retinoblastoma-like protein

Overview
Nameretinoblastoma-like protein (AFY07415.1)
Smed IDSMED30018689
Length (bp)3435
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of retinoblastoma-like protein (SMED30018689) t-SNE clustered cells

Violin plots show distribution of expression levels for retinoblastoma-like protein (SMED30018689) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of retinoblastoma-like protein (SMED30018689) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for retinoblastoma-like protein (SMED30018689) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30018689

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 4

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30018689SMESG000055551.1 SmedASXL_016270SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30018689SMESG000055551.1 SmedASXL_016270SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015
FACS sorted cell population asexual adult RNA-sequencing evidence
epidermisSMED30018689SMESG000055551.1 dd_Smed_v4_6879_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30018689SMESG000055551.1 dd_Smed_v4_6879_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of retinoblastoma-like protein vs. Ensembl Human
Match: RBL2 (RB transcriptional corepressor like 2 [Source:HGNC Symbol;Acc:HGNC:9894])

HSP 1 Score: 338.191 bits (866), Expect = 9.241e-98
Identity = 207/643 (32.19%), Postives = 340/643 (52.88%), Query Frame = 1
Query:   76 EDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKA--TAKPCAG----KHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            E    Q+ +RF++LC  L ++   + EAWD Y+ +S +Y ++G+ L WL CALY   RKS  T +  +++  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  DFH ++ K     P +++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + I   Y EY+++ G+ DERI+L  +A EEIG+++   N    +   T +A R   + I    +    D  KA   + P  G    K N+     VS     ++             L  +L+  +   SE+L  +L+T C   P + I  RL ++                    I  Q  Q D     C  +   K + +A EM          L YK+     E  + +L ++D+S +L++D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W+ +S LW+ +     + P+ +EV PP+ +E++
Sbjct:   39 ESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLN----AGSGTETAERVQMKNI----LQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLS------------RLHTMLTGLRNAPSEKLEQILRT-CSRDPTQAIANRLKEM------------------FEIYSQHFQPDEDFSNCAKEIASKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERA 631          

HSP 2 Score: 110.923 bits (276), Expect = 7.054e-24
Identity = 83/286 (29.02%), Postives = 142/286 (49.65%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKT--NTGITTGGLPTDCKTNVH------------------------TSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRI--SNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            SL+LFFR +Y L+++RLRD+C +L IS +L  KIWT FE  I +   L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  +   N+G +      +  T ++                        ++P    RL        +E R D+ +FYN++++      +K F + Y                      SQ  ++ P LSP P       +   + RRI  S N  +++SP K +  +SP+ ++ +  ++SPSK LR+
Sbjct:  835 SLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKV-TKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYI----KQIKTFAMKY----------------------SQANMDAPPLSPYPF------VRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLRE 1087          
BLAST of retinoblastoma-like protein vs. Ensembl Human
Match: RBL1 (RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893])

HSP 1 Score: 327.405 bits (838), Expect = 1.002e-94
Identity = 200/641 (31.20%), Postives = 337/641 (52.57%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRY-MQEVIN-----CGAVPGS----VDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSG-KAPSIDEVTPPERIEQSFKQGN 1980
             + LC +L ++     EA D +  +  NY ++G+   WL C+LY   RKS    +    ++   VSL R+L  +K+S +QFF ++ KW DM ++ +E R+RIER+E  F VS VIF KY   F +IFQ   +E        ++ ++ C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I +NA++  ++Q L N SF+GLPSDFH  ++ A E  P ++  +CE +D   ++ K  ++ +F+ YI KL +++++KG     + +L   +F  NS+ +   Y EY++  GDFDERI+L  +A EEIG+      +  L      + + Y +Q+          + P +    +  ++A   P A      A+  VSRL                    ++++  +   S++L ++ ++ C  +P+E+I+  L  +   F   Y  +  D +    I F       ++ R +    +YY  LE ++  E                    +L+ +D+S LL++D FHR+L A C+EIVL    S + FPW++EVL LQ  +FYK++E+ +R  + L R+MVK+ + + E +++S +W  DS LW++L  S  K P+ +EV  P     +F+ GN
Sbjct:   21 LQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKG-----ECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVAS-----ATQSVSRLQ-------------------SIVAGLKNAPSDQLINIFES-CVRNPVENIMKILKGIGETFCQHYT-QSTDEQPGSHIDF-------AVNRLKLAEILYYKILETVMVQETR------------------RLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFP----NNFETGN 601          

HSP 2 Score: 118.242 bits (295), Expect = 3.907e-26
Identity = 87/258 (33.72%), Postives = 132/258 (51.16%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIES-----VKTNTGITTGGLPTDCKTNVHT-SPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKR-VTFTVNSSPSK 2970
            R  SLALF+R +Y L+S+RLRD+C +L +S +L  KIWT FE  +     L+KDR +DQ++LC  + + +V       F EI++ YR QPQ+   +YRSVL++S     V  N  I       DC     T +P  +   +  KE R D+ +FYN +++      VK F + Y ++  +                    ++ P LSP P   +  Q  GS  RRIS   +I++SP K    ++P+  + +  N SPSK
Sbjct:  784 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEER-TFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKTPDCSSGPV--KEERGDLIKFYNTIYV----GRVKSFALKYDLANQDH------------------MMDAPPLSPFP---HIKQQPGS-PRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSK 1012          
BLAST of retinoblastoma-like protein vs. Ensembl Human
Match: RBL1 (RB transcriptional corepressor like 1 [Source:HGNC Symbol;Acc:HGNC:9893])

HSP 1 Score: 327.405 bits (838), Expect = 1.934e-94
Identity = 200/641 (31.20%), Postives = 337/641 (52.57%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRY-MQEVIN-----CGAVPGS----VDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSG-KAPSIDEVTPPERIEQSFKQGN 1980
             + LC +L ++     EA D +  +  NY ++G+   WL C+LY   RKS    +    ++   VSL R+L  +K+S +QFF ++ KW DM ++ +E R+RIER+E  F VS VIF KY   F +IFQ   +E        ++ ++ C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I +NA++  ++Q L N SF+GLPSDFH  ++ A E  P ++  +CE +D   ++ K  ++ +F+ YI KL +++++KG     + +L   +F  NS+ +   Y EY++  GDFDERI+L  +A EEIG+      +  L      + + Y +Q+          + P +    +  ++A   P A      A+  VSRL                    ++++  +   S++L ++ ++ C  +P+E+I+  L  +   F   Y  +  D +    I F       ++ R +    +YY  LE ++  E                    +L+ +D+S LL++D FHR+L A C+EIVL    S + FPW++EVL LQ  +FYK++E+ +R  + L R+MVK+ + + E +++S +W  DS LW++L  S  K P+ +EV  P     +F+ GN
Sbjct:   21 LQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVTHWLACSLYVACRKSIIPTVGKGIMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKYEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRQDLLNPSFKGLPSDFHTADFTASEEPPCIIAVLCELHDGLLVEAKGIKEHYFKPYISKLFDRKILKG-----ECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFTRDTPLGKLTAQANVEYNLQQHFEKKRSFAPSTPLTGRRYLREKEAVITPVAS-----ATQSVSRLQ-------------------SIVAGLKNAPSDQLINIFES-CVRNPVENIMKILKGIGETFCQHYT-QSTDEQPGSHIDF-------AVNRLKLAEILYYKILETVMVQETR------------------RLHGMDMSVLLEQDIFHRSLMACCLEIVLFAYSSPRTFPWIIEVLNLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWSHDSALWEALQVSANKVPTCEEVIFP----NNFETGN 601          

HSP 2 Score: 122.865 bits (307), Expect = 1.314e-27
Identity = 89/262 (33.97%), Postives = 135/262 (51.53%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIES-----VKTNTGITTGGLPTDCKTNVHT-SPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKR-VTFTVNSSPSKELRD 2982
            R  SLALF+R +Y L+S+RLRD+C +L +S +L  KIWT FE  +     L+KDR +DQ++LC  + + +V       F EI++ YR QPQ+   +YRSVL++S     V  N  I       DC     T +P  +   +  KE R D+ +FYN +++      VK F + Y ++  +                    ++ P LSP P   +  Q  GS  RRIS   +I++SP K    ++P+  + +  N SPSK L+D
Sbjct:  784 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEER-TFQEIMKSYRNQPQANSHVYRSVLLKSIPREVVAYNKNINDDFEMIDCDLEDATKTPDCSSGPV--KEERGDLIKFYNTIYV----GRVKSFALKYDLANQDH------------------MMDAPPLSPFP---HIKQQPGS-PRRISQQHSIYISPHKNGSGLTPRSALLYKFNGSPSKSLKD 1016          
BLAST of retinoblastoma-like protein vs. Ensembl Human
Match: RBL2 (RB transcriptional corepressor like 2 [Source:HGNC Symbol;Acc:HGNC:9894])

HSP 1 Score: 301.597 bits (771), Expect = 7.744e-89
Identity = 193/601 (32.11%), Postives = 314/601 (52.25%), Query Frame = 1
Query:  202 GDQLQWLVCALYECVRKS-TTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKA--TAKPCAG----KHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            G+ L WL CALY   RKS  T +  +++  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  DFH ++ K     P +++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + I   Y EY+++ G+ DERI+L  +A EEIG+++   N    +   T +A R   + I    +    D  KA   + P  G    K N+     VS     ++             L  +L+  +   SE+L  +L+T C   P + I  RL ++                    I  Q  Q D     C  +   K + +A EM          L YK+     E  + +L ++D+S +L++D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W+ +S LW+ +     + P+ +EV PP+ +E++
Sbjct:    7 GNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLN----AGSGTETAERVQMKNI----LQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLS------------RLHTMLTGLRNAPSEKLEQILRT-CSRDPTQAIANRLKEM------------------FEIYSQHFQPDEDFSNCAKEIASKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERA 557          
BLAST of retinoblastoma-like protein vs. Ensembl Human
Match: RB1 (RB transcriptional corepressor 1 [Source:HGNC Symbol;Acc:HGNC:9884])

HSP 1 Score: 148.288 bits (373), Expect = 1.422e-35
Identity = 224/1060 (21.13%), Postives = 412/1060 (38.87%), Query Frame = 1
Query:   70 DYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQ-----WLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDW---IASNALISKSKQL----FNSSFRGLPSDFHNRNWKAPERFPT---VLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVL----------ICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCV-DLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRH-----EDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISR-DLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSG-GGGGIQAAKRLRFD 3150
            ++E+ EE     F  LC  L I   V+E AW  +++VS+   + G  +Q     W +C     V      +++ +  T+  L + + +S   F      I       D + ++ + + R+  ++ V   +F K       I+     S     +            + + +W+ ++  K     +  D+++SFQL+LC LD+   ++   L+ +  +      N S R  P    NR+ +  ++      +++ +C+ ++ N  + K+    +F+N+I  +    ++      E   LS              Y E  + + D D R++L+ +   +  S++S        +  TP      +EV     +P     R           NT+                          L+ +L+      SE L      +C  +P E I+ R+  +  +F   +         ++             QR +   ++YY  +E +LKSE  ++ ++                  + S LL  + FH +L A  +E+V+          + S +   FPW+L VL L+A  FYK++E F++   +L REM+K+  +    +++S +W SDS L+D + +S      D   P + +E                                ++ PLN  +QN+  +           +   +  ++ S  + E Q     +T   L    +  SL+LF++ +Y L+ LRL  +C+RL     +L   IWT F+H +  E  L++DR +DQ+++C ++ + +V +  +L F  I+  Y+  P + +E ++ VLI+                                  +E  D I  FYN VF+       +R   N L   S      T P               P LSP+P          S+  RI    NI++SP K+   +S    T T  +  S+ L             V  G SF ++++ +       ++  VL RS  G    +  K+LRFD
Sbjct:   48 EFEETEE---PDFTALCQKLKIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAV------DLDEMSFTFTELQKNIEISVHKFFNLLKEI-------DTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTEINSAL--------VLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVIPINGSPRT-PRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNV---YFKNFIPFMNSLGLVTSNGLPEVENLS------------KRYEEIYLKNKDLDARLFLDHDKTLQTDSIDS------FETQRTPRKSNLDEEV---NVIPPHTPVRTVM--------NTIQQ------------------------LMMILNSASDQPSENLISYF-NNCTVNPKESILKRVKDIGYIFKEKFAKAVGQGCVEI-----------GSQRYKLGVRLYYRVMESMLKSEEERLSIQ------------------NFSKLLNDNIFHMSLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSK-----DREGPTDHLE--------------------------------SACPLNLPLQNNHTAADMYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPL----KSTSLSLFYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNI-DLKFKIIVTAYKDLPHAVQETFKRVLIK----------------------------------EEEYDSIIVFYNSVFM-------QRLKTNILQYAS------TRP---------------PTLSPIPHIPRSPYKFPSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRIL-------------VSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFD 878          
BLAST of retinoblastoma-like protein vs. Ensembl Celegans
Match: lin-35 (Retinoblastoma-like protein homolog lin-35 [Source:UniProtKB/Swiss-Prot;Acc:G5EDT1])

HSP 1 Score: 95.1301 bits (235), Expect = 1.538e-19
Identity = 132/623 (21.19%), Postives = 259/623 (41.57%), Query Frame = 1
Query:  157 AWDKYKEVSTNYCIDGDQLQWLVCALYECVR----KSTTDNINSLDNTY-VSLARLLSVSKMSFVQFFHRISKWADMVDMNEELR--DRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFP----TVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNL----YGEYMMASGDFDERIYL-----------NPN--ALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGS----VDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLF---LSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKI---ELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFM-RCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLAR 1908
            AW+ Y        ++G +  W + A+Y  +     K     I  L   + VS+  + +   +S  +   + +++ +++   +  R  + I RI+   +VS VIF K+   F +IF++I    G ++         +  ELF   W  ++ +K+       D+I ++QLL   LD + +     K          G+    H+ N K  E       T+++ +C     + +D +   D  F     K +EK  I           S+ NF+     IMN+    Y  Y++  G  DERI++           +P+  ++ +I  V+        +  LT  +  +  E +  G    S      +++    PC   +  + +      +   +  N  +++I S        K +    EE+   +      SPM  I+ + D+++  F   LSA  G+ I+                  +     H      LE++    + KI   EL+ K+R              D+  +++++EF  +++  CVE++L+ +   + FPW  E+  +    F+K++++ +     L R+MV++FS++ E +++ +SW+SDS LW  + R
Sbjct:  150 AWETYNHAVQRVSLEGSESAWQLSAIYYYLLSKGIKRRGKTIRILIQPFPVSILTIANSFDISVAEMLDKTARFVEIIHSRKIRRYQEYIRRIQEGLAVSCVIFKKFCRIFCKIFEEI--KVGSENCP-------SSHELFTVLWTSFLVMKSRM--TVDDLISNYQLLFSILDQVYTEMCSMK---------EGI---VHHLNQKFVEDLLENDCTIIRALCTQFGGSVLDARHFSDHTF-----KKMEKTGIP----------STWNFQEFRDLIMNVPKTAYENYLLQRGSIDERIFIPSVEDFSKIFQSPDTYSVADILKVSYSGRRFRDAEFLTKISNNHCLEKLALGGKVASEKLVTQSKEQPRVPCVEYNLELGNYPDDLESNNQSLYNRLTKIIGS-------WKLENSKLEEVCGTMS----DSPMATILLKSDEMTNKFERTLSAELGETIN------------------ENIPKYHYNVRKELELVFLIFMEKIIVAELKKKVREE------------DLLNVIRREEFLDSVFCFCVELILVSNGYDRPFPWSAELCGVHPFMFHKVIDLMITHEKQLSRQMVQHFSRIEETVIEYFSWKSDSPLWPMVVR 693          

HSP 2 Score: 64.3142 bits (155), Expect = 5.497e-10
Identity = 31/99 (31.31%), Postives = 62/99 (62.63%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI 2523
            +L +F +  YF ++ RL+D+ DR+ +      + W+ F++++  +T +  DR +DQ++LCC+F + ++  S ++ F EI+  YR Q  ++  +YRSV +
Sbjct:  744 TLRIFLKRTYFTAARRLQDLTDRVSMGARAKSQCWSLFDYLLRNDTLIFMDRHLDQILLCCVFVIMKINES-SMLFTEIMAQYRRQSANSLLVYRSVTV 841          
BLAST of retinoblastoma-like protein vs. Ensembl Fly
Match: Rbf (gene:FBgn0015799 transcript:FBtr0070146)

HSP 1 Score: 131.724 bits (330), Expect = 8.158e-31
Identity = 88/352 (25.00%), Postives = 168/352 (47.73%), Query Frame = 1
Query:   76 EDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS----LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ---------KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTP 1092
            +D+ E +   + +LC DL ++   + + ++ Y EVS    ++G    W+ CA+Y   R+++T  +      +    VSL  LL   KMS  +F  +I +W DM ++ +E  + IE ++ +FS++ ++  ++      IF          K    HG  +  +     C+  +L    W L++  K   P+   D++ S+ L++C +D I +N L  K   L N  F GLPS++   +++       +L   C+  +    + K+ + + FR  +    +   I G +     +L++ NFE N + +   Y +Y+++ G+FDERI    +A E     ++  N+  L   +TP
Sbjct:   22 DDRLEMINAEYTNLCRDLNMDRQTELQGYETYLEVSQRCSMEGTASHWMCCAIYTACRRTSTPTVTGQNAVVKGNCVSLNNLLRCCKMSIYEFKTKIKQWCDMANLPQEFVNEIEDLDRKFSITFMLHKRFRIIMDMIFSCPPNEKKHSKYISLHGNHAHGK-----CSYIKLDDICWRLFLCAKNQKPSNTVDLVTSYNLMICCIDLIYNNVLAEKRTDLINPKFEGLPSNWTELDFRHNPH--CILSNFCDMTE----EAKAMKATTFRQIMSSFFQASTIYGNKDTMLGLLANENFERNLKSLNISYEQYVLSVGEFDERILSAYDAGE-----HTALNDQSLRPPVTP 357          

HSP 2 Score: 94.3597 bits (233), Expect = 3.248e-19
Identity = 75/251 (29.88%), Postives = 122/251 (48.61%), Query Frame = 1
Query: 2230 LALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSP-AKTQITMSPKRVTFTVNSSPSKELR 2979
            L +F R +Y L  LR++ +C  L +       IW  FEH IT ET L+KDR +DQ I+C I+   RV    +  F +I++ YR QPQ+   +YR V I+       I   G P                     +V+ DI  FYNH ++P     +++F+I+YL    NV+  ++G  S+L             LSP P          +  ++++ + ++FVS  +K +I  SP ++ ++   SP+K+L+
Sbjct:  582 LQIFLRKVYLLGWLRIQKLCSELSLCEKTPESIWHIFEHSITHETELMKDRHLDQNIMCAIYIYIRVKRMEDPKFSDIMRAYRNQPQAVNSVYREVFID-------INEDGEP---------------------KVK-DIIHFYNHTYVP----LMRQFVIDYL----NVTPDVSGRASDL------------QLSPHPKER------AAQPKKVTQSHSLFVSQMSKNEIQQSPNQMVYSFCRSPAKDLQ 777          

HSP 3 Score: 65.855 bits (159), Expect = 2.246e-10
Identity = 45/153 (29.41%), Postives = 75/153 (49.02%), Query Frame = 1
Query: 1495 RCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDE----FHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMR------CVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAP 1923
            R Q     ++Y L+ IL++EI           RN         +ID+  LL +      F+  L A CVE+VL    +   FPWVL+   + A  F KI+EI +R      C++  R ++K+ + + E  ++  +W  +ST+W+ +A S + P
Sbjct:  435 RFQLAKSFFFYLLDQILQAEI-----------RNKP-------DIDLKRLLVQKVSLVIFNITLMACCVELVLEAYKTELKFPWVLDCFSISAFEFQKIIEIVVRHGSHEGCLN--RSLIKHLNSIEETCLERLAWARNSTVWEMIA-SAQLP 566          
BLAST of retinoblastoma-like protein vs. Ensembl Fly
Match: Rbf2 (gene:FBgn0038390 transcript:FBtr0083213)

