SOCS box domain-containing protein

Overview
NameSOCS box domain-containing protein
Smed IDSMED30018730
Length (bp)1787
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of SOCS box domain-containing protein (SMED30018730) t-SNE clustered cells

Violin plots show distribution of expression levels for SOCS box domain-containing protein (SMED30018730) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of SOCS box domain-containing protein (SMED30018730) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for SOCS box domain-containing protein (SMED30018730) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30018730

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
pharynxSMED30018730h1SMcG0006301 dd_Smed_v4_9937_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
nervous systemSMED30018730h1SMcG0006301 dd_Smed_v4_9937_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
head regionSMED30018730h1SMcG0006301 OX_Smed_1.0.19945ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
head regionSMED30018730h1SMcG0018649 OX_Smed_1.0.19945ox_Smed_v2PMID:24238224
Kao et al., 2013
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of SOCS box domain-containing protein vs. TrEMBL
Match: A0A5J4NQP0 (Uncharacterized protein OS=Paragonimus westermani OX=34504 GN=DEA37_0002227 PE=4 SV=1)

HSP 1 Score: 274.633 bits (701), Expect = 4.085e-81
Identity = 163/422 (38.63%), Postives = 245/422 (58.06%), Query Frame = 2
Query:  278 KIEDALIQIIRNGDFESLIKIFER-GYSLKDICVTVYRKNLQHLCNCWLDHNSK--DSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNL---YSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXX----XXXXXLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            + ++ L+++I+ G+  ++ +   R G  L ++ + V R++L     C +DH +   D  + FYQE SP++WAVDC QW +L  + + G + N+P  CRRWT +    S+ N  PY + WT+G+ TYQS LDY+ AS+YE + + P+ +                  LL  GVDVHRIDS+I+FN LA S+D  + RY+ NEH  V +           P  D  F E+     L+ENGFSQ + ++YL PC NWFGIL+C+L HP ID+              +PS+I+ AALLLINLL+++    PT  EF ++ +NL+LRK   K+++++R VF  R+  L R+C E  S+PL LK L R  +RK++GG+ F  KL  + LP +L  F+ +I   HLK++  P  LI +A G   +  +D
Sbjct:   27 ETDEKLVRLIQKGNLTTIERALRRIGRPLNEVTLIVKRRHLSTAYPCLVDHRAAGTDPFINFYQECSPVIWAVDCLQWQVLPLLARYGCDINRPQTCRRWTYICAPSSRPNTAPYRRFWTRGRYTYQSALDYFFASVYEFVGEQPSSYNGLCGPSPLTFYFSHLPALLSKGVDVHRIDSVIVFNSLATSYDQYLCRYT-NEHATVPD----------IPENDDAFVEMTAMKRLVENGFSQFECMDYLYPCCNWFGILLCILCHPKIDTYGNN---------LLPSIIRQAALLLINLLSLKCTV-PTVDEFGESLENLHLRKVYSKRYVERRDVFNCRLASLHRICQEMLSQPLCLKILTRNAVRKQIGGIDFCRKLSFVGLPPQLNSFVQFIGQEHLKASHMPKQLIRLAQGEWVDVTID 427          
BLAST of SOCS box domain-containing protein vs. TrEMBL
Match: A0A3S5FEP7 (Uncharacterized protein (Fragment) OS=Protopolystoma xenopodis OX=117903 GN=PXEA_LOCUS20188 PE=4 SV=1)

