Elongator complex protein 4

Overview
NameElongator complex protein 4
Smed IDSMED30018912
Length (bp)1092
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Elongator complex protein 4 (SMED30018912) t-SNE clustered cells

Violin plots show distribution of expression levels for Elongator complex protein 4 (SMED30018912) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Elongator complex protein 4 (SMED30018912) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Elongator complex protein 4 (SMED30018912) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30018912

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30018912h1SMcG0005104 SmedASXL_012874SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Human
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171])

HSP 1 Score: 77.7962 bits (190), Expect = 4.280e-18
Identity = 67/263 (25.48%), Postives = 114/263 (43.35%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+     ++ PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 309

HSP 2 Score: 33.113 bits (74), Expect = 4.280e-18
Identity = 25/101 (24.75%), Postives = 48/101 (47.52%), Query Frame = 2 
Query:  791 VIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            +I  V ++ + V+  E+F   +   + L+ D  G I   +I  +N++      +    ++ + R+    +   LPP LSD  SRS++ + + S   L  GC
Sbjct:  313 IIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNL-ICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGC 412
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Human
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171])

HSP 1 Score: 76.6406 bits (187), Expect = 9.875e-18
Identity = 67/264 (25.38%), Postives = 113/264 (42.80%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR------DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+       + PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEQIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 310

HSP 2 Score: 33.113 bits (74), Expect = 9.875e-18
Identity = 25/101 (24.75%), Postives = 48/101 (47.52%), Query Frame = 2 
Query:  791 VIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            +I  V ++ + V+  E+F   +   + L+ D  G I   +I  +N++      +    ++ + R+    +   LPP LSD  SRS++ + + S   L  GC
Sbjct:  314 IIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNL-ICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGC 413
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Human
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171])

HSP 1 Score: 78.1814 bits (191), Expect = 2.453e-15
Identity = 67/263 (25.48%), Postives = 114/263 (43.35%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+     ++ PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 309
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Human
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171])

HSP 1 Score: 78.1814 bits (191), Expect = 2.961e-15
Identity = 67/263 (25.48%), Postives = 114/263 (43.35%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+     ++ PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 309
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Human
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:1171])

HSP 1 Score: 77.7962 bits (190), Expect = 2.989e-15
Identity = 67/263 (25.48%), Postives = 114/263 (43.35%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+     ++ PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 309
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Celegans
Match: elpc-4 (Putative elongator complex protein 4 [Source:UniProtKB/Swiss-Prot;Acc:Q18195])

HSP 1 Score: 48.9062 bits (115), Expect = 2.558e-6
Identity = 58/223 (26.01%), Postives = 95/223 (42.60%), Query Frame = 3 
Query:   87 STGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK---------FSSYSFHNINLSDNLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTIN 728
            S+G  S D L+ G L  ++I L++E +   + S L + F+A GL +     +      P+E I +      +     Q +P     NSL    EN M    IAWRY ++  V       +N  ++ D TK         ++   F    + + L + +   +   K  G    +  L+   L +    ICE + KFL    RFL CL+++   S + V +T N
Sbjct:   23 SSGCDSFDTLIGGALVNSSIVLIDEYRSRCYGSYLIRSFLAEGLHHGHRCFIADPTEDPKE-INLIPSRRTSTDMQNQEIP-----NSLPAENENSM---KIAWRYGNVKQVSSSLGPLSN-ENQYDFTKHVENPNVDVYAEKVFTLKGIYETLCQIVKENEAHTKSGGRGGPKKNLLRVVLKNIDMEICE-DYKFL---GRFLCCLRSLARSSYMIVYITAN 231
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Fly
Match: CG6907 (gene:FBgn0031711 transcript:FBtr0079096)

HSP 1 Score: 53.9138 bits (128), Expect = 1.232e-7
Identity = 38/142 (26.76%), Postives = 66/142 (46.48%), Query Frame = 3 
Query:   81 LLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTAL-VIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSSYSFHNI 503
            + S+G+  LD ++ GGL   +I L+EED+   H  +L ++F+A G+ + Q+  L  +D+I  E   ++ +            +  L    +     EN    L IAWRY DL  V  + A +  G     + +  S   +N+
Sbjct:   26 ITSSGNPYLDVVIGGGLPMGSICLIEEDRFMTHAKVLAKYFLAEGVISKQEIFLGSLDDIPAEMLRRLPRPLTDQESMEQSEVQALGDAGA-----ENG---LRIAWRYNDLPLVNSEHATAKIGHHFNLMEQMDSMMLYNV 159

HSP 2 Score: 41.5874 bits (96), Expect = 7.723e-6
Identity = 17/90 (18.89%), Postives = 51/90 (56.67%), Query Frame = 2 
Query:  779 FQSNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSN 1048
            + ++++  +R + +Y ++ E+F   +        + SG +   K++++N++  +  P T   ++ + R+K + ++F LPP L +++++ +
Sbjct:  331 YDASLVPKIRQLVDYAIELESFAGSERETHPAFKEYSGLLHLHKMSAINTLA-VHMPETPDLAFKLRRKKFIIEKFHLPPELQESSAKPD 419

HSP 3 Score: 26.9498 bits (58), Expect = 7.723e-6
Identity = 21/78 (26.92%), Postives = 34/78 (43.59%), Query Frame = 3 
Query:  492 FHNINLSDNLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTI 725
            FHN      LN+     +      G+     ++ ++SLGSPLW     +E F   + +FL  L A V       ++T+
Sbjct:  250 FHNPRYKGLLNDIQQLLRNESFVAGTKNNLCRVCLTSLGSPLW----YDEHFGEDLIKFLTLLMASVRNCNSVCLITM 323
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Fly
Match: CG6907 (gene:FBgn0031711 transcript:FBtr0343257)

HSP 1 Score: 53.9138 bits (128), Expect = 1.232e-7
Identity = 38/142 (26.76%), Postives = 66/142 (46.48%), Query Frame = 3 
Query:   81 LLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTAL-VIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSSYSFHNI 503
            + S+G+  LD ++ GGL   +I L+EED+   H  +L ++F+A G+ + Q+  L  +D+I  E   ++ +            +  L    +     EN    L IAWRY DL  V  + A +  G     + +  S   +N+
Sbjct:   26 ITSSGNPYLDVVIGGGLPMGSICLIEEDRFMTHAKVLAKYFLAEGVISKQEIFLGSLDDIPAEMLRRLPRPLTDQESMEQSEVQALGDAGA-----ENG---LRIAWRYNDLPLVNSEHATAKIGHHFNLMEQMDSMMLYNV 159

