Mitochondrial pyruvate carrier

Overview
NameMitochondrial pyruvate carrier
Smed IDSMED30018763
Length (bp)712
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Mitochondrial pyruvate carrier (SMED30018763) t-SNE clustered cells

Violin plots show distribution of expression levels for Mitochondrial pyruvate carrier (SMED30018763) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Mitochondrial pyruvate carrier (SMED30018763) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Mitochondrial pyruvate carrier (SMED30018763) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30018763

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 14

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30018763SMESG000080319.1 SMESG000080318.1 Contig4429GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30018763SMESG000004344.1 Contig4429GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
protonephridiaSMED30018763SMESG000004344.1 dd_Smed_v4_8071_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30018763SMESG000004344.1 dd_Smed_v4_8071_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30018763SMESG000004344.1 dd_Smed_v4_8071_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30018763SMESG000004344.1 dd_Smed_v4_8071_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig10563newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig10563uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig22972newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig22972uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000080319.1 SMESG000080318.1 Contig4429GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig51046newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig51046uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018763SMESG000004344.1 Contig4429GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Human
Match: MPC2 (mitochondrial pyruvate carrier 2 [Source:HGNC Symbol;Acc:HGNC:24515])

HSP 1 Score: 135.576 bits (340), Expect = 5.680e-40
Identity = 62/110 (56.36%), Postives = 80/110 (72.73%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y  L+ K + ++P+K  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:   13 YHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELK 122
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Human
Match: MPC2 (mitochondrial pyruvate carrier 2 [Source:HGNC Symbol;Acc:HGNC:24515])

HSP 1 Score: 135.576 bits (340), Expect = 5.680e-40
Identity = 62/110 (56.36%), Postives = 80/110 (72.73%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y  L+ K + ++P+K  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:   13 YHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELK 122
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Human
Match: MPC2 (mitochondrial pyruvate carrier 2 [Source:HGNC Symbol;Acc:HGNC:24515])

HSP 1 Score: 124.02 bits (310), Expect = 7.371e-36
Identity = 56/92 (60.87%), Postives = 71/92 (77.17%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVA 299
            Y  L+ K + ++P+K  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV 
Sbjct:   13 YHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVG 104
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Celegans
Match: mpc-2 (Probable mitochondrial pyruvate carrier 2 [Source:UniProtKB/Swiss-Prot;Acc:O01578])

HSP 1 Score: 127.872 bits (320), Expect = 2.731e-37
Identity = 65/111 (58.56%), Postives = 75/111 (67.57%), Query Frame = 3 
Query:   21 IYRNLITKADKLV----PKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQ 341
            +Y+ L    DK V    P    P WNH+AGPKT+FFWAPT KWTL+ AGLAD+ARPADKLSL Q+ AL  TG IW+RY LVI P N  L SVN FV  TG  Q+ RI  Y+
Sbjct:    7 LYQALCKAGDKFVYPVLPAFAKPAWNHAAGPKTVFFWAPTIKWTLIGAGLADLARPADKLSLYQNSALFATGAIWTRYCLVITPINYYLSSVNFFVMCTGLAQLCRIAHYR 117
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Match: CG9399 (gene:FBgn0037715 transcript:FBtr0082110)

HSP 1 Score: 145.591 bits (366), Expect = 5.850e-44
Identity = 66/109 (60.55%), Postives = 82/109 (75.23%), Query Frame = 3 
Query:   21 IYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            +Y  +I  ADK VP K  P+W H AGPKTIFFWAP FKW LV AGL+D+ARPAD +S+S   ALA TG IWSRYSLVIIP+N +LF+VN+FV +T  +Q+ R + Y +S
Sbjct:   31 LYNGMIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQS 139
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Match: CG9399 (gene:FBgn0037715 transcript:FBtr0082109)

HSP 1 Score: 145.591 bits (366), Expect = 5.850e-44
Identity = 66/109 (60.55%), Postives = 82/109 (75.23%), Query Frame = 3 
Query:   21 IYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            +Y  +I  ADK VP K  P+W H AGPKTIFFWAP FKW LV AGL+D+ARPAD +S+S   ALA TG IWSRYSLVIIP+N +LF+VN+FV +T  +Q+ R + Y +S
Sbjct:   31 LYNGMIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQS 139
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Match: CG9399 (gene:FBgn0037715 transcript:FBtr0334656)

