Kunitz-type serine protease inhibitor C4

Overview


Name	Kunitz-type serine protease inhibitor C4
Smed ID	SMED30018720
Length (bp)	329

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Kunitz-type serine protease inhibitor C4 (SMED30018720) t-SNE clustered cells

Violin plots show distribution of expression levels for Kunitz-type serine protease inhibitor C4 (SMED30018720) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Kunitz-type serine protease inhibitor C4 (SMED30018720) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Kunitz-type serine protease inhibitor C4 (SMED30018720) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30018720

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Expressed In	Reference Transcript	Published Transcript	Transcriptome	Publication
prepharyngeal region	SMED30018720	SmedASXL_002678	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parapharyngeal region	SMED30018720	SmedASXL_002678	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
parenchyma	SMED30018720	dd_Smed_v4_886_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parapharyngeal region	SMED30018720	dd_Smed_v6_886_0_1	dd_Smed_v6	PMID:28171748 Stückemann et al., 2017
head region	SMED30018720	OX_Smed_1.0.09545	ox_Smed_v2	PMID:24238224 Kao et al., 2013

Note: Hover over icons to view figure legend

Homology

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BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Human
Match: TFPI (tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760])

HSP 1 Score: 57.7658 bits (138), Expect = 1.095e-11
Identity = 24/56 (42.86%), Postives = 36/56 (64.29%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +S C     +G C+   + FFFN  + +CEE +YGGC GN+NRF ++EEC + C +
Sbjct:   51 HSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTR 106

[Close]

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +S C     +G C+   + FFFN  + +CEE +YGGC GN+NRF ++EEC + C +
Sbjct:   51 HSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTR 106

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Human
Match: TFPI (tissue factor pathway inhibitor [Source:HGNC Symbol;Acc:HGNC:11760])

HSP 1 Score: 57.3806 bits (137), Expect = 1.756e-11
Identity = 24/54 (44.44%), Postives = 35/54 (64.81%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S C     +G C+   + FFFN  + +CEE +YGGC GN+NRF ++EEC + C
Sbjct:   51 HSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMC 104

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Human
Match: COL6A3 (collagen type VI alpha 3 chain [Source:HGNC Symbol;Acc:HGNC:2213])

HSP 1 Score: 60.4622 bits (145), Expect = 1.887e-11
Identity = 21/56 (37.50%), Postives = 33/56 (58.93%), Query Frame = 1

Query:   73 SRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +   +C LPK EG CR +   ++++  +  C    YGGC GNEN+F + +EC + C
Sbjct: 2499 TETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVC 2554

[Close]

Query:   73 SRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +   +C LPK EG CR +   ++++  +  C    YGGC GNEN+F + +EC + C
Sbjct: 2500 TETDICKLPKDEGTCRDFILKWYYDPNTKSCARFWYGGCGGNENKFGSQKECEKVC 2555

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Celegans
Match: mig-6 (Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840])

HSP 1 Score: 65.0846 bits (157), Expect = 1.926e-13
Identity = 28/60 (46.67%), Postives = 37/60 (61.67%), Query Frame = 1

Query:   67 CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C++    C LPK +G C G    +++N  S +CE   YGGC GN NRF+TIEEC  +C K
Sbjct: 1497 CQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPK 1556

HSP 2 Score: 49.2914 bits (116), Expect = 6.469e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C   +  G C  Y + +F+N  S +CE   YGGC GN NRF + +EC ++C
Sbjct: 1265 QSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

HSP 3 Score: 47.7506 bits (112), Expect = 2.355e-7
Identity = 21/55 (38.18%), Postives = 28/55 (50.91%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NSVC   K  G C  +   +++NK  G C    YGGC G  NRF   ++C   C+
Sbjct: 1444 NSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ 1498

HSP 4 Score: 46.595 bits (109), Expect = 5.813e-7
Identity = 19/57 (33.33%), Postives = 32/57 (56.14%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +   C L   +G C+G F+++++   +G C    Y GC GN NRF++ ++C   C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 5 Score: 45.8246 bits (107), Expect = 1.181e-6
Identity = 18/53 (33.96%), Postives = 28/53 (52.83%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C L +  G C      ++F+     C+   YGGC GN+NRF + E+C + C+ 
Sbjct: 1853 CTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSCRP 1905

HSP 6 Score: 45.0542 bits (105), Expect = 1.811e-6
Identity = 20/54 (37.04%), Postives = 29/54 (53.70%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C+LP+Q G C      + F+ E  +C   +Y GCN N N F++ E C   C K
Sbjct: 1730 LCMLPEQRGSCYDNILRWRFDSEKSQCVTFMYSGCNPNANHFTSQETCERACGK 1783

HSP 7 Score: 43.8986 bits (102), Expect = 5.478e-6
Identity = 17/54 (31.48%), Postives = 32/54 (59.26%), Query Frame = 1

Query:   82 SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +VC LP + G C+     ++ + ++ +C+ M++ GC GN N FS+  +C   C+
Sbjct: 1788 AVCELPAEHGDCQLAIPRWYHDPKTSQCQMMMWTGCGGNGNAFSSKADCESLCR 1841

[Close]

Query:   67 CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C++    C LPK +G C G    +++N  S +CE   YGGC GN NRF+TIEEC  +C K
Sbjct: 1497 CQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCPK 1556

HSP 2 Score: 49.2914 bits (116), Expect = 6.469e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C   +  G C  Y + +F+N  S +CE   YGGC GN NRF + +EC ++C
Sbjct: 1265 QSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

HSP 3 Score: 47.7506 bits (112), Expect = 2.355e-7
Identity = 21/55 (38.18%), Postives = 28/55 (50.91%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NSVC   K  G C  +   +++NK  G C    YGGC G  NRF   ++C   C+
Sbjct: 1444 NSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ 1498

HSP 4 Score: 46.595 bits (109), Expect = 5.813e-7
Identity = 19/57 (33.33%), Postives = 32/57 (56.14%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +   C L   +G C+G F+++++   +G C    Y GC GN NRF++ ++C   C K
Sbjct: 1371 QRDACHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

HSP 5 Score: 45.8246 bits (107), Expect = 1.181e-6
Identity = 18/53 (33.96%), Postives = 28/53 (52.83%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C L +  G C      ++F+     C+   YGGC GN+NRF + E+C + C+ 
Sbjct: 1853 CTLERSAGPCTDSISMWYFDSTHLDCKPFTYGGCRGNQNRFVSKEQCQQSCRP 1905

HSP 6 Score: 45.0542 bits (105), Expect = 1.811e-6
Identity = 20/54 (37.04%), Postives = 29/54 (53.70%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C+LP+Q G C      + F+ E  +C   +Y GCN N N F++ E C   C K
Sbjct: 1730 LCMLPEQRGSCYDNILRWRFDSEKSQCVTFMYSGCNPNANHFTSQETCERACGK 1783

HSP 7 Score: 43.8986 bits (102), Expect = 5.478e-6
Identity = 17/54 (31.48%), Postives = 32/54 (59.26%), Query Frame = 1

Query:   82 SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +VC LP + G C+     ++ + ++ +C+ M++ GC GN N FS+  +C   C+
Sbjct: 1788 AVCELPAEHGDCQLAIPRWYHDPKTSQCQMMMWTGCGGNGNAFSSKADCESLCR 1841

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Celegans
Match: mig-6 (Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840])

HSP 1 Score: 63.1586 bits (152), Expect = 1.066e-12
Identity = 27/59 (45.76%), Postives = 36/59 (61.02%), Query Frame = 1

Query:   67 CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C++    C LPK +G C G    +++N  S +CE   YGGC GN NRF+TIEEC  +C 
Sbjct: 1497 CQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCP 1555

HSP 2 Score: 48.9062 bits (115), Expect = 8.246e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C   +  G C  Y + +F+N  S +CE   YGGC GN NRF + +EC ++C
Sbjct: 1265 QSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

HSP 3 Score: 47.7506 bits (112), Expect = 2.496e-7
Identity = 21/55 (38.18%), Postives = 28/55 (50.91%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NSVC   K  G C  +   +++NK  G C    YGGC G  NRF   ++C   C+
Sbjct: 1444 NSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ 1498