HSP 2 Score: 41.5874 bits (96), Expect = 7.723e-6
Identity = 17/90 (18.89%), Postives = 51/90 (56.67%), Query Frame = 2 
Query:  779 FQSNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSN 1048
            + ++++  +R + +Y ++ E+F   +        + SG +   K++++N++  +  P T   ++ + R+K + ++F LPP L +++++ +
Sbjct:  331 YDASLVPKIRQLVDYAIELESFAGSERETHPAFKEYSGLLHLHKMSAINTLA-VHMPETPDLAFKLRRKKFIIEKFHLPPELQESSAKPD 419

HSP 3 Score: 26.9498 bits (58), Expect = 7.723e-6
Identity = 21/78 (26.92%), Postives = 34/78 (43.59%), Query Frame = 3 
Query:  492 FHNINLSDNLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTI 725
            FHN      LN+     +      G+     ++ ++SLGSPLW     +E F   + +FL  L A V       ++T+
Sbjct:  250 FHNPRYKGLLNDIQQLLRNESFVAGTKNNLCRVCLTSLGSPLW----YDEHFGEDLIKFLTLLMASVRNCNSVCLITM 323
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Zebrafish
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:550331])

HSP 1 Score: 67.3958 bits (163), Expect = 1.556e-14
Identity = 65/280 (23.21%), Postives = 118/280 (42.14%), Query Frame = 3 
Query:   27 FQKMNSGKGKFLAKYKT------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQ-----VQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK------------FSSYSFHNINLSDNLNET-------LTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            FQK    K  F+   +        L+S+G  SLD ++ GGLA  T+ L+EED+ + +  +L ++F+A G+    +  L      P++ +Q     +         +  Q+ P  +PDN            + IAWRY++   V+   A S+      D +K             S Y      ++  L+         L   +  I+++G          R  L++ + SLGS LWG    C++     + +S FL+ L+ ++  S    ++T+   L++
Sbjct:   20 FQKKTRSKLVFIPGTRPSVQNGQLLVSSGVSSLDYVIGGGLAVGTLLLVEEDRYDSYSRMLLKYFLAEGIVCGHELFLASARDHPDQIMQELPSPILDDVASMKMSEGQSQPN-DPDNP---------DTMKIAWRYQNQPRVQTALASSSRFGHYYDASKTMDPELLQAAKYHSFYQLQETPVTTGLSSLPSPYLALLKSIQTLIQKEGFDGSTPQLRGRNVLRVGLHSLGSVLWGDDVCCKDNSAHCHALSTFLYALRGLLRTSLSVAMMTVPSHLIQ 289

HSP 2 Score: 31.187 bits (69), Expect = 1.556e-14
Identity = 24/107 (22.43%), Postives = 49/107 (45.79%), Query Frame = 2 
Query:  776 FFQSNVI--EIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKSGC 1090
              QS  +   I+R + +  +  E+F   +   + L+ D  G +   +I  +N +     P+T   ++ + R++   +   LPP LS+  SR ++ +      L +GC
Sbjct:  287 LIQSRAVMGRIIR-LSDTAIALESFRGSEKETNPLYKDYHGLLYVRQIPRLNCLTSEV-PDTKDLAFKLKRKQFTIERLHLPPDLSETVSRVSKAD------LAAGC 385
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Zebrafish
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:550331])

HSP 1 Score: 67.0106 bits (162), Expect = 8.842e-12
Identity = 65/280 (23.21%), Postives = 118/280 (42.14%), Query Frame = 3 
Query:   27 FQKMNSGKGKFLAKYKT------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQ-----VQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK------------FSSYSFHNINLSDNLNET-------LTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            FQK    K  F+   +        L+S+G  SLD ++ GGLA  T+ L+EED+ + +  +L ++F+A G+    +  L      P++ +Q     +         +  Q+ P  +PDN            + IAWRY++   V+   A S+      D +K             S Y      ++  L+         L   +  I+++G          R  L++ + SLGS LWG    C++     + +S FL+ L+ ++  S    ++T+   L++
Sbjct:   20 FQKKTRSKLVFIPGTRPSVQNGQLLVSSGVSSLDYVIGGGLAVGTLLLVEEDRYDSYSRMLLKYFLAEGIVCGHELFLASARDHPDQIMQELPSPILDDVASMKMSEGQSQPN-DPDNP---------DTMKIAWRYQNQPRVQTALASSSRFGHYYDASKTMDPELLQAAKYHSFYQLQETPVTTGLSSLPSPYLALLKSIQTLIQKEGFDGSTPQLRGRNVLRVGLHSLGSVLWGDDVCCKDNSAHCHALSTFLYALRGLLRTSLSVAMMTVPSHLIQ 289
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:100485395])

HSP 1 Score: 73.9442 bits (180), Expect = 2.874e-19
Identity = 69/267 (25.84%), Postives = 122/267 (45.69%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSF---------HNINLSDNLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD ++ GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P + +Q      L      QN PK          +E+    + IAWRY+++  ++    +S+      DL+K         S+ F            N++ N N+ L   ++ + ++G          +  L++ I SLGS LWG  IC +E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   29 RGKFPAIPGTRPSVHNGQLLVSTGVPSLDHIIGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVISGHEVFVASANDDPTDTLQ-DLPAPLTDEILRQNDPKST--KEAFGHVEDSQDMMKIAWRYQNMPKMEALPILSSRFGHYYDLSKTMPLEMSAKSHRFFLPHVKPPNQKENVTCNYNQLLEAIQRVVHQEGYDGSNPQKRPKTVLRVGIESLGSVLWGDDICSHERPENQHSLTRFLYALRGLLRTSLSVCVITVPTHLIQ 292

HSP 2 Score: 41.2022 bits (95), Expect = 2.874e-19
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            VR++ + V+  E+F   +  A+ L+ D  G +   +I  +NS+      +T   ++ + R+    +   LPP LSD  SRS++ + + S   L SGC
Sbjct:  300 VRNLSDTVVGLESFIGSEMEANPLYKDYHGLLHVHQIPRLNSLISDV-ADTKDLAFKLKRKIFAIERLHLPPDLSDTVSRSSKQDLAGSAKLLSSGC 395
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:100485395])

