Protein FAM192A

Overview
NameProtein FAM192A
Smed IDSMED30018544
Length (bp)847
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Protein FAM192A (SMED30018544) t-SNE clustered cells

Violin plots show distribution of expression levels for Protein FAM192A (SMED30018544) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Protein FAM192A (SMED30018544) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Protein FAM192A (SMED30018544) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30018544

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 1

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30018544SMESG000016251.1 SmedASXL_001389SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Protein FAM192A vs. Ensembl Human
Match: PSME3IP1 (proteasome activator subunit 3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29856])

HSP 1 Score: 48.1358 bits (113), Expect = 8.963e-7
Identity = 26/56 (46.43%), Postives = 39/56 (69.64%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            Y  +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV +   L EK++
Sbjct:   49 YDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEKQR 104
[Close]
BLAST of Protein FAM192A vs. Ensembl Human
Match: PSME3IP1 (proteasome activator subunit 3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29856])

HSP 1 Score: 47.7506 bits (112), Expect = 1.833e-6
Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            Y  +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   49 YDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Human
Match: PSME3IP1 (proteasome activator subunit 3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29856])

HSP 1 Score: 47.7506 bits (112), Expect = 2.049e-6
Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            Y  +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   49 YDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Human
Match: PSME3IP1 (proteasome activator subunit 3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29856])

HSP 1 Score: 47.7506 bits (112), Expect = 2.531e-6
Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            Y  +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   49 YDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Human
Match: PSME3IP1 (proteasome activator subunit 3 interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:29856])

HSP 1 Score: 48.1358 bits (113), Expect = 2.893e-6
Identity = 26/52 (50.00%), Postives = 37/52 (71.15%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            Y  +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   49 YDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Zebrafish
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6692])

HSP 1 Score: 47.7506 bits (112), Expect = 3.817e-6
Identity = 25/53 (47.17%), Postives = 38/53 (71.70%), Query Frame = 3 
Query:  216 KSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            +SL+E+LQEQK+ K +++EE+  FKN VK  DED+ +F+ EV +   L EK +
Sbjct:   45 RSLFERLQEQKDKKQEEYEEQFKFKNMVKGLDEDETSFLDEVSRKQSLIEKHR 97
[Close]
BLAST of Protein FAM192A vs. Ensembl Zebrafish
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-6692])

HSP 1 Score: 47.7506 bits (112), Expect = 3.817e-6
Identity = 25/53 (47.17%), Postives = 38/53 (71.70%), Query Frame = 3 
Query:  216 KSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            +SL+E+LQEQK+ K +++EE+  FKN VK  DED+ +F+ EV +   L EK +
Sbjct:   45 RSLFERLQEQKDKKQEEYEEQFKFKNMVKGLDEDETSFLDEVSRKQSLIEKHR 97
[Close]
BLAST of Protein FAM192A vs. Ensembl Mouse
Match: Fam192a (family with sequence similarity 192, member A [Source:MGI Symbol;Acc:MGI:1919637])

HSP 1 Score: 55.0694 bits (131), Expect = 2.566e-9
Identity = 32/72 (44.44%), Postives = 46/72 (63.89%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV +   L EK++
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEKQR 104
[Close]
BLAST of Protein FAM192A vs. Ensembl Mouse
Match: Fam192a (family with sequence similarity 192, member A [Source:MGI Symbol;Acc:MGI:1919637])

HSP 1 Score: 54.299 bits (129), Expect = 3.962e-9
Identity = 32/68 (47.06%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Mouse
Match: Fam192a (family with sequence similarity 192, member A [Source:MGI Symbol;Acc:MGI:1919637])

HSP 1 Score: 54.6842 bits (130), Expect = 4.447e-9
Identity = 32/68 (47.06%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Mouse
Match: Fam192a (family with sequence similarity 192, member A [Source:MGI Symbol;Acc:MGI:1919637])

HSP 1 Score: 54.6842 bits (130), Expect = 5.701e-9
Identity = 32/68 (47.06%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Mouse
Match: Fam192a (family with sequence similarity 192, member A [Source:MGI Symbol;Acc:MGI:1919637])

