Dynein intermediate chain 2, ciliary

Query:   44 KPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSN------LSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQT-------STTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            +P ++  S     +++D+D  T+   + E  D +   +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YKP+ +++   +H++   NL+ KDS E          ++V       SV +  E       E  ++  +   SQT       +    +E           K +NQF +  RA+QT NNP++ +  Q+E PPR  FS   +Q  IYD+Y  + ++Q +  +        ++K      ++++ + E    D+  +    KI+ERM+N NT+D+IAQDF YY+D ADE+R D  GTLLPLWKF  DK ++L VT++ W+  Y+DLF V +G Y+ +  + +G +  YSLKNPS+PEY   + S V+ +D++++   L+  G  DG V I +L +K  S P     S+  S KH DP WQVKW   + D  + F+S+SSDGRI  W++ K +L   D++ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  + W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  ++D +IN+ E +  Q V + K++  LT + F+  +PII++GD R +
Sbjct:   12 QPHKQSISIGRGTRKRDEDSGTE---VGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAVSYQGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSM-ESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYR-DQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMK-QSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNL-KKPHSQP--SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNR--LTHVQFNLIHPIIIVGDDRGH 656          

Query:   44 KPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            +P ++  S     +++D+D  T+   + E  D +   +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YKP+ +++   +H++   NL+           Y+D + A S  SV    +  + +L  + +   +      +     +  +    +E           K +NQF +  RA+QT NNP++ +  Q+E PPR  FS   +Q  IYD+Y  + ++Q +  +        ++K      ++++ + E    D+  +    KI+ERM+N NT+D+IAQDF YY+D ADE+R D  GTLLPLWKF  DK ++L VT++ W+  Y+DLF V +G Y+ +  + +G +  YSLKNPS+PEY   + S V+ +D++++   L+  G  DG V I +L +K  S P     S+  S KH DP WQVKW   + D  + F+S+SSDGRI  W++ K +L   D++ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  + W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  ++D +IN+ E +  Q V + K++  LT + F+  +PII++GD R +
Sbjct:   12 QPHKQSISIGRGTRKRDEDSGTE---VGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISE--TGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSM-ESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYR-DQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMK-QSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNL-KKPHSQP--SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNR--LTHVQFNLIHPIIIVGDDRGH 652          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMA-------FYSISSDGRICEWSVNKYELNCQDIVALRQI----NLPIDMETVADRFLES----GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNP-LFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS D T+ L V+S+ W+    DL  V +G +    F+EQ  G  C +S+KNP +PE    +   V A+D +I    L+  G  +G + I ++  +S+SN V  L S+   +KH  P WQ++W  IE+D             SIS+DGRI +W + K  L+C D++ L++     N     +   D  L S    G C A HPK  + +L GT++G+I+       +   N  Y  T+    HK  +Y++ W+ +  D+F SCSADW + IW      P L        V  +AW+P SS + AA   +R V ++D  I+ L+PL   +V ++   +  T I+F+     +L+GDS     +Y
Sbjct:  475 LWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF---GFKEQKRGLACCWSIKNPMWPERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNV--RSNSN-VPVLDSSESPQKHLGPVWQLQW--IEQDRGTTGDGKREILVSISADGRISKWVIRK-GLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFHPKDTNIYLAGTEEGHIH-----KCSCSYNEQYLDTYRG--HKGPVYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENR-VEIWDLHISTLDPL---IVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVY 819          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMA-------FYSISSDGRICEWSVNKYELNCQDIVALRQI----NLPIDMETVADRFLES----GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNP-LFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS D T+ L V+S+ W+    DL  V +G +    F+EQ  G  C +S+KNP +PE    +   V A+D +I    L+  G  +G + I ++  +S+SN V  L S+   +KH  P WQ++W  IE+D             SIS+DGRI +W + K  L+C D++ L++     N     +   D  L S    G C A HPK                                          +Y++ W+ +  D+F SCSADW + IW      P L        V  +AW+P SS + AA   +R V ++D  I+ L+PL   +V ++   +  T I+F+     +L+GDS     +Y
Sbjct:  241 LWSFSCDLTKGLNVSSLAWNKTNPDLLAVGYGHF---GFKEQKRGLACCWSIKNPMWPERIYQSPYGVTAVDFSIGAPNLLAVGYHNGTIAIYNV--RSNSN-VPVLDSSESPQKHLGPVWQLQW--IEQDRGTTGDGKREILVSISADGRISKWVIRK-GLDCYDLMRLKRTTAASNKKGGEKEKKDEALISRQAPGMCFAFHPKGP----------------------------------------VYKVTWNPFCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENR-VEIWDLHISTLDPL---IVNTANPGIKFTTILFAKQTDCLLVGDSDGQVSVY 552          

Query:   86 RKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQ 886
            ++D+D  T+   + E  D +   +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YKP+ +++   +H++   NL+           Y+D + A S  SV    +  + +L  + +   +      +     +  +    +E           K +NQF +  RA+QT NNP++ +  Q+E PPR  FS   +Q  IYD+Y  + ++Q +  +        ++K      ++++ + E    D+  +    KI+ERM+N NT+D+IAQ
Sbjct:   15 KQDEDSGTE---VGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISE--TGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSM-ESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ 289          

Query:  836 KILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKT--RKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSY-PEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADR--FLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWH--------PDIFASCSADWTIGIWNCRQSN--------PLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIYFSKITFLHEYIVKQYLFKIFQARI 2065
            K++ R +N    +EI    +Y +DP +  +  +   LL L +   D+T   K  VT + +S  Y DL  VS+G  +I + E  G I  ++ K+     E+ ++ +S + ++        L+ AG   G + +      S   P+ R      +  +   C  V    +   N   F S+S DGRIC W+V+              +  P+D + +  +     S T ++    +  TF+VGT  G I       +  ++ +D ++   +  +K     L    +H          +F S S DWT+ +W+ + +N        P  VLD       +AW+P    V A++  D  + V++ + +   P+     G+    V + ++++S +   + +GD      +Y  + +    Y++K   +  F AR+
Sbjct:  238 KVISRALN----EEIDICINYTKDPYE--KAIASDDLLHLAQVYQDETWTAKRLVTGMAFSEHYPDLLAVSYGPCDIPN-EPPGVIVVWNTKSKRMTAEFIVYCQSEIQSVAFARFHAHLLLAGCESGQICVWDNRLTSRKLPINRSPLTTQAHTYTVSCLAV----VGTKNAHNFVSLSRDGRICSWNVD-------------NLTQPVDGKELMTKEGKAASATRMSFPIGEMQTFVVGTDTGEIL------AASRNGADPAVIKTDVCYKGHSGTLTGIEFHRASGVVDFSHLFISSSHDWTVKLWSTKDANLKFSFESHPDLVLD-------VAWSPVHPAVFASIDADGNIFVWNLNEDVEGPVARLRAGAEGESVYMNRLIWSPDGKHVFVGDDEGRVHMYDVRESL---YVLKSEEWNRF-ARV 627          

Query: 1487 ESGTCIALHPKKYHTFLVGTQDGNI-YYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFA-VTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILI--GDSRFYYFIYFSKI 2005
            + G  ++ +P K    L  + D  + ++ +  N N+         F    H+ ++  + W   H  +F S   D  + IW+ R S P   +D   A V  +A+ PYS  +LA  + D+ V ++D     L  L  ++     H+  + Q+ +S +   IL   G  +  +    SKI
Sbjct:  173 KEGYGLSWNPNKEGLILSASDDQTVCHWDINANQNVAGELQAKDVFKG--HESVVEDVAWHVLHDGVFGSVGDDKKLLIWDVRTSTPGHCIDAHSAEVNCLAFNPYSEFILATGSADKTVALWD-----LRNLRMKLHSFESHRDEIFQVQWSPHNETILASSGTDKRLHVWDLSKI 342          

Query:  551 NQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPI--------LPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESG-TCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            NQF YC R   T  NP +   TQ+  PPR  F  N+ Q VIYDSY              + NF  SQK     ++R     EK F D + I        L   +ILERMIN N +D+IA D+ Y+EDPADEFR +  G LLPLWKF +DKT+K+ VT I+++  Y DLF V  G ++ +    +G +C +++KNPS+P+Y + T   V+  D++     L   GL DG V + +L E       +    N    KH +  WQ+KW     D  + F+S+SSDGR+  W + + +L    I+ L + N  +D        L+SG +C+  HP     FLVGT+ G IY   T  S     S Y MT+    H M +Y++ ++ ++ +IF SC ADW + +W   + +PLF+ DLG AV  + WAPYSSTV AAVT + KV V+D ++N+ + +  Q V   K K  LT++ F++    I++GD +
Sbjct:  221 NQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSY--------------MENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFR-EGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNC---KHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFS-----SKYLMTYY--AHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAV-VPKRKNKLTRLSFNEKLAFIVVGDEK 678          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQEN 466
            + L+KP DQL+LTE EL EEITKVL  TN     N+V Y+FKE ++ P P   +T    +   N ++ DS E    +      + + +  P+      V+E  E +N
Sbjct:   43 RQLLKPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIE-----ESDEIGYPLPMPNYTVVEQRETDN 144          

Query:  551 NQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPI--------LPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESG-TCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            NQF YC R   T  NP +   TQ+  PPR  F  N+ Q VIYDSY              + NF  SQK     ++R     EK F D + I        L   +ILERMIN N +D+IA D+ Y+EDPADEFR +  G LLPLWKF +DKT+K+ VT I+++  Y DLF V  G ++ +    +G +C +++KNPS+P+Y + T   V+  D++     L   GL DG V + +L E       +    N    KH +  WQ+KW     D  + F+S+SSDGR+  W + + +L    I+ L + N  +D        L+SG +C+  HP     FLVGT+ G IY   T  S     S Y MT+    H M +Y++ ++ ++ +IF SC ADW + +W   + +PLF+ DLG AV  + WAPYSSTV AAVT + KV V+D ++N+ + +  Q V   K K  LT++ F++    I++GD +
Sbjct:  221 NQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSY--------------MENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFR-EGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNC---KHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFS-----SKYLMTYY--AHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAV-VPKRKNKLTRLSFNEKLAFIVVGDEK 678          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQEN 466
            + L+KP DQL+LTE EL EEITKVL  TN     N+V Y+FKE ++ P P   +T    +   N ++ DS E    +      + + +  P+      V+E  E +N
Sbjct:   43 RQLLKPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIE-----ESDEIGYPLPMPNYTVVEQRETDN 144          

Query:  551 NQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPI--------LPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESG-TCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            NQF YC R   T  NP +   TQ+  PPR  F  N+ Q VIYDSY              + NF  SQK     ++R     EK F D + I        L   +ILERMIN N +D+IA D+ Y+EDPADEFR +  G LLPLWKF +DKT+K+ VT I+++  Y DLF V  G ++ +    +G +C +++KNPS+P+Y + T   V+  D++     L   GL DG V + +L E       +    N    KH +  WQ+KW     D  + F+S+SSDGR+  W + + +L    I+ L + N  +D        L+SG +C+  HP     FLVGT+ G IY   T  S     S Y MT+    H M +Y++ ++ ++ +IF SC ADW + +W   + +PLF+ DLG AV  + WAPYSSTV AAVT + KV V+D ++N+ + +  Q V   K K  LT++ F++    I++GD +
Sbjct:  222 NQFNYCERGALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSY--------------MENFAESQKDGTKKEERKRGKREKKFRDKSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFR-EGEGNLLPLWKFQYDKTKKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVKNPSFPDYIIQTDCGVMCCDIHPTYPFLAVIGLYDGNVAVYNLREDCKEPLYVSRGVNC---KHGECVWQIKWGLDMADGEVNFFSVSSDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGSCMVFHPVDNKIFLVGTECGYIYKCSTAFS-----SKYLMTYY--AHNMSVYRIDFNRFNSNIFVSCGADWMVKVWEDMRPDPLFIFDLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAV-VPKRKNKLTRLSFNEKLAFIVVGDEK 679          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQEN 466
            + L+KP DQL+LTE EL EEITKVL  TN     N+V Y+FKE ++ P P   +T    +   N ++ DS E    +      + + +  P+      V+E  E +N
Sbjct:   44 RQLLKPDDQLDLTEAELGEEITKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIE-----ESDEIGYPLPMPNYTVVEQRETDN 145          