HSP 1 Score: 264.233 bits (674), Expect = 1.759e-78
Identity = 155/412 (37.62%), Postives = 227/412 (55.10%), Query Frame = 2
Query:  293 LIQIIRNGDFESLIKIFER--GYSLKDICVTVYRKNLQHLCNCWLDHNS--KDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVN----VVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXX----XXXXXLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGN 1492
            L  +I+ G+   + ++ +R    S  ++ + V R++L     C +DH S   D  + FYQ+ SP+LWAVDC QW +L  +   G++ N+P  C RWT      N       Y + W +G+ TYQS LDY+ ASIYE++ + P  +                  +L  GVDVHRIDS+I+FN LA+S+D  + RY+ NEH  V +           P  +  + E+     LIENGFSQ + +EY  PC NWFGILICLL HP I +  ++          +P +I+  ALLLIN LA+R  F P+  EF+D+ +NL+LRK   K++ ++R  F  R+  L+  C    ++P  L  LAR  +R++LGG  FL +L  L LP +L  F+ YI   HL+++  P  LI +A GN
Sbjct:   38 LAHLIQKGNLIGVERVLKRLPAQSRSNLSLVVRRRHLSTAYPCLVDHRSAGSDPFINFYQQCSPVLWAVDCLQWQVLPLLQHYGLDINRPQTCSRWTTYLCSPNCRSQTASYRRFWIRGRYTYQSALDYFFASIYELIGEQPATYNGLSGPSPLAFYFSHLPVILNKGVDVHRIDSVIVFNALASSYDQYLCRYT-NEHAIVPD----------IPENEDAYVEMTAVKRLIENGFSQFECMEYFYPCCNWFGILICLLCHPKICTFASR---------TLPPIIRQTALLLINFLALRYAF-PSPEEFKDSLENLHLRKVYSKRYSERREEFNHRLASLQAQCQALVAQPQTLTMLARNAVRRQLGGFHFLHRLASLGLPAKLTAFVQYIGQEHLRTSCMPKCLIRLAQGN 428          
BLAST of SOCS box domain-containing protein vs. TrEMBL
Match: A0A1S8XAM7 (SOCS box OS=Opisthorchis viverrini OX=6198 GN=X801_00321 PE=4 SV=1)

HSP 1 Score: 267.314 bits (682), Expect = 3.282e-78
Identity = 167/422 (39.57%), Postives = 240/422 (56.87%), Query Frame = 2
Query:  278 KIEDALIQIIRNGDFESL-IKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNS--KDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNL---YSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXXXXXXXLQS----GVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            + ++ L+++I+ G+   +   +      L ++ + V R++L     C +DH +   D  + FYQE SP+LWAVDC QW +L  +   G + N+P  CRRWT++    S+ N  PY + WT G+ TYQS LDY+ ASIYE L + P+ ++          +   L +    GVDVHRIDS+IIFN LAAS+D  + RY+ NE+  V +           P  D  F E+    +L+ENGFSQ + ++YL PC NWFGIL+CL+ HP IDS              +P +I+ AALLL NLL ++  F P+  EF +  +NL+LRK   K++ ++R  F  R+  L ++C     +PL LK LAR  +RK+LGGV F  KL  L LP +L  F+ YIN  HLK+ + P  LI +A G    Y LD
Sbjct:   27 EADEKLVRLIQKGNLPIIERALRRLRRPLNEVTLVVKRRHLSTAYPCLVDHRAAGSDPFINFYQECSPVLWAVDCLQWQVLPLLGHHGYDINRPQTCRRWTHICGPSSRPNSAPYRRFWTCGRYTYQSALDYFFASIYEFLGEQPSTYSGLSGPSPLAFYFSHLPAILTKGVDVHRIDSVIIFNSLAASYDEFLCRYT-NEYAIVPD----------IPENDDAFVEMTAVKHLVENGFSQFECMDYLYPCCNWFGILLCLICHPKIDSYGTN---------LLPPIIRHAALLLTNLLLLKCTF-PSAEEFSEALENLHLRKVYSKRYCERRDEFNRRLSNLHQVCQSMVLQPLSLKILARNAVRKQLGGVDFCRKLASLCLPPQLHSFVQYINQEHLKAIEMPKQLIRLAQGEWVEYSLD 427          
BLAST of SOCS box domain-containing protein vs. TrEMBL
Match: G7YB95 (SOCS box domain-containing protein OS=Clonorchis sinensis OX=79923 GN=CLF_104262 PE=4 SV=1)