HSP 1 Score: 55.0694 bits (131), Expect = 8.373e-9
Identity = 32/68 (47.06%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. UniProt/SwissProt
Match: sp|Q91WE2|PIP30_MOUSE (PSME3-interacting protein OS=Mus musculus OX=10090 GN=Psme3ip1 PE=1 SV=1)

HSP 1 Score: 54.6842 bits (130), Expect = 1.874e-7
Identity = 32/68 (47.06%), Postives = 44/68 (64.71%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLL 359
            PK  PE +YDP        +SLYE+LQEQK+ K +++EE+  FKN V+  DED+  F+ EV RQ  L+
Sbjct:   41 PKECPEEAYDP--------RSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELI 100
[Close]
BLAST of Protein FAM192A vs. TrEMBL
Match: V8NTW7 (Nefa_Nip30_N domain-containing protein (Fragment) OS=Ophiophagus hannah OX=8665 GN=L345_08505 PE=4 SV=1)

HSP 1 Score: 62.3882 bits (150), Expect = 2.137e-7
Identity = 57/176 (32.39%), Postives = 92/176 (52.27%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDA 683
            PK  PE  YDP        +SLYE+LQEQK+ K ++FEE+  FKN V+  DED+  F+ EV RQ TL+ EK++  E    +   +   A ++    ++ ++ D+KL+   ++  +  +  LL   +K + ++ +  +  K LKLD D +     +  IP+ AS    P G   M  
Sbjct:   91 PKECPEEVYDP--------RSLYERLQEQKDKKQQEFEEQFKFKNMVRGLDEDESKFLDEVSRQQTLI-EKQRHEEDLKELNEYRISLALKIGASADLKKEADKKLSVKSENKSKFSQAKLLAGAVKHRSSEGANSV--KRLKLDPDPD-----HDKIPEKAS--CVPLGGSAMSG 248
[Close]
BLAST of Protein FAM192A vs. TrEMBL
Match: A0A098LYV2 (Protein FAM192A-like isoform 1 OS=Hypsiglena sp. JMG-2014 OX=1550645 PE=4 SV=1)

HSP 1 Score: 60.077 bits (144), Expect = 7.237e-7
Identity = 51/188 (27.13%), Postives = 95/188 (50.53%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEI------------AIANQSIPQPASEQIEPAGVPGMDAY 686
            PK  PE  YDP        +SLYE+LQEQK+ K ++FEE+  FKN V+  DED+  F+ EV +  +L EK++ +E         +   +++    ++ ++ D+KL+   ++  +  +  LL   +K + ++ +  ++   L  D D ++I            A++  ++  P S  +    +PG+ AY
Sbjct:   42 PKECPEEVYDP--------RSLYERLQEQKDKKQQEFEEQFKFKNMVRGLDEDESKFLDEVSRQQVLIEKQR-HEEDLKELNEYRNTLSKVGASADLKKEADKKLSVKSENKSKFSQAKLLAGAVKHRSSEGANSVKRLKLDPDPDHDKIPEKPPCVPLGSSAMSGSALHCP-SAAVCIGILPGLGAY 219
[Close]
BLAST of Protein FAM192A vs. TrEMBL
Match: A0A2D4P604 (Nefa_Nip30_N domain-containing protein (Fragment) OS=Micrurus surinamensis OX=129470 PE=4 SV=1)

HSP 1 Score: 59.6918 bits (143), Expect = 1.364e-6
Identity = 56/178 (31.46%), Postives = 92/178 (51.69%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEV-RQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDAYA 689
            PK  PE  YDP        +SLYE+LQEQK+ K ++FEE+  FKN V+  DED+  F+ EV RQ TL+ EK++ +E         +   +++    ++ ++ D+KL    ++  +  +  LL   +K + ++ +  +  K LKLD D +     +  +P+ AS    P G   M   A
Sbjct:   63 PKECPEEVYDP--------RSLYERLQEQKDKKQQEFEEQFKFKNMVRGLDEDESKFLDEVSRQQTLI-EKQR-HEEDLKELNEYRNTLSKVGASADLKKEADKKLLVKSENKSKFSQAKLLAGAVKHRSSEGANSV--KRLKLDPDPD-----HDKVPEKAS--CVPLGSSAMSGSA 221
[Close]
BLAST of Protein FAM192A vs. TrEMBL
Match: U3F8B4 (FAM192A OS=Micrurus fulvius OX=8637 PE=2 SV=1)