Query:  974 KTRKLPVTSIIWSSFYKDLFVVSHGMYEIVS--FEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKD-----NIMAFYSISSDGRICEWSVNK--YELNCQDIVALRQINLP--IDMETVADRFLES-----GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLF-VLDLGFAVTSIAWAPYSSTVLAAVTVDRK-VRVYDFSINRLEPLVCQVVGSSKHKVSL---TQIVFSDNYPIILIGDSR 1975
            K  +  V+ I +     D+  V++G+Y   S      G++  +S+KNP  PE   +   PV AI+ +     L+  GL DG V +    + SS        S   +     P   ++W+    D     +I  F S+S DG +  + + K  + L    ++  R    P  I +   +    ES     G  I  HP     + V T +G I+         K + +Y   + E    H   +  + +S W P +F +C  DW + IW    + PL  +LD    V    W+P  ST++  VTV+R+   V+DF  N L P+       SKHK+     T   FS     ++IG+ R
Sbjct:  294 KDERKAVSDIDFCRSNGDILAVAYGLYSFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEV---RDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNRHPQGLSITTHPLHKDIYYVLTDEGCIH---------KCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTII--VTVNRETANVWDFRRNLLRPM-------SKHKMDSSFNTVARFSHCGRTLVIGNER 629          

Query:  974 KTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ-----GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKD-----NIMAFYSISSDGRICEWSVNK--YELNCQDIVALRQINLP--IDMETVADRFLES-----GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLF-VLDLGFAVTSIAWAPYSSTVLAAVTVDRK-VRVYDFSINRLEPLVCQVVGSSKHKVSL---TQIVFSDNYPIILIGDSR 1975
            K  +  V+ I +     D+  V++G+Y   SF  Q     G++  +S+KNP  PE   +   PV AI+ +     L+  GL DG V +    + SS        S   +     P   ++W+    D     +I  F S+S DG +  + + K  + L    ++  R    P  I +   +    ES     G  I  HP     + V T +G I+         K + +Y   + E    H   +  + +S W P +F +C  DW + IW    + PL  +LD    V    W+P  ST++  VTV+R+   V+DF  N L P+       SKHK+     T   FS     ++IG+ R
Sbjct:  374 KDERKAVSDIDFCRSNGDILAVAYGLY---SFSSQHVPTSGSVFLWSIKNPGEPERAYYYDVPVTAINFSPFLPSLLAIGLYDGSVEV---RDVSSLQDTPVAVSQRSTSPGSSPVVAIRWIKQVSDDDHETDIDPFLSLSQDGSVTRFRIIKSPFLLGFTQMILERVEGHPEGIFVHPSSRIPCESNRHPQGLSITTHPLHKDIYYVLTDEGCIH---------KCSINYQHQYLEVLRCHDGGVTVMEFSPWSPKLFLTCGNDWFVRIWVDGITRPLLELLDEMTPVHWAKWSPTHSTII--VTVNRETANVWDFRRNLLRPM-------SKHKMDSSFNTVARFSHCGRTLVIGNER 709          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVH-EKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQIN-LPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            +TLVKPPDQL+LTE+EL+EEIT+VL A NP AP N+V+Y+FKE  YK + ++D   IHF ++ NLV+K+S E    ++     +D      +E   N+ ++  ++E                          K +NQF +  RA+QTLNN  +    Q+E PPR  FS   +Q  IYD Y  + +R+ +  + + + F   ++    D+ +  ++  E    DI+ +    KI+ERM+N N FDE+AQDF Y+ED ADEFR +  GTLLPLWKF +DK + L VT++ W+  Y DLF V  G YE    +E+G +  Y+LKNPS+PE+   T S V+ +D++     L+  GL DG V +  L +KS       ++S   S KH    WQVKW   + D+   F+S+S+DGR+  W++ K+E+   DI+ L  ++ +P D++ V      +GT +  H +K H FLVGT+ G I+         K +  YS  F E  + H M +  + W+ +HP++F SC  DW + IW+   ++P+F  +L  +VT +AW+PYSSTV AAVT D KV V+D SIN+ E L  Q V S K +  L  I F+  +PII++GD R
Sbjct:   55 KTLVKPPDQLDLTEEELKEEITRVLTANNPNAPQNVVRYSFKEGCYKTIVFVDQMAIHFELEGNLVHKESDEGRRLMAKHTEREDCGGDERLE---NVPIKPGKREQ-------------------------KVTNQFNFIDRASQTLNNLPREISCQTEPPPRANFSATANQWEIYDFYVEELQRREKSKEKQESQFPNKEE----DRSKKKMIQAEAQSDDISQLAKPAKIIERMVNQNIFDEVAQDFMYFEDAADEFRGEK-GTLLPLWKFQYDKAKGLSVTALCWNHIYSDLFAVGLGSYEFTQ-QERGMLLFYTLKNPSFPEFIFNTDSGVMCVDIHEQLSYLVAVGLYDGCVSVYDLRKKSDQPMYNSIAS---SGKHTGAVWQVKWQKDDLDSNHNFFSVSTDGRVVSWTLVKHEIVFTDIIKLPPVDKVPDDLKNVV---ATAGTSLDFHKQKDHHFLVGTEAGKIH---------KGSKYYSSKFLEMYDAHFMTVSCVRWNPFHPNVFISCGWDWMVKIWDHTINSPVFTFELKSSVTDVAWSPYSSTVFAAVTADGKVHVFDLSINKYEALCQQKVVSKKTR--LLHIEFNPVHPIIIVGDDR 617          

Query:  185 EQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKM-FSDNLDQSVIYDSYEIDF-KRQNRINKSRLTN--FGGSQKIIVPDKKRISLVHE---KHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQIN-LPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE-NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            E  L E+   + +A   AA  ++++++FKE  +KPV   D   I   ++ +LV+KDS                                  +E   + ++                   KS   F     ATQT  NP +    Q+E  P  + +S   +Q  IYD Y+ +  KR +   K    N    G++ +       +SL+ +   K   D+  +    K+LE  +N N   +I  DF ++ED ADEFR D  GTLLPLW+F ++K + L V+++ W+  Y DLF V  G ++    E  G +  Y+ +N ++PE+   T S V+ +D++     L+  GL +G V + +L  K    P+   +S   S KH    WQVKW   +      F+S+S+DGR+  W++ KYEL   +I+ L  ++ +P D+  V    + +G  +  H +K + FLVGT+ G I+         K ++ Y+        H  ++  + W+ ++P +F +C  DW + IW+    +P+F  DL  +V  +AWAPYSSTV AAVT D KV V+D SINR E L  Q V S+K    LT I F+  +PII++G+ R
Sbjct:   10 ESNLSEKTVVLRRARLNAATSSLMRFSFKECCFKPVA--DEPDIE--IEGSLVHKDS----------------------------------EEGQILCAEKEV--------------GRKSKTLFSCITTATQTTINPPREVACQTESQPLLVNYSATANQWEIYDFYQEELQKRTSSTKKDEKENEIAEGAEGV----HGNLSLLRDFTDKSDHDLAMLSTAAKLLEYAVNENINGDIIADFKHFEDEADEFRGDK-GTLLPLWEFQYNKVKSLHVSALCWNKKYNDLFAVGLGSHKFTELE-CGMLLFYTWRNNNHPEFLFNTDSGVMCVDIHEQKSHLVAVGLFNGNVCVYNLMAKDD-QPI--YNSMASSGKHSGTVWQVKWWEDDLYGNHTFFSVSADGRVVSWTLGKYELFSTNIIKLPPMDKVPDDLNNV---IVTAGLTLDFHKQKPYHFLVGTEAGKIH---------KGSTHYTRFIKTYEAHFRMVSCVRWNPFNPKVFITCGMDWRVNIWDETTDSPVFTFDLKSSVMDVAWAPYSSTVFAAVTADGKVHVFDLSINRFEALCQQRVVSTKRH--LTCIEFNPVHPIIIVGNDR 540          

Query:  536 SNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKM-FSDNLDQSVIYDSYEIDFKRQNRINK--SRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEI----AQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQIN-LPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE-NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
              KS   F     ATQT  NP +    Q+E  P  + +S   +Q  IYD Y+ + +++    K  S  +N    Q+I          +   H  D+  +    K+LE  +N N   +I      DF ++ED ADEFR D  GTLLPLW+F ++K + L V+++ W+  Y DLF V  G ++    E  G +  Y+ +N ++PE+   T S V+ +D++     L+  GL +G V + +L  K    P+   +S   S KH    WQVKW   +      F+S+S+DGR+  W++ KYEL   +I+ L  ++ +P D+  V    + +G  +  H +K + FLVGT+ G I+         K ++ Y+        H  ++  + W+ ++P +F +C  DW + IW+    +P+F  DL  +V  +AWAPYSSTV AAVT D KV V+D SINR E L  Q V S+K    LT I F+  +PII++G+ R
Sbjct:   43 GRKSKTLFSCITTATQTTINPPREVACQTESQPLLVNYSATANQWEIYDFYQEELQKRTSSTKKCSHNSNIQKIQQIARNKNSIFGRIMSDH--DLAMLSTAAKLLEYAVNENINGDIIAAQTSDFKHFEDEADEFRGDK-GTLLPLWEFQYNKVKSLHVSALCWNKKYNDLFAVGLGSHKFTELE-CGMLLFYTWRNNNHPEFLFNTDSGVMCVDIHEQKSHLVAVGLFNGNVCVYNLMAKDD-QPI--YNSMASSGKHSGTVWQVKWWEDDLYGNHTFFSVSADGRVVSWTLGKYELFSTNIIKLPPMDKVPDDLNNV---IVTAGLTLDFHKQKPYHFLVGTEAGKIH---------KGSTHYTRFIKTYEAHFRMVSCVRWNPFNPKVFITCGMDWRVNIWDETTDSPVFTFDLKSSVMDVAWAPYSSTVFAAVTADGKVHVFDLSINRFEALCQQRVVSTKRH--LTCIEFNPVHPIIIVGNDR 510          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLS--SNMHSKKHRDPCWQVKWLPIEKDNIMA-----FYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN--IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVT-SIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS + T    V+ ++W+    DL  V +G  E  +    G +C +SLKNP++P+     +S V A+D + ++   +  G+ DG + I ++ + S   P+   S  +N+H+     P WQ+ W+  E D + A       S+SSDGRI +W ++   + C D++ L+  +L       +   L  G C   HP     +LVGT++G+I+         K +S Y+  + E+   HK  +Y++ WS +  D+F SCS+DWTI +W      P+     G  V   I W+P+ +TV  AV+ + KV ++D  ++ L+P    +V  +   V+ T ++FS     +L+GDS     +Y
Sbjct:  418 LWDFSCELTMGRNVSCMVWNKKNPDLLAVGYGQVEFKN-PNSGLVCCWSLKNPTWPDRVFHCESGVTALDFSASNANQLAVGMYDGTIAIYNV-QTSEQTPITDSSDCANLHTS----PVWQLTWIDHE-DGLAADKGEILVSVSSDGRISKW-IHYKSMECVDLMKLKIHDLQWKRHISS---LTPGMCFDFHPNDSKIYLVGTEEGHIH---------KCSSSYNEQYLESYKAHKRPVYKVTWSPFCSDVFLSCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATVFGAVS-EGKVEIWDLRVSSLDPT---LVNWTSPGVNPTALLFSPETDCVLVGDSEGQVTVY 750          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLS--SNMHSKKHRDPCWQVKWLPIEKDNIMA-----FYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN--IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVT-SIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS + T    V+ ++W+    DL  V +G  E  +    G +C +SLKNP++P+     +S V A+D + ++   +  G+ DG + I ++ + S   P+   S  +N+H+     P WQ+ W+  E D + A       S+SSDGRI +W ++   + C D++ L+  +L       +   L  G C   HP     +LVGT++G+I+         K +S Y+  + E+   HK  +Y++ WS +  D+F SCS+DWTI +W      P+     G  V   I W+P+ +TV  AV+ + KV ++D  ++ L+P    +V  +   V+ T ++FS     +L+GDS     +Y
Sbjct:  418 LWDFSCELTMGRNVSCMVWNKKNPDLLAVGYGQVEFKN-PNSGLVCCWSLKNPTWPDRVFHCESGVTALDFSASNANQLAVGMYDGTIAIYNV-QTSEQTPITDSSDCANLHTS----PVWQLTWIDHE-DGLAADKGEILVSVSSDGRISKW-IHYKSMECVDLMKLKIHDLQWKRHISS---LTPGMCFDFHPNDSKIYLVGTEEGHIH---------KCSSSYNEQYLESYKAHKRPVYKVTWSPFCSDVFLSCSSDWTIQLWRQDLQIPVMGFTSGQRVVFDIMWSPHCATVFGAVS-EGKVEIWDLRVSSLDPT---LVNWTSPGVNPTALLFSPETDCVLVGDSEGQVTVY 750          