HSP 1 Score: 86.6557 bits (213), Expect = 7.689e-17
Identity = 77/367 (20.98%), Postives = 150/367 (40.87%), Query Frame = 1
Query:   70 DYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCI---DGDQLQWLVCALYECVRKSTT----DNINSLDNTY-------VSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAIC-GDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVL----------KFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPS 1095
            + E + E L +RF   C  L +E+ +++ A   Y  +     +   + D  +WL CA+Y  +++S      ++IN  +++        VSL RLL   KM+  QF  R+  W  +       +  +E +  +  +++ +   Y   F  +F      H G+  +         + L+ F WLL++ I+   P     ++I   Q+L+CT+D +  NAL      +    F G+P     +NW   +  P +L          + I E      +  K   ++FF   +  L     + G +T    ++     + N   +   Y   +    + DER+ L+     E    + ++ ++   +  +PS
Sbjct:    5 EVEGEAETLVRRFSVSCEQLELEARIQQSALSTYHRLDAVNGLSTSEADAQEWLCCAVYSELQRSKMRDIRESINEANDSVAKNCCWNVSLTRLLRSFKMNVSQFLRRMEHWNWLTQNENTFQLEVEELRCRLGITSTLLRHYKHIFRSLF-----VHPGKGADP--GAANHYQALYEFGWLLFLVIRNELPGFAITNLINGCQVLVCTMDLLFVNALEVPRSVVIRREFSGVP-----KNWDTEDFNPILLNKYSVLEALGELIPELPAKGVVQMK---NAFFHKALIMLYMDHSLVGDDTHMREIIKEGMLDINLENLNRKYTNQVADISEMDERVLLSVQGAIETKGDSPKSPQLAFQTSSSPS 356          
BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Match: rbl2 (retinoblastoma-like 2 (p130) [Source:ZFIN;Acc:ZDB-GENE-061109-2])

HSP 1 Score: 343.199 bits (879), Expect = 3.959e-100
Identity = 209/651 (32.10%), Postives = 348/651 (53.46%), Query Frame = 1
Query:   79 DQEEQLGK---RFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ----KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKS-KQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFI---CESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNS--------RANEMMLSSDLTPSAMRYMQEVINCGAVPGS-VDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGK--APSIDEVTPPERIE 1959
            ++E+ LGK    FE+LC DL ++      AW  Y+ +S NY ++G +L WL C+LY   R S  T +  + +  YVSL R+L  S+ S ++FF ++ KW DM ++  + +   E++E  F+V++VIF KY+  F +IF+    ++  +H G+   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL+  S K L N +F+GLP DF+++++K     P  L FI   CE +D   ++ K  ++ F++ +I+KL E++++KG+E      L  VNF  +   +  +Y E++++SG  DERI+L   A E+IG+           RAN  + +S +T SA+R    +     VP S V T  ++A    G+ +T+ +G   R                               S +L D+ ++ C   P E +  RL ++S +FL  Y G   D K+  R        D +++       +YY +LE+I+  E                  + +L ++D+S +L++D FHR+L A C+EIV+        FP VL++ +L A HFYK++E+ +R  + L RE+VK+ + V E +++S +W+ +S LW+ + R  K   P+  EV PP+ +E
Sbjct:    3 EEEDTLGKTKHAFEELCRDLNMDEESSNRAWRSYENISKNYTLEGSELHWLACSLYVACRSSVPTMSKGTAEGNYVSLTRILRSSQQSLIEFFSKMKKWQDMANLPRDFQQSTEKLERNFTVTSVIFKKYLPLFRDIFKTPTDELPRTHRGR---KQRRHPCTVTEVFNFCWILFIHAKGNFPMISDDLVNSYHLLLCALDLVYCNALLCSSRKDLLNPAFKGLPEDFNSKDYKP---GPGSLCFIEQLCELHDGLVLEAKGAKEHFWKPFIKKLFERKILKGKEDTLTGFLEPVNFGDSLASLNRVYEEHVLSSGSLDERIFLGDGAREDIGTPGPYEGIENQDRANNPLQNS-MTASALRVSTPLTGRRYVPESIVGTPVSSAMQSVGRLHTLLTGFKYR------------------------------PSVKLRDIFRS-CVRDPTESVAARLKEMSEIFLQNYEGTGDDNKSLAR--------DIAVKYFCLAEALYYKSLEVIINQE------------------KKRLGDVDLSGVLEQDVFHRSLIACCLEIVIFSYRPPGEFPRVLQIFDLPAYHFYKVIEVLVRAEEGLFREVVKHLNHVEEQVLESLAWKGNSPLWERI-REAKNCVPTCQEVMPPQHLE 588          

HSP 2 Score: 126.331 bits (316), Expect = 7.448e-29
Identity = 93/288 (32.29%), Postives = 143/288 (49.65%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI-----------ESVKTNTGITTGG----------------------LPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            SL LFFR +Y L+S+RLRD+C +L IS DL  KIWT FE+ +   T L+ DR +DQ+++C I+ +T+V +  + +F  I++ YR QPQ++  +YRSVLI           E+    +  T G                        P+   +    +PGG Q     +E R D+ RFYNHV++  +  +  R+  N   +G                     Q   P L P P +R      +GS  R  +S+N +I++SP KT   +SP+ ++ + V+SSPS  LR+
Sbjct:  770 SLCLFFRKVYHLASVRLRDLCAKLDISADLRRKIWTCFEYSLVHCTDLMMDRHLDQLLMCAIYVMTKV-TKEDKSFQNIMKCYRSQPQASSSVYRSVLISGRKRRHSGNTENTHRQSSPTEGAQEQASGESSPVSMRSSSTLPIPQPSSAPSTPTRAPGGPQ---EQEEERGDLIRFYNHVYIKQIKPFALRYSSNSPKNG---------------------QAETPPLCPYPSLR------IGSPRRVLLSHNHSIYISPHKTGSPISPRDKIFYYVSSSPSHRLRE 1026          
BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Match: rbl1 (retinoblastoma-like 1 (p107) [Source:ZFIN;Acc:ZDB-GENE-030131-8179])

HSP 1 Score: 298.901 bits (764), Expect = 1.190e-84
Identity = 186/632 (29.43%), Postives = 314/632 (49.68%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRK-ATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLAR-SGKAPSIDEVTPPERIEQSFKQGN 1980
            FE LC +L ++     EA   ++ +   Y ++GD + WL C+LY   RKS+   +    ++   VSL R+L  +K+S +QFF ++ KW+DM ++ ++ R RI R+E  F VS VIF K+   F ++FQ             K + L C   ++F+F W L++  K NF  I  D++ S+ LLLC LD +  NAL+ S  K L N +FRGLP D  N      +  P V+  +CE +D   ++ K  ++ +F+ YI+ L EK ++KG       +L + NF+ N++ I   Y E+++  GDFDER++L  +A EEIG+      E        PS     +  +          TR  A + P  G+       V+             S   + + L +++S  +   S+ L  +    C  +P E I+ R+  L   F  AY     D              D + +R +    +Y+  LE ++  E+ +++ +                  D + LL+++  H +L A C+E+VL    S + FPW+LE+ ++   +FYK++E+F+R  + L R+MVK+ + + E +++S +W  DS LW++L + + K P+++EV  P     +F  GN
Sbjct:   22 FEALCQELNMDEETAAEALQNFRSIWNTYTLEGDVMHWLACSLYAACRKSSIPTVGRGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWSDMANLCQDFRSRIGRLERNFEVSTVIFRKFEPIFLDMFQNPQSEPPRMPRSRKHRRLPCHISDVFKFCWTLFVYTKGNFHMIGDDLVNSYHLLLCCLDLVFCNALMCSNRKDLINQNFRGLPKDTENL-----KEMPCVIDKLCELHDGLVVEAKGIKEHYFKPYIKTLFEKRMLKGDVETLTELLDTPNFQDNNKAINRDYEEFVLTVGDFDERVFLGADADEEIGTPRKSTAE-------PPSGHLSARMQVENNLQQHFEKTRSLAPSTPLTGRRYLKEKEVL--------VTPVSSATQSVSRLQSMVSGLRNAPSDALLQIF-ISCSRNPTESILNRVKTLGEKFKQAYTNPTDD--------LPGAHMDFAEKRLKLAEILYFKILENVMTQEMKRLQGK------------------DWAVLLEQEVLHCSLLACCLEVVLFSYSSQRTFPWILEIFQIPPFYFYKVIEVFIRSEEGLSRDMVKHLNSIEEQVLESRAWTRDSALWNALNKDNNKVPTVEEVNFP----SNFDTGN 602          

HSP 2 Score: 127.102 bits (318), Expect = 4.755e-29
Identity = 94/305 (30.82%), Postives = 153/305 (50.16%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI----------ESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRV-TFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            R  SLALFFR +Y L+S+RLRD+C +L IS +L  KIWT FEH +   T L+KDR +DQ++LC ++ ++R+    +  F +I++ YR QPQ+   +YRSVLI          E+++ +         TD   N  +      + +   E R D+ +FYN++++  + ++  ++ ++ L +                      ++  P LSP P +R++       + RR+S   +IFVSP K   +++P    T+    SPSKEL DIN +I       K   +    +   P+    Q N  VL
Sbjct:  768 RTGSLALFFRKVYHLASVRLRDLCLKLDISSELRGKIWTCFEHSLLHCTDLMKDRHLDQLLLCAVYIISRITKEEH-TFQDIMKCYRTQPQANSHVYRSVLIKRRPKVQQADENMEVDPPADQSNERTDQAANERSDQADRTQTVFESEERGDLIQFYNNIYVSKMRSFAFKYALSTLDN----------------------RMEAPPLSPFPSVRSH-----TLSPRRVSQKHSIFVSPHKNSSSLTPSTAYTYRFTGSPSKELSDINQMIRQGGVSKKRAFTMEGDETESPSKCLRQENDDVL 1044          
BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Match: rbl2 (retinoblastoma-like 2 (p130) [Source:ZFIN;Acc:ZDB-GENE-061109-2])

HSP 1 Score: 219.935 bits (559), Expect = 6.828e-62
Identity = 151/553 (27.31%), Postives = 255/553 (46.11%), Query Frame = 1
Query:  157 AWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ----KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNS--------RANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYK 1776
            AW  Y+ +S NY ++G +L WL C+LY   R S  T +  + +  YVSL R+L  S+ S ++FF ++ KW DM ++  + +   E++E  F+V++VIF KY+  F +IF+    ++  +H G+      +  CT  E+F F W+L+I  K                                          GLP DF+++++K        ++ +CE +D   ++ K  ++ F++ +I+KL E++++KG+E      L  VNF  +   +  +Y E++++SG  DERI+L   A E+IG+           RA+ + +S+ LT    RY+ E I        V T  ++A    G+ +T+ +G   R                               S +L D+ ++ C   P E +  RL ++S +FL  Y G   D K      F           C     +YY +LE+I+  E                  + +L ++D+S +L++D FHR+L A C+EIV+        FP VL++ +L A HFYK
Sbjct:    9 AWRSYENISKNYTLEGSELHWLACSLYVACRSSVPTMSKGTAEGNYVSLTRILRSSQQSLIEFFSKMKKWQDMANLPRDFQQSTEKLERNFTVTSVIFKKYLPLFRDIFKTPTDELPRTHRGRKQR---RHPCTVTEVFNFCWILFIHAK------------------------------------------GLPEDFNSKDYKPGPGSLCFIEQLCELHDGLVLEAKGAKEHFWKPFIKKLFERKILKGKEDTLTGFLEPVNFGDSLASLNRVYEEHVLSSGSLDERIFLGDGAREDIGTPGPYEGIENQDRASALRVSTPLT--GRRYVPESI--------VGTPVSSAMQSVGRLHTLLTGFKYR------------------------------PSVKLRDIFRS-CVRDPTESVAARLKEMSEIFLQNYEGTGDDNKNIAVKYF-----------C-LAEALYYKSLEVIINQE------------------KKRLGDVDLSGVLEQDVFHRSLIACCLEIVIFSYRPPGEFPRVLQIFDLPAYHFYK 445          
BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Match: rb1 (retinoblastoma 1 [Source:ZFIN;Acc:ZDB-GENE-040428-1])

HSP 1 Score: 133.265 bits (334), Expect = 4.452e-31
Identity = 173/790 (21.90%), Postives = 315/790 (39.87%), Query Frame = 1
Query:  277 LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVD-MNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIA----SNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPT-----VLKFICESNDMNYIDCKSTRDSFFRNYIEK--LLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLN------PNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLI-----------------CSDSSKH---FPWVLEVLELQAVHFYKIVEIFMRC-VDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENV-EIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCK-IWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI 2523
            L+   ++  + L    +S  QF   + K    VD ++ ++   + R+E+++ V+  ++ +++    +IF + D +                +EL+  +W +++  K  F  +  D+++SFQLLLC L++ A     + L S  K + +SS    P+    RN    +  P      +L+ +C+  D +  + K+   S F  +++   LL  + +   E                  +   Y E    S DFD R++L+      PN +E +  V           ++TP    + +++                A P        A   + +L G +      S   +SN L+                    +C   P  +I  R+++L  +F+  +      +   L             +R     ++YY  +E +LKSE                  E +L+  + S LL    FH +L A  +E+V+                   SDS +    FPW+L V +L A  FYK++E F++    L  +MVK+  Q    +++S +WR+DS L+D L +S +    ++  PP  + Q                                  PL+ N                 AA   LS     +Q  V E E       + R +SL+LF++ +Y ++ LRL+ +   L  S   M   IWT  +H +  E  L++DR +DQ+I+  ++A+ +V +  +L F  I+  Y+  P + +E ++ VLI
Sbjct:   97 LEGINLTFTQFLKAVGLSVKQFISLVRKMDVNVDTISPKVNSAVTRLENKYDVTLALYQRFVKTCEKIFAEPDNAK--------------RKELWESSWTMFLLAKGTFLQMEDDLVISFQLLLCVLEFFAKRLSPSLLQSPYKSVVSSSTLSPPTRTSRRNQGKSKPRPAEMDMQLLETLCKEGDCSVDEVKNVYQSTFCAFLDSVGLLGLQGLPPME-----------------ALSKQYEELYHKSKDFDARLFLSDDETLSPNKIE-VSKV-----------EVTPRKNLFAEDI----------------AIPVPQTPIRAAMTSIQQLRGDLTSG---SDQPSSNLLVYY-----------------KNCTVDPSGEIKKRVEELGEVFIQRFAQAVGQHCEGL-----------GRKRFYLGAQLYYKVMESMLKSE------------------EKRLSVQNFSKLLNNAAFHTSLLACALEVVIATYVGSSLKNGGFGRSSGASDSVESDLCFPWILSVFQLPAFDFYKVIESFIKAEPTLKHDMVKHLEQCEHVIMESLAWRADSPLFDLLKQSREEGPGEQAEPPATLNQ----------------------------------PLHHN---------------HTAADLYLSPVRPCRQPPVMEAEPPTPGTRAPRSNSLSLFYKKLYRMAYLRLKMLFSNLLTSHPEMEPIIWTLLQHTLQNEYELMRDRHLDQLIMSAMYAICKVKNV-DLRFKTIVTAYKELPNTNQETFKRVLI 728          
BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Match: rbl1 (retinoblastoma-like 1 (p107) [Source:ZFIN;Acc:ZDB-GENE-030131-8179])

HSP 1 Score: 86.2705 bits (212), Expect = 2.824e-18
Identity = 67/248 (27.02%), Postives = 117/248 (47.18%), Query Frame = 1
Query: 2368 LLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIE---SVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRV-TFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            L+KDR +DQ++LC ++ ++R+    +  F +I++ YR QPQ+   +YRSVLI+    V+          P D           TQ +  ++E R D+ +FYN++++  + ++  ++ ++ L +                      ++  P LSP P +R++       + RR+S   +IFVSP K   +++P    T+    SPSKEL DIN +I       K   +    +   P+    Q N  VL
Sbjct:    6 LMKDRHLDQLLLCAVYIISRITKEEH-TFQDIMKCYRTQPQANSHVYRSVLIKRRPKVQQADENMEVDPPADQSNERSDQADRTQTVFESEE-RGDLIQFYNNIYVSKMRSFAFKYALSTLDN----------------------RMEAPPLSPFPSVRSH-----TLSPRRVSQKHSIFVSPHKNSSSLTPSTAYTYRFTGSPSKELSDINQMIRQGGVSKKRAFTMEGDETESPSKCLRQENDDVL 224          
BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Match: rbl1 (retinoblastoma-like 1 [Source:NCBI gene;Acc:100216140])

HSP 1 Score: 355.91 bits (912), Expect = 1.810e-105
Identity = 297/1066 (27.86%), Postives = 497/1066 (46.62%), Query Frame = 1
Query:  154 EAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRG-LPS-DFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRA---------NEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPS---LQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVT---PPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRL-GTSAPLNQ--------NIQNSQGSFRHEDDESARAAAQLLS------ANDDEKQENVEIETS--------------HKLVYSI--------------------RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNV---------HTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQL-NQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDR 3102
            + WD+  +     C+ G+   WL CALY   RK     +    ++   VSL R+L  +K+S +QFF+++ KW DM ++ +E R+R+ER+E  F V+ VIF K+   F EIFQ   E         K + L C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I ++ L   +K+ L N SF   LP+ D       + E  P +++ +CE  D  +++ K  ++ +F+ YI KL +K+++KG       +L   +F  N++ +   Y EY++  GDFDER++L  +A EEIGS              NE  L   ++   + Y++E         +V T  ++A  C  +  ++ +G+                             R A  SE+L ++ ++ C  +P+E+++  +  +   F   Y               Q  +  P    + R +    +Y+  LE I+  E SK                 +L+  D++ALL++D FH++L A C+EIVL    S + FPW +EVL L A +FYK++E+F+R  D L R+MVK+ + + E +++S +W SDS LW  L      P+ +EV    P       F    + L   S  +R  + ++    RRL G   P  Q        +I   + +     D++A++  Q ++      AN+  K   + ++TS                L+  +                    +  SLALFFR +Y L+S+RLRD+C +L +S DL  KIWT F + +   T L+KDR +DQ++LC ++ + +++    L FH+I++ YR QPQ+     R ++ +  K       GG P     N+         H +P G          R D+  FYN+V++  V ++  +F                        +S+Q  L + P LSP P I+         + RR+S   +I+VSP K   +++P   + +  N SPSK L+DIN+++       K  ++ +S   S       +++ ++L R
Sbjct:    3 QHWDRSPQPP---CLCGEVKHWLACALYAACRKGVMPTVGKGIMEGNGVSLTRILRSAKLSLIQFFNKMKKWIDMSNLPQEFRERVERLERNFEVATVIFKKFEPIFREIFQNPHEEPPRLPRSRKQRRLRCSAKDLFSFCWTLFVYSKGNFCLIGDDLVNSYHLLLCCLDLIYAHVLQCPNKEDLLNPSFTAKLPALD------PSSEDAPCIIRALCELYDGIFVEAKGIKEHYFKPYISKLYDKKILKGA-----CLLDVSSFTDNNKSLNKEYEEYVLTKGDFDERVFLGVDAEEEIGSPRKFVRVTLAKWFHNEKSLLLKISTVLLSYLKE-------EPTVITPVSSATQCVSRLQSMVAGL-----------------------------RNA-PSEQLIEVFKS-CVRNPLENVLNIVRDIGRRFCHHYT--------------QSTEDQPGSHIVNRWKLAEILYFKVLETIVVQE-SK-----------------RLHGKDLTALLEQDIFHQSLIACCLEIVLFAYSSPRTFPWTIEVLNLSAFYFYKVIEVFIRSEDGLSRDMVKHLNTIEEQILESRAWTSDSVLWVHLDAVDNVPTCEEVRSIWPHLVFCFFFLLDCQPLSPISVHDRYSSPAAGSAKRRLFGDDCPREQTVDKITTPDITRIRIALSPSPDKTAQSIGQTIAIPVQGLANESVKSLFLPMKTSPPQSENYVPVPLTAQALISPLTKRQLGRMPESCPTSARKPKKTGSLALFFRKVYHLASVRLRDLCLKLDVSNDLRRKIWTLFVYSLVHCTDLMKDRHLDQLLLCAVYIMAKISKEERL-FHDIMKCYRNQPQANSHNDR-IICQLAKNG-----GGQPDHIGFNLPFFVDSSDSHPTPSGFTGSPCGNAERGDLITFYNNVYVERVRSFALKF------------------------ASTQDHLMDVPPLSPFPSIKQQ-----AISPRRVSQQHSIYVSPHKNSGSLTPHTALLYKFNGSPSKSLQDINSMLKQEQRSRKRIIAIDSDTESPAKRLCQENDDALLKR 948          
BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Match: RBL2 (retinoblastoma-like 2 [Source:NCBI gene;Acc:100490373])

