Guanylate cyclase

Overview


Name	Guanylate cyclase
Smed ID	SMED30018527
Length (bp)	3664

Neoblast Clusters

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

Overview

Single cell RNA-seq of pluripotent neoblasts and its early progenies

We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)

Explore this single cell expression dataset with our NB Cluster Shiny App

Neoblast Population

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.

Expression of Guanylate cyclase (SMED30018527) t-SNE clustered cells

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30018527) in cells (dots) of each of the 12 neoblast clusters.

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Guanylate cyclase (SMED30018527) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Guanylate cyclase (SMED30018527) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

Anatomical Expression

PAGE et. al., 2020

SMED30018527

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE

PAGE Curations: 13

Expressed In	Reference Transcript	Gene Models	Published Transcript	Transcriptome	Publication
head region	SMED30018527	h1SMcG0020489	SmedASXL_015882	SmedAsxl_ww_GCZZ01	PMID:27034770 Currie et al., 2016
protonephridia	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
nervous system	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
epidermis	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
cephalic ganglia	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
muscle cell	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
neoblast	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
parenchyma	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
non-ciliated neuron	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30018527	h1SMcG0020489	Contig48972	uc_Smed_v2	PMID:29674431 Fincher et al., 2018
Smed sexual biotype	SMED30018527	h1SMcG0020489	Contig48972	newmark_ests	PMID:29674431 Fincher et al., 2018
body wall musculature	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:30471994 Scimone et al., 2018
dorsal ventral margin of the whole animal	SMED30018527	h1SMcG0020489	dd_Smed_v4_7644_0_1	dd_Smed_v4	PMID:28292427 Wurtzel et al., 2017

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Homology

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 610.527 bits (1573), Expect = 0.000e+0
Identity = 303/516 (58.72%), Postives = 389/516 (75.39%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            Q+F KTA YKGN+VA+K + +++RI++ R++L ++K ++D+ N+H+ RF+GAC +     ++ +YCP+GSL+D+L  E ITLDW+F+YSL  DI +GM++LHN  G I   G LKSSNC+VD RFVLKITD+GL S R     L  E  +  +   LWTAPELLRM++PP+ G+  GDVYSF I+ QEI  R GVF ++  D  S +EI+E V     P PFRPSL A+    E+  LL+++ W EDP  RP F  I+  +RKFN+E +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LHA E+ARMA+A L A+  F I HRP ++L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S  T  +L+ FG F +  RG +E+KGKG  +TYWL GE 
Sbjct:  551 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHN--GAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD----LDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQP-PFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGER 1055

HSP 2 Score: 220.705 bits (561), Expect = 3.641e-58
Identity = 146/508 (28.74%), Postives = 242/508 (47.64%), Query Frame = 3

Query:  270 LMLPKNFSMFPWPLTI--PAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYC----HALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSS------GNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNL 1748
            ++LP   + +PW      PA+++AL +VK+ P + P   +   L + E    +C +T   L   V       P V  GP C Y  AP+ R  A W +P+L+ GA   GF    K E+   TR G  +  L  G  +    ++  W     + +  AY      +C      L   +     ITVD+    ++ E   +  T        L+  +  K  V  +C  P +   ++L A +      +YVF ++ +F        G   + PW        ++  A++A+++   +T K P+N ++  F  Q+K +A  ++N+  E  L+NT  ++F+DG+LLY  A+ +TLA GG +++G  I + MWN +F+G+ G + IDSSGDR  DFS+ DMDP+ G F+ V ++ GT    + V    ++W       P   P+CG+DN        +L+   + A V     L      +F+YR ++L+ EL +  W + WE +E S   R+L
Sbjct:   39 VVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLA-AVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGV--KDEYALTTRAGPSYAKL--GDFVAALHRRLGWERQALMLY--AYRPGDEEHCFFLVEGLFMRVRDRLNITVDHL---EFAEDDLSHYTR-------LLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW---ERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHL 524

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: NPR2 (natriuretic peptide receptor 2 [Source:HGNC Symbol;Acc:HGNC:7944])

HSP 1 Score: 588.956 bits (1517), Expect = 0.000e+0
Identity = 293/515 (56.89%), Postives = 379/515 (73.59%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSF I+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T   L   G F +  RG +E+KGKG  +TYWL GE +
Sbjct:  535 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFGIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERK 1041

HSP 2 Score: 185.267 bits (469), Expect = 5.934e-47
Identity = 140/502 (27.89%), Postives = 230/502 (45.82%), Query Frame = 3

Query:  261 LAMLMLPKNFS-MFPWPLTIPAIKIALEKV-KSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY-LTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKR-AYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPK-PDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            LA+++   N S  + WP   PA+ +A+E + +++P     V S      ++  C E   A    V   +   PD+L GP C Y  A +AR  + W +P+L+ GAV  GF   +   ++TL R G     L  G+ +      + WT    + +  A T+  P Y    G +   Q   ++V +           A            I A G    +  +C     +H ILL+A + N  NG+YVF  + +F           T  PW    +   E ++A R A++++L +T + P N +++ F +++   A  ++       L+N     FYDG+LLYA  LN+T+ +GG   +G  I++ M    + G+ G V +D + DR  DF +  M D  +G+F+P AH+ G +          + W  V    PS  P C +  D+  C K P   L I A+  G+   +F +S    + ++R + L+ EL +M W I WE L+
Sbjct:   27 LAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSS-----ELEGACSEY-LAPLSAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF-SAKNDHYRTLVRTGPSAPKL--GEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH--------QVYAREPGGPEQATHFIRANGR---IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPW--QDNRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELGPSLMNLIAGCFYDGILLYAEVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWT-GRPIPW--VKGAPPSDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVS---SFLIFRKLMLEKELASMLWRIRWEELQ 500

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2F (guanylate cyclase 2F, retinal [Source:HGNC Symbol;Acc:HGNC:4691])

HSP 1 Score: 432.565 bits (1111), Expect = 1.257e-131
Identity = 230/485 (47.42%), Postives = 317/485 (65.36%), Query Frame = 3

Query: 2127 VKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTE-RGHIEVKGKGSTQTYWLHGENELIVDPIP 3578
            +KDL +++I   +G   + G   +V ++C +GSLED+L  + + LDW+FK SL+ D+ +GM YLH+     G LKS NC+VD RFVLK+TD+G   +    + L   +     + LLWTAPELLR       G+F GDVYSFAI+ QE++ R   F +    D  AQEI+  +K           +        + + L+KQ W E    RP F+ I    + FNK G   NI+D++L  +EQY++NLED+++ERTE+   EK+K E LL  MLP SVA  L K   V  E +DLVT++FSDIVGFT +SA S P++++DLLN LYT FD+II ++DVYKVETIGDAYMV SGLP+ NG+ HA EIA M++  LS++  F + H P+  +++RIG+HSGPV +GVVGL MPRYCLFGDTVNT+SRMES GLP++IH+S ST+ +L+        E RG  E+KGKG+ +T+WL G+   +  P+P
Sbjct:  598 MKDLRHENINPLLGFFYDSGMFAIVTEFCSRGSLEDILTNQDVKLDWMFKSSLLLDLIKGMKYLHHREFVHGRLKSRNCVVDGRFVLKVTDYGFNDIL---EMLRLSEEESSMEELLWTAPELLRAPRGSRLGSFAGDVYSFAIIMQEVMVRGTPFCMM---DLPAQEIINRLKKPPPVYR---PVVPPEHAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNK-GKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQNLSEGYEVELRGRTELKGKGTEETFWLIGKKGFM-KPLP 1071

HSP 2 Score: 55.0694 bits (131), Expect = 1.081e-6
Identity = 42/187 (22.46%), Postives = 82/187 (43.85%), Query Frame = 3

Query:  885 GNKYAVAVLCVDPASV-----HRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEF 1430
             ++  + ++C+  A +       +L  A  L   +G YVF+           K+  Y    N   N + + AY ++L++T++  E   ++ F++     A  E     E D ++      Y+ +   A A+N  + + G     SL+ ++  N  F G    +  DS+G+ I+++ ILD + K  E 
Sbjct:  239 ADRIRIIIMCMHSALIGGETQMHLLECAHDLKMTDGTYVFVPYDALLYSLPYKHTPYRVLRN---NPKLREAYDAVLTITVESQEKTFYQAFTEAA---ARGEIPEKLEFDQVSPLFGTIYNSIYFIAQAMNNAMKENGQAGAASLV-QHSRNMQFHGFNQLMRTDSNGNGISEYVILDTNLKEWEL 418

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BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2D (guanylate cyclase 2D, retinal [Source:HGNC Symbol;Acc:HGNC:4689])

HSP 1 Score: 429.483 bits (1103), Expect = 1.603e-130
Identity = 239/529 (45.18%), Postives = 339/529 (64.08%), Query Frame = 3

Query: 2034 ALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIG----------ACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLD--GTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTE-RGHIEVKGKGSTQTYWLHGENELIVDPIPK 3581
             +Y+G+ V LK     + I I         K+++L ++++  ++G          A L  G   +V ++C +GSL+D+LA+ +I LDW+FK SL+ D+ +G+ YLH+     G LKS NC+VD RFVLKITD G   L  +++ L E       ++ LWTAPELLR  +P L+  GT  GDV+S AI+ QE+V R   +++    + + +E+V+ V+   SP P    L ++     + +LL+KQ W E P LRP  +      +  NK G   NI+D++L  +EQY++NLED+++ERTE+   EK+K + LL  MLP SVA  L    PV  E ++ VT++FSDIVGFT +SA S P++++DLLN LYT FD+II ++DVYKVETIGDAYMV SGLPQ NG  HA EIA M++  LSA+  F + H P+  +++RIG+HSGP  +GVVGL MPRYCLFGDTVNT+SRMES GLP++IH++ ST+ +L+   +    E RG  E+KGKG+  T+WL G       PIPK
Sbjct:  553 GVYEGDRVWLKKFPGDQHIAIRPATKTAFSKLQELRHENVALYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLHHRGVAHGRLKSRNCIVDGRFVLKITDHGHGRLLEAQKVLPEPPRA---EDQLWTAPELLR--DPALERRGTLAGDVFSLAIIMQEVVCRSAPYAML---ELTPEEVVQRVR---SPPPLCRPLVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINK-GRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNLSTVGILRALDSGYQVELRGRTELKGKGAEDTFWLVGRRGF-NKPIPK 1068

[Close]

BLAST of Guanylate cyclase vs. Ensembl Human
Match: GUCY2C (guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:4688])

HSP 1 Score: 391.349 bits (1004), Expect = 7.727e-117
Identity = 223/492 (45.33%), Postives = 306/492 (62.20%), Query Frame = 3

Query: 2112 IQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAK-----EQITLDWVFKYSLIQDICRGMVYLHNNLGPI-GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSL---TAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRK-FNKEGDSGN--ILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLK-TFGTFLMTERGHIEVKGKGSTQTYWLHG 3548
            I++ K+  ++  ++ +F G        + V +YC +GSL +VL       +   +DW FK S++ DI +GM YLH++   + G LKS+NC+VDSR V+KITDFG  S+   K+ L             WTAPE LR +N     + KGDVYS+ I+ QEI+ RK  F   S  D    E +  V+  N   PFRP L   TA     E + LL+K  W EDP  RPDF  I+  + K F    D  N   +D L+ R++ Y+ NLE +V+ERT+ Y  E+ +A+ L + +LP+ V   L +   V  E Y+ VTI+FSDIVGFT +   STPM+++D+LN +Y +FD I++++DVYKVETIGDAYMV SGLP+ NGN HA +IA+MA+  LS +  F + H P   + +RIG+HSGP  +GVVG+KMPRYCLFGDTVNT+SRMES GLP +IH+S ST+ +LK T   FL   RG   +KG+G+  TYWL G
Sbjct:  531 IELNKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVLNDTISYPDGTFMDWEFKISVLYDIAKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDL-------------WTAPEHLRQANI----SQKGDVYSYGIIAQEIILRKETFYTLSCRD--RNEKIFRVENSNGMKPFRPDLFLETAEEKELEVY-LLVKNCWEEDPEKRPDFKKIETTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDIAKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG 1002

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BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 566.614 bits (1459), Expect = 0.000e+0
Identity = 295/582 (50.69%), Postives = 405/582 (69.59%), Query Frame = 3

Query: 1878 VEKPSSKLSRNNSKNFGNP---IYKDLDL------ISCASLETIAGINLDKI--QNAQLFTKTALYKGNVVALKPI----LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEE-DSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPN--PFRPSLTAIHGCTEDFVL------LIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHG 3548
            V  PSS+ +R  + N  +P     K L L          S ++ +G +++ I   N Q++TKTA++KG VVA+K +        R+D++R  L+++KK+KDL +DHI RF GAC++  +  +V +YCPKGSLED+L  E+I LD + KYSL+ D+ +G+ +LHN+ +   G LKSSNC+VDSRFVLK+TDFGL  L   ++  LEE   + Y+K +LWTAPELLR SN P  GT KGD+YSFAI+  E+++RKGVF+L++ED  S  EIV+ V+   S +  P RP ++       D  L      L+   W+EDP  RP+ ++++  +R  N++ ++ N++DNLL RMEQYANNLE +V+ERT++YL EKKK E+LL+ +LP ++A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + HA +IA+M+++ L  +  FVI HRP ++LKLRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLP KIH+SQ T  +L     F +  RG +E+KGKG   TYWL G
Sbjct:  645 VSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED-LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1224

HSP 2 Score: 230.335 bits (586), Expect = 2.731e-61
Identity = 153/445 (34.38%), Postives = 227/445 (51.01%), Query Frame = 3

Query:  444 GVQTFVTQMPDVLFGPICGYVLAPIARLLAFWN--IPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWP-IRQYKEXXXXXXXXXXXXEQF--LIDAIGNKYAVAVLCVDPASVHRILLKADQLNF-NNGEYVFINIGLFSSGNETKYPW-YLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNY------HYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVY--RNIKLQAELNAMNWIIPWESLETSE 1733
             V+  + +  D + G   GY LAP+AR+  +W   IPI++   +      +R  E++ +TRI S +   V+   +   F  YKW   I+++H     +V    C  L   L       ++       + E   A ++      QF   + A  N   V +LC  P +V  I+L A  L    +GEYVFINI + S+G+  + PW     +N  EN +AK AYR+L +++L+  + ++++NF  +VKE A ++YNY       YE   +N F+S FYD VLLYA ALN+T+  G    NG  I   MW  TF GI G V+ID +GDR +D+S+LD+DP    F  VA++ G  +    V  +   W  V    P+  P CGYD S CP+    L++  +    MG   LI    G F++  R  KL+ EL AM+W I WE L+  E
Sbjct:  110 AVEQLLRKQIDCIIGYAYGYALAPVARMSPYWKNGIPIITPIGLTMSLDDKR--EYQLMTRINSPYK--VVSSAVSTLFNTYKWKRHIFMFHHAKAPSVAVGECFLLMASLQHPLRKVMEMQHNFFTFNEDHGANISKAERHNQFRNYLRASSNMANVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYE---MNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLH--W--VGGKPPTDLPICGYDKSKCPQ-GYPLHVYLL----MGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEE 537

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Query: 1878 VEKPSSKLSRNNSKNFGNP---IYKDLDL------ISCASLETIAGINLDKI--QNAQLFTKTALYKGNVVALKPI----LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEE-DSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPN--PFRPSLTAIHGCTEDFVL------LIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHG 3548
            V  PSS+ +R  + N  +P     K L L          S ++ +G +++ I   N Q++TKTA++KG VVA+K +        R+D++R  L+++KK+KDL +DHI RF GAC++  +  +V +YCPKGSLED+L  E+I LD + KYSL+ D+ +G+ +LHN+ +   G LKSSNC+VDSRFVLK+TDFGL  L   ++  LEE   + Y+K +LWTAPELLR SN P  GT KGD+YSFAI+  E+++RKGVF+L++ED  S  EIV+ V+   S +  P RP ++       D  L      L+   W+EDP  RP+ ++++  +R  N++ ++ N++DNLL RMEQYANNLE +V+ERT++YL EKKK E+LL+ +LP ++A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + HA +IA+M+++ L  +  FVI HRP ++LKLRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLP KIH+SQ T  +L     F +  RG +E+KGKG   TYWL G
Sbjct:  624 VSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED-LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1203

HSP 2 Score: 214.157 bits (544), Expect = 3.199e-56
Identity = 144/445 (32.36%), Postives = 226/445 (50.79%), Query Frame = 3

Query:  447 VQTFVTQMPDVLFGPICGYVLAPIARLLAFWN--IPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYT---NVIPLYCH-ALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNF-NNGEYVFINIGLFSSGNETKYPW-YLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNY------HYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVY--RNIKLQAELNAMNWIIPWESLETSE 1733
            ++ +  +  D + G    Y LAP+AR+  FW   +P+ +T A+        ++EF  LTR+   +  L  G+++ +  ++++W H  ++++        N     C+ +L              W ++ + E     L       + L+        + +LC  P +V  I+L A  L    +GEYVFINI + S+G+  + PW     +N  EN +AK AYR+L +++L+  + ++++NF  +VKE A ++YNY       YE   +N F+S FYD VLLYA ALN+T+  G    NG  I   MW  TF GI G V+ID +GDR +D+S+LD+DP    F  VA++ G  +    V  +   W  V    P+  P CGYD S CP+    L++  +    MG   LI    G F++  R  KL+ EL AM+W I WE L+  E
Sbjct:   94 IEHYCNKTVDAIMGLPYVYALAPVARISKFWGQGVPVFTTTALVDELGD--RNEFPLLTRMMGSYKSL--GKLVTRIAERFEWQHYFFMFNDEVARGPRNKGRSECYFSLSAIKNLIMNNKTSTWNVKMFSEFEADRLQY-----RALLSEASVMSNLIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYE---MNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLH--W--VGGKPPTDLPICGYDKSKCPQ-GYPLHVYLL----MGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEE 516

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 566.614 bits (1459), Expect = 1.418e-180
Identity = 295/582 (50.69%), Postives = 405/582 (69.59%), Query Frame = 3

Query: 1878 VEKPSSKLSRNNSKNFGNP---IYKDLDL------ISCASLETIAGINLDKI--QNAQLFTKTALYKGNVVALKPI----LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEE-DSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPN--PFRPSLTAIHGCTEDFVL------LIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHG 3548
            V  PSS+ +R  + N  +P     K L L          S ++ +G +++ I   N Q++TKTA++KG VVA+K +        R+D++R  L+++KK+KDL +DHI RF GAC++  +  +V +YCPKGSLED+L  E+I LD + KYSL+ D+ +G+ +LHN+ +   G LKSSNC+VDSRFVLK+TDFGL  L   ++  LEE   + Y+K +LWTAPELLR SN P  GT KGD+YSFAI+  E+++RKGVF+L++ED  S  EIV+ V+   S +  P RP ++       D  L      L+   W+EDP  RP+ ++++  +R  N++ ++ N++DNLL RMEQYANNLE +V+ERT++YL EKKK E+LL+ +LP ++A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + HA +IA+M+++ L  +  FVI HRP ++LKLRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGLP KIH+SQ T  +L     F +  RG +E+KGKG   TYWL G
Sbjct:  683 VSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED-LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLPLKIHVSQQTYDILMQEAGFKLELRGSVEMKGKGMQTTYWLRG 1262

HSP 2 Score: 203.371 bits (516), Expect = 8.402e-53
Identity = 164/537 (30.54%), Postives = 253/537 (47.11%), Query Frame = 3