Query:  824 LPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLP----LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIM-----AFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETV------ADRFLES---GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENI--HKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LPV+ I    +++N+F        Y+E+  D+    S   + P    LW F+ D T+   V+SI W+    DL  V +G +    F EQ  G  C +SLKN  +PE     +  V A+D +     L+  G+ +G V I ++ + +   PV+  S N    KH  P WQ+KW+  ++ N+         S+ +DGRI  W + K  L+C D++ L++       ++        + F+     G C    PK  + +L GT++G+I+         K +  Y+  F +    HK  +Y++ WS + PD+F SCSADW I +W     +P+    +   AV  I W+P S+ +  AVT +R V ++D   + ++PL   +V  +   V LT I+F+ N   +LIGDS     +Y
Sbjct:  326 LPVI-INPEGVHMNSFLAF-----YHEEDEDKISAVSSNIMSPSLNRLWSFACDVTKGHNVSSISWNKKNSDLLAVGYGQF---GFTEQKGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNLLAVGMYNGTVAIYNV-QNNEDFPVLDSSDN--PNKHTSPVWQLKWIEHDRGNLGDDKGEILVSVCADGRITRWHIRK-GLDCNDLMKLKRTGSEKSKKSSNEKEKKGEAFISRQAPGMCFDFLPKDSNIYLAGTEEGHIH---------KCSCSYNEQFLDTYRGHKGPVYKIAWSPFCPDVFLSCSADWCIHLWQQDVLSPILTFSNTTNAVYDIMWSPSSALMFGAVTENR-VEIWDLGTSTIDPL---IVNEANPGVKLTSILFAKNTNCVLIGDSDGQVNVY 712          

Query:  842 LERMINLNTFDEIAQDF------SYYEDPADEFRFDSHGTLLP----LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIM-----AFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETV------ADRFLES---GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENI--HKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            +ER++  NTF      +      + +E+  D+    S   + P    LW F+ D T+   V+SI W+    DL  V +G +    F EQ  G  C +SLKN  +PE     +  V A+D +     L+  G+ +G V I ++ + +   PV+  S N +  KH  P WQ+KW+  ++ N+         S+ +DGRI  W + K  L+C D++ L++       ++        + F+     G C    PK  + +L GT++G+I+         K +  Y+  F +    HK  +Y++ WS + PD+F SCSADW I +W     +P+    +   AV  I W+P S+ +  AVT +R V ++D   + ++PL   +V  +   V LT I+F+ N   +LIGDS     +Y
Sbjct:  375 MERVVVENTFQSRLAAYRQLPVIADHEEDEDKISAVSSNIMSPSLNRLWSFACDVTKGHNVSSISWNKKNSDLLAVGYGQF---GFTEQKGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNLLAVGMYNGTVAIYNV-QNNEDFPVLDSSDNPN--KHTSPVWQLKWIEHDRGNLGDDKGEILVSVCADGRITRWHIRKG-LDCNDLMKLKRTGSEKSKKSSNEKEKKGEAFISRQAPGMCFDFLPKDSNIYLAGTEEGHIH---------KCSCSYNEQFLDTYRGHKGPVYKIAWSPFCPDVFLSCSADWCIHLWQQDVLSPILTFSNTTNAVYDIMWSPSSALMFGAVTENR-VEIWDLGTSTIDPL---IVNEANPGVKLTSILFAKNTNCVLIGDSDGQVNVY 767          

Query:  842 LERMINLNTFDEIAQDF------SYYEDPADEFRFDSHGTLLP----LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIM-----AFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETV------ADRFLES---GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENI--HKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            +ER++  NTF      +      + +E+  D+    S   + P    LW F+ D T+   V+SI W+    DL  V +G +    F EQ  G  C +SLKN  +PE     +  V A+D +     L+  G+ +G V I ++ + +   PV+  S N +  KH  P WQ+KW+  ++ N+         S+ +DGRI  W + K  L+C D++ L++       ++        + F+     G C    PK  + +L GT++G+I+         K +  Y+  F +    HK  +Y++ WS + PD+F SCSADW I +W     +P+    +   AV  I W+P S+ +  AVT +R V ++D   + ++PL   +V  +   V LT I+F+ N   +LIGDS     +Y
Sbjct:  375 MERVVVENTFQSRLAAYRQLPVIADHEEDEDKISAVSSNIMSPSLNRLWSFACDVTKGHNVSSISWNKKNSDLLAVGYGQF---GFTEQKGGMACCWSLKNIMWPERIFHCECGVTAVDFSAVHPNLLAVGMYNGTVAIYNV-QNNEDFPVLDSSDNPN--KHTSPVWQLKWIEHDRGNLGDDKGEILVSVCADGRITRWHIRKG-LDCNDLMKLKRTGSEKSKKSSNEKEKKGEAFISRQAPGMCFDFLPKDSNIYLAGTEEGHIH---------KCSCSYNEQFLDTYRGHKGPVYKIAWSPFCPDVFLSCSADWCIHLWQQDVLSPILTFSNTTNAVYDIMWSPSSALMFGAVTENR-VEIWDLGTSTIDPL---IVNEANPGVKLTSILFAKNTNCVLIGDSDGQVNVY 767          

Query:  980 RKLPVTSIIWSSFYKDLFVVSHGMYEIVSFE-EQGAICGYSLK----NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIE-KDNIMAFYSISSDGRICEWSVNK---------YELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMT----------FNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFA-VTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVC 1885
            ++L VTS+ W+S    +   S+G +    +  E+  +C ++L     N + P+  L   S V+ +  + +   LI  GL +G V++       + +P+I  + ++    H D  +QV W+  + + +    +S+SSDG+I  W + K         + L  Q I +  +I+ P   +T         TC++        F+VG + G   Y L  +S++++ +  +M           F  + H   +Y +  S +H ++F S   D    +++  Q+ PL  L L    + SI W+P    V AA + D +V + DF+ +  +P +C
Sbjct:  127 QQLQVTSVSWNS-TGSIIACSYGRFGDGDWSTEKSYVCTWNLDRRGFNANNPDTVLDVPSSVMCLAWHPSQPSLIAGGLFNGDVLV--WDTSRTDDPLIGRTGHV-GDTHTDAVYQVGWMQEKSQGHRHQVFSVSSDGKILVWQMEKEGHLVLLDGFALVAQQIPSNTKIHKPGRGDTAVGV-----TCLSYSHFDPSLFIVGVEGG---YLLKCSSSVQTLAPINMGSSVPLRAPAQFTFSPHGGPVYSVTCSPFHRNLFLSAGTDGHAHLYSMLQAKPLVSLQLSQKYLFSIRWSPVRPLVFAAASGDGEVVLVDFAKSFQKPSLC 442          

Query: 1094 YSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIW--NCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEP-LVCQVVGSSKHKVSLTQIVFSDNYPIILIG 1966
            + ++ P+ PE TL   SP++ ++ N  D  ++  G  +G   I     +   NP   + S +    HRDP ++V WL  +       +S S+DG+I  W + K     + ++      L I  +   D  L     +   P     F+VGT+ G I   ++ N   K+  +  +      H   IY +  + ++P  F +   DWT  IW  +CR+S+ ++       +T   W+P   TV     +D  + V+D+   +  P L  +V G       L  I   DN   +  G
Sbjct:  233 WDIEIPNKPELTLKPVSPLVCLEYNPKDSHVLVGGCYNG--QIAYWDTRKGGNP---MESTVIEHSHRDPVYKVIWL--QSKTGTECFSASTDGQILWWDIRKLSEPTEKLI------LDISKKENLDNAL-GAVSLEFEPTLPTKFMVGTEQGMI---VSCNRKAKTPPE-KIVCTYGGHHGPIYSIQRNPFYPKNFLTV-GDWTARIWSEDCRESSIMWTKYHMSYLTDACWSPTRPTVFLTTKMDGTLDVWDYMYKQNNPSLSVKVSGE-----PLYSIRMQDNGRFVACG 502          

Query:   35 MPLKPFEKRK-SNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENL------EQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            MP K   K+  S     +R+D+D  T      +     +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YK + +++   +HFS   NL+           Y+D M A S  S+     +       E       E         Q +    ++T+    +E           K +NQF +  RA+QT NNPL+ +  Q E PPR  FS   +Q  IYD+Y +D   +    K +        K       R     E    DIT +    KI+ERM+N NT+D++AQDF YYED ADE+R D  GTLLPLWKF  DK ++L VT++ W+  YKDLF V HG Y+ +  + +G +  YS+KNPS+PEY   ++S ++ +D++++   L+  G  DG V I +L +K  S P  R +S   S KH DP WQVKW   + D+ + F+S+SSDGRI  W++ K EL   DI+ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  ++W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  V+D ++N+ E +  Q V  +K K  +T + F+  +PII++GD R +
Sbjct:    1 MPSKQIRKQSISVTRGARRRDEDSGTDVGEGTDEWSQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKLIGFVNQMAVHFSQVGNLIPKDSDEGRRQHYRDEMVAGSQESIKVVTSEAENLEEEEEPKEGEGEAEAEAEAGSQTDIPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAY-VDELEKQEKTKEKEKAKTPVAKKTEKMAMRKLTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDTADEYR-DQEGTLLPLWKFQNDKAKRLAVTALCWNPKYKDLFAVGHGSYDFMK-QSRGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVVGYYDGNVAIYNL-KKPHSQPCFRSTSK--SGKHTDPVWQVKWQKDDMDHNLNFFSVSSDGRIVSWTLVKSELVHIDIIKLKTEGSTTEIPEGLQLHTVGCGTAFDFHKEIDYMFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMAVDAVLWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQPV-VAKKKNKITHVQFNPIHPIIIVGDDRGH 654          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEK-----DNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLES--------GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS D T+ L V+S+ W+    DL  V +G +    F EQ  G  C +S+KNP +PE    +   V ++D + +   L+  G  +G V I ++    SS+ +  L S+   +KH  P WQV+W+  ++     D      SIS+DGRI +W + K  L+C D++ L++       +                 G C A HPK  + +L GT++G I+       +   N  Y  T+    HK  +Y++ W+ + PD+F SCSADW + IW+     P        + V  ++W+P S+ + AA   +R V ++D  I+ L+PL+  V       +  T ++F+     +L+GDS     +Y
Sbjct:  434 LWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNF---GFREQKKGMACCWSIKNPMWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQ---SSHNIPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDKREILVSISADGRISKWIIRK-GLDCHDLMRLKRTTATGGKKGGEKEKKGEALISRQAPGMCFAFHPKDTNIYLAGTEEGLIH-----KCSCSYNEQYLETYRG--HKGPVYKVTWNPFCPDVFLSCSADWGVMIWHQDTVKPFLSFYPTTYVVYDVSWSPKSAYIFAAANENR-VEIWDLQISTLDPLIVNVANPG---IKFTTVLFAKETDCLLVGDSDGQVAVY 778          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEK-----DNIMAFYSISSDGRICEWSVNKYELNC 1417
            LW FS D T+ L V+S+ W+    DL  V +G +    F EQ  G  C +S+KNP +PE    +   V ++D + +   L+  G  +G V I ++    SS+ +  L S+   +KH  P WQV+W+  ++     D      SIS+DGRI +W + K  L+C
Sbjct:  434 LWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNF---GFREQKKGMACCWSIKNPMWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQ---SSHNIPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDKREILVSISADGRISKWIIRK-GLDC 588          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEK-----DNIMAFYSISSDGRICEWSVNKYELNC 1417
            LW FS D T+ L V+S+ W+    DL  V +G +    F EQ  G  C +S+KNP +PE    +   V ++D + +   L+  G  +G V I ++    SS+ +  L S+   +KH  P WQV+W+  ++     D      SIS+DGRI +W + K  L+C
Sbjct:  434 LWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNF---GFREQKKGMACCWSIKNPMWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQ---SSHNIPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDKREILVSISADGRISKWIIRK-GLDC 588          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEK-----DNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLES--------GTCIALHPKKYHTFLVGTQDGNIY 1564
            LW FS D T+ L V+S+ W+                               NP +PE    +   V ++D + +   L+  G  +G V I ++    SS+ +  L S+   +KH  P WQV+W+  ++     D      SIS+DGRI +W + K  L+C D++ L++       +                 G C A HPK  + +L GT++G I+
Sbjct:  111 LWSFSCDLTKGLNVSSLSWNK-----------------------------ANP-WPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQ---SSHNIPVLDSSESPQKHLGPVWQVQWIEQDRGTTGDDKREILVSISADGRISKWIIRK-GLDCHDLMRLKRTTATGGKKGGEKEKKGEALISRQAPGMCFAFHPKDTNIYLAGTEEGLIH 293          

