQKEKINREMVNIRQDIDTQKIQERCLQDNLTLRKRIEELKRVEEERQQLLKEMGQMKVMQMKNEHQELENKSETLKTNHSLALGRQKGFEDEILRFKKELREPQYKDAEEKYRDKMIVMRTTELAIKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADEGVSAADKRRTYNYRVVMIK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLVVITHDEDFVELLGRSEYVEHFYRIKKNIDQCSEIMRCSVNS 589
BLAST of DNA repair protein RAD50 vs. Ensembl Mouse
Match: Rad50 (RAD50 double strand break repair protein [Source:MGI Symbol;Acc:MGI:109292]) HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0 Identity = 417/1337 (31.19%), Postives = 738/1337 (55.20%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKV---------LDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ V + R++ +QK NK +TL+ I + M +GE +S+SSKCA+I+ EM + LGVSK+VL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KALD +R+++ + +K +TELKYL + A + S+ +L E+ + S + +LEP+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + + L+KE +E LL E+G + + D I+ A + L +++ + R I+++ + +K R E++ L ++ + + +L+ + K I + L +K+ L ++ +L+ + +S ++ EL Q+L + + + E +++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + K ++ + +++ ++++CG+ DL + L +++ K ++ L + ++YS+F + +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L + Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ ++ L + +K+E RK+ +D + L + N + SE L I +LQ ++ Q L E+ SL +++ ++++++P+ L+++ E+ + + A+ KI+ + K++ I ++ + ++ + ++ + ++ K + + + I+ K++ R +D L +R +++ ++EE ++ + +L + ++ ++LE+ IK R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YR+ + S+I C I S
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQK--NKKTEFKTLEGVITR-MKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEI----VRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALESRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNKEARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFER--GPFSERQIKNF--HELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEILTKKQSELRHVRSELQQLEGSSDRI-------LELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDELKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISS 1306
BLAST of DNA repair protein RAD50 vs. Ensembl Mouse
Match: Rad50 (RAD50 double strand break repair protein [Source:MGI Symbol;Acc:MGI:109292]) HSP 1 Score: 241.121 bits (614), Expect = 4.617e-68 Identity = 109/218 (50.00%), Postives = 159/218 (72.94%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQ 717
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ V + R++ +QK NK +TL+ I + M +GE +S+SSKCA+I+ EM + LGVSK+VL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KALD +R+++ + +K +TELKYL+
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQK--NKKTEFKTLEGVITR-MKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLK 214
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Match: sp|P70388|RAD50_MOUSE (DNA repair protein RAD50 OS=Mus musculus OX=10090 GN=Rad50 PE=1 SV=1) HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0 Identity = 417/1337 (31.19%), Postives = 738/1337 (55.20%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKV---------LDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ V + R++ +QK NK +TL+ I + M +GE +S+SSKCA+I+ EM + LGVSK+VL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KALD +R+++ + +K +TELKYL + A + S+ +L E+ + S + +LEP+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + + L+KE +E LL E+G + + D I+ A + L +++ + R I+++ + +K R E++ L ++ + + +L+ + K I + L +K+ L ++ +L+ + +S ++ EL Q+L + + + E +++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + K ++ + +++ ++++CG+ DL + L +++ K ++ L + ++YS+F + +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L + Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ ++ L + +K+E RK+ +D + L + N + SE L I +LQ ++ Q L E+ SL +++ ++++++P+ L+++ E+ + + A+ KI+ + K++ I ++ + ++ + ++ + ++ K + + + I+ K++ R +D L +R +++ ++EE ++ + +L + ++ ++LE+ IK R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YR+ + S+I C I S
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVAVHRSMLCSQK--NKKTEFKTLEGVITR-MKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLKQNKEKACEIRDQITSKEAQLASSQEI----VRSYEDELEPLKNRLKEIEHNLSKIMKLDNEIKALESRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLNKEARLLNQEKAELLVEQGRLQLQADRHQEHIRARDSLIQSLATHLELDGFER--GPFSERQIKNF--HELVKERQEREAKTASQLLSDLTDKEALKQRQLDELRDRKSGLGRTIELKTEILTKKQSELRHVRSELQQLEGSSDRI-------LELDQELTKAERELSKAEKNSSIETLKAEVMSLQNEKADLDRSLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDLESDLGRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPVRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGVDLDRTVQQVNQEKQEKQHRLDTVTSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQSVELSTEVQSLNREIKDAKEQISPLETALEKLQQEKEELIHRKHTSNKMAQDKINDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNGVAVQLNECEKHREKINKDMGTMRQDIDTQKIQERWLQDNLTLRKRRDELKEVEEEPKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEDEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRVKKNMDQCSEIVKCSISS 1306
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Match: sp|Q92878|RAD50_HUMAN (DNA repair protein RAD50 OS=Homo sapiens OX=9606 GN=RAD50 PE=1 SV=1) HSP 1 Score: 578.17 bits (1489), Expect = 0.000e+0 Identity = 434/1351 (32.12%), Postives = 742/1351 (54.92%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQ----KEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLK-KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINS--NNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVI-------------------KRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ + + R++ TQK +K +TL+ I + +GE +S+SSKCA+I+ EM +SLGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KAL+ +R+++ + +K Y+ ELKYL + A + S+ +L E+ + S + +L+P+ +++ + +K+ + + + + K+ +E +LE+ + + +L L + + E+ + + L+KE+ +E LL E+G + + D I+ A ++ L +++ + R I+++ + + E K NQL+ + E+ K +I +EI K L + K + L +L+ + Y +L ++ + EL Q+L + + + E N++ L + L+N+ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + + ++ + +++ ++++CG+ D + L +++ K ++ L + ++YS+F L +N+S CP+C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L K Q ++I L+ I + Q+ + + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L N + SE L I +LQ L+ Q L E+ SL +++ ++++++P+ L++ E+ + N A+ K++ + K++ I K+ TELNK I L S+ + + + I++ L+ Q I+ K++ R +D L +R E++ ++EE ++ + +L + S+ ++LE+ IK + R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD+AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG++ALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YRI + S+I C + S