HSP 1 Score: 145.591 bits (366), Expect = 5.850e-44
Identity = 66/109 (60.55%), Postives = 82/109 (75.23%), Query Frame = 3 
Query:   21 IYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            +Y  +I  ADK VP K  P+W H AGPKTIFFWAP FKW LV AGL+D+ARPAD +S+S   ALA TG IWSRYSLVIIP+N +LF+VN+FV +T  +Q+ R + Y +S
Sbjct:   31 LYNGMIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQS 139
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Match: CG9399 (gene:FBgn0037715 transcript:FBtr0334657)

HSP 1 Score: 141.739 bits (356), Expect = 8.353e-43
Identity = 65/105 (61.90%), Postives = 80/105 (76.19%), Query Frame = 3 
Query:   33 LITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            +I  ADK VP K  P+W H AGPKTIFFWAP FKW LV AGL+D+ARPAD +S+S   ALA TG IWSRYSLVIIP+N +LF+VN+FV +T  +Q+ R + Y +S
Sbjct:    1 MIGAADKFVPAKLRPLWMHPAGPKTIFFWAPVFKWGLVAAGLSDLARPADTISVSGCAALAATGIIWSRYSLVIIPKNYSLFAVNLFVGITQVVQLARAYHYHQS 105
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Match: CG9396 (gene:FBgn0037714 transcript:FBtr0082111)

HSP 1 Score: 132.494 bits (332), Expect = 9.129e-39
Identity = 62/106 (58.49%), Postives = 77/106 (72.64%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQ 341
            Y  LI   DK VP K  P+W H AGPKTIFFWAP  KW+LV+AGL+D+ RPADK+S +   AL  T  IW+RYSLVIIP+N +LF+VN+FV+LT   Q+ R + YQ
Sbjct:   26 YNGLIKACDKYVPPKMRPLWMHPAGPKTIFFWAPIVKWSLVIAGLSDLTRPADKISPNGCLALGATNLIWTRYSLVIIPKNYSLFAVNLFVSLTQLFQLGRYYNYQ 131
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Zebrafish
Match: mpc2 (mitochondrial pyruvate carrier 2 [Source:ZFIN;Acc:ZDB-GENE-030131-330])

HSP 1 Score: 138.272 bits (347), Expect = 2.380e-41
Identity = 62/108 (57.41%), Postives = 80/108 (74.07%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            Y  ++ + + ++P K  P +NH AGPKT+FFWAP FKW LV+AGLAD+ARPA+KLS SQS  L  TG IWSRYSLVIIP+N NLF+VN FV   G  Q+ RI+++ + 
Sbjct:   10 YHRILDRMEHMLPAKLRPFYNHPAGPKTVFFWAPMFKWGLVLAGLADMARPAEKLSTSQSAVLTATGLIWSRYSLVIIPKNWNLFAVNFFVGSAGGSQLYRIWMHNRE 117
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Zebrafish
Match: zgc:103678 (zgc:103678 [Source:ZFIN;Acc:ZDB-GENE-040912-107])

HSP 1 Score: 131.339 bits (329), Expect = 2.287e-38
Identity = 59/119 (49.58%), Postives = 81/119 (68.07%), Query Frame = 3 
Query:    9 YMAGI---YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            Y  G+   Y   + + + ++P K  P++NH AGPKT+FFWAP FKW LV AG +D+ RP +KLS+SQS  +  TG IWSRY LVIIP+N  LF+VN F+ + G +Q+ RI+ Y + L Q
Sbjct:   18 YSGGVRATYHRTLDRIELMLPPKLRPVYNHPAGPKTVFFWAPVFKWGLVAAGFSDMTRPPEKLSVSQSCVITATGLIWSRYCLVIIPKNWALFAVNFFLGMCGSIQLFRIWRYNQELKQ 136
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:Xenbase;Acc:XB-GENE-990392])