HSP 4 Score: 46.595 bits (109), Expect = 6.405e-7
Identity = 23/78 (29.49%), Postives = 40/78 (51.28%), Query Frame = 1

Query:   13 NMKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            N+ S      S +      + R++ C L   +G C+G F+++++   +G C    Y GC GN NRF++ ++C   C K
Sbjct: 1351 NIVSPPQQSASPVVVPSNSKQRDA-CHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

[Close]

Query:   67 CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C++    C LPK +G C G    +++N  S +CE   YGGC GN NRF+TIEEC  +C 
Sbjct: 1497 CQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCP 1555

HSP 2 Score: 48.9062 bits (115), Expect = 8.246e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C   +  G C  Y + +F+N  S +CE   YGGC GN NRF + +EC ++C
Sbjct: 1265 QSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

HSP 3 Score: 47.7506 bits (112), Expect = 2.496e-7
Identity = 21/55 (38.18%), Postives = 28/55 (50.91%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NSVC   K  G C  +   +++NK  G C    YGGC G  NRF   ++C   C+
Sbjct: 1444 NSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ 1498

HSP 4 Score: 46.595 bits (109), Expect = 6.405e-7
Identity = 23/78 (29.49%), Postives = 40/78 (51.28%), Query Frame = 1

Query:   13 NMKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            N+ S      S +      + R++ C L   +G C+G F+++++   +G C    Y GC GN NRF++ ++C   C K
Sbjct: 1351 NIVSPPQQSASPVVVPSNSKQRDA-CHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

[Close]

Query:   67 CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C++    C LPK +G C G    +++N  S +CE   YGGC GN NRF+TIEEC  +C 
Sbjct: 1497 CQNHKDACQLPKVQGPCSGKHSYYYYNTASHQCETFTYGGCLGNTNRFATIEECQARCP 1555

HSP 2 Score: 48.9062 bits (115), Expect = 8.246e-8
Identity = 22/57 (38.60%), Postives = 33/57 (57.89%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C   +  G C  Y + +F+N  S +CE   YGGC GN NRF + +EC ++C
Sbjct: 1265 QSMEDICRSRQDAGPCETYSDQWFYNAFSQECETFTYGGCGGNLNRFRSKDECEQRC 1321

HSP 3 Score: 47.7506 bits (112), Expect = 2.496e-7
Identity = 21/55 (38.18%), Postives = 28/55 (50.91%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NSVC   K  G C  +   +++NK  G C    YGGC G  NRF   ++C   C+
Sbjct: 1444 NSVCDEAKDTGPCTNFVTKWYYNKADGTCNRFHYGGCQGTNNRFDNEQQCKAACQ 1498

HSP 4 Score: 46.595 bits (109), Expect = 6.405e-7
Identity = 23/78 (29.49%), Postives = 40/78 (51.28%), Query Frame = 1

Query:   13 NMKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            N+ S      S +      + R++ C L   +G C+G F+++++   +G C    Y GC GN NRF++ ++C   C K
Sbjct: 1351 NIVSPPQQSASPVVVPSNSKQRDA-CHLNVDQGRCKGAFDSWYYEVATGSCVTFKYTGCGGNANRFASKDQCESLCVK 1427

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Match: CG2816 (gene:FBgn0031564 transcript:FBtr0300299)

HSP 1 Score: 56.9954 bits (136), Expect = 6.661e-12
Identity = 26/56 (46.43%), Postives = 33/56 (58.93%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            R  +CL P   G C GY E++ +N     CE  +YGGC GN+NRFST  EC   C+
Sbjct:   27 RVKLCLQPMISGRCFGYVESYAYNPIKRHCEPFIYGGCGGNDNRFSTKAECEFNCR 82

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Match: IM33 (gene:FBgn0031561 transcript:FBtr0077546)

HSP 1 Score: 56.225 bits (134), Expect = 1.493e-11
Identity = 29/82 (35.37%), Postives = 43/82 (52.44%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLP---KQEGM--CRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            MK I  +   F         ++ +C LP      G+  C  +  +F ++ E+  CE+ +YGGC GNENRF T E C +KCK+
Sbjct:    1 MKFIAAVCLMFALVAVALGLKDPICGLPAGIDGNGLIKCAAFIPSFSYHPETNSCEKFIYGGCGGNENRFGTQELCEQKCKE 82

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Match: IM33 (gene:FBgn0031561 transcript:FBtr0345610)

HSP 1 Score: 56.225 bits (134), Expect = 1.493e-11
Identity = 29/82 (35.37%), Postives = 43/82 (52.44%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLP---KQEGM--CRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            MK I  +   F         ++ +C LP      G+  C  +  +F ++ E+  CE+ +YGGC GNENRF T E C +KCK+
Sbjct:    1 MKFIAAVCLMFALVAVALGLKDPICGLPAGIDGNGLIKCAAFIPSFSYHPETNSCEKFIYGGCGGNENRFGTQELCEQKCKE 82

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Match: Ppn (gene:FBgn0003137 transcript:FBtr0300337)

HSP 1 Score: 58.5362 bits (140), Expect = 5.712e-11
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            VCLLPK  G C G+ + ++F+ +  +CEE  YGGC G  NRF ++E+C   C
Sbjct: 1670 VCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTC 1721

HSP 2 Score: 53.5286 bits (127), Expect = 2.556e-9
Identity = 23/58 (39.66%), Postives = 32/58 (55.17%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            E     C LPK+ G C  Y   ++F+   G C    YGGC+GN+NRF +  EC + C+
Sbjct: 1606 EPPQKACGLPKETGTCNNYSVKYYFDTSYGGCARFWYGGCDGNDNRFESEAECKDTCQ 1663

HSP 3 Score: 48.521 bits (114), Expect = 1.685e-7
Identity = 20/54 (37.04%), Postives = 30/54 (55.56%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
             C  P + G C G FE ++++ E+  C    YGGC GN+N + T   CN  C++
Sbjct: 1729 TCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQ 1782

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Match: Ppn (gene:FBgn0003137 transcript:FBtr0301839)

HSP 1 Score: 58.151 bits (139), Expect = 5.859e-11
Identity = 24/52 (46.15%), Postives = 34/52 (65.38%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            VCLLPK  G C G+ + ++F+ +  +CEE  YGGC G  NRF ++E+C   C
Sbjct: 1670 VCLLPKSAGPCTGFTKKWYFDVDRNRCEEFQYGGCYGTNNRFDSLEQCQGTC 1721

HSP 2 Score: 53.9138 bits (128), Expect = 2.356e-9
Identity = 23/58 (39.66%), Postives = 32/58 (55.17%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            E     C LPK+ G C  Y   ++F+   G C    YGGC+GN+NRF +  EC + C+
Sbjct: 1606 EPPQKACGLPKETGTCNNYSVKYYFDTSYGGCARFWYGGCDGNDNRFESEAECKDTCQ 1663

HSP 3 Score: 52.373 bits (124), Expect = 7.862e-9
Identity = 20/54 (37.04%), Postives = 32/54 (59.26%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C +P + G C  Y  +++++ +   C +  YGGC GNENRF T E C  +C +
Sbjct: 1791 ICEIPAEVGECANYVTSWYYDTQDQACRQFYYGGCGGNENRFPTEESCLARCDR 1844

HSP 4 Score: 50.8322 bits (120), Expect = 2.781e-8
Identity = 21/51 (41.18%), Postives = 31/51 (60.78%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            C  P   G C  +   + +N+  G+C+   YGGC GN+NRF+T EEC+ +C
Sbjct: 1944 CSQPADPGQCDKWALHWNYNETEGRCQSFYYGGCGGNDNRFATEEECSARC 1994

HSP 5 Score: 49.2914 bits (116), Expect = 8.100e-8
Identity = 21/61 (34.43%), Postives = 34/61 (55.74%), Query Frame = 1