Sbjct: 1 MSRIEKMSILGVRSFGIEDKDKQIITFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGELIAVQRSMVCTQK--SKKTEFKTLEGVITRT-KHGEKVSLSSKCAEIDREMISSLGVSKAVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALETLRQVRQTQGQKVKEYQMELKYLKQYKEKACEIRDQITSKEAQLTSSKEI----VKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKALDSRKKQMEKDNSELEEKMEKVFQGTDEQLNDLYHNHQRTVREKERKLVDCHRELEKLNKESRLLNQEKSELLVEQGRLQLQADRHQEHIRARDSLIQSLATQLELDGFER--GPFSERQIKNFHKLVRERQEGEAKTA-NQLMNDFAEKETLKQKQI---DEIRDKKTGLGRIIELKSEILSKKQNELKNVKYELQQLEGSSDRILELDQELIKAERELSKAEKNSNVETLKMEVISLQNEKADLDRTLRKLDQEMEQLNHHTTTRTQMEMLTKDKADKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASSEQNKNHINNELKRKEEQLSSYEDKLFDVCGSQDFESDLDRLKEEIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLVPMRQSIIDLKEKEIPELRNKLQNVNRDIQRLKNDIEE--QETLLGTIMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGIDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSTTNELKSEKLQISTNLQRRQQLEEQTVELSTEVQSLYREIKDAKEQVSPLETTLEKFQQEKEELINKKNTSNKIAQDKLNDIKEKVKNIHGYMKDIENYIQDGKDDYKKQKETELNKV---------------IAQL-SECEKHKEKINEDMRLMRQ---DIDTQKIQERWLQDNLTLRKRNEELKEVEEERKQHLKEMGQMQVLQMKSEHQKLEENIDNIKRNHNLALGRQKGYEEEIIHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDQAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGIIALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRIKKNIDQCSEIVKCSVSS 1306
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Match: sp|Q9JIL8|RAD50_RAT (DNA repair protein RAD50 OS=Rattus norvegicus OX=10116 GN=Rad50 PE=1 SV=1) HSP 1 Score: 557.755 bits (1436), Expect = 1.366e-174 Identity = 414/1320 (31.36%), Postives = 720/1320 (54.55%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYL----QTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKV-------LDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYN-------EIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRI--LQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLK-KNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQ----LNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRI 3942
MS +E ++ G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y TGD P G+K G +FVHDPKVA E++V+A++ L +DV G+ V + R++ +QK +K +TL+ I + + +GE +S+SSKCA+I+ EM + LGVSK+VL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KALD +R+++ + +K +TELKYL + A + S+ +L E+ + + + +LEP+ +++ + +K+ + + + K+ +E +LE+ + + +L L + + E+ + + + L KE +E LL E+G + + D I+ A + L +++ + R I+++ + + E K L ++ + + +++ + K I + L +K+ L N+ +L+ + +S ++ EL Q+L + + + E +++ L I +L+++ D D + K + ++ N +++ L + +++K+ +++++SR +D L +L P KK L+ L K+K I Q DR+ L +L+ E + + + K ++ + +++ ++++CG+ D + L ++ K ++ L + ++YS+F L +N+S CP C R FQ ++E+ ++I ++ K AP +L +EL + ++ + L I DLKE+ I +L + Q ++I L+ I + E A L DV ME++ E+K +++ K+ +Q L + ++V +K+ +++L + +K+E RK+ +D + L + N + SE L I +LQ ++ Q L E+ SL +++ +++++ P+ L+++ E+ + N A+ KI+ + K++ I + ++ + + K LN ++ L D K I++ + I+ K++ R +D L +R E++ ++EE ++ + +L + ++ ++LE+ IK R+ +I + K+L + + +DAE Y EM+ ++ +EL DLD YYK LD AIM +H +KM EINKI+++LWR+TY G+DI+YIEI SD +E+ AS KRR YNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL+VITHDE+FV LL RS+YV+ +YR+
Sbjct: 1 MSRIEKMSTLGVRSFGIEDKDKQIISFFSPLTILVGPNGAGKTTIIECLKYICTGDFPPGTK-GNTFVHDPKVAQETDVRAQIRLQFRDVNGEMVLVQRSMLCSQK--SKKTEFKTLEGVITR-IKHGEKVSLSSKCAEIDREMISCLGVSKSVLNNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDTLRQVRQTQGQKVKECQTELKYLRQNKEKACEIRDQITSKEAQLASSREI----VKAYENELEPLKNRLKEIEHNLSKIMRLDNEIKALDSRKKQMEKDNSELEQKMEKVFQGTDEQLNDLYHNHQRTVREKERRLVDCQRELEKLSKEARLLNQERAELLVEQGRLQLQADRHQEHIRARDSLIQSLAAHLELDGFER--GPFSERQIKNFHELVRERQEREAKTASQLLSDLTDKEALKQRQMDEMRDKKSGLGRMIELKTEILTKKQTELRNVRNELQQLEGSSDRI-------LELDQELTKAERELSKAEKNSSIETLKAEILNLQSEKADLDRNLRKLDQEMEQLNHHTTTRTQMEMLTKDKTDKDEQIRKIKSRHSDELTSLL-GYFPN---KKQLED-WLHSKSKEIN-QTRDRLAKLNKELASAEQNKNHINNELKKKEEQLSSYEDKLFDVCGSQDFESDLDRLKEDIEKSSKQRAMLAGATAVYSQFITQLTDENQSCCPGCQRVFQTEAELQEVISDLQSKLRLAPDKLKSTESELKKKERRRDEMLGLVPMRQSIIDLKEKEIPELRNRLQSVNRDIQRLKNDIEEQETLLGTVMPEEESAKVCLTDVTIMERFQMELKDVER--KIAQQAAKLQGVDLDRTVQQVNQEKQEKQHKLDTVSSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIATNLQRRQQMEEQTVELSTEVQSLNREIKDAKEQINPLEIALEKLQQEKEELIHRKNTSNKMAQDKINDIKEKVKNI---HGYMKDIENYIQDGKDDYKKQKETELN-EVVIQLNECDKHKEKINKEMGTMRQDIDTKKIQERWLQDNLTLRKRREELKEVEEERKQHLKEMGQMQVLQMKNEHQKLEENIDTIKRNHSLALGRQKGYEEEILHFKKELREPQFRDAEEKYREMMIVMRTTELVNKDLDIYYKTLDHAIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYIEIRSDADENVSASDKRRNYNYRVVMLK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSQQRNFQLLVITHDEDFVELLGRSEYVEKFYRV 1289
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Match: sp|Q9W252|RAD50_DROME (DNA repair protein RAD50 OS=Drosophila melanogaster OX=7227 GN=rad50 PE=2 SV=4) HSP 1 Score: 453.751 bits (1166), Expect = 5.076e-136 Identity = 397/1358 (29.23%), Postives = 703/1358 (51.77%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNN--QFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETI-----SISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQR-EISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEK-GAVDSK-ISEKNNKQHEFDVN------IERFAGEINLSYDKDEADLA------IRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKI-TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRS-------EKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQ--------SKLSGFEFDLKQ---MKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKK---EICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITER-------NSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSL----ISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRR-TYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIK 3975
MS +ES++IQGIRSF + Q +KF PVTLILG NG GKTT++E L YA TG+ P GS G SFVHDPK+ G +EV A++ + ++D +G V+I R +K ++K +NK +S +T+DS+I G++ S+S + DI+V +++ +GVSKA++ NV+FCHQEDS+WPL E+K++KE+FD +F Y KALD I K++ + +K + +K++ + K + QR+ + + + S + +++PI+A + + RN ++ + + Q+ E+ K + QI L I P + EL++ IS+ D +L + Q + E +++ + K + QEK G D K K Q E ++ F E+++ D D + +R+IE I K ++V EK + + KI E+ +++S+ +EK ++ ++ E +G K+ ++ DL +L++++ EV + S + Q + +I + I ++ I K + LV + S +KN + R+RSR +D LF I Y + M + ++KL R +Q KL +++K+ + D + ++L D +E +Y+ C + + L+ + SKL+ + L+SS +LY K+ + + S CPLCH D E DL E+ ++ K P + R L +L +L ++++LK+ + E ++ + + + + IA + + ++N +A+S++GD++ +++ + + K++ + + QL S + + + + ++K + EL+ + +LE + + + N+L + N + +++++ LQ L+ + E L +T++ +++ + K+ P+ L+ I E+ + KL LN SK + Y++ I+R LNK + L N K+ + ++ L+ ++ SL + + + +N + R+ KD +++ +K K+ ES +L+ QL +D ++ + L K+R + + L + I++Q+ + +++++ R K++ N+ + Y+++V+ L I DL +Y AL+ A++ +H KM IN++++E WR Y G DIDYI++ +DE SS AS RR TYNYRVV K N + ++MRGRCSAGQ+VLA L+IRLALAE F +CGVLALDEPTTNLD NI SL +L I+ R Q+NF LI+ITHDE FV+ L + + +Y+R+F + S I+