HSP 1 Score: 313.538 bits (802), Expect = 2.527e-89
Identity = 187/641 (29.17%), Postives = 335/641 (52.26%), Query Frame = 1
Query:   85 EEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRY-MQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFL----SAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARS-GKAPSIDEVTPPERIEQSFKQG 1977
            EEQL  R+++LC  L ++   + EAW+ Y  +S NY ++G+ L WL C+LY   R++  T    +++  YVSL ++LS S++S ++FF++I KW DM ++  E R R +++E  F+VSAV+F KY   F E+F+  ++E        ++ +  CT  E+++F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL     ++L N +F+GLP DF +R +KAP   P +++ +C  +D   ++ K  ++ F++ YI KL +K+++KG+       L   NF  + + I   Y  Y++++G+ DER+++  +  EEIG +    N  +    +  + + Y +Q+  +         + + +    + K+    S   + ++         S +   + L  +L+  +   SE L  ML++ C   P + I+ RL ++S  F     S    +F   K   R+                   +YY  LE ++  E                  + +L +ID+S++L++D FHR+L + C+EI +       +FP ++ + EL    FYK++E+ ++  + L RE+VK+ + + E +++  +W  DS LWD +  + GK P  +EV  P+  E+S   G
Sbjct:   30 EEQLRCRYDELCSSLNMDERARGEAWEYYSRISQNYTLEGNALHWLACSLYVACRQTVPTVGRGTVEGNYVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRTKKLERNFTVSAVLFKKYDPIFQEVFRSPLEEQPRQHRGRKQRRQPCTVSEVYQFCWVLFIHTKGNFPMISDDLVNSYHLLLCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAPLEAPCIIETLCGLHDGLVLEAKGIKEHFWKPYIRKLFDKKILKGKSDSLVGFLDPGNFADSVKAINKAYEGYVLSAGNLDERVFME-DVEEEIGRIGQCLNPSLGMESVERAKVTYNLQQNFD------KFKSLRVSTPLTSLKYIRECSPCTTPIS---------SAMYCVSRLFTILTGFKPAPSERLLQMLRS-CSRDPTKTILRRLKEMSETFCENTDSVAEKQFYITKKYFRL----------------AEVLYYKVLESVIDQE------------------KKRLGDIDMSSILEQDVFHRSLMSCCLEITVFSYKPPGNFPSIIVMFELAPYQFYKVIEVVIKAEEGLCREVVKHLNNIEEQILECMAWTHDSPLWDKIRENDGKIPLCEEVLHPQHFEKSGDNG 619          

HSP 2 Score: 94.7449 bits (234), Expect = 5.877e-19
Identity = 56/193 (29.02%), Postives = 105/193 (54.40%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVK-----TNTGITTGGLPTDCKTNV--------------------HTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRF 2706
            +  SL LF R +Y L+S+RL+D+C +L IS +L  KIWT FE  +     L+KDR +DQ+++C ++ +T+V +  + +FH I++ YR+QP ++  +YRSVL++  +     ++  I   G P +   ++                    +++P    R+        +E R D+ +FYN++++  + ++  RF
Sbjct:  794 KASSLTLFCRRVYCLASIRLKDLCLKLDISDELRRKIWTCFEFSLVHCPELIKDRHLDQLLMCAVYVITKV-TKEDTSFHNIMKCYRVQPHASSHVYRSVLLKKRRRRQSGSSDHILQPGSPAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAGSNFVEEERGDLVQFYNNIYIEKIKSFAMRF 985          
BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Match: RBL2 (retinoblastoma-like 2 [Source:NCBI gene;Acc:100490373])

HSP 1 Score: 310.457 bits (794), Expect = 2.451e-88
Identity = 186/635 (29.29%), Postives = 335/635 (52.76%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRY-MQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARS-GKAPSIDEVTPPERIEQSFKQG 1977
            QL  R+++LC  L ++   + EAW+ Y  +S NY ++G+ L WL C+LY   R++  T    +++  YVSL ++LS S++S ++FF++I KW DM ++  E R R +++E  F+VSAV+F KY   F E+F+  ++E        ++ +  CT  E+++F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL     ++L N +F+GLP DF +R +KAP   P +++ +C  +D   ++ K  ++ F++ YI KL +K+++KG+       L   NF  + + I   Y  Y++++G+ DER+++  +  EEIG +    N  +    +  + + Y +Q+  +         + + +    + K+    S   + ++         S +   + L  +L+  +   SE L  ML++ C   P + I+ RL ++S  F    N   +  K                Q C+   K Y+   E+          L YK+     +  + +L +ID+S++L++D FHR+L + C+EI +       +FP ++ + EL    FYK++E+ ++  + L RE+VK+ + + E +++  +W  DS LWD +  + GK P  +EV  P+  E+S   G
Sbjct:   17 QLRCRYDELCSSLNMDERARGEAWEYYSRISQNYTLEGNALHWLACSLYVACRQTVPTVGRGTVEGNYVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRTKKLERNFTVSAVLFKKYDPIFQEVFRSPLEEQPRQHRGRKQRRQPCTVSEVYQFCWVLFIHTKGNFPMISDDLVNSYHLLLCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAPLEAPCIIETLCGLHDGLVLEAKGIKEHFWKPYIRKLFDKKILKGKSDSLVGFLDPGNFADSVKAINKAYEGYVLSAGNLDERVFME-DVEEEIGRIGQCLNPSLGMESVERAKVTYNLQQNFD------KFKSLRVSTPLTSLKYIRECSPCTTPIS---------SAMYCVSRLFTILTGFKPAPSERLLQMLRS-CSRDPTKTILRRLKEMSETFCE--NTDSVAEK----------------QFCRDITKKYFRLAEV----------LYYKVLESVIDQEKKRLGDIDMSSILEQDVFHRSLMSCCLEITVFSYKPPGNFPSIIVMFELAPYQFYKVIEVVIKAEEGLCREVVKHLNNIEEQILECMAWTHDSPLWDKIRENDGKIPLCEEVLHPQHFEKSGDNG 606          

HSP 2 Score: 94.3597 bits (233), Expect = 6.802e-19
Identity = 56/193 (29.02%), Postives = 105/193 (54.40%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVK-----TNTGITTGGLPTDCKTNV--------------------HTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRF 2706
            +  SL LF R +Y L+S+RL+D+C +L IS +L  KIWT FE  +     L+KDR +DQ+++C ++ +T+V +  + +FH I++ YR+QP ++  +YRSVL++  +     ++  I   G P +   ++                    +++P    R+        +E R D+ +FYN++++  + ++  RF
Sbjct:  781 KASSLTLFCRRVYCLASIRLKDLCLKLDISDELRRKIWTCFEFSLVHCPELIKDRHLDQLLMCAVYVITKV-TKEDTSFHNIMKCYRVQPHASSHVYRSVLLKKRRRRQSGSSDHILQPGSPAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAGSNFVEEERGDLVQFYNNIYIEKIKSFAMRF 972          
BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Match: RBL2 (retinoblastoma-like 2 [Source:NCBI gene;Acc:100490373])

HSP 1 Score: 298.901 bits (764), Expect = 2.526e-84
Identity = 183/637 (28.73%), Postives = 328/637 (51.49%), Query Frame = 1
Query:   85 EEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRY-MQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARS-GKAPSIDEVTPPERIEQSFKQG 1977
            EEQL  R+++LC  L ++   + EAW+ Y  +S NY ++G+ L WL C+LY   R++  T    +++  YVSL ++LS S++S ++FF++I KW DM ++  E R R +++E  F+VSAV+F KY   F E+F+  ++E        ++ +  CT  E+++F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL     ++L N +F+GLP DF +R +KAP   P +++ +C  +D   ++ K  ++ F++ YI KL +K+V    + K   V    +     + I   Y  Y++++G+ DER+++  +  EEIG +    N  +    +  + + Y +Q+  +         + + +    + K+    S   + ++         S +   + L  +L+  +   SE L  ML++ C   P + I+ RL ++S  F    +     Y     +L                   YY  LE ++  E                  + +L +ID+S++L++D FHR+L + C+EI +       +FP ++ + EL    FYK++E+ ++  + L RE+VK+ + + E +++  +W  DS LWD +  + GK P  +EV  P+  E+S   G
Sbjct:   36 EEQLRCRYDELCSSLNMDERARGEAWEYYSRISQNYTLEGNALHWLACSLYVACRQTVPTVGRGTVEGNYVSLTQILSSSELSLIEFFNKIKKWEDMANLPTEFRTRTKKLERNFTVSAVLFKKYDPIFQEVFRSPLEEQPRQHRGRKQRRQPCTVSEVYQFCWVLFIHTKGNFPMISDDLVNSYHLLLCALDLVYGNALQCPNRRELLNPNFQGLPEDFCSREYKAPLEAPCIIETLCGLHDGLVLEAKGIKEHFWKPYIRKLFDKKV----QNKGQLVTGYSSCNIYMKAINKAYEGYVLSAGNLDERVFME-DVEEEIGRIGQCLNPSLGMESVERAKVTYNLQQNFD------KFKSLRVSTPLTSLKYIRECSPCTTPIS---------SAMYCVSRLFTILTGFKPAPSERLLQMLRS-CSRDPTKTILRRLKEMSETFCENTDNITKKYFRLAEVL-------------------YYKVLESVIDQE------------------KKRLGDIDMSSILEQDVFHRSLMSCCLEITVFSYKPPGNFPSIIVMFELAPYQFYKVIEVVIKAEEGLCREVVKHLNNIEEQILECMAWTHDSPLWDKIRENDGKIPLCEEVLHPQHFEKSGDNG 614          

HSP 2 Score: 94.7449 bits (234), Expect = 6.328e-19
Identity = 56/193 (29.02%), Postives = 105/193 (54.40%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVK-----TNTGITTGGLPTDCKTNV--------------------HTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRF 2706
            +  SL LF R +Y L+S+RL+D+C +L IS +L  KIWT FE  +     L+KDR +DQ+++C ++ +T+V +  + +FH I++ YR+QP ++  +YRSVL++  +     ++  I   G P +   ++                    +++P    R+        +E R D+ +FYN++++  + ++  RF
Sbjct:  789 KASSLTLFCRRVYCLASIRLKDLCLKLDISDELRRKIWTCFEFSLVHCPELIKDRHLDQLLMCAVYVITKV-TKEDTSFHNIMKCYRVQPHASSHVYRSVLLKKRRRRQSGSSDHILQPGSPAENTKDICSREPSPVMRSSSTLPVPQPNSAPPTPTRITAAGSNFVEEERGDLVQFYNNIYIEKIKSFAMRF 980          
BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Match: rbl1 (retinoblastoma-like 1 [Source:NCBI gene;Acc:100216140])

HSP 1 Score: 289.656 bits (740), Expect = 2.588e-81
Identity = 194/642 (30.22%), Postives = 321/642 (50.00%), Query Frame = 1
Query:   88 EQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTP-----SAMRYMQEVINCGAVPGSVDTRKATAK--PCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQG 1977
            E + ++ E LC +L ++     E    +    + Y ++G+   WL CALY   RK     +    ++   VSL R+L  +K+S +QFF+++ KW DM ++ +E R+R+ER+E  F V+ VIF K+   F EIFQ   E         K + L C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I ++ L   +K+ L N SF G+P+    +     E  P +++ +CE  D  +++ K  ++ +F+ YI KL +K+++KG       +L   +F  N++ +   Y EY++  GDFDER++L  +A EEIGS      E  +    TP     S ++   E     A P +  T +   K  P      + A+  VSRL                    ++++  +   SE+L ++ ++ C  +P+E+++  +  +   F   Y     D              D ++ R +    +Y+  LE I+  E SK                 +L+  D++ALL++D FH++L A C+EIVL    S + FPW +EVL L A +FYK++E+F+R  D L R+MVK+ + + E +++S +W SDS LW  L      P+ +EV  P   E   + G
Sbjct:   20 EAVQEQLETLCRELNLDQETGAETIRDFTRTWSTYSLEGEVKHWLACALYAACRKGVMPTVGKGIMEGNGVSLTRILRSAKLSLIQFFNKMKKWIDMSNLPQEFRERVERLERNFEVATVIFKKFEPIFREIFQNPHEEPPRLPRSRKQRRLRCSAKDLFSFCWTLFVYSKGNFCLIGDDLVNSYHLLLCCLDLIYAHVLQCPNKEDLLNPSFTGIPA-IDTKYIILSEDAPCIIRALCELYDGIFVEAKGIKEHYFKPYISKLYDKKILKGA-----CLLDVSSFTDNNKSLNKEYEEYVLTKGDFDERVFLGVDAEEEIGSPRKFVVEFPMGI-CTPRKQMESNLQQHFERKRSFA-PSTPLTGRGYLKEEPTVITPVSSATQCVSRLQ-------------------SMVAGLRNAPSEQLIEVFKS-CVRNPLENVLNIVRDIGRRFCHHYTQSTEDQPGS--------HIDFAVNRWKLAEILYFKVLETIVVQE-SK-----------------RLHGKDLTALLEQDIFHQSLIACCLEIVLFAYSSPRTFPWTIEVLNLSAFYFYKVIEVFIRSEDGLSRDMVKHLNTIEEQILESRAWTSDSVLWVHLDAVDNVPTCEEVIIPSNFETGNEAG 607          

HSP 2 Score: 127.487 bits (319), Expect = 4.269e-29
Identity = 92/300 (30.67%), Postives = 155/300 (51.67%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGG-----LPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQL-NQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDR 3102
            SLALFFR +Y L+S+RLRD+C +L +S DL  KIWT F + +   T L+KDR +DQ++LC ++ + +++    L FH+I++ YR QPQ+   +YRSVL++ +   +G  T       +     ++ H +P G          R D+  FYN+V++  V ++  +F                        +S+Q  L + P LSP P I+         + RR+S   +I+VSP K   +++P   + +  N SPSK L+DIN+++       K  ++ +S   S       +++ ++L R
Sbjct:  770 SLALFFRKVYHLASVRLRDLCLKLDVSNDLRRKIWTLFVYSLVHCTDLMKDRHLDQLLLCAVYIMAKISKEERL-FHDIMKCYRNQPQANSHVYRSVLLKRIPQASGDETSTSQDVEMTARNSSDSHPTPSGFTGSPCGNAERGDLITFYNNVYVERVRSFALKF------------------------ASTQDHLMDVPPLSPFPSIKQQ-----AISPRRVSQQHSIYVSPHKNSGSLTPHTALLYKFNGSPSKSLQDINSMLKQEQRSRKRIIAIDSDTESPAKRLCQENDDALLKR 1039          
BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Match: Rbl2 (RB transcriptional corepressor like 2 [Source:MGI Symbol;Acc:MGI:105085])

HSP 1 Score: 340.117 bits (871), Expect = 1.115e-98
Identity = 202/642 (31.46%), Postives = 340/642 (52.96%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMR-YMQEVIN-----------CGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            Q+ +RFE+LC  L ++   + EAW  Y+ +S +Y ++G+ L WL CALY   RKS  T +  + +  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  D H ++ KA    P V++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + +   Y EY++A+G+ DER++L  +A EE+G++    +  + ++  T SA R  M++++            C  + G    ++ +  PC    +T A   +SRL+                    +LS  +   SE+L  +L++ C   P + I  RL ++                    I  Q  Q D +   C     +YY  LE +++ E                  + +L ++D+S +L+ D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W++ S LWD +     + P+ +EV PP+ +E++
Sbjct:   41 QIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDCHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPGNFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTL----SRCLSAASGTESAERTQMRDILQQHLDKSKALRVCTPLTGVRYVQENS--PCVTPVSTAAHS-LSRLH-------------------TMLSGLRNAPSEKLERILRS-CSRDPTQAIADRLKEM------------------YEIYSQHFQPDENFSNC-AKEMLYYKVLESVIEQE------------------QKRLGDMDLSGVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERT 618          

HSP 2 Score: 112.079 bits (279), Expect = 2.346e-24
Identity = 87/303 (28.71%), Postives = 148/303 (48.84%), Query Frame = 1
Query: 2167 KQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTG----GLPTDCKTN--------------------VHTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            +Q+N     +   +   +  SLALFFR +Y+L+ +RLRD+C +L IS +L  KIWT FE  I + T L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  + N+G +        PT+  T+                      ++P    RL        +E R D+ +FYN+++       ++ F + Y                    S +  Q + P LSP P         GS  R ++S +  I++SP   +   SP+ ++ +  ++SPSK LR+
Sbjct:  801 QQQNPGQPLTSSSIRPRKTSSLALFFRKVYYLAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKV-TKEDRSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIY----RKQIQAFAMKY--------------------SQANAQTDTPPLSPYPFVRT-----GSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLRE 1073          
BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Match: Rbl2 (RB transcriptional corepressor like 2 [Source:MGI Symbol;Acc:MGI:105085])

HSP 1 Score: 338.191 bits (866), Expect = 6.610e-98
Identity = 205/644 (31.83%), Postives = 344/644 (53.42%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMR-YMQEVIN-----------CGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            Q+ +RFE+LC  L ++   + EAW  Y+ +S +Y ++G+ L WL CALY   RKS  T +  + +  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  D H ++ KA    P V++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + +   Y EY++A+G+ DER++L  +A EE+G+++      + ++  T SA R  M++++            C  + G    ++ +  PC    +T A  + SRL+                    +LS  +   SE+L  +L++ C   P + I  RL ++                    I  Q  Q D +   C  +  +K + +A EM          L YK+     E  + +L ++D+S +L+ D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W++ S LWD +     + P+ +EV PP+ +E++
Sbjct:   41 QIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDCHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPGNFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTLS----RCLSAASGTESAERTQMRDILQQHLDKSKALRVCTPLTGVRYVQENS--PCVTPVSTAAHSL-SRLH-------------------TMLSGLRNAPSEKLERILRS-CSRDPTQAIADRLKEM------------------YEIYSQHFQPDENFSNCAKEIANKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERT 628          

HSP 2 Score: 112.079 bits (279), Expect = 2.224e-24
Identity = 87/303 (28.71%), Postives = 148/303 (48.84%), Query Frame = 1
Query: 2167 KQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTG----GLPTDCKTN--------------------VHTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            +Q+N     +   +   +  SLALFFR +Y+L+ +RLRD+C +L IS +L  KIWT FE  I + T L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  + N+G +        PT+  T+                      ++P    RL        +E R D+ +FYN+++       ++ F + Y                    S +  Q + P LSP P         GS  R ++S +  I++SP   +   SP+ ++ +  ++SPSK LR+
Sbjct:  811 QQQNPGQPLTSSSIRPRKTSSLALFFRKVYYLAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKV-TKEDRSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIY----RKQIQAFAMKY--------------------SQANAQTDTPPLSPYPFVRT-----GSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLRE 1083          
BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Match: Rbl1 (RB transcriptional corepressor like 1 [Source:MGI Symbol;Acc:MGI:103300])