Query:   73 SRNSVCLLPKQEGMCRG---YFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            S   +CLLP   G C G   +   ++++ E+G C   +Y GC+GN+N F + E C  +C+ 
Sbjct: 2256 SAKEICLLPVATGRCNGPSVHERRWYYDDEAGNCVSFIYAGCSGNQNNFRSFEACTNQCRP 2316

HSP 6 Score: 48.521 bits (114), Expect = 1.494e-7
Identity = 20/54 (37.04%), Postives = 30/54 (55.56%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
             C  P + G C G FE ++++ E+  C    YGGC GN+N + T   CN  C++
Sbjct: 1729 TCEQPVESGPCAGNFERWYYDNETDICRPFTYGGCKGNKNNYPTEHACNYNCRQ 1782

HSP 7 Score: 46.9802 bits (110), Expect = 5.282e-7
Identity = 22/52 (42.31%), Postives = 27/52 (51.92%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            VC  P   G C  +   ++FN  S  CE   YGGC+G  NRFS + EC   C
Sbjct: 2195 VCNEPVTTGPCTDWQTKYYFNTASQACEPFTYGGCDGTGNRFSDLFECQTVC 2246

HSP 8 Score: 46.2098 bits (108), Expect = 9.100e-7
Identity = 23/57 (40.35%), Postives = 30/57 (52.63%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            E   S C L  + G C      +F+N   G C+E VY GC GN N ++T EEC  +C
Sbjct: 2008 EHDTSKCFLAFEPGNCYNNVTRWFYNSAEGLCDEFVYTGCGGNANNYATEEECQNEC 2064

HSP 9 Score: 45.0542 bits (105), Expect = 2.427e-6
Identity = 20/53 (37.74%), Postives = 28/53 (52.83%), Query Frame = 1

Query:   82 SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            SVC  P + G C      +F++ E+  C    Y GC GN NRF T ++C  +C
Sbjct: 2135 SVCAEPPEAGECDNRTTAWFYDSENMACTAFTYTGCGGNGNRFETRDQCERQC 2187

HSP 10 Score: 44.2838 bits (103), Expect = 4.697e-6
Identity = 20/56 (35.71%), Postives = 29/56 (51.79%), Query Frame = 1

Query:   73 SRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            SR  VC      G C  +   + F+++ G C +  YG C GN NRF T  +C ++C
Sbjct: 1860 SRQDVCDEEPAPGECSTWVLKWHFDRKIGACRQFYYGNCGGNGNRFETENDCQQRC 1915

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
Match: CR545476.3 (pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:23915065:23940181:-1 gene:ENSDARG00000114020.1 transcript:ENSDART00000190370.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:CR545476.3)

HSP 1 Score: 62.3882 bits (150), Expect = 2.826e-12
Identity = 24/54 (44.44%), Postives = 33/54 (61.11%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LPK+EG C  +   + ++  SG C    YGGC GN+NRF T +EC + C K
Sbjct: 2755 ICKLPKEEGSCAKFVLKWHYDPLSGNCTRFWYGGCGGNQNRFDTQDECEKACGK 2808

HSP 2 Score: 52.7582 bits (125), Expect = 7.952e-9
Identity = 21/54 (38.89%), Postives = 34/54 (62.96%), Query Frame = 1

Query:   88 CLLPKQEGM-CRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C L    G+ C+ Y   ++F++++G C +  YGGC GN+NRF T  +C ++C K
Sbjct: 2671 CSLDFDTGLPCKDYQAKWYFDRKNGFCTQFWYGGCGGNDNRFETESDCLKRCMK 2724

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
Match: col6a3 (collagen, type VI, alpha 3 [Source:ZFIN;Acc:ZDB-GENE-070501-8])

HSP 1 Score: 62.3882 bits (150), Expect = 2.826e-12
Identity = 24/54 (44.44%), Postives = 33/54 (61.11%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LPK+EG C  +   + ++  SG C    YGGC GN+NRF T +EC + C K
Sbjct: 2787 ICKLPKEEGSCAKFVLKWHYDPLSGNCTRFWYGGCGGNQNRFDTQDECEKACGK 2840

HSP 2 Score: 52.7582 bits (125), Expect = 7.953e-9
Identity = 21/54 (38.89%), Postives = 34/54 (62.96%), Query Frame = 1

Query:   88 CLLPKQEGM-CRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            C L    G+ C+ Y   ++F++++G C +  YGGC GN+NRF T  +C ++C K
Sbjct: 2703 CSLDFDTGLPCKDYQAKWYFDRKNGFCTQFWYGGCGGNDNRFETESDCLKRCMK 2756

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
Match: col6a3 (collagen, type VI, alpha 3 [Source:ZFIN;Acc:ZDB-GENE-070501-8])

HSP 1 Score: 62.3882 bits (150), Expect = 2.839e-12
Identity = 24/54 (44.44%), Postives = 33/54 (61.11%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LPK+EG C  +   + ++  SG C    YGGC GN+NRF T +EC + C K
Sbjct: 3666 ICKLPKEEGSCAKFVLKWHYDPLSGNCTRFWYGGCGGNQNRFDTQDECEKACGK 3719

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:ZFIN;Acc:ZDB-GENE-060503-38])

HSP 1 Score: 60.4622 bits (145), Expect = 5.977e-12
Identity = 29/53 (54.72%), Postives = 33/53 (62.26%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +C   K+EG CRG F  +FFN  S +CE   YGGC GNEN F   EEC E CK
Sbjct:   89 ICRFQKKEGPCRGLFSRYFFNMTSMQCEPFTYGGCQGNENNFRNPEECIEYCK 141

HSP 2 Score: 52.373 bits (124), Expect = 6.398e-9
Identity = 27/76 (35.53%), Postives = 39/76 (51.32%), Query Frame = 1

Query:   34 ILTSFIFFVKYCESR-------NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +L + + F+   ES          VCLL  +EG C    + F++N  S +CEE  Y GC GN+N F +  EC + C
Sbjct:    5 LLGALLLFISVLESAVGLTLQPKEVCLLQIEEGTCNDDIQRFYYNTISQQCEEFSYSGCGGNQNNFRSFVECQKTC 80

[Close]

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +C   K+EG CRG F  +FFN  S +CE   YGGC GNEN F   EEC E CK
Sbjct:   89 ICRFQKKEGPCRGLFSRYFFNMTSMQCEPFTYGGCQGNENNFRNPEECIEYCK 141

HSP 2 Score: 52.373 bits (124), Expect = 6.398e-9
Identity = 27/76 (35.53%), Postives = 39/76 (51.32%), Query Frame = 1

Query:   34 ILTSFIFFVKYCESR-------NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +L + + F+   ES          VCLL  +EG C    + F++N  S +CEE  Y GC GN+N F +  EC + C
Sbjct:    5 LLGALLLFISVLESAVGLTLQPKEVCLLQIEEGTCNDDIQRFYYNTISQQCEEFSYSGCGGNQNNFRSFVECQKTC 80

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Match: itch (itchy E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-976485])

HSP 1 Score: 63.929 bits (154), Expect = 1.063e-12
Identity = 28/65 (43.08%), Postives = 38/65 (58.46%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*ITPT*LNQKI 279
            VC L K+EG CR +   ++++ E+  C    YGGC GNENRFST +EC + C     P  LN  +
Sbjct: 2828 VCNLQKEEGTCRDFVLKWYYDPETKSCARFWYGGCGGNENRFSTQKECEKIC----IPVPLNSSV 2888

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Match: itch (itchy E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-976485])

HSP 1 Score: 63.929 bits (154), Expect = 1.065e-12
Identity = 28/65 (43.08%), Postives = 38/65 (58.46%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*ITPT*LNQKI 279
            VC L K+EG CR +   ++++ E+  C    YGGC GNENRFST +EC + C     P  LN  +
Sbjct: 3008 VCNLQKEEGTCRDFVLKWYYDPETKSCARFWYGGCGGNENRFSTQKECEKIC----IPVPLNSSV 3068

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Match: itch (itchy E3 ubiquitin protein ligase [Source:Xenbase;Acc:XB-GENE-976485])