Query:  267 MLMLPK------NFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEP--VDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWN--IPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQ-----------KTFKKYKWTHGIYIYH-------------KTAYTNVIPLYCH----ALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNF-NNGEYVFINIGLFSSGNETKYPW-YLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNY------HYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVY--RNIKLQAELNAMNWIIPWESLETSE 1733
            +++LPK      NF M      +P I IA+++V     + P   +L   +    + I +   +A    +Q +     D + G    Y LA + ++ A  N  IPIL+T  +        K E+  LTR+  G   L+   M Q           K+     + + I+ YH             ++  T     +C+    A+  Y T++ +     W +   +      L  +    +  +  I  +  V +LC  P +V  I+L A  L    +GEYVFINI + S+G+  + PW     +N  EN +AK AYR+L +++L+  + ++++NF  +VKE A ++YNY       YE   +N F+S FYD VLLYA ALN+T+  G    NG  I   MW  TF GI G V+ID +GDR +D+S+LD+DP    F  VA++ G  +    V  +   W  V    P+  P CGYD S CP    ++ +      +MG   LI    G F++  R  KL+ EL AM+W I WE L+  E
Sbjct:   44 IVILPKRESTYDNFGM-TLQKAMPVIDIAVQEVIKAKKLPPGWINLTYWDSRLYEDILLAERHATVGVIQAYCEHRLDAILGFADNYGLATVTKVTAGLNGGIPILTTSGMPSLLNS--KKEYPFLTRM-QGSYRLLADSMYQLIAYHDEDSVSKSNSSLNYLNLIFFYHDKRRAVNRVIAQDESQETGATSSHCYFSLYAIKRYFTEKSKTFKREWALNTPQFPFDEDLVIERETFKQWLREISLQSNVIILCASPDTVREIMLAAHDLGMATSGEYVFINIDV-STGSHAEQPWIRANDTNNEENEKAKEAYRALKTISLRRSDLDEYKNFELRVKERADQKYNYTNITGKDYE---MNNFISAFYDAVLLYAIALNETIQSGLDPRNGHNITSRMWGRTFVGITGNVSIDHNGDRYSDYSLLDLDPVQNRFVEVAYYSGASNQLKTVGQLH--W--VGGKPPTDLPICGYDKSKCPGYPLHVYL------LMGSFLLILVLVGLFIFFWRRYKLEQELAAMSWKIRWEELDGEE 562

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-28 (Receptor-type guanylate cyclase gcy-28 [Source:UniProtKB/Swiss-Prot;Acc:Q86GV3])

HSP 1 Score: 529.635 bits (1363), Expect = 2.551e-174
Identity = 284/577 (49.22%), Postives = 393/577 (68.11%), Query Frame = 3

Query: 1878 VEKPSSKLSRNNSKNFGNP---IYKDLDL------ISCASLETIAGINLDKI--QNAQLFTKTALYKGNVVALKPI----LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEE-DSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPN--PFRPSLTAIHGCTEDFVL------LIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGT-----FLMTERGHIEVKGK 3518
            V  PSS+ +R  + N  +P     K L L          S ++ +G +++ I   N Q++TKTA++KG VVA+K +        R+D++R  L+++KK+KDL +DHI RF GAC++  +  +V +YCPKGSLED+L  E+I LD + KYSL+ D+ +G+ +LHN+ +   G LKSSNC+VDSRFVLK+TDFGL  L   ++  LEE   + Y+K +LWTAPELLR SN P  GT KGD+YSFAI+  E+++RKGVF+L++ED  S  EIV+ V+   S +  P RP ++       D  L      L+   W+EDP  RP+ ++++  +R  N++ ++ N++DNLL RMEQYANNLE +V+ERT++YL EKKK E+LL+ +LP ++A  LI  + V AESYD VTI+FSDIVGFT+LS++STPMQ++ LLN LY  FD +++N+ VYKVETIGDAYMV SGLP+   + HA +IA+M+++ L  +  FVI HRP ++LKLRIG+HSG V +GVVG KMPRYCLFGDTVNTSSRMESNGL    + S   +   K F       FL  E+  IE +GK
Sbjct:   56 VSSPSSEATRKKNSNEEDPENGAKKSLSLKNRKLSFGMVSFKSGSGGSVETIAQNNTQIYTKTAIFKGVVVAIKKLNIDPKKYPRLDLSRAQLMELKKMKDLQHDHITRFTGACIDFPHYCVVTEYCPKGSLEDILENEKIELDKLMKYSLLHDLVKGLFFLHNSEIRSHGRLKSSNCVVDSRFVLKVTDFGLHRLHCLEEINLEEIGEHAYYKKMLWTAPELLRDSNAPPMGTQKGDIYSFAIILHEMMFRKGVFALENED-LSPNEIVQRVRKPVSEDQEPLRPWVSETGEGEGDDALNDTLLSLMVACWSEDPHERPEVSSVRKAVRSLNRDNETSNLVDNLLKRMEQYANNLEGLVEERTQEYLAEKKKVEELLHQLLPPAIADTLIAGRAVQAESYDCVTIYFSDIVGFTSLSSQSTPMQVVTLLNDLYLAFDGVVDNFKVYKVETIGDAYMVVSGLPERRDD-HANQIAQMSLSLLHKVKNFVIRHRPHEQLKLRIGMHSGSVVAGVVGSKMPRYCLFGDTVNTSSRMESNGLRMFWNFSLYKIYKFKVFKNKIELDFLKNEKESIEFEGK 630

[Close]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Match: gcy-7 (Receptor-type guanylate cyclase gcy-7 [Source:UniProtKB/Swiss-Prot;Acc:H2L002])

HSP 1 Score: 457.603 bits (1176), Expect = 2.394e-141
Identity = 332/1059 (31.35%), Postives = 535/1059 (50.52%), Query Frame = 3

Query:  474 DVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDA---IGNKYAVAVLCV-DPASVHR-ILLKADQLNFNNGEYVFINIGLFSSG-------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASR--EYNYHYEKD-------LINTFVSNFYDGVLLYAHALNKTLADG--GAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFL--VVPNVSVDWGSV-SNVIPSTKPRCGYDNSMCPKP--DKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQ-AELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRS-QNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLL--IKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            DV+ GP           +  ++N PI++ G V    + +    F     + +G   L  G  I+   K+Y+W+  +Y Y     T       + L   ++   +I + Y            ++         +I+A   I ++  + V C+ D   + R  LL A++      EYV++   + S G          +  W L+  +   ++RA +A++  + +   + +     N++   +E+ +R  E  Y   KD       +  T+    +D V  Y  AL+K L  G      N +  ++  +  +F G+ G VTI+  G R     +L +D      +    ++   S+    +  +  V W S  +N  P   P CG+  ++CPK   D+ L I  I A V+  LFL   +A   +Y +I+ +  E+  +N +                      +Q   IH     +HQ  S Q  KG        H +  ++  +S LS   + +F                         + +N   F+         V  K    + R+D ++   +  + +++L+ D++ RFIG CL+      V+ +C +GS+ DV+ K  I +D  F YSLI+D+  G+V+LH ++ G  G L S  CL+D R+ +KI+++GL  LR  + Y  E+      K+LLW+APELLR  +  + G+ +GDVYS  I+C E++ RKGVF+++   +   +EI+  +K     +P RP L   H    +  LL  ++  + E P  RP   T++  +R  N   +  N++D++ + +E YA++LE+ V ERT++ +EEKKK++ LLY MLPK+VA +L   Q V  E+++ VTIFFSD+V FT L+++ TP+Q+++LLN LYT FD IIE +DVYKVETIGD Y+  SGLP  NGN H R+IA M++AFLS++  F +PH P + + LRIG++ G V +GVVGL MPR+CLFGD VNT+SRMESNG P KIH+S    ++L   G F    RG + +KGKG  +T+WL G+
Sbjct:  107 DVIIGPTMNQPTLAAFIVSNYFNRPIIAWGLVNAA-QLDDFERFPNAGILSAGQRSL--GVAIRAVLKRYEWSQFVYAYFTEEDTEKCVTMRNDLQQVVSYFGDIILAY------------SIQVADISNDGMIEALKKIQSRGRIIVTCMKDGIGLRRKWLLAAEEAGMIGDEYVYVFSDIKSKGYVVPLLGGGERPSWILSTGSDENDTRALKAFKQSIFICDMMGQGSIATNYTIFGQEIIARMKEAPYFCTKDCEGENFTVAATYAGQLHDAVYAYGVALDKMLKAGQIAQYRNATAFMR-YFPQSFIGMSGNVTINEKGTRNPTLFLLALDENNNNTRMATIYVENMSATFNALYSDEGVMWASRKNNARPVDVPLCGFTGNLCPKSFVDEYL-IWVIVAIVV--LFLAITAAACGIYFSIQARRQEIERLNRL----------------------WQIPFIH-----LHQINSKQKGKGE-------HSVRSLQSGTSTLSSRTTVSFKT-----------------------ESRNFLFFSLQRESDYEPVVAKKHAYRPRLDDDKCTFM--RSLRNLDQDNLNRFIGLCLDGPQMLSVWRFCSRGSIADVILKATIQMDNFFIYSLIKDMVHGLVFLHGSMVGYHGMLTSKCCLIDDRWQVKISNYGLQDLRSPEMY--EK------KDLLWSAPELLRAED--IKGSKEGDVYSLGIICAELITRKGVFNMEDRKE-DPEEIIYLLKKGGLKSP-RPDLEYDHTIEINPALLHLVRDCFTERPSERPSIETVRSQLRGMNSSRND-NLMDHVFNMLESYASSLEEEVSERTKELVEEKKKSDVLLYRMLPKTVADKLKLGQTVEPETFEQVTIFFSDVVQFTTLASKCTPLQVVNLLNDLYTIFDGIIEKHDVYKVETIGDGYLCVSGLPHRNGNEHVRQIALMSLAFLSSLQFFRVPHLPSERINLRIGMNCGSVVAGVVGLTMPRFCLFGDAVNTASRMESNGKPGKIHVSAEANRMLHLVGGFDTESRGEVIIKGKGVMETFWLTGQ 1074

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0346151)

HSP 1 Score: 814.683 bits (2103), Expect = 0.000e+0
Identity = 465/1106 (42.04%), Postives = 668/1106 (60.40%), Query Frame = 3

Query:  306 PLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDV--LFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHK---TAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNF-NNGEYVFINIGLFSSGNE-TKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHY-EKDLINTFVSNFYDGVLLYAHALNKTLADGGAI----SNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHN-NLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEED-----SNMYFKNLLWTAPELLRMS-NPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDS-EDDFSAQEIVESVKAENS---PNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            P  +P +++A+  V+ M ++      ++ +   D+ C  + Y    G     TQ P+V  +FG  C YVLAPI+R    W +P+L+TG     F K+ +S + TLTR+    ++  LG +++     + WT    IY         N +   C A      +E  +    +    + +               ++  +  +  + ++C DP S+ +I+L A++LN  ++GEYVFINI LFS     T  PWY        N RA++AY ++L+VT K P + ++   S+++K +A+ +YNY + + + I+ FV++F+DGVLLYA+ALN+++ +   +     NG+ +++ MWN +F GI G VTID++GDR++ +S+LDM+P TG F+ VAHF+  +  F    N  + W       P  +P CGYD ++CP  D +L   AI + V+G + ++     +F YR+   +AE+N+M+W +  E                            V    +  + L+G+          H + K SS+L+                L+S    E +  IN D+    Q+F    +++ + VA+KP+ +   +  + R L++++K++KDL +DH+ +F GACL+    +++ +YCPKGSL+D+L  EQ  LDW+F+ SL+ DI RGM +LH+ ++   G LKSSNC+VDSRFVLKITDFGL +LR ++ + LE D     S+ Y+  LLWTAPELLR+  N P +GT KGDVY+F I+  EI  R+G F L     + S QEI+E VK  N      PFRP L        D   +I++ W EDP  RPDFNT+K  +R+FNK+ ++GNI+DNLL RME YANNLE++V+ERT+ Y EEKKK E LLY +LP+SVA QLI  QPV AE++D VTI+FSDIVGFTA+SAESTPMQ++  LN LYT FDSI+EN+DVYKVETIGDAYMV SGLP  NGN HAREIAR+A+A L A+  F I HRP+  LKLRIG+H+G   +GVVGLKMPRYCLFGDTVNT+SRMESNG   KIHIS++T + L  FGTF+ T RG + +KGKG   TYWL GE
Sbjct:  106 PKVLPVLELAIRHVQRMGFVGGSHFDIQLIS-RDTFC-SSKYGPI-GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSES-YSTLTRLKGAQVN-NLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITR----------MLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEA--NKEIHWAGDREEAPPDRPICGYDGALCP--DNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLED---------------------------VMFRDAAERGLRGS---------FHSLVKQSSQLT----------------LMS----EDMVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTR-FDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG31183 (gene:FBgn0051183 transcript:FBtr0083187)

HSP 1 Score: 814.683 bits (2103), Expect = 0.000e+0
Identity = 465/1106 (42.04%), Postives = 668/1106 (60.40%), Query Frame = 3

Query:  306 PLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDV--LFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHK---TAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNF-NNGEYVFINIGLFSSGNE-TKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHY-EKDLINTFVSNFYDGVLLYAHALNKTLADGGAI----SNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHN-NLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEED-----SNMYFKNLLWTAPELLRMS-NPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDS-EDDFSAQEIVESVKAENS---PNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            P  +P +++A+  V+ M ++      ++ +   D+ C  + Y    G     TQ P+V  +FG  C YVLAPI+R    W +P+L+TG     F K+ +S + TLTR+    ++  LG +++     + WT    IY         N +   C A      +E  +    +    + +               ++  +  +  + ++C DP S+ +I+L A++LN  ++GEYVFINI LFS     T  PWY        N RA++AY ++L+VT K P + ++   S+++K +A+ +YNY + + + I+ FV++F+DGVLLYA+ALN+++ +   +     NG+ +++ MWN +F GI G VTID++GDR++ +S+LDM+P TG F+ VAHF+  +  F    N  + W       P  +P CGYD ++CP  D +L   AI + V+G + ++     +F YR+   +AE+N+M+W +  E                            V    +  + L+G+          H + K SS+L+                L+S    E +  IN D+    Q+F    +++ + VA+KP+ +   +  + R L++++K++KDL +DH+ +F GACL+    +++ +YCPKGSL+D+L  EQ  LDW+F+ SL+ DI RGM +LH+ ++   G LKSSNC+VDSRFVLKITDFGL +LR ++ + LE D     S+ Y+  LLWTAPELLR+  N P +GT KGDVY+F I+  EI  R+G F L     + S QEI+E VK  N      PFRP L        D   +I++ W EDP  RPDFNT+K  +R+FNK+ ++GNI+DNLL RME YANNLE++V+ERT+ Y EEKKK E LLY +LP+SVA QLI  QPV AE++D VTI+FSDIVGFTA+SAESTPMQ++  LN LYT FDSI+EN+DVYKVETIGDAYMV SGLP  NGN HAREIAR+A+A L A+  F I HRP+  LKLRIG+H+G   +GVVGLKMPRYCLFGDTVNT+SRMESNG   KIHIS++T + L  FGTF+ T RG + +KGKG   TYWL GE
Sbjct:  106 PKVLPVLELAIRHVQRMGFVGGSHFDIQLIS-RDTFC-SSKYGPI-GFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSES-YSTLTRLKGAQVN-NLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADITR----------MLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEA--NKEIHWAGDREEAPPDRPICGYDGALCP--DNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLED---------------------------VMFRDAAERGLRGS---------FHSLVKQSSQLT----------------LMS----EDMVSINGDR----QIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTR-FDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302487)

HSP 1 Score: 547.74 bits (1410), Expect = 1.073e-173
Identity = 331/810 (40.86%), Postives = 461/810 (56.91%), Query Frame = 3

Query: 1206 INTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFE-GIGGTVTIDSSGDRIADFSILDMDP-KTGE------FKPVAHFIGTKSSF----LVVPNVS----VDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKN-----LLWTAPELLRMSNPPL-DGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESV-KAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            I+   +  YD V LYA AL + L  GG   NGS I+  +  + +   +G  V ID +GD   ++++L     + G        +PV  FI   SS       +PN+     +DW  V    P+  PRCG+    C         G ISA + G   L+       +YRN + + EL+++ W I +  ++  E  R                           Q+ K TR      HLL+        L R       +P      LI  + +   +  + D  +   +FT   LYKG + A+K +  ++ +DI R++  ++K ++D  +D+IC FIGAC +     ++ +YC +GSL+D+L  E + LD +F  S++ DI RG++YLH++  PI   G L +SNCLVDSR+V+K+TDFGL +    KQ + +  ++M   +     LL+ APELLR     L  GT +GD YSF I+  E+  R+G F    E   +  + ++ V + ++  NP+RPSL  +    +     +++ W E P  RPDF TI+  +R   K G   NI DN+++ ME+YANNLE +V +RT+Q  EEKKK + LL+ MLP+ VA QL K   V+ E Y+ V+I+FSDIVGFTA+SAE TP+Q++D LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LHA EIA M++  LSA+  F I HRP   L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+P KIH S    QLL   G +   ERG I +KGKG  +TYWL GE+E
Sbjct:  353 ISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN-----YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENERE-------------------------QQSQKQTR------HLLNH-------LPRRLPPQSTHP------LIRTSQVSLSSNPDAD-FRYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAF---KQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFG---ETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1100

[Close]

BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0302488)

HSP 1 Score: 545.043 bits (1403), Expect = 1.088e-172
Identity = 329/812 (40.52%), Postives = 458/812 (56.40%), Query Frame = 3

Query: 1206 INTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFE-GIGGTVTIDSSGDRIADFSILDMDP-KTGE------FKPVAHFIGTKSSFLVVPNV----------SVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKN-----LLWTAPELLRMSNPPL-DGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESV-KAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            I+   +  YD V LYA AL + L  GG   NGS I+  +  + +   +G  V ID +GD   ++++L     + G        +PV  FI   SS   +              +DW  V    P+  PRCG+    C         G ISA + G   L+       +YRN + + EL+++ W I +  ++  E  R                           Q+ K TR      HLL+        L R       +P      LI  + +   +  + D  +   +FT   LYKG + A+K +  ++ +DI R++  ++K ++D  +D+IC FIGAC +     ++ +YC +GSL+D+L  E + LD +F  S++ DI RG++YLH++  PI   G L +SNCLVDSR+V+K+TDFGL +    KQ + +  ++M   +     LL+ APELLR     L  GT +GD YSF I+  E+  R+G F    E   +  + ++ V + ++  NP+RPSL  +    +     +++ W E P  RPDF TI+  +R   K G   NI DN+++ ME+YANNLE +V +RT+Q  EEKKK + LL+ MLP+ VA QL K   V+ E Y+ V+I+FSDIVGFTA+SAE TP+Q++D LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LHA EIA M++  LSA+  F I HRP   L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+P KIH S    QLL   G +   ERG I +KGKG  +TYWL GE+E
Sbjct:  353 ISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPHQNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN-----YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENERE-------------------------QQSQKQTR------HLLNH-------LPRRLPPQSTHP------LIRTSQVSLSSNPDAD-FRYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAF---KQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFG---ETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1102

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BLAST of Guanylate cyclase vs. Ensembl Fly
Match: CG10738 (gene:FBgn0036368 transcript:FBtr0304792)

HSP 1 Score: 543.502 bits (1399), Expect = 2.884e-172
Identity = 329/810 (40.62%), Postives = 456/810 (56.30%), Query Frame = 3