Query:   83 KRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQE-----NSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENI--HKMIIYQLVWSNWHPDIFASCSADWTIGIWN-CRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            K+ DDD         E     ++L+KP DQL L +QEL+EE T++L A NP AP NIV+Y+FK+  +K   ++D   IHFS+D N+++KDS EA          +  S     E       E+ EQ+           + ST    EA ++       K +NQF +  RA+QT NNP + + TQ+E PPR  FS   +Q  IYD+Y  D ++Q +  + +                 +    E    D++ I    KI+ERM+N NTFD+++QDF YYED +DEFR D  GTLLPLWKFS+DK+++L VTS+ W+  YKDLF V+HG Y+ +  + +G I  Y+LKNPS+PE+   T S V+ ID+      LIC G  DG V + ++   + +NPV +  S   + KH DP WQV W   + DN + F+S+SSDGR+  W++ K EL   D++ L+  + P D  E      L  GTC   H +  + FLVGT++G I+         K +  YS  F +    H M +Y+++W+++HP IF SCSADW++ IW+   ++ P+F  DLG AV  +AWAPYSSTV AAVT D KV V+D ++N+ EP +C+     K K  LT I F+ N+PI+L+GD R Y
Sbjct:   37 KKDDDDATEAGEHGGEEWMQTKSLIKPDDQLELNDQELKEEFTRILTANNPHAPQNIVRYSFKDCSFKQTSHVDQLAIHFSLDGNMIHKDSDEARRQQQRHGASEAISEQAISEAGEEKKEEDGEQKTEEPKEGEKRDEESTPAPAEAKSDQ------KLTNQFNFSERASQTYNNPYRERGTQTEPPPRANFSSTANQWEIYDAYMEDLEKQEKAKEKKAAPSKKDDDKSKKKLTAL----ETQSDDMSRISHAAKIIERMVNQNTFDDVSQDFKYYEDMSDEFR-DQEGTLLPLWKFSYDKSKRLAVTSVCWNPKYKDLFAVAHGSYDFMK-QSRGMILFYTLKNPSFPEFVYPTDSGVMCIDIRPEHPYLICVGYCDGSVGVFNV-TSTDANPVFQ--STAKTGKHTDPVWQVAWQKDDLDNNLNFFSVSSDGRVVAWTLVKNELTYTDVIQLQLDSAPQDGPEGTQLTPLGCGTCFDFHKQTDYLFLVGTEEGKIH---------KCSKAYSSQFLDTFEAHHMAVYKVMWNHFHPKIFISCSADWSVKIWDHTYRNGPMFTFDLGSAVGDVAWAPYSSTVFAAVTADGKVHVFDLNLNKYEP-ICEQAVVQKKKTKLTHITFNPNFPIVLVGDDRGY 653          

Query:   38 PLKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALR-QINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            P  P ++  S     +++D+D  T+   + E  D +   +  VKPPDQL+LT+ EL+EE T++L A NP AP NIV+Y+FKE  YK + ++D   +HF+   NL+           Y+D + A S  S    +   S    +E +          +    + + S    +E           K +N+F +  RA+QT NNPL+ +  Q E PPR  FS   +Q  IYD+Y  + ++Q +  +   T    ++K+     ++++ + E    DIT +    KI+ERM+N NT+D++AQDF YYED ADE+R D  GTLLPLWKF  DK ++L VT++ W+  Y DLF V HG Y+ +  + +G +  YS+KNPS+PEY   ++S ++ +DM+++   L+  G  DG V I +L +K  S P  R  S+  S KH DP WQV+W   + D+ + F+S+SSDGRI  W++ K EL   D++ L+ + +    +E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  + W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT + K  V+D SIN+ E +  Q V  +K K  LT + F+  +PII++GD R +
Sbjct:   13 PPPPRKQSISMGRGARKRDEDSGTE---VGEGTDEWVQSKATVKPPDQLDLTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKLIGFVDQLAVHFTQVGNLIPKDSDEGRRQHYRDELAASSQESAKVVI---SETEILEEEEEPKEVEAGSQTDVPIVEASEKMAEEELMTPKQPKERKLTNKFNFSERASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAYMEELEKQEKTKEKEKTKTPVAKKMGKMAMRKMTSM-ESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDAADEYR-DQEGTLLPLWKFQNDKAKRLAVTALCWNPKYNDLFAVGHGSYDFMK-QSRGMLLLYSMKNPSFPEYIFSSESGIMCLDMHVDHPYLVVVGHYDGNVAIYNL-KKPHSQPSFR--SSAKSGKHTDPVWQVRWQKDDMDHNLNFFSVSSDGRIVSWTLVKSELVHTDVIKLKVEGSTTEGLEGLQIHTVGCGTAFDFHREIDYLFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMAVDAVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTNGKTHVFDLSINKYEAICNQPV-VAKKKNKLTHVQFNPIHPIIIVGDDRGH 655          

Query:   35 MPLKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSV----------HLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            MP K   K+        RK ++    D  + E  D +   +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YK + +++   IHFS   NL+           Y+D + A S  SV     D  +              E +A    E   Q +    ++T+    +E           K +NQF +  RA+QT NNPL+ +  Q E PPR  FS   +Q  IYD+Y +D   +    K +        K       R     E    DIT +    KI+ERM+N NT+D++AQDF YYED ADE+R D  GTLLPLWKF  DK ++L VT++ W+  YKDLF V HG Y+ +  + +G +  YS+KNPS+PEY   ++S ++ +DM+++   L+  G  DG V I +L +K  S P  R +S   S KH DP WQVKW   + D+ + F+S+SSDGRI  W++ K EL   D++ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  ++W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  V+D ++N+ E +  Q V  +K K  +T + F+  +PII++GD R +
Sbjct:    1 MPSKQIRKQSVILTRGARKREEDSGTD--VGEGADDWAQSKAAVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKERTYKLIGFVNQMAIHFSQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVVTSDTEILEEEEEPKEGEGEGEGEAEGEAEAGSQTDVPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAY-VDELEKLEKTKEKEKTKTPVAKKTEKMAMRKLTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDAADEYR-DQEGTLLPLWKFQNDKAKRLAVTALCWNPKYKDLFAVGHGSYDFMK-QSRGMLLLYSMKNPSFPEYMFSSESGIMCLDMHMDHPYLVVVGYYDGNVAIYNL-KKPHSQPCFRSTSK--SGKHTDPVWQVKWQKDDMDHNLNFFSVSSDGRIVSWTLVKSELVHIDVIKLKDEGSTTEIPEGLQLHTVGCGTAFDFHKEIDYLFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMAVDAVLWNPYHARVFISCSSDWTVKIWDHAIKTPMFIYDLNAAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQPV-VAKKKNKITHVQFNPIHPIIIVGDDRGH 658          

Query:   35 MPLKPFEKRK-SNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENL------EQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            MP K   K+  S     +R+D+D  T      +     +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YK + +++   +HFS   NL+           Y+D M A S  S+     +       E       E         Q +    ++T+    +E           K +NQF +  RA+QT NNPL+ +  Q E PPR  FS   +Q  IYD+Y +D   +    K +        K       R     E    DIT +    KI+ERM+N NT+D++AQDF YYED ADE+R D  GTLLPLWKF  DK ++L VT++ W+  YKDLF V HG Y+ +  + +G +  YS+KNPS+PEY   ++S ++ +D++++   L+  G  DG V I +L +K  S P  R +S   S KH DP WQVKW   + D+ + F+S+SSDGRI  W++ K EL   DI+ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  ++W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  V+D ++N+ E +  Q V  +K K  +T + F+  +PII++GD R +
Sbjct:    1 MPSKQIRKQSISVTRGARRRDEDSGTDVGEGTDEWSQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKLIGFVNQMAVHFSQVGNLIPKDSDEGRRQHYRDEMVAGSQESIKVVTSEAENLEEEEEPKEGEGEAEAEAEAGSQTDIPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPLRDRECQMEPPPRTNFSATANQWEIYDAY-VDELEKQEKTKEKEKAKTPVAKKTEKMAMRKLTSMESQSDDITKVTQAAKIVERMVNQNTYDDVAQDFKYYEDTADEYR-DQEGTLLPLWKFQNDKAKRLAVTALCWNPKYKDLFAVGHGSYDFMK-QSRGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVVGYYDGNVAIYNL-KKPHSQPCFRSTSK--SGKHTDPVWQVKWQKDDMDHNLNFFSVSSDGRIVSWTLVKSELVHIDIIKLKTEGSTTEIPEGLQLHTVGCGTAFDFHKEIDYMFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMAVDAVLWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHVFDLAVNKYEAICNQPV-VAKKKNKITHVQFNPIHPIIIVGDDRGH 654          

Query:   44 KPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHY---QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLV-----------YKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            +P ++  S     +++D+D  T+   + E  D +   +  V+PPDQL LT+ EL+EE T++L A NP AP NIV+Y+FKE  YKP+ +++   +H++   NL+           Y+D + A S  SV    +  + +L  + +   +      +     +  +    +E           K +NQF +  RA+QT NNP++ +  Q+E PPR  FS   +Q  IYD+Y  + ++Q +  +        ++K      ++++ + E    D+  +    KI+ERM+N NT+D+IAQDF YY+D ADE+R D  GTLLPLWKF  DK ++L VT++ W+  Y+DLF V +G Y+ +  + +G +  YSLKNPS+PEY   + S V+ +D++++   L+  G  DG V I +L +K  S P     S+  S KH DP WQVKW   + D  + F+S+SSDGRI  W++ K +L   D++ L+      ++ E +    +  GT    H +  + FLVGT++G IY         K +  YS  F +  + H M +  + W+ +H  +F SCS+DWT+ IW+     P+F+ DL  AV  +AWAPYSSTV AAVT D K  ++D +IN+ E +  Q V + K++  LT + F+  +PII++GD R +
Sbjct:   12 QPHKQSISIGRGTRKRDEDSGTE---VGEGTDEWAQSKATVRPPDQLELTDAELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRRQHYRDELVAGSQESVKVISE--TGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTPKQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEKQEKTKEKEKAKTPVAKKSGKMAMRKLTSM-ESQTDDLIKLSQAAKIMERMVNQNTYDDIAQDFKYYDDAADEYR-DQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMK-QSRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNL-KKPHSQP--SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKVEGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIY---------KCSKSYSSQFLDTYDAHNMSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAAVTTDGKAHIFDLAINKYEAICNQPVAAKKNR--LTHVQFNLIHPIIIVGDDRGH 652          

Query:  158 KPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENS---NLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM-ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            KP DQL LT+QEL+EE T++L A NP AP NIV+Y+FK+ QYKP+P +D   +HF M+ NL++++S EA   L   +    ++   PI              +    +       +E  +E++        K +NQF +C RATQT NNPL+ +  Q+E PPR  FS   +Q +I+D+Y+ DF++ N+         G  +      +KR++++ +    D+  I   VK+LERM+N N+FDEIAQDF Y+EDP+DEFR D  GTLLPLWKF ++K RKL VTSI WS  Y DLF +++G Y+ +  + +G +C YSLKNPS+PEY   T S VL   ++     ++CAGL DG V + S  +K    P+ +  S+  + KH DP WQV W   + DN M FYS SSDGR+  W++ K +L  QD++ L     P++  + +    L SGT    H +  H FLVGT++G ++   T  S     S Y  T++   H M +Y++ W+ +HP IF +CSADWT+ IW+  ++ P+FV DL   V   AW+PYSSTV AAVT D KV V+D +IN+ E L  QVV + K K  LT I F+  +PI+++GD R +
Sbjct:   50 KPDDQLQLTDQELKEEFTRILTANNPHAPQNIVRYSFKDRQYKPIPQVDQLAVHFVMEGNLIHRESDEAKKQLEKKS---GDAAREPI--------------DEAAEASEGEAPPKEEGDEDAPAPAASGKKLTNQFNFCERATQTYNNPLRERENQTEPPPRVNFSQTANQWIIFDAYQADFEK-NQEKGKEKKGGGAGKGAEEKARKRLTVM-DTQADDLAKIEHAVKMLERMVNQNSFDEIAQDFKYWEDPSDEFR-DQQGTLLPLWKFGYEKARKLAVTSITWSPKYHDLFAIAYGSYDFMK-QTRGLLCFYSLKNPSHPEYVFETDSAVLTAALHPEYPHMLCAGLYDGSVAVYSAVQKKRG-PLYQ--SSARTGKHTDPVWQVCWAKDDLDNNMNFYSTSSDGRVTSWTLIKNDLVSQDVIKLELEGGPVEGPDGIKLENLASGTTFDFHREASHLFLVGTEEGKVFKCSTAYS-----SQYLQTYD--AHHMAVYKVTWNPFHPSIFMTCSADWTVKIWDHNKTEPVFVFDLNSPVGDAAWSPYSSTVFAAVTADGKVHVFDLNINKYEALCEQVV-AQKKKAKLTHIDFNPKHPILIVGDDRGH 629          