HSP 1 Score: 331.643 bits (849), Expect = 3.802e-96
Identity = 197/625 (31.52%), Postives = 335/625 (53.60%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRK-ATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL-ARSGKAPSIDEVTPPERIE 1959
             + LC +L ++     EA D +  +  NY ++G+ + WL C+LY   RKS    +    ++   VSL R+L  +K+S +QFF ++ KW DM ++ +E R+RIER+E  F VS VIF K+   F +IFQ   +E        ++ ++ C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I +NA++  +++ L N SF+GLPSDFH  ++KA E  P ++  +C+ +D   ++ K  ++ +F+ YI KL +K+++KG     + +L   +F  NS+ +   Y EY++  GDFDERI+L  +A EEIG+          ++D TP      Q  + C         R  A + P  G+        V+            S   + + L ++++  ++  SE+L ++ ++ C  +PM +II  +  +   F   Y  +  D +    I F       ++ R +    +YY  LE I+  E  +                  L+ +D+S LL++D FH++L A C+EIVL    S + FPW++EVL+LQ  +FYK++E+ +R  + L R+MVK+ + + E +++S +W ++S LW++L A + + PS +EV  P   E
Sbjct:   21 LQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKG-----ECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRK------FTAD-TPFGKLTSQASVECNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVT--------TPVASATQSVSRLQSIVAGLKSAPSEQLLNIFES-CMRNPMGNIIKIVKGIGETFCQHYT-QSTDKQPGSHIDF-------AVNRLKLAEILYYKILETIMVQETRR------------------LHGMDMSVLLEQDIFHKSLMACCLEIVLFAYSSPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFE 598          

HSP 2 Score: 128.257 bits (321), Expect = 2.368e-29
Identity = 99/300 (33.00%), Postives = 149/300 (49.67%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKT------NVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKR-VTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            R  SLALF+R +Y L+S+RLRD+C +L +S +L  KIWT FE  +     L+KDR +DQ++LC  + + +V       F EI++ YR QPQ+   +YRSVL++S+     +  G    DC+       +   +P  +   +  KE R D+ +FYN V++      VK F + Y +S  +                    ++ P LSP P   +  Q  GS  RRIS   +++VSP K    ++P+  + +  N SPSK L+DIN +I     K K  +   S     P     Q N  VL
Sbjct:  783 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEER-TFQEIMKSYRNQPQANSHVYRSVLLKSIPGGVVVYNG----DCEMTDGDIEDATKTPNCSSEPV--KEERGDLIKFYNTVYV----GRVKSFALKYDLSNQDHI------------------MDAPPLSPFP---HIKQQPGS-PRRISQQHSLYVSPHKNGAGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKTKKRVIAISGDADSPAKRLCQENDDVL 1049          
BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Match: Rbl2 (RB transcriptional corepressor like 2 [Source:MGI Symbol;Acc:MGI:105085])

HSP 1 Score: 280.411 bits (716), Expect = 4.693e-78
Identity = 185/643 (28.77%), Postives = 317/643 (49.30%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMR-YMQEVIN-----------CGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            Q+ +RFE+LC  L ++   + EAW  Y+ +S +Y ++G+ L WL CALY   RKS  T +  + +  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K                                          GL  D H ++ KA    P V++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + +   Y EY++A+G+ DER++L  +A EE+G+++      + ++  T SA R  M++++            C  + G    ++ +  PC    +T A  + SRL+                    +LS  +   SE+L  +L++ C   P + I  RL ++                    I  Q  Q D +   C  +  +K + +A EM          L YK+     E  + +L ++D+S +L+ D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W++ S LWD +     + P+ +EV PP+ +E++
Sbjct:   41 QIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAK------------------------------------------GLSEDCHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPGNFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTLS----RCLSAASGTESAERTQMRDILQQHLDKSKALRVCTPLTGVRYVQENS--PCVTPVSTAAHSL-SRLH-------------------TMLSGLRNAPSEKLERILRS-CSRDPTQAIADRLKEM------------------YEIYSQHFQPDENFSNCAKEIANKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERT 585          

HSP 2 Score: 112.079 bits (279), Expect = 2.069e-24
Identity = 85/283 (30.04%), Postives = 141/283 (49.82%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTG----GLPTDCKTN--------------------VHTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            SLALFFR +Y+L+ +RLRD+C +L IS +L  KIWT FE  I + T L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  + N+G +        PT+  T+                      ++P    RL        +E R D+ +FYN+++       ++ F + Y                    S +  Q + P LSP P         GS  R ++S +  I++SP   +   SP+ ++ +  ++SPSK LR+
Sbjct:  788 SLALFFRKVYYLAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKV-TKEDRSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIY----RKQIQAFAMKY--------------------SQANAQTDTPPLSPYPFVRT-----GSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLRE 1040          
BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Match: Rb1 (RB transcriptional corepressor 1 [Source:MGI Symbol;Acc:MGI:97874])

HSP 1 Score: 138.272 bits (347), Expect = 1.309e-32
Identity = 216/1028 (21.01%), Postives = 398/1028 (38.72%), Query Frame = 1
Query:  115 LCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQ-----WLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWI---ASNALISKSKQLFNSSFRG---LPSDFHNRNWKAPERFPT---VLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINS-NYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVL----------ICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRC-VDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISR-DLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGG 3117
            LC  L +   V+E AW  +++VS+   I    +Q     W +C     V      +++ +  T+  L + +  S   F      I       D + ++ + + R+  +++V   ++ K       I+  + +     S E           + + +W+ ++  K     +  D+++SFQL+LC +D+    +  AL+ +  +       G    P    NR+ +  ++      +++ +C+ ++ N  + K+    +F+N+I  +    ++      E   LS              Y E  + + D D R++L+ +   +   ++S        ++ TP                 + D       P    H  V +                  V+N+   L+ +L+      SE L      +C  +P E+I+ R+  +  +F   +         D+            +QR +   ++YY  +E +LKSE  ++ ++                  + S LL  + FH +L A  +E+V+          + S +   FPW+L VL L+A  FYK++E F++   +L REM+K+  +    +++S +W SDS L+D + +S      D + P   +     QGN             T + M         +PL    + +             +  ++ SA + E Q      T   L    +  SLALF++ +Y L+ LRL  +C RL     +L   IWT F+H +  E  L++DR +DQ+++C ++ + +V +  +L F  I+  Y+  P + +E ++ VLI                                   +E  D I  FYN VF+       +R   N L   S      T P               P LSP+P          S+  RI    NI++SP K+   +S    T T  +  S+ L             V  G SF ++++ +       ++  VL RS  GG
Sbjct:   54 LCQKLKVPDHVRERAWLTWEKVSSVDGILEGYIQKKKELWGICIFIAAV------DLDEMPFTFTELQKSIETSVYKFFDLLKEI-------DTSTKVDNAMSRLLKKYNVLCALYSKLERTCELIY--LTQPSSALSTE------INSMLVLKISWITFLLAKGEVLQMEDDLVISFQLMLCVVDYFIKFSPPALLREPYKTAAIPINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNV---YFKNFIPFINSLGIVSSNGLPEVESLS------------KRYEEVYLKNKDLDARLFLDHDKTLQTDPIDS------FETERTPRK--------------NNPDEEANVVTP----HTPVRT------------------VMNTIQQLMVILNSASDQPSENLISYF-NNCTVNPKENILKRVKDVGHIFKEKFANAVGQGCVDI-----------GVQRYKLGVRLYYRVMESMLKSEEERLSIQ------------------NFSKLLNDNIFHMSLLACALEVVMATYSRSTLQHLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKVEANLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDGEGPDNLEPACPLSLPL-QGNH------------TAADMYL-------SPLRSPKKRT-------------STTRVNSAANTETQAASAFHTQKPL----KSTSLALFYKKVYRLAYLRLNTLCARLLSDHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNI-DLKFKIIVTAYKDLPHAAQETFKRVLIR----------------------------------EEEFDSIIVFYNSVFM-------QRLKTNILQYAS------TRP---------------PTLSPIPHIPRSPYKFSSSPLRIPGG-NIYISPLKSPYKISEGLPTPTKMTPRSRIL-------------VSIGESFGTSEKFQKINQMVCNSDRVLKRSAEGG 859          
BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Match: sp|Q08999|RBL2_HUMAN (Retinoblastoma-like protein 2 OS=Homo sapiens OX=9606 GN=RBL2 PE=1 SV=3)

HSP 1 Score: 338.191 bits (866), Expect = 4.438e-97
Identity = 207/643 (32.19%), Postives = 340/643 (52.88%), Query Frame = 1
Query:   76 EDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKA--TAKPCAG----KHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            E    Q+ +RF++LC  L ++   + EAWD Y+ +S +Y ++G+ L WL CALY   RKS  T +  +++  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  DFH ++ K     P +++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + I   Y EY+++ G+ DERI+L  +A EEIG+++   N    +   T +A R   + I    +    D  KA   + P  G    K N+     VS     ++             L  +L+  +   SE+L  +L+T C   P + I  RL ++                    I  Q  Q D     C  +   K + +A EM          L YK+     E  + +L ++D+S +L++D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W+ +S LW+ +     + P+ +EV PP+ +E++
Sbjct:   39 ESPTPQIQQRFDELCSRLNMDEAARAEAWDSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTVEGNYVSLTRILKCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTVSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDFHAKDSKPSSDPPCIIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLYEKKLLKGKEENLTGFLEPGNFGESFKAINKAYEEYVLSVGNLDERIFLGEDAEEEIGTLSRCLN----AGSGTETAERVQMKNI----LQQHFDKSKALRISTPLTGVRYIKENSPCVTPVSTATHSLS------------RLHTMLTGLRNAPSEKLEQILRT-CSRDPTQAIANRLKEM------------------FEIYSQHFQPDEDFSNCAKEIASKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGILEQDAFHRSLLACCLEVVTFSYKPPGNFPFITEIFDVPLYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKPESPLWEKIRDNENRVPTCEEVMPPQNLERA 631          

HSP 2 Score: 110.923 bits (276), Expect = 3.388e-23
Identity = 83/286 (29.02%), Postives = 142/286 (49.65%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKT--NTGITTGGLPTDCKTNVH------------------------TSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRI--SNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            SL+LFFR +Y L+++RLRD+C +L IS +L  KIWT FE  I +   L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  +   N+G +      +  T ++                        ++P    RL        +E R D+ +FYN++++      +K F + Y                      SQ  ++ P LSP P       +   + RRI  S N  +++SP K +  +SP+ ++ +  ++SPSK LR+
Sbjct:  835 SLSLFFRKVYHLAAVRLRDLCAKLDISDELRKKIWTCFEFSIIQCPELMMDRHLDQLLMCAIYVMAKV-TKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRKRRNSGSSDSRSHQNSPTELNKDRTSRDSSPVMRSSSTLPVPQPSSAPPTPTRLTGANSDMEEEERGDLIQFYNNIYI----KQIKTFAMKY----------------------SQANMDAPPLSPYPF------VRTGSPRRIQLSQNHPVYISPHKNETMLSPREKIFYYFSNSPSKRLRE 1087          
BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Match: sp|Q64700|RBL2_MOUSE (Retinoblastoma-like protein 2 OS=Mus musculus OX=10090 GN=Rbl2 PE=1 SV=3)

HSP 1 Score: 338.191 bits (866), Expect = 4.624e-97
Identity = 205/644 (31.83%), Postives = 344/644 (53.42%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMR-YMQEVIN-----------CGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            Q+ +RFE+LC  L ++   + EAW  Y+ +S +Y ++G+ L WL CALY   RKS  T +  + +  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+GL  D H ++ KA    P V++ +C  +D   ++ K  ++ F++ YI KL EK+++KG+E      L   NF  + + +   Y EY++A+G+ DER++L  +A EE+G+++      + ++  T SA R  M++++            C  + G    ++ +  PC    +T A  + SRL+                    +LS  +   SE+L  +L++ C   P + I  RL ++                    I  Q  Q D +   C  +  +K + +A EM          L YK+     E  + +L ++D+S +L+ D FHR+L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W++ S LWD +     + P+ +EV PP+ +E++
Sbjct:   41 QIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGLSEDCHPKDSKASSDPPCVIEKLCSLHDGLVLEAKGIKEHFWKPYIRKLFEKKLLKGKEENLTGFLEPGNFGESFKAVNKAYEEYVLAAGNLDERVFLGEDAEEEVGTLS----RCLSAASGTESAERTQMRDILQQHLDKSKALRVCTPLTGVRYVQENS--PCVTPVSTAAHSL-SRLH-------------------TMLSGLRNAPSEKLERILRS-CSRDPTQAIADRLKEM------------------YEIYSQHFQPDENFSNCAKEIANKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGVLEHDAFHRSLLACCLEVVAFSHKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVMPPQNLERT 628          

HSP 2 Score: 112.079 bits (279), Expect = 1.556e-23
Identity = 87/303 (28.71%), Postives = 148/303 (48.84%), Query Frame = 1
Query: 2167 KQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTG----GLPTDCKTN--------------------VHTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            +Q+N     +   +   +  SLALFFR +Y+L+ +RLRD+C +L IS +L  KIWT FE  I + T L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  + N+G +        PT+  T+                      ++P    RL        +E R D+ +FYN+++       ++ F + Y                    S +  Q + P LSP P         GS  R ++S +  I++SP   +   SP+ ++ +  ++SPSK LR+
Sbjct:  811 QQQNPGQPLTSSSIRPRKTSSLALFFRKVYYLAGVRLRDLCIKLDISDELRKKIWTCFEFSIIQCTELMMDRHLDQLLMCAIYVMAKV-TKEDRSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSSESRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGASSDVEEEERGDLIQFYNNIY----RKQIQAFAMKY--------------------SQANAQTDTPPLSPYPFVRT-----GSPRRVQLSQSHPIYISPHNNEAMPSPREKIFYYFSNSPSKRLRE 1083          
BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Match: sp|Q64701|RBL1_MOUSE (Retinoblastoma-like protein 1 OS=Mus musculus OX=10090 GN=Rbl1 PE=1 SV=3)

HSP 1 Score: 331.643 bits (849), Expect = 2.659e-95
Identity = 197/625 (31.52%), Postives = 335/625 (53.60%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRK-ATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL-ARSGKAPSIDEVTPPERIE 1959
             + LC +L ++     EA D +  +  NY ++G+ + WL C+LY   RKS    +    ++   VSL R+L  +K+S +QFF ++ KW DM ++ +E R+RIER+E  F VS VIF K+   F +IFQ   +E        ++ ++ C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I +NA++  +++ L N SF+GLPSDFH  ++KA E  P ++  +C+ +D   ++ K  ++ +F+ YI KL +K+++KG     + +L   +F  NS+ +   Y EY++  GDFDERI+L  +A EEIG+          ++D TP      Q  + C         R  A + P  G+        V+            S   + + L ++++  ++  SE+L ++ ++ C  +PM +II  +  +   F   Y  +  D +    I F       ++ R +    +YY  LE I+  E  +                  L+ +D+S LL++D FH++L A C+EIVL    S + FPW++EVL+LQ  +FYK++E+ +R  + L R+MVK+ + + E +++S +W ++S LW++L A + + PS +EV  P   E
Sbjct:   21 LQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEEPPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAPDFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKG-----ECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRK------FTAD-TPFGKLTSQASVECNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVT--------TPVASATQSVSRLQSIVAGLKSAPSEQLLNIFES-CMRNPMGNIIKIVKGIGETFCQHYT-QSTDKQPGSHIDF-------AVNRLKLAEILYYKILETIMVQETRR------------------LHGMDMSVLLEQDIFHKSLMACCLEIVLFAYSSPRTFPWIIEVLDLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWTNNSALWEALHASANRVPSCEEVIFPNNFE 598          

HSP 2 Score: 128.257 bits (321), Expect = 1.656e-28
Identity = 99/300 (33.00%), Postives = 149/300 (49.67%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKT------NVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKR-VTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            R  SLALF+R +Y L+S+RLRD+C +L +S +L  KIWT FE  +     L+KDR +DQ++LC  + + +V       F EI++ YR QPQ+   +YRSVL++S+     +  G    DC+       +   +P  +   +  KE R D+ +FYN V++      VK F + Y +S  +                    ++ P LSP P   +  Q  GS  RRIS   +++VSP K    ++P+  + +  N SPSK L+DIN +I     K K  +   S     P     Q N  VL
Sbjct:  783 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEER-TFQEIMKSYRNQPQANSHVYRSVLLKSIPGGVVVYNG----DCEMTDGDIEDATKTPNCSSEPV--KEERGDLIKFYNTVYV----GRVKSFALKYDLSNQDHI------------------MDAPPLSPFP---HIKQQPGS-PRRISQQHSLYVSPHKNGAGLTPRSALLYKFNGSPSKSLKDINNMIRQGEQKTKKRVIAISGDADSPAKRLCQENDDVL 1049          
BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Match: sp|D3ZS28|RBL1_RAT (Retinoblastoma-like protein 1 OS=Rattus norvegicus OX=10116 GN=Rbl1 PE=1 SV=4)

HSP 1 Score: 329.717 bits (844), Expect = 1.350e-94
Identity = 198/625 (31.68%), Postives = 333/625 (53.28%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRK-ATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL-ARSGKAPSIDEVTPPERIE 1959
             + LC +L ++     EA D +  +  NY ++G+ + WL C+LY   RKS    +    ++   VSL R+L  +K+S +QFF ++ KW DM ++ +E R+RIER+E  F VS VIF K+   F +IFQ   +E        ++ ++ C+ ++LF F W L++  K NF  I  D++ S+ LLLC LD I +NA++  +++ L N SF+GLPSDFH  N+KA E  P ++  +C+ +D   ++ K  ++ +F+ YI KL +K+++KG     + +L   +F  NS+ +   Y EY++  GDFDERI+L  +A EEIG+    A +      LT       Q  ++C         R  A + P  G+        V+            S   + + L ++++  ++  SE+L  + ++ C  +PM +I+  +  +   F   Y  +  D +    I F       ++ R +    +YY  LE I+  E                    +L+ +D+S LL++D FHR+L A C+EIVL    S + FPW+++VL LQ  +FYK++E+ +R  + L R+MVK+ + + E +++S +W ++S LW++L A + K PS +EV  P   E
Sbjct:   21 LQALCQELNLDEGSAAEALDDFTAIRGNYSLEGEVIHWLACSLYVACRKSIIPTVGKGVMEGNCVSLTRILRSAKLSLIQFFSKMKKWMDMSNLPQEFRERIERLERNFEVSTVIFKKFEPIFLDIFQNPYEELPKLPRSRKQRRIPCSVKDLFNFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLIFANAIMCPNRRDLLNPSFKGLPSDFHAVNFKAAEEPPCIIAVLCDLHDGLLVEAKGIKEHYFKPYISKLFDKKILKG-----ECLLDLSSFTDNSKAVNKEYEEYVLTVGDFDERIFLGADAEEEIGTPRKFAADTQFGK-LT------SQASVDCNLQQHFEKKRSFAPSTPLTGRRYLQEKEAVT--------TPVASATQSVSRLQSIVAGLKSAPSEQLLTIFES-CMRNPMGNIVKIVKGIGETFCQHYT-QSTDKQPGSHIDF-------AVNRLKLAEILYYKILETIMVQETR------------------RLHGMDMSVLLEQDIFHRSLLACCLEIVLFAYSSPRTFPWIIDVLGLQPFYFYKVIEVVIRSEEGLSRDMVKHLNSIEEQILESLAWTNNSALWEALRASANKVPSCEEVIFPNNFE 598          

HSP 2 Score: 122.479 bits (306), Expect = 8.945e-27
Identity = 88/263 (33.46%), Postives = 134/263 (50.95%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNT-------GITTGGLPTDCKT-NVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKR-VTFTVNSSPSKELR 2979
            R  SLALF+R +Y L+S+RLRD+C +L +S +L  KIWT FE  +     L+KDR +DQ++LC  + + +V       F EI++ YR QPQ+   +YRSVL++S+            +T G +    KT N  + P         KE R D+ +FYN +++      VK F + Y +S  +                    ++ P LSP P   +  Q  GS  RRIS   +I+VSP K    ++P+  + +  N SPSK+ +
Sbjct:  783 RTGSLALFYRKVYHLASVRLRDLCLKLDVSNELRRKIWTCFEFTLVHCPDLMKDRHLDQLLLCAFYIMAKVTKEER-TFQEIMKSYRNQPQANSHVYRSVLLKSIPGEVVAYNGDYEMTDGDIEDATKTPNCSSEP--------VKEERGDLIKFYNAIYV----GRVKSFALKYDLSNQDHI------------------MDAPPLSPFP---HIKQQPGS-PRRISQQHSIYVSPHKNASGLTPRSALLYKFNGSPSKKAK 1010          
BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Match: sp|O55081|RBL2_RAT (Retinoblastoma-like protein 2 OS=Rattus norvegicus OX=10116 GN=Rbl2 PE=1 SV=1)