HSP 1 Score: 131.724 bits (330), Expect = 1.445e-38
Identity = 60/110 (54.55%), Postives = 77/110 (70.00%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y   + + + ++P K  P++NH AGPKT+FFWAP  KW LV+AGLAD+ RPA+KLS  QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:   11 YHRALDRIEMMLPSKLRPLYNHPAGPKTVFFWAPIMKWGLVIAGLADMTRPAEKLSTGQSAVLTATGLIWSRYSLVIIPKNWSLFAVNFFVGCAGGSQLFRIWRYNQDLK 120
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Xenopus
Match: best1 (bestrophin 1 [Source:Xenbase;Acc:XB-GENE-990392])

HSP 1 Score: 72.0182 bits (175), Expect = 4.208e-16
Identity = 35/63 (55.56%), Postives = 43/63 (68.25%), Query Frame = 3 
Query:  165 IARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            + RPA+KLS  QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:    1 MTRPAEKLSTGQSAVLTATGLIWSRYSLVIIPKNWSLFAVNFFVGCAGGSQLFRIWRYNQDLK 63
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Mouse
Match: Mpc2 (mitochondrial pyruvate carrier 2 [Source:MGI Symbol;Acc:MGI:1917706])

HSP 1 Score: 121.709 bits (304), Expect = 9.306e-35
Identity = 64/109 (58.72%), Postives = 80/109 (73.39%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSL 350
            Y  L+ K + L+PKK  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L
Sbjct:   13 YHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQEL 121
[Close]
BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Match: sp|O95563|MPC2_HUMAN (Mitochondrial pyruvate carrier 2 OS=Homo sapiens OX=9606 GN=MPC2 PE=1 SV=1)

HSP 1 Score: 135.576 bits (340), Expect = 2.728e-39
Identity = 62/110 (56.36%), Postives = 80/110 (72.73%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y  L+ K + ++P+K  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:   13 YHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELK 122
[Close]
BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Match: sp|Q5R4Z3|MPC2_PONAB (Mitochondrial pyruvate carrier 2 OS=Pongo abelii OX=9601 GN=MPC2 PE=2 SV=1)

HSP 1 Score: 130.954 bits (328), Expect = 1.531e-37
Identity = 61/110 (55.45%), Postives = 79/110 (71.82%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y  L+ K + ++P+K  P++NH AGP+T+FFWAP  K  LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L 
Sbjct:   13 YHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKRGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELK 122
[Close]
BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Match: sp|O01578|MPC2_CAEEL (Probable mitochondrial pyruvate carrier 2 OS=Caenorhabditis elegans OX=6239 GN=mpc-2 PE=3 SV=2)

HSP 1 Score: 127.872 bits (320), Expect = 3.473e-36
Identity = 65/111 (58.56%), Postives = 75/111 (67.57%), Query Frame = 3 
Query:   21 IYRNLITKADKLV----PKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQ 341
            +Y+ L    DK V    P    P WNH+AGPKT+FFWAPT KWTL+ AGLAD+ARPADKLSL Q+ AL  TG IW+RY LVI P N  L SVN FV  TG  Q+ RI  Y+
Sbjct:    7 LYQALCKAGDKFVYPVLPAFAKPAWNHAAGPKTVFFWAPTIKWTLIGAGLADLARPADKLSLYQNSALFATGAIWTRYCLVITPINYYLSSVNFFVMCTGLAQLCRIAHYR 117
[Close]
BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Match: sp|Q9D023|MPC2_MOUSE (Mitochondrial pyruvate carrier 2 OS=Mus musculus OX=10090 GN=Mpc2 PE=1 SV=1)

HSP 1 Score: 121.709 bits (304), Expect = 6.510e-34
Identity = 64/109 (58.72%), Postives = 80/109 (73.39%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSL 350
            Y  L+ K + L+PKK  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L
Sbjct:   13 YHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWRYNQEL 121
[Close]
BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Match: sp|P38718|MPC2_RAT (Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus OX=10116 GN=Mpc2 PE=2 SV=1)

HSP 1 Score: 121.709 bits (304), Expect = 7.174e-34
Identity = 64/109 (58.72%), Postives = 80/109 (73.39%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSL 350
            Y  L+ K + L+PKK  P++NH AGP+T+FFWAP  KW LV AGLAD+ARPA+KLS +QS  L  TG IWSRYSLVIIP+N +LF+VN FV   G  Q+ RI+ Y + L
Sbjct:   13 YHRLMDKVELLLPKKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSTVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGSAGASQLFRIWKYNQEL 121
[Close]
BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Match: A0A1B0GIK1 (Mitochondrial pyruvate carrier OS=Lutzomyia longipalpis OX=7200 PE=3 SV=1)