Query: 1206 INTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFE-GIGGTVTIDSSGDRIADFSILDMDP-KTGE------FKPVAHFIGTKSSFL----VVPNVS----VDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKN-----LLWTAPELLRMSNPPL-DGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESV-KAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            I+   +  YD V LYA AL + L  GG   NGS I+  +  + +   +G  V ID +GD   ++++L     + G        +PV  FI   SS       +PN+     +DW  V    P+  PRCG+    C         G ISA + G   L+       +YRN + + EL+++ W I +  ++  E  R                           Q+ K TR+     H L    + S  LS N   +F                           +   +FT   LYKG + A+K +  ++ +DI R++  ++K ++D  +D+IC FIGAC +     ++ +YC +GSL+D+L  E + LD +F  S++ DI RG++YLH++  PI   G L +SNCLVDSR+V+K+TDFGL +    KQ + +  ++M   +     LL+ APELLR     L  GT +GD YSF I+  E+  R+G F    E   +  + ++ V + ++  NP+RPSL  +    +     +++ W E P  RPDF TI+  +R   K G   NI DN+++ ME+YANNLE +V +RT+Q  EEKKK + LL+ MLP+ VA QL K   V+ E Y+ V+I+FSDIVGFTA+SAE TP+Q++D LN LYT FDSII +YDVYKVETIGDAYMV SGLP  NG+LHA EIA M++  LSA+  F I HRP   L LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES+G+P KIH S    QLL   G +   ERG I +KGKG  +TYWL GE+E
Sbjct:  353 ISAEAAYLYDAVHLYAKALMEVLDSGGRPRNGSAIVAAIKGSRYRSAMGYHVYIDENGDAAGNYTVLARGSVRNGRNQTVLGLRPVGTFIHRNSSLSSISKALPNLKLFSPIDW--VGGTRPAAAPRCGFGGEKCVN-----YTGEISAAIAGGALLLLSLVSLVLYRNWRYEQELDSLLWKIDFREVQIHENERE-------------------------QQSQKQTRST----HPLIRTSQVS--LSSNPDADF---------------------------RYTTIFTPIGLYKGQLYAIKKV-RKKSVDITREMKKELKLLRDARHDNICAFIGACTDPPNICIISEYCTRGSLKDILENEDVKLDNMFIASMVADIIRGVIYLHDS--PIRFHGALCTSNCLVDSRWVVKLTDFGLFAF---KQGIEDSSTDMQHMSAKCLKLLYRAPELLRQGPSSLVMGTQRGDAYSFGILLYEMHVRRGPFG---ETGLTPMQCLQKVLQPQDYLNPYRPSLQPLETAFDCVSECLRECWAERPEDRPDFKTIRTKLRPLRK-GMRPNIFDNMMAMMEKYANNLEALVDDRTDQLQEEKKKTDALLHEMLPRCVADQLKKGHKVDPEHYEQVSIYFSDIVGFTAMSAECTPLQVVDFLNDLYTCFDSIIGHYDVYKVETIGDAYMVVSGLPLRNGDLHAAEIATMSLHLLSAVSEFKIRHRPTNRLLLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESSGVPLKIHCSWQCRQLLDRLGGYHFAERGVISMKGKGDQRTYWLLGEDE 1087

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 751.125 bits (1938), Expect = 0.000e+0
Identity = 451/1138 (39.63%), Postives = 656/1138 (57.64%), Query Frame = 3

Query:  174 ISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPW--PLTIPAIKIALEKVKSMP-----YMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLT-QEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLF--SSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            +SF V   E    ++ Q  +     +   LA++ LP + + +PW  P   PA+  ALEKV S P     Y   +V    + E  + +C ++   L   V    +  P    GP C Y  +P+AR    W +P++++GA   GF     + + ++T IG  H  L  G+ + +  + + W     +       +  P Y    G Y   +E  IT D     + +E               L+  I +K  V  +C    +  +++++  +  F   EY F  I LF  S  +    PW   A   ++++ AK A++S+  +T + P+N ++++F  ++K  A   +N++ E  L+N    +F+DGV+LY+HALN T+   G+   G ++ K MWN T+ G+ G V +D +GDR  DF++ DM D KTG+++ V+ + G++   ++ P + V W  +    P   P CG+ N       K + +  + + V+  +F+I  +   F+YR +KL+ EL A  W + WE ++ S     ++   C          SK+ +      +L+G+                          N+G             SL T+ G       N Q++ KT  YKGN+ A+K  ++++RI++ R++L ++K ++D+ N+H+ RFIGAC++     ++ +YCP+GSL+D++  E ITLDW+F+YSLI DI +GM +LHN+ +   G LKSSNC+VDSRFVLKITD+GL S          +D + ++   LWTAPELLR  NPP  GT KGDVYSF I+ QE+   KGVF L+     S +EI+E V     P   RP L      +E+   L+ + W+ED   RPDF+ IK  +RK N  G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPM+++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIARM++A L A+  F I HRP+ +L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S++T  +L+ F  F +  RG +E+KGKG  +TYWL GE
Sbjct:   20 VSFGVVELEPVPENQPQSPSAHASQKNITLAVI-LPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLV--FNSSENKEGLCSDSVAPLV-AVDLKFSYNPWAFIGPGCDYSSSPVARFTTHWEVPMITSGARALGF-----NLYSSITNIGPTHKKL--GEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYDE---------LLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW---ARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW--LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMS-NTEKVLRRAC----------SKLTI------SLRGS--------------------------NYG-------------SLLTMDG-------NFQIYAKTGYYKGNITAIK-YVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNL---DDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPC-LSPKEIIERVVEGRWPY-LRP-LLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061

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Query:  174 ISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPW--PLTIPAIKIALEKVKSMP-----YMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLT-QEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLF--SSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            +SF V   E    ++ Q  +     +   LA++ LP + + +PW  P   PA+  ALEKV S P     Y   +V    + E  + +C ++   L   V    +  P    GP C Y  +P+AR    W +P++++GA   GF     + + ++T IG  H  L  G+ + +  + + W     +       +  P Y    G Y   +E  IT D     + +E               L+  I +K  V  +C    +  +++++  +  F   EY F  I LF  S  +    PW   A   ++++ AK A++S+  +T + P+N ++++F  ++K  A   +N++ E  L+N    +F+DGV+LY+HALN T+   G+   G ++ K MWN T+ G+ G V +D +GDR  DF++ DM D KTG+++ V+ + G++   ++ P + V W  +    P   P CG+ N       K + +  + + V+  +F+I  +   F+YR +KL+ EL A  W + WE ++ S     ++   C          SK+ +      +L+G+                          N+G             SL T+ G       N Q++ KT  YKGN+ A+K  ++++RI++ R++L ++K ++D+ N+H+ RFIGAC++     ++ +YCP+GSL+D++  E ITLDW+F+YSLI DI +GM +LHN+ +   G LKSSNC+VDSRFVLKITD+GL S          +D + ++   LWTAPELLR  NPP  GT KGDVYSF I+ QE+   KGVF L+     S +EI+E V     P   RP L      +E+   L+ + W+ED   RPDF+ IK  +RK N  G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPM+++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIARM++A L A+  F I HRP+ +L+LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S++T  +L+ F  F +  RG +E+KGKG  +TYWL GE
Sbjct:   20 VSFGVVELEPVPENQPQSPSAHASQKNITLAVI-LPLHNTEYPWAWPRVGPALYWALEKVNSDPNLLAGYHLQLV--FNSSENKEGLCSDSVAPLV-AVDLKFSYNPWAFIGPGCDYSSSPVARFTTHWEVPMITSGARALGF-----NLYSSITNIGPTHKKL--GEFVLRMHRHFGWDKHAMLMFNDNKNDDRPCYFAVEGPYTQMREDNITADDLVFNEDEEPLRYDE---------LLRDISHKARVVYVCCKWETFRKLMVEFWRQGFPQEEYAFFFIDLFGRSLQSHPARPW---ARGDADDNAAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDSLMNLISGSFHDGVMLYSHALNDTMDRSGSRPPGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQIVSVYNGSQKQMILEPGMKVHW--LKGRPPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFIIIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMS-NTEKVLRRAC----------SKLTI------SLRGS--------------------------NYG-------------SLLTMDG-------NFQIYAKTGYYKGNITAIK-YVNKKRIELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDSRFVLKITDYGLESFHKDSNL---DDVHAFYARQLWTAPELLRADNPPACGTQKGDVYSFGIILQELALLKGVFYLEGPC-LSPKEIIERVVEGRWPY-LRP-LLCPQSHSEEMGQLMLRCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEMKGKGRMRTYWLLGE 1061

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 734.561 bits (1895), Expect = 0.000e+0
Identity = 432/1105 (39.10%), Postives = 629/1105 (56.92%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWT-HGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETK--YPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRN-NSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            ++LP++ + +PW  P   PA+  A+ +V + P + P   +       E  D IC E+   L   V       P    GP C Y  +P+    A W +P+++ GA    F +     + ++T  G  H  L  G+     ++ + W  H + ++  T        +  AL G  T+  E  +    +  ++E       ++      L+  I     V  +C  P    ++++   +      EYVF  I +F     ++   PW   A   S++  AK A++S+  +T   P+N+++++F   +K  A R +N+  +  L+N     FYDG++LY HALN++L+D     +G  + K MWN T+ G+ G V ID +GDR  DF++ DM D  TG+F+ VA + GT+    ++P +++ W      +P   P CG+ N       + + +  + + V+  + +I F+   F+YR +KL+ EL A  W I W+ ++ S                                            HL   +    SKL+ +    N+G             SL T  G       N Q+F KT  +KGN+VA+K I ++RR+++ R++L ++K ++D+ N+H+ RFIGAC++     +V +YCP+GSL+++L  + ITLDW+FKYSLI DI +GM +LHN+ +   G LKSSNC+VD+RFVLKITD+GL S+R        ED++ Y+   LW APEL RM   P  GT KGDVYSF I+ QE+  R+GVF L+  D  S +EIV+ V     P   RPSL      +E+   L+++ W E+P  RP+F+ I   +RK N+     +I+      + QYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRPD++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG P KIH+S +T  +L+ F  F +  RG +E+KGKG  +TYWL GE
Sbjct:   52 VILPQHNTSYPWAWPRVGPALDRAIARVNANPNLLPRHRVRHVFANSEDRDGICSESMAPLM-AVDLKFEHNPWAFIGPGCDYTSSPVGLFTAHWGLPMITAGAPAVAFLQ--MEIYTSITNTGPTHKKL--GEYALHLYRHFGWNQHSLLMFSDTKMGERACYF--ALEGLYTEMHEENITTMDL-VFEENKGPVNYSE------LLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPW---ARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPG--GKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMS--------------------------------------------HLEKALRSTGSKLTLSLRGSNYG-------------SLLTTDG-------NFQVFAKTGYFKGNIVAIKYI-NRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESD---TEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPY-LRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNRSVPHYSIV------LSQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 1060

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: npr1b (natriuretic peptide receptor 1b [Source:ZFIN;Acc:ZDB-GENE-100805-4])

HSP 1 Score: 724.546 bits (1869), Expect = 0.000e+0
Identity = 397/886 (44.81%), Postives = 552/886 (62.30%), Query Frame = 3

Query:  909 LCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETK--YPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRN-NSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            +C  P    ++++   +      EYVF  I +F     ++   PW   A   S++  AK A++S+  +T   P+N+++++F   +K  A R +N+  +  L+N     FYDG++LY HALN++L+D     +G  + K MWN T+ G+ G V ID +GDR  DF++ DM D  TG+F+ VA + GT+    ++P +++ W      +P   P CG+ N       + + +  + + V+  + +I F+   F+YR +KL+ EL A  W I W+ ++ S                                            HL   +    SKL+ +    N+G             SL T  G       N Q+F KT  +KGN+VA+K I ++RR+++ R++L ++K ++D+ N+H+ RFIGAC++     +V +YCP+GSL+++L  + ITLDW+FKYSLI DI +GM +LHN+ +   G LKSSNC+VD+RFVLKITD+GL S+R        ED++ Y+   LW APEL RM   P  GT KGDVYSF I+ QE+  R+GVF L+  D  S +EIV+ V     P   RPSL      +E+   L+++ W E+P  RP+F+ I   +RK N+E  S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRPD++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG P KIH+S +T  +L+ F  F +  RG +E+KGKG  +TYWL GE
Sbjct:    4 VCCSPDVFRQLIVHFHKAGLPKEEYVFFYIDIFGHSFRSRPSQPW---ARGDSDDVFAKEAFQSVKILTYLEPQNQEYKDFVTDLKSDAKRMFNFTVDDSLMNIISGGFYDGLMLYCHALNESLSDSHERPSGESVSKRMWNRTYYGVTGLVQIDENGDRETDFALWDMADINTGDFQIVAVYNGTQKEMNILPGMAIQWPG--GKVPMDVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDIQMS--------------------------------------------HLEKALRSTGSKLTLSLRGSNYG-------------SLLTTDG-------NFQVFAKTGYFKGNIVAIKYI-NRRRVELTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMFKYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSIRTESD---TEDAHSYYARKLWLAPELSRMECFPPGGTQKGDVYSFGIILQEVALRRGVFYLEG-DLLSPKEIVDRVALGEWPY-LRPSLNP-QAHSEELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-NILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGE 812

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BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Match: si:dkey-37g12.1 (si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-145])

HSP 1 Score: 655.21 bits (1689), Expect = 0.000e+0
Identity = 406/1034 (39.26%), Postives = 580/1034 (56.09%), Query Frame = 3

Query:  477 VLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIG------LFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHY-EKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
               GP C  V A  A+L AFWNI ++S       F    K  + TLTR+      L  G    +  K++ W H I I +    T  IP+       Y  +   ITV      +Y+++ ++     T+    +++ +     + V+      V  +L++A +    NG++VF          LF S     + W       S +S AK+AY++L  ++L  P +++++ FS+ V   +  ++ Y Y + + ++   +  +D V LYAHALN+TLA+ G   +G  + + MWN T +GI G VTID+SGDR  ++ +  +     + + VA++ GT   +  V  V + W       P   P CG+   +C   ++      I+ G++  L      A   +YR  KL  E + M W I               N N V       H+S V     RS+ L+                                           ASLE+I    +  +Q+     +TA+YKG + ++   ++ R   +N +LL ++K+ +DL + ++C+FIGA LE    +++ +YCPKGSL+D+L  E I LDW FK+SL+ DI +GM YLH++ L   G L SS+C+VDSRFVLK+TDFGL S+R  +    +   +  +  LLW APELLR S P  +GT KGDVYSFAI+ QE+VYR+G F + +   FS +EIVE V+A    +P RP +     C E+   L+   W E P  RPDF+ I+  ++K +  G S NILD+LLSRMEQYA NLE+IV ERT +  EEKK+AE LL  MLP+SVA QLI  + V AE+YD VTI+FSDI GFTA+SA  TPMQ++++LN LYT FD+II+ ++VYKVETIGDAYMV SGLP  NG+ HA+EIARM++A +  +  F  PH P+++L++RIG+HSGP  +GVVGLKMPRYCLFGDTVNT+SRMES GLP KIH+S ST  LL TF  F    RG I +KGKG  +T+WL GE+
Sbjct:   92 AFIGPSCSNVCAVTAKLAAFWNIAVISPVCADQQFLD--KKAYPTLTRVFGPFTKL--GAFFVEICKQFGWQH-IGIIYDGKPTWAIPVEGIK---YQAEHNNITV-----AKYQDIHSSLSQGSTSNWSRVLNEMAQVARIIVISAHGKVVRSLLIEAHKKGLTNGDFVFFCFEPYKQKVLFGS-----FDW---EQGDSYDSMAKQAYQALFFLSLYKPSDKRYQAFSENVISRSKIDFGYTYAQTEKVSVLAAIAHDTVWLYAHALNETLAENGNPYDGLAVTRRMWNRTIKGIQGDVTIDASGDRELNYMMKQIRGSNNQCQVVANYFGT---YKAVKGVQILWPGGLTSPPKDSPDCGFRGELCINLERKF---LIALGIIAGLMAAGTLAICVLYRKYKLPEEASKMLWTI---------------NANDVIMMEH--HSSTVPEKSHRSKPLQ-------------------------------------------ASLESI----ICSMQDKPSAHRTAVYKGTICSVS-FVNLRSTHLNSELLAELKQFRDLTHYNLCKFIGAALETSQPFILTEYCPKGSLQDILQNESIKLDWTFKFSLMLDIVKGMDYLHHSPLQYHGHLSSSSCVVDSRFVLKVTDFGLNSVR--RLDTEQSPGSDPWTALLWRAPELLRQSIPA-NGTQKGDVYSFAIIAQEVVYRRGPFYIPNSH-FSPREIVERVRAGGC-SPSRPYIDRAE-CVEELESLVVSCWRETPAERPDFSYIRTAIKKNSPHGVSENILDDLLSRMEQYACNLEEIVSERTAELQEEKKRAEGLLTQMLPRSVASQLIAGKTVRAETYDCVTIYFSDIEGFTAMSASLTPMQVVNVLNDLYTYFDNIIDYHNVYKVETIGDAYMVVSGLPIRNGDDHAKEIARMSLAIVQGLRSFHSPHVPEQQLRVRIGVHSGPCVAGVVGLKMPRYCLFGDTVNTASRMESYGLPLKIHVSSSTKSLLDTFRNFRCELRGDIHIKGKGWVRTFWLLGED 1027

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 582.022 bits (1499), Expect = 0.000e+0
Identity = 290/502 (57.77%), Postives = 378/502 (75.30%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGK 3518
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RF+GAC++     +V +YCP+GSL+D+L  E I LDW+F+ SLI DI +GM +LH ++ G  G LKSSNC+VDSRFVLKITD+GL S R S +    +D+   +   LWTAPELLRM+ PP  GT KGDVYSF I+ QEI  R G F +   D  S +EIV+ V+    P  FRP++  I   +E+  +L+ + W E+P+ RPDFN IK ++ KFNKEG S +ILDNLLSRMEQYANNLE +V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IHIS +T ++L  F  F +  RG IE+K K
Sbjct:  184 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPY-FRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 677

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Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGK 3518
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RF+GAC++     +V +YCP+GSL+D+L  E I LDW+F+ SLI DI +GM +LH ++ G  G LKSSNC+VDSRFVLKITD+GL S R S +    +D+   +   LWTAPELLRM+ PP  GT KGDVYSF I+ QEI  R G F +   D  S +EIV+ V+    P  FRP++  I   +E+  +L+ + W E+P+ RPDFN IK ++ KFNKEG S +ILDNLLSRMEQYANNLE +V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IHIS +T ++L  F  F +  RG IE+K K
Sbjct:   54 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPY-FRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 547

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 581.637 bits (1498), Expect = 0.000e+0
Identity = 290/502 (57.77%), Postives = 378/502 (75.30%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGK 3518
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RF+GAC++     +V +YCP+GSL+D+L  E I LDW+F+ SLI DI +GM +LH ++ G  G LKSSNC+VDSRFVLKITD+GL S R S +    +D+   +   LWTAPELLRM+ PP  GT KGDVYSF I+ QEI  R G F +   D  S +EIV+ V+    P  FRP++  I   +E+  +L+ + W E+P+ RPDFN IK ++ KFNKEG S +ILDNLLSRMEQYANNLE +V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IHIS +T ++L  F  F +  RG IE+K K
Sbjct:  212 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPY-FRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 705

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 581.252 bits (1497), Expect = 0.000e+0
Identity = 290/502 (57.77%), Postives = 378/502 (75.30%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGK 3518
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RF+GAC++     +V +YCP+GSL+D+L  E I LDW+F+ SLI DI +GM +LH ++ G  G LKSSNC+VDSRFVLKITD+GL S R S +    +D+   +   LWTAPELLRM+ PP  GT KGDVYSF I+ QEI  R G F +   D  S +EIV+ V+    P  FRP++  I   +E+  +L+ + W E+P+ RPDFN IK ++ KFNKEG S +ILDNLLSRMEQYANNLE +V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IHIS +T ++L  F  F +  RG IE+K K
Sbjct:  139 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPY-FRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 632

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BLAST of Guanylate cyclase vs. Ensembl Xenopus
Match: NPR2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100488543])

HSP 1 Score: 580.867 bits (1496), Expect = 0.000e+0
Identity = 290/502 (57.77%), Postives = 378/502 (75.30%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGK 3518
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RF+GAC++     +V +YCP+GSL+D+L  E I LDW+F+ SLI DI +GM +LH ++ G  G LKSSNC+VDSRFVLKITD+GL S R S +    +D+   +   LWTAPELLRM+ PP  GT KGDVYSF I+ QEI  R G F +   D  S +EIV+ V+    P  FRP++  I   +E+  +L+ + W E+P+ RPDFN IK ++ KFNKEG S +ILDNLLSRMEQYANNLE +V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH REIARM++A L A+  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IHIS +T ++L  F  F +  RG IE+K K
Sbjct:  107 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFLGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRNSLINDIVKGMCFLHRSIIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---ADDAYALYAKKLWTAPELLRMTRPPAPGTQKGDVYSFGIILQEIALRNGCFYIQGMD-LSPKEIVQKVRNGQRPY-FRPTVD-ISCHSEELGILMDRCWAEEPLDRPDFNQIKAYICKFNKEG-STSILDNLLSRMEQYANNLEKLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTREIARMSLALLEAVRTFKIRHRPNTQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHISSATKEVLDEFSCFQLELRGDIEMKVK 600