Query:   56 KRKSNAFYLKRKDDDFYTKDPTLNENEDHY--QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINK-SRLTNFGGSQKIIVPDKKRISLVHEKHFGD-ITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQI-NLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGD 1969
            KR+++    ++   D    + +L E  D Y  +  +KP DQL L+EQEL+EEIT+VLK+TNP AP NIV+YNFK+ QY  VP +D   IHF  +S ++  DS EA   +S                D  +  E+L+ E      + +T  K+     +  L   K +NQF +C R+TQT NNP + +   +E PPR  FS N+ Q  IYD Y  DF++Q   NK  +L   G  Q+     K   +++  +  GD ++     +KI+ERMIN NT DEIAQDF YYEDP+DEFR D+ GTLLPLW FSF+K RK+ VTS+ WSS Y DLF V +G Y+ +  +  G IC Y+LKNPSYPEY L T+S VL++D++ +   ++C G  DG V + S+ +  S    +   S   + KH DP W+V+W P + D  + F+SIS+DGR+  W++ K ++   D V L+ I N    +       L+ GT    H  + H FLV T++G ++       +    S Y  T+    H M +Y++ W+ +HPDIF +CSADWT+ IW+  +S P+F  DLG  V  +AWAPYSSTV AAVT D +V VYD SIN+ +PL  Q++ + K+   LT I F+  Y II++GD
Sbjct:    6 KRRTSKKQQRKSQQDAEEFESSLREETDDYGVRAALKPEDQLQLSEQELKEEITRVLKSTNPHAPQNIVRYNFKDGQYTQVPQVDQMAIHFWHESYMLPIDSDEARRQISR---------------DGTMQPEDLQTEEHN--KEPATAVKES----DLQLPQKKVTNQFNFCERSTQTYNNPQRDRGGMTEPPPRANFSANVTQWSIYDDYIEDFEKQQEKNKDKKLLGMGHKQET----KTHKNIISGETQGDELSRFAQPLKIVERMINQNTHDEIAQDFKYYEDPSDEFR-DNQGTLLPLWSFSFEKARKIAVTSLCWSSQYSDLFAVGYGSYDFLK-QSNGLICAYTLKNPSYPEYHLETESGVLSLDLHPSLPYILCVGFYDGAVGVYSILQHKSGPLYL---STARTGKHTDPVWEVRWQPNDLDANLNFFSISADGRVTSWTLIKNDIGKFDAVILKMIANSNEGIGHPRSITLDCGTAFDFHRTQNHIFLVATEEGMVF-----KCSKAYTSQYLATYE--AHHMAVYRVAWNLFHPDIFITCSADWTVKIWDQAKSTPMFTFDLGSPVGDVAWAPYSSTVFAAVTADGRVHVYDLSINKYDPLCNQLIVTKKN-TKLTHIAFNPQYSIIIVGD 610          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLE-----NLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRF-LESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            +T+VKP DQL LTEQE++EE T++L A NP AP NIV+++FKE  +K V  +D   IHFS+D N+++KDS EA   ++     +  +        A    E      ++ E     +QT+   K             K +NQF +  RA+QT NNP + + TQ+E PPR  FS   +Q  IYD+Y  D +RQ +  + +   F G Q+    ++K+IS + E    DIT I    KILERM+N NT+D+IAQDF Y+ED +DE+R +  GTLLPLWKFS++K+++L VTSI W   Y+DL  V HG Y+ +  + +G IC YSLKNPS+PE+   T++ V+ +D++     L+  G  DG V + SL EK    P+ + ++     KH DP W+VKW   + DN M F+SI  DGR+  W++ K EL C D++ L+    P D       F L  GT    H +  + FLVGT++G I+         K +  YS  F +  + H M ++ + W+ +HP IF SCSADWT+ IW    + PLF  DLG +V  +AWAPYSSTV AAVT D KV V+D ++N+ E L  QVV  +K K  LT I F+ NYP+I++GD R Y
Sbjct:   18 KTMVKPDDQLELTEQEMKEEFTRILTANNPHAPQNIVRFSFKEKVFKQVASVDQLAIHFSLDGNMLHKDSDEARRQMARGGLAEAVAEGEEKAEAAGEGGEGEAKPEVKAEKEEGATQTAPAAKG---------GDKKLTNQFNFSERASQTFNNPYRERGTQTEPPPRVNFSSTANQWEIYDAYVEDIQRQEKSKEKK--GFRGQQEST--NRKKISAI-ESQGDDITRIEKPAKILERMVNQNTYDDIAQDFKYWEDVSDEYR-EQEGTLLPLWKFSYEKSKRLAVTSICWDPKYRDLLAVGHGSYDFLK-QTRGLICLYSLKNPSFPEFIYNTETGVMCLDIHPAYPHLVAVGFYDGSVGVFSLTEKIQE-PMYKCTAK--GGKHTDPVWEVKWQKDDLDNNMNFFSIGGDGRVVSWTLVKNELLCTDVILLKLDESPADGAEGTQLFTLGCGTAFDFHKQTDYLFLVGTEEGKIH---------KCSKAYSSQFLDTFDAHHMAVHSVRWNTFHPKIFLSCSADWTVKIWEHTSNMPLFTFDLGSSVGDVAWAPYSSTVFAAVTSDGKVHVFDLNVNKYEALCEQVV-VTKKKTKLTHIEFNPNYPMIIVGDDRGY 608          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENS-NLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRF-LESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTF--NENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            ++++KP DQL LTEQEL+EE+T+VL ATNP AP NIV++NFK+ QY+ +  +D  ++HF  + +++ KDS E    ++    L       P+E +AN                     K+ A+ E +  +   K +NQF +C R+TQT NNP + +   +E PPR  FS N+ Q +IYD Y+ D+++Q    K       G  K     KK+ S     +  D++     +KILERMIN NT DE+AQDF YYEDP+DE+R D +GTLLPLW F+F+K RKL VT++ WS  Y DLF V HG Y+ +  +  G IC Y++KNP YPEY   T S VL++D++     ++C G  DG V + ++++  S  P+    S   + KH DP W+V+W P + D  + F+S+S+DGR+  W++ K ++   D + L+ +    D    +    L+ GT    H    H FLV T++G +Y         K +  YS  +  +   H M +Y++ W+++HPDIF +CSADWT+ IW+  + +P+F+ DLG  V  +AWAPYSSTV AAVT D +V VYD S+N+ EPL  Q+V ++K K  LT + F+  Y II++GD R
Sbjct:   32 RSVIKPDDQLQLTEQELKEEVTRVLTATNPHAPQNIVRFNFKDCQYRQISQVDQASVHFWHEGHMLLKDSDEGRRQMARDGTLPTAG---PVEEEAN---------------------KEGAFVETAEGMQPKKLTNQFNFCERSTQTYNNPHRERGNMTEPPPRATFSANVTQWIIYDDYDADYQKQQEKTKE--KKVAGGPKYEGKQKKKSSHADTLN-DDLSRFAQPIKILERMINQNTHDEVAQDFKYYEDPSDEYR-DQNGTLLPLWNFTFEKARKLAVTALCWSPRYNDLFAVGHGSYDFMK-QSNGLICFYTMKNPEYPEYIFETDSGVLSLDLHHGLPHMLCVGFYDGSVGVYNINQHKSG-PLYM--STAKTGKHTDPVWEVRWQPNDLDANLNFFSVSADGRVTSWTLVKNDMGQFDALVLKMVTSSGDSSEPSQLITLDCGTAFDFHRTLSHLFLVATEEGMVY---------KCSKAYSSQYLGSYEAHHMSVYRVAWNHFHPDIFITCSADWTVKIWDHNKKDPVFMYDLGSPVGDVAWAPYSSTVFAAVTADGRVHVYDLSVNKYEPLCNQLV-TAKKKTKLTHLAFNPKYSIIIVGDDR 603          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSN---KSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINK--SRLTNFGGSQKIIVPDKKRISLVH-EKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVI-RLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRF----LESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            + L+KP DQL LTE EL+EE T++L A NP AP NIV+Y+FKE  YKP   +D   IHF++D N+++KDS EA    +           L  E DA    E  ++EN  + +      ++   + ++++      K +NQF +  RA+QT NNP + + T +E PPR  FS   +Q  IYD+Y  D +RQ ++ +  SR T     Q     D K+  L+  E    DI+ I    KI+ERMIN NT+DEIAQDF Y+ED ADEF+ D  GTLLPLWKFSF+K++++ VTS+ WS  Y DLF V HG Y+ +  +  G +  Y+LKNPS+PEY   T+S V+ +D +      I  G  DG V + ++ ++++   ++ R ++ M   KH DP WQVKW   + DN M F+S+SSDGRI +W++ K EL   DI+ L+Q N P   E   D      L  GT    H    + FLVGT++G I+         K +  YS  F E  + H M +Y + W+++HP IF SCSADWT+ IW+     P+F  DL  +V  +AWAPY+STV AA T D +V VYD ++N+ EPL  Q V ++K +  LT + F+  YP++++GD R Y
Sbjct:   57 KQLIKPDDQLELTEAELKEEFTRILTANNPHAPSNIVRYSFKEKCYKPTSSVDQLAIHFALDGNMLHKDSDEARRQRARQG--------LEAEHDAGEAGEEEDKENKAVEAVEEKPAEEVRPDSSASVGGKSEAKLTNQFNFSERASQTYNNPYRERGTSTEPPPRANFSATANQWEIYDAYVEDLQRQEKMKEKESRKT-----QTFKKDDDKKKKLMQVEVQGDDISRISKPCKIVERMINQNTYDEIAQDFKYWEDAADEFK-DQEGTLLPLWKFSFEKSKRMAVTSLCWSPKYHDLFGVGHGSYDFLK-QSNGMVAMYTLKNPSFPEYICETESGVMCLDFHPEHPNYIAVGFYDGSVGVYTVVQQTNKIELMYRSTAKM--GKHTDPVWQVKWQKDDLDNNMNFFSVSSDGRITQWTIVKSELRHTDIITLKQGNTP---EGEGDNTQLPSLGCGTAFDFHKTMDYMFLVGTEEGKIH---------KCSKTYSSQFLETYDAHHMAVYSVKWNHFHPKIFISCSADWTVKIWDHHYQEPMFTFDLNNSVGDVAWAPYASTVFAACTTDGRVYVYDLNVNKYEPLSEQSV-ANKKRTKLTHLAFNPEYPVLIVGDDRGY 651          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQ----ENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALR-QINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN--IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            + LVKP DQL+L+E EL+EE T+VL A NP AP NIV+Y+FKE  YKP+  +D   IHF ++ NL++KDS EA    +           +P   +A+ VL  +EQ    E++    + +   + ++ +  S     K +NQF Y  RA+QTLNNP + +  Q+E PPR  FS   +Q  IYD+Y  + ++Q +  + + T    S+K     KK++++V E    DIT +  V KI+ERM+  NTFD+IAQDF Y+ED +DEFR +  GTLLPLWKF +DK + L VT++ W   YKDLF V  G Y+    + +G +  YSLKN +YPEY   T S V+ +D++     L+  G  DG V + +L E+    P+ + ++ M   KH DP WQVKW   + DN   F+SISSDGR+  W++ K EL   DI+ L  + ++    E +    +  GT    H +  + FL+GT++G I+         K +  YS  F E    H M +  + W+ +HP +F SCS+DWT+ IW+    +P+F  DL   V  +AW+PYSSTV AAVT D KV V+D SIN+ E +  Q V + K K  LT I F+  YPII++GD R Y
Sbjct:    4 KVLVKPADQLDLSEAELKEEFTRVLTANNPHAPQNIVRYSFKERSYKPISSVDQLAIHFVLEGNLLHKDSDEARRQRA--------KQEIP---EADGVLTCVEQADLTEDTGDAEEGAGEERPDSVDVKSGKMERKVTNQFNYSERASQTLNNPPRERGCQTEPPPRAKFSATANQWEIYDAYVEELQKQEQSKEKQKTLV--SKKEEDKGKKKMTVV-ENPSDDITKVAKVTKIIERMVTQNTFDDIAQDFKYFEDASDEFR-EQEGTLLPLWKFQYDKAKHLSVTALCWLCNYKDLFAVGLGSYKFTK-QGRGMLLFYSLKNSTYPEYIFTTLSGVMCLDIHKQLSSLVAVGFYDGSVGVYNLKEEGP-QPIYKSTAKMG--KHTDPVWQVKWQKDDIDNNHNFFSISSDGRVVSWTLVKNELVFTDIIRLSVEGSISNGQEGMQLPAMACGTSFDFHQQIDYLFLIGTEEGKIH---------KCSKCYSSQFLETYAAHNMAVDAVKWNQFHPKVFISCSSDWTVKIWDHTIKSPMFTFDLNAPVGDVAWSPYSSTVFAAVTTDGKVHVFDLSINKYEAICQQAVAAKKTK--LTHIEFNPVYPIIIVGDDRGY 592          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMA-----FYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLES---GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN--IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGF-----AVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS + T    V+ + W+    DL  V +   +I + ++ G +C +SLKNP +P+     +S V ++D + ++   +  G+ DG ++I ++ + +   PVI  SSN    KH  P WQVKW+  E+++  A       S+++DGR+C+W   +  L C D++ L        M   +   + S   G C   H    + +L GT +G+I+         K +  Y+  F +    HK  + ++ WS + PD+F SCSADWTI +W  RQ   LF   LGF     AV  + W+P  +TV   +  DR V +++   +  +P V  V       V LT ++F+     +L+GDS     +Y
Sbjct:  415 LWAFSCELTVAHDVSCMAWNKKNPDLLAVGYEQLDI-NDQKSGLVCCWSLKNPQWPDRIFQCESAVTSLDFSASNASQLAVGMHDGSIVIYNV-QFTKKTPVID-SSNC-DPKHTGPVWQVKWIDCEQNSAGASEAEMLISVAADGRVCKWFFREC-LTCIDLMKLTV------MRNDSGALISSQAPGLCFDFHRNNSNIYLTGTGEGHIH---------KCSCSYNEQFLDTYKAHKGPVRKVTWSPFCPDVFLSCSADWTIQLW--RQD--LFTPVLGFTSTQNAVHDVMWSPRWATVFGVINEDR-VEIWNLGASTQDPTVVSVANPG---VKLTSLLFASETDCVLVGDSEGRVSVY 748          