HSP 1 Score: 73.9442 bits (180), Expect = 2.875e-19
Identity = 69/267 (25.84%), Postives = 122/267 (45.69%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSF---------HNINLSDNLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD ++ GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P + +Q      L      QN PK          +E+    + IAWRY+++  ++    +S+      DL+K         S+ F            N++ N N+ L   ++ + ++G          +  L++ I SLGS LWG  IC +E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   22 RGKFPAIPGTRPSVHNGQLLVSTGVPSLDHIIGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVISGHEVFVASANDDPTDTLQ-DLPAPLTDEILRQNDPKST--KEAFGHVEDSQDMMKIAWRYQNMPKMEALPILSSRFGHYYDLSKTMPLEMSAKSHRFFLPHVKPPNQKENVTCNYNQLLEAIQRVVHQEGYDGSNPQKRPKTVLRVGIESLGSVLWGDDICSHERPENQHSLTRFLYALRGLLRTSLSVCVITVPTHLIQ 285

HSP 2 Score: 41.2022 bits (95), Expect = 2.875e-19
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            VR++ + V+  E+F   +  A+ L+ D  G +   +I  +NS+      +T   ++ + R+    +   LPP LSD  SRS++ + + S   L SGC
Sbjct:  293 VRNLSDTVVGLESFIGSEMEANPLYKDYHGLLHVHQIPRLNSLISDV-ADTKDLAFKLKRKIFAIERLHLPPDLSDTVSRSSKQDLAGSAKLLSSGC 388
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:100485395])

HSP 1 Score: 71.633 bits (174), Expect = 1.366e-18
Identity = 70/270 (25.93%), Postives = 123/270 (45.56%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSF---------HNINLSD---NLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD ++ GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P + +Q      L      QN PK          +E+    + IAWRY+++  ++    +S+      DL+K         S+ F            N+S+   N N+ L   ++ + ++G          +  L++ I SLGS LWG  IC +E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   27 RGKFPAIPGTRPSVHNGQLLVSTGVPSLDHIIGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVISGHEVFVASANDDPTDTLQ-DLPAPLTDEILRQNDPKST--KEAFGHVEDSQDMMKIAWRYQNMPKMEALPILSSRFGHYYDLSKTMPLEMSAKSHRFFLPHVKPPNQKENVSEVTCNYNQLLEAIQRVVHQEGYDGSNPQKRPKTVLRVGIESLGSVLWGDDICSHERPENQHSLTRFLYALRGLLRTSLSVCVITVPTHLIQ 293

HSP 2 Score: 41.2022 bits (95), Expect = 1.366e-18
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            VR++ + V+  E+F   +  A+ L+ D  G +   +I  +NS+      +T   ++ + R+    +   LPP LSD  SRS++ + + S   L SGC
Sbjct:  301 VRNLSDTVVGLESFIGSEMEANPLYKDYHGLLHVHQIPRLNSLISDV-ADTKDLAFKLKRKIFAIERLHLPPDLSDTVSRSSKQDLAGSAKLLSSGC 396
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:100485395])

HSP 1 Score: 72.0182 bits (175), Expect = 9.425e-14
Identity = 70/270 (25.93%), Postives = 123/270 (45.56%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSF---------HNINLSD---NLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD ++ GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P + +Q      L      QN PK          +E+    + IAWRY+++  ++    +S+      DL+K         S+ F            N+S+   N N+ L   ++ + ++G          +  L++ I SLGS LWG  IC +E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   27 RGKFPAIPGTRPSVHNGQLLVSTGVPSLDHIIGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVISGHEVFVASANDDPTDTLQ-DLPAPLTDEILRQNDPKST--KEAFGHVEDSQDMMKIAWRYQNMPKMEALPILSSRFGHYYDLSKTMPLEMSAKSHRFFLPHVKPPNQKENVSEVTCNYNQLLEAIQRVVHQEGYDGSNPQKRPKTVLRVGIESLGSVLWGDDICSHERPENQHSLTRFLYALRGLLRTSLSVCVITVPTHLIQ 293

HSP 2 Score: 24.6386 bits (52), Expect = 9.425e-14
Identity = 12/43 (27.91%), Postives = 24/43 (55.81%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSI 931
            VR++ + V+  E+F   +  A+ L+ D  G +   +I  +NS+
Sbjct:  301 VRNLSDTVVGLESFIGSEMEANPLYKDYHGLLHVHQIPRLNSL 343
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Match: ELP4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:100485395])

HSP 1 Score: 72.0182 bits (175), Expect = 3.052e-13
Identity = 70/270 (25.93%), Postives = 124/270 (45.93%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSF---------HNINLSD---NLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD ++ GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P + +Q      L      QN PK   +      +E+    + IAWRY+++  ++    +S+      DL+K         S+ F            N+S+   N N+ L   ++ + ++G          +  L++ I SLGS LWG  IC +E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   27 RGKFPAIPGTRPSVHNGQLLVSTGVPSLDHIIGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVISGHEVFVASANDDPTDTLQ-DLPAPLTDEILRQNDPKSTKE--AFGHVEDSQDMMKIAWRYQNMPKMEALPILSSRFGHYYDLSKTMPLEMSAKSHRFFLPHVKPPNQKENVSEVTCNYNQLLEAIQRVVHQEGYDGSNPQKRPKTVLRVGIESLGSVLWGDDICSHERPENQHSLTRFLYALRGLLRTSLSVCVITVPTHLIQ 293
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Mouse
Match: Elp4 (elongator acetyltransferase complex subunit 4 [Source:MGI Symbol;Acc:MGI:1925016])

HSP 1 Score: 73.559 bits (179), Expect = 5.154e-18
Identity = 71/266 (26.69%), Postives = 121/266 (45.49%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQ--------LNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLN---------------ETLTFCKKFIKEKG-----SFRKQ---LKLVISSLGSPLWGI-------CENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   + +P + +Q                P L+ DNS    +E+  S         + IAWRY+     ++ PV    F    + S ++      S  +H   L ++++                 L F +K +  +G       +KQ   L++ I +LGSPLWG        C+N  +    +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   60 LLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFMAEGIINGHTLLVASAKENPAKILQ------------ELPAPLLD-DNS-KKELEDVHSAKTPEPNVNMKIAWRYQLQPKMEVGPVSSSRFGHYYDLSKRIPWELLQSSKWHGFFLPEHISPDLKGESCFLSCGYMRLLEFIQKSVYAEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENCDNNHR----LTKFLYILRGLLRSSLSACIITMPAHLVQ 307