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr1 (natriuretic peptide receptor 1 [Source:MGI Symbol;Acc:MGI:97371])

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 299/514 (58.17%), Postives = 386/514 (75.10%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            Q+F KTA YKGN+VA+K + +++RI++ R++L ++K ++D+ N+H+ RF+GAC +     ++ +YCP+GSL+D+L  E ITLDW+F+YSL  DI +GM++LHN  +G  G LKSSNC+VD RFVLKITD+GL S R  +     E  +  F   LWTAPELLRM++PP  G+  GDVYSF I+ QEI  R GVF ++  D  S +EI+E V     P PFRPS+  +    E+   L+++ W EDP  RP F  I+  +RKFNKE +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LHARE+ARMA+A L A+  F I HRP ++L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IH+S  T  +L+ F  F +  RG +E+KGKG  +TYWL GE 
Sbjct:  547 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD-LSPKEIIERVTRGEQP-PFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051

HSP 2 Score: 229.95 bits (585), Expect = 2.880e-61
Identity = 147/507 (28.99%), Postives = 249/507 (49.11%), Query Frame = 3

Query:  270 LMLPKNFSMFPWPLTI--PAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLT--QEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLF------SSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISF-SAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNL 1748
            ++LP   + +PW      PA+++AL +VK+ P + P   +   L + E    +C +T   L   V       P V  GP C Y  AP+ R  A W +P+L+ GA   G     K E+   TR G  H+ L  G  +    ++  W H   + +     +  P +    G Y+   +   ITV++   +++ E      T        L+  +  K  V  +C  P +   ++L A        +YVF ++ +F      + G   + PW     +  ++ RA++A+++   +T K P+N ++  F  Q+K +A +++N+  E  L N   ++F+DG+LLY  A+ +TLA GG +++G  I + MWN +F+G+ G + ID +GDR  DFS+ DMDP+TG F+ V +F GT    + V    + W       P   P+CG+DN        + +   + A ++G L L+SF    +F+YR ++L+ EL +  W + WE L+ S   R+L
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGV--KDEYALTTRTGPSHVKL--GDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNH---QEFVEGDPDHYTK-------LLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLA-LVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHL 520

[Close]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 590.882 bits (1522), Expect = 0.000e+0
Identity = 294/515 (57.09%), Postives = 380/515 (73.79%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSFAI+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T   L   G F +  RG +E+KGKG  +TYWL GE +
Sbjct:  101 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQK 607

[Close]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0
Identity = 294/515 (57.09%), Postives = 380/515 (73.79%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSFAI+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T   L   G F +  RG +E+KGKG  +TYWL GE +
Sbjct:  535 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQK 1041

HSP 2 Score: 188.734 bits (478), Expect = 3.287e-48
Identity = 140/501 (27.94%), Postives = 227/501 (45.31%), Query Frame = 3

Query:  261 LAMLMLPKNFS-MFPWPLTIPAIKIALEKV-KSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY-LTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPK-PDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            LA+++   N S  + WP   PA+ +A+E + +++P     V S      +D  C E   A  R V   +   PD+L GP C Y  A +AR  + W +P+L+ GAV  GF   +   ++TL R G     L  G+ +      + WT    + +  A T+  P Y    G +   Q   ++V +           A            I A G    +  +C     +H ILL+A + N  NG+YVF  + +F           T  PW      Q +    + A++++L +T + P N +++ F +++   A  ++       L+N     FYDG+LLYA  LN+T+ +GG   +G  I++ M    + G+ G V +D + DR  DF +  M D  +G+F+P AH+ G +          + W  V    P   P C +  D+  C K P   L I A+  GV   +F +S    + ++R + L+ EL +M W I WE L+
Sbjct:   27 LAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSS-----ELDGACSEY-LAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF-AAKNEHYRTLVRTGPSAPKL--GEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH--------QVYAREPGGPEQATHFIRANGR---IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQ-DNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWT-GRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVS---SFLIFRKLMLEKELASMLWRIRWEELQ 500

[Close]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Npr2 (natriuretic peptide receptor 2 [Source:MGI Symbol;Acc:MGI:97372])

HSP 1 Score: 483.411 bits (1243), Expect = 1.606e-151
Identity = 244/437 (55.84%), Postives = 321/437 (73.46%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSG 3323
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSFAI+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+G
Sbjct:  535 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTG 963

HSP 2 Score: 188.734 bits (478), Expect = 3.301e-48
Identity = 140/501 (27.94%), Postives = 227/501 (45.31%), Query Frame = 3

Query:  261 LAMLMLPKNFS-MFPWPLTIPAIKIALEKV-KSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY-LTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPK-PDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            LA+++   N S  + WP   PA+ +A+E + +++P     V S      +D  C E   A  R V   +   PD+L GP C Y  A +AR  + W +P+L+ GAV  GF   +   ++TL R G     L  G+ +      + WT    + +  A T+  P Y    G +   Q   ++V +           A            I A G    +  +C     +H ILL+A + N  NG+YVF  + +F           T  PW      Q +    + A++++L +T + P N +++ F +++   A  ++       L+N     FYDG+LLYA  LN+T+ +GG   +G  I++ M    + G+ G V +D + DR  DF +  M D  +G+F+P AH+ G +          + W  V    P   P C +  D+  C K P   L I A+  GV   +F +S    + ++R + L+ EL +M W I WE L+
Sbjct:   27 LAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSS-----ELDGACSEY-LAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF-AAKNEHYRTLVRTGPSAPKL--GEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH--------QVYAREPGGPEQATHFIRANGR---IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQ-DNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWT-GRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVS---SFLIFRKLMLEKELASMLWRIRWEELQ 500

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BLAST of Guanylate cyclase vs. Ensembl Mouse
Match: Gucy2g (guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:106025])

HSP 1 Score: 463.766 bits (1192), Expect = 1.516e-143
Identity = 349/1075 (32.47%), Postives = 526/1075 (48.93%), Query Frame = 3

Query:  477 VLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTH-GIY--IYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVA---VLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYH------YEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNM--WNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGE--FKPVAHFIGTKSSFLVVPNVSVDWGSVSNV------IPSTKPRCGYDNSMC---PKPDKNLNIGAISAGVMGCLFLISFSA----GYFVYR-NIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLF-TKTALYKGNVVALKPILSQ-----RRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRK--GVFSLDSED-DFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPK 3581
             LFGP C      I  L + WNIP+      + G     K  F   T +        +  +++++ +   W H G++      +++  V  ++     G L   F IT       +Y   +             L + + N   VA   +L        RIL  A  L  + GE+VFI   L     ++ +   LT   + +  R  + Y S   V L  P         D  ++  S+E            +D ++ + +  +D +LLYA  + +         +G  +I  +     T +GI G V +DS G R  D+S+  +        F P  H+     SF     V   W + SN       +P  KP CG+ N +C   P     + +  ++A +    FL+  SA    G  ++R   K+Q+      W I ++S+        L+  + + ++  P+    V    S +  +K + +                                      C SL       + + Q+ +LF     LY+GN VAL  I  +     ++  + R++ +      +L +++I  F G C E     +V  YC KGSL+DV+      +DW+FK S   DI  G+++LH + L   G LK SNCLVDS   LK++ FGL   +    +            L WTAPELLR+   P  GT +GDVYSFAI+ +++++++  G F    ED + + +EI+  +K   +P P RPSL    G     V L+++ W+E P LRP F +IK  +R+ +  G   +ILD+++ ++E YAN+LE++V+ERT + + EK+K E LL +MLP  V  QLI  + V  E ++ VTIFFSDIVGFT L + S+P+Q++ LLN LY+ FD  I+++DVYKVETIGDAYMV SGLP  NG  HA EIA MA+  LS    F I H P++ LKLRIG+H+GPV +GVVG+ MPRYCLFGDTVN +SRMES+ LP +IH+SQST   L   G + + +RG I VKGKG   T+WL G++   V P+P+
Sbjct:  117 ALFGPACPEAAEVIGLLASEWNIPLFD----FVGQMAALKDHFWCDTCVTLVPPKQEISAVLRESLRYLGWEHIGVFGGSSADSSWEQVDEMWGAVEDG-LQFHFNITASM----RYNSSS----------SDLLQEGLRNMSYVARVIILICSSEDARRILQAAVDLGLDTGEFVFI---LLQQLEDSFWKEVLT---KDKVIRFPKVYES---VFLIAPSAYGGGIGDDGFRKQVSQELRRPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRKAEKDFRDGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQESGNRSLFLPFLHY----DSF---QKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKPPTVAGMTV-TVTAVIPTVTFLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSI-------TLLPQHKLSHRGTPVSRRNV----SDTSTVKASAD--------------------------------------CGSL-------VKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMC----ELKHENIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSHGNLKPSNCLVDSHMQLKLSGFGLWEFKHGSTWRSYNQEATDHSELYWTAPELLRLRESPCSGTPQGDVYSFAILLRDLIHQQAHGPF----EDLEAAPEEIISRIKDPRAPVPLRPSLLEDKG-DGRIVALVRECWDESPELRPIFPSIKKTLREASPRGHV-SILDSMMGKLETYANHLEEVVEERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQVVKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIGHMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAAGGYHLQKRGTISVKGKGEQTTFWLKGKDGFPV-PLPE 1088

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16066|ANPRA_HUMAN (Atrial natriuretic peptide receptor 1 OS=Homo sapiens OX=9606 GN=NPR1 PE=1 SV=1)

HSP 1 Score: 610.527 bits (1573), Expect = 0.000e+0
Identity = 303/516 (58.72%), Postives = 389/516 (75.39%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            Q+F KTA YKGN+VA+K + +++RI++ R++L ++K ++D+ N+H+ RF+GAC +     ++ +YCP+GSL+D+L  E ITLDW+F+YSL  DI +GM++LHN  G I   G LKSSNC+VD RFVLKITD+GL S R     L  E  +  +   LWTAPELLRM++PP+ G+  GDVYSF I+ QEI  R GVF ++  D  S +EI+E V     P PFRPSL A+    E+  LL+++ W EDP  RP F  I+  +RKFN+E +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LHA E+ARMA+A L A+  F I HRP ++L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S  T  +L+ FG F +  RG +E+KGKG  +TYWL GE 
Sbjct:  551 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHN--GAICSHGNLKSSNCVVDGRFVLKITDYGLESFRD----LDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLD-LSPKEIIERVTRGEQP-PFRPSL-ALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGER 1055

HSP 2 Score: 220.705 bits (561), Expect = 1.748e-57
Identity = 146/508 (28.74%), Postives = 242/508 (47.64%), Query Frame = 3

Query:  270 LMLPKNFSMFPWPLTI--PAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYC----HALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSS------GNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNL 1748
            ++LP   + +PW      PA+++AL +VK+ P + P   +   L + E    +C +T   L   V       P V  GP C Y  AP+ R  A W +P+L+ GA   GF    K E+   TR G  +  L  G  +    ++  W     + +  AY      +C      L   +     ITVD+    ++ E   +  T        L+  +  K  V  +C  P +   ++L A +      +YVF ++ +F        G   + PW        ++  A++A+++   +T K P+N ++  F  Q+K +A  ++N+  E  L+NT  ++F+DG+LLY  A+ +TLA GG +++G  I + MWN +F+G+ G + IDSSGDR  DFS+ DMDP+ G F+ V ++ GT    + V    ++W       P   P+CG+DN        +L+   + A V     L      +F+YR ++L+ EL +  W + WE +E S   R+L
Sbjct:   39 VVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLA-AVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGV--KDEYALTTRAGPSYAKL--GDFVAALHRRLGWERQALMLY--AYRPGDEEHCFFLVEGLFMRVRDRLNITVDHL---EFAEDDLSHYTR-------LLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPW---ERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHL 524

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18293|ANPRA_MOUSE (Atrial natriuretic peptide receptor 1 OS=Mus musculus OX=10090 GN=Npr1 PE=1 SV=2)

HSP 1 Score: 610.142 bits (1572), Expect = 0.000e+0
Identity = 299/514 (58.17%), Postives = 386/514 (75.10%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            Q+F KTA YKGN+VA+K + +++RI++ R++L ++K ++D+ N+H+ RF+GAC +     ++ +YCP+GSL+D+L  E ITLDW+F+YSL  DI +GM++LHN  +G  G LKSSNC+VD RFVLKITD+GL S R  +     E  +  F   LWTAPELLRM++PP  G+  GDVYSF I+ QEI  R GVF ++  D  S +EI+E V     P PFRPS+  +    E+   L+++ W EDP  RP F  I+  +RKFNKE +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LHARE+ARMA+A L A+  F I HRP ++L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   +IH+S  T  +L+ F  F +  RG +E+KGKG  +TYWL GE 
Sbjct:  547 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD-LSPKEIIERVTRGEQP-PFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051

HSP 2 Score: 229.95 bits (585), Expect = 2.015e-60
Identity = 147/507 (28.99%), Postives = 249/507 (49.11%), Query Frame = 3

Query:  270 LMLPKNFSMFPWPLTI--PAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLT--QEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLF------SSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISF-SAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNL 1748
            ++LP   + +PW      PA+++AL +VK+ P + P   +   L + E    +C +T   L   V       P V  GP C Y  AP+ R  A W +P+L+ GA   G     K E+   TR G  H+ L  G  +    ++  W H   + +     +  P +    G Y+   +   ITV++   +++ E      T        L+  +  K  V  +C  P +   ++L A        +YVF ++ +F      + G   + PW     +  ++ RA++A+++   +T K P+N ++  F  Q+K +A +++N+  E  L N   ++F+DG+LLY  A+ +TLA GG +++G  I + MWN +F+G+ G + ID +GDR  DFS+ DMDP+TG F+ V +F GT    + V    + W       P   P+CG+DN        + +   + A ++G L L+SF    +F+YR ++L+ EL +  W + WE L+ S   R+L
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGV--KDEYALTTRTGPSHVKL--GDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNH---QEFVEGDPDHYTK-------LLRTVQRKGRVIYICSSPDAFRNLMLLALDAGLTGEDYVFFHLDVFGQSLQGAQGPVPRKPW---ERDDGQDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTMEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNFNGTSQELMAVSEHRLYW--PLGYPPPDIPKCGFDNEDPACNQDHFSTLEVLA-LVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHL 520

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P18910|ANPRA_RAT (Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus OX=10116 GN=Npr1 PE=1 SV=1)

HSP 1 Score: 607.446 bits (1565), Expect = 0.000e+0
Identity = 301/516 (58.33%), Postives = 386/516 (74.81%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            Q+F KTA YKGN+VA+K + +++RI++ R++L ++K ++D+ N+H+ RF+GAC +     ++ +YCP+GSL+D+L  E ITLDW+F+YSL  DI +GM++LHN  G I   G LKSSNC+VD RFVLKITD+GL S R  +     E  +  F   LWTAPELLRM++PP  G+  GDVYSF I+ QEI  R GVF ++  D  S +EI+E V     P PFRPS+  +    E+   L+++ W EDP  RP F  I+  +RKFNKE +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LHARE+ARMA+A L A+  F I HRP ++L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S  T  +L+ F  F +  RG +E+KGKG  +TYWL GE 
Sbjct:  547 QVFAKTAYYKGNLVAVKRV-NRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHN--GAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPE----PEQGHTLFAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLD-LSPKEIIERVTRGEQP-PFRPSMD-LQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKE-NSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFDGFELELRGDVEMKGKGKVRTYWLLGER 1051

HSP 2 Score: 226.483 bits (576), Expect = 2.961e-59
Identity = 146/507 (28.80%), Postives = 247/507 (48.72%), Query Frame = 3

Query:  270 LMLPKNFSMFPWPLTI--PAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLT--QEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLF------SSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISF-SAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNL 1748
            ++LP   + +PW      PA+++AL +VK+ P + P   +   L + E    +C +T   L   V       P V  GP C Y  AP+ R  A W +P+L+ GA   G     K E+   TR G  H+ L  G  +    ++  W H   + +     +  P +    G Y+   +   ITV++   +++ E               L+ A+  K  V  +C  P +   ++L A        +YVF ++ +F      + G   + PW        ++  A++A+++   +T K P+N ++  F  Q+K +A +++N+  E  L N   ++F+DG+LLY  A+ +TLA GG +++G  I + MWN +F+G+ G + ID +GDR  DFS+ DMDP+TG F+ V ++ GT    + V    + W       P   P+CG+DN        + +   + A ++G L LISF    +F+YR ++L+ EL +  W + WE L+ S   R+L
Sbjct:   35 VVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVLGSSENAAGVCSDTAAPLA-AVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHWRVPLLTAGAPALGIGV--KDEYALTTRTGPSHVKL--GDFVTALHRRLGWEHQALVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNH---QEFVEGDPDHYPK-------LLRAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKSAQGLVPQKPW---ERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQRMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQELMAVSEHKLYW--PLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLA-LVGSLSLISFLIVSFFIYRKMQLEKELVSELWRVRWEDLQPSSLERHL 520

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BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|P16067|ANPRB_RAT (Atrial natriuretic peptide receptor 2 OS=Rattus norvegicus OX=10116 GN=Npr2 PE=1 SV=1)

HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0
Identity = 294/515 (57.09%), Postives = 380/515 (73.79%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSFAI+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T   L   G F +  RG +E+KGKG  +TYWL GE +
Sbjct:  535 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERK 1041

HSP 2 Score: 189.119 bits (479), Expect = 2.071e-47
Identity = 138/501 (27.54%), Postives = 228/501 (45.51%), Query Frame = 3

Query:  261 LAMLMLPKNFS-MFPWPLTIPAIKIALEKV-KSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY-LTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPK-PDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            LA+++   N S  + WP   PA+ +A+E + +++P     V S      +D  C E   A  R V   +   PD+L GP C Y  A +AR  + W++P+L+ GAV  GF   +   ++TL R G     L  G+ +      + WT    + +  A T+  P Y    G +   Q   ++V +                        I A G    +  +C     +H ILL+A + N  NG+YVF  + +F           T  PW      Q +    + A++++L +T + P N +++ F +++   A  ++       L+N     FYDG+LLYA  LN+T+ +GG   +G  I++ M    + G+ G V +D + DR  DF +  M D ++G+F+P AH+ G +          + W  V    P   P C +  D+  C K P   L I A+  G+   +F +S    + ++R + L+ EL +M W I WE L+
Sbjct:   27 LAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSS-----ELDGACSEY-LAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWHLPLLTAGAVASGF-AAKNEHYRTLVRTGPSAPKL--GEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH--------QVYTREPGGPEQATHFIRANGR---IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQ-DNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWT-GRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVS---SFLIFRKLMLEKELASMLWRIRWEELQ 500

[Close]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Match: sp|Q6VVW5|ANPRB_MOUSE (Atrial natriuretic peptide receptor 2 OS=Mus musculus OX=10090 GN=Npr2 PE=1 SV=2)

HSP 1 Score: 590.497 bits (1521), Expect = 0.000e+0
Identity = 294/515 (57.09%), Postives = 380/515 (73.79%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNL-GPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            Q+F  T  +KGNVVA+K + +++RI++ RQ+L ++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  + I LDW+F+YSLI D+ +GM +LHN++    G+LKSSNC+VDSRFVLKITD+GL S R + +    +DS+  +   LWTAPELL  +  P  G  K DVYSFAI+ QEI  R G F L+  D  S +EIV+ V+    P  FRPS+       E+ VLL+++ W +DP  RPDF  IK  +R+FNKEG + +ILDNLL RMEQYANNLE +V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA EIARMA+A L A+  F I HRP  +L+LRIG+H+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T   L   G F +  RG +E+KGKG  +TYWL GE +
Sbjct:  535 QIFANTGHFKGNVVAIKHV-NKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAE---PDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLD-LSPKEIVQKVRNGQRPY-FRPSIDRTQ-LNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGEQK 1041

HSP 2 Score: 188.734 bits (478), Expect = 2.299e-47
Identity = 140/501 (27.94%), Postives = 227/501 (45.31%), Query Frame = 3

