Regulator of telomere elongation helicase 1 homolog
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30018649 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 12
Homology
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Match: BRIP1 (BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol;Acc:HGNC:20473]) HSP 1 Score: 411.764 bits (1057), Expect = 1.582e-129 Identity = 238/679 (35.05%), Postives = 373/679 (54.93%), Query Frame = 1
Query: 244 CSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPET------TWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNGEI-TDSTSEIP---SSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCK-KRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
CST KQ SQ N+ + +K KI+FGTRTHKQI Q+ REL+++AYS M+ILS R+ +C++ EV+ + ++ C +L C ++KI +Q +T WDIE + KK+K CPY+ + ++ ADI+FCPYNY+L+ IR+SM +NL+ ++ILDEAHNIED RE AS S++ + + + L ++ + ++ L + + +E + L +D + K W + L + + H A L+ E +++ + E+P +S ++ M++ + + +D+ I I + + I+ +G + K K+++ VLN WC+NP + F I+ ++I+LTSGTLSP+ SF EL F+ +A H+++ + ++ +IG+GP G + A F T FQDE+G +LL + V GIL FL S+ L+E +RW +TGL + + K++ +EP+ + + +E + Y +K KDGALL+AV RGK SEG+DF+D+ AR VIT+GIP+P++ D +V LK YN + K LL G +WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W++++ E SL F H +V
Sbjct: 219 CST----KQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRG--LLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKV 891 HSP 2 Score: 70.0922 bits (170), Expect = 1.296e-11 Identity = 28/57 (49.12%), Postives = 39/57 (68.42%), Query Frame = 1
Query: 91 EFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
E+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 7 EYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Match: BRIP1 (BRCA1 interacting protein C-terminal helicase 1 [Source:HGNC Symbol;Acc:HGNC:20473]) HSP 1 Score: 409.838 bits (1052), Expect = 1.127e-126 Identity = 238/679 (35.05%), Postives = 373/679 (54.93%), Query Frame = 1
Query: 244 CSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPET------TWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNGEI-TDSTSEIP---SSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCK-KRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
CST KQ SQ N+ + +K KI+FGTRTHKQI Q+ REL+++AYS M+ILS R+ +C++ EV+ + ++ C +L C ++KI +Q +T WDIE + KK+K CPY+ + ++ ADI+FCPYNY+L+ IR+SM +NL+ ++ILDEAHNIED RE AS S++ + + + L ++ + ++ L + + +E + L +D + K W + L + + H A L+ E +++ + E+P +S ++ M++ + + +D+ I I + + I+ +G + K K+++ VLN WC+NP + F I+ ++I+LTSGTLSP+ SF EL F+ +A H+++ + ++ +IG+GP G + A F T FQDE+G +LL + V GIL FL S+ L+E +RW +TGL + + K++ +EP+ + + +E + Y +K KDGALL+AV RGK SEG+DF+D+ AR VIT+GIP+P++ D +V LK YN + K LL G +WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W++++ E SL F H +V
Sbjct: 219 CST----KQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRG--LLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKV 891 HSP 2 Score: 69.707 bits (169), Expect = 1.690e-11 Identity = 28/57 (49.12%), Postives = 39/57 (68.42%), Query Frame = 1
Query: 91 EFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
E+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 7 EYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Match: RTEL1 (regulator of telomere elongation helicase 1 [Source:HGNC Symbol;Acc:HGNC:15888]) HSP 1 Score: 310.457 bits (794), Expect = 1.185e-91 Identity = 219/728 (30.08%), Postives = 341/728 (46.84%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW-------------LKQYQSQLL----LNSRNDECKENAKQV-------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEG-----------EKYAEPINEKVA-------SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKH--FDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M + L+ V V FP +PY Q M +++ + + N ++E PTG+GKT+ LLC+TL W ++ Q +L L+S + + KI + +RTH Q+ QVI EL+ ++Y ++ +L R C++ EV +E + LC+K C + K Q DIE + K ++CPY+ ++ + ADI+F PYNY+L+ R++ ++L+ ++I DEAHN+E +C E AS ++ D+ ++ +L++ K Q + + S L + ED+ K L + +L D + +++ +L E ++ G I DS +I F L +D Q FS+ +EG + Y I+ S W + RK VL+ WC +PG + + RS+ILTSGTL+PV SF E+ F + H++ + ++ + GP G + + F LG+ L + VVP G+LIF S+ ++E ++ W L ++ K +F+EPR +E I AY+ V GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + K Q LSG EWY QA RA+NQA+GR IRHR+D+GA+ + D R
Sbjct: 1 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSY-RPKVCVLGSREQLCIHPEV-KKQESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFSA-----DSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII-QIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARK-----RGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Match: RTEL1 (regulator of telomere elongation helicase 1 [Source:HGNC Symbol;Acc:HGNC:15888]) HSP 1 Score: 309.686 bits (792), Expect = 3.797e-90 Identity = 219/728 (30.08%), Postives = 341/728 (46.84%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW-------------LKQYQSQLL----LNSRNDECKENAKQV-------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEG-----------EKYAEPINEKVA-------SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKH--FDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M + L+ V V FP +PY Q M +++ + + N ++E PTG+GKT+ LLC+TL W ++ Q +L L+S + + KI + +RTH Q+ QVI EL+ ++Y ++ +L R C++ EV +E + LC+K C + K Q DIE + K ++CPY+ ++ + ADI+F PYNY+L+ R++ ++L+ ++I DEAHN+E +C E AS ++ D+ ++ +L++ K Q + + S L + ED+ K L + +L D + +++ +L E ++ G I DS +I F L +D Q FS+ +EG + Y I+ S W + RK VL+ WC +PG + + RS+ILTSGTL+PV SF E+ F + H++ + ++ + GP G + + F LG+ L + VVP G+LIF S+ ++E ++ W L ++ K +F+EPR +E I AY+ V GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + K Q LSG EWY QA RA+NQA+GR IRHR+D+GA+ + D R
Sbjct: 1 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSY-RPKVCVLGSREQLCIHPEV-KKQESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS-----ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII-QIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARK-----RGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Match: RTEL1 (regulator of telomere elongation helicase 1 [Source:HGNC Symbol;Acc:HGNC:15888]) HSP 1 Score: 309.301 bits (791), Expect = 8.418e-90 Identity = 218/728 (29.95%), Postives = 342/728 (46.98%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW-------------LKQYQSQLL----LNSRNDECKENAKQV-------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEK----------------YAEPINEKVA--SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKH--FDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M + L+ V V FP +PY Q M +++ + + N ++E PTG+GKT+ LLC+TL W ++ Q +L L+S + + KI + +RTH Q+ QVI EL+ ++Y ++ +L R C++ EV +E + LC+K C + K Q DIE + K ++CPY+ ++ + ADI+F PYNY+L+ R++ ++L+ ++I DEAHN+E +C E AS ++ D+ ++ +L++ K Q + + S L + ED+ K L + +L D + +++ +L E ++ G I DS +I F L +D Q FS+ +EG + + + + A S W + RK VL+ WC +PG + + RS+ILTSGTL+PV SF E+ F + H++ + ++ + GP G + + F LG+ L + VVP G+LIF S+ ++E ++ W L ++ K +F+EPR +E I AY+ V GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + K Q LSG EWY QA RA+NQA+GR IRHR+D+GA+ + D R
Sbjct: 1 MPKIVLNGVTVDFPFQPYKCQQEYMTKVLECLQQKVNGILESPTGTGKTLCLLCTTLAWREHLRDGISARKIAERAQGELFPDRALSSWGNAAAAAGDPIACYTDIPKIIYASRTHSQLTQVINELRNTSY-RPKVCVLGSREQLCIHPEV-KKQESNHLQIHLCRKKVASRSCHFYNNVEEKSLEQELASPILDIEDLVKSGSKHRVCPYYLSRNLKQQADIIFMPYNYLLDAKSRRAHNIDLKGTVVIFDEAHNVEKMCEESASFDLTPHDLASGLDVIDQVLEEQTKAAQQGEPHPEFS-----ADSPSPGLNMELEDIAKLKMILLRLEGAIDAVELPGDDSGVTKPGSYIFELFAEAQITFQTKGCILDSLDQIIQHLAGRAGVFTNTAGLQKLADII-QIVFSVDPSEGSPGSPAGLGALQSYKVHIHPDAGHRRTAQRSDAWSTTAARK-----RGKVLSYWCFSPGHSMHELVRQGVRSLILTSGTLAPVSSFALEMQIPFPVCLENPHIIDKHQIWVGVVPRGPDGAQLSSAFDRRFSEECLSSLGKALGNIARVVPYGLLIFFPSYPVMEKSLEFWRARDLARKMEALKPLFVEPRSKGSFSETISAYYARVAAPGSTGATFLAVCRGKASEGLDFSDTNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMKGQGGAGGQFLSGQEWYRQQASRAVNQAIGRVIRHRQDYGAVFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Match: rtel-1 (Regulator of telomere elongation helicase 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q93575]) HSP 1 Score: 284.648 bits (727), Expect = 1.076e-82 Identity = 210/731 (28.73%), Postives = 352/731 (48.15%), Query Frame = 1
Query: 115 VTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLN------------SRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQN---CKDLCKKMGCIY--KIDNQPHPETT--------WDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKD----IDYLKMLLPHILKK----------------SGKEDC---------QHDLLTMLEKM----HEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGE-KYAEPINEKVASGEWISCKKR-KADALNNNFVLNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRW--------TNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNP 2088
V FP EPY Q M+ +++ +++ + +E PTG+GKT++LLCSTL W+++ + L+ + DE ++A IF+ +RTH Q+ QV+ EL ++ Y + +IL R C+NQ+V KE ++ C+ L K C Y K D + T DIE + +CPYF + ++A+++ PYNYI++P +R+ ++L+N+I+I DEAHN+E IC AS ++ I+ LK +L ++ + S K D DL+T+LEK+ E+ +L S + K D E ++ L D ++ E + LR+ I + E+ + + D + ++ T D + + E K + ++ K + +CK + D N + +C I + + R+++L SGTLSP+ +F + F AI + H ++ + + G G + F L + + + LL+ EV+P GILIF SS++ ++ + W +N ++ K K + +EPR E+ Y + V + GA LLAV RGK SEG+DF D +R VI +GIPYP I D +VVLK Y + +K + S +WY ++AFRA+NQA+GR +RH++D+G ++++D+R + P
Sbjct: 19 VKFPFEPYECQRIFMKNVVDVLDRKLDAALESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHELNRTEYKWVKTTILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRACHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICESNASAELTSTSIALCIEELKKVLALLVDEEETARSEADAETGAFGSAKIDLTKKLIENLRTEDLMTVLEKIFSLEEEMDKLFGSSQLKSVPPLSGKASDGEILLETLAKAGFDANSV---ERLVDVLRDAISY---LLSKNEEV--ALTEKGDGMEKVADFLLSIYSTHAQDVAAAVGEETVKLVDRVDPKTVAR---NCKLYIQKDKDNEKLTIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGKRG-GLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASAKP 737
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Match: rtel-1 (Regulator of telomere elongation helicase 1 homolog [Source:UniProtKB/Swiss-Prot;Acc:Q93575]) HSP 1 Score: 284.648 bits (727), Expect = 1.076e-82 Identity = 210/731 (28.73%), Postives = 352/731 (48.15%), Query Frame = 1
Query: 115 VTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLN------------SRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQN---CKDLCKKMGCIY--KIDNQPHPETT--------WDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKD----IDYLKMLLPHILKK----------------SGKEDC---------QHDLLTMLEKM----HEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGE-KYAEPINEKVASGEWISCKKR-KADALNNNFVLNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRW--------TNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNP 2088
V FP EPY Q M+ +++ +++ + +E PTG+GKT++LLCSTL W+++ + L+ + DE ++A IF+ +RTH Q+ QV+ EL ++ Y + +IL R C+NQ+V KE ++ C+ L K C Y K D + T DIE + +CPYF + ++A+++ PYNYI++P +R+ ++L+N+I+I DEAHN+E IC AS ++ I+ LK +L ++ + S K D DL+T+LEK+ E+ +L S + K D E ++ L D ++ E + LR+ I + E+ + + D + ++ T D + + E K + ++ K + +CK + D N + +C I + + R+++L SGTLSP+ +F + F AI + H ++ + + G G + F L + + + LL+ EV+P GILIF SS++ ++ + W +N ++ K K + +EPR E+ Y + V + GA LLAV RGK SEG+DF D +R VI +GIPYP I D +VVLK Y + +K + S +WY ++AFRA+NQA+GR +RH++D+G ++++D+R + P
Sbjct: 19 VKFPFEPYECQRIFMKNVVDVLDRKLDAALESPTGTGKTLSLLCSTLAWVQRQKETKPLDFATWQTSGAGGAEKTDEKLKSAYVPTIFYASRTHSQLEQVVHELNRTEYKWVKTTILGSREHFCINQKVKKIKESNRQAHVCRGLVSKRACHYYNKFDACTTDKMTEFLDKGEAMDIEDFVKLGTQNSLCPYFMSRQRSETAELILLPYNYIIDPKMRRRYKLDLKNSIVIFDEAHNLESICESNASAELTSTSIALCIEELKKVLALLVDEEETARSEADAETGAFGSAKIDLTKKLIENLRTEDLMTVLEKIFSLEEEMDKLFGSSQLKSVPPLSGKASDGEILLETLAKAGFDANSV---ERLVDVLRDAISY---LLSKNEEV--ALTEKGDGMEKVADFLLSIYSTHAQDVAAAVGEETVKLVDRVDPKTVAR---NCKLYIQKDKDNEKLTIKYFCFQASISMRMLKMRGVRNVLLASGTLSPIQAFTYNMGLNFGAILENEHALKQVPVLTSIVTRGKRG-GLAGSFQNRKNLDYVTGVAEALLRVMEVIPQGILIFFSSYSQMDELVATWKTTKWSSNSNESFWEKMEKTKRVVVEPRAKEELAAIRLRYTQGVSEQHGAALLAVCRGKVSEGIDFCDAESRAVIIIGIPYPPIHDERVVLKKMYLDDLMGRKDTKSERQSSQDWYQMEAFRAVNQAIGRVLRHKDDFGTVVLMDTRYASAKP 737
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Match: dog-1 (Deletions Of G-rich DNA [Source:UniProtKB/TrEMBL;Acc:O62217]) HSP 1 Score: 217.624 bits (553), Expect = 3.366e-59 Identity = 117/319 (36.68%), Postives = 179/319 (56.11%), Query Frame = 1
Query: 1303 VLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTS--KLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD---------GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGG-----LCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDK 2211
+++WCM+P + F + +RSI+L SGTL P+ + + EL +F + V+ + F A + GP GN ++ + TS + SF ELG ++ VP GIL FL S+ +++ Q + +I K + EPR++SE+ +D + + D G+L+ AVFRGK SEG+DFAD+ AR+VI+VGIPYP+ D +V K YN K + +L+G+EWY QA+RALNQALGRC+RH+ DWGAM+MID RL+ GG + WI+ + + + ++ + + FI V+ K
Sbjct: 661 TISLWCMSPALSFFDAFNETRSIVLASGTLCPMDTLKTELGMEFKQQVEGDQVINKDNIFAAVLPIGPFGNRIQCTYRNTSDPESSFYCELGAIIKYVCSNVPAGILCFLPSYRVLDQLKQCMIRNSTMRQIEMKKVVLYEPRRSSELTSVMDQFDAAIFDPSRFGANINGSLMFAVFRGKVSEGIDFADDRARVVISVGIPYPNAMDDQVNAKKLYNDQNSK--EKGILTGDEWYTTQAYRALNQALGRCLRHKNDWGAMLMIDERLERQTGNLVGGASSARVSKWIRAQLKSYPSFKEFNANFREFIQRRHAVEKAK 977 HSP 2 Score: 133.265 bits (334), Expect = 1.009e-31 Identity = 68/180 (37.78%), Postives = 107/180 (59.44%), Query Frame = 1
Query: 328 QVKIFFGTRTHKQIGQVIRELKKSAYSNT-RMSILSGRNLSCLNQEVLMSKEIDQNCKDL--CKKMGCIYKIDNQPHPE--------------TTWDIESI--SMKLKKVKICPYFQFKSWM-KSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDID 807
+V+I++GTRTHKQI QV++E + Y+ + +IL+ R SC+N +I Q CK++ +GC +K +P E +D+E I ++ + ++CPYF + + ADI+FCP++Y+++P IR S V + N+I+ILDEAHNIED CRE AS S + K++D
Sbjct: 237 RVRIYYGTRTHKQIAQVVKEFSRLPYAKILKHTILASREQSCINPAARKHADISQYCKEVNSAHSIGCSFKSAMKPRFEKALPLRDHLERNGTVVFDMEKIVETLAISYPQLCPYFSTNRILTQDADIIFCPFSYLVDPLIRNSSDVQIRNSIVILDEAHNIEDTCREAASFSFTEKELD 416 HSP 3 Score: 58.5362 bits (140), Expect = 1.827e-8 Identity = 30/57 (52.63%), Postives = 37/57 (64.91%), Query Frame = 1
Query: 109 VPVTFP--IEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQY 273
VPV P + Y Q M+ RI+ ++ S+N L E PTGSGKT+ALL ST WLKQY
Sbjct: 80 VPVRVPRGLSLYSTQKLMIVRILTALKNSQNVLGESPTGSGKTMALLASTCAWLKQY 136
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Match: chl-1 (ATP-dependent DNA helicase chl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21489]) HSP 1 Score: 154.066 bits (388), Expect = 1.856e-38 Identity = 165/675 (24.44%), Postives = 282/675 (41.78%), Query Frame = 1