HSP 1 Score: 170.629 bits (431), Expect = 1.410e-50
Identity = 73/115 (63.48%), Postives = 96/115 (83.48%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            M+ +YR +I+ ADK VP K +P+WNH AGPKT+FFWAP FKW LV+AGL+D+ARPAD+LS++QSG+L  TG IWSRYSLVIIP+N  LFSVN+FVAL+  +Q+ R ++YQ+ LN+
Sbjct:    3 MSSVYRGIISTADKFVPPKMMPLWNHPAGPKTVFFWAPVFKWGLVIAGLSDLARPADQLSVAQSGSLCATGIIWSRYSLVIIPKNWGLFSVNLFVALSSSVQLVRAYMYQQELNK 117
[Close]
BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Match: A0A1S3JV18 (Mitochondrial pyruvate carrier OS=Lingula unguis OX=7574 GN=LOC106176363 PE=3 SV=1)

HSP 1 Score: 167.548 bits (423), Expect = 1.528e-49
Identity = 76/115 (66.09%), Postives = 93/115 (80.87%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            M+ +YR  I   DK VP KF P WNH AGPKTIFFWAPTFKW LV+AGLAD+ARPA+KLS+ Q+GALA TG IWSRYS+VIIP+N NLFSVN+FVA+TG  Q+ +I+ Y++ L +
Sbjct:    1 MSALYRAGIRVLDKAVPAKFQPFWNHEAGPKTIFFWAPTFKWALVIAGLADVARPAEKLSVRQAGALAATGLIWSRYSMVIIPKNWNLFSVNIFVAITGIYQLQKIYFYRQELKK 115
[Close]
BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Match: A0A4D5S411 (Mitochondrial pyruvate carrier (Fragment) OS=Ixodes scapularis OX=6945 PE=3 SV=1)

HSP 1 Score: 167.933 bits (424), Expect = 2.252e-49
Identity = 78/111 (70.27%), Postives = 91/111 (81.98%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            YR L+  ADK VP KF P+W H AGPKT+FFWAP+FKW LVVAG+ D+ARPADKLS SQS ALA TG IWSRYS+VIIP+N NLFSVN+FVALTG  Q+ RIF +Q+SL +
Sbjct:   22 YRALVNTADKFVPGKFRPLWEHPAGPKTVFFWAPSFKWALVVAGIGDLARPADKLSASQSTALAATGIIWSRYSMVIIPKNYNLFSVNIFVALTGLYQLLRIFRHQQSLKE 132
[Close]
BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Match: A0A023FGM5 (Mitochondrial pyruvate carrier OS=Amblyomma cajennense OX=34607 PE=2 SV=1)

HSP 1 Score: 166.392 bits (420), Expect = 4.812e-49
Identity = 76/114 (66.67%), Postives = 92/114 (80.70%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            MA +YR L+T AD+ VP K  P+W H AGPKTIFFWAP+FKW LV+AG+ D+ARPA+KLS SQS ALA TG IWSRYS+VIIP+N NLFSVN+FVALTG  Q+ RI+ Y ++L 
Sbjct:    1 MAALYRVLVTTADRFVPSKLRPLWEHPAGPKTIFFWAPSFKWALVIAGIGDLARPAEKLSASQSTALAATGIIWSRYSMVIIPKNYNLFSVNIFVALTGLYQLLRIYRYNQTLK 114
[Close]
BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Match: A0A023FHE5 (Mitochondrial pyruvate carrier OS=Amblyomma cajennense OX=34607 PE=2 SV=1)