HSP 1 Score: 330.872 bits (847), Expect = 1.766e-94
Identity = 198/640 (30.94%), Postives = 335/640 (52.34%), Query Frame = 1
Query:   91 QLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQ-KIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNAL-ISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMR-YMQEVIN-------CGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRC--QTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLA-RSGKAPSIDEVTPPERIEQS 1965
            Q+ +RFE+LC  L ++   + EAW  Y+ +S +Y ++G+ L WL CALY   RKS  T +  + +  YVSL R+L  S+ S ++FF+++ KW DM ++    R+R ER+E  F+VSAVIF KY   F +IF+   +E    Q   ++ +  CT  E+F F W+L+I  K NFP I  D++ S+ LLLC LD +  NAL  S  K+L N +F+G+  D H R+       P V++ +C  +D   ++ K  +  F++ YI KL EK++++G+E      L   NF  + + +   Y EY++A+G  DERI+L  +A EE+G+ +   +    +     + MR  +Q+ ++       C  + G    ++ +  PC    +T    +                    N L  +L+  +   SE+L  +L++ C   P   I  RL ++                    I  Q  Q D ++  C  +  +K + +A EM          L YK+     E  + +L ++D+S +L++D FH++L A C+E+V        +FP++ E+ ++   HFYK++E+F+R  D L RE+VK+ +Q+ E ++D  +W++ S LWD +     + P+ +EVTPP  +E++
Sbjct:   41 QIQQRFEELCSRLNMDEAARAEAWSSYRSMSESYTLEGNDLHWLACALYVACRKSVPTVSKGTAEGNYVSLTRILRCSEQSLIEFFNKMKKWEDMANLPPHFRERTERLERNFTVSAVIFKKYEPIFQDIFKYPQEEQPRQQRGRKQRRQPCTTSEIFHFCWVLFIYAKGNFPMISDDLVNSYHLLLCALDLVYGNALQCSNRKELVNPNFKGVSEDGHPRDSHPSSDPPCVIEKLCSLHDGLVLEAKGIKQHFWKPYIRKLFEKKLLRGKEENLTGFLEPGNFAESFKAVNKAYEEYVLATGSLDERIFLGEDAEEEVGTFSRCVSAASGTESAERTQMRDILQQHLDKSKTLRVCNPLTGVRYVQENS--PCVTPVSTATHSL--------------------NRLHTMLAGLRNAPSEKLEQILRS-CSRDPTRAIADRLREM------------------YEIYSQHFQPDENVSNCAKEMANKHFRFA-EM----------LYYKVLESVIEQEQKRLGDMDLSGVLEQDAFHKSLLACCLEVVAFSYKPPGNFPFIAEIFDVPHYHFYKVIEVFIRAEDGLCREVVKHLNQIEEQILDHLAWKTKSPLWDRIRDNENRVPTCEEVTPPHNLERT 628          

HSP 2 Score: 115.546 bits (288), Expect = 1.455e-24
Identity = 82/283 (28.98%), Postives = 142/283 (50.18%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGI----TTGGLPTDCKTN--------------------VHTSPGGTQRLIRT-----KEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            SL+LFFR +Y+L+ +RLRD+C +L IS +L  KIWT FE  I +   L+ DR +DQ+++C I+ + +V +  + +F  I++ YR QPQ+  ++YRSVLI+  + N+G     +    PT+  T+                      ++P    RL        +E R D+ +FYN+++   +  +  ++                        S +  Q++ P LSP P         GS  R ++S +  I++SP K +  +SP+ ++ +  ++SPSK LR+
Sbjct:  831 SLSLFFRKVYYLAGVRLRDLCTKLDISDELRKKIWTCFEFSIVQCPELMMDRHLDQLLMCAIYVMAKV-TKEDKSFQNIMRCYRTQPQARSQVYRSVLIKGKRRNSGSCENRSHQNSPTELNTDRASRDSSPVMRSNSTLPVPQPSSAPPTPTRLTGANSDIEEEERGDLIQFYNNIYRKQIQTFAMKY------------------------SQANSQMDTPPLSPYPFVRT-----GSPRRVQLSQSHPIYISPHKNEAMLSPREKIFYYFSNSPSKRLRE 1083          
BLAST of retinoblastoma-like protein vs. TrEMBL
Match: K9MXG1 (Retinoblastoma-like protein OS=Schmidtea mediterranea OX=79327 GN=Rb PE=2 SV=1)

HSP 1 Score: 2097.4 bits (5433), Expect = 0.000e+0
Identity = 1033/1034 (99.90%), Postives = 1033/1034 (99.90%), Query Frame = 1
Query:   52 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 3153
            MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQ QSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ
Sbjct:    1 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQQQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 1034          
BLAST of retinoblastoma-like protein vs. TrEMBL
Match: D2DJU6 (Rb-like protein OS=Schmidtea mediterranea OX=79327 PE=2 SV=1)

HSP 1 Score: 2051.56 bits (5314), Expect = 0.000e+0
Identity = 1016/1034 (98.26%), Postives = 1018/1034 (98.45%), Query Frame = 1
Query:   52 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 3153
            MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGV+FNNYDSRVINSNYLIALLSKRQAYASEELT MLQTHCF+SPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKL               MYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ
Sbjct:    1 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVSFNNYDSRVINSNYLIALLSKRQAYASEELTGMLQTHCFYSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKL---------------MYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 1019          
BLAST of retinoblastoma-like protein vs. TrEMBL
Match: A0A504YXB4 (Putative retinoblastoma protein OS=Fasciola gigantica OX=46835 GN=FGIG_07316 PE=4 SV=1)

HSP 1 Score: 700.279 bits (1806), Expect = 0.000e+0
Identity = 415/1084 (38.28%), Postives = 600/1084 (55.35%), Query Frame = 1
Query:   85 EEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDF-----HNRNWKAPERFPT-VLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIK-GRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRA--NEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLS----LLFLSA-YNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKM--------RSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLI-CSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVE--------------------SNRER---TVTKSSMITGRRLGTSAPLNQNIQN-SQGSFRHEDDESARAAAQLLSA--NDDEKQEN-------------------------------------------VEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGS-NVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGST-------------------SRRISNNKNIFVSPAK----TQITMSPKRVTFTVNSSPSKELRD 2982
            EE + KRFEDLC DLCIE +++EEAW+KYK+V  NY +DGDQLQWLVC+LYEC R+S +D++    ++N YVSL+RLLS +KMS VQFFHRI KWADM DM +++RDR+E +E QF+VS+VIF  +   F  +F         + + E      T  +LFR TWLL+IK + NFPA+  D++ S+ LL C LDWI    ++S+   + N    GLP +F         W  P   P  +L+ ICE N++NY++CK+ ++ FF+ +I +L+EK++IK        ++L   NF+   + + N Y EY++ +GDFDERIYL PNA EEIGS +     + + LSSDL PSA RYM E+ N G   G  +T +       GK N   +G VSRLNGG+NFNN ++R  N N L  LL+ R    S  L D++Q+HC  SP+E++ + LD+L+    L+++ A Y        +   +     Q     QR     ++YY ALE IL  E+ ++E R              NS+   +K    D+S LL ++ FHR+L++ C+E+V+I C    +HFPW+LE L L+A+HF+K++E+ +R VDLPR++VKY +QV E ++DSY+WRS S LW ++  +G+APSI+EV PPER+EQS       L  E                    S + R   + T  S+I  R  G         ++ S G+  H +DESA A AQLL++   D E   N                                           V    +    Y  R DSLA+FFR +Y ++S+RLRD+CDRL++ RD++ K+WT  EH I  ET LL+DRC+DQ+ILC ++ V +    R L F +I+Q+YRMQPQS R+IYR VLI  V    GI  G                        E R D++RFYN VFLP +  ++++    Y  S + +  ++L    S      S    +QP ++P+P+  +    +  T                   +RR+++N+N+F+SP K     Q+T+SPKRV FT+  S  K+L+D
Sbjct:    9 EEPIEKRFEDLCQDLCIEGSIREEAWEKYKDVWANYSVDGDQLQWLVCSLYECCRRSISDSLAGHVVENAYVSLSRLLSAAKMSMVQFFHRIRKWADMTDMIDDMRDRVELLERQFAVSSVIFRNFGRSFGVLFH--------EPVFEDNSDNPTTADLFRLTWLLFIKSRANFPAVTDDLVNSYHLLACCLDWILGAVMVSRRSDMINLELTGLPKEFLTAVSQKNTWCPPHELPPCMLRLICEDNEVNYVECKTVKEHFFKPFIARLIEKDLIKLNPPLIYGSILEPDNFDITLQNLNNNYEEYIIGTGDFDERIYLTPNAAEEIGSASQSGVQSNLALSSDLAPSARRYMLELSNIG-FGGFTETNRR------GKAN---AGAVSRLNGGINFNNPEARNQNLNQLQILLAGRSKEPSAALVDLIQSHCSVSPLEEMQSHLDELAAEFQLMYVRADYLPSSTGSGSPDELALSAAQ-----QRVYLGLQLYYLALESILMDEVRRMEKRMNACAGSAVIADGMNSQGRRVK---PDLSGLLTQEIFHRSLFSCCMELVMISCDPPERHFPWILEALNLEALHFFKVIEVLVRNVDLPRDVVKYMNQVGELILDSYAWRSLSPLWAAIKAAGRAPSIEEVVPPERLEQSGFSRPGALPSEQLKTTASSTQNVMIRHGPTPSKQARLLASATSGSLIRSRPSGEHGSTVSTARHISTGA--HVEDESAEATAQLLASGVGDIETDANSNLLSGPTEEVTLTEGVSALTKRGTAAAGATNVLNTNSGSWSRVNPGNAPMKFYPTRRDSLAIFFRQLYMIASVRLRDLCDRLNVQRDVLAKVWTCVEHAIVHETELLRDRCLDQIILCALYGVCKTMLYRQLTFIDIIQVYRMQPQSHRDIYRRVLINVVA--YGINHG------------------------EDRGDLSRFYNVVFLPHMTQFLRKVTSTYNQSDTGDRGLTLASGGSTTDNLWS----DQPSMAPLPVYPSLPPTMAGTVLGNVLNASSATGSAEVSQARRLASNRNVFISPVKQPSQQQLTISPKRVVFTIGRSSGKDLQD 1034          
BLAST of retinoblastoma-like protein vs. TrEMBL
Match: A0A4E0S287 (Retinoblastoma protein 1 OS=Fasciola hepatica OX=6192 GN=D915_003614 PE=4 SV=1)

HSP 1 Score: 681.019 bits (1756), Expect = 0.000e+0
Identity = 416/1107 (37.58%), Postives = 603/1107 (54.47%), Query Frame = 1
Query:   85 EEQLGKRFEDLCVDLCIESTVKEEAWDKYK----------EVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQ-----------FFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDF-----HNRNWKAPERFPT-VLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIK-GRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRA--NEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLS----LLFLSA-YNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNN----------IDISALLKKDEFHRALYAICVEIVLI-CSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVE--------------------SNRER---TVTKSSMITGRRLGTSAPLNQNIQN-SQGSFRHEDDESARAAAQLLSA--NDDEKQEN-------------------------------------------VEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGS-NVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNF-----DQILG--------------STSRRISNNKNIFVSPAK----TQITMSPKRVTFTVNSSPSKELRD 2982
            EE + KRFEDLC DLCIE +++EEAW+KYK          +V  NY +DGDQLQWLVC+LYEC R+S +D++    ++N YVSL+RLLS +KMS VQ           FFHRI KWADM DM +++RDR+E +E QF+VS+VIF  +   F  +F         + + E      T  +LFR TWLL+IK + NFPA+  D++ S+ LL C LDWI    ++S+   + N    GLP +F         W  P   P  +L+ ICE N++NY++CK+ ++ FF+ ++ +L+EK++IK        ++L   NF+   + + N Y EY++ +GDFDERIYL PNA EEIGS +     + + LSSDL PSA RYM E+ N G   G  +T +       GK N   +G VSRLNGG+NFNN ++R  N N L  LL+ R    S  L D++Q+HC  SP+E++ + LD+L+    L+++ A Y        +   +     Q     QR     ++YY ALE IL  E+ ++E R      N+ AG   + +           D+S LL ++ FHR+L++ C+E+V+I C    +HFPW+LE L L+A+HF+K++E+ +R VDLPR++VKY +QV E ++DSY+WRS S LW ++  +G+APSI+EV PPER+EQS       L  E                    S + R   + T  S+I  R  G         ++ S G+  H +DESA A AQLL++   D E   N                                           V    +    Y  R DSLA+FFR +Y ++S+RLRD+CDRL++ RD++ K+WT  EH I  ET LL+DRC+DQ+ILC ++ V +    R L F +I+Q+YRMQPQS R+IYR VLI  V    GI  G                        E R D++RFYN VFLP +  ++++    Y  S + +  ++L    S      S    +QP ++P+P+  +        +LG              S +RR+++N+N+F+SP K     Q+T+SPKRV FT+  S  K+L+D
Sbjct:    9 EEPIEKRFEDLCQDLCIEGSIREEAWEKYKGNLLDLFFMSDVWANYSVDGDQLQWLVCSLYECCRRSISDSLAGHVVENAYVSLSRLLSAAKMSMVQVEVKKIMIVVQFFHRIRKWADMTDMIDDMRDRVELLERQFAVSSVIFRNFGRSFGVLFH--------EPVFEDNSDNPTTADLFRLTWLLFIKSRANFPAVTDDLVNSYHLLACCLDWILGAVMVSRRSDMINLELTGLPKEFLTAVSQKNTWCPPHELPPCMLRLICEDNEVNYVECKTVKEHFFKPFMARLIEKDLIKLNPPLIYGSILEPDNFDITLQNLNNNYEEYIIGTGDFDERIYLTPNAAEEIGSASQSGVQSNLALSSDLAPSARRYMLELSNIG-FGGFTETNRR------GKAN---AGAVSRLNGGINFNNPEARNQNLNQLQILLAGRSKEPSAALVDLIQSHCSVSPLEEMQSHLDELAAEFQLIYVRADYLPSSTGSSSPDELALSAAQ-----QRVYLGLQLYYLALESILMDEVRRMEKRM-----NACAGSTVIADGMTSQGRRVKPDLSGLLTQEIFHRSLFSCCMELVMISCDPPERHFPWILEALNLEALHFFKVIEVLVRNVDLPRDVVKYMNQVGELILDSYAWRSLSPLWAAIKAAGRAPSIEEVVPPERLEQSGFSRPGALPSEQLKTTASSTQNVMIRHGPTPSKQARLLASATSGSLIRSRPSGEHGSTVSTARHISTGA--HVEDESAEATAQLLASGVGDIETDANSNLLSGPTEEVTLTEGVSALTKRGTATAGATNVLNTNSGSWSRVNPGNAPMKFYPTRRDSLAIFFRQLYMIASVRLRDLCDRLNVQRDVLVKVWTCVEHAIVHETELLRDRCLDQIILCALYGVCKTMLYRQLTFIDIIQVYRMQPQSHRDIYRRVLINVVA--YGINHG------------------------EDRGDLSRFYNVVFLPHMTQFLRKVTSTYNQSDTGDRGLTLASGGSTTDNLWS----DQPSMAPLPVYPSLPPAIAGTVLGNVLNASSATGSAEVSQARRLASNRNVFISPVKQPSQQQLTISPKRVVFTIGRSSGKDLQD 1055          
BLAST of retinoblastoma-like protein vs. TrEMBL
Match: A0A5K3EXX9 (Uncharacterized protein OS=Mesocestoides corti OX=53468 PE=4 SV=1)

HSP 1 Score: 595.89 bits (1535), Expect = 0.000e+0
Identity = 364/1026 (35.48%), Postives = 560/1026 (54.58%), Query Frame = 1
Query:   79 DQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTD-EELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSK---QLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSD-LTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQ-THCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLI-C-SDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSG---KAPSIDEVTPPERIEQSF--KQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSH--------KLVYS-----IRHDSLALFFRHMYFLSSLRLRDICDRLHISRD-LMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVAS----SRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-------IRNNFDQILGST---------SRRISNNKNIFVSPAKTQI-----------TMSPKRVTFTVNSSPSKEL 2976
            +++E + KRFEDLC  LCIE  V+EEAWDKYK+V TNY IDGDQLQWLVC+LYEC R+ TTD+I+   ++N YVSL RLL+ +KMS VQFFHRI KW+DM +M++E+ DRIER+E QF++S+V F  +   F   F+ +      Q  E K   +C +  E+FRF WL++IK + NFPA+  D++ SF LL C +DW+  N L++       L NS +RG        N   P   P +L+FICE N +N+++CK+ ++ FF  YI +L+EK+++K   +         +F    + I + Y EY++ +GDFDERI+L+PNA +EIGS     +    + D L+P         +N G   GS+    A   P           V+  L+G V+ N+ ++R  N +++ ALLS R    S  L ++++ T    +P+ DI TRL  +S  FLSAY               + +  + +  R Q   + YYYALE IL  E +    R   +   + AG           +L+ D FHRALYA C+E+V++ C  D  + FPW+LE L L ++ FYK+VE+F++ ++LPRE+VKY +++ E ++D ++WR+ S+LW++  ++G     P+++E+ PPE+++++   + G ++L+        VT +  I  +  G ++P  +    S     H+D+ +  AA+ L +   +                    + ++S     +R DS+A+FFRH+Y L++ RLR +CDR+  +   LM + WT FEH +  E+ L KDR +DQ++LCC++ V++  +    SR +   EI+Q YRMQPQ+TR+ YR VLI  V T                     GG+   + + E R D+ RFYN VFL  +  ++++F        ++ S ++  P              QP L+PMP       + +N       T         +RR++NN N+F+SP K              T+SPKRVTFTV    SKEL
Sbjct:    5 NEDEPIEKRFEDLCQILCIEGAVREEAWDKYKDVWTNYSIDGDQLQWLVCSLYECCRRPTTDSISGQVMENAYVSLTRLLATAKMSMVQFFHRIRKWSDMTEMSDEMHDRIERLERQFAISSVTFRHFTRAFPVYFRSLISEDVPQ--EHKLDNVCPEVSEVFRFIWLMFIKTRANFPAVADDLVNSFYLLACCIDWMVGNILVAGQACCHALLNSEYRG--GKCFPTNVDTP---PCLLRFICEDNGINFVECKAIKEHFFHPYISRLVEKDMLKLHPSGPIGFFQPEDFAHALQRINDHYEEYVLGTGDFDERIFLSPNASQEIGSARPPGSGDSKTGDQLSPG-----DGGLNSGLYMGSIRPDSALYGP-----------VLGNLSGFVSLNSPETRSQNLHHIQALLSGRSRNPSGALFELIRSTATNETPLTDIRTRLQSVSEQFLSAYTAG------------EPRAIESASHRSQLAEQFYYYALEQILTDEKTAKATRPPQQPSAAIAG-----------ILRSDAFHRALYACCLELVIVNCEGDEDRRFPWLLEALTLDSIAFYKVVEVFIKNIELPREIVKYLNRIVERILDQFAWRTGSSLWNTNQQTGTRTAIPTVEEIFPPEKLDENMVSRYGRRELL--------VTTAPGIQQQTSGGASPAKKIRLGSHHQQPHQDESARAAASLLAATEGETGAGGGVGGGVEEGADGGDSRAIWSAPPPPLRRDSMAIFFRHVYQLAAGRLRAVCDRIQSAPPLLMSRAWTAFEHAVVNESDLFKDRLLDQILLCCLYGVSKAGAVGPNSRVVTLVEIVQAYRMQPQATRDTYRRVLICRVATR--------------------GGS---VESVEERGDLARFYNLVFLSRMDRFLQQF--------ASPSSAVGAPK------------QQPLLTPMPAQPYSQNVHSNLQTAQTPTAGVSEGFLPARRLTNNHNVFISPVKRHPQPVHHPPTGTHTLSPKRVTFTVGKGTSKEL 933          
BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Match: rbl1 (RB transcriptional corepressor like 1 [Source:NCBI gene;Acc:103024081])