Sbjct: 1 MSSIESLSIQGIRSFGTYADDLQSIKFSSPVTLILGENGCGKTTVVECLKYALTGECPPGSDRGKSFVHDPKIFGLNEVLAQIKMQVRDRRGAQVSICRTMKVSKK-RNK-MSFETMDSTINFLTGAGQSKREKQDSLSGRSVDIDVAISDFMGVSKAIINNVLFCHQEDSSWPLDESKKLKEKFDAIFGITEYNKALDKIIKLRKEAMEELKIKEANIKHVAYLKQEMEVKTLNLQKAQRKCDAIKAQCSECEEEMKPIEARLVEIRNVEFEIGKYQAQKVEMDTKHKN-CKDQISTLTLKIKKPFRGTLDELDQEISNFDQRMLEMRQKRTEVEGDLSQI--------KRSSVAEQEKLGTQDRKHCLAKQRHQSELACRAQLLKRVKEFCRELHIPIDCDLVEQPEKMGEVLRDIEAMIIT--------KHCEITEIVEQNEKADRSRQVKIDELRIELTKSEQSVTAQEKQRESSKRESETLGVEIKKIETSMQDLKKLEKEINEVNELYESATKNIDQQAIKDAIARKKASIAENQIQFKKLDEQLTFLGSMAKLVAECSLKQKELDKKNQEVHRVRSRHSDHFGKLFKEPITCNYRRSM-----------QVVYEKLRREIQELNEKANTQKLKEQSYEIKRKNLISDISRMEKELKDS-EELIYQKCRSTPYDDLLERSKTTISKLQFDHGALKSSEALYKKYIQKMDEEPS-CPLCHHNMTSD-EACDLTSELTDEIQKLPDNITRAEKALKAEQIKYENLLQLKPTILKVKELKDSLPQKKEELKKVEELLGDSVSEYETLIALIGEP----THNMELANSMMGDMSLLDEALKDSARLTKDLDLQKGQLPASYDS-SVSMDDLQAEKSKVSKELETERKELESAQNAVQQQMDALNRLREKKNSLKDRQIHLREGLQSLPQLKERLEKLNSFLTTVASEISELKAKIQPLKLNLRAAIEEKERLKKSESEKLAQLN-------SKYNSYKSTDHDIQR----LNKEAEDYAKLDLRNEIKKLDEIIMASKDKLRKLEAEISLKTDELETIKTECSNQQTVERDLKDNRELKQLEDKEAKLRESCQVLDKQLGNLDFHSVSKEKVNLTKQRDKATVRKGELLGQLGEIHSQVNKLQREIDEPRFKESLKNFRKANYEIEVTRLCIEDLGQYRLALEWALIQFHSEKMEMINRLIREYWRKIYRGNDIDYIQVKTDEVSSDASADRRKTYNYRVVQSK--NYSEIEMRGRCSAGQRVLASLIIRLALAETFSSNCGVLALDEPTTNLDRANINSLCEALNCIVEERQSQSNFMLIIITHDENFVSSLGK---ITSYHRVFRNEECKSVIR 1304
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Match: sp|Q54CS9|RAD50_DICDI (DNA repair protein RAD50 OS=Dictyostelium discoideum OX=44689 GN=rad50 PE=3 SV=1) HSP 1 Score: 248.825 bits (634), Expect = 1.190e-65 Identity = 135/302 (44.70%), Postives = 189/302 (62.58%), Query Frame = 1
Query: 3073 ISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGV--DLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQI 3972
IS + +++ + R D + R H + +I I N + + L IDS +LE+E +K + D + + + +QI ++L+ K+ + +++ KL+ +E DLDKYYKALDK++M YH +KM EIN+ +KE+W+ TY G DID IEI S+E + T +T NYRVVM+K LDMRGRCSAGQKVLACL+IRLALAE FC +CG+LALDEPT++LD NI S A+SL+ II +R Q FQLI+ITHDEEFV LSR +Y D Y+R+ + + HS +
Sbjct: 1050 ISTIQQNLSSKDITKRAISDNISFRQHKNNVEQIIRQISRKNELIKEMMQSQLEIDSN--KLEQEINSLKSKFDQITGQTAVLQSQINSNRQELSKPTYKNIDDVNKDLLIKLQTTETVGKDLDKYYKALDKSLMKYHTLKMDEINRSIKEIWQTTYKGSDIDTIEIRSEE----SGTANKTINYRVVMIK--GDVELDMRGRCSAGQKVLACLVIRLALAENFCSNCGILALDEPTSHLDRANIESFANSLLNIIESRKSQKGFQLIIITHDEEFVQYLSRGNYCDYYWRVTKNANQHSHL 1343 HSP 2 Score: 209.534 bits (532), Expect = 1.943e-53 Identity = 93/213 (43.66%), Postives = 145/213 (68.08%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELK 708
M+ +E + +QGIRSFDP+ + F P+TLI+G NG GKTTIIE L Y TG++P +G +F+HD K+AGESEVKA++ L K+ G + +R+L QK NK + +D+S+Q ++G+ +S S +C+D++ E+ + +GV+K +L++VIFCHQEDSNWPL+E+ ++K +FD +F++ +Y KAL +++ DK + T ELK
Sbjct: 1 MTSIEKLLVQGIRSFDPREASVIDFYSPLTLIVGQNGAGKTTIIECLKYTCTGEMPPNCSSGQAFIHDTKIAGESEVKAQIKLRFKNPIGKPIVASRSLSLIQKS-NKKQEYKQIDASLQSYTSDGQKVSKSFRCSDMDKEIPDLMGVAKPILKHVIFCHQEDSNWPLSESAKLKLKFDEIFSAVKYTKALKSLK----DKRKELTTLIKELK 208
BLAST of DNA repair protein RAD50 vs. TrEMBL
Match: A0A095CCX2 (DNA repair protein RAD50 (Fragment) OS=Schistosoma haematobium OX=6185 GN=MS3_08938 PE=4 SV=1) HSP 1 Score: 676.011 bits (1743), Expect = 0.000e+0 Identity = 516/1395 (36.99%), Postives = 778/1395 (55.77%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKL-SERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKE--MIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINLSYDKDEADLAIRNIED----YIANLT--LKYRDEKKVLDNQLVIAEEKLESQKSSKI------TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKE-------TRENLQRLMQSI-------RDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLF-DNMIPETYLKKMLDQK-----LLEFKNKHIEFQ-----KLDRILQS------KLSGFEFDLKQMK-DSAIKHQQLVDKFDE------DVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIEN---ELKDMKNKL--------EKERKI------YEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLN--NYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQ----LNFKINNHKVRMREYKDTLQIRH---HGEKIVKIEESIG-----ILNAQLAGVDLLNIDSKMKELEKER-RQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGA---STKRRTYNYRVVMVKRHNG------------------ARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYY 3936
M+++E ++I GIRSF + +Q ++F PVTLILG NGTGKTT+IE L Y+ TG+LP GSKTG SF+HDP++A ESEVKAKV+L I+DVKG + ++RAL TQ+DK K +++TLD SI++ ++G S+S +C D++ EM SLGVSKAVLENVIFCHQEDSNWPL EAK VK+RFD+LFAS+RYVKALD IRK K D + ++K YKTELK+L T D KL SER E E + + KL+P+ + +Y+ ++ +L TK Q EI E E + I++L NI S EL++LI D++ + + E+ + KE N + + + EK ++ ++ N E +N + I +Y + ++ D YI L + E ++ + +L+ A E+ ++Q + + +I KR+ NQ+ + ++ K+LE N LN +++E+V+ F+ E L L QSI ++LE+ I D I +Q KY E++ + ++R+ K ++++RSR + L +F ++IP +K L+++ + F N + +LD + QS +L+ E + ++ S L +K D+ + + G DL +L +D++ LEEE Q SV L+ KF+D L + SDCP+CHR F D+E D+L++EI+ + PSE R EL +I + SL +L S +I++L E +I LE K + ++ D++ + S E +E +A ++ GD+A +E+ +E +LT+ +FK EF +T+ + I+ E K ++ L EK++++ ++ +K ++L +++++ ENL+ + + S L E L +E++ L+++ +L V E ER S++ + N E A +KI+ KL+ + T + A E L+ I + L Q NL + SQ L +IN HK+R RE D +Q+R H + + ES+ N L+ DL+N ++K LE+E+ +K+ I + + + +N ++ Y+ +DLN+ + +A++ Y +M+Y+LK SELA SDL++YYKALD+AIMSYH VKMA++NKI++ELWR+TY G DIDYIEICS+E+++ A RRTYNYRVVMVK G ARLDMRGRCSAGQKVLA L+IRLALAEVFCLHCGVLALDEPTTNLD ENI SLA++LVEII NRS+Q NFQLIVITHDE+FV LL RSDYV+N++
Sbjct: 1 MALIERMSILGIRSFGQETSQKIEFFTPVTLILGQNGTGKTTVIECLKYSATGELPPGSKTGCSFIHDPRIAQESEVKAKVTLQIRDVKGCPMVVSRALMATQRDKTKQGTLKTLDGSIKRQYSDGRVTSVSLRCTDLDQEMVTSLGVSKAVLENVIFCHQEDSNWPLQEAKSVKQRFDDLFASSRYVKALDAIRKCKQDNDGNVKLYKTELKHL-TKNRDEALKLRSEREETLHSIEKQEKNLEEMSAKLQPVVEQLNRYKERYAEL--TKLQAEIKSCEAERAHLTDTIKNLMLNIQNEYQGSDEELKRLIEDAETEYEKKIFLLNQSENILQRKRKELNTLETDQTKTIVEKTQIEMEVKRLN----EAIINRDMILASIVTNYIPGDMYADVKQFTDEDVEYIVQFVDGLLHEYENQLTEVKLLSANEERKAQTDVDVVRDELAALKQKIQTIKRNYNQRSCEMISVEKRLE----NEHSLN----------ERIEKVRDQFHKSEITIRDLNADHELNNLHQSITESLGKKKELEHTISLLDEKIATFQKSASKYRELELMQKERANKLEGIRKIRSRHAEALEQVFAGSVIPFVATEKSLEEQANPNNIRSFINDQTRLKVVFSKRLDELEQSTRETRKQLAKIEQERSSLEATSKFTRNHLQEKRDQLKILEGKLLSVPGADDLEQTLINLQDRRGSLEEEYANEQGSVFLWCKFRDRLSRVDSDCPVCHRCFDSDAERDELLNEIDNRIKTLPSEFERKKQELKEIVSRLESLVELRPISLEIKNLHEEIIPALELKIKAELDKLTDVRSQRDKTSALLETYQADESLAKTVQGDLAILERLENE-----------SYELTVKINQFKYEFTDITTDSQLIDGLQEERKSLRESLLTISETIEEKQKRVDQLNQAQREAVSKMHRLKDQMHKLQQENLDNVQLKNDLSRLTRDCEILKKELSELESE------QLPAVHRRWTEACDER-SRITKIREENIEQ-ATTKINEIGEKLKKLTDACTSVKFAFDSQPLERLKVILETVEEL----QKNLSLVKSEADTCSQNIELLKKQINEHKMRQRELADCVQVRQLRCHLNFLTERTESLAKNQMICDNIPLSDQDLIN-ETKRLSLEEEKLHSLKQDISN---QLSELNAKLCYLNRDLNE-KYTNADSEYRDMMYQLKTSELACSDLERYYKALDRAIMSYHAVKMADLNKIIRELWRSTYRGNDIDYIEICSEEDTAAALNVCRTRRTYNYRVVMVKTTTGSMSVSRPKSKNNTSCNNEARLDMRGRCSAGQKVLASLIIRLALAEVFCLHCGVLALDEPTTNLDRENIESLAYALVEIIKNRSRQKNFQLIVITHDEDFVELLGRSDYVENFF 1346
BLAST of DNA repair protein RAD50 vs. TrEMBL
Match: A0A3Q0KL19 (Putative dna repair protein RAD50 OS=Schistosoma mansoni OX=6183 PE=4 SV=1) HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0 Identity = 511/1419 (36.01%), Postives = 772/1419 (54.40%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKL-SERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKE--MIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENN---DWRKENYRLL--QEKGAVD-SKISEKNNKQHEFDVNIERFAGEINLSYDKDEADLAIRNIED----YIANLT--LKYRDEKKVLDNQLVIAEEKLESQKSSKI------TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETR-------ENLQRLMQSI-------RDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFD-NMIPETYLKKMLDQKL----------------LEFKNKHIEFQKLDRILQSKLSGFEFDLKQMK-DSAIKHQQLVDKFDE------DVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTS-----------KKKSIENELKDMKNKLEKERK-------IYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQT-QLRISQDKLTPVTCLLKEI--ITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHL---NSKIQNNLKAI----DDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGIL--------NAQLAGVDLLNIDSKMKELEKER-RQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGAST---KRRTYNYRVVMVKRHNG------------------ARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIK 3975