HSP 1 Score: 63.929 bits (154), Expect = 1.065e-12
Identity = 28/65 (43.08%), Postives = 38/65 (58.46%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*ITPT*LNQKI 279
            VC L K+EG CR +   ++++ E+  C    YGGC GNENRFST +EC + C     P  LN  +
Sbjct: 3025 VCNLQKEEGTCRDFVLKWYYDPETKSCARFWYGGCGGNENRFSTQKECEKIC----IPVPLNSSV 3085

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:548483])

HSP 1 Score: 59.3066 bits (142), Expect = 2.081e-11
Identity = 23/78 (29.49%), Postives = 46/78 (58.97%), Query Frame = 1

Query:   13 NMKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            ++++++        F    +   +VCLLP  EG C+     +++++ +  C+E +YGGC+GN N+F ++E+C + C K
Sbjct:    4 SLQALMAASLLIQVFGSPMQGNTTVCLLPPDEGPCKALIPHYYYDRYTQTCQEFLYGGCDGNSNKFLSMEDCEKFCWK 81

HSP 2 Score: 56.9954 bits (136), Expect = 1.487e-10
Identity = 29/66 (43.94%), Postives = 36/66 (54.55%), Query Frame = 1

Query:   58 VKYCESRN---SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            + +C  R    S C  PK EG C      ++FN ES  CEE VY GC GN N F  +E+C+  CKK
Sbjct:  136 MDFCSPRRDAPSFCYSPKDEGSCSASVTRYYFNIESKACEEFVYTGCGGNSNNFVKMEDCDSVCKK 201

HSP 3 Score: 47.3654 bits (111), Expect = 4.922e-7
Identity = 20/52 (38.46%), Postives = 30/52 (57.69%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
             C +   EG CRG+ + + +N ++ KCE+  YGGC GN+N F     C + C
Sbjct:   88 ACRMDPDEGPCRGFLKRYAYNMQTMKCEQFYYGGCYGNDNNFKDKASCMDFC 139

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Match: ric8a (RIC8 guanine nucleotide exchange factor A [Source:Xenbase;Acc:XB-GENE-5745094])

HSP 1 Score: 52.7582 bits (125), Expect = 5.589e-10
Identity = 22/54 (40.74%), Postives = 34/54 (62.96%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++ C L   +G CR Y   ++++K++  C +  +GGCNGN NRF T EEC + C
Sbjct:   10 DARCTLILDQGPCRTYIIKWYYDKQANSCAQFWFGGCNGNSNRFDTEEECKKIC 63

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Mouse
Match: Spint3 (serine peptidase inhibitor, Kunitz type, 3 [Source:MGI Symbol;Acc:MGI:3651470])

HSP 1 Score: 58.5362 bits (140), Expect = 3.230e-12
Identity = 25/57 (43.86%), Postives = 35/57 (61.40%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +S   +C+LPK  G CR  F  +++N ++GKCE   YGGC GNEN F +  +C   C
Sbjct:   29 KSLPPMCILPKDIGGCRAVFVRWYYNSKTGKCEWFRYGGCKGNENNFPSRSQCQAVC 85

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Mouse
Match: Tfpi (tissue factor pathway inhibitor [Source:MGI Symbol;Acc:MGI:1095418])

HSP 1 Score: 60.8474 bits (146), Expect = 4.274e-12
Identity = 24/54 (44.44%), Postives = 36/54 (66.67%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++ C +   +G C+    ++FFN  + +CEE +YGGC GNENRF T+EEC + C
Sbjct:   47 HTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 59.3066 bits (142), Expect = 1.557e-11
Identity = 24/56 (42.86%), Postives = 36/56 (64.29%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            R   C L +  G+CRGY + + +N ++ +CE  VYGGC GN N F T++EC + C+
Sbjct:  117 RPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++ C +   +G C+    ++FFN  + +CEE +YGGC GNENRF T+EEC + C
Sbjct:   47 HTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 59.3066 bits (142), Expect = 1.557e-11
Identity = 24/56 (42.86%), Postives = 36/56 (64.29%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            R   C L +  G+CRGY + + +N ++ +CE  VYGGC GN N F T++EC + C+
Sbjct:  117 RPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++ C +   +G C+    ++FFN  + +CEE +YGGC GNENRF T+EEC + C
Sbjct:   47 HTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 100

HSP 2 Score: 59.3066 bits (142), Expect = 1.557e-11
Identity = 24/56 (42.86%), Postives = 36/56 (64.29%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            R   C L +  G+CRGY + + +N ++ +CE  VYGGC GN N F T++EC + C+
Sbjct:  117 RPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICE 172

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Mouse
Match: Tfpi (tissue factor pathway inhibitor [Source:MGI Symbol;Acc:MGI:1095418])

HSP 1 Score: 60.8474 bits (146), Expect = 6.185e-12
Identity = 24/54 (44.44%), Postives = 36/54 (66.67%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++ C +   +G C+    ++FFN  + +CEE +YGGC GNENRF T+EEC + C
Sbjct:   40 HTFCAMKADDGPCKAMIRSYFFNMYTHQCEEFIYGGCEGNENRFDTLEECKKTC 93

HSP 2 Score: 59.3066 bits (142), Expect = 1.919e-11
Identity = 26/67 (38.81%), Postives = 43/67 (64.18%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*I-TPT*LNQ 273
            R   C L +  G+CRGY + + +N ++ +CE  VYGGC GN N F T++EC + C+  + +P+ +N+
Sbjct:  110 RPDFCFLEEDPGLCRGYMKRYLYNNQTKQCERFVYGGCLGNRNNFETLDECKKICENPVHSPSPVNE 176

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Match: sp|P0DMW6|VKT3A_ACTEQ (PI-actitoxin-Aeq3a OS=Actinia equina OX=6106 PE=1 SV=1)

HSP 1 Score: 68.9366 bits (167), Expect = 9.096e-16
Identity = 28/55 (50.91%), Postives = 37/55 (67.27%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            NS C LP   G CRGYF  +++N E+GKC++ +YGGC GN N F T+E+C   C 
Sbjct:    3 NSFCQLPAVVGKCRGYFPRYYYNTEAGKCQQFIYGGCGGNRNNFETVEDCRATCH 57

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Match: sp|P0DMW7|VKT3B_ACTEQ (PI-actitoxin-Aeq3b OS=Actinia equina OX=6106 PE=1 SV=1)

HSP 1 Score: 68.1662 bits (165), Expect = 1.586e-15
Identity = 28/55 (50.91%), Postives = 37/55 (67.27%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +S C LP   G CRGYF  F++N E+GKC++ +YGGC GN N F T+E+C   C 
Sbjct:    3 SSFCQLPAVVGKCRGYFPRFYYNTEAGKCQQFIYGGCGGNRNNFETVEDCRATCH 57

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Match: sp|Q8WPI2|BOOH2_RHIMP (Boophilin-H2 OS=Rhipicephalus microplus OX=6941 GN=H2 PE=1 SV=1)

HSP 1 Score: 69.707 bits (169), Expect = 2.690e-15
Identity = 34/75 (45.33%), Postives = 43/75 (57.33%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MK I+++      F +    RN  C LP  EG+C+     F+FN E+GKC    YGGC GNEN F TIEEC + C
Sbjct:    1 MKCIILLAVLGTAFAQ----RNGFCRLPADEGICKALIPRFYFNTETGKCTMFSYGGCGGNENNFETIEECQKAC 71

HSP 2 Score: 51.6026 bits (122), Expect = 3.011e-8
Identity = 24/52 (46.15%), Postives = 31/52 (59.62%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C      G C G  E +F+N +SG+CE  VYGGC GN+N + + EEC   CK
Sbjct:   89 CEPAADSGSCAGQLERWFYNVQSGECETFVYGGCGGNDNNYESEEECELVCK 140

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Match: sp|P0DMX0|VKT3_ANTAF (PI-actitoxin-Axm2b OS=Anthopleura aff. xanthogrammica OX=152178 PE=1 SV=1)

HSP 1 Score: 67.0106 bits (162), Expect = 4.207e-15
Identity = 29/57 (50.88%), Postives = 35/57 (61.40%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
             S N  C LP   G CRGYF  +FF+ E+GKCE  +YGGC GN N F + +EC   C
Sbjct:    1 HSSNDFCYLPAVRGRCRGYFPRYFFSSETGKCERFIYGGCGGNRNNFESAQECGSTC 57