HSP 1 Score: 166.007 bits (419), Expect = 7.521e-49
Identity = 76/114 (66.67%), Postives = 92/114 (80.70%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            MA +YR L+T AD+ VP K  P+W H AGPKTIFFWAP+FKW LV+AG+ D+ARPA+KLS SQS ALA TG IWSRYS+VIIP+N NLFSVN+FVALTG  Q+ RI+ Y ++L 
Sbjct:    1 MAALYRVLVTTADRFVPSKLRPLWEHPAGPKTIFFWAPSFKWALVIAGIGDLARPAEKLSASQSTALAATGIIWSRYSMVIIPKNYNLFSVNIFVALTGLYQLFRIYRYNQTLK 114
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Cavefish
Match: mpc2 (mitochondrial pyruvate carrier 2 [Source:NCBI gene;Acc:103029922])

HSP 1 Score: 135.961 bits (341), Expect = 2.237e-40
Identity = 62/108 (57.41%), Postives = 80/108 (74.07%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            Y  ++ + + ++P K  P++NH AGPKT+FFWAP FKW LV+AGLAD+ RPA+KLS SQS  L  TG IWSRYSLVIIP+N NLF+VN FV   G  Q+ RI+ Y++ 
Sbjct:   10 YHRVLDRIEHILPAKLRPLYNHPAGPKTVFFWAPMFKWGLVMAGLADMTRPAEKLSTSQSAVLTATGLIWSRYSLVIIPKNWNLFAVNFFVGGAGGSQLFRIWQYKQD 117
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Cavefish
Match: zgc:103678 (mitochondrial pyruvate carrier 2-like [Source:NCBI gene;Acc:103033906])

HSP 1 Score: 130.954 bits (328), Expect = 1.886e-38
Identity = 57/115 (49.57%), Postives = 79/115 (68.70%), Query Frame = 3 
Query:    9 YMAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y+   Y   + + + ++P +  P++NH AGPKT+FFWAP FKW LV AG +D+ RP +KLSLSQS  +  TG IWSRY LVIIP+N  LF+VN F+ + G +Q+ RI+ Y + L 
Sbjct:    7 YLRAAYHRTLDRVELMLPPRLRPLYNHPAGPKTVFFWAPVFKWGLVFAGFSDMTRPPEKLSLSQSCVITATGFIWSRYCLVIIPKNWALFAVNFFLGMCGTIQLFRIWRYNQELK 121
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Cavefish
Match: zgc:103678 (mitochondrial pyruvate carrier 2-like [Source:NCBI gene;Acc:103033906])

HSP 1 Score: 128.642 bits (322), Expect = 2.200e-37
Identity = 56/110 (50.91%), Postives = 77/110 (70.00%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLN 353
            Y   + + + ++P +  P++NH AGPKT+FFWAP FKW LV AG +D+ RP +KLSLSQS  +  TG IWSRY LVIIP+N  LF+VN F+ + G +Q+ RI+ Y + L 
Sbjct:   24 YHRTLDRVELMLPPRLRPLYNHPAGPKTVFFWAPVFKWGLVFAGFSDMTRPPEKLSLSQSCVITATGFIWSRYCLVIIPKNWALFAVNFFLGMCGTIQLFRIWRYNQELK 133
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Cavefish
Match: zgc:103678 (mitochondrial pyruvate carrier 2-like [Source:NCBI gene;Acc:103033906])

HSP 1 Score: 124.02 bits (310), Expect = 1.324e-35
Identity = 55/119 (46.22%), Postives = 83/119 (69.75%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRI--FLYQKSLNQ*INDKI 374
            Y   + + + ++P +  P++NH AGPKT+FFWAP FKW LV AG +D+ RP +KLSLSQS  +  TG IWSRY LVIIP+N  LF+VN F+ + G +Q+ RI  ++++ ++   + D++
Sbjct:   24 YHRTLDRVELMLPPRLRPLYNHPAGPKTVFFWAPVFKWGLVFAGFSDMTRPPEKLSLSQSCVITATGFIWSRYCLVIIPKNWALFAVNFFLGMCGTIQLFRIWRWVFRNTVTDAVCDEM 142
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Sea Lamprey
Match: mpc2 (mitochondrial pyruvate carrier 2 [Source:ZFIN;Acc:ZDB-GENE-030131-330])