M+++E ++I GIRSF + +Q ++F PVTLILG NGTGKTT+IE L Y+ TG+LP GSKTG SF+HDP++ ESEVKAKV+L I+DVKG + ++RAL TQ+DK K +++TLD SI++ +G S+S +C D++ EM SLGVSKAVLENVIFCHQEDSNWPL EAK VK+RFD+LFAS+RYVKALD IRK K D + ++K YKTELK+L T D KL SER E E + + KL+P+ + +Y+ ++ +L TK Q EI E E + I++L NI S EL++L IE + + E I L+K N + RKE L Q K V+ ++I + + +E +N + I +Y ++ D YI L + E ++ + +L+ A E+ ++Q + + +I KR+ NQ+ N+ K+LE N LN +++E+V+ F+ E L L QSI ++LE+ I D I +Q KY E++ + ++R+ K ++++RSR + L +F ++IP +K L+++ + F + E ++ R + +L+ E + ++ S L +K D+ + + G DL +L ++++ LEEE Q SV L+ KF+D L + SDCP+CHR F D+E D+L++EI+ + PSE R EL I + SL +L S +I++L E +I LE K + ++ D++ + S E +E +A ++ GD+A +E+ +E +LT+ +FK EF +T+ ++KS+ L + +++++K ++ ++ ++L +++++ ENL+ + + S L E L +E++ L++ QL + + T I I E+N I TK+ I +LN A + + ++ + +Q NL + D I L ++N HK+R RE D +Q+R ++ + E L N L+ DL+N ++K LE+E+ +K+ I + + + +N ++ Y+ +DLN+ + +A+ Y +M+Y+LK SELA SDL++YYKALD+AIMSYH VKMA++NKI++ELWR+TY G DIDYIEICS+E+++ AS RRTYNYRVVMVK G ARLDMRGRCSAGQKVLA L+IRLALAEVFCLHCGVLALDEPTTNLD ENI SLA++LVEII +RS+Q NFQLIVITHDE+FV LL RSDYV+N++ + G S+I+
Sbjct: 1 MALIERMSILGIRSFGQETSQKIEFFTPVTLILGQNGTGKTTVIECLKYSATGELPPGSKTGCSFIHDPRITQESEVKAKVTLQIRDVKGCPMVVSRALMATQRDKTKQGTLKTLDGSIKRQYPDGRVTSVSLRCTDLDQEMVTSLGVSKAVLENVIFCHQEDSNWPLQEAKSVKQRFDDLFASSRYVKALDAIRKCKQDNDGNVKLYKTELKHL-TKNRDEALKLRSEREETLHSIEKQEKNLEEMSAKLQPVVEKLNRYKERYAEL--TKLQAEIKSCEAERAHLTDTIKNLMLNIQNEYQGSDEELKRL----------IEDAETEYEKKIFLLNKSENILQNKRKELSTLETNQTKTIVEKTQIEMEVKRLNEAIINRDMILASIVTNYIPGNKYADVKQFTDADVEYIMQFVDGLLHESENQLTEVKLLSANEERKAQTDVDLVRDELAALKQKIQTIKRNYNQQSCEKVNIEKRLE----NEHSLN----------ERIEKVKDEFHKSEITVKDLNMDHELNNLHQSITESLGKKKELEHSISLIDEKIATFQKSANKYRELELVQKERANKLEGIRKIRSRHAEALEQIFSGSVIPFVATEKSLEEQANPNNIRSFINDQTRLRIVFSKRLNELEQSTRETRKQLAKIEQERSSLEATSKFNRNHLQEKRDQLKILEGKLLSVPGADDLEQTLINLQERRGSLEEEYANEQGSVFLWRKFRDRLSRIDSDCPVCHRCFDSDAERDELLNEIDNRIKTLPSEFERKKQELKDIVSRLESLVELRPISLEIKNLHEEIIPALELKIKAELDKLTDVRSQRDKTSALLETYQADESLAKTVQGDLAILERLENE-----------SYELTVKINQFKYEFTDITTTDSQLIDVLQEERKSLRETLLTLSQTIDQKQKRVDQLNQAQREAVSEMHRLKDQLHKLQQENLDNVQLKNDLSRLTRDCETLKKELSELESEQLPVVHRRWTKACSERSRIAKICEQN----------------IEQATTKVNEIGEKLKKLNDACTSVEFALNSQPLERLKTILETAEGLQKNLSLVKSEADTCSENIELLKKQVNEHKMRQRELADCVQVRQLRCQLNFLTERTESLAKNQMICDNIPLSDQDLIN-ETKRLALEEEKLHSLKQDISN---QLSELNAKLCYLNRDLNE-KYTNADNEYRDMMYQLKTSELACSDLERYYKALDRAIMSYHAVKMADLNKIIRELWRSTYRGNDIDYIEICSEEDTAAASNVCRTRRTYNYRVVMVKTTPGSMSVSRPKSKSYTSCSNEARLDMRGRCSAGQKVLASLIIRLALAEVFCLHCGVLALDEPTTNLDRENIESLAYALVEIIKSRSRQKNFQLIVITHDEDFVELLGRSDYVENFFLLSRDAQGLSEIR 1360
BLAST of DNA repair protein RAD50 vs. TrEMBL
Match: A0A0X3NZI8 (Zinc-hook domain-containing protein (Fragment) OS=Schistocephalus solidus OX=70667 GN=TR151247 PE=4 SV=1) HSP 1 Score: 668.307 bits (1723), Expect = 0.000e+0 Identity = 473/1399 (33.81%), Postives = 756/1399 (54.04%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINLS-----------YDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKET--RENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLF----------------------DNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQ---------------QLTLSAEEFKIEFEKV--------TSKKKSI--ENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLA--------GVDLL-NIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEE---SSG--ASTKRRTYNYRVVMVK-----------RHNG-------------ARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQI 3972
MSVLE ++IQGIRSF P+N Q ++F PVTLILG+NGTGKTTIIE L YA TG+LP G+KTG SF+HDP++A EVKAKV+L +KDV+G + ++R+L T ++K+K +++TLD SI++ + NGE +S+SS+C +++ EM+ SLG SKAV E+VIFCHQE+SNWPL EAK VK+RFD+LFAS+RYVKALD IRK +L++E + K K ELK+L + +++ +R + QR + ++S V +L+PI A + YR ++++L + + + +EK +E +++DL NIS + + +L++ I +++ LL+ + ++ E ++ ++ ++ + LL +K ++ +I N + I R AG + L+ ++ R ++ + + + D K + + A+ + +++ + E I + +L + K + +KL I S +L N L E ++ E ++ NS ET + L L + E I D I Q +E + L + R K +++LRSR D+ LF + +P + K+ D + K +E KL+R S + F KQ+ + Q + + +E + CG+ DL + + +K +L E + S+ L+ KF+D L ++S+CPLCHR F +D++ +DL +E+ +K P +L EL I++ +L +L S L+E + L+TK + +L+ +I + + E ++ +A S+ GDVA MEK+ EI + ++I+ L+ L S +E E +V K+++I EN L+D +++LE+E ++ TN LN E+ R+ + N + ++L++W + QL + L ++I+ R+ L + +I +E + R +K +++ + L ++ I L ++ + + +D L I NHK+ RE +D +++R ++ + L +++A DLL +++S E ++ R+Q + +D R T++ T+++ + + L + + DAET Y++ VY++K +E+A +DL+ +Y ALD+AIMSYH KMAE+N+I+++LWR TY G DIDYIEICS+EE +SG A+ +RRTYNYRVVMVK R G ARLDMRGRCSAGQKVLA L+IRLALAEVFCL CGVLALDEPTTNLD ENI SLA++L EII RS Q NFQLIVITHDE+FV LL R+D + +RI + G S+I
Sbjct: 13 MSVLEKMSIQGIRSFGPENPQRIEFFTPVTLILGTNGTGKTTIIECLKYAITGELPPGAKTGVSFIHDPRLAHLPEVKAKVALQVKDVRGCPLIVSRSLLATHREKSKQGTLKTLDGSIKRQLPNGEIVSLSSRCGELDREMSTSLGASKAVFESVIFCHQEESNWPLLEAKSVKQRFDDLFASSRYVKALDAIRKTRLEQEGNAKIGKAELKHLSRSREEAHQVRGQRTDTQRALDTEEKRLSDVIARLDPISADLTLYRKKYSELVQYQTEARSCESEKIQLEKRLQDLLDNISNEFSGTDEDLKEAIEQAEVQLLSKQNTMSSTECSLKTIQRQIESKEGKRSGLLVKKTQLEVEIKRINESTERRNELIVRLAGMLGLTEVVSRQGLMKELSAEDVAAVKRGLQASLNSAEKRLTDIKTSTEGEEKQAQTAVYEARAALVRVEQSICAAETALKENAKESAEVKRKLSRIATFSAELEEVNQKLKEAREAREALE---NSSETADKAALDSLAARRAEAEASIASLDAKIGDLQRYAMVNHEREMLQKNRQSKVDAVRKLRSRHLDMFEQLFAGQPVPQVCAALSATEDPAVSSGSTLPREFAKRFADL-VASAKETQLELNKLERERSSVEAALSFQRKQLHEK----QDMARQMEERLLSACGSVDLERHIDKLLLRKKQLSSECANDEGSLYLWKKFRDRL-AHESECPLCHRNFDNDNDYEDLKNELEQKITSMPRDLQSKKRELENIEKQHQNLIELRPVSQDFSVLQETELPTLKTKVDSSNARLEELKGAIDKETTKLEFIQADQSIAQSLQGDVAVMEKFEKEIVDLSRSIQRLKPDNESQSLDDLHAQRDALRASCKELSEEIAQVRRKLDGHMMKKQQAINTENSLRDTQHRLERE---HQALTN----LNSELERLAAVNSRLSEELKDW-----------------RAQLPACNETLASAEARRQKILQARDEGLAIAQVETQEWRDRIREFEESCSAAQPLRGH-SKETYDSVVQQLLELDSGIAALKDEVVRSSEDLDG-------LRKSIANHKIYQRELQDCVRLRDVRGQLASTALRVKTLQSKIAEYQSSASGATDLLQHVNSLSSEEDRLRKQKQVVVD----RVTQLQTELKMLERSLAE-KYADAETEYVKKVYEVKTAEMAATDLELFYHALDRAIMSYHASKMAEVNQIIRDLWRTTYRGNDIDYIEICSEEEPFSASGANAAKQRRTYNYRVVMVKASSASMASGSQRLGGNSRSNKSARISSEARLDMRGRCSAGQKVLASLVIRLALAEVFCLQCGVLALDEPTTNLDRENIESLAYALTEIIKTRSGQRNFQLIVITHDEDFVELLGRADCASHLFRISRNLQGLSEI 1365
BLAST of DNA repair protein RAD50 vs. TrEMBL
Match: A0A158QIZ8 (AAA_23 domain-containing protein OS=Rodentolepis nana OX=102285 GN=HNAJ_LOCUS10603 PE=4 SV=1) HSP 1 Score: 628.632 bits (1620), Expect = 0.000e+0 Identity = 467/1362 (34.29%), Postives = 743/1362 (54.55%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESN---INSLDKENNDWRKE----NYRLLQEKGAVDSKISEKNNKQHEFDVNIE------RFAGEINLSYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLF--DNMIPETYLK-------------KMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISI-AQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSS-------LQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERN-SKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKA--IDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRK------TRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEES---SGASTKRRTYNYRVVMVKRHNG-----------AR--------LDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSP 3954