Query:  261 LAMLMLPKNFS-MFPWPLTIPAIKIALEKV-KSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY-LTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPK-PDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            LA+++   N S  + WP   PA+ +A+E + +++P     V S      +D  C E   A  R V   +   PD+L GP C Y  A +AR  + W +P+L+ GAV  GF   +   ++TL R G     L  G+ +      + WT    + +  A T+  P Y    G +   Q   ++V +           A            I A G    +  +C     +H ILL+A + N  NG+YVF  + +F           T  PW      Q +    + A++++L +T + P N +++ F +++   A  ++       L+N     FYDG+LLYA  LN+T+ +GG   +G  I++ M    + G+ G V +D + DR  DF +  M D  +G+F+P AH+ G +          + W  V    P   P C +  D+  C K P   L I A+  GV   +F +S    + ++R + L+ EL +M W I WE L+
Sbjct:   27 LAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSS-----ELDGACSEY-LAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGF-AAKNEHYRTLVRTGPSAPKL--GEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQH--------QVYAREPGGPEQATHFIRANGR---IVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQ-DNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLDSGDFQPAAHYSGAEKQIWWT-GRPIPW--VKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGVTFIMFGVS---SFLIFRKLMLEKELASMLWRIRWEELQ 500

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BLAST of Guanylate cyclase vs. TrEMBL
Match: G4V651 (Guanylate cyclase OS=Schistosoma mansoni OX=6183 GN=Smp_142620 PE=3 SV=1)

HSP 1 Score: 1000.35 bits (2585), Expect = 0.000e+0
Identity = 542/1117 (48.52%), Postives = 706/1117 (63.21%), Query Frame = 3

Query:  315 IPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMP----DVLFGPICGYVLAPIARL-LAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDL--VLGQMIQKTFKKYKW------------THGIYIYHKT-AYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTF------KGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDA 3587
            +PAI +ALE ++S P    +           ++ +    AL       +TQ+     +V+FGP+  + LA  AR   A +N+PI++     +  +   K E+  LTR+   + DL  V G     T K Y W            T  +        +T +  ++ H     + Q+F +         YK L+          ++FL   + +   + +LC DP  V  I+L+A +LN  NG+Y F N+ L SS  + K PWY   S+  EN RA++AYR+L++VTL  P++ ++R F+++V+  A R+Y++ Y    +  F+  F+D V LYA ALN  LA GG I+NG+LI + MWN TF+G+ G V ID++GDR AD+S+LDM+P TG+F+ V ++ G   S   V   ++DW +  N  P   P CG+D S C      ++IG + A V   L  +S   G   YR  K QAEL AMNWIIPW++L+ +EK                              +L+  R E        ++  P+            +P+ K    IS  +    A        N+Q+F +TA Y  ++VALKP+  Q R++ ++ L I+VKKVKDLN DHICR IG CLE+ +Q +VY+YCPKGSL+DVL  EQI LDW+FK+SL+QDICRG++YLH   GP G LKSSNCLVDSRFVLKITDFGL  +RG      E  S ++ +NLLWTAPELL    P  D T       KGDVYSFAIVCQEIVYRKGVF + +  +     IV+ VKA   P PFRP+L ++ GC+ED V LI Q+W++DP +RPDF +IK  MRK NK GDS N+LDNLLSRMEQYANNLE++V++RT QYLEEKKK EDLLYSMLP+SVA QL +NQPV AES+++VTI+FSDIVGFT+LSAESTPMQ+++LLNRLYT FD IIEN+D YKVETIGDAYMV SGLPQ NGN HARE+ARM+IAFL AIF F IPHRP+K L+LRIGIHSGPVC+GVVG KMPRYCLFGDTVNTSSRMESNGLP KIHISQ T  +LKTF +F+MTERG +E+KGKG  +TYWLHGE+  IVDPIP  A
Sbjct:   97 LPAIDLALEDIQSFPAFGGVS--------FTTVLILYIDALACDALALLTQLNSNGVNVIFGPLNDFTLANAARFSTAMYNVPIVAPAG--FAHQLSDKLEYGMLTRVLFTYSDLEWVFGN----TLKHYGWLPDQQTPIAIVTTRNVRRREGVVGHTGMAGVFQH----LILQKFLVKA------AYKLLSVTLDDEFDVTDRFL-KRLPDSARIIILCTDPEVVRDIMLEAHKLNMVNGDYAFFNMDLLSSQTKLKRPWYRETSSPEENERARQAYRALMTVTLLKPDSPEYRTFTEEVRARALRDYDFSYRDSEVTPFIGTFHDAVKLYALALNDALAKGGTITNGTLITQEMWNRTFKGVTGVVRIDANGDRNADYSLLDMNPVTGDFEVVVNYFGNDKSLSTVLGRTIDWINTDNQPPLHTPPCGFDGSECHN-SHFIHIGIVGAVVFILLMTMSLVLGIIFYRRAKFQAELRAMNWIIPWDALQVTEK------------------------------HLRRYRRE-------SDIRSPNQS---------SDPLRK----ISSETCTAAAA-------NSQMFARTAFYMKSIVALKPLRRQTRMEPSKALSIEVKKVKDLNCDHICRLIGVCLEVPHQCIVYEYCPKGSLQDVLENEQIKLDWMFKFSLMQDICRGVMYLHQIFGPHGNLKSSNCLVDSRFVLKITDFGLPHIRGPPPLESEVGSFIFHRNLLWTAPELL----PDGDTTIYPRESIKGDVYSFAIVCQEIVYRKGVFYIQNFKNCEPDFIVKEVKAHRKP-PFRPTLDSLEGCSEDLVQLICQAWDDDPSVRPDFQSIKLSMRKLNKAGDSNNVLDNLLSRMEQYANNLEELVEQRTAQYLEEKKKTEDLLYSMLPRSVAKQLFRNQPVTAESFEMVTIYFSDIVGFTSLSAESTPMQVVELLNRLYTLFDGIIENFDAYKVETIGDAYMVASGLPQRNGNKHAREVARMSIAFLKAIFEFQIPHRPEKRLELRIGIHSGPVCAGVVGQKMPRYCLFGDTVNTSSRMESNGLPLKIHISQQTFDVLKTFKSFIMTERGLVEMKGKGRQKTYWLHGEDCYIVDPIPPGA 1125

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A1I8HCY1 (Guanylate cyclase OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 952.584 bits (2461), Expect = 0.000e+0
Identity = 527/1133 (46.51%), Postives = 715/1133 (63.11%), Query Frame = 3

Query:  315 IPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARL--LAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKW----THGIY--------IYHKTAYTNV----IPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGG--AISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE----------TSEKIRNLVNHNCVKYQSKPI--HNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIY-KDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMY-FKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTA-----IHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFL 3593
            +P + IA+E V ++  ++    SL      DS C + + A   GV   + Q  D++ GP C + LA +AR   +  +  PIL+TG V    R   K+E+  L R+G    D V  +M+   F+++ W       I         +  K     +      + CH +  +  QE  I          + L           E F +  + ++  + VLC DP +V  I++KA +L F NGEYVF NI LFSS   T  PW         N +A RAYR+L+++TL+ P + ++RNFS QVK +A  +YN+ Y ++ +N+FV  F+D V+LYA A+N T+ + G   I+NGSLI + M N TFEGI GTV+I+++GDR AD+S+LDMD  T  F  VAH+ G +  + +VP   +DW +  N+ P   P+CG+D SMC +    +   A+   ++    L    A   +YR ++L++EL+AMNW IPW  LE          TSE  ++L   +    QS+P   H  + + HQ R+ +++       N       E  +SK +R+  K+  +       + +S  S++TIAG+ L +I   QLFTKTA YKG +VALKP+ L  +RI++  +LL++VK+VKDL +D++ RFIGACL+   + +V +YCPKGSL+DVL  + + LDW+FK+SL+ DICRGM+YLH+N G  G LKSSNCLVDSRF LKI DFGL SLRG+K Y  +ED+    ++N LWTAPELLR   PP +GT +GDVYSFAI+CQEI+YR+GVF +   D    QEIVE VK E S   +RP+L A         +E  +  ++  W EDP  RP FN+IK  + +FNK+ +SGNILDNLL RMEQY+NNLE +V +RT+ YLEEKKKAE+LLY MLPKSVA  L++ + V AE +D VTI+FSDI GFTALS+ESTP++++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NG LHAREI+RMA++FL  I+ F I H+PD +LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIHIS  T ++L+  G F+ T RG +E+KGKG   TYWLHGE + IVDP+  +  L
Sbjct:    7 LPVVDIAIETVTTLDLLHGHSVSLIA---NDSKC-DYSVAPVLGV-LLLQQKIDLMLGPYCSFALAAVARYNRMPHYRRPILTTGGVASALRD--KAEYFNLIRVGPS-FDGV-EKMLYLVFQRFNWKPRDVQTILFIELPDEDVKEKRTRDEIGVTQSRILCHGIEKHFVQEKYIV---------RRLQYEMHNAQFKSEIFRV--MRDEIRLVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIA--VIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHN-------EGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRNKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVK-EISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSL 1109

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267GXV3 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000254g3 PE=3 SV=1)

HSP 1 Score: 939.102 bits (2426), Expect = 0.000e+0
Identity = 484/936 (51.71%), Postives = 639/936 (68.27%), Query Frame = 3

Query:  864 QFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGG--AISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE----------TSEKIRNLVNHNCVKYQSKPI--HNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIY-KDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN-----MYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTA-----IHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFL 3593
            + L++ +GNK AV VLC DP +V  I++KA +L F NGEYVF NI LFSS   T  PW         N +A RAYR+L+++TL+ P + ++RNFS QVK +A  +YN+ Y ++ +N+FV  F+D V+LYA A+N T+ + G   I+NGSLI + M N TFEGI GTV+I+++GDR AD+S+LDMD  T  F  VAH+ G +  + +VP   +DW +  N+ P   P+CG+D SMC +    +   A+   ++    L    A   +YR ++L++EL+AMNW IPW  LE          TSE  ++L   +    QS+P   H  + + HQ R+ +++       N       E  +SK +R+  K+  +       + +S  S++TIAG+ L +I   QLFTKTA YKG +VALKP+ L  +RI++  +LL++VK+VKDL +D++ RFIGACL+   + +V +YCPKGSL+DVL  + + LDW+FK+SL+ DICRGM+YLH+N G  G LKSSNCLVDSRF LKI DFGL SLRG+K Y  +ED+        F + LWTAPELLR   PP +GT +GDVYSFAI+CQEI+YR+GVF +   D    QEIVE VK E S   +RP+L A         +E  +  ++  W EDP  RP FN+IK  + +FNK+ +SGNILDNLL RMEQY+NNLE +V +RT+ YLEEKKKAE+LLY MLPKSVA  L++ + V AE +D VTI+FSDI GFTALS+ESTP++++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NG LHAREI+RMA++FL  I+ F I H+PD +LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIHIS  T ++L+  G F+ T RG +E+KGKG   TYWLHGE + IVDP+  +  L
Sbjct:  245 KILLERVGNKLAVVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIA--VIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHN-------EGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRRQFYDKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVK-EISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSL 1170

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267GHM2 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig024971g2 PE=3 SV=1)

HSP 1 Score: 936.021 bits (2418), Expect = 0.000e+0
Identity = 483/936 (51.60%), Postives = 639/936 (68.27%), Query Frame = 3

Query:  864 QFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGG--AISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE----------TSEKIRNLVNHNCVKYQSKPI--HNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIY-KDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN-----MYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTA-----IHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFL 3593
            + L++ +GNK AV VLC DP +V  I++KA +L F NGEYVF NI LFSS   T  PW         N +A RAYR+L+++TL+ P + ++RNFS QVK +A  +YN+ Y ++ +N+FV  F+D V+LYA A+N T+ + G   I+NGSLI + M N TFEGI GTV+I+++GDR AD+S+LDMD  T  F  VAH+ G +  + +VP   +DW +  N+ P   P+CG+D SMC +    +   A+   ++    L    A   +YR ++L++EL+AMNW IPW  LE          TSE  ++L   +    QS+P   H  + + HQ R+ +++       N       E  +SK +R+  K+  +       + +S  S++TIAG+ L +I   QLFTKTA YKG +VALKP+ L  +RI++  +LL++VK+VKDL +D++ RFIGACL+   + +V +YCPKGSL+DVL  + + LDW+FK+SL+ DICRGM+YLH+N G  G LKSSNCLVDSRF LKI DFGL SLRG+K Y  +ED+        F + LWTAPELLR   PP +GT +GDVYSFAI+CQEI+YR+GVF +   D    QEIVE VK E S   +RP+L A         +E  +  ++  W EDP  RP FN+IK  + +FNK+ +SGNILDNLL RMEQY+NNLE +V +RT+ YLEEKKKAE+LLY MLPKSVA  L++ + V AE +D VTI+FSDI GFTALS+ESTP++++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NG LHAREI+RMA++FL  I+ F I H+PD +LKLRIGI+SGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIHIS  T ++L+  G F+ T RG +E+KGKG   TYWLHGE + IVDP+  +  L
Sbjct:  245 KILLERVGNKLAVVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIA--VIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSQPHRHHQHRGQSHQKRTDSVRILFGNSHN-------EGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRRQFYDKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVK-EISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGINSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYWLHGEGDSIVDPVVSNGSL 1170

[Close]

BLAST of Guanylate cyclase vs. TrEMBL
Match: A0A267EU15 (Guanylate cyclase OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig000254g5 PE=3 SV=1)

HSP 1 Score: 934.095 bits (2413), Expect = 0.000e+0
Identity = 483/936 (51.60%), Postives = 638/936 (68.16%), Query Frame = 3

Query:  864 QFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGG--AISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE----------TSEKIRNLVNHNCVKYQSKPI--HNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIY-KDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPI-LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN-----MYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTA-----IHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFL 3593
            + L++ +GNK AV VLC DP +V  I++KA +L F NGEYVF NI LFSS   T  PW         N +A RAYR+L+++TL+ P + ++RNFS QVK +A  +YN+ Y ++ +N+FV  F+D V+LYA A+N T+ + G   I+NGSLI + M N TFEGI GTV+I+++GDR AD+S+LDMD  T  F  VAH+ G +  + +VP   +DW +  N+ P   P+CG+D SMC +    +   A+   ++    L    A   +YR ++L++EL+AMNW IPW  LE          TSE  ++L   +    QS+P   H  + + HQ R+ +++       N       E  +SK +R+  K+  +       + +S  S++TIAG+ L +I   QLFTKTA YKG +VALKP+ L  +RI++  +LL++VK+VKDL +D++ RFIGACL+   + +V +YCPKGSL+DVL  + + LDW+FK+SL+ DICRGM+YLH+N G  G LKSSNCLVDSRF LKI DFGL SLRG+K Y  +ED+        F + LWTAPELLR   PP +GT +GDVYSFAI+CQEI+YR+GVF +   D    QEIVE VK E S   +RP+L A         +E  +  ++  W EDP  RP FN+IK  + +FNK+ +SGNILDNLL RMEQY+NNLE +V +RT+ YLEEKKKAE+LLY MLPKSVA  L++ + V AE +D VTI+FSDI GFTALS+ESTP++++ LLN LYT FD IIE YD YKVETIGDAYMV SGLP  NG LHAREI+RMA++FL  I+ F I H+PD +LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIHIS  T ++L+  G F+ T RG +E+KGKG   TY LHGE + IVDP+  +  L
Sbjct:  245 KILLERVGNKLAVVVLCADPDTVREIMIKAQELGFINGEYVFFNIDLFSSEKLTLQPWRRENDTHERNEKAARAYRALMTITLRKPSSPEYRNFSQQVKSIAKSKYNFTYPEEEVNSFVGAFHDAVILYALAINDTVYEHGFEGIANGSLITEKMKNRTFEGITGTVSINANGDRDADYSLLDMDKNTRNFVVVAHYYGNRQKYELVPGKEIDWYNEDNLPPRDIPKCGFDYSMCKQDLSKVATYAVVVLLVLICVLSVVIA--VIYRKLRLESELHAMNWRIPWSELEPMERIAAGRRTSESGKDLQQQDEEPEQSRPHRHHQHRGQSHQKRTDSVRILFGNSHN-------EGSTSKKNRDEKKHQNDQHSGAAAEEMSLVSVDTIAGVPLSQIPVTQLFTKTAYYKGALVALKPLSLRNKRIEVTNKLLMEVKRVKDLTSDNVIRFIGACLDAPNECLVSEYCPKGSLQDVLENDNLNLDWMFKFSLMLDICRGMIYLHHNFGSHGNLKSSNCLVDSRFSLKIADFGLQSLRGTKDYKDKEDAEYSSYRRQFYDKLWTAPELLRNPTPPPEGTKEGDVYSFAIICQEIIYRRGVFFISDYDFPEPQEIVEKVK-EISNQMYRPTLDAETNDPDQERSEALINTVRNCWQEDPAARPSFNSIKSRISRFNKDAESGNILDNLLKRMEQYSNNLESLVAKRTDLYLEEKKKAENLLYCMLPKSVATTLLRGESVTAEWFDSVTIYFSDICGFTALSSESTPLEVVTLLNDLYTLFDRIIEQYDCYKVETIGDAYMVVSGLPMRNGILHAREISRMALSFLQNIYSFKIRHKPDVQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHISSFTHEILEEIGGFVTTARGEVEMKGKGKQLTYCLHGEGDSIVDPVVSNGSL 1170

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 657.522 bits (1695), Expect = 0.000e+0
Identity = 398/1030 (38.64%), Postives = 581/1030 (56.41%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQ--YKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETK--YPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSR-SQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSG 3323
            ++LPK  + +PW  P   PA+  ALEKV S P + P   +     + E  + +C ++   L   V       P    GP C Y  +P+AR    W +P+++ GA   GF     + + ++T  G  H  L  G+ + +    + W     +       +  P Y    G Y     E+T D    +   + E        D      LI+ I  +  V  +C    +  +++++  +      EYVF  I LF     ++   PW   A   +++  AK+A++S+  +T + P+N ++++F  ++K  A +E+N+  E  L+N     F+DGVLLY+HALN+++   G    G ++ K MWN TF G+ G V +D +GDR  DF++ DM D ++G ++ V+ +  +    ++ P + V W  +    P   P CG+ N       K + +  + + V   +F+I  +   F+YR +KL+ EL A  W + WE ++    I NL              +  ++   SR + +L+G+                          N+G             SL T+ G       N Q++ KT  YKGN+ A+K  ++++RI++ R++L ++K ++D+ N+H+ RFIGAC++     ++ +YCP+GSL+D++  E ITLDW+F+YSLI DI +GM +LHN+ +   G LKSSNCLVDSRFVLKITD+GL S R  + YL  ED++ Y+   LWTAPEL+R  N    GT KGDVYSF I+ QE+   KGVF LDS   FS +EIVE V AE      RP L      +E+   L+++ W+ED   RPDFN IK  + K N  G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTA+SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH  EIARM++A L A++ F I HRPD +L+LRIGIH+G
Sbjct:   52 IILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLV-AVDLKFAHDPWAFIGPGCDYASSPVARFTTHWEVPMVTAGAPALGF-----NMYSSITNTGPTHKKL--GEFVVRMHHNFGWHKYAMVMFHDKKNDDRPCYFAVEGPYT----EMTADNITAKDMVFNEDDEPLSYAD------LINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPW---ARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYEIVSVYNSSAKQMVLEPGMKVHW--LKGSPPPDIPVCGFKNDNPACLAKTVTMHQMISIVACFIFIIIVTVTVFIYRKVKLENELAAQLWRVYWEDIQ----ISNL--------------DKALRRACSRLTLSLRGS--------------------------NYG-------------SLLTLEG-------NVQIYAKTCYYKGNITAIK-YVNKKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR-KESYL--EDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLDSPP-FSPKEIVEHV-AEGRWPYLRP-LLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHK-NNRGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTG 986

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 613.994 bits (1582), Expect = 0.000e+0
Identity = 305/518 (58.88%), Postives = 397/518 (76.64%), Query Frame = 3