HSP 2 Score: 36.965 bits (84), Expect = 5.154e-18
Identity = 25/97 (25.77%), Postives = 47/97 (48.45%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSN-QNEPSRSINLKSGC 1090
            VR++ + V+  E+F   +   + L+ D  G I   KI  +N++      +    ++ + R+    +   LPP LSD   RS+ Q+  + +  L +GC
Sbjct:  315 VRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLT-CDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVGRSSKQDLAASTARLGAGC 410
[Close]
BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Match: sp|Q5XG58|ELP4_XENLA (Elongator complex protein 4 OS=Xenopus laevis OX=8355 GN=elp4 PE=2 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 3.034e-18
Identity = 76/270 (28.15%), Postives = 122/270 (45.19%), Query Frame = 3 
Query:   48 KGKFLAKYKT--------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK-------FSSYSFH---------NINLSD---NLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            +GKF A   T         L+STG  SLD +L GGLA  T+ L+EED    +  LL ++F+A G+ +  +  +      P E +Q      L      QN PK   D S       +M  + IAWRY++L  V+     S+      DL+K         S+ F+           N+S+   N N+ L   ++ + ++G          +  L+L I SLGS LW   IC  E  +  + ++RFL+ L+ ++  S    ++T+   L++
Sbjct:   27 RGKFPALPGTRPSVHNGQLLVSTGVPSLDHILGGGLAVGTLLLIEEDTYGTYSHLLLKYFLAEGVVSGHEVFVASANDDPTETLQ-DLPSPLTDEVPRQNDPKRTKDTSGPADDSQEM--MKIAWRYQNLPKVETLPISSSRFGHYYDLSKTMPPEMSAKSHRFYLPRIMSANQKQNVSEVTCNYNQLLESIQRVVHQEGYDGSNPQKRPKTILRLGIESLGSVLWADDICSQERPENQHSLTRFLYGLRGLLRTSLSVCVITVPTYLIQ 293

HSP 2 Score: 40.817 bits (94), Expect = 3.034e-18
Identity = 28/97 (28.87%), Postives = 50/97 (51.55%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            +RS+ + V+  E+F   +  A+ L+ D  G +   +I  +NS+      +T   ++ + R+    +   LPP LSD  SRS++ + + S   L SGC
Sbjct:  301 LRSLSDTVVGLESFIGSEMEANPLYKDYHGLLHVHQIPRLNSLISDGS-DTKDLAFKLKRKIFAIERLHLPPDLSDTVSRSSKQDLAGSAKLLSSGC 396
[Close]
BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Match: sp|Q96EB1|ELP4_HUMAN (Elongator complex protein 4 OS=Homo sapiens OX=9606 GN=ELP4 PE=1 SV=2)

HSP 1 Score: 77.7962 bits (190), Expect = 1.857e-17
Identity = 67/263 (25.48%), Postives = 114/263 (43.35%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMS---------QLNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETL---------------TFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   +  P   +Q               LP    D+      + D+          ++ IAWRY+     ++ PV    F    + S ++      + ++H   L + ++ TL                F +  I E+G          R  L++ I +LGSPLWG    C       + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVNGHTLLVASAKEDPANILQ--------------ELPAPLLDDKCKKEFDEDVYNHKTPESNIKMKIAWRYQLLPKMEIGPVSSSRFGHYYDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYEEGFDGSNPQKKQRNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQ 309

HSP 2 Score: 33.113 bits (74), Expect = 1.857e-17
Identity = 25/101 (24.75%), Postives = 48/101 (47.52%), Query Frame = 2 
Query:  791 VIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSIN-LKSGC 1090
            +I  V ++ + V+  E+F   +   + L+ D  G I   +I  +N++      +    ++ + R+    +   LPP LSD  SRS++ + + S   L  GC
Sbjct:  313 IIARVTTLSDVVVGLESFIGSERETNPLYKDYHGLIHIRQIPRLNNL-ICDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVSRSSKMDLAESAKRLGPGC 412
[Close]
BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Match: sp|Q9ER73|ELP4_MOUSE (Elongator complex protein 4 OS=Mus musculus OX=10090 GN=Elp4 PE=1 SV=2)

HSP 1 Score: 73.559 bits (179), Expect = 3.062e-17
Identity = 71/266 (26.69%), Postives = 121/266 (45.49%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQ--------LNIAWRYR-----DLAPVKDD-FAMSNNGSSKVDLTKFSSYSFHNINLSDNLN---------------ETLTFCKKFIKEKG-----SFRKQ---LKLVISSLGSPLWGI-------CENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ N     +   + +P + +Q                P L+ DNS    +E+  S         + IAWRY+     ++ PV    F    + S ++      S  +H   L ++++                 L F +K +  +G       +KQ   L++ I +LGSPLWG        C+N  +    +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   60 LLVSTGLPALDQLLGGGLAVGTLLLIEEDKYNIYSPLLFKYFMAEGIINGHTLLVASAKENPAKILQ------------ELPAPLLD-DNS-KKELEDVHSAKTPEPNVNMKIAWRYQLQPKMEVGPVSSSRFGHYYDLSKRIPWELLQSSKWHGFFLPEHISPDLKGESCFLSCGYMRLLEFIQKSVYAEGFDGANPQKKQKNILRIGIQNLGSPLWGDDICCKENCDNNHR----LTKFLYILRGLLRSSLSACIITMPAHLVQ 307

HSP 2 Score: 36.965 bits (84), Expect = 3.062e-17
Identity = 25/97 (25.77%), Postives = 47/97 (48.45%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSN-QNEPSRSINLKSGC 1090
            VR++ + V+  E+F   +   + L+ D  G I   KI  +N++      +    ++ + R+    +   LPP LSD   RS+ Q+  + +  L +GC
Sbjct:  315 VRNLSDTVVGLESFIGSERETNPLYKDYHGLIHIRKIPRLNNLT-CDESDVKDLAFKLKRKLFTIERLHLPPDLSDTVGRSSKQDLAASTARLGAGC 410
[Close]
BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Match: sp|Q2TBH6|ELP4_BOVIN (Elongator complex protein 4 OS=Bos taurus OX=9913 GN=ELP4 PE=2 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 8.389e-17
Identity = 67/254 (26.38%), Postives = 122/254 (48.03%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKF---------------------SSYSFHNINLSDNLNETLTFCKKFIKEKG-----SFRKQ---LKLVISSLGSPLWG--ICENEE-KFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+STG  +LD LL GGLA  T+ L+EEDK NI+  LL ++F+A G+ +     +   +  P + +Q      L       +  K   ++    ++E D+ ++ IAWRY+ L  ++     S+      D++K                      S+++  + +L+    + L F +  I ++G       +KQ   L++ I +LGSPLWG  IC  E     + +++FL+ L+ ++  S  + I+T+   L++
Sbjct:   61 LLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLAEGIVSGHALLVASAKEDPADILQ-----KLPAPLIDDSYKKECDEDVCSHKMEPDI-KMKIAWRYQLLPKMEAGPVSSSRFGHYYDISKRIPQELIETSKWHGFFLPEKISSAFNVESCSLTPGYMKLLQFIQNIIYKEGFDGSNPQKKQKNILRIGIQNLGSPLWGDDICCTENCDTSHSLTKFLYILRGLLRTSLSACIITMPTHLIQ 308