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Match: sp|Q8WPI3|BOOG2_RHIMP (Boophilin-G2 OS=Rhipicephalus microplus OX=6941 GN=G2 PE=1 SV=1)

HSP 1 Score: 68.5514 bits (166), Expect = 1.021e-14
Identity = 32/75 (42.67%), Postives = 43/75 (57.33%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MK ++++      F +    RN  C LP  EG+C+     F+FN E+GKC    YGGC GNEN F TIE+C + C
Sbjct:    1 MKYLILLAVLGTAFAQ----RNGFCRLPADEGICKALIPRFYFNTETGKCTMFSYGGCGGNENNFETIEDCQKAC 71

HSP 2 Score: 49.6766 bits (117), Expect = 1.679e-7
Identity = 24/52 (46.15%), Postives = 30/52 (57.69%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C      G C G  E +F+N  SG+CE  VYGGC GN+N + + EEC   CK
Sbjct:   89 CEPAADSGSCAGQLERWFYNVRSGECETFVYGGCGGNDNNYESEEECELVCK 140

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Match: C8YJ95 (Serine protease inhibitor 3 OS=Tabanus yao OX=485572 PE=2 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 2.657e-17
Identity = 36/76 (47.37%), Postives = 46/76 (60.53%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            MK + +I   F   V +  +++ VC  PK  G C   F  F+FN  SG+CE  +YGGC GNEN FST+EECN KC 
Sbjct:    1 MKVLSLIFVIFSVLVLFASAKDPVCDQPKAVGRCFAAFPKFYFNSSSGQCEAFIYGGCGGNENNFSTLEECNAKCA 76

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Match: G3MS35 (BPTI/Kunitz inhibitor domain-containing protein OS=Amblyomma maculatum OX=34609 PE=2 SV=1)

HSP 1 Score: 78.5666 bits (192), Expect = 7.040e-17
Identity = 31/73 (42.47%), Postives = 44/73 (60.27%), Query Frame = 1

Query:   22 SIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++V++L S        + R   C LP  +G CRGYF +F+F+  SG C + +YGGC GN NRFS++ EC   C
Sbjct:    6 AVVVLLLSIAIAGTSAQGRPRQCFLPPVQGTCRGYFPSFYFDSRSGSCRQFIYGGCGGNANRFSSVRECRRVC 78

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Match: C1IBY4 (Tabserpin OS=Tabanus yao OX=485572 PE=2 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 9.529e-17
Identity = 35/76 (46.05%), Postives = 46/76 (60.53%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            MK + +I   F   V +  +++ VC  PK  G C   F  F+FN  SG+CE  +YGGC GNEN F+T+EECN KC 
Sbjct:    1 MKVLSLIFVLFSVLVLFASAKDPVCDQPKAVGRCFAAFPKFYFNSSSGQCEAFIYGGCGGNENNFNTLEECNAKCA 76

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BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Match: C8YJ94 (Serine protease inhibitor 2 OS=Tabanus yao OX=485572 PE=2 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 5.706e-16
Identity = 33/75 (44.00%), Postives = 46/75 (61.33%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MK + +I   F   V +  +++ VC  PK  G C   F  F++N  SG+C+  +YGGC GNEN F+T+EECN KC
Sbjct:    1 MKVLSLIFVIFSVLVLFASAKDPVCDQPKAVGRCFAAFPKFYYNSSSGQCQAFIYGGCGGNENNFNTLEECNAKC 75

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BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Match: B8QPD3 (Chymotrypsin inhibitor OS=Rhipicephalus microplus OX=6941 PE=2 SV=1)

HSP 1 Score: 74.7146 bits (182), Expect = 2.504e-15
Identity = 30/76 (39.47%), Postives = 47/76 (61.84%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKY-CESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            M ++ ++L   IF        + S+C LP+  G+C  YF +++++  SG C++ +YGGC GNENRFS+ EEC   C
Sbjct:    4 MSALAVLLVLAIFLQNASAHGKPSLCYLPRSRGLCYAYFPSYYYDSSSGTCQDFIYGGCQGNENRFSSREECLRTC 79

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BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Match: ENSAMXT00000039940.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000999.1:23065:40314:1 gene:ENSAMXG00000037874.1 transcript:ENSAMXT00000039940.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 63.5438 bits (153), Expect = 8.515e-13
Identity = 25/54 (46.30%), Postives = 34/54 (62.96%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LPK+EG C  +   +F++  S  C    YGGC GN NRF+T EEC ++C K
Sbjct:  437 ICKLPKEEGTCIKFVLKWFYDSVSNSCTRFWYGGCGGNLNRFNTQEECEKECGK 490

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BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:103023332])

HSP 1 Score: 61.2326 bits (147), Expect = 2.392e-12
Identity = 27/52 (51.92%), Postives = 34/52 (65.38%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            VCLLP  EG CRG    +F+N  + +CEE  YGGC GN N F T +EC++ C
Sbjct:   26 VCLLPAVEGPCRGLVSRYFYNTLTQRCEEFSYGGCGGNANNFVTFQECHKMC 77

HSP 2 Score: 53.5286 bits (127), Expect = 1.827e-9
Identity = 22/53 (41.51%), Postives = 31/53 (58.49%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            +C  P + G CR     +FFN  + +CE+  YGGC GNEN F + + C E C+
Sbjct:   86 ICRFPSEVGPCRALLSRYFFNMTTMQCEQFYYGGCQGNENNFQSHQSCMEYCR 138

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Match: ENSAMXT00000052324.1 (pep primary_assembly:Astyanax_mexicanus-2.0:APWO02000957.1:1173:9398:1 gene:ENSAMXG00000040083.1 transcript:ENSAMXT00000052324.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 57.3806 bits (137), Expect = 4.278e-11
Identity = 24/52 (46.15%), Postives = 32/52 (61.54%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            CL P   GMCRG F   +F+  +  C+   YGGC GN NR+++ EEC  +CK
Sbjct:  123 CLAPAHTGMCRGSFTMLYFDASTQSCKFFTYGGCGGNRNRYTSEEECMSQCK 174

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Match: ENSAMXT00000002208.2 (pep primary_assembly:Astyanax_mexicanus-2.0:13:36140062:36218718:1 gene:ENSAMXG00000002013.2 transcript:ENSAMXT00000002208.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 58.9214 bits (141), Expect = 4.405e-11
Identity = 23/51 (45.10%), Postives = 29/51 (56.86%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            C LP  EG C  Y   ++FN + G C   VY GC GN NR++  EEC + C
Sbjct: 2228 CALPLDEGDCSRYTLHWYFNSQVGACRPFVYSGCGGNANRYTQKEECEKHC 2278

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Match: spint2 (kunitz-type protease inhibitor 2-like [Source:NCBI gene;Acc:103047885])

HSP 1 Score: 58.5362 bits (140), Expect = 5.681e-11
Identity = 24/52 (46.15%), Postives = 32/52 (61.54%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            CL P   GMCRG F   +F+  +  C+   YGGC GN NR+++ EEC  +CK
Sbjct:  300 CLAPAHTGMCRGSFTMLYFDASTQSCKFFTYGGCGGNRNRYTSEEECMSQCK 351

HSP 2 Score: 43.8986 bits (102), Expect = 7.504e-6
Identity = 22/51 (43.14%), Postives = 28/51 (54.90%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            C   K+ G CR     FF+N  SG C+   YGGC GN N + + EEC + C
Sbjct:  223 CQAEKKVGPCRASMPRFFYN--SGTCQRFTYGGCKGNNNNYLSEEECMKTC 271

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BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:ZFIN;Acc:ZDB-GENE-060503-38])

HSP 1 Score: 61.2326 bits (147), Expect = 5.099e-13
Identity = 25/57 (43.86%), Postives = 35/57 (61.40%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            E +   C LP + G CR  F  +FFN+ + +CE  +YGGC+ NEN F T++EC   C
Sbjct:   21 EDQRVTCTLPAKPGDCRAAFPRYFFNRSTLRCESFIYGGCHSNENNFETMQECRAAC 77