Query: 2010 NAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSL-TAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            N Q+F KTA +KGN+VA+K  ++++RI++ R++L ++K ++D+ NDH+ RFIGAC++     +V +YCP+GSL+D+L  E ITLDW+FKYSLI DI +GM +LHN+ +   G LKSSNC+VD+RFVLKITD+GL S R        ED++ Y+   LW AP+LLRMSNPP  GT KGD+YSF I+ QE+  R+GVF ++  D  S +EIV+ V     P   RP++ T  H  +E+   L+++ W E+P  RP+F+ IK  +RK N+E  S +ILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIARM++A L A+  F I HRPD++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG P KIH+S ++  +L+ F  F +  RG +E+KGKG  +TYWL GE++
Sbjct:  561 NFQVFAKTAYFKGNIVAIK-YVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPY-LRPTVNTQAH--SEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1069

HSP 2 Score: 196.438 bits (498), Expect = 1.269e-50
Identity = 136/506 (26.88%), Postives = 235/506 (46.44%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWT-HGIYIYHKTAYTNVIPLYCH-ALGGYLTQEFEITV---------DYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG--NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETS 1730
            ++LPK  + +PW  P   PAI  A++ V S P + P   +    ++ E  D IC E+  A    V       P    GP C Y  +P+      W +P+++ GA   GF  +R   + ++T  G  H  L  G+      + + W+ H + ++  +         C+ A+ G  T+  E+ +         D  P+  Y E                +  I  +  V  +C  P    ++++   + N    E+VFI I +F     ++   PW   A   +++  AK+AY+S+  +T + P+N ++++F   +K  A + +N+  +  L+N     FYDG++LY  ALN++LA+     +   I + MWN T+ G+ G V ID  GDR  DF++ DM D  +  F+ VA + GT+     +P ++  W      IP   P CG+ N       + + +  + + V+  + +I F+   F+YR +KL+ EL A  W I WE ++ S
Sbjct:   53 VILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSES-IAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGF-SDRSDAYTSITNTGPTHKKL--GEFALHICRHFGWSQHALLMFGDSKMGE---RECYFAVEGLYTELKEVNITTVDLVFEEDSRPV-NYSEH---------------LQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPW---ARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 530

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Query: 2010 NAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSL-TAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            N Q+F KTA +KGN+VA+K  ++++RI++ R++L ++K ++D+ NDH+ RFIGAC++     +V +YCP+GSL+D+L  E ITLDW+FKYSLI DI +GM +LHN+ +   G LKSSNC+VD+RFVLKITD+GL S R        ED++ Y+   LW AP+LLRMSNPP  GT KGD+YSF I+ QE+  R+GVF ++  D  S +EIV+ V     P   RP++ T  H  +E+   L+++ W E+P  RP+F+ IK  +RK N+E  S +ILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIARM++A L A+  F I HRPD++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG P KIH+S ++  +L+ F  F +  RG +E+KGKG  +TYWL GE++
Sbjct:  561 NFQVFAKTAYFKGNIVAIK-YVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPY-LRPTVNTQAH--SEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1069

HSP 2 Score: 196.438 bits (498), Expect = 1.269e-50
Identity = 136/506 (26.88%), Postives = 235/506 (46.44%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWT-HGIYIYHKTAYTNVIPLYCH-ALGGYLTQEFEITV---------DYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG--NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETS 1730
            ++LPK  + +PW  P   PAI  A++ V S P + P   +    ++ E  D IC E+  A    V       P    GP C Y  +P+      W +P+++ GA   GF  +R   + ++T  G  H  L  G+      + + W+ H + ++  +         C+ A+ G  T+  E+ +         D  P+  Y E                +  I  +  V  +C  P    ++++   + N    E+VFI I +F     ++   PW   A   +++  AK+AY+S+  +T + P+N ++++F   +K  A + +N+  +  L+N     FYDG++LY  ALN++LA+     +   I + MWN T+ G+ G V ID  GDR  DF++ DM D  +  F+ VA + GT+     +P ++  W      IP   P CG+ N       + + +  + + V+  + +I F+   F+YR +KL+ EL A  W I WE ++ S
Sbjct:   53 VILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSES-IAPLMAVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGF-SDRSDAYTSITNTGPTHKKL--GEFALHICRHFGWSQHALLMFGDSKMGE---RECYFAVEGLYTELKEVNITTVDLVFEEDSRPV-NYSEH---------------LQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPW---ARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 530

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1a (natriuretic peptide receptor 1a [Source:ZFIN;Acc:ZDB-GENE-060503-539])

HSP 1 Score: 592.038 bits (1525), Expect = 0.000e+0
Identity = 301/516 (58.33%), Postives = 386/516 (74.81%), Query Frame = 3

Query: 2010 NAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            N Q++ KT  YKGN+ A+K + +++RI++ R++L ++K ++D+ N+H+ RFIGAC++     ++ +YCP+GSL+D++  E ITLDW+F+YSLI DI +GM +LHN+ +   G LKSSNCLVDSRFVLKITD+GL S R  + YL  ED++ Y+   LWTAPEL+R  N    GT KGDVYSF I+ QE+   KGVF LDS   FS +EIVE V AE      RP L      +E+   L+++ W+ED   RPDFN IK  + K N  G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTA+SAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH  EIARM++A L A++ F I HRPD +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S++T  +L+ F  F +  RG IE+KGKG  +TYWL GE+
Sbjct:  541 NVQIYAKTCYYKGNITAIKYV-NKKRIELTRKVLFELKHMRDVQNEHLNRFIGACIDAPNICILTEYCPRGSLQDLMEIESITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCLVDSRFVLKITDYGLASFR-KESYL--EDTHAYYARKLWTAPELMRDENRQPCGTQKGDVYSFGIILQELALLKGVFYLDSPP-FSPKEIVEHV-AEGRWPYLRP-LLCTQSHSEELGQLMQRCWSEDVNERPDFNQIKVMLHK-NNRGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTAMSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHTGEIARMSLALLEAVYSFRIRHRPDLQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDIEMKGKGRMRTYWLLGES 1048

HSP 2 Score: 165.622 bits (418), Expect = 4.476e-41
Identity = 111/398 (27.89%), Postives = 190/398 (47.74%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQ--YKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETK--YPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFK 1433
            ++LPK  + +PW  P   PA+  ALEKV S P + P   +     + E  + +C ++   L   V       P    GP C Y  +P+AR    W +P+++ GA   GF     + + ++T  G  H  L  G+ + +    + W     +       +  P Y    G Y     E+T D    +   + E        D      LI+ I  +  V  +C    +  +++++  +      EYVF  I LF     ++   PW   A   +++  AK+A++S+  +T + P+N ++++F  ++K  A +E+N+  E  L+N     F+DGVLLY+HALN+++   G    G ++ K MWN TF G+ G V +D +GDR  DF++ DM D ++G ++
Sbjct:   29 IILPKQNTEYPWAWPRVGPALNWALEKVNSDPTLLPGYHMQLVFSSSENKEGLCSDSVAPLV-AVDLKFAHDPWAFIGPGCDYASSPVARFTTHWEVPMVTAGAPALGF-----NMYSSITNTGPTHKKL--GEFVVRMHHNFGWHKYAMVMFHDKKNDDRPCYFAVEGPYT----EMTADNITAKDMVFNEDDEPLSYAD------LINGISQRGRVVYVCCKWDTFRKLMVQFYKQRLPQEEYVFFFIDLFGESLRSRPAKPW---ARGDADDEAAKQAFKSVKIMTYREPQNPEYKHFVSKMKRDAKKEFNFSIEDSLMNLIAGGFHDGVLLYSHALNESMDQSGLRPPGHVVTKKMWNRTFHGVTGLVQMDENGDREIDFALWDMTDTESGVYE 405

[Close]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Match: npr1b (atrial natriuretic peptide receptor 1-like [Source:NCBI gene;Acc:103022666])

HSP 1 Score: 567.77 bits (1462), Expect = 0.000e+0
Identity = 290/518 (55.98%), Postives = 377/518 (72.78%), Query Frame = 3

Query: 2010 NAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSL-TAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            N Q+F KTA +KGN+VA+K  ++++RI++ R++L ++K ++D+ NDH+ RFIGAC++     +V +YCP+GSL+D+L  E ITLDW+FKYSLI DI +GM +LHN+ +   G LKSSNC+VD+RFVLKITD+GL S R        ED++ Y+   LW AP+LLRMSNPP  GT KGD+YSF I+ QE+  R+GVF ++  D  S +EIV+ V     P   RP++ T  H  +E+   L+++ W E+P  RP+F+ IK  +RK N+E  S +ILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ                       VETIGDAYMV SGLP  NG LHAREIARM++A L A+  F I HRPD++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMESNG P KIH+S ++  +L+ F  F +  RG +E+KGKG  +TYWL GE++
Sbjct:  580 NFQVFAKTAYFKGNIVAIK-YVNRKRIELTRKVLFELKHMRDVQNDHLTRFIGACIDPPNVSIVTEYCPRGSLQDILENESITLDWMFKYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSFRTESD---PEDAHSYYARKLWMAPDLLRMSNPPACGTQKGDIYSFGIILQEVALRRGVFYIEG-DSLSPKEIVDRVALGEWPY-LRPTVNTQAH--SEELGQLMQRCWAEEPAERPEFSHIKVLLRKQNREV-SRDILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQ-----------------------VETIGDAYMVVSGLPVRNGKLHAREIARMSLALLDAVKTFKIRHRPDQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESNGEPLKIHVSSASHDILQEFNCFQLELRGDVEMKGKGKMRTYWLLGESK 1065

HSP 2 Score: 195.667 bits (496), Expect = 1.774e-50
Identity = 136/506 (26.88%), Postives = 235/506 (46.44%), Query Frame = 3

Query:  270 LMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWT-HGIYIYHKTAYTNVIPLYCH-ALGGYLTQEFEITV---------DYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG--NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETS 1730
            ++LPK  + +PW  P   PAI  A++ V S P + P   +    ++ E  D IC E+   L   V       P    GP C Y  +P+      W +P+++ GA   GF  +R   + ++T  G  H  L  G+      + + W+ H + ++  +         C+ A+ G  T+  E+ +         D  P+  Y E                +  I  +  V  +C  P    ++++   + N    E+VFI I +F     ++   PW   A   +++  AK+AY+S+  +T + P+N ++++F   +K  A + +N+  +  L+N     FYDG++LY  ALN++LA+     +   I + MWN T+ G+ G V ID  GDR  DF++ DM D  +  F+ VA + GT+     +P ++  W      IP   P CG+ N       + + +  + + V+  + +I F+   F+YR +KL+ EL A  W I WE ++ S
Sbjct:   72 VILPKTNTSYPWAWPRVGPAIDHAMKLVNSNPSLLPGYSLQFVFESSENTDGICSESIAPLM-AVDLKFAHEPWAFIGPGCDYTSSPVGLFTTHWGLPMITAGAPAVGF-SDRSDAYTSITNTGPTHKKL--GEFALHICRHFGWSQHALLMFGDSKMGE---RECYFAVEGLYTELKEVNITTVDLVFEEDSRPV-NYSEH---------------LQKIKEEGRVVFVCCSPDIFRQLMVHFRKANLPQEEFVFIYIDVFGRTLTSQPVQPW---ARGDADDELAKKAYQSVKILTYREPQNPEYKDFVMDLKAGAKKMFNFTVDDSLMNIISGGFYDGLMLYVQALNESLAESHGRPSSKSITERMWNRTYYGVTGLVQIDKHGDRETDFALWDMTDTNSSVFQIVAVYNGTQKQMRTLPGMAFHWP--GGFIPPDMPFCGFKNDNPACIARTITMHQMVSIVVFFILVIIFTITVFIYRKLKLEKELAAQLWRISWEDMQMS 549

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006352.1 (pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 gene:ENSPMAG00000005587.1 transcript:ENSPMAT00000006352.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 615.92 bits (1587), Expect = 0.000e+0
Identity = 312/536 (58.21%), Postives = 401/536 (74.81%), Query Frame = 3

Query: 1959 SCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLE-DVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGC-TEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            SC SL T  G N       Q+F KT  Y+GN+VA+KPI ++++I++ R++L ++K ++D+ N+H+ RF+GAC++     +V +YCP+GSL+ D+L  E ITLDWVF+YSLI DI +GM++LHN+ +G  G+LKSSNC+VDSRFVLKITD+GL S R   +    ED +  +   LWTAPELLR+ +PP  GT KGDVYS  I+ QEI  R G F ++  D  S +EIV+ VK    P  FRPS      C  E+  LL+++ W EDP  RPDF+ IK  + KFNKE +S NILDNLLSRMEQYANNLE++V+ERT+ YLEEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT+LSAESTPMQ++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG L+A+EIARM++A L A+  F I HR + +LKLRIGIH+GPVC+GVVGLKMPR+CLFGDTVNT+SRMESNG   KIH+SQ+T ++L  FG F +  RG +E+KGKG  +TYWL GE E
Sbjct:  303 SCGSLLTTQGRN-------QMFAKTGYYRGNLVAIKPI-NKKKIELTREVLFELKHMRDVLNEHLTRFVGACIDPPNICIVTEYCPRGSLQQDILENESITLDWVFRYSLINDIVKGMLFLHNSVIGSHGSLKSSNCVVDSRFVLKITDYGLASFRSCSEC---EDMHSLYAKKLWTAPELLRLEHPPPQGTQKGDVYSLGIILQEIALRNGTFYVEGMD-LSPKEIVQKVKNGQRPY-FRPSTD--ESCHIEELGLLMQRCWAEDPAERPDFSQIKMLIHKFNKE-NSTNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAETLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSLSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLNAKEIARMSLALLDAVKTFKIRHRQEDKLKLRIGIHTGPVCAGVVGLKMPRFCLFGDTVNTASRMESNGEALKIHVSQTTKEVLDEFGCFRLELRGDVEMKGKGKMRTYWLLGEIE 822

HSP 2 Score: 177.178 bits (448), Expect = 8.298e-46
Identity = 93/291 (31.96%), Postives = 156/291 (53.61%), Query Frame = 3

Query:  897 AVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSG------NETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETS--EKIR 1742
            +V   C   A   + +++A       G+YVF  +  FS        +E++ PW         + +AK AY++++ ++ + P+N ++++F  ++K+ A  ++N+  E  L+N    +FYD +++Y  ALNKTL+ GG + +G  I K+MWN T+ G+ G  TID +GDR  DFS+ D+ D  TGEF  V  + G  S  + VP + + W   S  IP   P CG++N  C       +   +   V   + LI   + + +YR +KL+ EL +M W + WE+++ S  EK R
Sbjct:    5 SVVYFCCSAAVFRQTMVQAHAEGMTAGDYVFFYVDPFSESLSESNVSESRKPW---KRGDEFDEQAKEAYKAVMIISYREPQNIEYKDFVVKLKKRAKEQFNFTIEDTLMNLIAGSFYDAIMMYTAALNKTLSSGGGVHDGHAITKHMWNRTYRGVTGEFTIDRNGDRETDFSLWDLTDMNTGEFNVVLSYDGASSKLIEVPGLEIQWPGGS--IPKDVPLCGFENEAC--ISGGFSTMEVLMIVFSLILLIVAVSSFLIYRKLKLEKELASMLWRLRWENIQVSSLEKAR 288

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: NPR1 (natriuretic peptide receptor 1 [Source:HGNC Symbol;Acc:HGNC:7943])

HSP 1 Score: 574.318 bits (1479), Expect = 0.000e+0
Identity = 280/511 (54.79%), Postives = 382/511 (74.76%), Query Frame = 3

Query: 2043 KGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGD------SGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            +GN+V + P +++++I++ RQ+L ++K ++D+ N+H+ RF+GAC+++    ++ +YCP+GSL+D+L  E I+LDW+F+YSL+ DI +GM+YLH++ +G  G LKSSNC+VDSRFVLKITD+GL S+R   +    + S  YF+  LWTAPELLR+      GT KGDVYSFAI+ QEI  R G F L++ +  +A+EIV+ VK    P   RP++    G +E+   L+++ W E+   RPDF+ IK  ++KF+ + D      +  ILDNLLSRMEQYANNLE++V+ERT+ YLEEK KAE LLY +LP SVA QL + + V AE++D VTI+ SDIVGFTA+SA+STPMQ++  LN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG  HA E+ARMA+A LSA+ CF I HRP + L LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRME+ G  H+IH+S +T  +L  +G F++   G +++KGKG+ +TYWL GEN
Sbjct:    1 QGNLVEI-PFINRKKIELTRQMLFELKHMRDVQNEHLTRFVGACIDVPNICIITEYCPRGSLQDILENESISLDWMFRYSLMHDIVKGMLYLHSSVIGSHGNLKSSNCVVDSRFVLKITDYGLSSVRAHSK---ADSSANYFEKRLWTAPELLRLEEVAPRGTQKGDVYSFAIILQEIALRSGPFYLEA-NHLTAKEIVQRVKLGEWPY-LRPTVDP-GGHSEELGHLMQRCWAEESTERPDFHQIKILLQKFSSQDDGPESPPAFTILDNLLSRMEQYANNLEELVEERTQAYLEEKGKAEALLYQILPHSVAEQLKRGETVPAEAFDSVTIYLSDIVGFTAMSAQSTPMQVVAFLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVHNGTRHAIEVARMALALLSAVRCFHIRHRPAQRLLLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMEAKGEAHRIHLSSTTKAILDEYGGFVVQLHGDVDIKGKGTMRTYWLLGEN 504

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008976.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008976.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 472.241 bits (1214), Expect = 6.035e-152
Identity = 307/799 (38.42%), Postives = 434/799 (54.32%), Query Frame = 3

Query: 1227 FYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTT---FEGIGGTVTIDSSGDRIADFSILDMDPK---TGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPK-PDKNLNIGAISAGVMGCLFLISFSA--GYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTR-NEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDI--NRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNM--YFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDD-------FSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
             +D  +LYA A+ + L  GG   +G  +I+ +  +    F G  G V+ID +G+R  D+++ D+  K   TGE +  +    T  +    P      G      PS  P CG+   +C + P    ++  +  G +  L +I   A   Y V ++  LQ            ES++T+    N  +   V     P+ N     ++S S+ + G + N   ++H    VE P                                                 +Y+GN VALK +      D+  NR  L    K++++ ++++  F G C+E+    +V  YC KGSL+DVL      LDW+FK S   DI  GM++LH +  PI   G LK S CL+DSR  +K+T FG+   R  K+    + +N+  +F  L WTAPELLRM + P++GT KGDV+SFAI+ +E++Y         ED+          ++I++ V+   +  P RP LT    C      LI+Q W+E    RPDF+++   +R  + EGD  NILDN++S++E+YAN+LE++V +RT Q   EKKK + LL S+LP  V  QL   + V  E Y+LVTIFF DIVGFTA+SA STP+++I+LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EIA M++ FLS+I  F I H P ++LKLRIGI+SGPV +GVVG  MPRYCLFGDTVN +SRMES G P  IH+S++T  LLK  G + + ERG I +KGKG+  TYWL G+
Sbjct:    4 LHDAGILYAMAVRELLRQGGNPRDGRAVIRTIRGSNKIKFYGASGQVSIDVNGERFLDYAVFDLQKKQTATGEMRIASKRYFTFQTINFTPEYQ-KMGWPDGRPPSDMPECGFTGELCQEAPISEPDLALVLVGSILSLIVIGTVAFLTYLVVQSRSLQ------------ESMDTTWWKINFEDITLV-----PLVNGS---YRSSSKQVSGNQSNVHHDVHGTDRVEIP-----------------------------------------------IGIYQGNQVALKFLERTHPPDLKSNRFAL----KMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKS--PIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINNLGSFFIELYWTAPELLRMEDLPVNGTPKGDVFSFAILMREVIYH--------EDEGPYVGIHLEPKDIIDQVRDGIAVPPLRPLLT--ERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGDM-NILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 717

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008986.1 (pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-1 gene:ENSPMAG00000008096.1 transcript:ENSPMAT00000008986.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 432.565 bits (1111), Expect = 5.634e-138
Identity = 239/492 (48.58%), Postives = 323/492 (65.65%), Query Frame = 3