HSP 2 Score: 34.2686 bits (77), Expect = 8.389e-17
Identity = 26/102 (25.49%), Postives = 50/102 (49.02%), Query Frame = 2 
Query:  791 VIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFR-PNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKS-GC 1090
            VI  V ++ + V+  E+F   +   + L+ D  G I   +I  +N++  I+   +    ++ + ++    +   LPP LSD  SRS++ + + S  L   GC
Sbjct:  312 VIARVTNLSDTVVGLESFIGSEKETNPLYKDYHGLIHIRQIPRLNNL--IYDISDVKDLAFKLKKKLFTIERLHLPPDLSDTVSRSSKQDLAESTKLLGPGC 411
[Close]
BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Match: sp|Q566Y1|ELP4_DANRE (Elongator complex protein 4 OS=Danio rerio OX=7955 GN=elp4 PE=2 SV=2)

HSP 1 Score: 67.3958 bits (163), Expect = 9.417e-14
Identity = 65/280 (23.21%), Postives = 118/280 (42.14%), Query Frame = 3 
Query:   27 FQKMNSGKGKFLAKYKT------FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQ-----VQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK------------FSSYSFHNINLSDNLNET-------LTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            FQK    K  F+   +        L+S+G  SLD ++ GGLA  T+ L+EED+ + +  +L ++F+A G+    +  L      P++ +Q     +         +  Q+ P  +PDN            + IAWRY++   V+   A S+      D +K             S Y      ++  L+         L   +  I+++G          R  L++ + SLGS LWG    C++     + +S FL+ L+ ++  S    ++T+   L++
Sbjct:   20 FQKKTRSKLVFIPGTRPSVQNGQLLVSSGVSSLDYVIGGGLAVGTLLLVEEDRYDSYSRMLLKYFLAEGIVCGHELFLASARDHPDQIMQELPSPILDDVASMKMSEGQSQPN-DPDNP---------DTMKIAWRYQNQPRVQTALASSSRFGHYYDASKTMDPELLQAAKYHSFYQLQETPVTTGLSSLPSPYLALLKSIQTLIQKEGFDGSTPQLRGRNVLRVGLHSLGSVLWGDDVCCKDNSAHCHALSTFLYALRGLLRTSLSVAMMTVPSHLIQ 289

HSP 2 Score: 31.187 bits (69), Expect = 9.417e-14
Identity = 24/107 (22.43%), Postives = 49/107 (45.79%), Query Frame = 2 
Query:  776 FFQSNVI--EIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKSGC 1090
              QS  +   I+R + +  +  E+F   +   + L+ D  G +   +I  +N +     P+T   ++ + R++   +   LPP LS+  SR ++ +      L +GC
Sbjct:  287 LIQSRAVMGRIIR-LSDTAIALESFRGSEKETNPLYKDYHGLLYVRQIPRLNCLTSEV-PDTKDLAFKLKRKQFTIERLHLPPDLSETVSRVSKAD------LAAGC 385
[Close]
BLAST of Elongator complex protein 4 vs. TrEMBL
Match: G4VSM8 (Uncharacterized protein OS=Schistosoma mansoni OX=6183 GN=Smp_015800 PE=4 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 1.083e-20
Identity = 68/250 (27.20%), Postives = 113/250 (45.20%), Query Frame = 3 
Query:   36 MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSL-VPRIENDMSQLNIAWRYRDLAPVKD------------DFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKGSFRKQLK-------LVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTI 725
            MN  K  F  K  TFL+STG  SLD LL GG+ + +I L+E D    +  LL   F+A G+ +       I   + E F  +              L KL PD+ +    I+ ++S L IAWRY+++  VK+            +  M  N ++++     S++ F      D+     T     I++   FR   K       +V++S GSP+WG C++ ++F   +  F   L+ ++     +V +T+
Sbjct:    1 MNGVKRSF--KLSTFLISTGIPSLDELLGGGVTSGSIILIEPDFHQTYAKLLLNLFVAEGILSGHS----IFYGAKETFDSL--------------LSKL-PDHMISTNEIKEEISDLKIAWRYQNVPNVKNVNSSVSSLGHHFNVTMPMNATARISEKNVSTFYFQ----PDSKKTLHTNLSSLIQKLTIFRSNTKVSSVIQRIVVNSCGSPMWGYCKDTQQFYRNMLSFFATLRLLIQNGHCTVFITL 225

HSP 2 Score: 55.0694 bits (131), Expect = 1.083e-20
Identity = 29/84 (34.52%), Postives = 47/84 (55.95%), Query Frame = 2 
Query:  815 CNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKI---ASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNE 1057
            C+YV + +   D +  A+ ++++  G +  I I    S N++EP FR  T  W + I R +++ + F LPP LSD  +RSN  E
Sbjct:  242 CDYVFRVQGLRD-QIQANPVYSEYDGLLTVIHIPWLISGNTLEPAFRSATLEWCFKIKRHQLVVQHFHLPPSLSDTVNRSNAQE 324
[Close]
BLAST of Elongator complex protein 4 vs. TrEMBL
Match: C1LHD9 (Elongator complex protein 4 (PAX6 neighbor gene protein) OS=Schistosoma japonicum OX=6182 PE=2 SV=1)

HSP 1 Score: 72.4034 bits (176), Expect = 5.169e-20
Identity = 65/258 (25.19%), Postives = 112/258 (43.41%), Query Frame = 3 
Query:   36 MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDN-SLVPRIENDMSQLNIAWRYRDLAPVKD------------DFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKGSFRKQ---LKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLEVIQFLR 761
            MN  K  F  K  TFL+STG  S D LL GG+A+ +I L+E D    +   L   F+A G+ +         E       ++                   PDN + V  +  + + L IAWRY++++  K+            +  +  + ++++     S+ SF   +        ++  +KFIK + + +      ++VI+S GSPLWG C++ ++F   +  F   L  ++  S  +V VT+    L    F R
Sbjct:    1 MNGVKRSF--KLSTFLISTGIPSFDELLGGGVASGSIILVEPDFHQTYAKQLLNLFVAEGILSGHSVFYGATETLDRLLRKL-------------------PDNITPVNEVNEETTDLKIAWRYQNVSNTKNLNHFTSNLGHHFNMTIPMDAAAQISEKNVSTSSFQPDSKKTLQTNLVSLIQKFIKFRSNTKVSSGIQRIVINSCGSPLWGNCKDTQQFYRSMLNFFATLHLLIQNSHSTVFVTLPAAKLPPGLFTR 237