MS LE + IQGIRSF P+N Q + F PVTLILG NGTGKTTIIE L YA TG+LP G+KTG SF+HDPK+ EVKAKV+L +KDV+ + R L TQ+ K S++TLD +I++ +G S S + +++ EM NSLG SKAV ENV+FCHQEDSNWPL EAK VKERFD+LFAS+RYVKALD +RK + D E + Y+ ELK+L + +++N + + +R E + ++S V +L+PI A + YR ++ +L E + + ++K +E +++L I+ S EL + I +D L ++S+ + E+N I S K N+ + E RL E +D + ++N V +E +FA E LS + + R++ED + K L++ A++K++ S+ + E I + +L++ + + KL+ S +L + L E E ++S+ + E +++++R E+QI D I+K Q + + +L R ++LRSR D L +F + IP+ +K K ++ +LE K ++ + L + F KQ+++ Q + K +E + CG +L +SL +K +LE + T + S+ L+ +F+D L K +SDCPLCHR F ++ + DL +EI + + P +L+ EL ++ + +L +S + +L+E I +L+ K + + + DLQ+ + + S+ +I E +A + GD+A +EK EI + +++ + S++ + EK+T K + ++++ ++ ++E+ K +++ +KE++L +L ++K+ Q S+ L+ KE ++ L+ QL Q L+ ++II ER+ S F ++ + + E V + RT + + E L+ + ++ L K + LK+ +D S+ + QL IN H++ R+++D +Q+R K++ +G L+ +++ +I K+ + I E ID E ++ TR+ T+++ + KDL + + DAE Y++ +Y+ + SE+A +DL +Y++ALD+AIM YH+ KM EIN+I++ELWR TY G DID+I+ICS+EES + AS RRTYNYRVVMVK +G AR LDMRGRCSAGQKVLA L+IRLALAEVFCL CGVLALDEPTTNLD ENI SLA++L EII RS Q NFQLIVITHDE+F+ LL R+ ++ R+ +P
Sbjct: 1 MSKLEEMRIQGIRSFGPENPQQISFSTPVTLILGPNGTGKTTIIECLKYAVTGELPPGAKTGASFIHDPKLTSSVEVKAKVALKVKDVRNCSMVAARNLVATQRGTAKAPSLKTLDGAIKRVNPDGTVTSRSLRVGEMDAEMVNSLGASKAVFENVVFCHQEDSNWPLQEAKSVKERFDDLFASSRYVKALDALRKSRTDLEAKAREYRAELKHLTRSKDEANQVRHRKADRERDLEGKMEELSRVDQELDPICAQLTLYRKKYKELVEYQATSKSLSDQKRNLEEGLKELNNKITKKFEGSDEELNEAIEKADEQLAEWQRSLIRNETNLKEIQSFVKANDQTKHELVISRTRLDIEVQRLDEALKKRNEVIGNLAVTMELTDIADKFANERELS--NSDVETVKRHLEDAVKISESHLNKAKGALESDGRKAQKKVDEALSALVRVEQSITNQESALSEYVEKWSDFDNKLKRASSASGELEAVKKKLDEATSSRELLESSESESELKKSIERAQTERNSYEDQIAYLDAQIDKAQRNAMANQKRVTLESDRMNAIEAARKLRSRHLDQLEIIFAGEEAIPQVNVKGGKSANSLTREFNKRFEKLVLESKGIQTNLNEMQKELSKLETQLSFHRKQLREK----QDTMRKIEESLISTCGRVNLEHSLDALMIRKKQLEGDCATEEGSLYLWKRFRDRLAK-ESDCPLCHRGFTNEQDHIDLKEEIERRIVSIPLDLDSKRKELQELTSQHEKIIELRPKSVEFSNLREVDIPELDAKIKATQLNLDDLQLKMETETSKLADIQM-KESVARKLQGDMAVIEKTEQEIGDLTRSLDSCKGSHGESSKWLGVVEEKIT---KDLSSKIEGLRTEMEQLSKQRQNAIDKEHELK-------DRHLKLEKEFQAVSTLNSELKRLEASKERTTSQLEELRAQLAGCQASLSAAEVDKRKIIEERDESVAFATAEWQEWRERIREFMEVCESVASKYRT------NSSPIEELQRVARELARLEEK-REELKSREVDISQE-VEQLRTAINTHQIVQRDFQDCVQLR-------KLQSQLGSLSGRIS-----DIQGKITACQS---GISESIDPEEHKQVINEGITRVKTELQMMEKDLKE-KYADAEAEYVKKMYEFRTSEMAATDLHRYHQALDRAIMKYHEEKMNEINEIIRELWRTTYRGNDIDHIKICSEEESLATAAASRTRRTYNYRVVMVKAGSGGGAVPTRVGKYARLTTSSETPLDMRGRCSAGQKVLASLVIRLALAEVFCLQCGVLALDEPTTNLDRENIESLAYALTEIIKARSSQRNFQLIVITHDEDFIELLGRAGCANHLQRLVRNP 1320
BLAST of DNA repair protein RAD50 vs. TrEMBL
Match: A0A2C9JC49 (Zinc-hook domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106076215 PE=4 SV=1) HSP 1 Score: 625.55 bits (1612), Expect = 0.000e+0 Identity = 435/1331 (32.68%), Postives = 738/1331 (55.45%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQF--LKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSK-TGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDK-NKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEK---YRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVD--SKISEKNNKQHE---FDVN-IERFAGEINLSYDKDEADLAIRNIEDYIAN-----LTLKYRDEKKVLDNQLVIAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKM----LDQKLLEFKNKHIEFQKLDRILQSKLS---GFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDD-EINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICS--DEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKI 3978
MS LE + IQGIRSF P F LKF P+TLILG NGTGKTTIIE L YATTGD+P G K G +F+HDPK+ E E+K ++ L I+DV G + +TR++ + KD K + M+TLD + + + +GE SI+S+CAD+N+EM +LGVSKAVLENVIFCHQEDSNWPL E K VKE+FD +FAS RY K LD I+K+K ++ IK K EL+YL+ + + ++++ + + + + +LEP+ A + K ++N+ KL +K++ V+EKE IE ++DL++ I EL+K + D + + + ++E+ + L E + K +L EKG ++ ++I+ +N K+ + F+V + F G S ++ +D + +++ + L R + + + + I +EK+++ K +K E+ M+K ++ + E + ++ +KL + ++ +L S +DL+ ++ +L EV+++ N + R + L + + L+ I + + IN+ ++D L+ + EK S ++RLR D +++L + IP L++ + + K ++E K +L SK + L+Q +D + ++ +Y +C + DL E + ++ +EE +L + + K+ L+KN CPLC R FQ EV +LI ++ E+ K P + + ++ + Q ++ +L ++ LKE I +L++K + E+ ++ I Q +D+ I + ++A D+ +M++ E++ +++ I+ Q+ L + E+V +++ + EL M L+ R D + KL +++ + SE L ++ +LQ+ L+ +K L + + Q + ++ ++ P+ +++++ E+ + +A++ + + K +K TE+ + L+ K L+++ + +++ + ++ +I+N ++R RE +D L +R+ E++ +E I L +L G+D+ ++ + L ++ ++ ++ + R+ QI+ + DLN K+AE Y V ++K +E+ DL KYY ALDKAIM YH+ KM EIN I++ELW+NTY G DI+ I I S DE ++GA RRTYNYRVVM R NG LDMRGRCSAGQKVLA ++IRLALAE FC +CG+LALDEPTTNLD NI SLA +LV +I R Q +FQLI+ITHDE+FV LL RS+YVD Y ++ +P G S++K+
Sbjct: 1 MSTLERMGIQGIRSFGPDEVDFQSLKFFTPLTLILGPNGTGKTTIIECLKYATTGDMPPGCKGAGAAFIHDPKLCKEREIKGQIRLMIQDVSGAKLMVTRSMNSKLKDSTGKKIEMKTLDGVLTRSLPDGEKQSITSRCADLNIEMIGALGVSKAVLENVIFCHQEDSNWPLGEGKTVKEKFDAIFASTRYTKVLDEIKKLKQAQDQEIKEGKKELEYLKQLKTKAEELRNSLDDIESKFAASVDSVEKINGELEPVRAELLKINTHQNEIFKLQTSKQK---FVSEKEHIEKSMKDLKEKIKENFTGPTTELKKELRDFSEKVQEKKDELSEQENQQDRLVSELDKLAKTKSNVLMEKGKLEKEAEINAENIKKRDAKIFEVAAMYDFEG---FSKGQEISDELYQRFFEFVKEKLTSLMELGKRKKAEFEEKENRI-QEKIDALKENKTKLEHGEKMHKDTIAKNEIEIKDINRKLTKMITSADRLESLKSDLNRVENQLHEVEASLNVDDARAEIASLDKQKKLLDASISELNTEINRLTKQSAVQTQLDMLISNQQEKESTIERLRQLHEDSIVSLLGH-IPLDNLREAVSDYISNQTETVKKINLELNKQKTLLSSKQAEKNSLGTQLRQKEDE-------LRTLEDKIYNVCESQDLDEEFNEVQKNLTQAQEEKGSLLGADHMIKKYIRNLEKNNPCCPLCTRGFQQAQEVRELILKLQEQLRKVPINIKKADEDVEKYQQKYDAIMQLKPLKEKSVSLKEIDIPELKSKIKKLDDELKSIK-DIIQTKEDEVSIQETDLQIAKGFHPDIIDMDRRRGEVRELERKIEA--QRALLLGGGSNRQIEQVMKEREEKQLELDTMNRTLDSRRDKLSDFQEQTQKLRSKVHSLQSEKLGLEGELQQKIKLEERKTTLASDNKNYQRDIDEAKSQIRPIDSQIQKLLEEKGEVTNSKDKMMENARADVETVKNKGTSVKNLNTEIKNYNQSGKLDKLKVCLKKEKELDAEKLKKGELLEELSVAVKKITNEISNQQIRERELQDILLLRNKEEEVKSLEVKIAELQTKLGGLDVKTLEKDRQALLRKETELNQKQSTALGRQQGFKDQIKSVKNDLNSDMYKEAEKKYKTKVIEIKTTEIVNMDLQKYYSALDKAIMMYHKAKMEEINVIIQELWKNTYRGNDIETILIQSEVDETTAGAMKNRRTYNYRVVM--RRNGIDLDMRGRCSAGQKVLASIVIRLALAETFCTNCGILALDEPTTNLDRANIESLAIALVSVIKERQSQRHFQLIIITHDEDFVELLGRSEYVDEYIQVSKNPDGFSRLKV 1311
BLAST of DNA repair protein RAD50 vs. Ensembl Cavefish
Match: rad50 (RAD50 double strand break repair protein [Source:NCBI gene;Acc:103041254]) HSP 1 Score: 584.334 bits (1505), Expect = 0.000e+0 Identity = 401/1330 (30.15%), Postives = 734/1330 (55.19%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNEL--QRQAEVLITK--ISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEKLESQKSSKI--------TFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSK---LSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKF-QDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHSAN 3999