Query: 2103 QLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLR-GSKQYLL----EEDS-NMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            ++ I + +++++ ++++  F G C+E+    +V  YC KGSL+DVL      LDW+FK S   DI  GM++LH +  PI   G LK S CL+DSR  +K+T FG+   R G K   L    +ED+  +  K L WTAPELLRM + P++GT KGDV+SFAI+ +E   R+   +  + +     +I++ V+   +  P RP LT    C      LI+Q W+E    RPDF+++   +R  + EG   NILDN++S++E+YAN+LE++V +RT Q   EKKK + LL S+LP  V  QL   + V  E Y+LVTIFF DIVGFTA+SA STP+++I+LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EIA M++ FLS+I  F I H P ++LKLRIGI+SGPV +GVVG  MPRYCLFGDTVN +SRMES G P  IH+S++T  LLK  G + + ERG I +KGKG+  TYWL G+
Sbjct:  142 EIPIGIYQMREMLHENLVIFFGVCVELPNVCIVTQYCRKGSLKDVLKTSDFELDWMFKTSFAHDIVNGMIFLHKS--PIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRYGKKGKTLDINKQEDAWALSSKELYWTAPELLRMEDLPVNGTPKGDVFSFAILMRESTPREWPTATRA-NRVPFPDIIDQVRDGIAVPPLRPLLT--ERCEPRIQALIRQCWDESADRRPDFSSVSRMLRLASPEGLHMNILDNMVSKLEKYANHLEEVVDDRTAQLESEKKKTDRLLSSLLPGIVVDQLKAGKTVQPEQYELVTIFFCDIVGFTAMSAISTPLEVINLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEIATMSLHFLSSIMNFRIRHLPQEQLKLRIGINSGPVVAGVVGNTMPRYCLFGDTVNVASRMESTGFPLHIHVSEATTNLLKQIGGYFLVERGTINLKGKGNQLTYWLKGK 628

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BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008942.1 (pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 gene:ENSPMAG00000008084.1 transcript:ENSPMAT00000008942.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 445.277 bits (1144), Expect = 1.039e-137
Identity = 243/522 (46.55%), Postives = 341/522 (65.33%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDI-NRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRK------GVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            ++FT   +Y+GN VALK +   R  D+ ++ LL +++ +++L ++++  F G C+E+    +V  YC KGSL+DVL      LD +FK S   DI  GM++LH +  PI   G LK S CL+DSR  +K+T FG+   R  K+  + + +N     L WT+PELLRM   P++GT KGDV+SF ++ +E++Y +      GV       D   +EI++ V+      P RP LT    C      LI++ W+E P  RPDF++I   +R  + EG   +ILDN++S++E+YAN+LE++V++RT Q   EKKK + LL S+LP  V  QL   + V  E ++ VTIFF DIVGFTA+SA S+P+++I LLN LY   D II+ YDVYKVETIGDAYMV SGLP  NG  H  EI+ M++ FLS+I  F I H P ++LK+RIG++SG V +GVVG  MPRYCLFGDTVN +SRMES G P +IH+S+ST  LLK+ G + + ERG I++KGKGS  TYWL+G+
Sbjct:  543 KMFTPLGIYQGNQVALKFLQRTRPPDLKSKTLLKELQMLRELRHENLVVFFGVCVEMPNICIVTQYCRKGSLKDVLKTSDFELDLMFKTSFAYDIVNGMIFLHKS--PIKSHGNLKPSTCLLDSRLQIKLTGFGIWEFRHGKKGKIMDVNNQDIAELFWTSPELLRMEIFPVNGTPKGDVFSFGVLMREMIYHEDEGPYVGV-------DMEPKEIIDQVREGKCSPPLRPLLT--ERCEPRIQALIQRCWDESPDRRPDFHSIARMLRSASPEGHR-SILDNMVSKLEKYANHLEEVVEDRTAQLESEKKKTDRLLSSLLPSVVVEQLKAGKTVQPEHFEQVTIFFCDIVGFTAMSAISSPLEVITLLNDLYNLLDDIIKEYDVYKVETIGDAYMVASGLPVRNGVRHVEEISIMSLHFLSSIINFRIRHLPKEQLKIRIGVNSGSVVAGVVGNTMPRYCLFGDTVNVASRMESTGYPLRIHVSESTASLLKSIGGYELVERGAIQLKGKGSQLTYWLNGK 1052

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC5 (Polo-like kinase; controls targeting and activation of Rho1p at cell division site via Rho1p guanine nucleotide exchange factors; regulates Spc72p; also functions in adaptation to DNA damage during meiosis; regulates the shape of the nucleus and expansion of the nuclear envelope during mitosis; similar to Xenopus Plx1 and S. pombe Plo1p; human homologs PLK1, PLK3 can each complement yeast cdc5 thermosensitive mutants [Source:SGD;Acc:S000004603])

HSP 1 Score: 60.8474 bits (146), Expect = 9.375e-10
Identity = 69/314 (21.97%), Postives = 137/314 (43.63%), Query Frame = 3

Query: 2037 LYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISL---RGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQ 2969
            ++    VA   I S++     ++LL +++  K +++ +I +FI    +    Y++ + CP GSL ++L + ++  +   ++   Q IC  + Y+H+       LK  N   DS + LKI DFGL ++      ++Y +    N       + APE+L   +     +F+ D++S  ++   ++  K  F            I E +K  +   P    +      +++  +LI+   + DP+ RP    I  ++         G    ++ S +   A N EDI +E++    ++  +   LL SM    +  Q
Sbjct:  106 IFAAKTVAKASIKSEK---TRKKLLSEIQIHKSMSHPNIVQFIDCFEDDSNVYILLEICPNGSLMELLKRRKVLTEPEVRFFTTQ-ICGAIKYMHSRRVIHRDLKLGNIFFDSNYNLKIGDFGLAAVLANESERKYTICGTPN-------YIAPEVLMGKHS--GHSFEVDIWSLGVMLYALLIGKPPFQAR-----DVNTIYERIKCRDFSFPRDKPI------SDEGKILIRDILSLDPIERPSLTEIMDYV------WFRGTFPPSIPSTVMSEAPNFEDIPEEQSLVNFKDCMEKSLLLESMSSDKIQRQ 389

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN1 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN1 has a paralog, KIN2, that arose from the whole genome duplication [Source:SGD;Acc:S000002529])

HSP 1 Score: 60.077 bits (144), Expect = 2.161e-9
Identity = 50/182 (27.47%), Postives = 83/182 (45.60%), Query Frame = 3

Query: 2136 LNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQD---------ICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAE 2654
            L + HICR    C    + YM+++Y   G L          LD++ ++  I++         I   ++YLH N      LK  N ++     +KI DFGL ++  S++ L     + +  +L + APELL+ +  P  G  + DV+SF +V   +V   G    D E+     E ++  K E
Sbjct:  201 LYHPHICRLFEMCTLSNHFYMLFEYVSGGQL----------LDYIIQHGSIREHQARKFARGIASALIYLHANNIVHRDLKIENIMISDSSEIKIIDFGLSNIYDSRKQL-----HTFCGSLYFAAPELLKAN--PYTGP-EVDVWSFGVVLFVLVC--GKVPFDDENSSVLHEKIKQGKVE 362

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: STE11 (Signal transducing MEK kinase; involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p; protein abundance increases in response to DNA replication stress [Source:SGD;Acc:S000004354])

HSP 1 Score: 56.9954 bits (136), Expect = 1.523e-8
Identity = 49/183 (26.78%), Postives = 84/183 (45.90%), Query Frame = 3

Query: 2127 VKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICR----GMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSP 2663
            +K+L++++I  + GA  E G   +  +Y P GS+  +L          F+ SLI +  R    G+ YLH        +K +N L+D +  +KITDFG IS + S     +        ++ W +PE+++ +      T K D++S   V  E+   K  F      DFS  + +  +    +P
Sbjct:  508 LKELHHENIVTYYGASQEGGNLNIFLEYVPGGSVSSMLNNY-----GPFEESLITNFTRQILIGVAYLHKKNIIHRDIKGANILIDIKGCVKITDFG-ISKKLSPLNKKQNKRASLQGSVFWMSPEVVKQTAT----TAKADIWSTGCVVIEMFTGKHPFP-----DFSQMQAIFKIGTNTTP 675

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: KIN2 (Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; KIN2 has a paralog, KIN1, that arose from the whole genome duplication [Source:SGD;Acc:S000004086])

HSP 1 Score: 55.8398 bits (133), Expect = 4.097e-8
Identity = 49/171 (28.65%), Postives = 79/171 (46.20%), Query Frame = 3

Query: 2136 LNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVK 2648
            L + HICR    C    + YM+++Y   G L D + +   +L         + I   + YLH N      LK  N ++ S   +KI DFGL ++   ++ L     + +  +L + APELL+    P  G  + D++SF IV   +V  K  F     DD ++  + E +K
Sbjct:  180 LYHPHICRLFEMCTMSNHFYMLFEYVSGGQLLDYIIQHG-SLKEHHARKFARGIASALQYLHANNIVHRDLKIENIMISSSGEIKIIDFGLSNIFDYRKQL-----HTFCGSLYFAAPELLKAQ--PYTGP-EVDIWSFGIVLYVLVCGKVPF-----DDENSSILHEKIK 336

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BLAST of Guanylate cyclase vs. Ensembl Yeast
Match: CDC15 (Protein kinase of the Mitotic Exit Network; localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II; relocalizes to the cytoplasm upon DNA replication stress [Source:SGD;Acc:S000000072])

HSP 1 Score: 54.6842 bits (130), Expect = 9.720e-8
Identity = 36/153 (23.53%), Postives = 76/153 (49.67%), Query Frame = 3

Query: 2040 YKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELL 2498
            +   VVA+K ++ +   ++N  ++ ++  +K+LN+++I ++ G   +    Y++ +YC  GSL  ++++    L      + +     G+ YLH        +K++N L+ +   +K+ DFG+ ++  S    L    N       W APE+L
Sbjct:   46 HTDQVVAIKEVVYENDEELN-DIMAEISLLKNLNHNNIVKYHGFIRKSYELYILLEYCANGSLRRLISRSSTGLSENESKTYVTQTLLGLKYLHGEGVIHRDIKAANILLSADNTVKLADFGVSTIVNSSALTLAGTLN-------WMAPEIL 190

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO30985 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SZ80])

HSP 1 Score: 506.908 bits (1304), Expect = 4.283e-167
Identity = 257/494 (52.02%), Postives = 352/494 (71.26%), Query Frame = 3

Query: 2073 LSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHN-NLGPIGTLKSSNCLVDSRFVLKITDFGLISLRG-SKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKF-NKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAI-FCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWL 3542
            L +R IDI+RQLL+++K+++D+ +D++ +FIGAC+      +V  YC +GSL+D+L  + + LD VF  SL+ DI +GM YLHN ++   G LKSSNCLVDSR+VLKITD+GL  LR  SK+  +E +    +++LLW APE+LR+ + P  GT KGDVYSF+I+ QE   R G +S +       + I+E V+    P P+RP +  +    E+   L+KQ W EDP LRPDF  IK  +R+  +K G   NI DN+++ ME YA+NLE++V +RT+Q ++EK+K + LL S+LP+ VA QL K + V AES++ VTI+FSDIVGFT+LSAESTPMQ++  LN LYT FD II+ YDVYKVETIGDAYMV SGLP  NG  HA EIA+MA+  + A+   F++ H+P+ +L+LR+G H+GPV +GVVG  M RYCLFGDTVNT+SRMESNG P +IHISQ T  +L   GTF++  RG + +KGKG+ +T+WL
Sbjct:    8 LPKRTIDISRQLLLEMKQMRDIRHDNLNQFIGACVGPPNVCIVMQYCSRGSLQDILENDDVKLDLVFIASLLSDIVKGMEYLHNSDIRSHGNLKSSNCLVDSRWVLKITDYGLPLLRSRSKKSTIETN----WRDLLWVAPEILRIPSRPPKGTHKGDVYSFSIILQEFHTRDGPYSANY---MEPKAIIEKVRKSEFP-PYRPIVANLIDGAEELRDLMKQCWAEDPDLRPDFTEIKKTVRRIVDKSGMKKNIFDNMVNMMEIYADNLENLVAQRTDQLVDEKRKTDALLESILPRPVAEQLKKGKAVEAESFNEVTIYFSDIVGFTSLSAESTPMQVVTFLNDLYTIFDDIIQEYDVYKVETIGDAYMVASGLPIRNGRRHAGEIAKMALHLVDAVSHNFIVRHKPEYKLQLRVGCHTGPVVAGVVGNTMARYCLFGDTVNTASRMESNGEPLRIHISQQTKDVLDELGTFVVKSRGKVHLKGKGTVETFWL 493

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BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO34275 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SPS9])

HSP 1 Score: 504.982 bits (1299), Expect = 6.564e-167
Identity = 272/523 (52.01%), Postives = 358/523 (68.45%), Query Frame = 3

Query: 2004 IQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN--MYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAI--HGCT-EDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            I   Q+FT   +YK N+VA+K I ++R+I++ R++  ++K ++ + ++++  F GAC+E     ++  YCPKGSL+D+L  E I LD +F  SL+ DI +GM YLH+  +   G LKS NC+VD R+VLKITD+GL   + S Q + EE+    MY++ L WTAPELLR ++P   GT KGDVYSF I+ QE++ R G F L    +    +I+E V    SP PFRP L+ I   G T    V L K  W E+P  RPDF  I+  +RK    G   NI+DN+++ +E+YANNLE +V+ERT Q  +EK+K E+LL  MLP SVA  L+  + V AE++D V+IFFSDIVGFT+LS+ESTP+Q++DLLN LYT FD II NYDVYKVETIGDAYMV SGLP  NG+ HA EIA MA+  L  I  F I HRP+ +LKLRIGIHSG   +GVVG KMPRYCLFGDTVNT+SRMESNG   KIHIS ST ++L   G + + +RG + +KGKG+  TYWL G +
Sbjct:    2 INQRQIFTTVGIYKSNMVAIKRI-NKRQIELTREIKYEMKLMRTVRHENLVTFTGACVEPPNICILLQYCPKGSLQDILENEDIKLDSMFVNSLLTDIVKGMAYLHSTEIRSHGRLKSPNCVVDGRWVLKITDYGLNKFK-SNQDISEEEGEYAMYYRKL-WTAPELLRAADPRPRGTQKGDVYSFGIIVQELLTRSGPFDLSYYTN-EPSDIIEKVTRVESP-PFRPKLSTIVLEGPTVAGIVDLAKWCWEENPDHRPDFEEIRKTVRKL-PMGKQSNIMDNMVNLLEKYANNLESLVEERTSQLADEKRKTENLLNRMLPPSVAKDLVHGKQVTAENFDEVSIFFSDIVGFTSLSSESTPLQVVDLLNDLYTLFDEIINNYDVYKVETIGDAYMVVSGLPIRNGHQHAGEIATMALHMLREIDSFKIRHRPNDKLKLRIGIHSGSCVAGVVGKKMPRYCLFGDTVNTASRMESNGEALKIHISPSTKRILDELGGYHIQKRGKVFLKGKGTWITYWLVGSD 518

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36203 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA1])

HSP 1 Score: 407.527 bits (1046), Expect = 9.242e-130
Identity = 227/516 (43.99%), Postives = 324/516 (62.79%), Query Frame = 3

Query: 1899 LSRNNSKNFGN--PIYKDLDLISCASLETIAGINLDKIQNAQLF---TKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLH-NNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELL---RMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGL 3419
            LSR+   N+ +  P+  D    S     +++G   D   +  LF    + +  K  +VALK +L +  + + R +LI++K+V+D+ + ++  +IG C       +V  YC +GSL+++LA ++I+LDW F+ S   DI  GM  +H +++   G L+SS CL+DSR+V K+ DFGL  L+ +++   E   +  +  L W APELL   + +N P+  T  GDVYSF I+  E++ R+  ++     +F+  E++E ++   +P PFRP  T           L+ Q WN+DP  RP F+ IK  +R    +G   +I+DN+L  ME Y   LE IV ERT Q  +EK K ++LLY MLP+ +A  L + +PV AESY  VTIFFSDIVGFT L+A STP+Q++DLLN LYT FD+II+ +DVYKVETIGDAYMV SGLP  NG+ HA EIA MA+  LS++  F   H P++ + LRIGIH+G   +GVVGLKMPRYCLFGDTVN +SRMES G+
Sbjct:   13 LSRSWIINYDDIQPVNMDTRFASKVRYSSVSGNMCDYSISLALFPWFCEHSFIKSYLVALK-MLRKDSLTLTRDMLIEMKQVRDVQHTNLLHYIGVCTTPPNICIVSQYCHRGSLQEILANDEISLDWFFRESFANDIAMGMHVIHTSSIHVHGDLRSSKCLIDSRWVCKVADFGLNLLKANQRPDPEIGVHAQYSRLFWRAPELLQNEKSTNKPVP-TQMGDVYSFGIILNELLTREEPYA---TTEFAPIEVIERIRCHLNP-PFRPE-TPFEIRNRSVTKLMTQCWNDDPQARPTFSDIKRQLRLL--KGGKSSIVDNMLRLMENYTEQLETIVDERTRQLADEKAKTDELLYKMLPRYIAESLKRGEPVIAESYSSVTIFFSDIVGFTELAAASTPLQVVDLLNDLYTCFDTIIDKHDVYKVETIGDAYMVVSGLPVRNGHRHAGEIATMALNLLSSMGNFRARHLPNRPIHLRIGIHTGSCVAGVVGLKMPRYCLFGDTVNYASRMESTGV 519

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO27923 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7T7X3])

HSP 1 Score: 400.979 bits (1029), Expect = 1.713e-128
Identity = 209/434 (48.16%), Postives = 288/434 (66.36%), Query Frame = 3

Query: 2235 VLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPI---GTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLD---GTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAI--HGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVK 3512
            +L  + I LDW+F+ S   DI  GM  +HN+  PI   G LKSSNCL+DSR+  KITD+GL  LR + Q   +      ++NL WT PELL +++   D    T  GDVYS+ IV  EI+ R   +S ++ D  S+++++E V+    P  FRP  +           V + +  W+ D   RP F+ IK  + K N  G + NI+DN+++ M +Y + LEDIV+ERT+Q  EEK K ++LLY MLP+ +A +L K  PV+AES+  VTIFFSDIVGFT+++A+STP+Q++DLLN+LYT FD +++ +DVYKVETIGDAYMV SGLP  NG  HA E+A MA+  LS +  F IPH P ++++LRIGIHSG   +GVVGLKMPRYCLFGDTVN +SRMES+GL  +IH+S    ++L   G + + ERG + +K
Sbjct:    2 LLGNDSIKLDWMFRQSFANDIATGMEAIHNS--PIQAHGNLKSSNCLIDSRWACKITDYGLDLLRAN-QTPKDIGEFAVYRNLFWTVPELLPLADGFKDHKNKTQAGDVYSYGIVLYEIITRDEPYSTNT-DTLSSKDVIELVRKRQEP-AFRPQFSKFMEEKSGHKMVQVTQDCWDNDAQKRPTFSAIKKKL-KANGMGKNLNIVDNMITMMAKYTDQLEDIVEERTKQLAEEKAKTDELLYKMLPRPIADELKKGNPVSAESFQSVTIFFSDIVGFTSVAAQSTPLQVVDLLNQLYTRFDKVVDEHDVYKVETIGDAYMVVSGLPVRNGERHAGEVASMALNLLSEVRDFQIPHIPSRKVQLRIGIHSGSCVAGVVGLKMPRYCLFGDTVNYASRMESSGLALRIHVSPECKEVLDRLGGYHLDERGPVTMK 429

[Close]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Match: EDO36204 (Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7SJA3])

HSP 1 Score: 392.889 bits (1008), Expect = 1.126e-124
Identity = 231/489 (47.24%), Postives = 291/489 (59.51%), Query Frame = 3