HSP 1 Score: 133.65 bits (335), Expect = 2.477e-40
Identity = 59/108 (54.63%), Postives = 80/108 (74.07%), Query Frame = 3 
Query:    9 YMAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIF 332
            + AG +R +  + + ++P+KF PIW H AGPKT+FFW PT KW LV AG+AD+ARPA+KLSL Q+  L ++G +WSRYS VIIP+N+N+F VN F+   G  Q+ RIF
Sbjct:    7 FRAGFHRTM-DRIELILPQKFRPIWRHPAGPKTVFFWGPTVKWGLVFAGMADMARPAEKLSLYQNSVLGLSGFLWSRYSFVIIPKNINMFCVNFFLGCCGTGQLIRIF 113
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Yeast
Match: MPC2 (Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on fermentable carbon sources, and heterodimerizes with Mpc1p to form the fermentative isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC2 paralog, MPC3, heterodimerizes with Mpc1p to form the respiratory MPC isoform [Source:SGD;Acc:S000001205])

HSP 1 Score: 92.4337 bits (228), Expect = 1.736e-24
Identity = 45/91 (49.45%), Postives = 59/91 (64.84%), Query Frame = 3 
Query:   69 FLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQ 341
            F   W    GPKT+ FWAPT KW LV AG +D+ RP +K+S +Q+ +L  T  IW+R+S VI PRN+ L SVN F+ LT   Q+ RI  Y+
Sbjct:   10 FRRFWQSETGPKTVHFWAPTLKWGLVFAGFSDMKRPVEKISGAQNLSLLSTALIWTRWSFVIKPRNILLASVNSFLCLTAGYQLGRIANYR 100
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Yeast
Match: MPC3 (Highly conserved subunit of the mitochondrial pyruvate carrier (MPC); expressed during growth on nonfermentable carbon sources, and heterodimerizes with Mpc1p to form the respiratory isoform of MPC; MPC localizes to the mitochondrial inner membrane and mediates pyruvate uptake; MPC3 paralog, MPC2, heterodimerizes with Mpc1p to form the fermentative MPC isoform; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000003475])

HSP 1 Score: 91.6633 bits (226), Expect = 6.253e-24
Identity = 45/87 (51.72%), Postives = 56/87 (64.37%), Query Frame = 3 
Query:   69 FLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRI 329
            F   WN   GPKT+ FWAPT KW LV AGL DI RP +K+S +Q+ +L  T  IW+R+S VI P+N  L SVN F+  T    +TRI
Sbjct:   10 FRRFWNSETGPKTVHFWAPTLKWGLVFAGLNDIKRPVEKVSGAQNLSLLATALIWTRWSFVIKPKNYLLASVNFFLGCTAGYHLTRI 96
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Nematostella
Match: EDO33873 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SQZ7])

HSP 1 Score: 131.724 bits (330), Expect = 1.663e-39
Identity = 62/106 (58.49%), Postives = 80/106 (75.47%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRI 329
            M+ ++   + + + ++P + +P WN  AGPKTIFFWAP FKW LV AGLAD+ARPADKLS SQS ALA TG IW+RYS+VIIP+N  LFSVN+ + +TG  Q+ RI
Sbjct:    1 MSAVWTRFLGRIEAVLPSRMVPFWNAPAGPKTIFFWAPAFKWGLVFAGLADLARPADKLSPSQSTALAATGLIWARYSMVIIPKNWLLFSVNIGLGITGINQLARI 106
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Medaka
Match: mpc2 (mitochondrial pyruvate carrier 2 [Source:NCBI gene;Acc:101172615])

HSP 1 Score: 135.961 bits (341), Expect = 1.889e-40
Identity = 62/108 (57.41%), Postives = 80/108 (74.07%), Query Frame = 3 
Query:   24 YRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKS 347
            Y  ++ + + L+P K  P++NH AGPKT+FFWAP FKW LV AG+AD+ RPA+KLSLSQS  L  TG +WSRYSLVIIP+N NLF+VN FV   G  Q+ RI+ Y++ 
Sbjct:    9 YHRILDRIEVLLPAKLRPLYNHPAGPKTVFFWAPMFKWGLVFAGMADMTRPAEKLSLSQSCVLTATGLVWSRYSLVIIPKNWNLFAVNFFVGGAGASQLYRIWRYKQD 116
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Planmine SMEST
Match: SMESG000004344.1 (SMESG000004344.1)