HSP 2 Score: 55.0694 bits (131), Expect = 5.169e-20
Identity = 25/88 (28.41%), Postives = 49/88 (55.68%), Query Frame = 2 
Query:  803 VRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKI---ASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNE 1057
            +   C+Y+ + +   D +  A+ ++++  G +   +I      N++EP FR  T  W++ + R +++ +   LPPCLSD  +RSN +E
Sbjct:  238 ISHYCDYIFQVQGLSD-QIQANPVYSEYDGLLTVYRIPWLIGGNTLEPAFRSTTLEWAFKMKRHQLIVQHLHLPPCLSDTVNRSNTSE 324
[Close]
BLAST of Elongator complex protein 4 vs. TrEMBL
Match: Q5DBL9 (Elongator complex protein OS=Schistosoma japonicum OX=6182 GN=EWB00_005667 PE=2 SV=1)

HSP 1 Score: 72.0182 bits (175), Expect = 6.507e-20
Identity = 64/258 (24.81%), Postives = 112/258 (43.41%), Query Frame = 3 
Query:   36 MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDN-SLVPRIENDMSQLNIAWRYRDLAPVKD------------DFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKGSFRKQ---LKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLEVIQFLR 761
            MN  K  F  K  TFL+STG  S D LL GG+A+ +I L+E D    +   L   F+A G+ +         E       ++                   PDN + V  +  + + L IAWRY++++  K+            +  +  + ++++     S+ SF   +        ++  +KFIK + + +      ++VI+S GSP+WG C++ ++F   +  F   L  ++  S  +V VT+    L    F R
Sbjct:    1 MNGVKRSF--KLSTFLISTGIPSFDELLGGGVASGSIILVEPDFHQTYAKQLLNLFVAEGILSGHSVFYGATETLDRLLRKL-------------------PDNITPVDEVNEETTDLKIAWRYQNVSNTKNLNHFTSNLGHHFNMTIPMDAAAQISEKNVSTSSFQPDSKKTLQTNLVSLIQKFIKFRSNTKVSSGIQRIVINSCGSPMWGNCKDTQQFYRSMLNFFATLHLLIQNSHSTVFVTLPAAKLPPGLFTR 237

HSP 2 Score: 55.0694 bits (131), Expect = 6.507e-20
Identity = 25/84 (29.76%), Postives = 48/84 (57.14%), Query Frame = 2 
Query:  815 CNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKI---ASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNE 1057
            C+Y+ + +   D +  A+ ++++  G +   +I      N++EP FR  T  W++ + R +++ +   LPPCLSD  +RSN +E
Sbjct:  242 CDYIFQVQGLSD-QIQANPVYSEYDGLLTVYRIPWLIGGNTLEPAFRSTTLEWAFKMKRHQLIVQHLHLPPCLSDTVNRSNTSE 324
[Close]
BLAST of Elongator complex protein 4 vs. TrEMBL
Match: A0A1B0DFP0 (Uncharacterized protein OS=Phlebotomus papatasi OX=29031 PE=4 SV=1)

HSP 1 Score: 82.8037 bits (203), Expect = 7.176e-20
Identity = 72/242 (29.75%), Postives = 113/242 (46.69%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVP----RIENDMSQLNIAWRYRDLAPV------KDD--FAMSNNGSS----KVDLTKFSSYSFHNINLSDNLNETLT-FCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLEVIQ 752
             L+STG+ S+D ++ GG+   TI L+EEDK N +  +LC++F+A G+       L   E + ++F++                 KL      VP     + N   ++ IAWRY DL  V      K D  F +S N         D+T   S       L   L E L+  C K  +E  S +K L++ ++SLGSPLW     +E F   + RFL  L++++  ST   +++I   L   ++
Sbjct:   25 LLVSTGNSSIDHIIGGGMPLGTILLIEEDKYNSYAKVLCRYFLAEGVYRKHSVFLATKEDNADDFVR-----------------KLPQAIEEVPEKRTELRNVEEEMRIAWRYNDLPKVSLEQGSKRDYHFDLSRNVPQGDIEACDITSIGSDENFG-QLQKALKEKLSDKCFKLSEE--SEKKLLRICLNSLGSPLWW---TKEDFEGKLVRFLVILRSLMRNSTAVCMISIPTHLFHCLE 243

HSP 2 Score: 44.2838 bits (103), Expect = 7.176e-20
Identity = 19/84 (22.62%), Postives = 48/84 (57.14%), Query Frame = 2 
Query:  779 FQSNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSD 1030
             +  ++  +R++ +Y ++ E+F   +A  + ++ +  G +   +I +VN++ P FRP T   ++   R+K + ++  LPP +++
Sbjct:  242 LEPKLLARLRNLVDYAIEIESFSGAEAETNAMYREYHGLVHIHRITAVNTLAP-FRPETFDLAFKQRRKKFVVEKLHLPPDIAE 324
[Close]
BLAST of Elongator complex protein 4 vs. TrEMBL
Match: A0A0J7L0L6 (Elongator complex protein 4 OS=Lasius niger OX=67767 GN=RF55_3622 PE=4 SV=1)

HSP 1 Score: 92.0485 bits (227), Expect = 1.103e-19
Identity = 67/245 (27.35%), Postives = 115/245 (46.94%), Query Frame = 3 
Query:   66 KYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDM-SQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK---------------------FSSYSFHNINLSD---NLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTI 725
            K    L+STG  SLD ++ GGL   +I L+EEDK  ++  +  ++F+A G+  +Q   +   ++ P +F+                LP +  D+ L  + E+D+  Q+ IAWRY+++  +      S       DLTK                     + + +F N   +D    + ETL   + FI E    +K L++VI SLGS LW + + EE     + +FL+C +A++  S    ++T+
Sbjct:   30 KNAQLLISTGIPSLDNIIGGGLPIGSILLIEEDKYGLYAKIALKYFMAEGVVTSQPLLVASQDVQPSQFV--------------SELPAVIKDSDLYTKTEDDVDEQMKIAWRYQNMKVIDSSPTGSQIFGHYYDLTKPMQQDLLEHAEIKQWDENNLQWQNNTFENTAYTDLLLTVQETLRNGQYFISETTDKKKILRIVIHSLGSRLW-LSDTEESSNRDLLKFLYCFRALLRNSYAVGVITV 259