MS +E ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L Y T+GD P GSK G +FVHDPK A E++V+A++ L +DV G V + R++++TQK K P +TL+ I + M +GE +S+SSKCA+I+ EM ++LGVSKAVL +VIFCHQE+SNWPL+E K +K++FD +F++ RY+K L+ +R+++L + N++K+ + ELKYL+ + K E +L ++ ++ +K + ++++++P++ + + K+ + + + K+ +E R+LE+ + S +L+++ + + E+ + + + + +E + LL E+G + + D ++ A + + Y++ + R ++ + + E + L+ + +EK E+QK I E I + +K++ L N+ L+ + +ST+L +LS+ +++L+ + + +Q L + +L+ D + + ++D L + +++K +++++SR ND L+++ + + L+ + K E + + KL++ L S+ S F ++++ K QQL ++E ++ +CG+ D + L + +D K ++ L + ++Y++F + ++ + CP+C R F ++E+ D+I+++ K P +L +L + ++ + L + +L+E+ + +L K Q +EI L+ I + + + E A + L D++ M++Y ++K +++ K+ + L + + V+ +K+ ++ L +K+E +RK+ +D + L +N I SE L I ++Q+ L+ Q L EI +L ++R ++++++P+ +++ E+ + + + KI+ + +++ + E+ + E N+ E ++ N+++ K + I + I+ KV+ R +D L +R E++ ++ + +L ++ + ++ + S+ +ELE++ +K+ R+ +I K+L + + AE + + + ++ +ELA DLD YYKALD+ IM +H +KM EINKI+++LWR+TY G+DI+Y+EI SD +E++ A KRRTYNYRVVMVK LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+LALDEPTTNLD ENI SLAH+LVEII +RS+Q NFQL++ITHDE+FV LL RS+YV+++YRI + S+I C I S N
Sbjct: 1 MSKIEKMSILGVRSFGVEDKDKQVISFFSPLTVLVGPNGAGKTTIIECLKYVTSGDFPPGSK-GNTFVHDPKDAHETDVRAQIRLQFRDVNGQAVAVQRSMQSTQKGKKAP-EFKTLEGVITR-MKHGEKVSLSSKCAEIDREMISALGVSKAVLNHVIFCHQEESNWPLSEGKALKQKFDEIFSATRYIKVLETLRQLRLKQSNTVKSCQMELKYLKQ----NKEKAQEIKDLLSTKEGQLAASKESVQRIESQIDPLENRLNDIDDNLGKVMKLDNDIKALDSRKKQMEDDNRELEEKMEQVFQGSDEQLQEMYQNHQRTVKEKERRLTECQRELERAGRECQRMNRIKADLLVEQGRLQMEADRHALHIKNRDAQVKSLAAYLEMEGYER--TPFSERQLQSFHRQTKERQDQETEALNKIMTDMQEK-ETQKQQSIDEIRDKKTGLERTIELKGDIQAKKQQELKNIKSDLQRLEGSSTRLQELETELSKAERELDNAVQSSTVDSLKAEVQELQREKAELDQAQRRLDQEMEALNMHTTARTQMDMLKKDKTDKEDQVRKIKSRHNDDLVSVMGHFPNKRELEDWIYSKSREINSLREKLGKLNKELASREQNKSHFTAEIRR------KEQQLAS-YEEKLFNVCGSQDFESDLSKLQDDLDKCSKQRAMLAGATAVYTQFISQLTEEGEPCCPVCQRIFPSEAELQDVINDMQSKLRLVPDKLKNTEQDLKRKERKRDDMMALKPVRQSLAELQEKELPELRNKLQTVNREIEKLKGDIEEQESVLSMLMSEEDTAKACLQDISLMDRYQLDLKDVER--KIAQHAAKLQGVDLNRTMQNVSQEKQESQHRLDTTCSKMELKRKLIQDQQEQIQTLKSSVNEIRSEKLQISSNMQKQQQLEEQCVELSTEIQALHREIREAKEQVSPLATTFEKLQQEKQELIERRRQKQVEGQEKITAIKDRIKSLSSLEREITRYIEEGKNDYKEQKEAELQETNTQLIEAEKQREKINKDIGDIRQDIDTQKVQERWLQDNLTLRKRVEELKEVSKKREVLLKEMGNMKVIELRSERRELERKVEDLKKNRSVALGRQKGFEEEILRFRKELREDQYCQAEDRFRDRMIVMRTTELANKDLDIYYKALDQTIMKFHSMKMEEINKIIRDLWRSTYRGQDIEYVEIRSDVDENASAGVKRRTYNYRVVMVK--GDTALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILALDEPTTNLDRENIESLAHALVEIIKSRSRQRNFQLLIITHDEDFVELLGRSNYVEHFYRIRKNQDQCSEITKCNISSLN 1309
BLAST of DNA repair protein RAD50 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004623.1 (pep scaffold:Pmarinus_7.0:GL479832:11294:32717:1 gene:ENSPMAG00000004172.1 transcript:ENSPMAT00000004623.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 311.997 bits (798), Expect = 3.626e-89 Identity = 262/1052 (24.90%), Postives = 523/1052 (49.71%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKN--NQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISS-------VQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLVIAEEK-------LESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSD-CPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEI------ITER-----NSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTL 3138
M+ ++ ++I G+RSF + Q + F P+T+++G NG GKTTIIE L Y TGD P G+ +G SF+HDPKVA E++VKA++ L DV GD VT+ R L TQK K V +TL+ + + NGE SISSKC D+N EM +LGVSKAVL NVIFCHQEDSNWPL+E K +K++FD +F++ RY+KALD++ K++ D+ + ++ + +K LQ N + ELQR + ++ K+ + + ++ P++ ++ ++ + + + + + K +E RDL++ + + +L++ S + E+ +G+ + + +++E R L E+G + + + D ++ A E+ L Y L+ R + + + + + + L EEK ++ + K E+ + + + L K+ L+ +L + + +L ++L + + +LE + + ++ R LQR+ + D ++ + D ++ + + ++D +++ EK ++R+R R + L+T + + L+ LD++ E + H + Q L++ +L+ E + + + ++ + + +E ++E+CG DL + L +D+ + ++ L + ++Y++F L + S CP+C R FQ +S++ ++++++ K P +L EL++ + ++ +L ++ + E+ + +L + +EI L+ S+ + + E S DVA M+++ +++ +++ KV +Q L+ + + + V +K+ ++ +L ++ N LE +R E + N+L +N + E L + +Q +L+ L E + L+ Q++ +Q+++ P+ L+++ IT R N + + + + K+ I+Y + I R +LNK K + E+ L+ + +N ++ D IS + +I+ KVR R + T+
Sbjct: 1 MAKIDKMSILGVRSFGIGDCDKQVITFHTPLTILVGHNGAGKTTIIECLKYICTGDFPPGT-SGASFIHDPKVAHETDVKAQIRLQFMDVNGDKVTVQRLLHATQK--AKKVEFKTLEGVFTR-LKNGEKYSISSKCTDMNREMITALGVSKAVLSNVIFCHQEDSNWPLSEGKALKQKFDEIFSATRYIKALDSLSKVRKDQGSIVRELQAVVKLLQQNKNKA-------EELQRDLDDIVAKLEASRESVLTIDREVSPLEINLKDVESKLAVVVRLDNEVKATQSRKAQMEVDSRDLQEKMEQVFQGTDEQLQEAYSSHQRRVQEKERRLGERQRELERVNREVLRLRNVKGGLHVEQGKLQQEAERHASIMKRRDELVQTLASELGLDGYSS--VPLSDRQVSSFTKLVRERMEQDNNNVKRLLHEFEEKENEKQRQMDDTRERKTAAESSVQLKRELLGDKQAELEEKRAELGRLQSSGDRLQVVESELRDTEHQLEVAEGSSQAEGLRTELQRMQRERTDFDSLLRRLDHEMSTLNLHTQARTQLDMHNKEKVEKEEQIRRIRLRHDKTLVTFVGHFPSKGELEMWLDRRSQERRQLHAKIQGLNK----QLASAEQNKSHLTTELRRKEERLKENEEQLFELCGGRDLESDLLALQDQIERTNKQRAMLAGASAVYTQFISQLTEEGSPCCPVCQRAFQSESDLAEVVNDLQAKLRLVPDKLRATETELTRKQKRRDNMIQLKPVQQRVVETSEKELPELRNRLSSLNQEIQRLKNSLDEEETLQATLESEEDAVKSCQQDVALMDRFQSDLRELER--KVAQQMARLAGVDVERTLQVVGDEKQDVQRKLDNVNNALELKRLALETDVERINELRSRVNSVREERLRLATGMQRIQALRSVTAELEAETSDLKRQIQEAQEQVLPLEGTLRKLQQEKAEITARKTREHNQEARRITDLQDKNKNIITYMKEVDTYINSGRDQLNKKKELEMQEVAR-------ELSGEEENQVQIGRD----ISGIRQEIDTQKVRTRTHAHTI 1022
BLAST of DNA repair protein RAD50 vs. Ensembl Yeast
Match: RAD50 (Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress [Source:SGD;Acc:S000005194]) HSP 1 Score: 228.794 bits (582), Expect = 2.552e-61 Identity = 122/244 (50.00%), Postives = 161/244 (65.98%), Query Frame = 1
Query: 3259 ERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIH 3990
E +Q++ QIDSL + + +Y KD E NY + +L+ D+D Y KALD AIM YH +KM +IN+I+ ELW+ TY+G DID I+I SDE SS + K ++YNYRVVM K+ LDMRGRCSAGQKVLA ++IRLAL+E F +CGV+ALDEPTTNLDEENI SLA SL IIN R Q NFQLIVITHDE+F+ ++ + + D+++++ SQI+ I+
Sbjct: 1084 EMKQLQNQIDSLTHQ-----LRTDY----------KDIEKNYHKEWVELQTRSFVTDDIDVYSKALDSAIMKYHGLKMQDINRIIDELWKRTYSGTDIDTIKIRSDEVSS--TVKGKSYNYRVVMYKQ--DVELDMRGRCSAGQKVLASIIIRLALSETFGANCGVIALDEPTTNLDEENIESLAKSLHNIINMRRHQKNFQLIVITHDEKFLGHMNAAAFTDHFFKVKRDDRQKSQIEWVDIN 1308
BLAST of DNA repair protein RAD50 vs. Ensembl Nematostella
Match: EDO44239 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWC8]) HSP 1 Score: 265.774 bits (678), Expect = 1.837e-81 Identity = 134/215 (62.33%), Postives = 157/215 (73.02%), Query Frame = 1
Query: 3301 RKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICS-DEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRI 3942
R+ +I KDL +AE + + V +K +++A DL+KYYKAL++AIM YH +KMAEINKI+KE W NTY G DID IEI S DE+ SGAS RRTYNYRVVM+K LDMRGRCSAGQKVLA L+IRLALAE FCL+CG+L LDEPTTNLDEENI SLA+ L +I R Q NFQLIVITHDE FV LL R+D+VD YYRI
Sbjct: 2 RQKGFEEEIRRFQKDLRSEMYGNAEEKHRQKVIDMKTTKMASGDLEKYYKALNRAIMKYHSIKMAEINKIIKEYWINTYKGNDIDTIEIRSEDEDGSGASKARRTYNYRVVMIK--GDLALDMRGRCSAGQKVLASLIIRLALAETFCLNCGILTLDEPTTNLDEENIESLANQLANVIRTRQAQRNFQLIVITHDENFVELLGRADFVDFYYRI 214
BLAST of DNA repair protein RAD50 vs. Ensembl Nematostella
Match: EDO44237 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RWC6]) HSP 1 Score: 130.568 bits (327), Expect = 3.048e-35 Identity = 73/166 (43.98%), Postives = 95/166 (57.23%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNW 567