HSP 1 Score: 233.032 bits (593), Expect = 6.799e-79
Identity = 114/115 (99.13%), Postives = 115/115 (100.00%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIP+NLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ
Sbjct:    1 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPKNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 115
[Close]
BLAST of Mitochondrial pyruvate carrier vs. Planmine SMEST
Match: SMESG000056663.1 (SMESG000056663.1)

HSP 1 Score: 175.252 bits (443), Expect = 3.664e-56
Identity = 82/115 (71.30%), Postives = 96/115 (83.48%), Query Frame = 3 
Query:   12 MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLADIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGYMQVTRIFLYQKSLNQ 356
            MA IY+++I+  DK +PKKF P W H AGPKTIFFWAPTFKW+LV+AGLADIARPADKLSLSQS ALA TG IWSRYS+VI P+N NLFSVN+FVA TG  Q+TRI  Y++SL +
Sbjct:    1 MALIYKSIISSLDKCIPKKFQPFWQHPAGPKTIFFWAPTFKWSLVIAGLADIARPADKLSLSQSSALAATGLIWSRYSMVITPKNYNLFSVNVFVAATGLYQITRIIRYRQSLKK 115
The following BLAST results are available for this feature:
BLAST of Mitochondrial pyruvate carrier vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 3
Match NameE-valueIdentityDescription
MPC25.680e-4056.36mitochondrial pyruvate carrier 2 [Source:HGNC Symb... [more]
MPC25.680e-4056.36mitochondrial pyruvate carrier 2 [Source:HGNC Symb... [more]
MPC27.371e-3660.87mitochondrial pyruvate carrier 2 [Source:HGNC Symb... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mpc-22.731e-3758.56Probable mitochondrial pyruvate carrier 2 [Source... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CG93995.850e-4460.55gene:FBgn0037715 transcript:FBtr0082110[more]
CG93995.850e-4460.55gene:FBgn0037715 transcript:FBtr0082109[more]
CG93995.850e-4460.55gene:FBgn0037715 transcript:FBtr0334656[more]
CG93998.353e-4361.90gene:FBgn0037715 transcript:FBtr0334657[more]
CG93969.129e-3958.49gene:FBgn0037714 transcript:FBtr0082111[more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
mpc22.380e-4157.41mitochondrial pyruvate carrier 2 [Source:ZFIN;Acc:... [more]
zgc:1036782.287e-3849.58zgc:103678 [Source:ZFIN;Acc:ZDB-GENE-040912-107][more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 2
Match NameE-valueIdentityDescription
best11.445e-3854.55bestrophin 1 [Source:Xenbase;Acc:XB-GENE-990392][more]
best14.208e-1655.56bestrophin 1 [Source:Xenbase;Acc:XB-GENE-990392][more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 1
Match NameE-valueIdentityDescription
Mpc29.306e-3558.72mitochondrial pyruvate carrier 2 [Source:MGI Symbo... [more]
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BLAST of Mitochondrial pyruvate carrier vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|O95563|MPC2_HUMAN2.728e-3956.36Mitochondrial pyruvate carrier 2 OS=Homo sapiens O... [more]
sp|Q5R4Z3|MPC2_PONAB1.531e-3755.45Mitochondrial pyruvate carrier 2 OS=Pongo abelii O... [more]
sp|O01578|MPC2_CAEEL3.473e-3658.56Probable mitochondrial pyruvate carrier 2 OS=Caeno... [more]
sp|Q9D023|MPC2_MOUSE6.510e-3458.72Mitochondrial pyruvate carrier 2 OS=Mus musculus O... [more]
sp|P38718|MPC2_RAT7.174e-3458.72Mitochondrial pyruvate carrier 2 OS=Rattus norvegi... [more]
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BLAST of Mitochondrial pyruvate carrier vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1B0GIK11.410e-5063.48Mitochondrial pyruvate carrier OS=Lutzomyia longip... [more]