HSP 2 Score: 34.2686 bits (77), Expect = 1.103e-19
Identity = 23/92 (25.00%), Postives = 45/92 (48.91%), Query Frame = 2 
Query:  791 VIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEP---IFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNE 1057
            VIE +  M +  ++ E+F       + L  D  G +   K++++N++ P    FR      ++ + R+K + +   LPP   D T++  Q+E
Sbjct:  270 VIERIEHMSDIAVRLESFAGSAKETNPLFKDYHGLLHIEKLSALNTLAPRCAEFRD----LAFKLRRKKFVIEVLHLPPEFED-TAQREQDE 356
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Cavefish
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:103037255])

HSP 1 Score: 61.2326 bits (147), Expect = 4.287e-10
Identity = 58/245 (23.67%), Postives = 103/245 (42.04%), Query Frame = 3 
Query:   87 STGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVK----DDFAMSNNGSSKVDLTKFSSYSFHNI----NLSDNLNETLTFCKKFIK---------------EKGSFRKQLKLVISSLGSPLWG--ICENEEK-FLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
            S+G+  LD  L GGL   ++ L+EED+ + +  LL Q+F+A G+ +     L      P++ IQ     +L+      +      D          +  + IAWRY++L   +      F    + S ++D     +   H        +D    +L      +K                +G  R  L+L + SLGS LWG  +C +E     + ++ FL+ L+A++  S    +VT+   L++
Sbjct:   36 SSGAPGLDRALGGGLVVGSLLLIEEDQNDSYSRLLLQYFLAEGVVSGHQLYLASARDDPDDMIQDLPCPILDDVGLSSSSSAPPADT-------QTLDTMKIAWRYQNLPQTELASSSRFGHCYDLSKRMDTRMLQAVQRHTFYPPQEKTDEQTSSLGPYAGLLKSIQTVIHREGFDGSGSEGKVRNVLRLGLHSLGSALWGDDVCFSESPDSGHALTTFLYALRALLRSSLSVAMVTVPAHLIQ 273
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Nematostella
Match: EDO39802 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S8W5])

HSP 1 Score: 79.7221 bits (195), Expect = 5.152e-17
Identity = 66/245 (26.94%), Postives = 106/245 (43.27%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGS-------------SKVDLTKFSSYSFHNINLSDNLNETL------TFCKKFIKEKGSFRKQ---LKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLEV 746
             L+STG  SLD ++ GG+A  T+ L+EED    +   L ++F+A G+ +     L   E+ P   +   K     +     + P L+       R E  M    IAWRY+ L  V+   A SN                 ++ +T F + S  +  + + L E L      T C+         ++Q   L+L +  LGS LWG   +   F   + RFL+CL+A +  S    +VT+   + +V
Sbjct:   29 LLVSTGIPSLDSVIGGGIAVGTVLLVEEDIYGSYARQLLKYFLAEGIVSGHSLFLASAELEPSAIL---KDLPYPMNEEDDSEPGLSTPG----RQEESM---KIAWRYQQLPKVQSSLACSNFSHYFDLTRVMKEPRVHRLPITTFDATSEWSEGIQNPLYEKLISSLKQTICQGGYSTTHKQQQQKSILRLALHGLGSQLWGEACSATDFTTGLPRFLYCLRAQLRSSFAVCMVTMPTHVFQV 263
[Close]
BLAST of Elongator complex protein 4 vs. Ensembl Medaka
Match: elp4 (elongator acetyltransferase complex subunit 4 [Source:NCBI gene;Acc:101163158])

HSP 1 Score: 77.7962 bits (190), Expect = 1.972e-15
Identity = 65/253 (25.69%), Postives = 118/253 (46.64%), Query Frame = 3 
Query:   78 FLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTK------------FSSYSFHNINLS--------DNLNETLTFCKKFIKEKG--------SFRKQLKLVISSLGSPLWG---ICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE 743
             L+S+G  SLD LL GGLA  T+ L+EED+ +    ++ ++F+A G+    +  +   +  P++ +  Q+L    L +   + P   P  S  P  ++ +  + IAWRY++L  V+   A S+      D++K               Y   +  LS        ++ +  L   +  I+ +G          R  L++ + SLGS LWG    C N  K ++ ++ FL+ L+A++  S    +VT+   L++
Sbjct:   46 LLVSSGVTSLDYLLGGGLAVGTVLLIEEDRYDSFSRMIFKYFLAEGVVCRHELFVAAAQDDPDDIL--QELPAPILDDVAIHRPGEQPRMSCEP--QDTLDAMKIAWRYQNLPKVQSALASSSRFGHYYDVSKTMEPEIRQAAKWHRFYHPEHPPLSSGTHSPKLESYSALLKSLRDVIQREGFDLTAPLPKSRNILRVGLHSLGSALWGDDLCCYNNPKNVHALTSFLYGLRALLRTSLSVAVVTVPSHLIQ 294
[Close]
BLAST of Elongator complex protein 4 vs. Planmine SMEST
Match: SMESG000053286.1 (SMESG000053286.1)

HSP 1 Score: 432.95 bits (1112), Expect = 1.508e-152
Identity = 224/244 (91.80%), Postives = 226/244 (92.62%), Query Frame = 3 
Query:   36 MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKXXXXXXXXXXXXXPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE--VIQFLR 761
            MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQ              NLPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKG FRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLE  VI+ +R
Sbjct:    1 MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCSLLCQHFIAHGLSNNQDTALVIDEISPEEFIQ--------------NLPKLNPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSSYSFHNINLSDNLNETLTFCKKFIKEKGLFRKQLKLVISSLGSPLWGICENEEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLESNVIEIVR 230