HSP 1 Score: 266.159 bits (679), Expect = 7.310e-78
Identity = 167/422 (39.57%), Postives = 239/422 (56.64%), Query Frame = 2
Query:  278 KIEDALIQIIRNGDFESL-IKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNS--KDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNL---YSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXXXXXXXLQS----GVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            + ++ L+++I+ G+   +   +      L ++ + V R++L     C +DH +   D  + FYQE SP+LWAVDC QW +L  +   G + N+P  CRRWT++    S+ N  PY + WT G+ TYQS LDY+ ASIYE L + P+ +           +   L +    GVDVHRIDS+IIFN LAAS+D  + RY+ NE+  V +           P  D  F E+    +L+ENGFSQ + ++YL PC NWFGIL+CL+ HP IDS              +P +I+ AALLL NLL ++  F P+  EF +  +NL+LRK   K++ ++R  F  R+  L R+C     +PL LK LAR  +RK+LGG+ F  KL  L LP +L  F+ YIN  HLK+ + P  LI +A G    Y LD
Sbjct:   27 EADEKLVRLIQKGNLPIIERALRRLRRPLNEVTLVVKRRHLSTAYPCLVDHRAAGSDPFINFYQECSPVLWAVDCLQWQVLPLLGHHGYDINRPQTCRRWTHICGPSSRPNSAPYRRFWTCGRYTYQSALDYFFASIYEFLGEQPSTYNGLSGPSPLAFYFSHLPAILTKGVDVHRIDSVIIFNSLAASYDEFLCRYT-NEYAIVPD----------IPENDDAFVEMTAVKHLVENGFSQFECMDYLYPCCNWFGILLCLICHPKIDSYGTN---------LLPPIIRHAALLLTNLLLLKCTF-PSAEEFSEALENLHLRKVYSKRYCERRDEFNRRLSSLHRVCQSLVLQPLSLKILARNAVRKQLGGIDFCRKLASLCLPPQLHSFVQYINQEHLKAIEMPKQLIRLAQGEWVEYTLD 427          
BLAST of SOCS box domain-containing protein vs. TrEMBL
Match: A0A074ZX86 (SOCS box domain-containing protein OS=Opisthorchis viverrini OX=6198 GN=T265_03026 PE=4 SV=1)

HSP 1 Score: 266.159 bits (679), Expect = 9.614e-78
Identity = 167/422 (39.57%), Postives = 239/422 (56.64%), Query Frame = 2
Query:  278 KIEDALIQIIRNGDFESL-IKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNS--KDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNL---YSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXXXXXXXLQS----GVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            + ++ L+++I+ G+   +   +      L ++ + V R++L     C +DH +   D  + FYQE SP+LWAVDC QW +L  +   G + N+P  CRRWT++    S+ N  PY + WT G+ TYQS LDY+ ASIYE L + P+ +           +   L +    GVDVHRIDS+IIFN LAAS+D  + RY+ NE+  V +           P  D  F E+    +L+ENGFSQ + ++YL PC NWFGIL+CL+ HP IDS              +P +I+ AALLL NLL ++  F P+  EF +  +NL+LRK   K++ ++R  F  R+  L ++C     +PL LK LAR  +RK+LGGV F  KL  L LP +L  F+ YIN  HLK+ + P  LI +A G    Y LD
Sbjct:   27 EADEKLVRLIQKGNLPIIERALRRLRRPLNEVTLVVKRRHLSTAYPCLVDHRAAGSDPFINFYQECSPVLWAVDCLQWQVLPLLGHHGYDINRPQTCRRWTHICGPSSRPNSAPYRRFWTCGRYTYQSALDYFFASIYEFLGEQPSTYNGLSGPSPLAFYFSHLPAILTKGVDVHRIDSVIIFNSLAASYDEFLCRYT-NEYAIVPD----------IPENDDAFVEMTAVKHLVENGFSQFECMDYLYPCCNWFGILLCLICHPKIDSYGTN---------LLPPIIRHAALLLTNLLLLKCTF-PSAEEFSEALENLHLRKVYSKRYCERRDEFNRRLSNLHQVCQSMVLQPLSLKILARNAVRKQLGGVDFCRKLASLCLPPQLHSFVQYINQEHLKAIEMPKQLIRLAQGEWVEYSLD 427          
BLAST of SOCS box domain-containing protein vs. Planmine SMEST
Match: SMESG000001445.1 (SMESG000001445.1)