HSP 1 Score: 344.354 bits (882), Expect = 3.536e-101
Identity = 302/1070 (28.22%), Postives = 481/1070 (44.95%), Query Frame = 1
Query:  100 KRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFN-SRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHN-----------TVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFS----QVSENLV---DSYSWR--------------------SDSTLWDSLARSGKAPSI-----DEVTPP------ERI----EQSFKQGNK------KLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVL----IESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRV-TFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            +R E LC +L ++    EEA + +  +   Y ++G+ + WL CALY   RK++   +    ++   VSL R+L  SK+S +QFF ++ KWADM ++ ++ R+RI  +E  F VS VIF K+   F ++FQ             K + L C   ++F+F W L++  K NF  I  D++ S+ LLLC LD +  NAL+  +K+ L N  FRG P D       + E  P+V++ +CE +D   ++ K  ++ +F+ YI +L EK +          +   V F F  S+ I   Y EY++  GDFDER++L  +A EEIG+    A E        P  +    +V N            A + P  G+             + A+  VSRL   V       R   S+ L+ + S                 C   P + I+ R+  L   F   Y  +  D              D +  R +    +YY  LE ++  E  +++ +                  D++ LL++D FH +L A C+E+VL    S + FPW++E   L+  +FYK++E+F+R  + L R+MVK+ +    QV E++    DS  W                     S S +  +L      PS      D  + P       R+     Q      K      KLI   + E + T ++      L  SAP    +   Q S     D +      LL++           +T  +     R  SLALFFR +Y L+S+RLRD+C +L IS +L  KIWT FEH +   T ++KDR +DQ++LC ++ +++++   +  F +I++ YR QPQ+T  +YRSVL    I   + +  +       +CK         T+    ++E R D+ +FYN V++      +K F + Y +                  SS+  ++  P LSP P +R    Q L  + RRIS   +I++SP K    ++P    T+  + SPSKEL DIN +I       K   +    +   PT   +Q +  VL
Sbjct:   21 ERLEALCQELNMDEETAEEALENFTSIWNTYTLEGEVVHWLACALYAACRKASIPTVGRGLVEGNCVSLTRILRSSKLSLIQFFSKMKKWADMSNLLQDFRNRISHLERNFEVSTVIFRKFEPIFLDMFQNPQGEPPRVPRGRKHRRLPCHISDVFKFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLVYGNALLCANKKDLVNPLFRGFPKD-----SVSSEEPPSVIEELCELHDGLVVEAKGIKEHYFKPYIRRLFEKRLF---------LTVCVYFLFFFSKAINREYEEYVLTVGDFDERVFLGADADEEIGTPRKTAAEP------PPGQLTARMQVENNLQQHFEKTRSLAPSTPLTGRRYLKEKELLITPVSSATQSVSRLQSMVT----GLRNAPSDALLQIFSS----------------CSRCPTDMILNRVKTLGETFKENYTKQTED--------LPGAHIDFAENRLKLAEILYYKILESVMTQETKRLQGK------------------DMTGLLEQDVFHCSLLACCLEVVLFAYSSQRTFPWIIETFHLRPFYFYKVIEVFIRSEEGLSRDMVKHLNTIEEQVLESMAWTKDSVLWDTLHNANNKVPTVEEFNSYSISHSLINQTLLSPSDVPSSPISAHDRFSSPTAGSVKRRLFGDDPQPLSPVKKISFTPIKLIPSPSTENSQTANTTTV---LSMSAPNGITVIQVQAS-----DLNPLTTQVLLASPTRAPAPPPTTDTQQQASRPRRTGSLALFFRKVYHLASVRLRDLCLKLDISAELRGKIWTCFEHSLVHCTDMMKDRHLDQLLLCSVYIISKISKEVH-TFQDIMKCYRSQPQATSHVYRSVLIRRRIREQQADENMDVDPPADECKDT-------TEADSESEEDRGDLIQFYNSVYV----MKMKTFALKYAL------------------SSADNRMEAPPLSPFPSVRA---QPL--SPRRISQRHSIYLSPHKNGSCLTPNSAYTYKFSGSPSKELSDINRMIRQGGVSKKRAFTMEGDETESPTKRLNQESEDVL 981          
BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Match: rbl2 (RB transcriptional corepressor like 2 [Source:NCBI gene;Acc:103033933])

HSP 1 Score: 329.717 bits (844), Expect = 2.219e-95
Identity = 204/644 (31.68%), Postives = 334/644 (51.86%), Query Frame = 1
Query:   43 IFYMTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHG-GQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL-ARSGKAPSIDEVTPPERIE 1959
            I     +N++ ED  ++  + FEDLC  L ++      AW  Y+ +S NY ++G +L WL CALY   R S  T +  + +  YVSL R+L  S+ S ++FF ++ KW DM ++  E R   +++E  F+V+AVIF KY+  F +IF+   E         ++ +  CT  E+F F W+L++  K NFP I  D++ S+ LLLC LD + SN+L+ S  K L N SFRGLP DF ++++K P      ++ +CE +D   ++ K  ++ F++ +I++L E++++KG+E      L  VNF  +   +  +Y E++++SG  DERI+L   A E+IG+      E + + +  P+++ Y     +   V   +  R    +  AG   ++A   V RL+                 L+A L  R    S  L ++L+  C   P E I  RL ++S  FL  Y  K  + +   R        D + +  +    +YY ALE I+  E                  + +L + D+S++L++D  HR+L A C+EIV+        F  VL+V E+   HFYK++E+ +R  + L RE VK+ + V E +++S +W+  S LWDS+       PS  EV PP+ +E
Sbjct:   12 ILNCVKMNEE-EDALQKTRQGFEDLCRALNMDEEASNGAWRSYENISKNYTLEGSELHWLACALYVACRTSVPTVSKGTAEGNYVSLTRILRSSEQSLIEFFSKMKKWQDMANLPREFRQSTDKLERNFTVTAVIFKKYVPIFKDIFKTPSEEPARAHRSRKQRRHPCTVAEVFHFCWVLFVHAKGNFPMISDDLVNSYHLLLCALDLVYSNSLLCSNRKDLLNPSFRGLPEDFSSKDYK-PSGPVCFIEQLCELHDGLVLEAKGVKEHFWKPFIKRLFERKILKGKEEILTGFLDPVNFGDSLTSLNRVYEEHILSSGALDERIFLGEGAKEDIGTPGPCLCEGIENQE-HPASILYNSLTSSALKVSTPLTGRTYVQESSAGTPVSMAMQGVGRLHS----------------LLAGLKHR---PSLRLREILKA-CARDPTEGIAGRLREMSEAFLQNYETKQEENEVLAR--------DIAAKYFRLAEALYYKALEGIIDHE------------------KRRLGDSDLSSILEQDMLHRSLIACCLEIVIFSYRPPGEFQRVLQVFEIPPYHFYKVIEVLVRAEEGLFREAVKHLNHVEEQVLESLAWKETSPLWDSIKGAKNHVPSCQEVMPPQYLE 606          

HSP 2 Score: 122.865 bits (307), Expect = 8.074e-28
Identity = 92/288 (31.94%), Postives = 146/288 (50.69%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI-----------ESVKTNTGITTGG--------------------LPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            R  SL+LFFR +Y L+S+RLRD+C +L IS +L  KIWT FE+ +   T L+ DR +DQ+++C I+ +T+V +  + +F  I++ YR QPQ++  +YRSVLI           E+    T  + GG                     P+   +    +PG      + +E R D+ RFYNHV++      +K F + Y                    SSS P+   P L P P+       +GS  R  +S+N +I++SP K+   ++PK ++ + ++SSPS  LR+
Sbjct:  784 RTGSLSLFFRKVYHLASVRLRDLCVKLDISTELRQKIWTCFEYSLVHCTELMIDRHLDQLLMCAIYVMTKV-TKEDKSFQNIMKCYRSQPQASSSVYRSVLISRRKRRQSGNNENSNRQTSPSEGGHEQGSGGSSPMRSSSTLPIPQPSSTPSTPTHAPGAPPE--QEEEERGDLIRFYNHVYI----KQIKPFALRY--------------------SSSSPK--TPPLCPYPLLR-----IGSPRRVLLSHNHSIYISPHKSGSPLTPKDKIFYYISSSPSNRLRE 1037          
BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Match: rbl2 (RB transcriptional corepressor like 2 [Source:NCBI gene;Acc:103033933])

HSP 1 Score: 329.331 bits (843), Expect = 2.504e-95
Identity = 202/636 (31.76%), Postives = 331/636 (52.04%), Query Frame = 1
Query:   67 DDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKST-TDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHG-GQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL-ARSGKAPSIDEVTPPERIE 1959
            ++ ED  ++  + FEDLC  L ++      AW  Y+ +S NY ++G +L WL CALY   R S  T +  + +  YVSL R+L  S+ S ++FF ++ KW DM ++  E R   +++E  F+V+AVIF KY+  F +IF+   E         ++ +  CT  E+F F W+L++  K NFP I  D++ S+ LLLC LD + SN+L+ S  K L N SFRGLP DF ++++K P      ++ +CE +D   ++ K  ++ F++ +I++L E++++KG+E      L  VNF  +   +  +Y E++++SG  DERI+L   A E+IG+      E + + +  P+++ Y     +   V   +  R    +  AG   ++A   V RL+                 L+A L  R    S  L ++L+  C   P E I  RL ++S  FL  Y  K  + +   R        D + +  +    +YY ALE I+  E                  + +L + D+S++L++D  HR+L A C+EIV+        F  VL+V E+   HFYK++E+ +R  + L RE VK+ + V E +++S +W+  S LWDS+       PS  EV PP+ +E
Sbjct:    2 NEEEDALQKTRQGFEDLCRALNMDEEASNGAWRSYENISKNYTLEGSELHWLACALYVACRTSVPTVSKGTAEGNYVSLTRILRSSEQSLIEFFSKMKKWQDMANLPREFRQSTDKLERNFTVTAVIFKKYVPIFKDIFKTPSEEPARAHRSRKQRRHPCTVAEVFHFCWVLFVHAKGNFPMISDDLVNSYHLLLCALDLVYSNSLLCSNRKDLLNPSFRGLPEDFSSKDYK-PSGPVCFIEQLCELHDGLVLEAKGVKEHFWKPFIKRLFERKILKGKEEILTGFLDPVNFGDSLTSLNRVYEEHILSSGALDERIFLGEGAKEDIGTPGPCLCEGIENQE-HPASILYNSLTSSALKVSTPLTGRTYVQESSAGTPVSMAMQGVGRLHS----------------LLAGLKHR---PSLRLREILKA-CARDPTEGIAGRLREMSEAFLQNYETKQEENEVLAR--------DIAAKYFRLAEALYYKALEGIIDHE------------------KRRLGDSDLSSILEQDMLHRSLIACCLEIVIFSYRPPGEFQRVLQVFEIPPYHFYKVIEVLVRAEEGLFREAVKHLNHVEEQVLESLAWKETSPLWDSIKGAKNHVPSCQEVMPPQYLE 589          

HSP 2 Score: 124.405 bits (311), Expect = 2.655e-28
Identity = 91/290 (31.38%), Postives = 146/290 (50.34%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI-----------ESVKTNTGITTGG----------------------LPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSR-RISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSKELRD 2982
            R  SL+LFFR +Y L+S+RLRD+C +L IS +L  KIWT FE+ +   T L+ DR +DQ+++C I+ +T+V +  + +F  I++ YR QPQ++  +YRSVLI           E+    T  + GG                       P+   +    +PG      + +E R D+ RFYNHV++      +K F + Y                  S SS + +   P L P P+       +GS  R  +S+N +I++SP K+   ++PK ++ + ++SSPS  LR+
Sbjct:  767 RTGSLSLFFRKVYHLASVRLRDLCVKLDISTELRQKIWTCFEYSLVHCTELMIDRHLDQLLMCAIYVMTKV-TKEDKSFQNIMKCYRSQPQASSSVYRSVLISRRKRRQSGNNENSNRQTSPSEGGHEQATGSGGSSPMRSSSTLPIPQPSSTPSTPTHAPGAPPE--QEEEERGDLIRFYNHVYI----KQIKPFALRY------------------SSSSPKAEAETPPLCPYPLLR-----IGSPRRVLLSHNHSIYISPHKSGSPLTPKDKIFYYISSSPSNRLRE 1026          
BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Match: rbl1 (RB transcriptional corepressor like 1 [Source:NCBI gene;Acc:103024081])

HSP 1 Score: 302.368 bits (773), Expect = 5.807e-86
Identity = 189/630 (30.00%), Postives = 309/630 (49.05%), Query Frame = 1
Query:  100 KRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHN-----------TVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARS-GKAPSIDEV 1938
            +R E LC +L ++    EEA + +  +   Y ++G+ + WL CALY   RK++   +    ++   VSL R+L  SK+S +QFF ++ KWADM ++ ++ R+RI  +E  F VS VIF K+   F ++FQ             K + L C   ++F+F W L++  K NF  I  D++ S+ LLLC LD +  NAL+ +  K L N  FRG P D       + E  P+V++ +CE +D   ++ K  ++ +F+ YI +L EK ++KG E     +L + NF+ N++ I   Y EY++  GDFDER++L  +A EEIG+    A E        P  +    +V N            A + P  G+             + A+  VSRL   V       R   S+ L+ + S                 C   P + I+ R+  L   F   Y  +  D              D +  R +    +YY  LE ++  E  +++ +                  D++ LL++D FH +L A C+E+VL    S + FPW++E   L+  +FYK++E+F+R  + L R+MVK+ + + E +++S +W  DS LWD+L  +  K P+++EV
Sbjct:   21 ERLEALCQELNMDEETAEEALENFTSIWNTYTLEGEVVHWLACALYAACRKASIPTVGRGLVEGNCVSLTRILRSSKLSLIQFFSKMKKWADMSNLLQDFRNRISHLERNFEVSTVIFRKFEPIFLDMFQNPQGEPPRVPRGRKHRRLPCHISDVFKFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLVYGNALLCANKKDLVNPLFRGFPKD-----SVSSEEPPSVIEELCELHDGLVVEAKGIKEHYFKPYIRRLFEKRILKGDEETLTELLDTPNFQDNNKAINREYEEYVLTVGDFDERVFLGADADEEIGTPRKTAAEP------PPGQLTARMQVENNLQQHFEKTRSLAPSTPLTGRRYLKEKELLITPVSSATQSVSRLQSMVT----GLRNAPSDALLQIFSS----------------CSRCPTDMILNRVKTLGETFKENYTKQTED--------LPGAHIDFAENRLKLAEILYYKILESVMTQETKRLQGK------------------DMTGLLEQDVFHCSLLACCLEVVLFAYSSQRTFPWIIETFHLRPFYFYKVIEVFIRSEEGLSRDMVKHLNTIEEQVLESMAWTKDSVLWDTLHNANNKVPTVEEV 593          

HSP 2 Score: 119.783 bits (299), Expect = 6.443e-27
Identity = 98/301 (32.56%), Postives = 153/301 (50.83%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI------ESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRV-TFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVL 3096
            R  SLALFFR +Y L+S+RLRD+C +L IS +L  KIWT FEH +   T ++KDR +DQ++LC ++ +++++   +  F +I++ YR QPQ+T  +YRSVLI      +    N  +     P D   +        +    ++E R D+ +FYN V++      +K F + Y +                  SS+  ++  P LSP P +R    Q L  + RRIS   +I++SP K    ++P    T+  + SPSKEL DIN +I       K   +    +   PT   +Q +  VL
Sbjct:  770 RTGSLALFFRKVYHLASVRLRDLCLKLDISAELRGKIWTCFEHSLVHCTDMMKDRHLDQLLLCSVYIISKISKEVH-TFQDIMKCYRSQPQATSHVYRSVLIRRRIREQQADENMDVDP---PADESNDRTELAARAEADSESEEDRGDLIQFYNSVYV----MKMKTFALKYAL------------------SSADNRMEAPPLSPFPSVRA---QPL--SPRRISQRHSIYLSPHKNGSCLTPNSAYTYKFSGSPSKELSDINRMIRQGGVSKKRAFTMEGDETESPTKRLNQESEDVL 1039          
BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Match: rb1 (retinoblastoma 1 [Source:ZFIN;Acc:ZDB-GENE-040428-1])

HSP 1 Score: 131.724 bits (330), Expect = 1.178e-30
Identity = 172/832 (20.67%), Postives = 338/832 (40.62%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKY--KEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVD-MNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGL---PSDFHNRNWKAPERFP----TVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNS-RGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLIC----------SDSSKH---FPWVLEVLELQAVHFYKIVEIFMRC-VDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISR-DLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLI 2523
            F  LC +L + +TV   AW  +    +S     + ++  W VC     V          L+    +  +LL    +   QF   + K  + VD ++ E+   + ++E ++ VS  ++ ++                G+            +EL R +W++++  K +   +  D+++SFQ+LLC L++       +  + L+ S+       P    +R  KA  R P     +L+ +C+ +D +  + K+   S F  +++ L     + G +            EF +   +   Y E    + DFD R++L+ +  E +  V   A ++    ++ P   +  +E +    VP     R              A   + +L GG+      S   + N ++                    +C   P E+I  R+ +L  +F   +                    +   QRC+   K  +             ++L YK+     ++ E +L+  + S LL    FH +L A  +E+VL            S+S +    FPW+L+V +L A  FYK++E F++    L  +M+++  +    +++S +W++DS L++ L +S +    ++  PP  + Q  +  +            +  S +   R+L  +A           +   E D  A   +Q  +    +                 R +SL+LF++ +Y ++ LRL+ +   L  S  +L   IWT  +H +  E  L+KDR +DQ+++  ++A+ +V +  +L F  I+  Y+  P + +E ++ VLI
Sbjct:   29 FVTLCKELFVTNTVCNRAWAIWTSAAISAEKINNSNRPLWGVCVFISAV---------DLEEISFTFTQLLKAVGLRLKQFCDLVRKLDENVDTISSEVNSTVMKLEKKYDVSLALYQRF----------------GKR-----------QELLRSSWIMFLLAKGSALQMEDDLVISFQILLCVLEFCTKRCPSTLLQPLYKSAVSATAQSPPTRTSRRNKAKPRPPEMDVQLLETLCKESDCSMDEVKNVYQSSFCAFLDSL----SLSGSQ------------EFPAVETLSKKYDELYHKNKDFDARLFLDDD--ETLCPVKEEATKV----EMMPKKNQSGEENV---LVPPQTPIR-------------AAMNSIQQLRGGLT---SASDQPSGNLIVYF-----------------KNCTVDPSEEITKRVGQLGQIFCQKF-------------------AEAVGQRCEGLGKTRFTL----------GVQLHYKVMESMLKSEEKRLSVQNFSKLLNNATFHTSLLASALEVVLATYVGGSLKNGGSESPETDLCFPWILDVFQLHAFDFYKVIESFIKAEPTLKHDMIEHLGRCEHQIMESIAWKADSPLFELLRQSREEGPGEQAEPPATLNQPLQHNHTA--------ADLYLSPLRPSRQLPAAA---APPAAPPAAAAAEVDPPAMPLSQPPAPGTKQH----------------RSNSLSLFYKKLYRMAYLRLKMLFSHLLNSHTELEPIIWTLLQHTLQNEYELMKDRHLDQLMMSAMYAICKVKNV-DLRFKTIVTAYKELPNTNQETFKRVLI 709          
BLAST of retinoblastoma-like protein vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006674.1 (pep scaffold:Pmarinus_7.0:GL476370:237504:270633:-1 gene:ENSPMAG00000005931.1 transcript:ENSPMAT00000006674.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 336.65 bits (862), Expect = 1.575e-98
Identity = 197/626 (31.47%), Postives = 332/626 (53.04%), Query Frame = 1
Query:  103 RFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNIN--SLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKI-DESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKS-KQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSL--ARSGKAPSIDEVTPPERIE 1959
            +FE+LC DL ++ +   EAW  ++++ TN+ ++GD+L WL CALY   RK+    +   +L+   VSL R+L  SK+S + FF ++ KW +M  +  + R RIER+E  F+VS VIF K    F  +F+   DE+       ++ ++ CT  +LF+F W L+++ K NFP I  D++ S+ LLLC LD +  NAL+S   K L N +F+GLP +F N++++ P   P ++  +C  +D   ++ K  ++ +++ Y+ KL E++++KG+       L   +F  N + I   Y EY++  GDFDER++L  +A EE+G+   +   +M     TP     + E +         + ++   K  +   +T  +G          F    +   +   L ALLS  +   SE L  ML++       E + TR+ ++   F   Y G   D +   +I F +K       R +    +YY  LE ++  E  +++ +                  D++ LL++D FHR+L A C+EIVL   +S + FPW+L+ L +    FYK++E+ +R  + L R+MVK+ + V E +++S +WR DS LWD+L  A +   P+ +EVT P  +E
Sbjct:   28 KFEELCQDLNMDEST-HEAWAGFEKIRTNFTLEGDELHWLACALYVACRKTLIPTVGRGTLEGNCVSLTRILRSSKLSLIAFFGKMKKWGEMAQVGSDFRCRIERLERNFAVSTVIFKKLEPIFLSLFRDPQDEAPRQPRGRKQRRLPCTVSDLFKFCWTLFVRTKANFPMISDDLVNSYHLLLCCLDLMYGNALLSSHRKDLLNPNFQGLPEEFGNKDFRPPAEPPCIIDQLCVLHDGIVLEAKGIKEHYWKPYVRKLFERKILKGKIDTLSGFLDVSSFTDNEKAINREYEEYVLTVGDFDERVFLGEDADEELGT--PQKGTVMPG---TPGVGHELAEKMKI-----KRNLQQHFEKTRSLAPSTPLTGRRYLKEKEQGFTPVSTATQSVGRLQALLSGLRGAPSENLLTMLRSSS-RDQTEAVQTRVREMGATFCKHYTGP-SDGQPGSQIDFAQK-------RLKLAEILYYKVLEGVITQEKKRVQGK------------------DLTTLLEQDVFHRSLMACCLEIVLFSYNSQRTFPWILDTLSISPYSFYKVIEVLIRAEEGLSRDMVKHLNHVEETVLESLAWRRDSPLWDALHAAHAAGTPTCEEVTLPNHLE 615          