HSP 2 Score: 216.468 bits (550), Expect = 1.069e-67
Identity = 102/105 (97.14%), Postives = 103/105 (98.10%), Query Frame = 2 
Query:  776 FFQSNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKSGC 1090
              +SNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKSGC
Sbjct:  220 LLESNVIEIVRSMCNYVLKFEAFDDPKAVADQLHNDVSGQIRPIKIASVNSIEPIFRPNTSIWSYHIHRRKMLFKEFCLPPCLSDNTSRSNQNEPSRSINLKSGC 324
The following BLAST results are available for this feature:
BLAST of Elongator complex protein 4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ELP44.280e-1825.48elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP49.875e-1825.38elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP42.453e-1525.48elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP42.961e-1525.48elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP42.989e-1525.48elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
elpc-42.558e-626.01Putative elongator complex protein 4 [Source:UniP... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
CG69071.232e-726.76gene:FBgn0031711 transcript:FBtr0079096[more]
CG69071.232e-726.76gene:FBgn0031711 transcript:FBtr0343257[more]
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BLAST of Elongator complex protein 4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
elp41.556e-1423.21elongator acetyltransferase complex subunit 4 [Sou... [more]
elp48.842e-1223.21elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ELP42.874e-1925.84elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP42.875e-1925.84elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP41.366e-1825.93elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP49.425e-1425.93elongator acetyltransferase complex subunit 4 [Sou... [more]
ELP43.052e-1325.93elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Elp45.154e-1826.69elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q5XG58|ELP4_XENLA3.034e-1828.15Elongator complex protein 4 OS=Xenopus laevis OX=8... [more]
sp|Q96EB1|ELP4_HUMAN1.857e-1725.48Elongator complex protein 4 OS=Homo sapiens OX=960... [more]
sp|Q9ER73|ELP4_MOUSE3.062e-1726.69Elongator complex protein 4 OS=Mus musculus OX=100... [more]
sp|Q2TBH6|ELP4_BOVIN8.389e-1726.38Elongator complex protein 4 OS=Bos taurus OX=9913 ... [more]
sp|Q566Y1|ELP4_DANRE9.417e-1423.21Elongator complex protein 4 OS=Danio rerio OX=7955... [more]
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BLAST of Elongator complex protein 4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
G4VSM81.083e-2027.20Uncharacterized protein OS=Schistosoma mansoni OX=... [more]
C1LHD95.169e-2025.19Elongator complex protein 4 (PAX6 neighbor gene pr... [more]
Q5DBL96.507e-2024.81Elongator complex protein OS=Schistosoma japonicum... [more]
A0A1B0DFP07.176e-2029.75Uncharacterized protein OS=Phlebotomus papatasi OX... [more]
A0A0J7L0L61.103e-1927.35Elongator complex protein 4 OS=Lasius niger OX=677... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
elp44.287e-1023.67elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Elongator complex protein 4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Elongator complex protein 4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO398025.152e-1726.94Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Elongator complex protein 4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
elp41.972e-1525.69elongator acetyltransferase complex subunit 4 [Sou... [more]
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BLAST of Elongator complex protein 4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000053286.11.508e-15291.80SMESG000053286.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018912 ID=SMED30018912|Name=Elongator complex protein 4|organism=Schmidtea mediterranea sexual|type=transcript|length=1092bp
ATTTGTTTTAATATTCATTATTAAAATTTCAAAAAATGAATTCTGGCAAA
GGGAAATTTTTAGCTAAATACAAGACCTTTCTTTTATCCACTGGATCTTT
ATCATTAGATTGCCTTTTAAATGGTGGTCTTGCAACAAACACAATTACAT
TATTAGAAGAAGACAAACTTAATATTCATTGTTCATTATTGTGCCAGCAT
TTTATTGCCCATGGTTTATCAAATAATCAGGATACTGCTCTAGTTATTGA
TGAAATATCACCAGAAGAATTTATACAAGTTCAAAAGCTATTTCTTTTAA
ATCTTTATAATTTTCTACAGAATTTACCTAAACTTAATCCAGATAACTCC
TTAGTTCCTAGAATAGAAAATGATATGTCACAATTAAATATAGCATGGAG
ATATAGAGATTTGGCACCTGTGAAAGATGATTTTGCAATGTCTAATAATG
GTTCATCAAAAGTTGATTTAACTAAATTTAGTTCTTATTCATTTCATAAC
ATAAATTTATCGGATAATTTGAATGAAACTTTAACTTTCTGCAAGAAATT
CATTAAAGAAAAGGGTTCATTTAGAAAACAACTGAAATTAGTAATTTCTT
CACTCGGTTCGCCGCTTTGGGGAATTTGTGAAAACGAAGAGAAATTTCTC
AATTTAATCTCTCGATTTTTGTTCTGTCTGAAAGCGATCGTCAGTGAATC
GACAATTTCTGTTATCGTTACAATCAATCCAGATTTATTAGAAGTAATAC
AATTCCTGAGAAAAGATTTCAATAATTTTTCCAGTCGAATGTCATCGAAA
TCGTTCGATCGATGTGTAATTACGTACTGAAATTCGAGGCATTCGACGAT
CCAAAAGCCGTAGCTGATCAGTTGCACAATGACGTCAGCGGGCAAATCCG
ACCAATCAAAATCGCAAGCGTCAATTCAATCGAACCGATATTCAGGCCAA
ACACGAGCATTTGGAGCTATCACATACACAGGAGGAAAATGCTGTTTAAA
GAATTCTGTTTACCTCCGTGTTTGTCCGATAATACGAGCCGGTCCAATCA
GAACGAGCCGTCAAGGTCAATAAATCTCAAATCTGGCTGTGG
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protein sequence of SMED30018912-orf-1

>SMED30018912-orf-1 ID=SMED30018912-orf-1|Name=SMED30018912-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=265bp
MNSGKGKFLAKYKTFLLSTGSLSLDCLLNGGLATNTITLLEEDKLNIHCS
LLCQHFIAHGLSNNQDTALVIDEISPEEFIQVQKLFLLNLYNFLQNLPKL
NPDNSLVPRIENDMSQLNIAWRYRDLAPVKDDFAMSNNGSSKVDLTKFSS
YSFHNINLSDNLNETLTFCKKFIKEKGSFRKQLKLVISSLGSPLWGICEN
EEKFLNLISRFLFCLKAIVSESTISVIVTINPDLLEVIQFLRKDFNNFSS
RMSSKSFDRCVITY*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: biological process
TermDefinition
GO:0002098tRNA wobble uridine modification
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR008728Elongator_complex_protein_4
IPR027417P-loop_NTPase
Vocabulary: cellular component
TermDefinition
GO:0033588Elongator holoenzyme complex
GO:0016020membrane
GO:0016021integral component of membrane
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR008728Elongator complex protein 4PFAMPF05625PAXNEBcoord: 15..240
e-value: 1.8E-24
score: 86.6
IPR008728Elongator complex protein 4PANTHERPTHR12896PAX6 NEIGHBOR PROTEIN PAXNEBcoord: 14..236