Query: 301 NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVL---MSKEIDQNCKDLCKKMGCIYKIDNQPHPET----------------TWDIESI-----SMKLKKV----------KICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLF-----YKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQL----------IDSFIMLVKLMMDSDKTKQNDFSIVITEG---------EKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELN-----CKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVK--DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLS-GNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
++E ++ K +KIF+ +RTH Q+ Q+ EL K+ + R+ + R C+N+EV ++ I++ C +L +K G K Q + + IE + S KLK CPYF + + +V PY +L+ RK+ G+ L++N+I+LDEAHN+ + S IS K + L+ + H+LL M + +E L+SK+ EDV+ + QL +N + E +L KL + E TD + +M+L + KLM + + + + + + + + K G I +K +A +LN P ++ +R+ IL GT+ P + L+ F HV+ + ++ G + + T + L + +PNG++IF+ S+ + F ++ G++ I + K++F E RQ + ++ D + + K GA+L AV GK SEG++F DE R VI +G+PYP+ ++ +M K D Q+ + GN Y A+NQA+GR IRHR D+ A+ + D R + + L WI R
Sbjct: 174 DEEEEKPLKCLKIFYASRTHSQLEQLAEELAKTRF-QPRIVTCASRGTLCVNEEVKKLKLNHLINEKCMEL-RKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIELKDNVIVLDEAHNVLNTISSLYSAEISTKSLTLALRLIREYNAHYKLKLLAHNLLYMKQ-----LESLTSKMLIFLNSQSKEDVM-------TMAQLARNLNI-------LEINLFKLAEYM----EKTDLCKKFHGFYMRLQKEEIKKENEKPKLTGIQKLMAAKEAEPEPEAEPLPPPKPVPSPLFSLKSFIDALTNKCEDGRII-VEKSATEAKFRFMLLN-----PADRLSEVVTSARATILVGGTMEPAQLLVETLSRGSIGADSIRRFSCCHVIDDSQLLAVTVERTVDGKPFQLTYQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVFTESRQPT--SDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERM-------KFLDTQMPNGGNLLYESLCMHAVNQAIGRAIRHRRDYAAVYLFDDRY--AKESTRRKLSTWIGDR 806 HSP 2 Score: 54.299 bits (129), Expect = 3.372e-7 Identity = 22/50 (44.00%), Postives = 35/50 (70.00%), Query Frame = 1
Query: 118 TFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
+FP +PY QL +MR I I + + + E PTG+GK++++LCST+ WL+
Sbjct: 5 SFPFQPYDIQLNLMREIRQCIEQRKIGIFESPTGTGKSLSVLCSTMTWLE 54
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Match: chl-1 (ATP-dependent DNA helicase chl-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21489]) HSP 1 Score: 154.066 bits (388), Expect = 1.856e-38 Identity = 165/675 (24.44%), Postives = 282/675 (41.78%), Query Frame = 1
Query: 301 NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVL---MSKEIDQNCKDLCKKMGCIYKIDNQPHPET----------------TWDIESI-----SMKLKKV----------KICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLF-----YKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQL----------IDSFIMLVKLMMDSDKTKQNDFSIVITEG---------EKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELN-----CKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVK--DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLS-GNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
++E ++ K +KIF+ +RTH Q+ Q+ EL K+ + R+ + R C+N+EV ++ I++ C +L +K G K Q + + IE + S KLK CPYF + + +V PY +L+ RK+ G+ L++N+I+LDEAHN+ + S IS K + L+ + H+LL M + +E L+SK+ EDV+ + QL +N + E +L KL + E TD + +M+L + KLM + + + + + + + + K G I +K +A +LN P ++ +R+ IL GT+ P + L+ F HV+ + ++ G + + T + L + +PNG++IF+ S+ + F ++ G++ I + K++F E RQ + ++ D + + K GA+L AV GK SEG++F DE R VI +G+PYP+ ++ +M K D Q+ + GN Y A+NQA+GR IRHR D+ A+ + D R + + L WI R
Sbjct: 174 DEEEEKPLKCLKIFYASRTHSQLEQLAEELAKTRF-QPRIVTCASRGTLCVNEEVKKLKLNHLINEKCMEL-RKNGMSEKEKVQKLEKGTTKKTKTCATSCEFYNSTQIEDVVNGVLSNKLKSTLEVSKQGKLSNGCPYFATRKSVPQCQLVLLPYQVLLHDGTRKAWGIELKDNVIVLDEAHNVLNTISSLYSAEISTKSLTLALRLIREYNAHYKLKLLAHNLLYMKQ-----LESLTSKMLIFLNSQSKEDVM-------TMAQLARNLNI-------LEINLFKLAEYM----EKTDLCKKFHGFYMRLQKEEIKKENEKPKLTGIQKLMAAKEAEPEPEAEPLPPPKPVPSPLFSLKSFIDALTNKCEDGRII-VEKSATEAKFRFMLLN-----PADRLSEVVTSARATILVGGTMEPAQLLVETLSRGSIGADSIRRFSCCHVIDDSQLLAVTVERTVDGKPFQLTYQTRGADTTLRSLATSIQALIPHIPNGVVIFVPSYDFLFNFQKKMKEFGILKRIEEKKAVFTESRQPT--SDVWDRFSRAAKTSKGAILFAVVGGKMSEGINFCDELGRAVIVIGLPYPNKTSVELRERM-------KFLDTQMPNGGNLLYESLCMHAVNQAIGRAIRHRRDYAAVYLFDDRY--AKESTRRKLSTWIGDR 806 HSP 2 Score: 54.299 bits (129), Expect = 3.372e-7 Identity = 22/50 (44.00%), Postives = 35/50 (70.00%), Query Frame = 1
Query: 118 TFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
+FP +PY QL +MR I I + + + E PTG+GK++++LCST+ WL+
Sbjct: 5 SFPFQPYDIQLNLMREIRQCIEQRKIGIFESPTGTGKSLSVLCSTMTWLE 54
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Fly
Match: CG4078 (gene:FBgn0029798 transcript:FBtr0070807) HSP 1 Score: 371.703 bits (953), Expect = 7.457e-115 Identity = 240/742 (32.35%), Postives = 382/742 (51.48%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK----QYQSQLLLNSRND-----------ECKENAKQV---------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCK----KMGCIYKI---DNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILK--KSGK-EDCQHDLLT--MLEKMHEVIELLSSKLFYKDEDVLKKTWDLESF-----VQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSI-VITEGEKYAEPINEKV-ASGEWISCKKRKADALNNNFV---LNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY-NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNC 2148
M E ++ +PV FP EPYP Q M ++I+ + N ++E PTG+GKT++LLCS+L W++ ++Q Q++ + D + E AK + K+ + +RTH Q+ Q +RELK++AY+N R +L R+ C++ EV M ++ + N ++CK C +++ + HP+ T DIE + +++KICPYF + + ADI F PYNY+L+P RK+ + L N I+ILDEAHNIE IC E AS+ I D+ + HI++ SG+ +D D L+ + + E+L D V+ D +F +LL N+ + L KL + V + + +F L D ++ D F + V+ E K + G W+ K A A + V +N WC NPG +Q+ + RS+ILTSGTL+P+ EL + + H+V + ++ IG GP + + ++ + LGQ +L + +VP+G+L+F S+ ++ + W +GL +I K IF+EPR + ++ +++ ++D GA+ +AV RGK SEG+DFAD R VI G+P+P + DPKV+LK Y N+ + ++QLLSG EWYN+ A RA+NQA+GR IRHR D+GA+++ DSR ++ L WI+ D C
Sbjct: 1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEV-MREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQ--QMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLG-KGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTR--ENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQ--LSKWIRGHLGDRPQC 734
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Fly
Match: CG4078 (gene:FBgn0029798 transcript:FBtr0332398) HSP 1 Score: 371.703 bits (953), Expect = 7.457e-115 Identity = 240/742 (32.35%), Postives = 382/742 (51.48%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK----QYQSQLLLNSRND-----------ECKENAKQV---------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCK----KMGCIYKI---DNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILK--KSGK-EDCQHDLLT--MLEKMHEVIELLSSKLFYKDEDVLKKTWDLESF-----VQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSI-VITEGEKYAEPINEKV-ASGEWISCKKRKADALNNNFV---LNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY-NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNC 2148
M E ++ +PV FP EPYP Q M ++I+ + N ++E PTG+GKT++LLCS+L W++ ++Q Q++ + D + E AK + K+ + +RTH Q+ Q +RELK++AY+N R +L R+ C++ EV M ++ + N ++CK C +++ + HP+ T DIE + +++KICPYF + + ADI F PYNY+L+P RK+ + L N I+ILDEAHNIE IC E AS+ I D+ + HI++ SG+ +D D L+ + + E+L D V+ D +F +LL N+ + L KL + V + + +F L D ++ D F + V+ E K + G W+ K A A + V +N WC NPG +Q+ + RS+ILTSGTL+P+ EL + + H+V + ++ IG GP + + ++ + LGQ +L + +VP+G+L+F S+ ++ + W +GL +I K IF+EPR + ++ +++ ++D GA+ +AV RGK SEG+DFAD R VI G+P+P + DPKV+LK Y N+ + ++QLLSG EWYN+ A RA+NQA+GR IRHR D+GA+++ DSR ++ L WI+ D C
Sbjct: 1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIHCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQKQMVKMEKADFSGLGGGAPGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEV-MREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGPTIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMAGDEPKDFTLDDLTLLKEMLLELEKAIDAIVVDNAVDGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQ--QMSIRKGGTFTLLSDLLTIVFANKEDVMSKVYASFKVHVLVEESKQGHGKQQGAKQQGGWLG-KGTIAAATGLSKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVARIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISCKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTR--ENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQ--LSKWIRGHLGDRPQC 734
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Fly
Match: Xpd (gene:FBgn0261850 transcript:FBtr0071576) HSP 1 Score: 189.889 bits (481), Expect = 2.551e-50 Identity = 174/736 (23.64%), Postives = 319/736 (43.34%), Query Frame = 1
Query: 115 VTFPIEP-YPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMS---------ILSGRNLSCLNQEVLMSKE---IDQNCKDL-----------------CKKM-GCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFI---------------MLVKLMMDSDKTKQNDFSIVI---TEGEKYA-------EPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVK--DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL-LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKID 2136
V FP E YP+Q M + S++ +CL+E+P+G+GKT LL + ++ ++ + K+ + +RT +I +VI EL+ R +LS R C++ EV +E +D C L C+ G + P + I+ + + CPYF + + A IV Y+Y+L+P I + + + + ++ DEAHNI+++C + S+ I+ + ++ L H L K ++ + D + E+ +++ L +D D++ L + V L + ++ N +F + L + I+ + E P+ F++ I S I L++ + SD T+ +++ T Y EP ++K + +N +L+ C++ I + +++++TSGTLSP+ + K L+ F + + + + L + G + + F T + GQ+L++ ++ VP+GI+ F +S+ +E + W + G+++ + ++K +FIE + +E + + Y K GA+LLAV RGK SEGVDF R V+ GIPY + +++Y DQ + N++ A R Q +GR +R + D+G MI D R S L WIQ+ +D
Sbjct: 10 VYFPYEYIYPEQYAYMLELKRSLDAKGHCLLEMPSGTGKTATLLSLIVAYMVEHPETVR---------------KLIYCSRTVPEIEKVIAELQNLMVYYERHCPNPPPFTGLVLSSRKNMCIHPEVSKEREGKAVDGKCYGLTASYIRERHEMDTETPICQYFEGFSLEGKESTLPVGVYSIDDLKEYGRSRNWCPYFLARYAIAHAHIVVYSYHYLLDPKIAQVVSKEMSRESCVVFDEAHNIDNVCIDSMSVKINRRTVERSTNALNH-LTKLVQDIREEDTNRLNEEYQRMVQGLKDASVQRDTDMILANPVLPNDV-LTEVVPGNIRNADHFLSFLRRFIEYIKTRLRVHHVVQESPAGFLKDISSKICIERKPLRFCAERLSSLLRTLEISDLTEYGALTLITHFATLVSTYTKGFTIIIEPFDDKTPT--------------VSNPILHFSCLDSSIAMAPVFSRFQTVVITSGTLSPMDMYPKILD--FDPVVMSSFTMTLARPCLLPMIVSKGNDQVTISSKFETREDTAVIRNYGQLLVEVAKTVPDGIVCFFTSYLYLESVVASWYDQGIVDTLLRYKLLFIETQDNAETSYALMNYVKACDCGRGAVLLAVARGKVSEGVDFDHHYGRAVLMFGIPYVYTQSRILKARLDY-------LRDQFQIRENDFLTFDAMRHAAQCVGRALRGKTDYGIMIFADKRF--SRHDKRSRLPKWIQEHLVD 703
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Fly
Match: CG11403 (gene:FBgn0026876 transcript:FBtr0070245) HSP 1 Score: 135.576 bits (340), Expect = 2.369e-32 Identity = 85/287 (29.62%), Postives = 145/287 (50.52%), Query Frame = 1
Query: 1303 VLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKEL--NCKFSAIFQ-AGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL--LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKID 2136
L ++P F I +R+I++ GT+ P +++L C + + HVV + I NGPSG + F+ EL +L +VVP G++ FL S+ ++ + +G + I KS+F E ++E + +D Y +K GALLL+V GK SEG++FAD+ R V+ VG+PY + P++ +M +H D++L +GNE+Y +A+NQ +GR +RH +D+ + ++D R ++P G L WI + ++
Sbjct: 564 TLKYILLDPAEQFADIVAEARAIVIAGGTMQPTKELKEQLFTGCHDRLVERFYNHVVANDAILPFVISNGPSGAPLSFKFAHRGSAEMLRELSMILRNLCQVVPGGVVCFLPSYEYLDKVYKYLEQSGTLETISGRKSVFREVSGSAE--QLLDNYALAIKRPASYGALLLSVVGGKLSEGLNFADDLGRAVLVVGLPYSNSLSPELRQRM-------QHLDEKLGPGAGNEYYENLCVKAVNQCIGRAVRHIKDYACVYLLDKRF--ADPKIRGKLPKWISRHIVE 839 HSP 2 Score: 58.151 bits (139), Expect = 2.891e-8 Identity = 49/200 (24.50%), Postives = 91/200 (45.50%), Query Frame = 1
Query: 301 NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSI-LSGRNLSCLNQEVLMSKEI---DQNCKDLCKKMG-----------------CIYKIDNQPHP------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKM 819
+ ++ + V+IFF +RTH Q+ Q++ EL+K+ + + SI L R C N V K + ++ C D+ K C +K + DIE ++ + C Y+ +S ++ A ++ PY +L R +G++L+ +I+I+DEAHN+ D + IS + ++ K+
Sbjct: 178 QEAAEDRYRPVQIFFCSRTHSQLAQIVAELRKTPHGQSVRSISLGSRQQLCGNPAVRKLKHVGLMNERCLDMATKKARPNPSKKSRLTAEANSRCPFKAASLVESLRDLALTEPLDIEELANEGTACGGCSYYASRSAVEHAQLILLPYQLLLQKSARNQLGISLKGSIVIVDEAHNLLDSVAQLHGSEISRQQLERAKV 377
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 409.838 bits (1052), Expect = 3.070e-127 Identity = 224/629 (35.61%), Postives = 346/629 (55.01%), Query Frame = 1
Query: 334 KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRV---NG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV--LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV---------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+ C+ ++K+ +Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ + + + ++ + + D LL + ++ L ++ + K W + + + + + + +LA L E RV NG E T I S+ ++ S M+++ + + +D+ + + + + + A G + +R+ V L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ +IG GP G + A F +FQDE+G +LLK V G+L FL S+ +++ RWTNTGL +++ + K++ EPR + +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W+++
Sbjct: 272 KIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVVPHANRNERCKEFLEAKNGRSCRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLKEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRRDQHRPLLAFCCSLTNWVQESCGGLEEREYESSCKVWTGVEVLGIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFLFRQNCRFADDYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAK--SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 898 HSP 2 Score: 72.7886 bits (177), Expect = 1.259e-12 Identity = 30/58 (51.72%), Postives = 40/58 (68.97%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
VE+ + V + FP + YP QL MM II +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 6 VEYTIGGVKINFPCKAYPSQLAMMNSIIRGLNNGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 409.838 bits (1052), Expect = 4.304e-127 Identity = 224/629 (35.61%), Postives = 346/629 (55.01%), Query Frame = 1
Query: 334 KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRV---NG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV--LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV---------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+ C+ ++K+ +Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ + + + ++ + + D LL + ++ L ++ + K W + + + + + + +LA L E RV NG E T I S+ ++ S M+++ + + +D+ + + + + + A G + +R+ V L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ +IG GP G + A F +FQDE+G +LLK V G+L FL S+ +++ RWTNTGL +++ + K++ EPR + +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W+++
Sbjct: 273 KIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVVPHANRNERCKEFLEAKNGRSCRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLKEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRRDQHRPLLAFCCSLTNWVQESCGGLEEREYESSCKVWTGVEVLGIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFLFRQNCRFADDYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAK--SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 899 HSP 2 Score: 72.7886 bits (177), Expect = 1.309e-12 Identity = 30/58 (51.72%), Postives = 40/58 (68.97%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