HSP 2 Score: 103.605 bits (257), Expect = 1.242e-22
Identity = 82/285 (28.77%), Postives = 134/285 (47.02%), Query Frame = 1
Query: 2218 RHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIES--VKTNTGITTGG---------------------LPTDCKTNVHTSPGGTQRLIRTK----------EVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPK-RVTFTVNSSPSK 2970
            R  SLALFFR +Y L+S+RLRD+C +L +S +L  K+WT FEH +   T+L+ DR +DQ+++C I+ + +V  S   +F +I++ YR QPQ+   +YRSVL++    + N+G + G                      LP    ++   +P    RL+ +           E R D+ +FYN  ++  +  +  ++  N L +   V        S L    + P                      + RR+S+   I+VSP K     SP+ R+ +  N SPS+
Sbjct:  825 RTGSLALFFRKVYHLASVRLRDLCQKLDVSPELRSKVWTCFEHSLVHCTNLMADRHLDQLLMCAIYVMAKVTKSER-SFQDIMKWYRSQPQANSHVYRSVLLKGRRRRRNSGSSEGSTEARDRGERESSPPSMRSSSTLPVPHPSSAPPTP---TRLLGSSCHPDNEDEEEEERGDLIQFYNQTYISCIRTFALKYTGNNLETAKEVPPL-----SPLPLLRTHP---------------------CSPRRVSHMHPIYVSPHKNGAPFSPRSRLLYCFNQSPSR 1079          
BLAST of retinoblastoma-like protein vs. Ensembl Nematostella
Match: EDO46411 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RQ05])

HSP 1 Score: 357.836 bits (917), Expect = 7.968e-106
Identity = 204/641 (31.83%), Postives = 339/641 (52.89%), Query Frame = 1
Query:   76 EDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKS---TTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDE-SHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQ-LFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGN 1980
            ED++    +RF+++C +L ++    E AW  Y+ + TNY ++GD L WL CALY   R+S   T D+  +++   VSL RLL  SK+S +QFF ++ KW DM + + E R +IE +E  F VS VIF+KY   F ++F+   E +   Q   +  K  C+  ++F F W LY++ K NFPAI  D++ S+ LLLC LD + SNAL ++ ++ L N+ F GLPSDF+ R+ + P   P ++  +C       ++ KS ++ +++ +++KL EK V++G E     +L   NFE N + I   Y EY++++GDFDERI+L   A  EIG               TP+ +    EV  C       + ++  +K  +    T  +G               +   + + L A+ S  +   SE L  + +  C   P++ II R++ L  +FL  Y     +     R        + +L+R +    +YY  LE I  SE  +++                  ++D++ LL++D FHR+L A C+EIV+   +S + FPWV+ +L L   +FYK++E  ++  D L R++VK+ + + E +++S +W  DS LW ++ ++G  PS ++VT P  +E +    N
Sbjct:    6 EDEDTITKERFDNVCSELNMDEETAESAWSSYETIRTNYTLEGDSLHWLACALYVACRRSVVPTVDSSGTVEGNCVSLTRLLRASKLSLIQFFSKMKKWLDMSNASSEFRKKIEHLERNFQVSTVIFNKYRPIFLDLFKNPSEDTPKAQRSRKSRKQPCSISDVFSFCWTLYVEAKGNFPAISDDLVNSYHLLLCCLDLMYSNALAARHRRDLINTEFEGLPSDFNTRDVRGPSDAPCIVDVLCTKYQGIVLEAKSIKEHYWKPFVQKLFEKRVLRGHEESLSGILDLGNFEANWKAINKEYEEYVLSAGDFDERIFLGEEAHIEIG---------------TPAKLFGSSEVDECQKSGLKKNLQEHFSKTRSLAPQTPLTGRRYLKEKDPCITPVSTATQSVSRLQAMCSGLKPTPSERLLTIFK-ECSRDPLQSIIDRVENLGEIFLKEYVQPSAE-----RPNSPCSTREFALRRLKLAEILYYKVLENITLSEKRRLQ-----------------GHLDLTTLLEQDVFHRSLLACCLEIVIFSYNSQRTFPWVISILGLAPYYFYKVIESLIKAEDGLSRDVVKHLNHIEEQVLESLAWSGDSPLWMTIEQAGGVPSCEDVTIPNHVEAAHPNQN 608          

HSP 2 Score: 129.798 bits (325), Expect = 2.056e-30
Identity = 87/273 (31.87%), Postives = 139/273 (50.92%), Query Frame = 1
Query: 2227 SLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKT-NVHTSP-------------------GGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSP-KRVTFTVNSSPSKELRD 2982
            SLALFFR +Y ++S+RLRD+C RL ++ +L  K+WT FEH +     + KDR +DQ+++CC++ + +V +S  L+F  I++ YR QPQ+   +YRSV+I++ +      TG   +   + +  TSP                        ++ T+  R D+  FYN VF+ T+ N+  +F                        SSS   L  P LSP+PI  N      S  R++S    +++SP K  + M+P  R+ +  + SP+K LRD
Sbjct:  790 SLALFFRKVYHMASVRLRDLCARLDVNEELRGKMWTCFEHSLMHLPEIAKDRHLDQILMCCVYVMGKVTNS-ELSFQNIMKCYRTQPQAASHVYRSVMIKNRRRAPIPNTGSESSRGDSGSTRTSPIRSTSTIPSTPPPPGGSSSTENSPVLETE--RGDLIEFYNKVFIKTIKNFALKF------------------------SSSDRSLESPPLSPLPIVRNQGH---SPRRQVSARHPVYISPHKNGVPMTPTTRMLYCFSESPAKNLRD 1032          
BLAST of retinoblastoma-like protein vs. Ensembl Medaka
Match: rbl1 (RB transcriptional corepressor like 1 [Source:NCBI gene;Acc:101168176])

HSP 1 Score: 308.531 bits (789), Expect = 8.015e-88
Identity = 190/634 (29.97%), Postives = 321/634 (50.63%), Query Frame = 1
Query:   82 QEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGG-QSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAP-ERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYN-------GKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSG-KAPSIDEV 1938
            +E  + +  E LC +L ++     EA D +  +   Y ++G+ + WL C+LY   RK +T  +    ++   VSL R+L  SK+S +QFF ++ KWADM +++++ R R++R+E  F VS VIF K+   F ++FQ    S    Q    K + L C   ++F+F W L++  K NF  I  D++ S+ LLLC LD +  NAL+ +  K L N +FRGLP  +       P E  P VL+ +CE +D   ++ K  R  +FR YI+KL ++++++G +     +L   NF  N++ +   Y EY++  GDFDER++L  +A EEIG+         +  D +   M+  +E       P S+    A + P  G+       ++             S   + + L ++++  +   SE L  + +T C   P   ++ R+  L   F   Y        G  ID+  +               R +    +YY  LE +L  E  +++ R                  D+SALL++D FH +L A C+E+VL    S + FPW+++V +L   +F+K++E+F+R  + L R+MVK+ + + E +++S +W  DS LW +L  +G + PS++EV
Sbjct:   56 EESSVRRSLEVLCQELNMDEQTASEAMDNFTSIWNTYTLEGEVVHWLACSLYAACRKGSTPTVGKGLMEGNCVSLTRILRCSKLSLIQFFSKMRKWADMSNLSQDFRLRMDRLERNFEVSTVIFRKFEPIFMDMFQNPQGSEPPRQPRSRKHRRLPCHISDVFKFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLVFGNALLCANRKDLINPTFRGLPPQYRADCHVVPDEPPPCVLERLCELHDGLVVEAKGIRQHYFRPYIQKLFQRQILRGNQELLTEMLDPQNFIDNNKAVNREYEEYVLTVGDFDERVFLGADADEEIGTPRK------VLPDRSAGQMQQHRE------KPASL----APSTPLTGRGYLKEKDLL--------VTPVSSATQSVSRLQSMVAGLRTAPSENLMQIFRT-CSRDPTGSVLARVKTLGQTFKEHYTNDSEDTPGSHIDFAEN---------------RLKLAEILYYKVLENVLVQETKRLQGR------------------DMSALLEQDIFHCSLMACCLEVVLFSYSSQRTFPWIIDVFKLAPFYFFKVIEVFIRSEEGLSRDMVKHLNSIEEQVLESRAWTEDSALWSALKAAGNEVPSVEEV 631          

HSP 2 Score: 117.087 bits (292), Expect = 4.197e-26
Identity = 95/300 (31.67%), Postives = 150/300 (50.00%), Query Frame = 1
Query: 2116 DESARAAAQLLSANDDEKQENVEIETSHKLVYSIRH---DSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIE------SVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAK-TQITMSPKRVTFTVNSSPSKELRD 2982
            D S    AQ L  +   +       T+     S R     SLALFFR +Y L+S+RLRD+C +L +S +L  KIWT FEH +   T L+K+R +DQ++LC I+ ++++    +  F +I++ YR QPQ++  +YRSVLI       S   N    +       + +    PG    +   +E R D+ +FYN V++  + ++  R+                        ++S  Q + P LSP P +R    Q L  + RR+S + +++VSP K +    SP   T+ +NSSPSK+L D
Sbjct:  769 DSSGVVTAQFLLTSSPSRPAAAVAMTTEPYTGSGRPRRTGSLALFFRKVYHLASVRLRDLCMKLDVSSELRGKIWTCFEHSLVHCTDLMKNRHLDQLLLCSIYIISKITKETH-TFQDIMKCYRSQPQASSYVYRSVLIRRTPKELSADENMEEGSASEEESARKSSQL-PGDPPPV---EEERGDLIQFYNTVYVVKMKSFALRY------------------------AASDNQADAPPLSPFPSVRA---QPL--SPRRVSQSHSLYVSPHKNSPACFSPNSYTYRINSSPSKDLSD 1034          
BLAST of retinoblastoma-like protein vs. Ensembl Medaka
Match: rbl1 (RB transcriptional corepressor like 1 [Source:NCBI gene;Acc:101168176])

HSP 1 Score: 272.322 bits (695), Expect = 2.139e-75
Identity = 180/638 (28.21%), Postives = 301/638 (47.18%), Query Frame = 1
Query:  196 IDGDQLQWLVCALYECVRKSTTDNINS--LDNTYVSLARLLSVSKM------------------------------------------SFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGG-QSMEEKFKVL-CTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALI-SKSKQLFNSSFRGLPSDFHNRNWKAP-ERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYN-------GKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVD-LPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSG-KAPSIDEV 1938
            + G+ + WL C+LY   RK +T  +    ++   VSL R+L  SK+                                          S +QFF ++ KWADM +++++ R R++R+E  F VS VIF K+   F ++FQ    S    Q    K + L C   ++F+F W L++  K NF  I  D++ S+ LLLC LD +  NAL+ +  K L N +FRGLP  +       P E  P VL+ +CE +D   ++ K  R  +FR YI+KL ++++++G +     +L   NF  N++ +   Y EY++  GDFDER++L  +A EEIG+         +  D +   M+  +E                  KP +   +T  +G        +      S   + + L ++++  +   SE L  + +T C   P   ++ R+  L   F   Y        G  ID+  +               R +    +YY  LE +L  E  +++ R                  D+SALL++D FH +L A C+E+VL    S + FPW+++V +L   +F+K++E+F+R  + L R+MVK+ + + E +++S +W  DS LW +L  +G + PS++EV
Sbjct:   70 LQGEVVHWLACSLYAACRKGSTPTVGKGLMEGNCVSLTRILRCSKLRSGSALQLLLDFTASPGQTGSACATLGFASSCLVPFVVGPPPSLIQFFSKMRKWADMSNLSQDFRLRMDRLERNFEVSTVIFRKFEPIFMDMFQNPQGSEPPRQPRSRKHRRLPCHISDVFKFCWTLFVYTKGNFRMIGDDLVNSYHLLLCCLDLVFGNALLCANRKDLINPTFRGLPPQYRADCHVVPDEPPPCVLERLCELHDGLVVEAKGIRQHYFRPYIQKLFQRQILRGNQELLTEMLDPQNFIDNNKAVNREYEEYVLTVGDFDERVFLGADADEEIGTPRK------VLPDRSAGQMQQHRE------------------KPASLAPSTPLTGRGYLKEKDLLVTPVSSATQSVSRLQSMVAGLRTAPSENLMQIFRT-CSRDPTGSVLARVKTLGQTFKEHYTNDSEDTPGSHIDFAEN---------------RLKLAEILYYKVLENVLVQETKRLQGR------------------DMSALLEQDIFHCSLMACCLEVVLFSYSSQRTFPWIIDVFKLAPFYFFKVIEVFIRSEEGLSRDMVKHLNSIEEQVLESRAWTEDSALWSALKAAGNEVPSVEEV 649          

HSP 2 Score: 117.087 bits (292), Expect = 4.596e-26
Identity = 95/300 (31.67%), Postives = 150/300 (50.00%), Query Frame = 1
Query: 2116 DESARAAAQLLSANDDEKQENVEIETSHKLVYSIRH---DSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIE------SVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMP-IRNNFDQILGSTSRRISNNKNIFVSPAK-TQITMSPKRVTFTVNSSPSKELRD 2982
            D S    AQ L  +   +       T+     S R     SLALFFR +Y L+S+RLRD+C +L +S +L  KIWT FEH +   T L+K+R +DQ++LC I+ ++++    +  F +I++ YR QPQ++  +YRSVLI       S   N    +       + +    PG    +   +E R D+ +FYN V++  + ++  R+                        ++S  Q + P LSP P +R    Q L  + RR+S + +++VSP K +    SP   T+ +NSSPSK+L D
Sbjct:  787 DSSGVVTAQFLLTSSPSRPAAAVAMTTEPYTGSGRPRRTGSLALFFRKVYHLASVRLRDLCMKLDVSSELRGKIWTCFEHSLVHCTDLMKNRHLDQLLLCSIYIISKITKETH-TFQDIMKCYRSQPQASSYVYRSVLIRRTPKELSADENMEEGSASEEESARKSSQL-PGDPPPV---EEERGDLIQFYNTVYVVKMKSFALRY------------------------AASDNQADAPPLSPFPSVRA---QPL--SPRRVSQSHSLYVSPHKNSPACFSPNSYTYRINSSPSKDLSD 1052          
BLAST of retinoblastoma-like protein vs. Ensembl Medaka
Match: rb1 (RB transcriptional corepressor 1 [Source:NCBI gene;Acc:100049519])

HSP 1 Score: 119.398 bits (298), Expect = 7.901e-27
Identity = 194/984 (19.72%), Postives = 376/984 (38.21%), Query Frame = 1
Query:  106 FEDLCVDLCIESTVKEEAWDKYKEVS-TNYCIDGDQLQ-WLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVD-MNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIAS-----------NALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVI----NCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKH------------------FPWVLEVLELQAVHFYKIVEIFMRC-VDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISR-DLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVT 2943
            F  LC  L    +V E AW  +K V      +D +Q + W  C        + TD    +D    +L  +L    ++  QF   + K    +D ++ ++   + R+E ++ V   ++ ++     +IF    +     +M              R  W +++  K     +  D+++SFQLLLCTL+                +++SK++     + R   S   +R  ++ E    +L+ +C+ N+ N  + K+   + F  +++ +              ++    +F   +  +   Y E+ + SGD D R++ +              +E +L+  +  S +    +      +   +P     R A       + +  +SG     N  + F N                                 C   P + I  RL+ L  +F    + KF +      I++ +       +R     ++YY  +E +L+SE                  E +L+  + S LL    FH +L A  +E+V+   + S                    FPW+L+V +L A  FYK++E F++    L ++++K+       +++  +WR+ S L++ L R  +A + ++  PP       +  +            +  S +  G R+    P +    +SQ S +     + +A  Q                         + +SL+LF++ +Y L+  RL+ +C  L  +  DL   IWT F+H +  E  L++DR +DQ+++  ++A+ +V S  +L F  I+  Y+  P +++E ++ VLI                                  T+   D I  FYN VF+      +K  ++ Y                    +S++P    P LSP+P          ++  R+  + N+++SP K    +SP  +T
Sbjct:   45 FVTLCKSLHATDSVCERAWTLWKTVQDVMEDVDANQKRLWGSCLFV-----TATD----MDAACFTLTEVLKAVNINVKQFVGLVRKLDVNLDTISTKVNSALMRVEKKYDVMLALYQRFEKTCKKIFASTPDKKERATM--------------RTCWTMFLLAKGRALQMEDDLVISFQLLLCTLELFIKRSSPELLLPLYKSVVSKAQSPLTRTSRRNQSKAKSRVVES-EVNVELLETLCKDNECNAEEVKNVYQTSFSAFLDLM--------------DLSRFPDFPLVT-DVSEQYQEHYLKSGDIDGRLFFD-------------GDETVLAPKVDISQVERTPKKTSPDDDGPLIPPQTPIRAAMNSIKMLRGDLPSSGDQPSSNLAIYFKN---------------------------------CTVDPTQGIQKRLEMLGQVF----SQKFGEAVGPHCIVYGR-------ERFTLGVRLYYKVMEAMLESE------------------EKRLSVQNFSKLLNDSTFHMSLLACALEVVMATYEESSFKNRGCSHGEGDQAVRDLCFPWILDVFDLSAFDFYKVIESFIKAEPTLSKDIIKHLETCENLIMEKIAWRTGSPLFELLKRENEAGATEQAEPPASFSLPLQHNHTAA--------DLYLSPIRPGLRV--LPPESPATPSSQASSQPTPQAAGQAPRQ------------------------PKSNSLSLFYKKLYRLAYTRLKTLCSCLLSNHPDLEHVIWTLFQHTLQYEYDLMRDRHLDQLMMSAMYAICKVKSV-DLRFKLIVSAYKNMPNTSQETFKHVLI----------------------------------TEGQYDSIIVFYNQVFM----QKLKTNILQY--------------------ASTRP----PTLSPIPQIPCSPYKFPNSPLRVPGSNNVYISPLKNS-RLSPGMMT 816          
BLAST of retinoblastoma-like protein vs. Ensembl Medaka
Match: rb1 (RB transcriptional corepressor 1 [Source:NCBI gene;Acc:100049519])