Query:  974 KTRKLPVTSIIWSSFYKDLFV----VSHGMYEIVSFEEQGAICGYSLK----NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYE--LNCQDIVALRQINLPIDMETVADRFLESGTCIA-----LHPKKYHTFLVGTQDGNI----YYHLTMNSNMKSNSDYSM----TFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFA-VTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEP 1876
            + R L VT + W+     +      V HG +      E+  +C ++L     NP  P+  + T +PV+ +  +     LI  GL  G V++      S+ +PV+   + +    HR+P ++VKW+P  +   +A  S  S GRI  WSV   E  L+     AL +  +P    +   R    GT I      L P    +FLVG++ G +    +   T+ +   +    ++     F+ +     ++ L +S +H ++F S   D    I +  Q   L  + +  + V  + W+P    V AAVT    V+V+D     L P
Sbjct:  121 QQRGLQVTGVSWNCTGSVIACAYGRVDHGDWST----EKSCVCTWNLDRSKLNPKQPDMVIDTATPVMCVSFHPLRPSLIAGGLYSGEVIV--WDTSSTQDPVL-AQTGISQDTHREPVYEVKWVPGARRGDLAVLSACSGGRILLWSVEAAEGRLSLTSGYALVRQQVPQSSSSNKSR---GGTNIGVTSLTLSPWDLDSFLVGSEGGLVLKCAFSSQTVAAVPPNGESVALRAPAQFSFSARAGPVHSLHFSPFHRNLFVSVGTDGLAQIHSMLQPRALLTMRVSDSYVFGVRWSPVRPLVFAAVTGQGLVQVFDLGRRSLRP 435          

Query:  833 VKILERMINLNT---FDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDK--TRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLK-NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN---IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            ++++ER +  ++   FD   +D    ED   + +    G+ L   +  +D+  ++   +T + WS  Y +L V S+   E    E  G    +++K   + PEY    +SPV+++        L+  G   G +++   +      PV R  + + +  H  P + V  +  +  N +   ++S+DGR+C WS++      + +  +   + P+ +           T +A      + ++VG+++G +Y      S   S +     F  +   +  +  +  V       +F + S DWT+ +W+ + + PL+   D    V  + W+P    + AAV    ++ +++ + +   P     +  +    +L ++ ++     + +GDS    +IY
Sbjct:  201 IRVMERALAEDSNIFFDYSGRDL---EDKEGDLQ---GGSSLSFSRLFYDERWSKHRVITCLDWSPQYPELLVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYIYHCQSPVVSVGFARFHPNLLVGGTYSGQIVLWD-NRSHRRTPVQR--TPLSAAAHTHPVYCVNVVGTQNANNL--ITVSTDGRMCSWSLDMLSQPQESMELVYNKSKPVAV-----------TGMAFPAGDVNNYVVGSEEGTVY----TASRHGSKAGICEMFEGHQGPVTGISCHSAVGPVDFSHLFVTSSFDWTVKLWSTKHNKPLYSFEDNADYVYDVMWSPVHPALFAAVDGMGRLDLWNLNNDTEVPTASVTIEGAP---ALNRVRWASGGKEVAVGDSEGRVWIY 568          

Query:  605 TKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRL----TNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDK--TRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLK-NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHP----DIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
             K+TQ ++PP++M S + +        +   K ++   +  L    +     Q+    D +  +  HE    +   IL   +I+ER ++ +   ++  D+S   D  D+      GT L L +   D+  ++   VT + WS  Y +L V S+   E    E  G    +++K   + PEY    +S V++         L+  G   G +++   +  +   PV R  + + +  H  P + V    +   N     SIS+DG++C WS++        +  + + + P+ +           T ++      + F+VG++DG +Y      S     +  S  F E  H  +          P     +F + S DWT+ +W+ R + PL+   D    V  + W+P    + A V     + +++ +     P     V   +   +L ++ ++++   + +GDS     IY
Sbjct:  112 AKVTQVDFPPKEMVSYSKETQT---PTQTQIKHEDENEEEDLAVVQSALEAPQENESQDTEEEAPPHELTEEEKQQIL--SRIVERALSEHV--DVCFDYSG-RDLQDKEGDTQGGTKLSLNRQFMDERWSKHRVVTCLDWSLQYPELLVASYSSNEEAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAAFARFHPNLVVGGTYSGQIVLWD-NRSNKRTPVQR--TPLSASAHTHPVYCVSL--VGSQNAHNLISISTDGKMCSWSLDMLSTPQDSLELVFKQSKPVAV-----------TSMSFPLGDVNNFVVGSEDGTVYTACRHGSK----AGISEMF-EGHHGPVTGLDCHMAAGPVDFSHLFVTSSFDWTVKLWSTRNTKPLYSFEDNSDYVYDVMWSPAHPALFACVDGVGHLDLWNLNNETEVPTASVTV---EGNPALNRVRWANSGREVAVGDSEGQVHIY 554          

Query:  539 NKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPD---KKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQG--AICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVAL---RQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIW-NCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
             K +NQF +  RA+QT NNPL+ K +Q+E PPR  FS  ++Q  +YD+Y  + KRQ +  + +    GG  +         K+ +LV E    DIT +    KI+ERM+N NTFD+IAQDF Y+ED +DE+R +  GTLLPLW+F  ++ R+L VT++ W+  Y DLFVV  G YE   F++QG  A+  ++LKNPS+PE+   T+S V+ +D++     L+ AGL DG V + +L     + P  R  S+  S KH DP WQVKW   + DN + F+S+SSDGR+  W++ K EL C D+V L        P+  E  A   L SGT    H +  H FLVGT+DG I         +K +  YS  F +  + H M +  + W+ +H  +FASCSADW++ IW +  +  P+F  DLG AV  +AWAPYSSTV AAVT D KV V+D ++N+ E L  Q V + KH   LT + F+ + P++++GD R
Sbjct:    2 QKLTNQFNFSERASQTFNNPLREKSSQTEPPPRANFSATVNQWEVYDAYGEELKRQEKAKEKQQQKGGGGGRRDEGGPRATKKFTLV-ETQGDDITKVAKAAKIIERMVNQNTFDDIAQDFRYFEDASDEYR-EQDGTLLPLWRFQCEQARRLTVTALCWNPCYHDLFVVGFGSYE---FQKQGRGALVVFTLKNPSFPEFVFATESGVMGVDVHDARPHLVAAGLYDGTVAVYNLAAPVDAQPSHR--SSARSGKHTDPVWQVKWQRDDLDNNLNFFSVSSDGRVASWTLIKNELLCMDVVKLSVEEGQAAPLG-EDPALETLSSGTSFDFHRQIDHMFLVGTEDGTI---------LKCSKAYSSQFLDTYDAHHMAVEAVRWNPFHTRVFASCSADWSLKIWEHTAKWAPVFTFDLGAAVGDVAWAPYSSTVFAAVTADGKVHVFDVNVNKYEALCTQSVSTKKH-TKLTHVAFNPSQPVLIVGDDR 473          

Query: 1289 KHRDPCWQVKWLPIEK-----DNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQIN-----LPIDMETVADR-------FLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNEN--IHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGF-AVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYP--IILIGDSRFYYFIY 1993
            KH    WQV+W+ +E+     D      SIS+DGR+  W+V K  L+CQD++ L++           +E   +R        L  GTC+  HP+  + +L GT++G I+         + +  YS    ++   H+  +Y+++WS + P++F SCS+DW++ +W    ++P+  L  G  AV  +AW+P+S T+LAA+T +  + V+D S + L+P+   +V   +  V +T++ FS   P   +L+GDS  +  +Y
Sbjct:    1 KHMGAVWQVQWVRLEQGGGGEDRGETLTSISADGRVTRWAVRK-GLDCQDLMRLKRTGEGRTRRTAGVEGQRERKNEALIWRLACGTCVDFHPQDSNVYLAGTEEGFIH---------RCSCSYSEQHLQSYSAHQGPVYRVLWSPFEPEVFLSCSSDWSVRLWRVDLTSPVLTLQCGSQAVLDVAWSPHSPTLLAALTAE-ALHVWDLSSSTLDPV---LVSPGRRGVHMTRVAFS-RAPGHCLLVGDSDGHVTLY 242          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEA 364
            +TLVKP DQL LTE EL+EE T++L A NP AP NIV+Y+FKE  YKPV  +D   +HF++D NL++++S EA
Sbjct:   19 RTLVKPEDQLELTEAELKEEFTRILTANNPHAPQNIVRYSFKERVYKPVGTLDQLAVHFAVDGNLLHRESDEA 91          

Query:  938 GTLLPLWKFSFDK-------TRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLK-NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPID-METVADRFLE-SGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHP----DIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            G +L   K S ++       +++  +TS+ WS+ Y +L V ++   E    E  G    ++ K   + PEY    +S V++         L+  G   G +++   +  +   PV R  + + +  H  P + V  +  +  N     S+S+DGR+C WS             L  ++ P D ME V  +    + TC+       + F+VG+++G++Y          S +  S  F E     +      S   P     +F + S DWTI +W  + + PL+   D    V  + W+P   ++ A+V    ++ +++ + +   P     +       +L ++ ++ +   + +GDS  + +IY
Sbjct:  220 GEVLAGAKLSLNRQFYDERWSKRRVITSLDWSAQYPELLVATYNNNEDSPHEPDGVALVWNTKFKKTTPEYVFHCQSAVMSASFARFHPNLVVGGTYSGQIVLWD-NRSNRMTPVQR--TPLSAAAHTHPVYCVNVVGTQ--NAHNLISVSTDGRMCSWS-------------LDMLSQPQDSMELVHKQSKSIAVTCMTFPVGDVNNFVVGSEEGSVY----TACRHGSKAGISEVF-EGHQGPVTGIHSHSAAGPIDFSHLFLTSSFDWTIKLWTTKNNKPLYSFEDNSDYVYDVMWSPVHPSLFASVDGMGRLDLWNLNSDTEVPAASVTIDGCP---ALNRVRWTHSGRELAVGDSEGHLWIY 560          