VE+ + V + FP + YP QL MM II +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 6 VEYTIGGVKINFPCKAYPSQLAMMNSIIRGLNNGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 409.453 bits (1051), Expect = 4.522e-127 Identity = 224/629 (35.61%), Postives = 346/629 (55.01%), Query Frame = 1
Query: 334 KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRV---NG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV--LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV---------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+ C+ ++K+ +Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ + + + ++ + + D LL + ++ L ++ + K W + + + + + + +LA L E RV NG E T I S+ ++ S M+++ + + +D+ + + + + + A G + +R+ V L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ +IG GP G + A F +FQDE+G +LLK V G+L FL S+ +++ RWTNTGL +++ + K++ EPR + +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W+++
Sbjct: 272 KIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVVPHANRNERCKEFLEAKNGRSCRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLKEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRRDQHRPLLAFCCSLTNWVQESCGGLEEREYESSCKVWTGVEVLGIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFLFRQNCRFADDYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAK--SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 898 HSP 2 Score: 72.7886 bits (177), Expect = 1.327e-12 Identity = 30/58 (51.72%), Postives = 40/58 (68.97%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
VE+ + V + FP + YP QL MM II +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 6 VEYTIGGVKINFPCKAYPSQLAMMNSIIRGLNNGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 409.838 bits (1052), Expect = 4.690e-127 Identity = 224/629 (35.61%), Postives = 346/629 (55.01%), Query Frame = 1
Query: 334 KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRV---NG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV--LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV---------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+ C+ ++K+ +Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ + + + ++ + + D LL + ++ L ++ + K W + + + + + + +LA L E RV NG E T I S+ ++ S M+++ + + +D+ + + + + + A G + +R+ V L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ +IG GP G + A F +FQDE+G +LLK V G+L FL S+ +++ RWTNTGL +++ + K++ EPR + +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W+++
Sbjct: 272 KIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVVPHANRNERCKEFLEAKNGRSCRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLKEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRRDQHRPLLAFCCSLTNWVQESCGGLEEREYESSCKVWTGVEVLGIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFLFRQNCRFADDYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAK--SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 898 HSP 2 Score: 72.7886 bits (177), Expect = 1.287e-12 Identity = 30/58 (51.72%), Postives = 40/58 (68.97%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
VE+ + V + FP + YP QL MM II +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 6 VEYTIGGVKINFPCKAYPSQLAMMNSIIRGLNNGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 409.838 bits (1052), Expect = 4.690e-127 Identity = 224/629 (35.61%), Postives = 346/629 (55.01%), Query Frame = 1
Query: 334 KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRV---NG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV--LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV---------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+ C+ ++K+ +Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ + + + ++ + + D LL + ++ L ++ + K W + + + + + + +LA L E RV NG E T I S+ ++ S M+++ + + +D+ + + + + + A G + +R+ V L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ +IG GP G + A F +FQDE+G +LLK V G+L FL S+ +++ RWTNTGL +++ + K++ EPR + +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W+++
Sbjct: 272 KIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVVPHANRNERCKEFLEAKNGRSCRYYHNVHKMRDQSTLQWVHGLHQAWDIEELVRLGGKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLKEQIVVLDEAHNIEDCARESASFTLNQAQLLLARDEIDGMVTHNIRRDQHRPLLAFCCSLTNWVQESCGGLEEREYESSCKVWTGVEVLGIFRGLGITADTFPLLQKNLAAVLEKEERVGLVNGREETVQVPTISSNTQSMLKSLFMVLEFLFRQNCRFADDYRVALQQSYMWTTQQDLPDAQGFFARPHRRRQSNRTKTLVHTLSFWCLNPAVAFSDLSSTVRSIVLTSGTLSPMGSFSSELGIKFSIQLEANHVINKSQVWVGTIGAGPQGRKLCATFQHAETFAFQDEVGALLLKVCHTVSRGVLCFLPSYKMLDKLRDRWTNTGLWDKLEECKTVITEPRGGGKGDFDELLQTYYEAIRGTAAKGEKRDGALLVAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDKHAK--SRGLLPGGRWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRTNPNKYITGLSKWVRQ 898 HSP 2 Score: 72.7886 bits (177), Expect = 1.287e-12 Identity = 30/58 (51.72%), Postives = 40/58 (68.97%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
VE+ + V + FP + YP QL MM II +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 6 VEYTIGGVKINFPCKAYPSQLAMMNSIIRGLNNGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Match: phlpp2 (PH domain and leucine rich repeat protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-964802]) HSP 1 Score: 404.831 bits (1039), Expect = 5.438e-127 Identity = 226/631 (35.82%), Postives = 357/631 (56.58%), Query Frame = 1
Query: 316 ENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQ------PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNE----IRVNGE--ITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALN-NNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV-----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
E K KIFFGTRTHKQI Q+ REL+++AYS+ RM+ILS R +C++ ++ ++ ++ CK+L C+ + K++ Q + WDIE + K+++ CPYF + M+ ADIVFCPYNY+L+ IR+SM + LE ++ILDEAHNIED RE AS S S + + Y + + ++ + L + + I S +L ++ + K W+ + + + + + + +LA + + ++G+ + + P + M L F++L L +++ + D+ I + + +A + +G + + R+A + LN WC+NP + F +S +R+I+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T FQDE+G +LL + V +G+L FL S+ ++E RW +TGL + + K++ EP+ ++ ++ + Y+ + KDGALL+AV RGK SEG+DF+D AR V+TVGIP+P+I D +V LK YN K LL G++WY IQA+RALNQALGRCIRH+ DWGA+I++D R SNP Y GL W+++
Sbjct: 236 EKPKVPKIFFGTRTHKQIAQITRELRRTAYSSVRMTILSSREHTCVHPDIHSNR--NEKCKELLEAKDGHSCRFYHGVQKMNEQNLLKYRHGVDKAWDIEELVGLGKRLRACPYFAARELMQEADIVFCPYNYLLDSQIRESMDIFLEGQVVILDEAHNIEDCARESASFSCSDEQLMYARDEIDSMVNHGIRVSDHEPLRAVCYSLTNWIRECSDQLVEREYEASCKVWNGKEILAIFHDMGITNATFPLLKANLAAVVEKEEKITMLHGQENVIKIPTLSPQTQMVLKGLFLVLDYLFRQNNRFAE-DYRIALQQSYTWANRQDIPDENGFFARPRNRRAVRQKIMVYTLNFWCLNPAVAFSDLSSNARTIVLTSGTLSPMGSFSSELGVKFSIQLEANHVIHKSQVWVGTVGAGPKGRKLCATFQHTETFDFQDEIGALLLSVCQTVSHGVLCFLPSYKMLEKLKDRWMHTGLWENLERIKTVIKEPQGGDKTDFDKMLQMYYDAIRYKGEKDGALLIAVCRGKVSEGLDFSDNNARAVVTVGIPFPNIKDLQVELKRKYNDQHAK--SRGLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFR-SNPKYITGLSKWVRQ 860 HSP 2 Score: 70.0922 bits (170), Expect = 1.031e-11 Identity = 32/85 (37.65%), Postives = 52/85 (61.18%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKI 339
+ E+ + V + FP YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W + + ++ +++E KE K ++
Sbjct: 5 LSEYTIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCLLESPTGSGKSLALLCSALAWQQSLYGKQAVDEKSNE-KECTKMERV 88
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Match: phlpp2 (PH domain and leucine rich repeat protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-964802]) HSP 1 Score: 400.979 bits (1029), Expect = 4.679e-126 Identity = 226/636 (35.53%), Postives = 357/636 (56.13%), Query Frame = 1
Query: 307 ECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQ------PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNE----IRVNGE--ITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALN-NNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV-------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
E E K KIFFGTRTHKQI Q+ REL+++AYS+ RM+ILS R +C++ ++ ++ ++ CK+L C+ + K++ Q + WDIE + K+++ CPYF + M+ ADIVFCPYNY+L+ IR+SM + LE ++ILDEAHNIED RE AS S S + + Y + + ++ + L + + I S +L ++ + K W+ + + + + + + +LA + + ++G+ + + P + M L F++L L +++ + D+ I + + +A + +G + + R+A + LN WC+NP + F +S +R+I+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T FQDE+G +LL + V +G+L FL S+ ++E RW +TGL + + K++ EP+ ++ ++ + Y+ + K GALL+AV RGK SEG+DF+D AR V+TVGIP+P+I D +V LK YN K LL G++WY IQA+RALNQALGRCIRH+ DWGA+I++D R SNP Y GL W+++
Sbjct: 181 ENGEKPKVPKIFFGTRTHKQIAQITRELRRTAYSSVRMTILSSREHTCVHPDIHSNR--NEKCKELLEAKDGHSCRFYHGVQKMNEQNLLKYRHGVDKAWDIEELVGLGKRLRACPYFAARELMQEADIVFCPYNYLLDSQIRESMDIFLEGQVVILDEAHNIEDCARESASFSCSDEQLMYARDEIDSMVNHGIRVSDHEPLRAVCYSLTNWIRECSDQLVEREYEASCKVWNGKEILAIFHDMGITNATFPLLKANLAAVVEKEEKITMLHGQENVIKIPTLSPQTQMVLKGLFLVLDYLFRQNNRFAE-DYRIALQQSYTWANRQDIPDENGFFARPRNRRAVRQKIMVYTLNFWCLNPAVAFSDLSSNARTIVLTSGTLSPMGSFSSELGVKFSIQLEANHVIHKSQVWVGTVGAGPKGRKLCATFQHTETFDFQDEIGALLLSVCQTVSHGVLCFLPSYKMLEKLKDRWMHTGLWENLERIKTVIKEPQGGDKTDFDKMLQMYYDAIRYKGEKGKYGALLIAVCRGKVSEGLDFSDNNARAVVTVGIPFPNIKDLQVELKRKYNDQHAK--SRGLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFR-SNPKYITGLSKWVRQ 810 HSP 2 Score: 68.5514 bits (166), Expect = 3.172e-11 Identity = 28/61 (45.90%), Postives = 40/61 (65.57%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
+ + E+ + V + FP YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 3 SALSEYTIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Match: phlpp2 (PH domain and leucine rich repeat protein phosphatase 2 [Source:Xenbase;Acc:XB-GENE-964802]) HSP 1 Score: 403.675 bits (1036), Expect = 1.582e-124 Identity = 228/634 (35.96%), Postives = 358/634 (56.47%), Query Frame = 1
Query: 307 ECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQ------PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNE----IRVNGE--ITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALN-NNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
E E K KIFFGTRTHKQI Q+ REL+++AYS+ RM+ILS R +C++ ++ ++ ++ CK+L C+ + K++ Q + WDIE + K+++ CPYF + M+ ADIVFCPYNY+L+ IR+SM + LE ++ILDEAHNIED RE AS S S + + Y + + ++ + L + + I S +L ++ + K W+ + + + + + + +LA + + ++G+ + + P + M L F++L L +++ + D+ I + + +A + +G + + R+A + LN WC+NP + F +S +R+I+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T FQDE+G +LL + V +G+L FL S+ ++E RW +TGL + + K++ EP+ ++ ++ + Y +K KDGALL+AV RGK SEG+DF+D AR V+TVGIP+P+I D +V LK YN K LL G++WY IQA+RALNQALGRCIRH+ DWGA+I++D R SNP Y GL W+++
Sbjct: 243 ENGEKPKVPKIFFGTRTHKQIAQITRELRRTAYSSVRMTILSSREHTCVHPDIHSNR--NEKCKELLEAKDGHSCRFYHGVQKMNEQNLLKYRHGVDKAWDIEELVGLGKRLRACPYFAARELMQEADIVFCPYNYLLDSQIRESMDIFLEGQVVILDEAHNIEDCARESASFSCSDEQLMYARDEIDSMVNHGIRVSDHEPLRAVCYSLTNWIRECSDQLVEREYEASCKVWNGKEILAIFHDMGITNATFPLLKANLAAVVEKEEKITMLHGQENVIKIPTLSPQTQMVLKGLFLVLDYLFRQNNRFAE-DYRIALQQSYTWANRQDIPDENGFFARPRNRRAVRQKIMVYTLNFWCLNPAVAFSDLSSNARTIVLTSGTLSPMGSFSSELGVKFSIQLEANHVIHKSQVWVGTVGAGPKGRKLCATFQHTETFDFQDEIGALLLSVCQTVSHGVLCFLPSYKMLEKLKDRWMHTGLWENLERIKTVIKEPQGGDKTDFDKMLQMYYDAIRYKGEKDGALLIAVCRGKVSEGLDFSDNNARAVVTVGIPFPNIKDLQVELKRKYNDQHAK--SRGLLPGSQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFR-SNPKYITGLSKWVRQ 870 HSP 2 Score: 70.0922 bits (170), Expect = 1.131e-11 Identity = 32/85 (37.65%), Postives = 52/85 (61.18%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKI 339
+ E+ + V + FP YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W + + ++ +++E KE K ++
Sbjct: 5 LSEYTIGGVKILFPCRAYPSQLAMMNSIMRGLNCKQHCLLESPTGSGKSLALLCSALAWQQSLYGKQAVDEKSNE-KECTKMERV 88
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414]) HSP 1 Score: 201.83 bits (512), Expect = 3.367e-54 Identity = 182/739 (24.63%), Postives = 337/739 (45.60%), Query Frame = 1
Query: 115 VTFPIEP-YPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK-SAYSNTR---------MSILSGRNLSCLNQEV---LMSKEIDQNCKDL-----------------CKKMGCIYKIDNQ-PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDL--ESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLI---------------DSFIMLVKLMMDSDKTKQN------DFSIVITEGEK----YAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL-LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKID 2136
V FP E YP+Q M + +++ + ++E+P+G+GKT++LL + + + Y ++ K+ + +RT +I +V+ EL+K Y+ + +++ S RNL C+N EV KEID C L C+ I + P P ++++ + ++ CPY+ + + ++V Y+Y+L+P I + L + ++++ DEAHNI+++C + S++I+ + ++ + + L + ++ + D + E+ +++E L ++ DV L E + + C + N +F L +L I+ T E P++F++ + + L + + +D T + +F+ +++ K EP ++ S +N VL+ C++ + K + +S+I+TSGTLSP+ + K L+ F + A + + L +G G AM + F T L+ G +LL+ S VVP+GI+ F +S+ +E + W G++ I+++K IFIE + +E + ++ Y + ++ GA+LL+V RGK SEG+DF R VI G+PY + +LK + + DQ L N++ A R Q +GR IR + D+G M+ D R S+ G L WIQ+ D
Sbjct: 10 VYFPYEYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEV---------------TKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALALSSRRNL-CVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNI-ETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC---IRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLSPLTLITNFATLVSTYTKGFMIIIEPFEDRTPS--------------ISNPVLHFSCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILD--FRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPY--VYTQSRILKA-----RLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDK--RGKLPLWIQEHLTD 703
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Match: ephx3 (epoxide hydrolase 3 [Source:Xenbase;Acc:XB-GENE-5900414]) HSP 1 Score: 200.29 bits (508), Expect = 1.004e-53 Identity = 178/716 (24.86%), Postives = 334/716 (46.65%), Query Frame = 1
Query: 115 VTFPIEP-YPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK-SAYSNTR---------MSILSGRNLSCLNQEV---LMSKEIDQNCKDL-----------------CKKMGCIYKIDNQ-PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDL--ESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMD--SDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL-LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKID 2136
V FP E YP+Q M + +++ + ++E+P+G+GKT++LL + + + Y ++ K+ + +RT +I +V+ EL+K Y+ + +++ S RNL C+N EV KEID C L C+ I + P P ++++ + ++ CPY+ + + ++V Y+Y+L+P I + L + ++++ DEAHNI+++C + S++I+ + ++ + + L + ++ + D + E+ +++E L ++ DV L E + + C + N +F L +L I+ T E P++F++ + + + + M +++ + ++ I + + P+ +S K L F + +C++ + K + +S+I+TSGTLSP+ + K L+ F + A + + L +G G AM + F T L+ G +LL+ S VVP+GI+ F +S+ +E + W G++ I+++K IFIE + +E + ++ Y + ++ GA+LL+V RGK SEG+DF R VI G+PY + +LK + + DQ L N++ A R Q +GR IR + D+G M+ D R S+ G L WIQ+ D