HSP 2 Score: 47.3654 bits (111), Expect = 7.676e-8
Identity = 21/52 (40.38%), Postives = 27/52 (51.92%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +C    + G CR +   +F+N   G C   VYGGC GN NRF  +E C   C
Sbjct:   86 LCRPDAETGRCRAHITRYFYNMTLGMCMPFVYGGCGGNNNRFEDMESCVFSC 137

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005038.1 (pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 gene:ENSPMAG00000004579.1 transcript:ENSPMAT00000005038.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 4.351e-10
Identity = 23/53 (43.40%), Postives = 31/53 (58.49%), Query Frame = 1

Query:   82 SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            S C++    G CR Y    F+N+ + +CE   YGGC GN N F ++ ECN KC
Sbjct:    1 SSCMMDLDPGPCRAYLPRVFYNRYTQRCEPFHYGGCFGNGNNFESLAECNAKC 53

HSP 2 Score: 51.2174 bits (121), Expect = 2.804e-9
Identity = 24/64 (37.50%), Postives = 31/64 (48.44%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*ITPT*LNQK 276
             C L  + G+CR     +FFN  SG CEE  YGGC GN N F     C + C     P  + ++
Sbjct:   74 ACRLDMEVGVCRALLRRYFFNMTSGSCEEFGYGGCQGNLNNFKDAASCYQHCVHRAVPLKIKKR 137

HSP 3 Score: 45.4394 bits (106), Expect = 3.345e-7
Identity = 19/52 (36.54%), Postives = 26/52 (50.00%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +CL+    G C      F +N ++  CE   YGGC GN+N FS+   C   C
Sbjct:  166 ICLMKADPGECTAVIPRFHYNPKTSNCESFTYGGCGGNDNNFSSERSCMSVC 217

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000005043.1 (pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 gene:ENSPMAG00000004579.1 transcript:ENSPMAT00000005043.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 53.1434 bits (126), Expect = 4.451e-10
Identity = 23/53 (43.40%), Postives = 31/53 (58.49%), Query Frame = 1

Query:   82 SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            S C++    G CR Y    F+N+ + +CE   YGGC GN N F ++ ECN KC
Sbjct:    1 SSCMMDLDPGPCRAYLPRVFYNRYTQRCEPFHYGGCFGNGNNFESLAECNAKC 53

HSP 2 Score: 50.8322 bits (120), Expect = 3.050e-9
Identity = 24/64 (37.50%), Postives = 31/64 (48.44%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK*ITPT*LNQK 276
             C L  + G+CR     +FFN  SG CEE  YGGC GN N F     C + C     P  + ++
Sbjct:   73 ACRLDMEVGVCRALLRRYFFNMTSGSCEEFGYGGCQGNLNNFKDAASCYQHCVHRAVPLKIKKR 136

HSP 3 Score: 45.4394 bits (106), Expect = 3.330e-7
Identity = 19/52 (36.54%), Postives = 26/52 (50.00%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +CL+    G C      F +N ++  CE   YGGC GN+N FS+   C   C
Sbjct:  165 ICLMKADPGECTAVIPRFHYNPKTSNCESFTYGGCGGNDNNFSSERSCMSVC 216

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Match: WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30912])

HSP 1 Score: 50.447 bits (119), Expect = 6.798e-9
Identity = 22/61 (36.07%), Postives = 38/61 (62.30%), Query Frame = 1

Query:   61 KYCESRN-SVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            ++C+++  ++C LP  +G CR +   + +N    +C+ +VYGGC GNEN F + E C + C
Sbjct:  389 RWCQNQTVNICHLPPVQGPCRDWERHWAYNPLIKQCQLLVYGGCEGNENNFESREACEDNC 449

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Match: WFIKKN1 (WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:30912])

HSP 1 Score: 50.0618 bits (118), Expect = 8.972e-9
Identity = 21/55 (38.18%), Postives = 32/55 (58.18%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            N+ C LP Q+G C+ +   + +N    +C+  +YGGC GNEN F + E C + C 
Sbjct:  371 NNTCSLPVQQGPCKQWALRWAYNPLIKRCQSFIYGGCEGNENNFQSQELCEDNCP 425

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Match: EDO29819 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7T2J6])

HSP 1 Score: 69.3218 bits (168), Expect = 2.684e-17
Identity = 31/56 (55.36%), Postives = 37/56 (66.07%), Query Frame = 1

Query:   73 SRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            S NS C LPK+ G CR      FFN +SGKCE+ +YGGC GN N F T+EEC + C
Sbjct:    9 SGNSACTLPKKVGDCRAAMPRVFFNSQSGKCEDFIYGGCGGNANNFHTMEECKKAC 64

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Match: EDO41696 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3T1])

HSP 1 Score: 62.3882 bits (150), Expect = 1.240e-14
Identity = 28/51 (54.90%), Postives = 35/51 (68.63%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            CL PK  G CR YFE +F+N+ S KC++ VYGGC GN N F +  EC +KC
Sbjct:    2 CLQPKLTGPCRAYFERWFYNQTSRKCKQFVYGGCQGNSNNFESKAECEKKC 52

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Match: EDO26263 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S3T1])

HSP 1 Score: 62.3882 bits (150), Expect = 1.240e-14
Identity = 28/51 (54.90%), Postives = 35/51 (68.63%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            CL PK  G CR YFE +F+N+ S KC++ VYGGC GN N F +  EC +KC
Sbjct:    2 CLQPKLTGPCRAYFERWFYNQTSRKCKQFVYGGCQGNSNNFESKAECEKKC 52

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Match: EDO41922 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S322])

HSP 1 Score: 58.9214 bits (141), Expect = 3.192e-13
Identity = 26/55 (47.27%), Postives = 35/55 (63.64%), Query Frame = 1

Query:   76 RNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            + S C LP   G C  Y  +F+++ +  KC+E +YGGCNGN NRF T E+C E C
Sbjct:    5 QPSFCSLPAVTGRCMAYIPSFYYDMKEEKCKEFIYGGCNGNLNRFDTQEKCEEAC 59

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Match: EDO38467 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SCV4])

HSP 1 Score: 58.151 bits (139), Expect = 6.329e-13
Identity = 25/54 (46.30%), Postives = 32/54 (59.26%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LP + G C G+   +F N  SG CE+  Y GC GN NRF T+ +C  KC K
Sbjct:    1 ICDLPAEAGSCDGHMPLYFHNSTSGLCEKFHYSGCEGNANRFPTMRKCQRKCMK 54

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Match: COL6A3 (collagen type VI alpha 3 chain [Source:NCBI gene;Acc:101161016])

HSP 1 Score: 67.781 bits (164), Expect = 3.143e-14
Identity = 26/54 (48.15%), Postives = 35/54 (64.81%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            +C LPKQEG C  +   ++++  S  C    YGGC+GN+NRF T EEC E C+K
Sbjct: 2638 ICQLPKQEGSCAEFALKWYYDTTSKSCTRFWYGGCDGNQNRFDTQEECKEACEK 2691

HSP 2 Score: 47.3654 bits (111), Expect = 4.766e-7
Identity = 19/52 (36.54%), Postives = 31/52 (59.62%), Query Frame = 1

Query:   88 CLLPKQEGM-CRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            C L    GM C+ Y   +++ +++G C +  YGGC GN+NRF +   C ++C
Sbjct: 2551 CSLGFDPGMPCKDYQAKWYYERQNGFCTQFWYGGCGGNDNRFDSEALCLKRC 2602

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Match: tfpi2 (tissue factor pathway inhibitor 2 [Source:NCBI gene;Acc:101174930])

HSP 1 Score: 58.151 bits (139), Expect = 4.823e-11
Identity = 24/52 (46.15%), Postives = 32/52 (61.54%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +C  PK+EG CR  F ++FFN  + +CE   YGGC GN NRF  +  C + C
Sbjct:  143 ICRFPKEEGHCRALFPSYFFNMSTMQCEPFSYGGCGGNSNRFRDLTSCMDFC 194