Query: 1634 HKMIIYQLVWSNWHP--DIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRL-EPLVCQVVGSSKHKVSLTQIVFSDNYPIILIG 1966
            H+  IY L   ++ P  D   S S D T+ IW+ R       L +   VT++A +P     +AA ++DR VRV+D     L E L  +    + HK S+  +VF+ +   ++ G
Sbjct:  484 HEQDIYSL---DYFPSGDKLVSGSGDRTVRIWDLRTGQCSLTLSIEDGVTTVAVSPGDGKYIAAGSLDRAVRVWDSETGFLVERLDSENESGTGHKDSVYSVVFTRDGQSVVSG 594          

Query:  146 QTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAV-----SNLSVPAFLDDNSVHLPIEFDANIVLE---NLEQENSTMLSQTSTTFKQEAW-NENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINK--SRLTNFGGSQKIIVPDKKRISLVH-EKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFY 1981
            + L+KP DQL L+E EL+EE T++L A NP AP NIV+Y+FKE  YK    +D   IHF++D N+++KDS EA        LS+       S+ LP E + +   E   + E +            + E+     S+    K +NQF +  RA+QT NNP + + T +E PPR  FS + +Q  IYD+Y  D +RQ +I +  SR T     Q +   + K+  L   E    DIT I    +I+ERM+N NT+D+IAQDF Y+EDP+DEFR +  GTLLPLWKFS++K+++L VTS+ W+  Y DLF V+HG Y+ +  +  GA+  +SLKNPSYPEY + T+S V+ +D++     ++ AG  DG V + S+ EK  + P+ +  S   + KH DP WQVKW   + DN + F+S+SSDGR+ +W++ K EL+  DI+ L         E    + L  GT    H    + FLVGT++G I+         K +  Y+ T+ +  + H M +Y + W+ +HP  F SCSADWT+ IW+     P+F  DL  +V  + WAPY+STV AA T D K+ VYD ++N+ EPL C+    +K K  LT + F+ ++PI+++GDSR Y
Sbjct:   15 KQLIKPDDQLELSEAELKEEFTRILTANNPHAPSNIVRYSFKERCYKQTSSVDQLAIHFALDGNMLHKDSDEARRQRTRQGLSLVLIYSFISLFLPYEAETSEAGEEDADKENKPEEEKKTDEEKPRSESIIGTGSSKKEQKLTNQFNFSERASQTYNNPYRERGTATEPPPRANFSASANQWEIYDAYVEDLERQEKIKEKESRKT-----QTLKKEEDKKKKLTQVEMQGDDITRISKPAQIVERMVNQNTYDDIAQDFKYWEDPSDEFR-EPDGTLLPLWKFSWEKSKRLAVTSLCWNPIYNDLFSVAHGSYDFLKQDGGGAMSFFSLKNPSYPEYGIKTESGVMCLDIHPEHPHMLAAGFYDGSVAVYSISEK-MNKPLHQ--STAKTGKHTDPVWQVKWQKDDLDNNLNFFSVSSDGRVVQWTIVKSELSHTDIINLELPEKSEGPEGTQIKSLGCGTSFDFHKTINYLFLVGTEEGKIH---------KCSKTYTSTYLDTFDAHHMSVYSVRWNPFHPKTFISCSADWTVKIWDHTHLEPMFTFDLNSSVGDVQWAPYASTVFAACTADGKIHVYDLNVNKYEPL-CEQSVVAKKKSKLTHLAFNPDHPILIVGDSRGY 621          

Query: 1115 YPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEK-------DNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDM----------ETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMI--IYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLF-VLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            YPE      + V A+D +     L+  GL DG + I ++     S     L S+    KH  P WQ++W+  E+       D I+   SIS+DGR+ +WS+ K      D++ L++IN+              + +  RF  +G C    P   + +L GT++G+++         K +  Y+  + E+ H     IYQ+ W+  +P+ F +CSADW++ +W+C +  P+   L    +V  I+W+P  +T+ A V  DR V ++D S+N L+P+V  V         LT ++F+ N   IL+GDS     +Y
Sbjct:    9 YPERVFHLNTGVTALDFSGAHPNLLAVGLYDGTIAIYNIRCTDDSPA---LDSSESVGKHTSPVWQLQWVDREQGGNGDEHDEILV--SISADGRVTKWSIRK-GFESADLMKLKRINVTKQKAGGGGSERKSDALISRF-AAGFCFDFSPNDANIYLAGTEEGHVH---------KCSCSYNEQYLESFHGHTGPIYQVKWNPLYPEAFLTCSADWSVRLWHCDRQFPVMSFLSSTKSVNDISWSPDCATLFACVN-DRAVEIWDLSLNTLDPVVSFV---PVQDCKLTTVLFALNTATILVGDSEGQVTVY 301          

Query:  983 KLPVTSIIWSSFYKDLFVVSHGMYEIVSF-EEQGAICGYSLK----NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWL--PIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVA---LRQINLPIDMETV-ADRFLESG-TCIALHPKKYHTFLVGTQDGNIYYHLTMNS------NMKSNSDYS--MTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFA-VTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPL 1879
            +L +TS+ W+S    +   ++G  +   +   + ++C ++L     N +  + T+   S +L++  +     LI  G  +G V +  L   S  + ++  SS M +  HR+P  ++ WL  P  K       S S DG++  W V   E     +V    L+   +P  + T  A   +E G T ++   +    F++G++ G I+   ++NS      N+ S+      +TF    H   ++ +  S +H ++F +C  D TI ++   Q+ PL  L+     + +I W+P    V +  T D ++ +YD  +N + P+
Sbjct:  121 QLQITSLSWNS-TGSVIAAAYGRLDHEDWCTHKSSLCTWNLDRRGINVNKADTTVDLSSCLLSLAFHPKSPALIAGGTFNGEVHLWDL---SCEDEMLVASSGMGNDSHREPVNKIMWLLDPDSKGKKYQILSASGDGKVLLWQVPPIESQDLRLVGGYILQTGAVPRSLRTSKAKGDMEMGVTTLSFSHEDKTLFVLGSEAGGIF-KCSVNSRGPPVGNVTSSVPLGSPVTFAFAPHVGPVFSVNCSPYHRNLFLTCGTDGTIRLYTMLQAKPLLSLEPAAGYLFAIRWSPVRPLVFSVATGDGRLLIYDMKVNHINPV 435          

Query:  830 VVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTL-LPLWKFSFDK--TRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLK-NPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
             V+++ER +  +   +I  D+S  E   D+    S     L L +  +D+  +R   VT + WS+ Y +L V S+   E    E  G    ++LK   + PEY    +S V++         LI  G   G +++   +  S   PV R   +  +  H   C  V    +   N     S+S+DG++C WS+        D+++  Q ++ +  +      +   TC++      + F+VG+++G +Y      S    +  +   +   +  +  +          +F + S DWT+ +W+ +   P +   D G  +  + W+P    + A V    ++ +++ + +   P+      S     +L  + ++ +   I +GD     +IY
Sbjct:   82 AVRLVERALTEDL--DITIDYSGAE--GDDLEGGSQAARELTLSRDFYDERWSRHRTVTCLDWSNQYPELLVASYNNNEDAPHEPDGVALIWNLKFAKTTPEYIFHCQSAVMSATFAKFHPNLIIGGTYSGQIVLWD-NRSSKRTPVQRTPLSATAHTHPVYCVNV----VGTQNAHNLISVSTDGKMCSWSL--------DMLSQPQDSMELQYKQSKSVAV---TCMSFLAGDVNNFVVGSEEGTVYTACRHGSKAGISDVFEGHYGP-VTGIDTHSASGPIDFSHLFLTSSFDWTLKLWSHKSPRPYYSFEDNGDYIYDVKWSPIHPALFATVDGTGRLDLWNLNSDTEVPIASTATES---LTALNNVQWTQSGQQISVGDDDGRVYIY 450          

Query:  983 KLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICG----YSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIW--NCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYD 1852
            K   TSI W   Y D        Y ++ F++   IC     + + NP+ P+  L   SP++ ++ N  D  L+  G  +G +       +  S+PV         K HRDP ++  +L  +  +    +S S+DG++  W + K     + ++       P  +          G  +   P     F+VGT+ G++   L+ N   K+ +D  +  +   H   +Y +  + + P  F +   DW   IW  + R+S+ ++       +T   W+P    V     +D  + V+D
Sbjct:  161 KRTATSISW---YPDGTQKLAVAYSVLEFQKSTDICMDSYIWDIDNPTKPDMVLKPVSPLICLEYNPKDPHLLIGGCYNGQLGFWDT--RKGSHPV---EMTPIEKSHRDPIYKTIFL--QSKSGTDCFSTSTDGQVLWWDIRKLGEPTESLLLCPNKKDPRPL---------GGVSLEFEPTMPTKFMVGTEQGSV---LSCNRKAKTPAD-KIVASYAGHYGPVYSVQRNPFFPKNFLTI-GDWQARIWSEDLRESSIMWTKCGMSYLTDGCWSPSRPGVFFTTKMDGTLDVWD 432          

Query:  773 KRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            ++ +L+ E    +++ I    K++ER +  N+  +IA DF +YEDP+DEF     GTL+PLW F +  T+ L V+++ W+  Y D+F V  G  +    +  G +  YSLKNP+YPEY   T S V  +D++ +   L+ AG  DG V + +L +     PV   +S+  + KH DP  Q+ W   + +N   FYS+S DG+I  W++ K  ++   +    Q    + +  + +   +           Y   LV       ++  +M         Y      + H + +  + W+ +HP +F SCS D T+ IW+   + P+  +DL   V  +A++P++STV AAVT    V  YD SI+  E  +CQ    +K K  LT++ F+  + II+IGD +
Sbjct:   21 RKKTLLMETKIDELSKIRESCKLMERAVVQNSLCDIAIDFKFYEDPSDEF-IGHEGTLMPLWNFRYKGTKHLTVSALCWNRRYLDMFAVGMGTEDYFDQQCGGMVLIYSLKNPTYPEYAYKTASGVRCVDIHPHKSYLVAAGFYDGNVAVYNL-KVEKLKPV--CASSPETGKHMDPVIQLCWQKDDINNNHNFYSVSLDGQIVSWTLVKVNMH---VYVFSQYLEVLQLYLLLNLSFDP---------LYGQILVFF----FFFQCSMTYTGHPMEVY------DAHLLSVGTVKWNPFHPKVFISCSCDMTVKIWDHTVTTPISNIDLKEPVEDVAFSPHTSTVFAAVTRRGTVYFYDVSISIYEA-ICQQEVVNKRKGQLTKLEFNPIHLIIIIGDGK 394          

Query:  662 QSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIW-----------SSFYKDLFVVSHGMYEIVSFEEQ--GAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNE--NIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            Q VIYD+Y+ + K++       L                  L      G    +L   KIL  +     FD +  DF +YEDP+DEF     GTL+PLW F +  T+ L V+++ W            + +  +FV S  ++    F++Q  G +  YSLKNP+YPEY   T S V  +D++ +   L+ AG  DG V + +L +     PV   +S+  + KH DP  Q+ W   + +N   FYS+S D                                       S T I  H    + FLVGT +G I         +K +  Y+    E  + H + +  + W+ +HP +F SCS D T+ IW+   + P+  +DL   V  +A++P++STV AAVT    V  YD SI+  E  +CQ    +K K  LT++ F+  + II+IGD +
Sbjct:    6 QWVIYDAYKKELKKRQEQEGGHL------------------LKENSDTGRKKTLLMETKIL--LFFFFYFDSLI-DFKFYEDPSDEF-IGHEGTLMPLWNFRYKGTKHLTVSALCWMQSIHTCTNLKKNVFICVFVSSVLLFPEDYFDQQCGGMVLIYSLKNPTYPEYAYKTASGVRCVDIHPHKSYLVAAGFYDGNVAVYNL-KVEKLKPVC--ASSPETGKHMDPVIQLCWQKDDINNNHNFYSVSLD--------------------------------------VSCTSIDFHKDIPNLFLVGTLEGMI---------LKCSMTYTGHPMEVYDAHLLSVGTVKWNPFHPKVFISCSCDMTVKIWDHTVTTPISNIDLKEPVEDVAFSPHTSTVFAAVTRRGTVYFYDVSISIYEA-ICQQEVVNKRKGQLTKLEFNPIHLIIIIGDGK 385          