HSP 1 Score: 58.9214 bits (141), Expect = 1.855e-6
Identity = 53/177 (29.94%), Postives = 89/177 (50.28%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDAYA 689
            PK  PE  YDP        +SLYE+LQEQK+ K ++FEE+  FKN V+  DED+  F+ EV +   L EK++ +E         +   +++    ++ ++ D+KL    ++  +  +  LL   +K + ++ +  +  K LKLD D +     +  +P+ AS    P G   M   A
Sbjct:   42 PKECPEEVYDP--------RSLYERLQEQKDKKQQEFEEQFKFKNMVRGLDEDESKFLDEVSRQQALIEKQR-HEEDLKELNEYRNTLSKVGASADLKKEADKKLLVKSENKSKFSQAKLLAGAVKHRSSEGANSV--KRLKLDPDPD-----HDKVPEKAS--CVPLGSSAMSGSA 200
[Close]
BLAST of Protein FAM192A vs. TrEMBL
Match: A0A1W7RFB0 (NEFA-interacting nuclear protein NIP30 OS=Agkistrodon contortrix contortrix OX=8713 PE=4 SV=1)

HSP 1 Score: 57.7658 bits (138), Expect = 5.015e-6
Identity = 53/187 (28.34%), Postives = 97/187 (51.87%), Query Frame = 3 
Query:  159 PKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEIAIANQSIPQPASE------QIEPAGV-----PGMDAY 686
            PK  PE  YDP        +SLYE+LQEQK+ K ++FEE+  FKN V+  DED+  F+ EV +  +L EK++ +E +       +   +++    ++ +++D+KL+A  ++  +  +  LL   +K + ++ +  ++   L  D D+++I      +P+ +S           A V     PG+ AY
Sbjct:   42 PKECPEEVYDP--------RSLYERLQEQKDKKQQEFEEQFKFKNMVRGLDEDESKFLDEVSRQQVLIEKQR-HEEELKELNEYRSTLSKVGASADLKKEVDKKLSAKLENKNKFSQAKLLAGAVKHRSSEGANSVKRLKLDPDPDDDKIPEKPSCVPRGSSTMGGATLHCPSAAVCIGILPGLGAY 219
[Close]
BLAST of Protein FAM192A vs. Ensembl Cavefish
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:NCBI gene;Acc:103039296])

HSP 1 Score: 47.3654 bits (111), Expect = 5.002e-6
Identity = 25/53 (47.17%), Postives = 38/53 (71.70%), Query Frame = 3 
Query:  216 KSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            +SL+E+LQEQK+ K +++EE+  FKN VK  DED+  F+ EV +   L EK++
Sbjct:   48 RSLFERLQEQKDKKQEEYEEQFKFKNMVKGLDEDETNFLDEVSRQQSLVEKQR 100
[Close]
BLAST of Protein FAM192A vs. Ensembl Cavefish
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:NCBI gene;Acc:103039296])

HSP 1 Score: 46.9802 bits (110), Expect = 6.689e-6
Identity = 25/53 (47.17%), Postives = 38/53 (71.70%), Query Frame = 3 
Query:  216 KSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            +SL+E+LQEQK+ K +++EE+  FKN VK  DED+  F+ EV +   L EK++
Sbjct:   61 RSLFERLQEQKDKKQEEYEEQFKFKNMVKGLDEDETNFLDEVSRQQSLVEKQR 113
[Close]
BLAST of Protein FAM192A vs. Ensembl Medaka
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:NCBI gene;Acc:101154775])

HSP 1 Score: 52.373 bits (124), Expect = 1.428e-7
Identity = 26/56 (46.43%), Postives = 41/56 (73.21%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            Y S+SL+E+LQEQK+ K ++FEE+  F+N V+  DED+ +F+ EV +   L EK++
Sbjct:   49 YDSRSLFERLQEQKDKKQQEFEEQFKFRNMVRGLDEDESSFLDEVSRQQSLVEKQR 104
[Close]
BLAST of Protein FAM192A vs. Ensembl Medaka
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:NCBI gene;Acc:101154775])