Sbjct: 10 VYFPYEYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGKTVSLLSLIVAYQRAYPLEV---------------TKLIYCSRTVPEIEKVVEELRKLIEYTQAQTGGTLNFMALALSSRRNL-CVNPEVSALRFGKEIDGRCHSLTASFVRSQKQRDPTVQTCRFFEEFDAIGRETPLPPGIYNLDDLRTLGRQKGWCPYYLARHALGQCNVVVYSYHYLLDPKIADLVSRELSKKSVVVFDEAHNIDNVCIDSMSVTITRRTLERCQTNI-ETLNTAIEKIKETDEKKLKEEYAQLVEGLREASVARETDVYLSNPVLPDEILQEAVPGC---IRNALHFLGFLRRLVGYIKSRLRAGHVTQEGPAAFLRDLYEKVCIERKPMRFCAERLRSLTRTLEIADITDLS-PLTLITNFATLVSTYT-KGIFLTVGFCV-FFCLDSSLAIKPVFQRFQSVIITSGTLSPLDIYPKILD--FRPVTMATFTMTLARVCLCPMVVGRGNDQVAMSSKFETREDLAVMRNYGNLLLEMSAVVPDGIVGFFTSYLYMENIVASWYEQGILENIQRNKLIFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPY--VYTQSRILKA-----RLQFLRDQFHLRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMLFADKRYARSDK--RGKLPLWIQEHLTD 691
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Match: Brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:MGI Symbol;Acc:MGI:2442836]) HSP 1 Score: 404.831 bits (1039), Expect = 1.816e-125 Identity = 233/649 (35.90%), Postives = 355/649 (54.70%), Query Frame = 1
Query: 265 KQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNG-EITDSTSEIP---SSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPIN--EKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
KQ +Q N+ + K+ KI+FGTRTHKQI Q+ REL+K+AYS M+ILS R+ SC++ EV+ + + C +L C ++KI NQ + WDIE + +K+K CPY+ + ++ ADIVFCPYNY+L+ IR++M + L+ ++ILDEAHNIED RE AS S++ + + + L ++ + ++ L + + +E S L + + K W + L + + HL A L+ E +V + +IP +S ++ M++ + + +D+ + I + + I +K KK + N LN WC+NP + F I+D R+I+LTSGTLSP+ SF EL FS +A HV+ + ++ ++G+GP G + A F T FQDE+G +LL + V GIL FL S+ L+E +RW TGL + + K++ EP+ + ++ +E + Y FK KDGALL+AV RGK SEG+DF+D+ AR VITVGIP+P++ D +V LK YN + K LL G +WY IQA+RALNQALGRCIRH+ DWGA+I++D R + + Y GL W++++
Sbjct: 225 KQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVN-ALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSK--SRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQ 870 HSP 2 Score: 70.8626 bits (172), Expect = 5.955e-12 Identity = 28/59 (47.46%), Postives = 40/59 (67.80%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
+ ++ + V + FP YP QL MM I+ +N S++CL+E PTGSGK++ALLCS L W
Sbjct: 5 LSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Match: Rtel1 (regulator of telomere elongation helicase 1 [Source:MGI Symbol;Acc:MGI:2139369]) HSP 1 Score: 336.265 bits (861), Expect = 1.770e-100 Identity = 225/733 (30.70%), Postives = 362/733 (49.39%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW---LKQYQSQLLLNSR-----------------------NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEI-------------PSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIV---ITEGEK---YAEPINEKVA--SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M L+ V V FP +PYP Q M +++ + K N ++E PTG+GKT+ LLCSTL W L+ S L + R + EC + KI + +RTH Q+ QVIREL+ +AY ++ +L R C++ EV +E + LC+K C + K Q DIE + K K+CPY+ ++ + ADI+F PYNY+L+ RK+ ++L+ ++I DEAHN+E IC E AS ++ +D+ ++ +L++ + Q +L + +++ SS L + ED+ K L + + QL D + +++ +L E ++ G I +S +I + +L+D +++++ D + + S+V I+ K + E + + A S W + RK VL+ WC +P ++ + R++ILTSGTL+P+ SF E+ F + H++ + ++ + GP G + + + LG+ L + VVP+G+L+F S+ ++E ++ W GL ++ K +F+EPR +E IDAY++ V +GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + + Q LSG EWY QA RA+NQA+GR IRHR D+GA+ + D R
Sbjct: 1 MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIP--KIIYASRTHSQLTQVIRELRNTAY-RPKVCVLGSREQLCIHPEV-KKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGEL-----QQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMD----IIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRK-----QGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Match: Rtel1 (regulator of telomere elongation helicase 1 [Source:MGI Symbol;Acc:MGI:2139369]) HSP 1 Score: 336.65 bits (862), Expect = 2.585e-100 Identity = 225/733 (30.70%), Postives = 362/733 (49.39%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW---LKQYQSQLLLNSR-----------------------NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEI-------------PSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIV---ITEGEK---YAEPINEKVA--SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M L+ V V FP +PYP Q M +++ + K N ++E PTG+GKT+ LLCSTL W L+ S L + R + EC + KI + +RTH Q+ QVIREL+ +AY ++ +L R C++ EV +E + LC+K C + K Q DIE + K K+CPY+ ++ + ADI+F PYNY+L+ RK+ ++L+ ++I DEAHN+E IC E AS ++ +D+ ++ +L++ + Q +L + +++ SS L + ED+ K L + + QL D + +++ +L E ++ G I +S +I + +L+D +++++ D + + S+V I+ K + E + + A S W + RK VL+ WC +P ++ + R++ILTSGTL+P+ SF E+ F + H++ + ++ + GP G + + + LG+ L + VVP+G+L+F S+ ++E ++ W GL ++ K +F+EPR +E IDAY++ V +GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + + Q LSG EWY QA RA+NQA+GR IRHR D+GA+ + D R
Sbjct: 1 MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIP--KIIYASRTHSQLTQVIRELRNTAY-RPKVCVLGSREQLCIHPEV-KKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGEL-----QQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMD----IIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRK-----QGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Match: Rtel1 (regulator of telomere elongation helicase 1 [Source:MGI Symbol;Acc:MGI:2139369]) HSP 1 Score: 336.265 bits (861), Expect = 3.574e-100 Identity = 225/733 (30.70%), Postives = 362/733 (49.39%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW---LKQYQSQLLLNSR-----------------------NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEI-------------PSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIV---ITEGEK---YAEPINEKVA--SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M L+ V V FP +PYP Q M +++ + K N ++E PTG+GKT+ LLCSTL W L+ S L + R + EC + KI + +RTH Q+ QVIREL+ +AY ++ +L R C++ EV +E + LC+K C + K Q DIE + K K+CPY+ ++ + ADI+F PYNY+L+ RK+ ++L+ ++I DEAHN+E IC E AS ++ +D+ ++ +L++ + Q +L + +++ SS L + ED+ K L + + QL D + +++ +L E ++ G I +S +I + +L+D +++++ D + + S+V I+ K + E + + A S W + RK VL+ WC +P ++ + R++ILTSGTL+P+ SF E+ F + H++ + ++ + GP G + + + LG+ L + VVP+G+L+F S+ ++E ++ W GL ++ K +F+EPR +E IDAY++ V +GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + + Q LSG EWY QA RA+NQA+GR IRHR D+GA+ + D R
Sbjct: 1 MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIP--KIIYASRTHSQLTQVIRELRNTAY-RPKVCVLGSREQLCIHPEV-KKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGEL-----QQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMD----IIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRK-----QGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Match: Rtel1 (regulator of telomere elongation helicase 1 [Source:MGI Symbol;Acc:MGI:2139369]) HSP 1 Score: 336.65 bits (862), Expect = 3.692e-100 Identity = 225/733 (30.70%), Postives = 362/733 (49.39%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW---LKQYQSQLLLNSR-----------------------NDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQL--DLENIKNFENHLAKLRNEIRVN----GEITDSTSEI-------------PSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIV---ITEGEK---YAEPINEKVA--SGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQ-ISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
M L+ V V FP +PYP Q M +++ + K N ++E PTG+GKT+ LLCSTL W L+ S L + R + EC + KI + +RTH Q+ QVIREL+ +AY ++ +L R C++ EV +E + LC+K C + K Q DIE + K K+CPY+ ++ + ADI+F PYNY+L+ RK+ ++L+ ++I DEAHN+E IC E AS ++ +D+ ++ +L++ + Q +L + +++ SS L + ED+ K L + + QL D + +++ +L E ++ G I +S +I + +L+D +++++ D + + S+V I+ K + E + + A S W + RK VL+ WC +P ++ + R++ILTSGTL+P+ SF E+ F + H++ + ++ + GP G + + + LG+ L + VVP+G+L+F S+ ++E ++ W GL ++ K +F+EPR +E IDAY++ V +GA LAV RGKASEG+DF+D R VI G+PYP DP+VVLKM + + Q LSG EWY QA RA+NQA+GR IRHR D+GA+ + D R
Sbjct: 1 MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIP--KIIYASRTHSQLTQVIRELRNTAY-RPKVCVLGSREQLCIHPEV-KKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGEL-----QQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMD----IIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRK-----QGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRF 715
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Match: sp|Q3YK19|FANCJ_CHICK (Fanconi anemia group J protein homolog OS=Gallus gallus OX=9031 GN=BRIP1 PE=2 SV=1) HSP 1 Score: 411.379 bits (1056), Expect = 1.649e-126 Identity = 243/666 (36.49%), Postives = 362/666 (54.35%), Query Frame = 1
Query: 292 NSRNDECKENAKQV---KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKM-------GCIY-----------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNGEITDSTSEIP--SSFMQLIDSFIMLVKLMMDSDKTK-QNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFV---LNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFID 2184
+S N + K N Q KIFFGTRTHKQI Q+ RELK++AYS M+ILS R+ +C++ V S + N +LC ++ C+Y + + + WDIE + KK++ CPYF + M ADIVFCPYNY+L+P IR+SM +NL+ ++ILDEAHNIED RE S S++ ++ + L ++ + ++ L M + + SS+L + K W + + + + + + HL A L E +++ + EIP SS Q++ + +V L + D ++ +D+ + + + + V+ K + L + V LN WC+NP + F ++D+ R+++LTSGTLSP+ SF EL KFS +A HV++ + ++ +IG GP+G + A F T FQDE+G +LL + V GIL FL S+ L++ RW +TGL + K++ EP+ S+ +E + Y FK KDGALL+AV RGK SEG+DF DE AR VIT+GIP+P++ D +V LK YN K LL G++WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL WI+++ N SL F +
Sbjct: 237 DSGNTKKKANGDQTFIPKIFFGTRTHKQIAQITRELKRTAYSGVPMTILSSRDYTCIHPVVSSS---NSNRNELCVELLEGKHGKSCLYYHGVHKLSEHYALQSAHNTYQAWDIEDLVSLGKKLRACPYFAARELMVGADIVFCPYNYLLDPQIRESMEINLKGQVVILDEAHNIEDSAREAVSYSVTESQLNAAREELDFMVNNNIRQKDHEQLRAMCCSLTNWLRESSSQLVETGYETSCKVWSGKEMLNHFHDMGITNISFPILQKHLSAVLEKEEKISMFGKEELVEIPIVSSATQIVLKGLFMVLLYLFKDNSRFADDYRVALQQTYAWTNDNQPDVSDTSAFFTKTKHKRNLRHKTVVHMLNFWCLNPAVAFSDLNDV-RTVVLTSGTLSPMDSFSSELGVKFSIQLEANHVIRNSQVWVGTIGTGPNGRKLCATFQHTETFEFQDEVGALLLSVCQKVGQGILCFLPSYKLLDKLKDRWIHTGLWRNLELVKTVIAEPQGGAKSDFDELLKIYYDAIKFKGEKDGALLIAVCRGKVSEGLDFCDENARAVITIGIPFPNVKDLQVELKRKYNDQHKT--TRGLLPGSQWYEIQAYRALNQALGRCIRHRSDWGALILVDDRFRNNPNKYITGLSKWIRQQVQHHENFGSALESLHAFAE 896 HSP 2 Score: 73.559 bits (179), Expect = 6.080e-12 Identity = 34/83 (40.96%), Postives = 53/83 (63.86%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQ-YQSQLLLNSRNDECKENA 324
+++ ++ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W + Y+ LL +S E +E A
Sbjct: 3 SDVSQYTIGGVKIMFPCKAYPSQLAMMNAIVKGLNNRQHCLLESPTGSGKSLALLCSALSWQQSLYEKSLLKSSCEKEDREPA 85
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Match: sp|Q9BX63|FANCJ_HUMAN (Fanconi anemia group J protein OS=Homo sapiens OX=9606 GN=BRIP1 PE=1 SV=2) HSP 1 Score: 409.838 bits (1052), Expect = 5.415e-126 Identity = 238/679 (35.05%), Postives = 373/679 (54.93%), Query Frame = 1
Query: 244 CSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPET------TWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNGEI-TDSTSEIP---SSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCK-KRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
CST KQ SQ N+ + +K KI+FGTRTHKQI Q+ REL+++AYS M+ILS R+ +C++ EV+ + ++ C +L C ++KI +Q +T WDIE + KK+K CPY+ + ++ ADI+FCPYNY+L+ IR+SM +NL+ ++ILDEAHNIED RE AS S++ + + + L ++ + ++ L + + +E + L +D + K W + L + + H A L+ E +++ + E+P +S ++ M++ + + +D+ I I + + I+ +G + K K+++ VLN WC+NP + F I+ ++I+LTSGTLSP+ SF EL F+ +A H+++ + ++ +IG+GP G + A F T FQDE+G +LL + V GIL FL S+ L+E +RW +TGL + + K++ +EP+ + + +E + Y +K KDGALL+AV RGK SEG+DF+D+ AR VIT+GIP+P++ D +V LK YN + K LL G +WY IQA+RALNQALGRCIRHR DWGA+I++D R + Y GL W++++ E SL F H +V
Sbjct: 219 CST----KQGNSQESSNTIKKDHTGKSKIPKIYFGTRTHKQIAQITRELRRTAYSGVPMTILSSRDHTCVHPEVVGNFNRNEKCMELLDGKNGKSCYFYHGVHKISDQHTLQTFQGMCKAWDIEELVSLGKKLKACPYYTARELIQDADIIFCPYNYLLDAQIRESMDLNLKEQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSMVNNNIRKKDHEPLRAVCCSLINWLEANAEYLVERDYESACKIWSGNEMLLTLHKMGITTATFPILQGHFSAVLQKEEKISPIYGKEEAREVPVISASTQIMLKGLFMVLDYLFRQNSRFADDYKIAIQQTYSWTNQIDISDKNGLLVLPKNKKRSRQKTAVHVLNFWCLNPAVAFSDINGKVQTIVLTSGTLSPMKSFSSELGVTFTIQLEANHIIKNSQVWVGTIGSGPKGRNLCATFQNTETFEFQDEVGALLLSVCQTVSQGILCFLPSYKLLEKLKERWLSTGLWHNLELVKTVIVEPQGGEKTNFDELLQVYYDAIKYKGEKDGALLVAVCRGKVSEGLDFSDDNARAVITIGIPFPNVKDLQVELKRQYNDHHSKLRG--LLPGRQWYEIQAYRALNQALGRCIRHRNDWGALILVDDRFRNNPSRYISGLSKWVRQQIQHHSTFESALESLAEFSKKHQKV 891 HSP 2 Score: 69.707 bits (169), Expect = 8.116e-11 Identity = 28/57 (49.12%), Postives = 39/57 (68.42%), Query Frame = 1
Query: 91 EFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
E+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 7 EYTIGGVKIYFPYKAYPSQLAMMNSILRGLNSKQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Match: sp|Q5SXJ3|FANCJ_MOUSE (Fanconi anemia group J protein homolog OS=Mus musculus OX=10090 GN=Brip1 PE=2 SV=1) HSP 1 Score: 404.831 bits (1039), Expect = 1.270e-124 Identity = 233/649 (35.90%), Postives = 355/649 (54.70%), Query Frame = 1
Query: 265 KQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIRVNG-EITDSTSEIP---SSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPIN--EKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAY-----FKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
KQ +Q N+ + K+ KI+FGTRTHKQI Q+ REL+K+AYS M+ILS R+ SC++ EV+ + + C +L C ++KI NQ + WDIE + +K+K CPY+ + ++ ADIVFCPYNY+L+ IR++M + L+ ++ILDEAHNIED RE AS S++ + + + L ++ + ++ L + + +E S L + + K W + L + + HL A L+ E +V + +IP +S ++ M++ + + +D+ + I + + I +K KK + N LN WC+NP + F I+D R+I+LTSGTLSP+ SF EL FS +A HV+ + ++ ++G+GP G + A F T FQDE+G +LL + V GIL FL S+ L+E +RW TGL + + K++ EP+ + ++ +E + Y FK KDGALL+AV RGK SEG+DF+D+ AR VITVGIP+P++ D +V LK YN + K LL G +WY IQA+RALNQALGRCIRH+ DWGA+I++D R + + Y GL W++++
Sbjct: 225 KQGNNQEPANTVKKDHGGQCKRPKIYFGTRTHKQIAQITRELRKTAYSGVPMTILSSRDHSCVHPEVVGNFNRKEKCMELLDGKHGKSCYFYHGVHKISNQQTLQHLQGMSRAWDIEELVSLGRKLKACPYYTARELIEDADIVFCPYNYLLDSQIRETMDIKLKGQVVILDEAHNIEDCARESASYSVTEVQLRFARDELDSLINGNIRKKSHEPLRDVCYNLINWLETNSKHLVERGYESSCKIWSGNEMLLNLYRMGITTATFPVLQRHLSAVLQKEEKVTPIHGKEEAIQIPIISASTQVVLKGLFMVLDYLFRENSRFADDYKVAIQQTYSWTNQIAIFDKTGVLAVPKNKKHSRQKIGVN-ALNFWCLNPAVAFSDINDKVRTIVLTSGTLSPLKSFSSELGVTFSIQLEANHVISNSQVWVGTVGSGPKGRNLCATFQHTETFEFQDEVGMLLLSVCQTVSQGILCFLPSYKLLEKLRERWIFTGLWHSLESVKTVIAEPQGGEKTDFDELLQVYYDAIKFKGEKDGALLIAVCRGKVSEGLDFSDDNARAVITVGIPFPNVKDLQVELKRQYNDHHSK--SRGLLPGRQWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFNNNPNRYISGLSKWVRQQ 870 HSP 2 Score: 70.8626 bits (172), Expect = 4.165e-11 Identity = 28/59 (47.46%), Postives = 40/59 (67.80%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
+ ++ + V + FP YP QL MM I+ +N S++CL+E PTGSGK++ALLCS L W