HSP 1 Score: 92.4337 bits (228), Expect = 1.643e-18
Identity = 77/317 (24.29%), Postives = 144/317 (45.43%), Query Frame = 1
Query: 1627 IDISALLKKDEFHRALYAICVEIVLICSDSSKH------------------FPWVLEVLELQAVHFYKIVEIFMRC-VDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISR-DLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSV 2517
            I  S LL    FH +L A  +E+V+   + S                    FPW+L+V +L A  FYK++E F++    L ++++K+       +++  +WR+ S L++ L R  +A + ++  PP       +  +            +  S +  G R+    P +    +SQ S +     + +A  Q                         + +SL+LF++ +Y L+  RL+ +C  L  +  DL   IWT F+H +  E  L++DR +DQ+++  ++A+ +V S  +L F  I+  Y+  P +++E+ R V
Sbjct:  438 IIFSKLLNDSTFHMSLLACALEVVMATYEESSFKNRGCSHGEGDQAVRDLCFPWILDVFDLSAFDFYKVIESFIKAEPTLSKDIIKHLETCENLIMEKIAWRTGSPLFELLKRENEAGATEQAEPPASFSLPLQHNHTA--------ADLYLSPIRPGLRV--LPPESPATPSSQASSQPTPQAAGQAPRQ------------------------PKSNSLSLFYKKLYRLAYTRLKTLCSCLLSNHPDLEHVIWTLFQHTLQYEYDLMRDRHLDQLMMSAMYAICKVKSV-DLRFKLIVSAYKNMPNTSQEVIRPV 719          
BLAST of retinoblastoma-like protein vs. Planmine SMEST
Match: SMESG000055551.1 (SMESG000055551.1)

HSP 1 Score: 2098.55 bits (5436), Expect = 0.000e+0
Identity = 1034/1034 (100.00%), Postives = 1034/1034 (100.00%), Query Frame = 1
Query:   52 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWXXXXXXXXXXXXLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDXXXXXXXXXXKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 3153
            MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ
Sbjct:    1 MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCIDGDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHRISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESHGGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCTLDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESNDMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRGIMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAMRYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNYDSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSLLFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKSEISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVLICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSENLVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVESNRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLSANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLHISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLAFHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSPGGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSLTGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVSPAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKRSEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ 1034          
The following BLAST results are available for this feature:
BLAST of retinoblastoma-like protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
RBL29.241e-9832.19RB transcriptional corepressor like 2 [Source:HGNC... [more]
RBL11.002e-9431.20RB transcriptional corepressor like 1 [Source:HGNC... [more]
RBL11.934e-9431.20RB transcriptional corepressor like 1 [Source:HGNC... [more]
RBL27.744e-8932.11RB transcriptional corepressor like 2 [Source:HGNC... [more]
RB11.422e-3521.13RB transcriptional corepressor 1 [Source:HGNC Symb... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 1
Match NameE-valueIdentityDescription
lin-351.538e-1921.19Retinoblastoma-like protein homolog lin-35 [Sourc... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Rbf8.158e-3125.00gene:FBgn0015799 transcript:FBtr0070146[more]
Rbf27.689e-1720.98gene:FBgn0038390 transcript:FBtr0083213[more]
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BLAST of retinoblastoma-like protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rbl23.959e-10032.10retinoblastoma-like 2 (p130) [Source:ZFIN;Acc:ZDB-... [more]
rbl11.190e-8429.43retinoblastoma-like 1 (p107) [Source:ZFIN;Acc:ZDB-... [more]
rbl26.828e-6227.31retinoblastoma-like 2 (p130) [Source:ZFIN;Acc:ZDB-... [more]
rb14.452e-3121.90retinoblastoma 1 [Source:ZFIN;Acc:ZDB-GENE-040428-... [more]
rbl12.824e-1827.02retinoblastoma-like 1 (p107) [Source:ZFIN;Acc:ZDB-... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rbl11.810e-10527.86retinoblastoma-like 1 [Source:NCBI gene;Acc:100216... [more]
RBL22.527e-8929.17retinoblastoma-like 2 [Source:NCBI gene;Acc:100490... [more]
RBL22.451e-8829.29retinoblastoma-like 2 [Source:NCBI gene;Acc:100490... [more]
RBL22.526e-8428.73retinoblastoma-like 2 [Source:NCBI gene;Acc:100490... [more]
rbl12.588e-8130.22retinoblastoma-like 1 [Source:NCBI gene;Acc:100216... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Rbl21.115e-9831.46RB transcriptional corepressor like 2 [Source:MGI ... [more]
Rbl26.610e-9831.83RB transcriptional corepressor like 2 [Source:MGI ... [more]
Rbl13.802e-9631.52RB transcriptional corepressor like 1 [Source:MGI ... [more]
Rbl24.693e-7828.77RB transcriptional corepressor like 2 [Source:MGI ... [more]
Rb11.309e-3221.01RB transcriptional corepressor 1 [Source:MGI Symbo... [more]
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BLAST of retinoblastoma-like protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|Q08999|RBL2_HUMAN4.438e-9732.19Retinoblastoma-like protein 2 OS=Homo sapiens OX=9... [more]
sp|Q64700|RBL2_MOUSE4.624e-9731.83Retinoblastoma-like protein 2 OS=Mus musculus OX=1... [more]
sp|Q64701|RBL1_MOUSE2.659e-9531.52Retinoblastoma-like protein 1 OS=Mus musculus OX=1... [more]
sp|D3ZS28|RBL1_RAT1.350e-9431.68Retinoblastoma-like protein 1 OS=Rattus norvegicus... [more]
sp|O55081|RBL2_RAT1.766e-9430.94Retinoblastoma-like protein 2 OS=Rattus norvegicus... [more]
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BLAST of retinoblastoma-like protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K9MXG10.000e+099.90Retinoblastoma-like protein OS=Schmidtea mediterra... [more]
D2DJU60.000e+098.26Rb-like protein OS=Schmidtea mediterranea OX=79327... [more]
A0A504YXB40.000e+038.28Putative retinoblastoma protein OS=Fasciola gigant... [more]
A0A4E0S2870.000e+037.58Retinoblastoma protein 1 OS=Fasciola hepatica OX=6... [more]
A0A5K3EXX90.000e+035.48Uncharacterized protein OS=Mesocestoides corti OX=... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
rbl13.536e-10128.22RB transcriptional corepressor like 1 [Source:NCBI... [more]
rbl22.219e-9531.68RB transcriptional corepressor like 2 [Source:NCBI... [more]
rbl22.504e-9531.76RB transcriptional corepressor like 2 [Source:NCBI... [more]
rbl15.807e-8630.00RB transcriptional corepressor like 1 [Source:NCBI... [more]
rb11.178e-3020.67retinoblastoma 1 [Source:ZFIN;Acc:ZDB-GENE-040428-... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000006674.11.575e-9831.47pep scaffold:Pmarinus_7.0:GL476370:237504:270633:-... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of retinoblastoma-like protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO464117.968e-10631.83Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of retinoblastoma-like protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
rbl18.015e-8829.97RB transcriptional corepressor like 1 [Source:NCBI... [more]
rbl12.139e-7528.21RB transcriptional corepressor like 1 [Source:NCBI... [more]
rb17.901e-2719.72RB transcriptional corepressor 1 [Source:NCBI gene... [more]
rb11.643e-1824.29RB transcriptional corepressor 1 [Source:NCBI gene... [more]
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BLAST of retinoblastoma-like protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000055551.10.000e+0100.00SMESG000055551.1[more]
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Cross References
External references for this transcript
DatabaseAccession
SmedGD GBrowseSMED30018689
GenBankAFY07415.1
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018689 ID=SMED30018689|Name=retinoblastoma-like protein|organism=Schmidtea mediterranea sexual|type=transcript|length=3435bp
TGAATTGTTTAAATATATGGCCAAACGCCATATTTAATTTAAATTTTTTA
TATGACTAATTTAAATGATGATTATGAAGATCAAGAAGAGCAGCTTGGTA
AAAGATTTGAAGATTTATGCGTTGATTTGTGTATAGAAAGTACAGTTAAA
GAAGAAGCATGGGATAAATATAAAGAGGTATCAACCAATTATTGTATTGA
TGGTGATCAATTGCAATGGCTTGTTTGTGCACTTTACGAATGTGTTCGTA
AAAGCACAACGGATAACATCAACAGTTTGGACAATACATATGTATCATTG
GCCAGATTACTTTCTGTATCAAAGATGAGCTTTGTGCAATTTTTTCATCG
AATTAGTAAATGGGCAGATATGGTTGACATGAATGAAGAATTAAGGGATC
GAATTGAACGAATCGAAAGTCAGTTTTCAGTTTCTGCTGTTATTTTCGAT
AAATACATTACTGGATTTTATGAAATATTTCAAAAGATTGATGAATCTCA
CGGTGGACAGTCAATGGAGGAGAAATTCAAAGTTCTCTGTACAGATGAAG
AATTATTCCGATTTACTTGGCTGCTGTATATTAAAATCAAAACCAATTTC
CCCGCAATTTGTGGAGATATCATATTATCATTTCAATTGCTTCTATGTAC
ATTGGATTGGATTGCAAGCAATGCATTAATTTCTAAAAGCAAACAACTTT
TCAATTCGAGTTTCAGAGGTTTACCAAGCGACTTTCACAACAGAAATTGG
AAAGCTCCCGAAAGGTTTCCTACAGTTTTAAAATTTATCTGCGAAAGTAA
TGACATGAATTACATCGATTGTAAATCAACTAGGGATAGTTTCTTTCGAA
ATTACATTGAAAAACTACTGGAAAAAGAAGTAATTAAAGGCCGAGAAACA
AAAGAAGACAACGTATTAAGTAGTGTTAATTTTGAATTCAATTCCCGTGG
AATAATGAATCTCTACGGGGAGTATATGATGGCATCGGGTGATTTCGACG
AAAGAATATATCTAAACCCAAATGCGCTCGAGGAAATCGGCTCTGTGAAC
AGCCGTGCCAATGAAATGATGCTAAGTAGCGATTTAACGCCATCAGCAAT
GAGATATATGCAAGAAGTGATCAATTGTGGTGCGGTACCTGGAAGTGTTG
ACACACGCAAGGCAACAGCTAAACCATGCGCCGGCAAACACAATACCGTT
GCCAGCGGTGTCGTCAGTCGGTTAAATGGCGGAGTCAATTTCAACAATTA
CGACTCGAGAGTGATCAACTCGAATTATCTCATTGCATTGCTATCCAAAC
GACAAGCCTACGCCAGCGAAGAACTAACAGATATGCTACAAACTCATTGC
TTCCACAGTCCAATGGAAGATATAATAACTCGATTGGATAAATTAAGCCT
ATTATTTCTTAGTGCATACAATGGGAAATTTATCGACTACAAAACCGATT
TGCGAATATTGTTTCAGAAAAAACAAACAGATCCATCATTACAACGCTGT
CAAACGACTCACAAAATTTATTACTACGCGTTGGAAATGATCTTGAAATC
GGAAATCAGTAAAATTGAACTCCGCTATAAGATGAGATCTAGAAATTCAG
AAGCCGGTGAAATTAAACTCAATAATATCGATATCAGCGCTTTATTGAAG
AAAGATGAGTTTCATCGGGCACTATATGCTATCTGCGTGGAAATCGTTTT
GATATGTTCAGATTCCAGTAAGCATTTTCCATGGGTGCTTGAGGTTCTCG
AATTGCAGGCTGTACATTTTTATAAGATAGTCGAAATTTTCATGAGATGT
GTTGATTTACCCCGAGAAATGGTTAAATACTTTAGTCAGGTTTCAGAAAA
TTTAGTCGACAGTTATTCCTGGCGATCTGATTCGACTCTGTGGGACAGTT
TGGCCAGGAGTGGTAAAGCACCTTCGATCGATGAAGTAACTCCTCCGGAA
CGAATCGAACAATCGTTTAAACAAGGGAATAAAAAGCTTATAGTGGAATC
GAATAGGGAAAGAACTGTTACAAAGTCCTCCATGATAACCGGTAGGCGCC
TAGGGACATCAGCACCTCTCAATCAGAACATACAGAATAGTCAAGGTTCA
TTTCGACATGAAGATGATGAATCCGCAAGGGCGGCCGCTCAATTGCTGTC
AGCTAATGACGATGAGAAGCAAGAAAATGTAGAGATTGAGACTTCTCACA
AATTGGTTTATTCCATCCGGCACGATTCATTGGCCTTGTTTTTTCGACAT
ATGTATTTCCTGAGCAGTTTGCGACTGAGAGATATCTGCGATCGATTGCA
CATCAGCCGAGATTTGATGTGCAAGATATGGACCACATTCGAGCACATAA
TTACTGAAGAAACTCATCTTCTCAAGGACCGATGTATCGATCAGGTGATA
TTGTGCTGCATCTTTGCCGTCACGCGAGTGGCTTCCAGTCGGAACCTGGC
ATTCCACGAGATCCTCCAAATGTATCGGATGCAGCCGCAATCGACTCGAG
AAATTTATCGATCAGTGCTGATCGAGTCCGTGAAAACGAATACCGGCATC
ACAACCGGTGGACTGCCCACCGATTGCAAAACCAATGTCCACACGTCCCC
CGGAGGAACACAGCGACTGATACGAACGAAAGAAGTCCGGGACGACATAA
CCAGGTTTTACAATCACGTGTTCCTGCCAACGGTGCACAACTACGTGAAA
CGGTTCCTTATCAACTACCTGATGAGCGGATCAAACGTATCGGTCAGTTT
GACCGGTCCCAACTCCAACCTATCAAAATCCAGCAGCCAACCGCAACTAA
ACCAGCCACATTTATCCCCAATGCCGATCAGGAACAATTTCGATCAGATC
CTCGGTTCCACTTCACGGAGGATTTCCAACAATAAGAACATATTTGTCAG
TCCCGCTAAGACCCAAATCACAATGTCCCCGAAACGGGTCACGTTCACGG
TGAACAGCAGCCCCAGTAAGGAATTACGGGACATCAATGCAATCATTGCC
AATGCAGCTAATAAAGTTAAAACAGGCCTCTCATTTAACAGCACTAAGCG
ATCGGAACCGACTTTCTTCAGCTCCCAGTCCAATATTTCAGTGCTCGATC
GATCAGGCGGTGGTGGAGGTATCCAGGCCGCTAAGCGATTGCGATTCGAC
CAATAGAATAAATGATGATGATTTCTGTCGGTTTTATCCATATTTATATC
CGTGTAAAATATATTTATGTAGATTGTTATTGCGTGCATGAGAAATGGTT
CATTGTTATTGTTAATTTTTATTTAGTAATGTTTTGTGACATGTTTCTGC
CACGTTTTGGGCTTTTGCTTTATATTTGTAAACTAATTTTGTCAACCCTA
CAGAAAGTAATACAAGAAAGAAAAACAGTAAATTTCATATCTAGAAATAT
AAACAAAAAATTTACTTTATAAAAATAAATTCTCA
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protein sequence of SMED30018689-orf-1

>SMED30018689-orf-1 ID=SMED30018689-orf-1|Name=SMED30018689-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1035bp
MTNLNDDYEDQEEQLGKRFEDLCVDLCIESTVKEEAWDKYKEVSTNYCID
GDQLQWLVCALYECVRKSTTDNINSLDNTYVSLARLLSVSKMSFVQFFHR
ISKWADMVDMNEELRDRIERIESQFSVSAVIFDKYITGFYEIFQKIDESH
GGQSMEEKFKVLCTDEELFRFTWLLYIKIKTNFPAICGDIILSFQLLLCT
LDWIASNALISKSKQLFNSSFRGLPSDFHNRNWKAPERFPTVLKFICESN
DMNYIDCKSTRDSFFRNYIEKLLEKEVIKGRETKEDNVLSSVNFEFNSRG
IMNLYGEYMMASGDFDERIYLNPNALEEIGSVNSRANEMMLSSDLTPSAM
RYMQEVINCGAVPGSVDTRKATAKPCAGKHNTVASGVVSRLNGGVNFNNY
DSRVINSNYLIALLSKRQAYASEELTDMLQTHCFHSPMEDIITRLDKLSL
LFLSAYNGKFIDYKTDLRILFQKKQTDPSLQRCQTTHKIYYYALEMILKS
EISKIELRYKMRSRNSEAGEIKLNNIDISALLKKDEFHRALYAICVEIVL
ICSDSSKHFPWVLEVLELQAVHFYKIVEIFMRCVDLPREMVKYFSQVSEN
LVDSYSWRSDSTLWDSLARSGKAPSIDEVTPPERIEQSFKQGNKKLIVES
NRERTVTKSSMITGRRLGTSAPLNQNIQNSQGSFRHEDDESARAAAQLLS
ANDDEKQENVEIETSHKLVYSIRHDSLALFFRHMYFLSSLRLRDICDRLH
ISRDLMCKIWTTFEHIITEETHLLKDRCIDQVILCCIFAVTRVASSRNLA
FHEILQMYRMQPQSTREIYRSVLIESVKTNTGITTGGLPTDCKTNVHTSP
GGTQRLIRTKEVRDDITRFYNHVFLPTVHNYVKRFLINYLMSGSNVSVSL
TGPNSNLSKSSSQPQLNQPHLSPMPIRNNFDQILGSTSRRISNNKNIFVS
PAKTQITMSPKRVTFTVNSSPSKELRDINAIIANAANKVKTGLSFNSTKR
SEPTFFSSQSNISVLDRSGGGGGIQAAKRLRFDQ*
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protein sequence of SMED30018689-orf-2

>SMED30018689-orf-2 ID=SMED30018689-orf-2|Name=SMED30018689-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=132bp
MHAITIYINIFYTDINMDKTDRNHHHLFYWSNRNRLAAWIPPPPPDRSST
EILDWELKKVGSDRLVLLNERPVLTLLAALAMIALMSRNSLLGLLFTVNV
TRFGDIVIWVLAGLTNMFLLLEILREVEPRI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR028309RB_fam
IPR036915Cyclin-like_sf
IPR002720RB_A
IPR024599RB_N
IPR013763Cyclin-like
IPR002719RB_B
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
Vocabulary: biological process
TermDefinition
GO:0051726regulation of cell cycle
GO:0006357regulation of transcription from RNA polymerase II promoter
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002720Retinoblastoma-associated protein, A-boxSMARTSM01368RB_A_2coord: 402..617
e-value: 2.7E-31
score: 120.0
IPR002720Retinoblastoma-associated protein, A-boxPFAMPF01858RB_Acoord: 402..617
e-value: 4.4E-43
score: 147.4
IPR024599Retinoblastoma-associated protein, N-terminalSMARTSM01367DUF3452_2coord: 68..207
e-value: 2.3E-33
score: 126.9
IPR024599Retinoblastoma-associated protein, N-terminalPFAMPF11934DUF3452coord: 78..207
e-value: 3.8E-32
score: 110.7
NoneNo IPR availableGENE3DG3DSA:1.10.472.10coord: 401..646
e-value: 1.1E-41
score: 145.1
NoneNo IPR availableGENE3DG3DSA:1.10.472.140coord: 13..327
e-value: 3.0E-31
score: 110.5
IPR002719Retinoblastoma-associated protein, B-boxPFAMPF01857RB_Bcoord: 726..878
e-value: 2.1E-41
score: 141.1
IPR028309Retinoblastoma protein familyPANTHERPTHR13742RETINOBLASTOMA-ASSOCIATED PROTEIN RB -RELATEDcoord: 9..996
IPR036915Cyclin-like superfamilySUPERFAMILYSSF47954Cyclin-likecoord: 726..884
IPR036915Cyclin-like superfamilySUPERFAMILYSSF47954Cyclin-likecoord: 415..619