A0A1S3JV181.528e-4966.09Mitochondrial pyruvate carrier OS=Lingula unguis O... [more]
A0A4D5S4112.252e-4970.27Mitochondrial pyruvate carrier (Fragment) OS=Ixode... [more]
A0A023FGM54.812e-4966.67Mitochondrial pyruvate carrier OS=Amblyomma cajenn... [more]
A0A023FHE57.521e-4966.67Mitochondrial pyruvate carrier OS=Amblyomma cajenn... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
mpc22.237e-4057.41mitochondrial pyruvate carrier 2 [Source:NCBI gene... [more]
zgc:1036781.886e-3849.57mitochondrial pyruvate carrier 2-like [Source:NCBI... [more]
zgc:1036782.200e-3750.91mitochondrial pyruvate carrier 2-like [Source:NCBI... [more]
zgc:1036781.324e-3546.22mitochondrial pyruvate carrier 2-like [Source:NCBI... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mpc22.477e-4054.63mitochondrial pyruvate carrier 2 [Source:ZFIN;Acc:... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 2
Match NameE-valueIdentityDescription
MPC21.736e-2449.45Highly conserved subunit of the mitochondrial pyru... [more]
MPC36.253e-2451.72Highly conserved subunit of the mitochondrial pyru... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO338731.663e-3958.49Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 1
Match NameE-valueIdentityDescription
mpc21.889e-4057.41mitochondrial pyruvate carrier 2 [Source:NCBI gene... [more]
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BLAST of Mitochondrial pyruvate carrier vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000004344.16.799e-7999.13SMESG000004344.1[more]
SMESG000056663.13.664e-5671.30SMESG000056663.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018763 ID=SMED30018763|Name=Mitochondrial pyruvate carrier|organism=Schmidtea mediterranea sexual|type=transcript|length=712bp
TTTCATAATACATGGCGGGAATTTATCGAAATCTTATAACGAAGGCTGAC
AAATTAGTTCCAAAGAAATTTTTACCAATTTGGAATCATTCAGCAGGCCC
AAAAACTATATTCTTTTGGGCTCCGACTTTCAAATGGACCTTAGTTGTTG
CCGGACTGGCTGATATTGCTAGACCTGCTGATAAATTAAGTTTATCACAA
AGTGGAGCGTTAGCTGTGACTGGAACGATTTGGTCTCGTTATTCTTTGGT
TATAATACCAAGAAATTTAAATTTATTTTCTGTTAATATGTTTGTAGCAT
TGACTGGTTACATGCAAGTAACACGAATATTTCTATATCAGAAATCTTTA
AATCAGTGAATAAATGACAAAATTTCCATTTGGAGATATTGAAAATGAAA
AATTGAATTTGACTTAATGAAACTTTATTCTATGAATAGTATTATTAAGA
TGCGGCGATTTAATATTAAATCTCAATTAAAATCGCTTTGTTTTTGATGA
TAATTTAAAATATAATTATTTGAGATGAACTATCATTTAAACTTTAGGAG
TGCTTTTCTTGTGTTTTTACCTTTGTAAAAATCTTTAAAATACAATTAGT
ATGAAATTTATGAAACAAGTACAAGTTGACAATTGATGTTTAACACTTGT
TTATAGAATAATTTTAATGTCGAAGGTCGATTTTTGTGACTGGAATTAAA
TGACAATCTATG
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protein sequence of SMED30018763-orf-1

>SMED30018763-orf-1 ID=SMED30018763-orf-1|Name=SMED30018763-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=116bp
MAGIYRNLITKADKLVPKKFLPIWNHSAGPKTIFFWAPTFKWTLVVAGLA
DIARPADKLSLSQSGALAVTGTIWSRYSLVIIPRNLNLFSVNMFVALTGY
MQVTRIFLYQKSLNQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR005336MPC
Vocabulary: biological process
TermDefinition
GO:0006850mitochondrial pyruvate transport
GO:0006810transport
Vocabulary: cellular component
TermDefinition
GO:0005743mitochondrial inner membrane
GO:0005739mitochondrion
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR005336Mitochondrial pyruvate carrierPFAMPF03650MPCcoord: 22..112
e-value: 1.5E-38
score: 131.3
NoneNo IPR availablePANTHERPTHR14154UPF0041 BRAIN PROTEIN 44-RELATEDcoord: 14..113
NoneNo IPR availablePANTHERPTHR14154:SF2MITOCHONDRIAL PYRUVATE CARRIER 2coord: 14..113
NoneNo IPR availableTMHMMTMhelixcoord: 86..108