MS +E + + GIRS+ + ++F KP+TLI+G NG GKT VAGE EVK ++ L KDV G+YV +TR L Q K K + +T+D I + +G+ SISSKCA+IN EM + LGVSKAVLE VIFCHQE+SNW
Sbjct: 1 MSSIEKMQVCGIRSYSHQERCVIEFQKPLTLIVGHNGAGKT-----------------------------VAGEQEVKGQIKLKFKDVTGNYVVVTRTLVAQQ--KGKKLETRTMDGVIMR-EVHGQRQSISSKCAEINREMISFLGVSKAVLETVIFCHQEESNW 134
BLAST of DNA repair protein RAD50 vs. Ensembl Medaka
Match: rad50 (RAD50 double strand break repair protein [Source:NCBI gene;Acc:101172011]) HSP 1 Score: 552.747 bits (1423), Expect = 1.173e-173 Identity = 388/1335 (29.06%), Postives = 718/1335 (53.78%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQF----TKLSET-----------KRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLV-------IAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDC-PLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS ++ ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L YAT+G+LP GSK GG+FVHDP+ A E++V+A++ L DV G+ V+I R++ TQK KN + ++L+ I + M +GE +S+SSKC +++ EM +SLGVSK VL NVIFCHQE+SNWPL+E K +K++FD++FA+ +Y+KAL+ +R+++L + ++K + EL+YL+ N + +++A+++ +K S ++ ID IE N+ TKL + R++++ + KE++ET + S EL+ + + + E+ + + + +E + LL E+G + + + D + + + + YD+ + +E + ++T + EK+ + ++ ++ + K E + + + +K++ L ++ L+ + +ST+L + +L++ + L+ + N +E + ++ L + +L+ D + + +++ L + + +K +++++SR N+ L+TL + + L+ L K E KL++ L S +++ K QQL +E + +CG+ DL L + ++ K ++ L + ++Y++F L + + C P+C R F +S++ D+I+++ K P +L +L + ++ + L I ++E+ + +L + Q ++I L+ + + + E A S L D++ M++Y +++ +++ K+ +Q L + ++V+ +K+ +++L + +K++ +R + + ++ L E+N +E L + D+Q+ L+ Q EI +L +R ++++L P+T L+++ E+ S + + + KI+ +++ I E++K S+ ++ E ++ +++ K + + + I+ KV+ R +D L +R E++ ++ L + + +L + + +++E++ +K+ R+ +I + K+L + + AE Y + ++ +EL I+DL+ YYKALD+ IM +H +KM EINKI+++LWR+TY G+DI+Y+EI SD +E++ A KRR YNYRVVMVK LDMRGRCSAGQKVLA L+IRLALAE CL+CG+LALDEPTTNLD ENI SLA +LV+II +RS+Q NFQL++ITHDE+FV LL RS Y++++YRI + +S+I C I S
Sbjct: 1 MSKIDKMSILGVRSFGIEDKDKQVIAFFSPLTVLVGPNGAGKTTIIECLKYATSGELPPGSK-GGAFVHDPRDAHETDVRAQIKLLFTDVNGEKVSIQRSMSCTQKAKNN--TFKSLEQVITR-MKDGERVSLSSKCGELDREMISSLGVSKPVLNNVIFCHQEESNWPLSEGKALKDKFDSIFAATKYIKALETMRQLRLKQSVTVKECQVELRYLKE--NKEKAQQIRETVAKKEAQLMASKDS-----IQLIDGQIEPLENRLIEIDTKLGKVLRLDNDIRLLESRKKQMEQDNKELLET--------MEQVFQGSDQELQDVYQNHQRTVKDKERRLADCQKELERAGRECQRLNRVKADLLVEQGRLQLEADRQMQCIKNRDTQVRSLSSYLEMEGYDR--SPFTALQLESFHRHVTQRLEQEKETFSQAMADLQEKEQQKQQSIDEMRDKKTGLERTVELKRDMQGKKQQELRSIRADLQRLEGSSTRLQELDNELTKAEHDLQSAVQSSNVEELKVEVEELQKEKSELDRTQRQLDQEMQTLNVHTTARTQMEMLKKDKLDKEEQIRKIKSRHNEDLVTLLGHFPNKRELEDWLYSKSKEINGTRDRLAKLNKDLASNEQNKSHTAAELRK---KEQQLTSD-EEKFFNVCGSQDLEQDLGKLQEDLEKASKQRAMLAGATAVYTQFISQLTEEREPCCPVCQRTFPSESDLQDVINDMQSKLRLVPDKLKNTEQDLKRKERKRDEMMALRPVRQSIVQVQEKELPELRNRLQTVNRDIERLKADVEKQETLLSRLMSEEDTAKSCLQDISLMDRYMMDLREVER--KIAQQAAKLHGVDLNRTIQQVSQEKQETQHKLDTISSKMDLKRNLIQSQQDQIQMLKSEVNERKAEKLQLSSDMQKQQQLEEQCVEFTTEIQALTRDIREAKEQLAPLTAALEKLQQEKQSLMELKKQKQEEGREKINGINERVKAITTLEREIHKYVSDGKDQYKEQKESELQETTTQLHEAEKQKEKINKEMGNIRQDIDTQKVQERLLQDNLTLRKREEELREVVAKHEALLKDIGNMQVLQLRQERRDVERKLEDLKKNRSIALGRQKGFEDEILHHRKELREDQYDKAEERYKNKMITMRTTELVINDLNLYYKALDQTIMKFHSMKMDEINKIIRDLWRSTYRGQDIEYVEIRSDVDENASAGVKRRVYNYRVVMVK--GDTALDMRGRCSAGQKVLASLIIRLALAETLCLNCGILALDEPTTNLDRENIESLALALVDIIKSRSRQRNFQLLIITHDEDFVELLGRSSYIEHFYRIRKNQDQNSEIAKCSISS 1306
BLAST of DNA repair protein RAD50 vs. Ensembl Medaka
Match: rad50 (RAD50 double strand break repair protein [Source:NCBI gene;Acc:101172011]) HSP 1 Score: 552.747 bits (1423), Expect = 1.173e-173 Identity = 388/1335 (29.06%), Postives = 718/1335 (53.78%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQF----TKLSET-----------KRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLV-------IAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDC-PLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS ++ ++I G+RSF + K+ Q + F P+T+++G NG GKTTIIE L YAT+G+LP GSK GG+FVHDP+ A E++V+A++ L DV G+ V+I R++ TQK KN + ++L+ I + M +GE +S+SSKC +++ EM +SLGVSK VL NVIFCHQE+SNWPL+E K +K++FD++FA+ +Y+KAL+ +R+++L + ++K + EL+YL+ N + +++A+++ +K S ++ ID IE N+ TKL + R++++ + KE++ET + S EL+ + + + E+ + + + +E + LL E+G + + + D + + + + YD+ + +E + ++T + EK+ + ++ ++ + K E + + + +K++ L ++ L+ + +ST+L + +L++ + L+ + N +E + ++ L + +L+ D + + +++ L + + +K +++++SR N+ L+TL + + L+ L K E KL++ L S +++ K QQL +E + +CG+ DL L + ++ K ++ L + ++Y++F L + + C P+C R F +S++ D+I+++ K P +L +L + ++ + L I ++E+ + +L + Q ++I L+ + + + E A S L D++ M++Y +++ +++ K+ +Q L + ++V+ +K+ +++L + +K++ +R + + ++ L E+N +E L + D+Q+ L+ Q EI +L +R ++++L P+T L+++ E+ S + + + KI+ +++ I E++K S+ ++ E ++ +++ K + + + I+ KV+ R +D L +R E++ ++ L + + +L + + +++E++ +K+ R+ +I + K+L + + AE Y + ++ +EL I+DL+ YYKALD+ IM +H +KM EINKI+++LWR+TY G+DI+Y+EI SD +E++ A KRR YNYRVVMVK LDMRGRCSAGQKVLA L+IRLALAE CL+CG+LALDEPTTNLD ENI SLA +LV+II +RS+Q NFQL++ITHDE+FV LL RS Y++++YRI + +S+I C I S
Sbjct: 1 MSKIDKMSILGVRSFGIEDKDKQVIAFFSPLTVLVGPNGAGKTTIIECLKYATSGELPPGSK-GGAFVHDPRDAHETDVRAQIKLLFTDVNGEKVSIQRSMSCTQKAKNN--TFKSLEQVITR-MKDGERVSLSSKCGELDREMISSLGVSKPVLNNVIFCHQEESNWPLSEGKALKDKFDSIFAATKYIKALETMRQLRLKQSVTVKECQVELRYLKE--NKEKAQQIRETVAKKEAQLMASKDS-----IQLIDGQIEPLENRLIEIDTKLGKVLRLDNDIRLLESRKKQMEQDNKELLET--------MEQVFQGSDQELQDVYQNHQRTVKDKERRLADCQKELERAGRECQRLNRVKADLLVEQGRLQLEADRQMQCIKNRDTQVRSLSSYLEMEGYDR--SPFTALQLESFHRHVTQRLEQEKETFSQAMADLQEKEQQKQQSIDEMRDKKTGLERTVELKRDMQGKKQQELRSIRADLQRLEGSSTRLQELDNELTKAEHDLQSAVQSSNVEELKVEVEELQKEKSELDRTQRQLDQEMQTLNVHTTARTQMEMLKKDKLDKEEQIRKIKSRHNEDLVTLLGHFPNKRELEDWLYSKSKEINGTRDRLAKLNKDLASNEQNKSHTAAELRK---KEQQLTSD-EEKFFNVCGSQDLEQDLGKLQEDLEKASKQRAMLAGATAVYTQFISQLTEEREPCCPVCQRTFPSESDLQDVINDMQSKLRLVPDKLKNTEQDLKRKERKRDEMMALRPVRQSIVQVQEKELPELRNRLQTVNRDIERLKADVEKQETLLSRLMSEEDTAKSCLQDISLMDRYMMDLREVER--KIAQQAAKLHGVDLNRTIQQVSQEKQETQHKLDTISSKMDLKRNLIQSQQDQIQMLKSEVNERKAEKLQLSSDMQKQQQLEEQCVEFTTEIQALTRDIREAKEQLAPLTAALEKLQQEKQSLMELKKQKQEEGREKINGINERVKAITTLEREIHKYVSDGKDQYKEQKESELQETTTQLHEAEKQKEKINKEMGNIRQDIDTQKVQERLLQDNLTLRKREEELREVVAKHEALLKDIGNMQVLQLRQERRDVERKLEDLKKNRSIALGRQKGFEDEILHHRKELREDQYDKAEERYKNKMITMRTTELVINDLNLYYKALDQTIMKFHSMKMDEINKIIRDLWRSTYRGQDIEYVEIRSDVDENASAGVKRRVYNYRVVMVK--GDTALDMRGRCSAGQKVLASLIIRLALAETLCLNCGILALDEPTTNLDRENIESLALALVDIIKSRSRQRNFQLLIITHDEDFVELLGRSSYIEHFYRIRKNQDQNSEIAKCSISS 1306
BLAST of DNA repair protein RAD50 vs. Ensembl Medaka
Match: rad50 (RAD50 double strand break repair protein [Source:NCBI gene;Acc:101172011]) HSP 1 Score: 482.641 bits (1241), Expect = 5.912e-148 Identity = 365/1335 (27.34%), Postives = 689/1335 (51.61%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSF--DPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQF----TKLSET-----------KRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINL-SYDKDEADLAIRNIEDYIANLTLKYRDEKKVLDNQLV-------IAEEKLESQKSSKITFENEINMNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDC-PLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSD-EESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHS 3993