Sbjct: 5 LSDYTIGGVKIHFPCRAYPAQLAMMNSIVRGLNSSQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Match: sp|B3MSG8|RTEL1_DROAN (Regulator of telomere elongation helicase 1 homolog OS=Drosophila ananassae OX=7217 GN=GF20802 PE=3 SV=1) HSP 1 Score: 382.874 bits (982), Expect = 4.997e-118 Identity = 239/748 (31.95%), Postives = 385/748 (51.47%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK----QYQSQLL-----------LNSRNDECKENAKQV---------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCK-DLCK----KMGCIYKI---DNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQ------------HDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVA---SGEWISCKKRKADALNNNF-----VLNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY-NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNC 2148
M E ++ +PV FP EPYP Q M ++I + N ++E PTG+GKT++LLCS+L W++ ++Q Q++ E + AK + K+ + +RTH Q+ Q +RELK++AYSN R +L R+ C++ EV S+E+ + K ++CK C +++ + HP+ + DIE + +K+K+CPY+ K + ADI F PYNY+L+P RK+ + L N I+ILDEAHNIE IC E AS+ I D+ + HI+K + Q DL+ + E + ++ + + + D + T+ +LL N+ L KL + V + S + S L+ + +V +S K + V + E+ +P ++ +G W+S KA N + ++N WC NPG +Q+ + RS+ILTSGTL+P+ EL + + H+V + ++ IG GP + + ++ + LGQ +L S +VP+G+L+F S+ ++ + W +GL +I K IF+EPR + ++ +++ ++D GA +AV RGK SEG+DFAD R VI G+P+P + DPKV+LK Y +N+ + ++QLLSGNEWYN++A RA+NQA+GR IRHR D+GA+++ DSR + L WI+ D C
Sbjct: 1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIQCLKDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQQQMIKLDKGADLLGGGAGGGPELSDLAKTMGKANNWGVPKVIYASRTHSQLTQAMRELKRTAYSNMRSVVLGSRDQLCIHPEV--SREVGNSNKVNMCKLRVHSKTCTFQLRVESKKDHPDFRGPSIMDIEDLIKVGQKLKMCPYYASKELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAIAIEDVTHIMKAFASDSPQDMAGDEPKDFTIDDLMLLKEMLLDLEKAIDAVAV--DNPIDGATYPASMIYELLGKANFTYGNVATIVALLDKLVQYLMVASQQQMSLRKGGS--FTLLSDLLTIVFANKESVMGKVHASFKVHVQVEESKQPQGKQAPAKQAGGWLS----KASLTNGSTGKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQPLISNYTNRDNPKYISSLGQTILNVSRLVPDGLLVFFPSYPMLNKCVDAWQASGLWADIASKKPIFLEPRGKDQFTSTMEEFYQAIRDSKGACFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLESNRTR--ENQLLSGNEWYNLEATRAVNQAIGRVIRHRNDYGAILLCDSRFKDAAQVQQ--LSKWIRGHLGDRPQC 734
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Match: sp|B4PZB4|RTEL1_DROYA (Regulator of telomere elongation helicase 1 homolog OS=Drosophila yakuba OX=7245 GN=GE16425 PE=3 SV=1) HSP 1 Score: 378.637 bits (971), Expect = 1.792e-116 Identity = 236/749 (31.51%), Postives = 383/749 (51.13%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK----QYQSQLLLNSRND-----------ECKENAKQV---------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCK----KMGCIYKI---DNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILK--KSGK---------EDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKA-----------DALNNNFVLNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY-NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNC 2148
M E ++ +PV FP EPYP Q M ++I + N ++E PTG+GKT++LLCS+L W++ ++Q Q++ + D + E AK + K+ + +RTH Q+ Q +RELK++AY+N R +L R+ C++ EV M ++ + N ++CK C +++ + HP+ + DIE + +++KICPYF + + ADI F PYNY+L+P RK+ + L N I+ILDEAHNIE IC E AS+ I D+ + HI++ SG+ +D D LT+L++M E + ++ V T+ +LL N+ + L KL + V + ++ +F ML L+ K++ S V + + + K G+ K+ ++ ++N WC NPG +Q+ + RS+ILTSGTL+P+ EL + + H+V + ++ IG GP + + ++ + LGQ +L S +VP+G+L+F S+ ++ + W +GL +I K IF+EPR + ++ +++ ++D GA+ +AV RGK SEG+DFAD R VI G+P+P + DPKV+LK Y N+ + ++QLLSG EWYN+ A RA+NQA+GR IRHR D+GA+++ DSR ++ L WI+ D C
Sbjct: 1 MPESLIAGIPVHFPFEPYPVQRAYMEKVIQCLRDGTNGVLESPTGTGKTLSLLCSSLAWIRTRQSEHQQQMVKMEKADFTGLGGGAAGGDLSELAKTMGRANNWGVPKVIYASRTHSQLTQAMRELKRTAYANMRSVVLGSRDQLCIHPEV-MREQGNSNKTNMCKLRVHSKTCSFQMRVESRKDHPDLRGPSIMDIEDLVKVGQRLKICPYFASRELVPQADITFMPYNYLLDPKARKANKIELGNTIVILDEAHNIEKICEESASVQIKSSDVAMAIEDVTHIMQVFASGESQDMGGDEPKDFTLDDLTLLKEMLLEFEKAIDAVVVENA-VEGTTFPASMMYELLGKANFTYGNVATIVSLLDKLVQYLLVASQ---------QMTIRKGGTFTMLSDLLTIVFANKEDVMSKVYASFKVHVQLEEVKQGHGKQQGGKQHGGWLGKGTIAAATGSIKVAKIINFWCFNPGFGMEQLLNTQVRSVILTSGTLAPLKPLIAELAIPVAQHLENPHIVDQSQVYVKIIGTGPDRQQLISNYANRDNPKYISSLGQTILNVSRIVPDGLLVFFPSYPMLNKCVDAWQASGLWADISVKKPIFLEPRSKDQFTSTMEEFYQAIRDSKGAVFMAVCRGKVSEGLDFADRNGRAVIITGLPFPPLKDPKVILKRRYLEANRTR--ENQLLSGQEWYNLDATRAVNQAIGRVIRHRNDYGAILLCDSRFKDASQVQQ--LSKWIRGHLGDRPQC 734
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Match: A0A4E0RUG0 (Fanconi anemia group J protein OS=Fasciola hepatica OX=6192 GN=D915_007941 PE=4 SV=1) HSP 1 Score: 472.626 bits (1215), Expect = 2.675e-151 Identity = 270/828 (32.61%), Postives = 416/828 (50.24%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQY---QSQLLLNSRNDECKENAKQV---------------------------------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL----------CKKMGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLK-KTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSE-------IPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKY-------AEPINEKVASGEWISCKKRKADAL---NNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV---------------------------------------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL---------------------LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
++F + D+P+ FP +PY QL +M R+I ++ NCL+E PTG+GKT++LLC++L W+ + + + +D C NA V KI+F TRTHKQI QV+REL+K+ Y N +M+ILS R +C+N + S I + C++L +K + + N+ WDIE + L V CPYF + K+ADI+FCPYNY+L+P R + + L +I+ILDEAHNIED RE AS I+ + L +++K++ ++D L M+ + V++L S+L + E + W LL L E E KL + + N S++E + SS + L+ + +++ M ++ DF +V+ E Y + +NE S WIS + K N LN WC+NP IVF++++ ++ +IL SGTLSP+ + E EL F +A HV+ ++ F+AS+ +GP GN + A + S +FQDE+G ++L+ ++VP G+L FL S+ L++ +QRW TGL+ +R K + IEPR + ++ ++ ++ + ++GA++LAV RGK SEG+DFAD RLVI +GIPYP+ P+V K +N ++ QL LSG++WYN QA+RALNQALGRCIRH EDWGA+++ D+R Y G+ WI+ R N D V L+ FI+ +V
Sbjct: 1 MDFLIQDIPINFPYKPYGCQLSIMNRVIEALESKRNCLLESPTGTGKTLSLLCASLAWVNKKLVDRETVSAKGLDDHCANNAVDVHQALKNEKMLDSDASLSLYDDVQEEKENQPEIPKIYFCTRTHKQISQVVRELRKTKYRNAKMTILSSRQHTCINPAIRKSPNITEACQNLLQSGVCEFDQARKKSSLTRALNKLDAGGPWDIEDLVAALTPVPTCPYFCSRKLAKTADIIFCPYNYLLDPINRSATLIELNGHIVILDEAHNIEDASRESASFKITDHQLIKTNEDLENLIKQNLEKDSCEQLKCMIAAVLRVMQLTRSRLVHAGESTQPTQVWTGTEISGLLGTVGLGPEQFLCVERAYRKLSSAVTENPSEVPSSNENSENKLKLASSSLHLMQALFVVLGYMFRDNQKYLKDFRVVLMETVNYERKSTGCSAELNESPLSS-WISKRTNKTKTKLIENRELSLNFWCLNPAIVFREVASLAHCLILMSGTLSPLDALEAELGVDFPIRLEANHVIAKDRLFVASLAHGPGGNRLCATYQYQSTYAFQDEVGNLVLQACDIVPGGVLCFLPSYGLLDKLVQRWEATGLLENLRHVKHVMIEPRSSVGLDAWLEEFYAAIDQSENCGTPTRPRRRRCLKPGDTADNGNQIVAYPDLLDTQNGAIVLAVCRGKVSEGLDFADSYGRLVIAIGIPYPAFNSPQVQQKREFNDASRRLSASQLVAPHGQPQSPSTSSASISNCVLSGSDWYNAQAYRALNQALGRCIRHTEDWGAVLLADARFVEQPGRYLTGISRWIRSRVAHHNNWGDFAVRLRSFIETRTKV 827
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Match: A0A4S2MG60 (Helicase ATP-binding domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_000187 PE=4 SV=1) HSP 1 Score: 457.218 bits (1175), Expect = 1.623e-145 Identity = 260/819 (31.75%), Postives = 411/819 (50.18%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQ--YQSQL-------LLNSRNDECKENAKQV------------------------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLC----------KKMGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLK-KTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTS--------EIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGE-----WISCKKRKADALN-NNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD------------------------------GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFD---------------------------DQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
++F++ ++PV+FP +PY QL M R+I ++ NCL+E PTG+GKT++LLCS+L WL + ++L LNS + EN K+++ TRTHKQI Q++REL+K+ Y +M+ILS R +C+N V + I + C++L +K + + N + +WD+E + L +V CPYF + K+ADIVFCPY+Y+L+P R + ++L+ +++ILDEAHNIED RE S I+ + K L ++L+K+ + + DL+TMLE M V++L ++L + E + W + +L L E + E KL + E TD ++ SS + L ++ + ++ M D D+ V+ E Y E A + W+S + K+ + LN WC+NP +VF ++ R +IL SGTLSP+ + E EL F +A HV+ ++ ++++ +GP G + A F + FQDELG +LL+ +VP G+L FL S++L++ +QRW T L++++R+ K + +EPR + ++ + ++ V GAL+LAV RGK SEG+DFAD RLVI VGIPYP+ +P+V K +N + ++L+G+EWY+ QA+RALNQALGRCIRH DWGA++++D+R Y G+ WI+ R L L+ F+ H V
Sbjct: 1 MDFQIQNIPVSFPYKPYGCQLSCMNRVIEALESGRNCLIESPTGTGKTLSLLCSSLAWLNKRIVDTELDWSSNCDQLNSEQHDEVENGDTFLREKASPAVFASDQAGKNLESCLPKVYYCTRTHKQIAQLVRELRKTKYRKAKMTILSSRQHTCINPVVKKTSNITEACQNLLLNGFCEFDQPRKKSDLVRTINSLDSKGSWDLEDLVESLSQVPSCPYFCSRRLAKTADIVFCPYSYLLDPINRSATNLDLKGHVVILDEAHNIEDASREAGSFKITEHQLITTKDDLGNLLRKNVEPESCTDLITMLEGMLRVMQLTHTRLVHAGESAQPTQVWTGQEISGILSTVGLGPEKVTRMEMAYRKLSAYTSDSTEWTDRNGRSEGTEQPKLASSSLHLFEALFVALRYMFRDDSKHLGDYRFVLMETINYERQTTESSAEKDNSLNSWLSKRSAKSRYVEARELSLNFWCLNPSVVFSDLASEVRCLILVSGTLSPLEALEAELGVAFPIRLEAAHVIPKDRLLVSTLSHGPGGTRLCATFQNQNTFGFQDELGNLLLQACRLVPGGVLCFLPSYSLLDKLVQRWETTDLLSQLRQVKHVMLEPRSSVGLDSWLAEFYAAVDQSVMSLSRSPRHPVSTSSPASRCHSHSSQITGALVLAVCRGKVSEGLDFADAYGRLVIAVGIPYPAFNNPQVQQKREFNDRAHRSPGTLSIPPKIGPPTNAVASTPPSLSSPRITRVLTGSEWYDAQAYRALNQALGRCIRHLNDWGAILLVDARFVEQPSRYLAGISRWIRSRATLHTQWSTLASDLEQFVASHQAV 819
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Match: A0A1W2W4U1 (Fanconi anemia group J protein homolog OS=Ciona intestinalis OX=7719 GN=LOC100181276 PE=4 SV=1) HSP 1 Score: 454.136 bits (1167), Expect = 5.487e-141 Identity = 265/726 (36.50%), Postives = 388/726 (53.44%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK------QYQSQLLLNSRND----EC-------KENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMG-------CI-YKIDNQPHPETT---------WDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSE---IPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEP--RQTSEMNECIDAYFKHVK-------DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
VE + V + FP +PYP QL MM I+ + +SE+CL+E PTGSGKT++LLCS L W + Q + +L S D EC KE K I+FGTRTHKQI Q+ EL + Y + MSILS R +C++ SK ++ CK+L K + CI Y+ N+ + WD+E + +VK CPY+ + K+A I+FCPYNY+++P IR SM ++L+N+I+ILDEAHNIED RE AS + D+ L H++ + L +L KM + L + K W E F+ L + + + K + + + S + + ++ ++ S K D+ + + ++ P ++ G W++ KRK+ L+ WC+NP + F ++D +R IILTSGTLSP+ SF EL F +A HV+ + F+ S+G GP+G+ ++A + T+ L FQDELG+++ VVP G+L F SS+ ++E +RW NTGL +I + K I EP R ++ + + ++ V GAL LAV RGKASEG+DFA+ AR VITVGIP+P+ D +V LK YN + D LL+GN+WY IQAFRALNQALGRCIRHR DWGA+I++D R + Y GL W++++
Sbjct: 8 VELMIGGVKIHFPFKPYPSQLSMMSMIVKGLQRSEHCLLESPTGSGKTLSLLCSALAWQQDLAMRLQKKEELYEQSNVDCAEEECCSIEQPPKEKEKVPTIWFGTRTHKQIAQITHELATTQYRHVNMSILSSREHACIHPLNSQSKTKNEGCKELRKGIHPDLPGTHCIFYQNVNRLRSHASLKNCGITQAWDLEDLVKLGTRVKSCPYYAARELQKTASIIFCPYNYLIDPSIRSSMQIDLQNDIVILDEAHNIEDSSREAASFTAVETDLMSTVADLEHLISVESNVEEHQKLHLVLSKMGGWMNKHVKDLKESAYETWSKVWTGEDFIPHLDEWGITADTLSLLVEAFLKAVETKEEEEGGVEEEKKEMIMHSMSKSFLGALFDVLTYILASSKKFAGDYRVTMIRTAQFGIPPPKRTRDG-WVTINKRKSKFFL--LKLHFWCLNPAVAFTDLAD-TRCIILTSGTLSPMSSFSSELGLAFPIQLEAAHVISNSQVFVGSLGCGPNGHRLQATYQNTNSLDFQDELGKLVQSVCNVVPYGVLCFFSSYKMLEKLCERWKNTGLWYDICQKKEIVCEPHGRNKADFDGVLQNFYHTVAMVGTSDLTGALFLAVCRGKASEGLDFANNNARAVITVGIPFPNYRDKQVELKKTYNNFHCQ--DRGLLTGNDWYEIQAFRALNQALGRCIRHRNDWGALIIVDDRFCQNPRKYCKGLSKWVRQK 727
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Match: A0A0X3Q5H2 (Fanconi anemia group J protein homolog (Fragment) OS=Schistocephalus solidus OX=70667 GN=FANCJ PE=4 SV=1) HSP 1 Score: 443.736 bits (1140), Expect = 7.714e-140 Identity = 269/842 (31.95%), Postives = 419/842 (49.76%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK--------QY--------------------QSQLLLNSRNDE--------------------CKENAKQV------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMGCIYKIDNQP-------------HPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDI-----DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYK-DEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRV-NGEITDSTS---EIPSS-FMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEP------IN--EKVASGEWISCKKRKADAL----NNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHV---------------------KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYN---------------------------------TNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFI 2181
+E K+ V + P +PY QL M+ R+++++N + CL+E PTG+GKT+ALLC+TLGW++ QY S ++ + + DE C A++ +IFFGTRTHKQI QVIREL+K+ Y+NTRM ILS R +C+N +V I+ C +L + C Y +QP H WD+E +L KV +CPYF+ +++A IVFCPYNY+L+ +R + +LE +III+DEAHN+ED R+ S ++ KDI D K++ L+ KE+ Q LL +L +H V+++ S+L D W LL+ L + ++ + KL ++I NG S S E P+S ++L D L+ + + D+ V+TE Y +N E + W+S + + LN WC+NP + ++ + S+IL SGTL+P+ + EL +F +A HVV ++ F ASI GP G+ + A ++ + +FQD++G +++ +VP G+L F S+ L++ +QRW TG+++++ K K I EPR +S+ + + +++ + + GA+ LAV+RGK SEG+DFAD+ ARL+++VGIP+P+ +P+V K +N T ++LSG+EWY QA+RALNQALGRCIRHR DWGA+I+ D R Y G+ W++ + + + DL SL FI
Sbjct: 14 MELKVQGVKIHVPYKPYGCQLSMINRVVSALNDKKCCLLESPTGTGKTLALLCATLGWVENRMECLKEQYINMGDEGPCKACLNLTTNATTSTVVRSKQTDEWYEEFVEHDSAGIASFAEKRCTCGAQEALPERPPRIFFGTRTHKQISQVIRELRKTKYANTRMCILSSRTHTCINPDVRRQSNINDACANLTRMGTCPY---DQPKRRSDLTKCMEDLHRSGPWDLEEYVERLSKVPVCPYFRAWKLVETATIVFCPYNYLLDTVVRGKVASDLEGSIIIIDEAHNLEDAARDATSCTLLEKDILTATEDLHKLIR---LRPPEKENTQ-PLLNLLGSLHRVMDITRSRLVSAGDSANSSHVWTGSEIEGLLQTVGLGEDKFRSIRSCYQKLISKIPTSNGPSQQSFSPYLETPTSGTIRLFDYIFTLLGFLYGEEGHHMADYRAVLTEVVDYERTHGGDNGVNGLEHNSPARWLSKVTKSGSKSRLLESRTLSLNFWCLNPAVCMSSLASCAHSLILASGTLAPLDALAAELGLEFPVRLEANHVVSADRVFAASIARGPGGSRLLANYTNQNSFAFQDDIGSLIVGACRLVPGGVLCFFPSYGLLDKLVQRWELTGMLDKLAKVKHILQEPRTSSDFSAWMSEFYEAIDATRPSAGHSPRSLQDLGLPTQTGAVALAVYRGKVSEGLDFADDYARLIVSVGIPFPAFKNPQVEQKRRFNDALRATALTASNNVAPSLKVTTTTEVRTPGERETTAGPSRVRRVLSGSEWYEAQAYRALNQALGRCIRHRNDWGAIILADCRFTEQPTRYLSGVSRWLRNQVVAHQTWPDLTKSLSRFI 848
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Match: A0A0L7R388 (Fanconi anemia group J protein OS=Habropoda laboriosa OX=597456 GN=WH47_09825 PE=4 SV=1) HSP 1 Score: 437.958 bits (1125), Expect = 3.131e-137 Identity = 254/717 (35.43%), Postives = 387/717 (53.97%), Query Frame = 1
Query: 100 LSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQY-----QSQLLLNSRNDEC---------------------KENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMGCIYKIDNQ-------PHPE-----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTM-LEKMHEVIE--LLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNF----ENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGE----KYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----------GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
+S + V P++PY Q+ +M ++I K ENCL+E PTGSGKT+ALLC L W Y ++ L+ NSR + ++ K KI++GTRTHKQI QV+RELKK+ Y + +M+ILS R +C+ + ++ + D K+ C + DN P E WDIE + K +CPYF +S M+ ADI+FCPYNYI++P IR+S+ ++L++ +IILDEAHNIEDICRE AS++ + + K + +D + + ++K+ + ++ L Y +++ W +L +L F + +A L+ N + + S +++ +M M+ S++ ND+ +TE KYA W S KK++ A + L + CMNPG++F +++ +RSIIL SGTL+PV+SF+ ELN F + GHV+ E+ + + GP+G +KA + + FQDELG+ML+ E VP+G+L F SS+ ++ M RW + + N I K +FIEPR + ++ + Y + +++ GALLLAVFRGK +EG+DF D+ AR V+TVGIPY DP + +K+ YN K LL G++WY+IQAFRALNQALGRC+RH DWGA++++D R