HSP 2 Score: 53.9138 bits (128), Expect = 1.697e-9
Identity = 29/73 (39.73%), Postives = 39/73 (53.42%), Query Frame = 1

Query:   34 ILTSFIFFVKYCESRNSV----CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            +LT F  F       + V    CLL   EG CRG  E +F+N  + KCE   YGGC+GN N F + ++C + C
Sbjct:   62 MLTLFALFSSLPGGLSLVPKGACLLRVDEGPCRGQIERYFYNTITQKCEVFYYGGCHGNANNFMSFQKCQKTC 134

HSP 3 Score: 49.2914 bits (116), Expect = 7.710e-8
Identity = 26/70 (37.14%), Postives = 36/70 (51.43%), Query Frame = 1

Query:   37 LTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            LTS + F    +S   +CL P  +G C      F++NK +  CEE  Y GC G+ N F + E C + C K
Sbjct:  187 LTSCMDFCSPQKSVPILCLDPLDKGKCSASMRRFYYNKATKTCEEFAYSGCGGSSNNFVSRESCEDVCLK 256

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Match: ENSORLT00000012975.2 (pep primary_assembly:ASM223467v1:12:15740273:15760140:1 gene:ENSORLG00000010354.2 transcript:ENSORLT00000012975.2 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 7.278e-11
Identity = 25/52 (48.08%), Postives = 34/52 (65.38%), Query Frame = 1

Query:   85 VCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            VC      G+C GYFE +F+N   G+CE  +YGGC GN+N F T +EC ++C
Sbjct:  124 VCAQAPDSGLCFGYFERYFYNFRKGRCEIFIYGGCLGNQNNFLTEKECLQRC 175

HSP 2 Score: 54.6842 bits (130), Expect = 3.642e-10
Identity = 25/61 (40.98%), Postives = 35/61 (57.38%), Query Frame = 1

Query:   55 FVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEK 237
             V    +   VC      G+C GYFE +F+N   G+CE  +YGGC GN+N F T +EC ++
Sbjct:   62 LVSLPSASTGVCAQAPDSGLCFGYFERYFYNFRKGRCEIFIYGGCLGNQNNFLTEKECLQR 122

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Match: ENSORLT00000018112.2 (tissue factor pathway inhibitor [Source:NCBI gene;Acc:101174546])

HSP 1 Score: 56.9954 bits (136), Expect = 1.666e-10
Identity = 24/54 (44.44%), Postives = 33/54 (61.11%), Query Frame = 1

Query:   79 NSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            N +C +    G CR   + +FFN  + +CEE  YGGC+GN N F T++EC E C
Sbjct:   37 NELCAMKADPGPCRAIKDRYFFNVSTARCEEFEYGGCSGNSNNFVTLQECEETC 90

HSP 2 Score: 49.6766 bits (117), Expect = 6.796e-8
Identity = 21/52 (40.38%), Postives = 30/52 (57.69%), Query Frame = 1

Query:   88 CLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCK 243
            C L +  G CRG    +FF+ ++ +C    YGGC GN N F ++ EC  KC+
Sbjct:   99 CHLEEAPGPCRGLLSRYFFDSKTRQCRRFFYGGCFGNANNFWSMAECQAKCQ 150

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Match: ENSORLT00000044137.1 (pep primary_assembly:ASM223467v1:2:16334979:16376346:1 gene:ENSORLG00000025630.1 transcript:ENSORLT00000044137.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 56.6102 bits (135), Expect = 2.466e-10
Identity = 25/57 (43.86%), Postives = 35/57 (61.40%), Query Frame = 1

Query:   70 ESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            + R S+ L+P   G CR Y   ++++K++  C +  YGGCNGN NRF T EEC   C
Sbjct:  955 DPRCSLVLVP---GTCRDYNIRWYYDKQANACAQFWYGGCNGNGNRFDTEEECKRTC 1008

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Match: SMESG000013911.1 (SMESG000013911.1)

HSP 1 Score: 151.754 bits (382), Expect = 2.414e-49
Identity = 76/77 (98.70%), Postives = 76/77 (98.70%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            MKS VIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK
Sbjct:    1 MKSFVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 77

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Match: SMESG000013909.1 (SMESG000013909.1)

HSP 1 Score: 78.5666 bits (192), Expect = 1.509e-20
Identity = 39/77 (50.65%), Postives = 47/77 (61.04%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKCKK 246
            M  I+      IF +++ E R   CLL   +G CR  F  FFFN E+GKCEE VYGGC GN+N F T EEC E C+K
Sbjct:    1 MNFIITFSIFVIFAIQFIECRKPECLLEMDQGPCRAAFPMFFFNTETGKCEEFVYGGCLGNDNLFGTYEECQENCEK 77

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Match: SMESG000037999.1 (SMESG000037999.1)

HSP 1 Score: 74.7146 bits (182), Expect = 6.439e-19
Identity = 36/75 (48.00%), Postives = 45/75 (60.00%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MKS +++L       +  ESR   C  PKQ GMC  YF+ F+FN E+GKCE  +YGGC  N N F T +EC E C
Sbjct:    1 MKSKILVLVVLFSLSQLLESRLKECNEPKQSGMCEAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 75

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Match: SMESG000037999.1 (SMESG000037999.1)

HSP 1 Score: 74.3294 bits (181), Expect = 7.243e-19
Identity = 36/75 (48.00%), Postives = 45/75 (60.00%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MKS +++L       +  ESR   C  PKQ GMC  YF+ F+FN E+GKCE  +YGGC  N N F T +EC E C
Sbjct:    3 MKSKILVLVVLFSLSQLLESRLKECNEPKQSGMCEAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 77

[Close]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Match: SMESG000037995.1 (SMESG000037995.1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.038e-18
Identity = 36/75 (48.00%), Postives = 45/75 (60.00%), Query Frame = 1

Query:   16 MKSIVIILTSFIFFVKYCESRNSVCLLPKQEGMCRGYFETFFFNKESGKCEEMVYGGCNGNENRFSTIEECNEKC 240
            MKS +++L       +  ESR   C  PKQ GMC  YF+ F+FN E+GKCE  +YGGC  N N F T +EC E C
Sbjct:    3 MKSKILVLVVLFSLSQLLESRLKECNEPKQSGMCMAYFKRFYFNSETGKCETFIYGGCGKNGNNFQTEDECEELC 77

The following BLAST results are available for this feature:

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Human
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Celegans
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Mouse
BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Yeast
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
TFPI	1.095e-11	42.86	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
TFPI	1.095e-11	42.86	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
TFPI	1.756e-11	44.44	tissue factor pathway inhibitor [Source:HGNC Symbo...	[more]
COL6A3	1.887e-11	37.50	collagen type VI alpha 3 chain [Source:HGNC Symbol...	[more]
COL6A3	1.887e-11	37.50	collagen type VI alpha 3 chain [Source:HGNC Symbol...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
mig-6	1.926e-13	46.67	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	1.926e-13	46.67	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	1.066e-12	45.76	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	1.066e-12	45.76	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]
mig-6	1.066e-12	45.76	Papilin [Source:UniProtKB/Swiss-Prot;Acc:O76840]	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG2816	6.661e-12	46.43	gene:FBgn0031564 transcript:FBtr0300299	[more]
IM33	1.493e-11	35.37	gene:FBgn0031561 transcript:FBtr0077546	[more]
IM33	1.493e-11	35.37	gene:FBgn0031561 transcript:FBtr0345610	[more]
Ppn	5.712e-11	46.15	gene:FBgn0003137 transcript:FBtr0300337	[more]
Ppn	5.859e-11	46.15	gene:FBgn0003137 transcript:FBtr0301839	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CR545476.3	2.826e-12	44.44	pep chromosome:GRCz11:CHR_ALT_CTG9_1_11:23915065:2...	[more]
col6a3	2.826e-12	44.44	collagen, type VI, alpha 3 [Source:ZFIN;Acc:ZDB-GE...	[more]
col6a3	2.839e-12	44.44	collagen, type VI, alpha 3 [Source:ZFIN;Acc:ZDB-GE...	[more]
tfpi2	5.977e-12	54.72	tissue factor pathway inhibitor 2 [Source:ZFIN;Acc...	[more]
tfpi2	5.977e-12	54.72	tissue factor pathway inhibitor 2 [Source:ZFIN;Acc...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
itch	1.063e-12	43.08	itchy E3 ubiquitin protein ligase [Source:Xenbase;...	[more]
itch	1.065e-12	43.08	itchy E3 ubiquitin protein ligase [Source:Xenbase;...	[more]
itch	1.065e-12	43.08	itchy E3 ubiquitin protein ligase [Source:Xenbase;...	[more]
tfpi2	2.081e-11	29.49	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
ric8a	5.589e-10	40.74	RIC8 guanine nucleotide exchange factor A [Source:...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Spint3	3.230e-12	43.86	serine peptidase inhibitor, Kunitz type, 3 [Source...	[more]
Tfpi	4.274e-12	44.44	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Tfpi	4.274e-12	44.44	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Tfpi	4.274e-12	44.44	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]
Tfpi	6.185e-12	44.44	tissue factor pathway inhibitor [Source:MGI Symbol...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P0DMW6\|VKT3A_ACTEQ	9.096e-16	50.91	PI-actitoxin-Aeq3a OS=Actinia equina OX=6106 PE=1 ...	[more]
sp\|P0DMW7\|VKT3B_ACTEQ	1.586e-15	50.91	PI-actitoxin-Aeq3b OS=Actinia equina OX=6106 PE=1 ...	[more]
sp\|Q8WPI2\|BOOH2_RHIMP	2.690e-15	45.33	Boophilin-H2 OS=Rhipicephalus microplus OX=6941 GN...	[more]
sp\|P0DMX0\|VKT3_ANTAF	4.207e-15	50.88	PI-actitoxin-Axm2b OS=Anthopleura aff. xanthogramm...	[more]
sp\|Q8WPI3\|BOOG2_RHIMP	1.021e-14	42.67	Boophilin-G2 OS=Rhipicephalus microplus OX=6941 GN...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
C8YJ95	2.657e-17	47.37	Serine protease inhibitor 3 OS=Tabanus yao OX=4855...	[more]
G3MS35	7.040e-17	42.47	BPTI/Kunitz inhibitor domain-containing protein OS...	[more]
C1IBY4	9.529e-17	46.05	Tabserpin OS=Tabanus yao OX=485572 PE=2 SV=1	[more]
C8YJ94	5.706e-16	44.00	Serine protease inhibitor 2 OS=Tabanus yao OX=4855...	[more]
B8QPD3	2.504e-15	39.47	Chymotrypsin inhibitor OS=Rhipicephalus microplus ...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSAMXT00000039940.1	8.515e-13	46.30	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
tfpi2	2.392e-12	51.92	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
ENSAMXT00000052324.1	4.278e-11	46.15	pep primary_assembly:Astyanax_mexicanus-2.0:APWO02...	[more]
ENSAMXT00000002208.2	4.405e-11	45.10	pep primary_assembly:Astyanax_mexicanus-2.0:13:361...	[more]
spint2	5.681e-11	46.15	kunitz-type protease inhibitor 2-like [Source:NCBI...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
tfpi2	5.099e-13	43.86	tissue factor pathway inhibitor 2 [Source:ZFIN;Acc...	[more]
ENSPMAT00000005038.1	4.351e-10	43.40	pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 g...	[more]
ENSPMAT00000005043.1	4.451e-10	43.40	pep scaffold:Pmarinus_7.0:GL481015:31246:35903:1 g...	[more]
WFIKKN1	6.798e-9	36.07	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]
WFIKKN1	8.972e-9	38.18	WAP, follistatin/kazal, immunoglobulin, kunitz and...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0


Match Name	E-value	Identity	Description

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO29819	2.684e-17	55.36	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41696	1.240e-14	54.90	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO26263	1.240e-14	54.90	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO41922	3.192e-13	47.27	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO38467	6.329e-13	46.30	Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
COL6A3	3.143e-14	48.15	collagen type VI alpha 3 chain [Source:NCBI gene;A...	[more]
tfpi2	4.823e-11	46.15	tissue factor pathway inhibitor 2 [Source:NCBI gen...	[more]
ENSORLT00000012975.2	7.278e-11	48.08	pep primary_assembly:ASM223467v1:12:15740273:15760...	[more]
ENSORLT00000018112.2	1.666e-10	44.44	tissue factor pathway inhibitor [Source:NCBI gene;...	[more]
ENSORLT00000044137.1	2.466e-10	43.86	pep primary_assembly:ASM223467v1:2:16334979:163763...	[more]

BLAST of Kunitz-type serine protease inhibitor C4 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000013911.1	2.414e-49	98.70	SMESG000013911.1	[more]
SMESG000013909.1	1.509e-20	50.65	SMESG000013909.1	[more]
SMESG000037999.1	6.439e-19	48.00	SMESG000037999.1	[more]
SMESG000037999.1	7.243e-19	48.00	SMESG000037999.1	[more]
SMESG000037995.1	1.038e-18	48.00	SMESG000037995.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence

transcript sequence

>SMED30018720 ID=SMED30018720|Name=Kunitz-type serine protease inhibitor C4|organism=Schmidtea mediterranea sexual|type=transcript|length=329bp
ATAAATTGGTAGAACATGAAATCAATTGTAATAATTTTAACTTCCTTCAT
ATTTTTTGTGAAATATTGTGAAAGTCGAAATTCTGTATGTCTTTTACCAA
AACAAGAAGGAATGTGTAGGGGTTACTTTGAAACGTTCTTCTTCAATAAA
GAAAGTGGTAAATGCGAAGAAATGGTGTATGGAGGATGTAATGGAAATGA
AAATAGATTTTCAACAATTGAAGAATGCAATGAAAAGTGTAAAAAATAAA
TAACGCCAACTTAATTAAATCAGAAAATTTGAGAAAATTCTTTTAAAATT
CTTTTATTTTTATCTAAAATTGAATTCGA

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **cellular component**
Term	Definition
GO:0005576	extracellular region

Vocabulary: **biological process**
Term	Definition
GO:0010466	negative regulation of peptidase activity
GO:0006508	proteolysis
GO:0010951	negative regulation of endopeptidase activity

Vocabulary: **molecular function**
Term	Definition
GO:0030414	peptidase inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0008233	peptidase activity

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000418	head
PLANA:0000420	parapharyngeal region

Vocabulary: **INTERPRO**
Term	Definition
IPR036880	Kunitz_BPTI_sf
IPR002223	Kunitz_BPTI

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PRINTS	PR00759	BASICPTASE	coord: 60..75 score: 47.96 coord: 22..36 score: 34.85 coord: 50..60 score: 54.67
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	SMART	SM00131	KU_2	coord: 23..76 e-value: 2.5E-20 score: 83.5
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PFAM	PF00014	Kunitz_BPTI	coord: 24..76 e-value: 6.5E-18 score: 64.7
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	PROSITE	PS50279	BPTI_KUNITZ_2	coord: 25..75 score: 14.471
IPR002223	Pancreatic trypsin inhibitor Kunitz domain	CDD	cd00109	KU	coord: 23..76 e-value: 3.28809E-18 score: 68.4306
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	GENE3D	G3DSA:4.10.410.10		coord: 19..77 e-value: 4.1E-21 score: 76.7
IPR036880	Pancreatic trypsin inhibitor Kunitz domain superfamily	SUPERFAMILY	SSF57362	BPTI-like	coord: 14..76
None	No IPR available	PANTHER	PTHR10083:SF328	TISSUE FACTOR PATHWAY INHIBITOR	coord: 18..76
None	No IPR available	PANTHER	PTHR10083	KUNITZ-TYPE PROTEASE INHIBITOR-RELATED	coord: 18..76
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..20 score: 0.712

Main menu

Kunitz-type serine protease inhibitor C4

Zeng et. al., 2018

▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Davies et. al., 2017

PAGE et. al., 2020

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 5

Owlery

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