MS ++ ++I G+RSF + K+ Q + F P+T+++G NG GKT A E++V+A++ L DV G+ V+I R++ TQK KN + ++L+ I + M +GE +S+SSKC +++ EM +SLGVSK VL NVIFCHQE+SNWPL+E K +K++FD++FA+ +Y+KAL+ +R+++L + ++K + EL+YL+ N + +++A+++ +K S ++ ID IE N+ TKL + R++++ + KE++ET + S EL+ + + + E+ + + + +E + LL E+G + + + D + + + + YD+ + +E + ++T + EK+ + ++ ++ + K E + + + +K++ L ++ L+ + +ST+L + +L++ + L+ + N +E + ++ L + +L+ D + + +++ L + + +K +++++SR N+ L+TL + + L+ L K E KL++ L S +++ K QQL +E + +CG+ DL L + ++ K ++ L + ++Y++F L + + C P+C R F +S++ D+I+++ K P +L +L + ++ + L I ++E+ + +L + Q ++I L+ + + + E A S L D++ M++Y +++ +++ K+ +Q L + ++V+ +K+ +++L + +K++ +R + + ++ L E+N +E L + D+Q+ L+ Q EI +L +R ++++L P+T L+++ E+ S + + + K+ ++ + + + + +EL + ++ + +N ++ N + ID KV+ R +D L +R E++ ++ L + + +L + + +++E++ +K+ R+ +I + K+L + + AE Y + ++ +EL I+DL+ YYKALD+ IM +H +KM EINKI+++LWR+TY G+DI+Y+EI SD +E++ A KRR YNYRVVMVK LDMRGRCSAGQKVLA L+IRLALAE CL+CG+LALDEPTTNLD ENI SLA +LV+II +RS+Q NFQL++ITHDE+FV LL RS Y++++YRI + +S+I C I S
Sbjct: 1 MSKIDKMSILGVRSFGIEDKDKQVIAFFSPLTVLVGPNGAGKTD-----------------------------AHETDVRAQIKLLFTDVNGEKVSIQRSMSCTQKAKNN--TFKSLEQVITR-MKDGERVSLSSKCGELDREMISSLGVSKPVLNNVIFCHQEESNWPLSEGKALKDKFDSIFAATKYIKALETMRQLRLKQSVTVKECQVELRYLKE--NKEKAQQIRETVAKKEAQLMASKDS-----IQLIDGQIEPLENRLIEIDTKLGKVLRLDNDIRLLESRKKQMEQDNKELLET--------MEQVFQGSDQELQDVYQNHQRTVKDKERRLADCQKELERAGRECQRLNRVKADLLVEQGRLQLEADRQMQCIKNRDTQVRSLSSYLEMEGYDR--SPFTALQLESFHRHVTQRLEQEKETFSQAMADLQEKEQQKQQSIDEMRDKKTGLERTVELKRDMQGKKQQELRSIRADLQRLEGSSTRLQELDNELTKAEHDLQSAVQSSNVEELKVEVEELQKEKSELDRTQRQLDQEMQTLNVHTTARTQMEMLKKDKLDKEEQIRKIKSRHNEDLVTLLGHFPNKRELEDWLYSKSKEINGTRDRLAKLNKDLASNEQNKSHTAAELRK---KEQQLTSD-EEKFFNVCGSQDLEQDLGKLQEDLEKASKQRAMLAGATAVYTQFISQLTEEREPCCPVCQRTFPSESDLQDVINDMQSKLRLVPDKLKNTEQDLKRKERKRDEMMALRPVRQSIVQVQEKELPELRNRLQTVNRDIERLKADVEKQETLLSRLMSEEDTAKSCLQDISLMDRYMMDLREVER--KIAQQAAKLHGVDLNRTIQQVSQEKQETQHKLDTISSKMDLKRNLIQSQQDQIQMLKSEVNERKAEKLQLSSDMQKQQQLEEQCVEFTTEIQALTRDIREAKEQLAPLTAALEKLQQEKQSLMELKKQKQEEGREKVKHH-SFVNPVSQKESELQETTTQLHEAEKQKEK-----INKEMGNIRQDID--------------TQKVQERLLQDNLTLRKREEELREVVAKHEALLKDIGNMQVLQLRQERRDVERKLEDLKKNRSIALGRQKGFEDEILHHRKELREDQYDKAEERYKNKMITMRTTELVINDLNLYYKALDQTIMKFHSMKMDEINKIIRDLWRSTYRGQDIEYVEIRSDVDENASAGVKRRVYNYRVVMVK--GDTALDMRGRCSAGQKVLASLIIRLALAETLCLNCGILALDEPTTNLDRENIESLALALVDIIKSRSRQRNFQLLIITHDEDFVELLGRSSYIEHFYRIRKNQDQNSEIAKCSISS 1258
BLAST of DNA repair protein RAD50 vs. Planmine SMEST
Match: SMESG000039247.1 (SMESG000039247.1) HSP 1 Score: 1658.66 bits (4294), Expect = 0.000e+0 Identity = 868/870 (99.77%), Postives = 869/870 (99.89%), Query Frame = 1
Query: 1390 MNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNXXXXXXXXXXXXXXXXXXXXXXXXXYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNKLEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSXXXXXXXXXXXXKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHSAN 3999
MNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNSLKEKRDKKSKLEEELLTLQSSVSLYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKN +EKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSENLNEMLENINIKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHSAN
Sbjct: 1 MNKRSLNQKEKALDNLGKKLEAIGYNSTKLNSNNADLSELKQKLEEVQSNFNSKETRENLQRLMQSIRDLENQIHDSDILINKYQIDEKKYNEIDSLVQQRSEKNSFLKRLRSRDNDILMTLFDNMIPETYLKKMLDQKLLEFKNKHIEFQKLDRILQSKLSGFEFDLKQMKDSAIKHQQLVDKFDEDVYEICGNYDLTNSLKEKRDKKSKLEEELLTLQSSVSLYSKFQDMLKKNKSDCPLCHREFQHDSEVDDLIDEINEKCIKAPSELNRITNELSQIDQVITSLFKLDTQSDQIRDLKERVIGDLETKCQIRKKEICDLQISIAQLSQDDEINSNNERMASSILGDVANMEKYNDEIKVIDKNIKVLEQQLTLSAEEFKIEFEKVTSKKKSIENELKDMKNNMEKERKIYEDSTNKENKLNIEINRITSENLNIQKDLQEWSSLQIQKENLIEEITSLQTQLRISQDKLTPVTCLLKEIITERNSKLFHLNNYESSAKSKISYYETKLEVIKRNRTELNKAKSENLNEMLENINIKIGHLNSKIQNNLKAIDDSKSLISQLNFKINNHKVRMREYKDTLQIRHHGEKIVKIEESIGILNAQLAGVDLLNIDSKMKELEKERRQIKEQIDSLEFRKTRINTQIEYIVKDLNDSRLKDAETNYLEMVYKLKVSELAISDLDKYYKALDKAIMSYHQVKMAEINKILKELWRNTYNGEDIDYIEICSDEESSGASTKRRTYNYRVVMVKRHNGARLDMRGRCSAGQKVLACLLIRLALAEVFCLHCGVLALDEPTTNLDEENIASLAHSLVEIINNRSKQTNFQLIVITHDEEFVNLLSRSDYVDNYYRIFTSPSGHSQIKICGIHSAN 870
BLAST of DNA repair protein RAD50 vs. Planmine SMEST
Match: SMESG000039215.1 (SMESG000039215.1) HSP 1 Score: 768.074 bits (1982), Expect = 0.000e+0 Identity = 389/389 (100.00%), Postives = 389/389 (100.00%), Query Frame = 1
Query: 70 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKXXXXXXXXXXTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINLSYDKDEA 1236
MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKLISDSDLILLTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINLSYDKDEA
Sbjct: 1 MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYATTGDLPAGSKTGGSFVHDPKVAGESEVKAKVSLTIKDVKGDYVTITRALKTTQKDKNKPVSMQTLDSSIQKCMANGETISISSKCADINVEMTNSLGVSKAVLENVIFCHQEDSNWPLTEAKQVKERFDNLFASARYVKALDNIRKIKLDKENSIKTYKTELKYLQTALNDSNTKLSERNELQRQAEVLITKISSVQTKLEPIDATIEKYRNQFTKLSETKRQREISVNEKEMIETQIRDLEKNISVPINYSAVELEKLISDSDLILLTIEQSVGKEESNINSLDKENNDWRKENYRLLQEKGAVDSKISEKNNKQHEFDVNIERFAGEINLSYDKDEA 389 The following BLAST results are available for this feature:
BLAST of DNA repair protein RAD50 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of DNA repair protein RAD50 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 4
BLAST of DNA repair protein RAD50 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 2
BLAST of DNA repair protein RAD50 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 1
BLAST of DNA repair protein RAD50 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 4
BLAST of DNA repair protein RAD50 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 2
BLAST of DNA repair protein RAD50 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of DNA repair protein RAD50 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of DNA repair protein RAD50 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 1
BLAST of DNA repair protein RAD50 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of DNA repair protein RAD50 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 1
BLAST of DNA repair protein RAD50 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of DNA repair protein RAD50 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 3
BLAST of DNA repair protein RAD50 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 2
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30019011 ID=SMED30019011|Name=DNA repair protein RAD50|organism=Schmidtea mediterranea sexual|type=transcript|length=4013bpback to top protein sequence of SMED30019011-orf-1 >SMED30019011-orf-1 ID=SMED30019011-orf-1|Name=SMED30019011-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1311bp MSVLESIAIQGIRSFDPKNNQFLKFLKPVTLILGSNGTGKTTIIESLNYAback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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