Query:  953 LWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKW------LPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVAL-RQINLPIDMETVADRFLES------GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVT-SIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            LW FS + TR   V+S+ W+    DL  V +G ++  + E  G +C +SLKNP++PE  +  +S V ++D +      +  GL DG + I  +    S +  + L S+    +H  P WQ++W      LP E + +    S+ +DGRI +W V    L   +++ L R I    D +T                C+  HP +   +L GT +G I+       +  +N  Y  T+ +  H   +  + W     DIF SCSAD TI +W   Q NP+        V   I W+P  +TV AAV  D ++ V+D +++ L P++ Q    +   V L  ++F+ +   +++GDS     +Y
Sbjct:  381 LWAFSCELTRGFSVSSMAWNKKNPDLLAVGYGEFDSTN-ERAGLVCCWSLKNPTWPERVVRCESAVTSLDFSATRPSHLAVGLFDGSIAIYDIQNPDSIS--LFLDSSKCPSRHLGPVWQLRWNQQEFGLPAE-ERLEVLISVGADGRIIKWVVCTGNLGHTELMKLKRTIYKNPDAKTTESISQSLISSLIPALCLDFHPTEPGIYLTGTWEGLIH-----KCSCSNNQQYLDTYRK--HYCAVNYVAWCPLSDDIFLSCSADCTIQLWTQNQHNPMLSFSTTRKVVHDIKWSPKWATVFAAV-YDEQLEVWDLNLSCLSPVIVQ---PALPGVRLASLLFASHTDCVVVGDSCGQVTVY 726          

Query:  932 SHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKW-------LPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLES-------GTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVL-DLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSRFYYFIY 1993
            S  T+ PLW F  + T    +TS+ W+    ++  VS+   +  S      IC +SL NP +P+      S V ++D + +DH  +  G+ DG V I ++  +     V   +S+    +H  P WQV W         +E + ++   S+S+DGRI  W      L C D++ +R+I+       V+    E+       G C+  HPK+   +LVG+ DG + +  ++N+N +    Y        H + +  + WS + PD+F SCS+D TI +W     +PL     +   V ++ W+P  STV AA+   ++V V++ S N L P+   VV  +   V+LT ++F+     +L+GDS     +Y
Sbjct:  381 SSPTIKPLWTFDSELTTGRMITSMTWNKKNLNILAVSYSDCD-PSSSRASFICCWSLNNPLWPQRIFSCPSRVASMDFSSSDHGHLAVGMYDGSVAIYNVQIQDRGACVA--TSSKCPNRHLRPVWQVAWNKQESKFSGLEAEEVLV--SMSADGRISMWQRCNNHLECIDLMKIRRIHDDKRGNGVSKMVGETILSEVSPGHCLDFHPKESDIYLVGSWDG-LIHKCSLNNNQQFLDSYQK------HLLAVNDIQWSPFSPDLFLSCSSDCTIQLWRHTCLSPLLSFKSVHSQVCAVRWSPERSTVFAAI-YRQQVEVWELSSNILSPV---VVHHAAAGVTLTALLFARGTDCVLVGDSEGKVTVY 733          

Query:  992 VTSIIWSSFYKDLFVVSHGMYEIVSFE-EQGAICGYSLKN----PSYPEYTLFTKSPVLAIDMNINDHR-----LICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKY--ELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNS---------DYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFA-VTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIIL 1960
            VTS+ WS     +   ++G  +   +  E+  +C ++L+      + P   +   S V A+  + N        L+  GL +G V++ +  +  + +PV    + M S  HR+P +QV W+P++K       S  S GR+  W V+ Y   L   D  AL +  +P  +       +   T +AL P    TFLVG+ +G +    + +S M +                F    H   +Y L  S +H ++F S   D    I +  Q++PL  L +  + V  + W+P    V AA +    V+++D     L P      G + H  + T + F+ + P +L
Sbjct:  129 VTSVSWSC-TGSVVACAYGRTDDGDWSTERSCVCLWNLEQRGLQSNQPNLIIDAPSAVTALCCHPNHPSELWDVLVAGGLYNGEVVVWNTSQ--TQDPVW-AQTGMSSDSHREPVYQVAWVPLQKKGDFGILSACSGGRVLLWLVDSYRTRLVLNDGYALAKQQIPHSISGRGSNTVGV-TSLALSPWDSDTFLVGS-EGGLQLKCSFSSRMLAAVPSEGLSVALKAPAVFAFRPHSGPVYSLHCSPFHRNLFVSAGTDGLAHIHSLLQADPLLSLRVSDSYVFQVQWSPTRPLVFAAASGQGDVQIFDLGRRSLRPAASIQDGGADH--AATCLDFNRHRPRVL 465          

Query:   35 MPLKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 1975
            MPLKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR
Sbjct:    1 MPLKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNKYELNCQDIVALRQINLPIDMETVADRFLESGTCIALHPKKYHTFLVGTQDGNIYYHLTMNSNMKSNSDYSMTFNENIHKMIIYQLVWSNWHPDIFASCSADWTIGIWNCRQSNPLFVLDLGFAVTSIAWAPYSSTVLAAVTVDRKVRVYDFSINRLEPLVCQVVGSSKHKVSLTQIVFSDNYPIILIGDSR 647          

Query:   41 LKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNK 1402
            +K  + +K+      + ++D     P  +  +  +  +VKP DQ+ LTEQEL+EE T++L ATNP AP NIV++NFKEM YKP+  +D   +HFS++ NL+++DS E    ++    L D+          +      E E   + SQ  T  + E       +   K +NQF +C RA+QT NNP + +   +E PPR  FSDN+ Q VIYD+Y  DF++Q + +K +   FG   K+    KK+++ + E    +++ I   +KI+ERM+N NTFDEI+QDF YYEDP+DE+R D  GTLLPLW+F+FDK +K+ VT++ WS  Y DLF V HG Y+ +  +  G IC Y+LKNPSYPEY   T+S VL++D++ +   ++C G  DG V + ++ ++ S    +   S   + KH DP W+VKW   + DN + FYS+S+DGR+  W++ K
Sbjct:    1 MKGAKDKKTKGRRRSKIEEDIPEAGPQDDLGDFMHSKIVKPEDQMQLTEQELKEEFTRILTATNPHAPQNIVRFNFKEMCYKPIAQVDQLAVHFSVEGNLLHRDSDEGRRQMAKQGKLIDD-------LKEDKEPGEGETETEDLSSQKETPVEPE-------VSEKKLTNQFNFCERASQTYNNPARDRGNVTEPPPRSNFSDNITQWVIYDAYLEDFEKQQQ-SKEKKATFG--TKVEEKSKKKLTSI-ETAADEMSKIAKPIKIVERMVNQNTFDEISQDFKYYEDPSDEYR-DQQGTLLPLWRFTFDKAKKIAVTALSWSPKYHDLFAVGHGSYDFMK-QSNGLICFYTLKNPSYPEYIFETQSGVLSLDLHRSLPHMLCVGFYDGAVGVYNITQRKSGPLYL---STAQTGKHTDPVWEVKWQREDFDNNLNFYSVSADGRVTSWTLIK 431          

Query:  143 YQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNK 1402
            +  +VKP DQ+ LTEQEL+EE T++L ATNP AP NIV++NFKEM YKP+  +D   +HFS++ NL+++DS E    ++    L D+          +      E E   + SQ  T  + E       +   K +NQF +C RA+QT NNP + +   +E PPR  FSDN+ Q VIYD+Y  DF++Q + +K +   FG   K+    KK+++ + E    +++ I   +KI+ERM+N NTFDEI+QDF YYEDP+DE+R D  GTLLPLW+F+FDK +K+ VT++ WS  Y DLF V HG Y+ +  +  G IC Y+LKNPSYPEY   T+S VL++D++ +   ++C G  DG V + ++ ++ S    +   S   + KH DP W+VKW   + DN + FYS+S+DGR+  W++ K
Sbjct:   57 HSKIVKPEDQMQLTEQELKEEFTRILTATNPHAPQNIVRFNFKEMCYKPIAQVDQLAVHFSVEGNLLHRDSDEGRRQMAKQGKLIDD-------LKEDKEPGEGETETEDLSSQKETPVEPE-------VSEKKLTNQFNFCERASQTYNNPARDRGNVTEPPPRSNFSDNITQWVIYDAYLEDFEKQQQ-SKEKKATFG--TKVEEKSKKKLTSI-ETAADEMSKIAKPIKIVERMVNQNTFDEISQDFKYYEDPSDEYR-DQQGTLLPLWRFTFDKAKKIAVTALSWSPKYHDLFAVGHGSYDFMK-QSNGLICFYTLKNPSYPEYIFETQSGVLSLDLHRSLPHMLCVGFYDGAVGVYNITQRKSGPLYL---STAQTGKHTDPVWEVKWQREDFDNNLNFYSVSADGRVTSWTLIK 453          

Query:  434 NIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHGMYEIVSFEEQGAICGYSLKNPSYPEYTLFTKSPVLAIDMNINDHRLICAGLLDGGVMIISLHEKSSSNPVIRLSSNMHSKKHRDPCWQVKWLPIEKDNIMAFYSISSDGRICEWSVNK 1402
            NIV  N + E+  + SQ  T  + E       +   K +NQF +C RA+QT NNP + +   +E PPR  FSDN+ Q VIYD+Y  DF++Q + +K +   FG   K+    KK+++ + E    +++ I   +KI+ERM+N NTFDEI+QDF YYEDP+DE+R D  GTLLPLW+F+FDK +K+ VT++ WS  Y DLF V HG Y+ +  +  G IC Y+LKNPSYPEY   T+S VL++D++ +   ++C G  DG V + ++ ++ S    +   S   + KH DP W+VKW   + DN + FYS+S+DGR+  W++ K
Sbjct:   70 NIVRFNFKTED--LSSQKETPVEPE-------VSEKKLTNQFNFCERASQTYNNPARDRGNVTEPPPRSNFSDNITQWVIYDAYLEDFEKQQQ-SKEKKATFG--TKVEEKSKKKLTSI-ETAADEMSKIAKPIKIVERMVNQNTFDEISQDFKYYEDPSDEYR-DQQGTLLPLWRFTFDKAKKIAVTALSWSPKYHDLFAVGHGSYDFMK-QSNGLICFYTLKNPSYPEYIFETQSGVLSLDLHRSLPHMLCVGFYDGAVGVYNITQRKSGPLYL---STAQTGKHTDPVWEVKWQREDFDNNLNFYSVSADGRVTSWTLIK 374          

Query:   41 LKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFK 271
            +K  + +K+      + ++D     P  +  +  +  +VKP DQ+ LTEQEL+EE T++L ATNP AP NIV++NFK
Sbjct:    1 MKGAKDKKTKGRRRSKIEEDIPEAGPQDDLGDFMHSKIVKPEDQMQLTEQELKEEFTRILTATNPHAPQNIVRFNFK 77          

Query:   41 LKPFEKRKSNAFYLKRKDDDFYTKDPTLNENEDHYQTLVKPPDQLNLTEQELREEITKVLKATNPAAPDNIVKYNFKEMQYKPVPYIDHTTIHFSMDSNLVYKDSMEAVSNLSVPAFLDDNSVHLPIEFDANIVLENLEQENSTMLSQTSTTFKQEAWNENSNLDSNKSSNQFLYCHRATQTLNNPLQTKITQSEYPPRKMFSDNLDQSVIYDSYEIDFKRQNRINKSRLTNFGGSQKIIVPDKKRISLVHEKHFGDITPILPVVKILERMINLNTFDEIAQDFSYYEDPADEFRFDSHGTLLPLWKFSFDKTRKLPVTSIIWSSFYKDLFVVSHG 1048
            +K  + +K+      + ++D     P  +  +  +  +VKP DQ+ LTEQEL+EE T++L ATNP AP NIV++NFKEM YKP+  +D   +HFS++ NL+++DS E    ++    L D+          +      E E   + SQ  T  + E       +   K +NQF +C RA+QT NNP + +   +E PPR  FSDN+ Q VIYD+Y  DF                                EK   +++ I   +KI+ERM+N NTFDEI+QDF YYEDP+DE+R D  GTLLPLW+F+FDK +K+ VT++ WS  Y DLF V HG
Sbjct:    1 MKGAKDKKTKGRRRSKIEEDIPEAGPQDDLGDFMHSKIVKPEDQMQLTEQELKEEFTRILTATNPHAPQNIVRFNFKEMCYKPIAQVDQLAVHFSVEGNLLHRDSDEGRRQMAKQGKLIDD-------LKEDKEPGEGETETEDLSSQKETPVEPE-------VSEKKLTNQFNFCERASQTYNNPARDRGNVTEPPPRSNFSDNITQWVIYDAYLEDF--------------------------------EKQADEMSKIAKPIKIVERMVNQNTFDEISQDFKYYEDPSDEYR-DQQGTLLPLWRFTFDKAKKIAVTALSWSPKYHDLFAVGHG 289