Sbjct: 168 ISGIRVKLPVKPYSCQVAVMNKLIQGCVKKENCLLESPTGSGKTLALLCGVLAWHDHYVEGGSENVLINNSRENSITLFYSTFSSLSFFFWKLEEYRRKKLKIPKIYYGTRTHKQIEQVVRELKKTCYKHKKMTILSSREHTCIQESTRNKTDLCNDLLDPTKRQSCPFYNDNNKKTISSFPAVENRGLNAVWDIEDLVAIGKNEGLCPYFAARSLMEHADIIFCPYNYIVDPDIRESIQLDLKDQVIILDEAHNIEDICREVASVTFREDHLASTAHECESLAKTRAADFSVYDTIKVYIQKLVKFLKNIGLEKHRDYNSDNLSSPYWTGAELQELFNMHELGESAYLTFLAASKAAIADLKKAKEENKMFLKTVKPVISPSTKIVIEHLMFAIRMVTSEQY-MNDYRACVTETTVKDFKYA-------TDNTWYSAKKQEHRARS----LKLLCMNPGVIFSPLANNARSIILASGTLTPVLSFQSELNTPFVHVLNTGHVIPKEQVYATCVPKGPNGIYLKANYQNVNSWGFQDELGKMLVDVCESVPHGVLCFFSSYNVLHTQMDRWKSNFIWNRIASVKQVFIEPRYSGDLTAIMKEYREVIEETSSGPRGKINGALLLAVFRGKVAEGIDFKDDEARCVVTVGIPYGVRKDPVIDMKLKYNDMNVKR---GLLRGSDWYSIQAFRALNQALGRCLRHIHDWGAVLLVDERF 869
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:ZFIN;Acc:ZDB-GENE-081107-11]) HSP 1 Score: 363.999 bits (933), Expect = 1.593e-110 Identity = 223/660 (33.79%), Postives = 352/660 (53.33%), Query Frame = 1
Query: 244 CSTLGWLKQYQSQLLLNSRNDECKENAKQV--KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHPE------TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSIS----LKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHL-AKLRNEIR---VNG-EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNN-FVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPR--QTSEMNECIDAYFKHV-----KDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
C+TLG ++ + ++ E + N K+ KIFFGTRTHKQI Q+ RELK++ YS M+ILS R+ +C++ EV+ ++ CK+L C+ ++K+ Q + WDIE + K++ C Y+ + M+ A IVFCPYNY+L+P IR+SM +NL+ I++LDEAHNIED RE AS +++ L+ + ++ L+ + +++S E LL + ++ S L +D + K W +++ + + HL A L E R VNG E T I SS ++ S M+++ + + +D+ + + + ++ + A G + ++R+ L+ WC+NP +V +++ + + + S F L C F G ++ ++G GP G + A F T +FQDE+G +LLK + V G+L FL S+ L++ RW NTGL ++ + K++ EPR S+ +E + Y++ + +DGALL+AV RGK SEG+DF D+ AR V+TVGIP+P+I D +V LKM YN K LL G WY IQA+RALNQALGRCIRH+ DWGA+I++D R + Y GL W+++
Sbjct: 230 CATLGEAQKTGEKTKDKEKDKEKEGNMKKTVPKIFFGTRTHKQITQIARELKRTLYSTVPMTILSSRDHTCVHPEVMPHANRNERCKELLEAKNGLSCRFYHNVHKMREQSSLQWVHGLHQAWDIEELVRLGTKLRSCAYYAARELMQEACIVFCPYNYLLDPLIRESMEINLQGQIVVLDEAHNIEDCARESASFTLNQAQLLQAREEIESLVSYNIRRSNHE----PLLAFCCSLLNWVQESSGSLRERDYESACKVWTGREVLEIFHGFGITAATFPLLQKHLEAVLEKEERIGLVNGREDTVQVPTIASSTQSVLKSLFMVLEFLFRQNCRFADDYRVALQQSYIWSTQQDAPDAQGFFARPQRRRQTRTKTMVHTLSFWCLNPAVVSERLHIFFMHLGIMFSSTSLTHCFWITLCC-----FTPG-------VWVGTVGMGPQGRRLCATFQHTETFAFQDEVGALLLKVCQTVSRGVLCFLPSYKLLDKLRDRWMNTGLWEKLEECKAVITEPRGGAKSDFDELLQTYYEAIRQSGSRDGALLIAVCRGKVSEGLDFTDDNARAVVTVGIPFPNIKDLQVELKMKYNDQHSK--SRGLLPGGRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRFRSNPNKYITGLSKWVRQ 871 HSP 2 Score: 72.7886 bits (177), Expect = 1.160e-12 Identity = 29/60 (48.33%), Postives = 41/60 (68.33%), Query Frame = 1
Query: 82 NMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW 261
+ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCS L W
Sbjct: 4 STVEYTIGGVKINFPCKAYPSQLAMMNSIVRGLNHGQHCLLESPTGSGKSLALLCSALAW 63
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Match: rtel1 (regulator of telomere elongation helicase 1 [Source:NCBI gene;Acc:103025871]) HSP 1 Score: 336.265 bits (861), Expect = 1.638e-100 Identity = 221/741 (29.82%), Postives = 360/741 (48.58%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQV--------------------------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQ----NCKDLCKKMGCIY--KIDNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKD----IDYLKMLLPHILKKSGKEDCQHDLLTMLEKMH-----EVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNC-----QLDLENIKNFENHLAKLRNEIRVNGEITDSTS-EIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEP----INEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQI-SDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQ 2121
M L V V FP PYP Q M ++I + N ++E PTG+GKT+ LLC+TLGW + ++ + ++R K ++ KI + +RTH Q+ QV+ ELK +AY ++ +L R C+NQE+ M +E + C+ C++ +D + + + D+E + KK ++CPY+ +S + AD++F PYNY+L+P R++ + L+ ++I DEAHN+E +C E S ++ D ID + LL GK D D +E ++ ++ + K D ++ ++++ S Q + +L + NF+ A + ++ G + + +S +Q + I LV ++ ++ +K++ + + + + P +K ++ W S +K VL+ WC PG +++ R IILTSGTLSP+ SF E+ F + HV+Q ++ F++ + GP G + F LG ++ S VVP+G+L+F S+ +++ ++ W G + I K +F+EPR E ID ++ V D G AV RGKASEG+DFAD R VI G+P+P DP+VVLKM Y + K + LSG EWY QA RA+NQA+GR IRHRED+GA+ + D R N L W++
Sbjct: 1 MPVLSLRGVNVDFPFTPYPCQTDYMNKVIECLQSKVNGVLESPTGTGKTLCLLCATLGWREYFKDSI--SARKISEKMGGAELFPDRPMSSWGTAATDGDVPAYYTDIPKIIYASRTHSQLTQVVSELKNTAY-RPKVCVLGSREQLCINQEI-MKQESNHIKVHMCRAKVSTRSCLFYNNVDEKSTDKDIMNSILDVEDLVKTGKKERVCPYYLSRSLKQHADLIFMPYNYLLDPKSRRAHNIELKGAVVIFDEAHNVEKMCEESTSFDLTPYDLTSAIDAVDKLLREQASDIGKGDSSEDF--NVESLNSGLKLDITTIAKIKQILMDLELTINSFEMPSNNQGITKPGSYIYELFEKTHVNFDTKTAIVEAMEQITGYLAGKPGIFLNTSGLQKVADIIQLVFVVDPAEGSKKSQMVNSMKQFKVHIHPDTSNFKKKQSTDVWASSSAKK-----QGNVLSYWCFCPGFSMQELLRQEVRCIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQKDQIFVSIVDKGPDGVQLSTAFDKRFVPENMASLGNTIVNLSRVVPHGLLVFFPSYPVLDKTLEFWRANGHADRIENMKPMFVEPRGKGTFTEVIDGFYDKVNDPKSNGGSFFAVCRGKASEGLDFADTYGRGVIITGLPFPPRMDPRVVLKMQYLDEMCRNKSSGMKYLSGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRF--KNTDVRAQLPSWVR 728
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Match: rtel1 (regulator of telomere elongation helicase 1 [Source:NCBI gene;Acc:103025871]) HSP 1 Score: 336.265 bits (861), Expect = 3.028e-100 Identity = 221/741 (29.82%), Postives = 360/741 (48.58%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQV--------------------------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQ----NCKDLCKKMGCIY--KIDNQPHPE----TTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKD----IDYLKMLLPHILKKSGKEDCQHDLLTMLEKMH-----EVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNC-----QLDLENIKNFENHLAKLRNEIRVNGEITDSTS-EIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEP----INEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQI-SDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQ 2121
M L V V FP PYP Q M ++I + N ++E PTG+GKT+ LLC+TLGW + ++ + ++R K ++ KI + +RTH Q+ QV+ ELK +AY ++ +L R C+NQE+ M +E + C+ C++ +D + + + D+E + KK ++CPY+ +S + AD++F PYNY+L+P R++ + L+ ++I DEAHN+E +C E S ++ D ID + LL GK D D +E ++ ++ + K D ++ ++++ S Q + +L + NF+ A + ++ G + + +S +Q + I LV ++ ++ +K++ + + + + P +K ++ W S +K VL+ WC PG +++ R IILTSGTLSP+ SF E+ F + HV+Q ++ F++ + GP G + F LG ++ S VVP+G+L+F S+ +++ ++ W G + I K +F+EPR E ID ++ V D G AV RGKASEG+DFAD R VI G+P+P DP+VVLKM Y + K + LSG EWY QA RA+NQA+GR IRHRED+GA+ + D R N L W++
Sbjct: 1 MPVLSLRGVNVDFPFTPYPCQTDYMNKVIECLQSKVNGVLESPTGTGKTLCLLCATLGWREYFKDSI--SARKISEKMGGAELFPDRPMSSWGTAATDGDVPAYYTDIPKIIYASRTHSQLTQVVSELKNTAY-RPKVCVLGSREQLCINQEI-MKQESNHIKVHMCRAKVSTRSCLFYNNVDEKSTDKDIMNSILDVEDLVKTGKKERVCPYYLSRSLKQHADLIFMPYNYLLDPKSRRAHNIELKGAVVIFDEAHNVEKMCEESTSFDLTPYDLTSAIDAVDKLLREQASDIGKGDSSEDF--NVESLNSGLKLDITTIAKIKQILMDLELTINSFEMPSNNQGITKPGSYIYELFEKTHVNFDTKTAIVEAMEQITGYLAGKPGIFLNTSGLQKVADIIQLVFVVDPAEGSKKSQMVNSMKQFKVHIHPDTSNFKKKQSTDVWASSSAKK-----QGNVLSYWCFCPGFSMQELLRQEVRCIILTSGTLSPLSSFTCEMQIPFPVSLENPHVIQKDQIFVSIVDKGPDGVQLSTAFDKRFVPENMASLGNTIVNLSRVVPHGLLVFFPSYPVLDKTLEFWRANGHADRIENMKPMFVEPRGKGTFTEVIDGFYDKVNDPKSNGGSFFAVCRGKASEGLDFADTYGRGVIITGLPFPPRMDPRVVLKMQYLDEMCRNKSSGMKYLSGQEWYRQQASRAVNQAIGRVIRHREDYGAIFLCDHRF--KNTDVRAQLPSWVR 728
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920]) HSP 1 Score: 204.912 bits (520), Expect = 1.658e-55 Identity = 183/742 (24.66%), Postives = 334/742 (45.01%), Query Frame = 1
Query: 115 VTFPIEP-YPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK--------SAYSNTRMSI-LSGRNLSCLNQEV---LMSKEIDQNCKDL-----------------CKKMGCIYKIDNQ-PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDL--ESFVQLLKNCQLDLENIKNF-ENHLAKLRNEIRVNGEITDSTSEI-------------PSSF-----------MQLID----SFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL-LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKID 2136
V FP + YP+Q M + +++ + ++E+P+G+GKTI+LL + + K Y ++ K+ + +RT +I +V+ EL+K + N +++ LS R C++ EV KE+D C L C+ + Q P P ++++ + +K CPY+ + + A+IV Y+Y+L+P I + L + ++++ DEAHNI+++C + S++I+ + +D + + L+ + + + D + E+ ++E L ++ D+ L E + + E+ F + L L+ +R++ + +S+ + P F +++ D S I L+ T F+I+I EP +K + N VL+ CM+P I K + + +S+++TSGTLSP+ + + L+ F + A + +T L +G G AM + F T + G +LL+ S +VP+GI+ F +S+ +E + W G++ I+++K IFIE +E + ++ Y + ++ GA+LL+V RGK SEG+DF R VI G+PY + +LK + ++ DQ + N++ A R Q +GR IR + D+G MI D R ++ G L WIQ+ D
Sbjct: 10 VYFPYDYIYPEQYSYMLELKRTLDAKGHGVLEMPSGTGKTISLLSLIVAYQKAYPLEV---------------TKLIYCSRTVPEIEKVVEELRKLMEFYTKETGEKNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHHSNPSQPVCRFYEEFDAVGRQVPIPSGIYNLDDLKDFGRKKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNV-DTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKRFLEYLKARLRIHHVVQESSPQFLKDIYEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIII-------EPFEDKTPT--------------IANPVLHFSCMDPSIAIKPVFERFQSVVITSGTLSPLDIYPRILD--FRPVTMASFTMTLARTCLCPLIVGRGNDQVAMSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETPDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPY--VYTQSRILKA-----RLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADK--RGKLPRWIQEHISD 703
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Match: ercc2 (ERCC excision repair 2, TFIIH core complex helicase subunit [Source:NCBI gene;Acc:103044920]) HSP 1 Score: 196.823 bits (499), Expect = 5.322e-53 Identity = 176/723 (24.34%), Postives = 325/723 (44.95%), Query Frame = 1
Query: 157 MRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK--------SAYSNTRMSI-LSGRNLSCLNQEV---LMSKEIDQNCKDL-----------------CKKMGCIYKIDNQ-PHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDL--ESFVQLLKNCQLDLENIKNF-ENHLAKLRNEIRVNGEITDSTSEI-------------PSSF-----------MQLID----SFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL-LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
M + +++ + ++E+P+G+GKTI+LL + + K Y ++ K+ + +RT +I +V+ EL+K + N +++ LS R C++ EV KE+D C L C+ + Q P P ++++ + +K CPY+ + + A+IV Y+Y+L+P I + L + ++++ DEAHNI+++C + S++I+ + +D + + L+ + + + D + E+ ++E L ++ D+ L E + + E+ F + L L+ +R++ + +S+ + P F +++ D S I L+ T F+I+I EP +K + N VL+ CM+P I K + + +S+++TSGTLSP+ + + L+ F + A + +T L +G G AM + F T + G +LL+ S +VP+GI+ F +S+ +E + W G++ I+++K IFIE +E + ++ Y + ++ GA+LL+V RGK SEG+DF R VI G+PY + +LK + ++ DQ + N++ A R Q +GR IR + D+G MI D R ++ G L WIQ+
Sbjct: 1 MLELKRTLDAKGHGVLEMPSGTGKTISLLSLIVAYQKAYPLEV---------------TKLIYCSRTVPEIEKVVEELRKLMEFYTKETGEKNNFLALALSSRKNLCIHPEVSSLRFGKEVDGKCHSLTASYIRAQHHSNPSQPVCRFYEEFDAVGRQVPIPSGIYNLDDLKDFGRKKGWCPYYLARYSILHANIVVYSYHYLLDPKIADLVSKELAKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCQTNV-DTLQNTIQRIKETDAAKLREEYRRLVEGLKEANVARETDIYLSNPVLPDEVLQEAIPGSIRTAEHFVGFLKRFLEYLKARLRIHHVVQESSPQFLKDIYEKVCIDRKPLRFCAERLRSLLRTLEIADIADFSPITLISHFATLVSTYSKGFTIII-------EPFEDKTPT--------------IANPVLHFSCMDPSIAIKPVFERFQSVVITSGTLSPLDIYPRILD--FRPVTMASFTMTLARTCLCPLIVGRGNDQVAMSSKFETREDFAVIRNYGNLLLEMSAIVPDGIVAFFTSYVYMENIVASWYEQGILENIQRNKLIFIETPDAAETSMALEKYQEACENGRGAILLSVARGKVSEGIDFVHHFGRAVIMFGVPY--VYTQSRILKA-----RLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMIFADKRYARADK--RGKLPRWIQE 675
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009331.1 (pep scaffold:Pmarinus_7.0:GL478127:7852:42501:1 gene:ENSPMAG00000008437.1 transcript:ENSPMAT00000009331.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 164.466 bits (415), Expect = 4.164e-43 Identity = 80/232 (34.48%), Postives = 130/232 (56.03%), Query Frame = 1
Query: 1456 HVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQL------LSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQ 2121
HV+ + ++ + GP + + + S ++ LG+ ++ + ++PNG+L+F S+ ++++ +Q W N GL ++I + K +F+EP+Q E I+ ++ + D A AV RGK SEG+DFAD R VI G+P+P DP + LKM + K ++ LSG EWY QA RA+NQA+GR IRHR D+GA+I+ D R S+ + L W++
Sbjct: 9 HVIDKHQVWVGIVEKGPDSVQLNSAYRNRSCPAYMSSLGKTIVNLARIIPNGLLVFFPSYTVMDMCLQHWKNEGLSSKIEEIKPMFVEPKQKGLFTEAINGFYDKINDPRCSAAAFFAVCRGKVSEGLDFADANGRAVIITGLPFPPQMDPWIKLKMQFLDEMKAKRSTEMQCEFVGLSGQEWYTQQASRAVNQAIGRVIRHRHDYGAIILCDHRF--SSASAVAQLPSWMR 238
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Match: ercc2 (excision repair cross-complementation group 2 [Source:ZFIN;Acc:ZDB-GENE-040426-997]) HSP 1 Score: 164.466 bits (415), Expect = 1.454e-42 Identity = 173/743 (23.28%), Postives = 323/743 (43.47%), Query Frame = 1
Query: 199 LMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK-SAYSNTR---------MSILSGRNLSCLNQEV---LMSKEIDQNCKDLCKKMG------------CIYKID------NQPHPETTWDIESISMKLKKVKICPYFQFK-SWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLA-------KLRNEIRVNGEITDST---------------------SEIPSSFMQLID-------SFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFE-KELNCKFSAIFQAGHVV----QPEKTFLASI-GNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQV 2199
++E+P+G+GKT++LL + + + + +++ K+ + +RT +I +VI E+KK AY +S+ S +NL C++ EV KE+D C L C + D P P + ++ + ++ CPYF + S + A++V Y+Y+L+P I + + + ++++ DEAHNI+++C + S++I+ + +D + L+ + ++ + D + E+ ++E L ++ DV L ++L++ + N +N E+ ++ L++ +RV +++ST SE S ++ ++ S + LV T N F+++I EP +K + LN N + ++D S+ + GT + + F ++N +F+A+ V+ P + I G M + F T ++ G +LL+ + VVP+G++ F +S+ +E + W G++ I+++K IFIE + +E + ++ Y + ++ GA+LL+V RGK SEG+DF R VI GIPY + +LK + D + N++ A R Q +GR IR + D+G M+ D R ++ G L WIQ+ D +L L ID QV
Sbjct: 5 VLEMPSGTGKTVSLLALIVAYQRAFPNEVQ---------------KLVYCSRTVPEIEKVIEEMKKLVAYYEKHTKEPMKFLALSLSSRKNL-CIHPEVSALRFGKEVDGRCHSLTASYVRNRHSSDGSVPVCSFYEDFNTNGREVPMPPGIYSLDDLKEYGRQKHWCPYFLARYSQIMHANVVVYSYHYLLDPKIADLVSKEMSKKSVVVFDEAHNIDNVCIDSMSVNITRRTLDRCSTNI-ETLQTTIQKIRETDATKLKEEYRRLVEGLRDASVARETDVHLANPVLPD--EVLQDAEAVPGNSRNAEHFVSFLKRFVEYLKSRLRVTHVLSESTPAFLKETYDRICIDRKPLRFCSERLRSLLRTLEIADIADFSPLTLVCNFATLVSTYTNGFTLII-------EPFEDKTPT------------ILNPILRFRRHSKNQKLSVHMVNDTRASVNVPCGTRALLNRFPLDKVNTRFTALRCITGVLALTFSPNRGLAMKIVARGNDQVTMSSKFETREDIAVIRNYGNLLLEMTCVVPDGVVCFFTSYHYMESIVAAWYEQGILENIQRNKLIFIETQDGAETSVALEKYHEACENGRGAVLLSVARGKVSEGIDFVHHYGRAVIMFGIPY--VYTQSRILKARLEFLR----DHYQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGVMVFADKRYSRADK--RGKLPRWIQEHITD--------ANLNLTIDEALQV 693