HSP 1 Score: 52.373 bits (124), Expect = 1.428e-7
Identity = 26/56 (46.43%), Postives = 41/56 (73.21%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            Y S+SL+E+LQEQK+ K ++FEE+  F+N V+  DED+ +F+ EV +   L EK++
Sbjct:   49 YDSRSLFERLQEQKDKKQQEFEEQFKFRNMVRGLDEDESSFLDEVSRQQSLVEKQR 104
[Close]
BLAST of Protein FAM192A vs. Ensembl Medaka
Match: psme3ip1 (proteasome activator subunit 3 interacting protein 1 [Source:NCBI gene;Acc:101154775])

HSP 1 Score: 52.373 bits (124), Expect = 1.479e-7
Identity = 26/56 (46.43%), Postives = 41/56 (73.21%), Query Frame = 3 
Query:  207 YCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEK 374
            Y S+SL+E+LQEQK+ K ++FEE+  F+N V+  DED+ +F+ EV +   L EK++
Sbjct:   49 YDSRSLFERLQEQKDKKQQEFEEQFKFRNMVRGLDEDESSFLDEVSRQQSLVEKQR 104
[Close]
BLAST of Protein FAM192A vs. Planmine SMEST
Match: SMESG000016251.1 (SMESG000016251.1)

HSP 1 Score: 352.058 bits (902), Expect = 1.163e-123
Identity = 215/217 (99.08%), Postives = 217/217 (100.00%), Query Frame = 3 
Query:  147 MSNLPKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNAVKIYDEDDLAFMQEVRQSTLLKEKEKANXXXXXXXXXXXXXXXRLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDAYAXXXXXXXXXXXXXXXXXXXIDVGTLRPLIKRLNEKI 797
            MSNLPKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSF+NAVKIYDEDDLAFMQEVRQSTLLKEKEKANEVKALVELAKKKEAARLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIE+KSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDAYASDDHSDSDCSSCCSSSSSDIDVGTLRPLIKRLNEKI
Sbjct:    1 MSNLPKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFENAVKIYDEDDLAFMQEVRQSTLLKEKEKANEVKALVELAKKKEAARLNNPINIYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIESKSLKLDLDENEIAIANQSIPQPASEQIEPAGVPGMDAYASDDHSDSDCSSCCSSSSSDIDVGTLRPLIKRLNEKI 217
The following BLAST results are available for this feature:
BLAST of Protein FAM192A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
PSME3IP18.963e-746.43proteasome activator subunit 3 interacting protein... [more]
PSME3IP11.833e-650.00proteasome activator subunit 3 interacting protein... [more]
PSME3IP12.049e-650.00proteasome activator subunit 3 interacting protein... [more]
PSME3IP12.531e-650.00proteasome activator subunit 3 interacting protein... [more]
PSME3IP12.893e-650.00proteasome activator subunit 3 interacting protein... [more]
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BLAST of Protein FAM192A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
psme3ip13.817e-647.17proteasome activator subunit 3 interacting protein... [more]
psme3ip13.817e-647.17proteasome activator subunit 3 interacting protein... [more]
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BLAST of Protein FAM192A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Fam192a2.566e-944.44family with sequence similarity 192, member A [Sou... [more]
Fam192a3.962e-947.06family with sequence similarity 192, member A [Sou... [more]
Fam192a4.447e-947.06family with sequence similarity 192, member A [Sou... [more]
Fam192a5.701e-947.06family with sequence similarity 192, member A [Sou... [more]
Fam192a8.373e-947.06family with sequence similarity 192, member A [Sou... [more]
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BLAST of Protein FAM192A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 1
Match NameE-valueIdentityDescription
sp|Q91WE2|PIP30_MOUSE1.874e-747.06PSME3-interacting protein OS=Mus musculus OX=10090... [more]
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BLAST of Protein FAM192A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
V8NTW72.137e-732.39Nefa_Nip30_N domain-containing protein (Fragment) ... [more]
A0A098LYV27.237e-727.13Protein FAM192A-like isoform 1 OS=Hypsiglena sp. J... [more]
A0A2D4P6041.364e-631.46Nefa_Nip30_N domain-containing protein (Fragment) ... [more]
U3F8B41.855e-629.94FAM192A OS=Micrurus fulvius OX=8637 PE=2 SV=1[more]
A0A1W7RFB05.015e-628.34NEFA-interacting nuclear protein NIP30 OS=Agkistro... [more]
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BLAST of Protein FAM192A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
psme3ip15.002e-647.17proteasome activator subunit 3 interacting protein... [more]
psme3ip16.689e-647.17proteasome activator subunit 3 interacting protein... [more]
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BLAST of Protein FAM192A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Protein FAM192A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
psme3ip11.428e-746.43proteasome activator subunit 3 interacting protein... [more]
psme3ip11.428e-746.43proteasome activator subunit 3 interacting protein... [more]
psme3ip11.479e-746.43proteasome activator subunit 3 interacting protein... [more]
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BLAST of Protein FAM192A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000016251.11.163e-12399.08SMESG000016251.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018544 ID=SMED30018544|Name=Protein FAM192A|organism=Schmidtea mediterranea sexual|type=transcript|length=847bp
AAATATTTTGACTTTTAAAGTGTAAAATTGCAATATTTATAAGATTTGTG
TTGTAGTTAAAAAATTTGTTTAATTAATCATATTTAAAAATTAAAAAATA
TTTTTACGAATTTATTTAATTTAACTTATTGATTAAAATATTAACTATGT
CCAATTTACCTAAATTTACACCCGAGGGCTCATACGATCCTAATGAAAAC
AAAGAATATTGTTCAAAATCGTTATATGAACAACTTCAAGAGCAAAAAAA
TATCAAACTAAAGAAATTTGAAGAAGAAACATCATTTAAAAACGCCGTCA
AAATATATGATGAAGACGATTTGGCATTCATGCAAGAAGTTCGTCAGTCA
ACATTATTAAAAGAAAAAGAAAAAGCCAATGAAGTAAAAGCTTTGGTAGA
ATTAGCAAAAAAAAAAGAAGCAGCAAGATTAAATAATCCAATAAATATAT
ACGAAAAACTCGATGAAAAGTTGACAGCAATGCGAAAATCAACTGAAGAA
AGCGATAAAATGAATTTGTTAAAATCGATGATGAAACGAAAACGAGCTAA
AGATTCCTGCGAAATCGAAAACAAATCTTTGAAGCTGGATTTAGATGAGA
ATGAAATTGCTATTGCAAATCAATCAATACCGCAACCGGCGAGCGAACAA
ATCGAACCGGCCGGCGTTCCTGGGATGGACGCGTATGCCAGTGATGATCA
CAGCGATTCTGACTGCTCCAGTTGCTGCTCCTCCTCATCATCAGATATCG
ATGTCGGCACCCTCCGGCCGCTCATCAAGCGGTTGAATGAGAAAATCAAG
AAAAATTGCTGATTTTAATTTGTGAATAAATTTGGCAGATCGGAAGA
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protein sequence of SMED30018544-orf-1