HSP 1 Score: 813.527 bits (2100), Expect = 0.000e+0
Identity = 440/440 (100.00%), Postives = 440/440 (100.00%), Query Frame = 2
Query:  194 MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXXXXXXXLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTLSDYSDYFDDFVDLLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFLSKLKRLELPRELEKFISYINVSHLKSTDFPNLLINMALGNHSNYQLD
Sbjct:    1 MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTLSDYSDYFDDFVDLLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFLSKLKRLELPRELEKFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 440          
BLAST of SOCS box domain-containing protein vs. Planmine SMEST
Match: SMESG000001437.1 (SMESG000001437.1)

HSP 1 Score: 813.527 bits (2100), Expect = 0.000e+0
Identity = 440/440 (100.00%), Postives = 440/440 (100.00%), Query Frame = 2
Query:  194 MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTXXXXXXXXXXXXXXLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFXXXXXXXXXXXXXXXFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 1513
            MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTLSDYSDYFDDFVDLLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFLSKLKRLELPRELEKFISYINVSHLKSTDFPNLLINMALGNHSNYQLD
Sbjct:    1 MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIFERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDCRQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQSVLDYYLASIYEILLDNPTQHTLSDYSDYFDDFVDLLQSGVDVHRIDSIIIFNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFINLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFEKIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQRIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFLSKLKRLELPRELEKFISYINVSHLKSTDFPNLLINMALGNHSNYQLD 440          
The following BLAST results are available for this feature:
BLAST of SOCS box domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A5J4NQP04.085e-8138.63Uncharacterized protein OS=Paragonimus westermani ... [more]
A0A3S5FEP71.759e-7837.62Uncharacterized protein (Fragment) OS=Protopolysto... [more]
A0A1S8XAM73.282e-7839.57SOCS box OS=Opisthorchis viverrini OX=6198 GN=X801... [more]
G7YB957.310e-7839.57SOCS box domain-containing protein OS=Clonorchis s... [more]
A0A074ZX869.614e-7839.57SOCS box domain-containing protein OS=Opisthorchis... [more]
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BLAST of SOCS box domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of SOCS box domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000001445.10.000e+0100.00SMESG000001445.1[more]
SMESG000001437.10.000e+0100.00SMESG000001437.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018730 ID=SMED30018730|Name=SOCS box domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=1787bp
TATAAATCTTATATGACATTTATAGACCTGATACTAACTTTCGTGTGCCA
TTCTGTATAAGCATCAGACTAGAGAAAAACCAACACACGCACACACACAC
ATTCACGCGTAGCATCTCGTTCACTGTATAGCCGTAGAAAGTATTCTTTA
TTTTTTATCGATTATTTTTAGAAATGATTGTTTTATTTTCTCAATGAATC
GAAAATTTATTTCCATTTTACTTTGTTGTTGGCCGGAAGACCTGTTCGAC
GGAAACAATGATATGTGGTCAAATAGGAAGATCGAAGATGCACTAATCCA
AATAATAAGAAATGGAGATTTTGAGTCGTTGATAAAAATTTTTGAACGCG
GTTATTCATTGAAAGACATTTGTGTAACGGTTTACAGGAAAAATCTACAG
CATTTATGCAATTGTTGGTTGGATCATAATTCGAAAGACAGTATCGTTTA
TTTTTATCAAGAAAGCAGTCCTCTACTGTGGGCAGTAGATTGTCGCCAAT
GGGATTTACTGAGAGCAATGATTAAGAGAGGCATGAACCCGAACAAGCCG
ATTGTTTGTCGGCGATGGACAAATTTGTATTCTAAGGTAAATGTGGTTCC
TTATACAAAATCTTGGACCAAAGGAAAATGTACGTATCAGTCAGTTTTAG
ATTATTATTTAGCGAGTATTTATGAAATCCTTTTGGACAATCCAACTCAA
CATACGCTTTCAGACTACAGCGATTATTTTGACGATTTTGTTGATCTTTT
ACAAAGCGGAGTTGATGTACATAGAATAGATTCGATTATTATTTTCAATT
TATTGGCTGCCAGTTTTGACATGGCTATTCGACGATACAGTTTGAATGAG
CACATCTGTGTTGTCAATCAAATAACAAGCATGCGAAATATTTCAACGAA
ACCGCTAAAAGACACAAAATTTACCGAAATCAAAGTTTTCATAAATCTAA
TTGAAAACGGGTTTTCTCAGCTGGATTTCATTGAATATCTAAATCCATGC
TATAATTGGTTCGGGATTTTAATCTGTTTACTAAGCCATCCAATGATCGA
CTCTAAAAACGCGAAACCCCAACAAAAATTCGATTGCTTTGAAAAAATTC
CATCTTTAATTAAAGATGCGGCTTTGCTGTTGATAAATCTGTTAGCTATG
AGAAACATTTTTTCACCGACATTCACAGAGTTCGAAGACAATTATGACAA
TTTGAATCTTAGAAAGAATTTGGTAAAGCAGTTCATTGATCAAAGAATTG
TATTTACTGAGAGAGTGGAAAAACTAAAACGCCTTTGTTCAGAGCAAAAA
TCTAAACCGTTGAAATTAAAATTTCTAGCTCGAACTGTAATTCGAAAACG
ATTGGGAGGGGTAAAATTTCTCTCGAAATTAAAACGACTGGAATTACCTA
GAGAATTGGAGAAATTCATTTCTTATATTAATGTTAGCCATTTAAAGTCA
ACCGACTTTCCAAATTTACTCATCAACATGGCTTTAGGAAATCACAGCAA
TTATCAACTTGACTGACTTTCAAATGTTATCAAAACAAATTTGTATATTT
TGTCAAAAATTTTTATTAATTTCCAAAACTTGTGATAATCATTGTTAGCA
AAATATCAAACTCTTTTAACGACATTATCTCTATTAAGAAAATCCTATTT
TTATTAAATAGATAAAACACTTCTTATATTTCCCAAATTACTAAATTTTG
TGAAGATTTTAAAAGGAACTTTATGATATTGATTTACATCTATTTGCTTC
TTGGCTTAATTGTATGTATATGATAACGTGTAAATAT
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protein sequence of SMED30018730-orf-1