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095]) HSP 1 Score: 148.288 bits (373), Expect = 2.610e-39 Identity = 90/283 (31.80%), Postives = 145/283 (51.24%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLL-----NSRNDECKENAKQV----------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIYKIDNQPHPETTW-----DIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSIS----LKDIDYLKMLLPHILKKSG 849
M + +PV+FP PY Q M ++I+ +N +N ++E PTG+GKT+ LLC+TL W + Q + NS D+ +E V KI + +RTH Q+ Q + ELK ++Y R+ +L R C++ +V+ +E + LC+ C Y +N +T + D+E + K KK ++CPYF + ADI+F PYNY+L+ R++ ++L I+I DEAHN+E +C AS ++ ID + L +K+ G
Sbjct: 1 MPVLTIGGIPVSFPFTPYKCQEDYMAQVIDCLNLGKNGILESPTGTGKTLCLLCATLAWREHQVGQHVRQREQQNSWGDDGREAEAAVTYPGGVGNIPKIIYSSRTHSQLSQAMNELKNASY-KPRVCVLGSREQLCIHPDVV-KQESNHAKVHLCRAKTTSRSCFY-YNNVEEKKTDFIAGIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDLSGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKVKEEG 280
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095]) HSP 1 Score: 147.902 bits (372), Expect = 2.979e-39 Identity = 90/286 (31.47%), Postives = 143/286 (50.00%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLL-----NSRNDECKENAKQV----------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKK----MGCIY--------KIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSIS----LKDIDYLKMLLPHILKKSG 849
M + +PV+FP PY Q M ++I+ +N +N ++E PTG+GKT+ LLC+TL W + Q + NS D+ +E V KI + +RTH Q+ Q + ELK ++Y R+ +L R C++ +V+ +E + LC+ C Y + P P D+E + K KK ++CPYF + ADI+F PYNY+L+ R++ ++L I+I DEAHN+E +C AS ++ ID + L +K+ G
Sbjct: 1 MPVLTIGGIPVSFPFTPYKCQEDYMAQVIDCLNLGKNGILESPTGTGKTLCLLCATLAWREHQVGQHVRQREQQNSWGDDGREAEAAVTYPGGVGNIPKIIYSSRTHSQLSQAMNELKNASY-KPRVCVLGSREQLCIHPDVV-KQESNHAKVHLCRAKTTSRSCFYYNNVEGECAVHLTPTP-GIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDLSGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKVKEEG 283
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Match: RTEL1-TNFRSF6B (RTEL1-TNFRSF6B readthrough (NMD candidate) [Source:HGNC Symbol;Acc:HGNC:44095]) HSP 1 Score: 135.961 bits (341), Expect = 2.025e-35 Identity = 93/325 (28.62%), Postives = 154/325 (47.38%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQV-------------------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVL-----MSKEIDQNCKDLCKK----MGCIYKID---------NQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILK-KSGKEDCQHD-----------LLTMLEKMHEVIEL 912
M + +PV+FP PY Q M ++I+ +N +N ++E PTG+GKT+ LLC+TL W + Q + R E + + + KI + +RTH Q+ Q + ELK ++Y R+ +L R C++ +V+ +K + LC+ C Y + +Q D+E + K KK ++CPYF + ADI+F PYNY+L+ R++ ++L I+I DEAHN+E +C AS ++ ++ + H L+ KS + HD LL LE+ +++EL
Sbjct: 1 MPVLTIGGIPVSFPFTPYKCQEDYMAQVIDCLNLGKNGILESPTGTGKTLCLLCATLAWREHQVGQ---HVRQREQQNSCTAISWSPRNQTLPVTGGVGNIPKIIYSSRTHSQLSQAMNELKNASY-KPRVCVLGSREQLCIHPDVVKQESNHAKVWNNRLVHLCRAKTTSRSCFYYNNVEVYCSLRASQRLAGRIMDVEELVKKGKKHQVCPYFMTQELKHDADIIFMPYNYLLDTKSRRAHSIDLSGKIVIFDEAHNVERLCENAASFDLTPFELASSIDAVSHFLQMKSRTQTVLHDVSIEDVANIKQLLLNLEREIDLVEL 321
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Yeast
Match: RAD3 (5' to 3' DNA helicase; involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000000973]) HSP 1 Score: 209.149 bits (531), Expect = 8.537e-58 Identity = 172/722 (23.82%), Postives = 338/722 (46.81%), Query Frame = 1
Query: 88 VEFKLSDVPVTFPIEP-YPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTR----------MSILSGRNLSCLNQEVLMSKE-----IDQNCK-------------------DLCKKMGCIYKIDNQPH-PETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNL-ENNIIILDEAHNIEDICREGASMSISL-------KDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLID--SFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRK----------ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQ-PEKTFLASI-GNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRL 2073
++F + D+PV FP YP+Q M I +++ N ++E+P+G+GKT++LL T+ + Y + KI + +RT +I + + EL+ T+ + + S +NL CL+ EV SKE +D+ C+ +LC+ +Y I+ + + P+ + E + ++ +CPYF + + +I+ Y+Y+L+P I + + + +++I+I DEAHNI+++C E S+ ++ + + L + + +K + Q + +++ +H L + + + VL + DL L + ++ ++F + L +L ++ ++ SE P SF+Q + +FI L S++ ++ +TE E + + + IS + +A N ++ C++ I K + + S+I+TSGT+SP+ + + LN F + Q + + +K+FL I G A+ + F + S G ML++ +++ P+G+++F S+ +E + W G+++E+ KHK I +E E + ++ Y K + GA+LL+V RGK SEG+DF + R V+ +GIP+ + ++ + + + N++ + A R Q LGR +R ++D+G M++ D R
Sbjct: 1 MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHY----------------PEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNL-CLHPEV--SKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEV-RKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQ--DL-----LTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFT-ALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLN--FKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYR------IRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRF 686
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Yeast
Match: CHL1 (Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome [Source:SGD;Acc:S000005929]) HSP 1 Score: 161.384 bits (407), Expect = 1.688e-41 Identity = 165/666 (24.77%), Postives = 294/666 (44.14%), Query Frame = 1
Query: 319 NAKQVKIFFGTRTHKQIGQVIRELKKSAYSNT----------RMSILSGRNLSCLNQEVLMSK---EIDQNCKDL-CKKMGCI-YKIDNQ-PH-PET----------TWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDE-DVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINE----KVAS-------GEWISCKKRKADA----LNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSA----IFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLS---FQDELGQMLLKCSEVVP--NGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDG--ALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLL--SGNEWYNIQA---------FRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQ 2121
N VKI++ +RT+ Q+GQ +L+ ++ ++ + L+ + C+N +V+ K I+ C DL K GCI Y+ N+ H P+T DIE + K + ICPY+ + + A++V PY Y+L+ R S+ +NLEN+I+I+DEAHN+ + S ISL+D+ ++C ++T K S+L + ++LK L + +Q + +KNF+ K+ EI N T S I + + + +I + K+ D Q ++ E K PI E V+S +++ C N+ + + P F+ I + ++ ++L GT+ P+ F L + + HV+ P++ I N P + F+ ++S + L Q + S+ VP GI+ F S+ + +Q W + + IF E + + ++ + Y V +G +LLLA+ GK SEG++F D+ R V+ VG+P+P+I ++++ K+KH +++ G E +A +A+NQ++GR IRH D+ + ++D R + P + L W+Q
Sbjct: 227 NQNPVKIYYASRTYSQLGQFTSQLRLPSFPSSFRDKVPDEKVKYLPLASKKQLCINPKVMKWKTLEAINDACADLRHSKEGCIFYQNTNEWRHCPDTLALRDMIFSEIQDIEDLVPLGKSLGICPYYASREALPIAEVVTLPYQYLLSESTRSSLQINLENSIVIIDEAHNLIETINSIYSSQISLEDL----------------KNCHKGIVTYFNK-------FKSRLNPGNRVNLLKLNSLLMTLIQFI---------VKNFK----KIGQEIDPNDMFTGSN--IDTLNIHKLLRYIKVSKIAYKIDTYNQ---ALKEEESSKNENPIKETHKKSVSSQPLLFKVSQFLYCLTNLTSEGQFFFEKNYSIKYMLLEPSKPFESILNQAKCVVLAGGTMEPMSEFLSNLLPEVPSEDITTLSCNHVI-PKENLQTYITNQP-----ELEFTFEKRMSPSLVNNHLFQFFVDLSKAVPKKGGIVAFFPSYQYLAHVIQCWKQNDRFATLNNVRKIFYEAK---DGDDILSGYSDSVAEGRGSLLLAIVGGKLSEGINFQDDLCRAVVMVGLPFPNIFSGELIV-------KRKHLAAKIMKSGGTEEEASRATKEFMENICMKAVNQSVGRAIRHANDYANIYLLDVRYN--RPNFRKKLSRWVQ 833
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Nematostella
Match: EDO39388 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SA32]) HSP 1 Score: 316.235 bits (809), Expect = 5.052e-94 Identity = 214/769 (27.83%), Postives = 356/769 (46.29%), Query Frame = 1
Query: 109 VPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSR----------------------------NDECK---ENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQN------CKDLCKKMGCIYKID---NQPHPETT---WDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFM---------------QLIDSFIMLVKLMMDSDKTKQ-------NDFSIVITEGEK------------YAEPINEKVASGE--WISCKKRKADALNNNF----------VLNIWCMNPGIVFKQI-SDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNY--NTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKR 2127
V V FP +PY Q+ M ++I + +N ++E PTG+GKT+ LLC+TL W + Y + L L R +D C N + KI + +RTH Q+ Q ++ELK + Y R+SI+ R C+N +VL D N C+ C + + N+ +P T DIE + +K K+CPY+ + SADI+F PYNY+L+P RK+ +++ +I++ DEAHN+E +C E S ++ DI C D+L +E + + D D+ + D+ D E++K + +KL EI +D + P FM +++++ + L+ + + K + IV + +K EP ++K G W S K ++ + +++ WC +PG K + S S+ILTSGTLSP+ SF E+ F + HV++ + +A + P G + + + S + LG + + +PNG+L+F S+ ++ ++ W NTG+ + ++K +F EPR + + ++ ++ + D GA AV RGK SEG+DF+D R V+ G+P+P + D KV LKM++ ++K + L+G EWY QA RA+NQA+GR IRHR+D+GA+++ D R + P L W++ +
Sbjct: 7 VDVDFPFKPYDCQVAYMEKVIECLQTRKNAVLESPTGTGKTLCLLCATLAWRQSYVANLQLQQRGLCAAKEEEDGFQKSLGNKLAEAASGTWDDSCSNKGSNFEIPKIIYASRTHSQLSQAVQELKATVY-RPRVSIIGSREQLCINSDVLKQ---DSNSAKVHMCRAKVTARTCHFYNNLEGNKSNPAFTTEILDIEDLVRLGQKHKVCPYYMARELKTSADIIFMPYNYLLDPKSRKAHNLDISGSIVVFDEAHNLEKVCEETVSFDLTSFDI----------------ASCVEDVLLCMEYVANAED---------DPDIGEGGTDI------------DPEDLKVLKALFSKLEEEIDQIQLPSDGSKSFPGDFMFELLGNVGIKPNTKDRVLETLEKINTLLANGLRGKHFALQKFTDALQIVFNKTDKGPKSGNSFKVHVQVEPDSKKKQKGLDIWTSGSKLSKKGTSSLYFYSFFMRTMIMIHYWCFSPGHAMKDLMSQGVSSVILTSGTLSPLNSFTAEMQIPFPIRLENPHVIEKHQMMVAVVTKAPDGATLNSSYEFRSTPGYMTGLGNTIANFARTIPNGLLVFFPSYPVMNKCLEHWQNTGIWARLSQYKPMFAEPRGKGDFVQTMEDFYAKINDPSLNGATFFAVCRGKVSEGLDFSDINGRAVVITGLPFPPMMDAKVKLKMSFLDEMSRKDKSAIKGLTGREWYRQQASRAVNQAVGRVIRHRQDFGAILLCDVRF--TYPDALRELPSWVKPQ 732
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Nematostella
Match: EDO46754 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNX6]) HSP 1 Score: 200.675 bits (509), Expect = 1.112e-54 Identity = 175/706 (24.79%), Postives = 320/706 (45.33%), Query Frame = 1
Query: 157 MRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKK-SAY--------SNTRMSILSGRNLSCLNQEVLMSKE---IDQNCKDLCKKMG------------CIYKID------NQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENN-IIILDEAHNIEDICREGASMSISLKDIDYLKM---LLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVK--LMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNF----------VLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLAS--IGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD--GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQK 2124
M + +++ +CL+E+P+G+GKT++LL + +LK +L K+ + +RT +I +V+ ELKK + Y N LS R C++ EV +E +D C + C + D ++ P +++++ + +K CPYF + + A+++ Y+Y+L+P I + L+ +++ DEAHNI+++C + S++IS + +D L ++ + D Q + E+ + ++E L +D D++ L V L ++ ++ ++F + + ++ I E P SF+Q I + + + L +++ ++ I E + Y P+ +S + + + F +L+ CM+ I K + D +S+++TSGTLSP+ + K L+ F + A + +T L + G AM F L+ G +L + S VVP+GI+ F +S+ +E + W + G+I+ I+K+K +FIE +E + + Y K ++ GA+LL+V RGK SEG+DF R VI GIPY + ++ Y ++ F+ + N++ A R Q +GR IR + D+G M+ D R S G L WIQ+
Sbjct: 1 MLELKRTLDAKGHCLLEMPSGTGKTVSLLSLIVAYLKNKPLEL---------------TKLIYCSRTVPEIEKVMEELKKLTEYYESETGEKPNILALALSSRKNLCIHPEVAGEREGKKVDGKCLSMTASFVRLKHKEDSSVPVCNFYEDFDSLGRDEKMPPGSYNLDDLRQFGRKKGWCPYFLARRAIYHANVIVYSYHYMLDPKIADLVSKELDKKAVVVFDEAHNIDNVCIDSMSVTISRRTLDRSHANVESLASVIDRIKATDAQK----LREEYNRLVEGLRQASEARDTDIVLSNPVLPDEV-LQESVPGNIRKAEHFVGFMRRFIEYLKTRLRIQHVVQESPMSFLQHIYQQVCIERKPLRFCAERLSSLLRTLEIPEMQDYG-PLVLIANFATLVSTYNKGFNIIIEPFDDRTPTIPNPILHFSCMDASIAVKPVFDRFQSVVITSGTLSPIDMYPKILD--FRPVTMATFTMTLARTCLCPMIVSRGSDQVAMTTKFEMREDLAVIRNYGNLLTEMSAVVPDGIVCFFTSYLYMESVVSLWHDQGIISNIQKNKLLFIETTDAAETSLALHNYQKACENGRGAILLSVARGKVSEGIDFDHHYGRAVIMFGIPYVYTQSRILKARLEY---LREQFN---IRENDFLTFDAMRHAAQCVGRAIRGKTDYGIMVFADKRF--SKVDKRGKLPKWIQE 675
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242]) HSP 1 Score: 403.675 bits (1036), Expect = 4.291e-123 Identity = 233/652 (35.74%), Postives = 356/652 (54.60%), Query Frame = 1
Query: 295 SRNDECKENAKQ-----VKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHP-------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSI---SLKDI-DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKV--ASGEWISCKKRK---ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTS--EMNECIDAYFKHVK-----DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPT-YSGGLCGWIQK 2124
S D KE AK KIFFGTRTHKQI Q+ ELK++ YS+ M+ILS R+ +C+N EV+ ++ CKDL C+ + K+ + H WD+E + K+++ C Y+ + M+ A I+FCPYNY+L+P IR+SM ++L I++LDEAHNIED RE S ++ SLK + L ++ + +++S E + ++ + E LLS + + + K W + + + + + + + +LA L E RV E I S ++ + M++ + + D+ + + + + V A G + + R+ A L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T +FQDE+G +LL +V+ G+L FL S+ L++ RW+NTGL ++ + K++ EPR + + +E + Y+ +K DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G+ WY IQA+RALNQALGRCIRH+ DWGA+I++D R G+NP Y GL W+++
Sbjct: 243 STKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVYSSVHMTILSSRDHTCVNPEVVPHFNRNERCKDLLEAKNGKSCRFYHGVQKMRDH-HTLQRVHGLHEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDLAGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQHEPLRDFCYALINWIQECQVLLSERGY----ESASKVWSGKDILGIFYGLGITADTFRILKQNLAAVLEKEERVGLVHGKEDMVQVPTISSMTSTVLKNLFMVLDFLYRDNCRFAEDYKVALQRSYSWTNQVPPDVPDAQGFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCK--SRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRY-GNNPNKYITGLSKWVRQ 886 HSP 2 Score: 73.559 bits (179), Expect = 6.033e-13 Identity = 30/63 (47.62%), Postives = 44/63 (69.84%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
++ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCSTL W +
Sbjct: 3 SSAVEYTIGGVKIHFPCKAYPSQLSMMNSIVRGLNYGQHCLLESPTGSGKSLALLCSTLAWQR 65
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242]) HSP 1 Score: 403.29 bits (1035), Expect = 5.691e-123 Identity = 233/652 (35.74%), Postives = 356/652 (54.60%), Query Frame = 1
Query: 295 SRNDECKENAKQ-----VKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHP-------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSI---SLKDI-DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKV--ASGEWISCKKRK---ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTS--EMNECIDAYFKHVK-----DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPT-YSGGLCGWIQK 2124
S D KE AK KIFFGTRTHKQI Q+ ELK++ YS+ M+ILS R+ +C+N EV+ ++ CKDL C+ + K+ + H WD+E + K+++ C Y+ + M+ A I+FCPYNY+L+P IR+SM ++L I++LDEAHNIED RE S ++ SLK + L ++ + +++S E + ++ + E LLS + + + K W + + + + + + + +LA L E RV E I S ++ + M++ + + D+ + + + + V A G + + R+ A L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T +FQDE+G +LL +V+ G+L FL S+ L++ RW+NTGL ++ + K++ EPR + + +E + Y+ +K DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G+ WY IQA+RALNQALGRCIRH+ DWGA+I++D R G+NP Y GL W+++
Sbjct: 243 STKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVYSSVHMTILSSRDHTCVNPEVVPHFNRNERCKDLLEAKNGKSCRFYHGVQKMRDH-HTLQRVHGLHEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDLAGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQHEPLRDFCYALINWIQECQVLLSERGY----ESASKVWSGKDILGIFYGLGITADTFRILKQNLAAVLEKEERVGLVHGKEDMVQVPTISSMTSTVLKNLFMVLDFLYRDNCRFAEDYKVALQRSYSWTNQVPPDVPDAQGFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCK--SRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRY-GNNPNKYITGLSKWVRQ 886 HSP 2 Score: 73.559 bits (179), Expect = 6.285e-13 Identity = 30/63 (47.62%), Postives = 44/63 (69.84%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
++ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCSTL W +
Sbjct: 3 SSAVEYTIGGVKIHFPCKAYPSQLSMMNSIVRGLNYGQHCLLESPTGSGKSLALLCSTLAWQR 65
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242]) HSP 1 Score: 402.905 bits (1034), Expect = 5.705e-123 Identity = 233/652 (35.74%), Postives = 356/652 (54.60%), Query Frame = 1
Query: 295 SRNDECKENAKQ-----VKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHP-------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSI---SLKDI-DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKV--ASGEWISCKKRK---ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTS--EMNECIDAYFKHVK-----DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPT-YSGGLCGWIQK 2124
S D KE AK KIFFGTRTHKQI Q+ ELK++ YS+ M+ILS R+ +C+N EV+ ++ CKDL C+ + K+ + H WD+E + K+++ C Y+ + M+ A I+FCPYNY+L+P IR+SM ++L I++LDEAHNIED RE S ++ SLK + L ++ + +++S E + ++ + E LLS + + + K W + + + + + + + +LA L E RV E I S ++ + M++ + + D+ + + + + V A G + + R+ A L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T +FQDE+G +LL +V+ G+L FL S+ L++ RW+NTGL ++ + K++ EPR + + +E + Y+ +K DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G+ WY IQA+RALNQALGRCIRH+ DWGA+I++D R G+NP Y GL W+++
Sbjct: 243 STKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVYSSVHMTILSSRDHTCVNPEVVPHFNRNERCKDLLEAKNGKSCRFYHGVQKMRDH-HTLQRVHGLHEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDLAGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQHEPLRDFCYALINWIQECQVLLSERGY----ESASKVWSGKDILGIFYGLGITADTFRILKQNLAAVLEKEERVGLVHGKEDMVQVPTISSMTSTVLKNLFMVLDFLYRDNCRFAEDYKVALQRSYSWTNQVPPDVPDAQGFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCK--SRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRY-GNNPNKYITGLSKWVRQ 886 HSP 2 Score: 73.559 bits (179), Expect = 6.454e-13 Identity = 30/63 (47.62%), Postives = 44/63 (69.84%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
++ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCSTL W +
Sbjct: 3 SSAVEYTIGGVKIHFPCKAYPSQLSMMNSIVRGLNYGQHCLLESPTGSGKSLALLCSTLAWQR 65
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242]) HSP 1 Score: 403.29 bits (1035), Expect = 6.119e-123 Identity = 233/652 (35.74%), Postives = 356/652 (54.60%), Query Frame = 1
Query: 295 SRNDECKENAKQ-----VKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHP-------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSI---SLKDI-DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKV--ASGEWISCKKRK---ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTS--EMNECIDAYFKHVK-----DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPT-YSGGLCGWIQK 2124
S D KE AK KIFFGTRTHKQI Q+ ELK++ YS+ M+ILS R+ +C+N EV+ ++ CKDL C+ + K+ + H WD+E + K+++ C Y+ + M+ A I+FCPYNY+L+P IR+SM ++L I++LDEAHNIED RE S ++ SLK + L ++ + +++S E + ++ + E LLS + + + K W + + + + + + + +LA L E RV E I S ++ + M++ + + D+ + + + + V A G + + R+ A L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T +FQDE+G +LL +V+ G+L FL S+ L++ RW+NTGL ++ + K++ EPR + + +E + Y+ +K DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G+ WY IQA+RALNQALGRCIRH+ DWGA+I++D R G+NP Y GL W+++
Sbjct: 243 STKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVYSSVHMTILSSRDHTCVNPEVVPHFNRNERCKDLLEAKNGKSCRFYHGVQKMRDH-HTLQRVHGLHEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDLAGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQHEPLRDFCYALINWIQECQVLLSERGY----ESASKVWSGKDILGIFYGLGITADTFRILKQNLAAVLEKEERVGLVHGKEDMVQVPTISSMTSTVLKNLFMVLDFLYRDNCRFAEDYKVALQRSYSWTNQVPPDVPDAQGFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCK--SRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRY-GNNPNKYITGLSKWVRQ 886 HSP 2 Score: 73.559 bits (179), Expect = 6.954e-13 Identity = 30/63 (47.62%), Postives = 44/63 (69.84%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
++ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCSTL W +
Sbjct: 3 SSAVEYTIGGVKIHFPCKAYPSQLSMMNSIVRGLNYGQHCLLESPTGSGKSLALLCSTLAWQR 65
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Match: brip1 (BRCA1 interacting protein C-terminal helicase 1 [Source:NCBI gene;Acc:101173242]) HSP 1 Score: 402.905 bits (1034), Expect = 7.402e-123 Identity = 233/652 (35.74%), Postives = 356/652 (54.60%), Query Frame = 1
Query: 295 SRNDECKENAKQ-----VKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDL--------CKKMGCIYKIDNQPHP-------ETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSI---SLKDI-DYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAK-LRNEIRVN----GEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKV--ASGEWISCKKRK---ADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTS--EMNECIDAYFKHVK-----DGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPT-YSGGLCGWIQK 2124
S D KE AK KIFFGTRTHKQI Q+ ELK++ YS+ M+ILS R+ +C+N EV+ ++ CKDL C+ + K+ + H WD+E + K+++ C Y+ + M+ A I+FCPYNY+L+P IR+SM ++L I++LDEAHNIED RE S ++ SLK + L ++ + +++S E + ++ + E LLS + + + K W + + + + + + + +LA L E RV E I S ++ + M++ + + D+ + + + + V A G + + R+ A L+ WC+NP + F +S RSI+LTSGTLSP+ SF EL KFS +A HV+ + ++ ++G GP G + A F T +FQDE+G +LL +V+ G+L FL S+ L++ RW+NTGL ++ + K++ EPR + + +E + Y+ +K DGALL+AV RGK SEG+DF D+ AR V+T+GIP+P+I D +V LKM YN K LL G+ WY IQA+RALNQALGRCIRH+ DWGA+I++D R G+NP Y GL W+++
Sbjct: 243 STKDTVKEKAKDDKKRIPKIFFGTRTHKQITQIAHELKRTVYSSVHMTILSSRDHTCVNPEVVPHFNRNERCKDLLEAKNGKSCRFYHGVQKMRDH-HTLQRVHGLHEAWDVEDLVTVAKRLRSCSYYAARELMQGASIIFCPYNYLLDPMIRESMEIDLAGQILVLDEAHNIEDCARESTSFTLDESSLKTCREELDSMVKNNIRRSQHEPLRDFCYALINWIQECQVLLSERGY----ESASKVWSGKDILGIFYGLGITADTFRILKQNLAAVLEKEERVGLVHGKEDMVQVPTISSMTSTVLKNLFMVLDFLYRDNCRFAEDYKVALQRSYSWTNQVPPDVPDAQGFLVRPRPRRRQTARVKTEILTLSFWCLNPAVAFSDLSGSVRSIVLTSGTLSPMGSFSSELGVKFSIQLEANHVINKSQVWVGTVGAGPQGKKLCATFQHTETYAFQDEVGDLLLHICKVIAKGVLCFLPSYKLLDKLRDRWSNTGLWEKLEQQKTVITEPRGGAKGDFDELLQTYYDAIKCCDERDGALLIAVCRGKVSEGLDFTDDNARAVVTIGIPFPNIKDLQVELKMKYNDQHCK--SRGLLPGHRWYEIQAYRALNQALGRCIRHKNDWGALILVDDRY-GNNPNKYITGLSKWVRQ 886 HSP 2 Score: 73.559 bits (179), Expect = 6.486e-13 Identity = 30/63 (47.62%), Postives = 44/63 (69.84%), Query Frame = 1
Query: 79 TNMVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLK 267
++ VE+ + V + FP + YP QL MM I+ +N ++CL+E PTGSGK++ALLCSTL W +
Sbjct: 3 SSAVEYTIGGVKIHFPCKAYPSQLSMMNSIVRGLNYGQHCLLESPTGSGKSLALLCSTLAWQR 65
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Match: SMESG000018012.1 (SMESG000018012.1) HSP 1 Score: 1469.14 bits (3802), Expect = 0.000e+0 Identity = 711/713 (99.72%), Postives = 711/713 (99.72%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 2223
MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVN EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKAD LNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID
Sbjct: 1 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKMGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNEEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADVLNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 713
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Match: SMESG000018012.1 (SMESG000018012.1) HSP 1 Score: 1176.77 bits (3043), Expect = 0.000e+0 Identity = 568/570 (99.65%), Postives = 568/570 (99.65%), Query Frame = 1
Query: 514 MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 2223
MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVN EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKAD LNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID
Sbjct: 1 MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNEEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADVLNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 570
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Match: SMESG000018012.1 (SMESG000018012.1) HSP 1 Score: 1100.12 bits (2844), Expect = 0.000e+0 Identity = 539/570 (94.56%), Postives = 539/570 (94.56%), Query Frame = 1
Query: 514 MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 2223
MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVN EITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKAD LNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPK AFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID
Sbjct: 1 MGCIYKIDNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNEEITDSTSEIPSSFMQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADVLNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPK-----------------------------AFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFIDLHCQVDIDKLPID 541
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Match: SMESG000032754.1 (SMESG000032754.1) HSP 1 Score: 673.315 bits (1736), Expect = 0.000e+0 Identity = 353/781 (45.20%), Postives = 479/781 (61.33%), Query Frame = 1
Query: 85 MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGWLKQYQSQLLLNSRNDECKENAKQVKIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQNCKDLCKKM---GCIYKI-------DNQPHPETTWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDIDYLKMLLPHILKKSGKEDCQHDLLTMLEKMHEVIELLSSKLFYKDEDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRV--------------------NGEITDS------------------------------------TSEIPSSF------MQLIDSFIMLVKLMMDSDKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDISRSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKDGALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHF---------DDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQKRKIDFRNCEDLYVSLQLFID 2184
MV +S VPV FP EPY QL+MM RIINS+ K +NCL+ELPTGSGKT+ LLCSTL W L ++ E KIF+GTRTHKQI QV+REL K+AY N RM+ILSGRN SCLN+EV +I+++C+D+C+ + C Y+ + TWD+ SI KL+++ CPY+Q K W+ SADIVFCPYNYILNPFIR+ + V+L+ ++ILDEAHNIEDICRE S+++S +I+ + L I+ + L+ ML + +I+ LS K F E+VLKK W+ F+++LK +L +ENI ++ L +L N +R NGE + T E P F + L+++ +M+ +L+ D + +DFS+V+TE W L VLN+WCMNPGI FK I+D SIILTSGTL+P SF+KEL C F ++F+A HVV ++TF+AS+ GP+ ++AVFS F+DELG+++L+CS+VVPNG+L FLSSFAL++ +QR +TGL+N+IR+HK + EP+ + EM C+ ++ +K GALL AV+RGKASEG+DFADEAARLVITVGIPYPS ADPKVVLK +YN NK+K+ + Q LSG++WY IQAFRALNQA+GRCIRHR DWGAM+M+DSR DG +P+ + GLC WI++RK + + DL+ L FI+
Sbjct: 1 MVINDISGVPVDFPNEPYSSQLFMMHRIINSLIKGQNCLLELPTGSGKTMGLLCSTLAWYTN--GALAVDPATG--TEAGITTKIFYGTRTHKQIQQVVRELSKTAYCNVRMNILSGRNQSCLNEEVKRKPDINKSCRDICRALEDSQCRYRKKKNIKANEKMALSPGTWDLTSIKDKLQRIDCCPYYQMKCWLPSADIVFCPYNYILNPFIRRVLKVDLKRAVVILDEAHNIEDICRESTSLAVSSTEIELCLIQLHLIVNHGAQNGFLKQLIKMLVAVQALIKSLSVKTFATGEEVLKKCWNPLRFIEILKEKELAMENIIEYQGCLEQLNNFLRTSHSQAELEDIEDFRMIPETDNGEEEEDECDHQADRGDYNNCYHGDDMDVYMEAQSTADKKPKKTMESPKYFSMSAESLNLMETLLMICRLIQDEKRNCSDDFSVVVTEC---------------WHKASMDTESKLE--LVLNLWCMNPGIAFKDIADNCHSIILTSGTLNPTASFQKELQCCFQSVFEAPHVVSADRTFMASLSRGPTNKEIQAVFSNIETFEFKDELGRLILECSKVVPNGVLCFLSSFALMDGLLQRLEDTGLMNQIRQHKFVTKEPKSSMEMENCMAKFYSKIKTGALLFAVYRGKASEGIDFADEAARLVITVGIPYPSAADPKVVLKRHYNDNKRKNLGTNEAAAGENQQGLSGHQWYKIQAFRALNQAIGRCIRHRSDWGAMLMVDSRFDGFDPSNTNGLCKWIKRRKNHYEDFNDLFYYLVRFIE 760
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Match: SMESG000064419.1 (SMESG000064419.1) HSP 1 Score: 326.25 bits (835), Expect = 1.670e-97 Identity = 220/736 (29.89%), Postives = 371/736 (50.41%), Query Frame = 1
Query: 109 VPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIALLCSTLGW---LKQYQSQ------LLLNSRNDECKENAKQV-----------KIFFGTRTHKQIGQVIRELKKSAYSNTRMSILSGRNLSCLNQEVLMSKEIDQN------CKDLCKKMGCIY-----KIDNQPHPET-TWDIESISMKLKKVKICPYFQFKSWMKSADIVFCPYNYILNPFIRKSMGVNLENNIIILDEAHNIEDICREGASMSISLKDI----DYLKML---------LPHILKKSGKEDCQHDL--LTMLEKMHEVIELLSSKLFYKD---EDVLKKTWDLESFVQLLKNCQLDLENIKNFENHLAKLRNEIRVNGEITDSTSEIPS-----SFMQLIDSFIMLVKLMMDS----DKTKQNDFSIVITEGEKYAEPINEKVASGEWISCKKRKADALNNNFVLNIWCMNPGIVFKQISDIS-RSIILTSGTLSPVVSFEKELNCKFSAIFQAGHVVQPEKTFLASIGNGPSGNAMKAVFSTTSKLSFQDELGQMLLKCSEVVPNGILIFLSSFALIELFMQRWTNTGLINEIRKHKSIFIEPRQTSEMNECIDAYFKHVKD-----GALLLAVFRGKASEGVDFADEAARLVITVGIPYPSIADPKVVLKMNYNTNKKKHFDDQLLSGNEWYNIQAFRALNQALGRCIRHREDWGAMIMIDSRLDGSNPTYSGGLCGWIQ 2121
V + FP EPY Q+ M ++I S+ +N ++E PTG+GKT+ LLC+ L W +K+ + L LNS ++ K+ KI + +RTH Q+ Q I LK++ Y + ++ +++ R C+N +V+ ++ N CK K C + K ET DIE + KK +CPYF + SADI F PYNY+L+ IR+ +NL+ NI+I DEAHNIE +C + AS+ ++ +I + LK+L I+ ++ E ++ LT + + + + +L S+ D T ++ QLL C + N +F + L K + I ++ E T + I FM+ + F + DS +K + + I E E N K+ W S K + + + N VL+ WCM G K ++ RSIILTSGTL P+ + + +++ KF + HV+ ++ ++ G G + + + T K+S+ + LG +L S+++P G+L+ S+ ++ ++RW + + N + +HK + +EP+ ++ ++ ++ D G++LL+V RGK SEG+D +D R VI VG+PYPS+ DP++ LKM++ ++ K F + G WY QA+RA+NQ++GR IRH D+GA+ + D R ++ + L W+Q
Sbjct: 9 VSIDFPFEPYACQIIYMEKVIESLKDGKNAILESPTGTGKTLCLLCAALAWQDHVKKVTTNSEDEILLHLNSNGNQYWNKVKKSQLNISKINVVPKIIYSSRTHSQLSQCINALKRTQYCDRKVGMIASREQLCINPKVM---NLESNTAKIYGCKSRVKTRKCFFYNQFEKAKEILSSETKIADIEDLLTIGKKKSVCPYFLSREMFDSADITFMPYNYLLDSKIRRLYNINLKGNIVIFDEAHNIEQVCEDSASVQLTSINIASCIEELKVLGEFIYSIQSTDAIIDEADNESRSDEIPDLTQIIHLKQNLCILESEFHSIDLGNNANAGLTVEVNILFQLLNRCGFNHSNKLHFIDLLEKCSSFIGMSSEPTLTKHGIKGLEKVQEFMKTV--FFDEIGEEFDSIDNLEKKLSACYRVFIQENEIATSNRNNKI---NWGSNKNQAVNG-DKNRVLSFWCMTAGRTMKSLAGCEVRSIILTSGTLYPIETLKLDMDIKFEVELRNSHVINADQMMVSVCTKGADGEPLNSSYLTREKISYTNSLGNSILNLSKIIPRGLLVVFPSYGMMRKCIERWESCDIYNSMMQHKQLIVEPQDKTKFTLAMEQFYSKNSDPLSNKGSILLSVARGKISEGLDLSDHQGRGVIVVGLPYPSMMDPRIRLKMSFLDDRLKLFKFG-IDGRCWYKQQAYRAVNQSIGRVIRHSRDFGAIYLFDERFATADSRFQLPL--WLQ 732 The following BLAST results are available for this feature:
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 4
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 2
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 2
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Regulator of telomere elongation helicase 1 homolog vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30018649 ID=SMED30018649|Name=Regulator of telomere elongation helicase 1 homolog|organism=Schmidtea mediterranea sexual|type=transcript|length=2327bpback to top protein sequence of SMED30018649-orf-1 >SMED30018649-orf-1 ID=SMED30018649-orf-1|Name=SMED30018649-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=714bp MVEFKLSDVPVTFPIEPYPQQLYMMRRIINSINKSENCLMELPTGSGKTIback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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