>SMED30018544-orf-1 ID=SMED30018544-orf-1|Name=SMED30018544-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=222bp
MSNLPKFTPEGSYDPNENKEYCSKSLYEQLQEQKNIKLKKFEEETSFKNA
VKIYDEDDLAFMQEVRQSTLLKEKEKANEVKALVELAKKKEAARLNNPIN
IYEKLDEKLTAMRKSTEESDKMNLLKSMMKRKRAKDSCEIENKSLKLDLD
ENEIAIANQSIPQPASEQIEPAGVPGMDAYASDDHSDSDCSSCCSSSSSD
IDVGTLRPLIKRLNEKIKKNC*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0002109X1 cell
Vocabulary: INTERPRO
TermDefinition
IPR039845FAM192A
IPR019331FAM192A/Fyv6_N
Vocabulary: molecular function
TermDefinition
GO:0005515protein binding
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
NoneNo IPR availableCOILSCoilCoilcoord: 70..90
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 158..184
IPR019331FAM192A/Fyv6, N-terminalPFAMPF10187Nefa_Nip30_Ncoord: 17..82
e-value: 8.8E-12
score: 45.3
IPR039845PSME3-interacting proteinPANTHERPTHR13495NEFA-INTERACTING NUCLEAR PROTEIN NIP30coord: 15..190