>SMED30018730-orf-1 ID=SMED30018730-orf-1|Name=SMED30018730-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=441bp
MNRKFISILLCCWPEDLFDGNNDMWSNRKIEDALIQIIRNGDFESLIKIF
ERGYSLKDICVTVYRKNLQHLCNCWLDHNSKDSIVYFYQESSPLLWAVDC
RQWDLLRAMIKRGMNPNKPIVCRRWTNLYSKVNVVPYTKSWTKGKCTYQS
VLDYYLASIYEILLDNPTQHTLSDYSDYFDDFVDLLQSGVDVHRIDSIII
FNLLAASFDMAIRRYSLNEHICVVNQITSMRNISTKPLKDTKFTEIKVFI
NLIENGFSQLDFIEYLNPCYNWFGILICLLSHPMIDSKNAKPQQKFDCFE
KIPSLIKDAALLLINLLAMRNIFSPTFTEFEDNYDNLNLRKNLVKQFIDQ
RIVFTERVEKLKRLCSEQKSKPLKLKFLARTVIRKRLGGVKFLSKLKRLE
LPRELEKFISYINVSHLKSTDFPNLLINMALGNHSNYQLD*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000016pharynx
PLANA:0000099neuron
PLANA:0000418head
Vocabulary: INTERPRO
TermDefinition
IPR001496SOCS_box
Vocabulary: biological process
TermDefinition
GO:0035556intracellular signal transduction
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001496SOCS box domainPFAMPF07525SOCS_boxcoord: 372..411
e-value: 4.2E-6
score: 27.0
IPR001496SOCS box domainPROSITEPS50225SOCScoord: 362..415
score: 8.928