Query: 2127 VKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLH-NNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQ-YLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELK-----------LRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            V  L++ +I  +IG C+      +V + C +GSL DVL  + I LDW FK S   DI  GM  LH + +   G L SSNCLVD  +V KI D+GL   R SK  Y  EE         LW APE +R  N    G+  GDVYSF ++  EIV R   F    E   +   I+  + +   P P RP+L A   C       IKQ W+E+P  RP F  IK  MRK N  G S  ++D++L +M+ Y+NNLE +V+ERT Q   EK K + LLY MLP+ VA QL   + V AE +D VT+FFSDIVGFT LS+ STP+Q++  LN LYT FD+II NYDVYKVETIGDAYMV SGLP+ N + HA EIA MA+  L  I  F I H PD  L            L   I SGP  +GVVG+K PRY +FGDTVN +SRMESNG+P++IHIS    + L   G + M  RG IE+KGKG   TY+L+G++
Sbjct:    2 VHKLSHVNINPYIGVCITAPNICIVSEACGRGSLADVLINDDIKLDWTFKMSFATDIAAGMEALHASEVSFHGNLTSSNCLVDRMWVCKIADYGL--QRFSKHTYEPEEQLTGQTGKSLWMAPEHMR--NASSTGSQPGDVYSFGVILSEIVTRCEPF----ETLRATTSILRRIMSTEFP-PLRPTLNA-DDCDPTITKFIKQCWSEEPSARPTFRDIKKSMRKING-GRSLRLVDSMLGKMDIYSNNLEVLVEERTRQLEAEKAKTDQLLYEMLPRPVADQLKSGKSVEAELFDQVTVFFSDIVGFTKLSSSSTPIQVVTFLNDLYTYFDNIIPNYDVYKVETIGDAYMVVSGLPEKNRDRHAGEIATMALHLLCDIRTFKIRHVPDTRLVSSYSLLLIITCLFYLIFSGPAVAGVVGIKKPRYDVFGDTVNVASRMESNGVPNRIHISAECRKALLNLGGYHMERRGEIELKGKGKVITYFLNGKD 479

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 744.962 bits (1922), Expect = 0.000e+0
Identity = 446/1120 (39.82%), Postives = 645/1120 (57.59%), Query Frame = 3

Query:  273 MLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNPIVK---SLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIY---------HKTAYTNVIPLYCHALGGYLTQEFEITV-DYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFS---SGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGG------AISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            +LP   + +PW  P   PA+  A++ V S P++ P +K      + E  +  C ++   L   V   ++  P    GP C Y  +P+AR    W++P+++ GA   GF     S+F  +T  G  H  L  G+   K  + + W H   +           +T Y  +  LY       L  +  ITV DY+                    + L+  I     V  LC    ++  ++++  +   +   YVF  I LF+    G +   PW+       ++  A+ A+RS+  +T   P+N ++  F + +K+ A + +N+  +  L N     FYDGV+LY+ ALN+TL+             G ++ + MWN TF+G+ GTV +D  GDR  DF++ DM D  +G+F+ V  +  +    ++   ++  W   S   P   P CG+ N         + +  + A V+  +F+I  +   F+YR +KL+ EL A  W + W  ++ S  +  ++   C          S++ +      ++KG+                          N+G             SL T+ G       N Q++TKT  YKGN+VA+K I +++RI++ R +L ++K ++D++N+H+ RFIGAC++     ++ +YCP+GSL+D++  E +TLDW+F+YSLI DI +GM +LHN+ +   G LKSSNC+VDSRFVLKITD+GL SLR S      +D++ Y+   LWTAPELLR  +PPL GT KGDVYSF I+ QE+   KGVF +D+      +EI++ V     P   RPSL   H  +E+  +L+++ W E+P  RPDFNTIK  +RK ++ G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH RE+ARMA+A L A+  F I HRP ++L+LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES G   KIH+S++T Q+L+ F TF +  RG IEVKGKG  +TYWL GE+
Sbjct:   35 ILPLTNTDYPWAWPRVAPALYRAVDSVNSDPHLLPGLKLQLVHGSSENREGFCSDSAAPLV-AVDLKLSHDPWAFIGPGCDYSSSPVARFTTHWDVPMVTAGARADGF-----SKFAAVTNTGPTHKKL--GEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCYFAIEGLYS------LMGKHNITVFDYF-------------VESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFRSVKVLTYMEPQNAEYHQFVETLKKDAEKMFNFTIKDSLYNLIAGGFYDGVMLYSRALNETLSKRKPGLRPVQRPKGDMVTQRMWNRTFQGVMGTVEMDKFGDREIDFALWDMTDINSGKFEVVCVYNSSIKELVLQKGLNFQWPGGSP--PLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMS-NLDKVLRRAC----------SRLTI------SMKGS--------------------------NYG-------------SLMTMEG-------NLQIYTKTGYYKGNLVAIKYI-NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHT-LIPKEIIQGVIRGGVP-LLRPSL-CFHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGED 1051

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc7 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125819])

HSP 1 Score: 663.685 bits (1711), Expect = 0.000e+0
Identity = 427/1114 (38.33%), Postives = 610/1114 (54.76%), Query Frame = 3

Query:  273 MLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNPIVK---SLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIY---------HKTAYTNVIPLYCHALGGYLTQEFEITV-DYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFS---SGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGEN 3554
            +LP   + +PW  P   PA+  A++ V S P++ P +K      + E  +  C ++   L   V   ++  P    GP C Y  +P+AR    W++P+++ GA   GF     S+F  +T  G  H  L  G+   K  + + W H   +           +T Y  +  LY       L  +  ITV DY+                    + L+  I     V  LC    ++  ++++  +   +   YVF  I LF+    G +   PW+       ++  A+ A+R        +     F +FS          YN      L  T     +  + + +  +                    W     G+ GTV +D  GDR  DF++ DM D  +G+F+ V H         +   ++  W   S   P   P CG+ N         + +  + A V+  +F+I  +   F+YR +KL+ EL A  W + W  ++ S  +  ++   C          S++ +      ++KG+                          N+G             SL T+ G       N Q++TKT  YKGN+VA+K I +++RI++ R +L ++K ++D++N+H+ RFIGAC++     ++ +YCP+GSL+D++  E +TLDW+F+YSLI DI +GM +LHN+ +   G LKSSNC+VDSRFVLKITD+GL SLR S      +D++ Y+   LWTAPELLR  +PPL GT KGDVYSF I+ QE+   KGVF +D+      +EI++ V     P   RPSL   H  +E+  +L+++ W E+P  RPDFNTIK  +RK ++ G   NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D VTI+FSDIVGFTALSAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LH RE+ARMA+A L A+  F I HRP ++L+LRIG+HSGPVC+GVVGLKMPRYCLFGDTVNT+SRMES G   KIH+S++T Q+L+ F TF +  RG IEVKGKG  +TYWL GE+
Sbjct:   35 ILPLTNTDYPWAWPRVAPALYRAVDSVNSDPHLLPGLKLQLVHGSSENREGFCSDSAAPLV-AVDLKLSHDPWAFIGPGCDYSSSPVARFTTHWDVPMVTAGARADGF-----SKFAAVTNTGPTHKKL--GEFSLKIQETFGWHHHTMLIFSDNKDDNDERTCYFAIEGLYS------LMGKHNITVFDYF-------------VESNINHKELVQIIQKNGRVVYLCCSWDNMRSLMVQFWKEGVDLENYVFFFIDLFAEGLGGEKPGMPWF---RGDQDDHAARLAFR--------VRHPSIFNSFS---------VYN------LSTTITPQSFMQIKMCSEPV--------------------WCVVSAGVMGTVEMDKFGDREIDFALWDMTDINSGKFE-VKH---------LPKGLNFQWPGGSP--PLEVPECGFKNDNPACLTSTVTMHQMVAMVICFVFVIIITITIFIYRKLKLENELAAQLWRVSWVDIQMS-NLDKVLRRAC----------SRLTI------SMKGS--------------------------NYG-------------SLMTMEG-------NLQIYTKTGYYKGNLVAIKYI-NKKRIELTRNVLFELKHMRDVHNEHLTRFIGACVDPPNMCIITEYCPRGSLQDLMESESMTLDWMFRYSLINDIVKGMTFLHNSVIFSHGNLKSSNCVVDSRFVLKITDYGLQSLRTSS---CPDDTHAYYARKLWTAPELLRTEDPPLCGTQKGDVYSFGIILQELALLKGVFYIDTHT-LIPKEIIQGVIRGGVP-LLRPSL-CFHSHSEELGVLMQRCWCEEPGERPDFNTIKILLRKQHR-GYGSNILDNLLSRMEQYANNLEELVEERTQAYNEEKRKAEALLYQILPHSVADQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREVARMALALLDAVKSFKIRHRPSQQLRLRIGVHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALKIHVSEATRQVLQEFNTFQLQPRGEIEVKGKGHMRTYWLQGED 992

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: olgc2 (membrane guanylyl cyclase [Source:NCBI gene;Acc:100125799])

HSP 1 Score: 599.742 bits (1545), Expect = 0.000e+0
Identity = 297/517 (57.45%), Postives = 391/517 (75.63%), Query Frame = 3

Query: 2010 NAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENE 3557
            N Q+F KT  YKGN+VA+K   +++RI++NR++L ++K ++D+ N+H+ RFIGAC++     ++ +YCP+GSL+D+L  + ITL+W+FK+SLI DI +GMV+LHN+ +   G LKSSNC+VD+RFVLKITD+GL + R  ++  +  DS+ Y+   LW APELLRM NPP  GT KGDVYSF+I+ QE+  R+G F LD  D  S +EIV+ V   + P   RPS+      + +   L+++ W E+P  RPDFN I+  +RK NKE  + NILDNLLSRMEQYANNLE++V+ERT+ Y EEK+KAE LLY +LP SVA QL + + V AE++D V+I+FSDIVGFTALSAESTPM+++ LLN LYT FD++I+N+DVYKVETIGDAYMV SGLP  NG LH REIARMA+A L  +  F I HRP+++LKLRIGIHSGPVC+GVVGLKMPRYCLFGDTVNTSSRMES+G   KIH+S +T  +L  F +F +  RG I++KGKG   TYWL GE++
Sbjct:  552 NLQVFAKTGYYKGNIVAIK-YTNKKRIELNRKVLFELKHMRDVQNEHLTRFIGACVDPPNICIITEYCPRGSLQDILENDSITLEWMFKFSLINDIVKGMVFLHNSVIFSHGKLKSSNCVVDNRFVLKITDYGLSTFR--QESDVGSDSHSYYAQKLWMAPELLRMENPPPQGTQKGDVYSFSIILQEVALRRGAFYLDG-DPLSPKEIVDRVILGDWPC-LRPSIDP-QSHSPELGQLMQRCWAEEPTERPDFNHIRLLLRKHNKESRT-NILDNLLSRMEQYANNLEELVEERTQAYHEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVSIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGKLHGREIARMALALLDTVRTFRIRHRPEQQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRMESSGEALKIHVSAATRDVLIEFNSFQLELRGDIDIKGKGKMTTYWLLGESD 1061

HSP 2 Score: 196.823 bits (499), Expect = 7.359e-51
Identity = 137/504 (27.18%), Postives = 233/504 (46.23%), Query Frame = 3

Query:  237 KRPDRIYPLAMLMLPKNFSMFPW--PLTIPAIKIALEKVKSMPYMNP---IVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETS 1730
            +RP +   LA++ LP+  + +PW  P   PA++ A+ K+ S P + P   +    K+ E  + IC E+   L   V       P    GP C Y  +P+      W++P+++ GA    F       + T+T  G  H  L  G+   +  + + W   + +       +  P Y  A+ G   +   I +        ++             Q L D I N   V  +C  P    R++++  + +  + +YVF+ I LF+     K PW   A    +++ AK A++S+  ++ + P+N++++ F   +K  A   +NY  +  L+N     FYDG++LYAHALN+T    GA   G LI   MWN TF G+ G + +D SGDR  DF++ D+ D  +  F+ V  +   +     VP  SV W  +    P   P+CG+ N       K + I  + +  +  +F ++ +   F+ R +KL+ EL A  W I W+ ++ S
Sbjct:   39 ERPRQNITLAII-LPETNTAYPWAWPRIGPALERAIIKINSDPNLLPNHHLTYVFKSSENSNGICSESVAPLV-AVDLEFAYKPWAFIGPGCSYTASPVGLFTTHWDVPLITAGAPAIAFLD---GIYPTITNTGPTHKKL--GRFALRICEHFGWREYVTLMFSDNKEDDRPCY-FAMEGLYEELKSINI------SLQDSVFEENKPPINYSQILAD-IQNIGRVMFVCCSPDVFRRLMIEFWKADLPHEQYVFLYIDLFAVSLSNKQPW---ARGDQDDTIAKDAFQSVKILSYREPQNQEYQQFVRDLKADAKTSFNYSVQDSLMNIIAGGFYDGLMLYAHALNETALVPGARPPGKLISGKMWNRTFHGVTGLLHLDVSGDRETDFALWDLVDTNSSSFQIVVVYNSFEEQVTPVPGTSVRW--LGGARPLDVPKCGFKNDNPACLTKTITIHQMVSITLFFIFTMTLTIAIFICRKMKLEKELVAQLWRISWDDIQMS 522

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 589.726 bits (1519), Expect = 0.000e+0
Identity = 297/513 (57.89%), Postives = 386/513 (75.24%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            QLF KT  +KGN+VA+K + +++RI++ RQ+L+++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  E I LDW+F+YSLI DI +GM +LHN+  G  G LKSSNC+VDSRFVLKITD+GL S R S +    +DS+  +   LWTAPELL   + P  GT KGDVYSF I+ QEI  R G F ++S D  S +EIV+ V+    P  FRP+ T     +E+  +L++  W EDP  RPDF  IK +M K NKEG S +IL+NLLSRMEQYANNLE++V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIA M++A L  +  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T ++L  F  F +  RG +E+KGKG  +TYWL GE
Sbjct:  492 QLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPY-FRPT-TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 996

HSP 2 Score: 118.242 bits (295), Expect = 2.415e-26
Identity = 71/227 (31.28%), Postives = 120/227 (52.86%), Query Frame = 3

Query: 1062 ENSRAKRAYR---SLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            EN R+K  ++   S+  +T   P+N ++++F  ++   A R++  + E  L++    +FYDG +LYA AL++TLA+GGA +NG  I +   N +F G+ G V+ID    R  D  +  M + +TGE+  V+++ G+    +      + W S     P   P C +  D+  C      L I A+ +G+   +F IS    + +YR +KL+ EL  M W + WE L+
Sbjct:  236 ENGRSKFTHQYDTSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP--PLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGIS---SFLIYRKLKLEKELAGMLWRVQWEDLQ 457

HSP 3 Score: 73.9442 bits (180), Expect = 8.226e-13
Identity = 57/198 (28.79%), Postives = 86/198 (43.43%), Query Frame = 3

Query:  264 AMLMLPKNFSMFPW--PLTIPAIKIALE----KVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY--LTQEFEITVDYWPI---RQYKE 824
            A +MLP N+  +PW  P   PA+ +A E    K K +      + +  T  P        + A    V   +   PDV FGP C Y LA + R ++ W +P+++ G   YGF  E+  E+KT+ RIG       LG  +     ++ WT    +       +  P Y  + G +  L  E  +TV   P    + YKE
Sbjct:   36 AAVMLPDNYHKYPWALPRVFPALLMAQEDLHTKHKLLLGHTITILNYSTENPAAPGSCAESRAQVVVVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGF--EKLDEYKTIVRIGPSTTK--LGAFVNVLHTQFNWTSRAVVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKE 229

[Close]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Match: npr2 (natriuretic peptide receptor 2 [Source:NCBI gene;Acc:100049183])

HSP 1 Score: 589.341 bits (1518), Expect = 0.000e+0
Identity = 297/513 (57.89%), Postives = 386/513 (75.24%), Query Frame = 3

Query: 2016 QLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNN-LGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGE 3551
            QLF KT  +KGN+VA+K + +++RI++ RQ+L+++K ++D+  +H+ RFIGAC++     +V +YCP+GSL+D+L  E I LDW+F+YSLI DI +GM +LHN+  G  G LKSSNC+VDSRFVLKITD+GL S R S +    +DS+  +   LWTAPELL   + P  GT KGDVYSF I+ QEI  R G F ++S D  S +EIV+ V+    P  FRP+ T     +E+  +L++  W EDP  RPDF  IK +M K NKEG S +IL+NLLSRMEQYANNLE++V+ERT+ YLEEK+KAE+LLY +LP SVA QL + + V AE++D VTI+FSDIVGFT++SAESTP+Q++ LLN LYT FD+II+N+DVYKVETIGDAYMV SGLP  NG LHAREIA M++A L  +  F I HRP+ +L+LRIGIH+GPVC+GVVGLKMPRYCLFGDTVNT+SRMESNG   KIH+S +T ++L  F  F +  RG +E+KGKG  +TYWL GE
Sbjct:  544 QLFAKTGYFKGNLVAIKHV-NKKRIELTRQVLMELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDIVKGMNFLHNSYFGCHGNLKSSNCVVDSRFVLKITDYGLASFRSSCE---NDDSHALYAKKLWTAPELLIYDHHPPQGTQKGDVYSFGIILQEIALRNGPFYVESMD-LSPKEIVQKVRNGQRPY-FRPT-TDSRFHSEELTILMEGCWAEDPAERPDFGHIKIYMAKLNKEG-STSILNNLLSRMEQYANNLENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIASMSLALLEQVKTFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSSATKEVLDEFCYFNLELRGDVEMKGKGKMRTYWLLGE 1048

HSP 2 Score: 176.792 bits (447), Expect = 1.661e-44
Identity = 135/502 (26.89%), Postives = 227/502 (45.22%), Query Frame = 3

Query:  264 AMLMLPKNFSMFPW--PLTIPAIKIALE----KVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGY--LTQEFEITVDYWPI---RQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGE-YVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDM-DPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGY--DNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLE 1724
            A +MLP N+  +PW  P   PA+ +A E    K K +      + +  T  P        + A    V   +   PDV FGP C Y LA + R ++ W +P+++ G   YGF  E+  E+KT+ RIG     L  G  +     ++ WT    +       +  P Y  + G +  L  E  +TV   P    + YKE               L+  I     +  +C  P      ++K  Q    + E Y    + +F+     + PW    + + + +   + ++S+  +T   P+N ++++F  ++   A R++  + E  L++    +FYDG +LYA AL++TLA+GGA +NG  I +   N +F G+ G V+ID    R  D  +  M + +TGE+  V+++ G+    +      + W S     P   P C +  D+  C      L I A+ +G+   +F IS    + +YR +KL+ EL  M W + WE L+
Sbjct:   36 AAVMLPDNYHKYPWALPRVFPALLMAQEDLHTKHKLLLGHTITILNYSTENPAAPGSCAESRAQVVVVDAKLYSRPDVFFGPGCVYPLASVGRFVSHWKLPLITAGGPAYGF--EKLDEYKTIVRIGPSTTKL--GAFVNVLHTQFNWTSRAVVIFYDLKQDDRPHYFLSEGIFMNLKDEMNMTVSARPYTNEQDYKE---------------LVSFIKENGRIIYIC-GPLETFLSIMKLFQSEIQDPESYAIFYLDVFAESLTHRKPW---QNAKFDWTNPIQVFKSVFVITYHPPDNPEYKDFQRKLHARAQRDFGVNLEPSLMDYIAGSFYDGFVLYAMALDETLAEGGAQNNGINITRRTQNRSFWGVTGLVSIDKRNARNIDVDLWAMTNQETGEYGVVSYYNGSTKEIVWSQTEKIHWPSCGP--PLDNPPCVFSTDDPSCNDGLPVLGIVAVGSGLALIIFGIS---SFLIYRKLKLEKELAGMLWRVQWEDLQ 509

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1)

HSP 1 Score: 2352.78 bits (6096), Expect = 0.000e+0
Identity = 1143/1147 (99.65%), Postives = 1147/1147 (100.00%), Query Frame = 3

Query:  156 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFLL 3596
            MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQN+KGTRNEMENLHLLHEVEKPSSK+SRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN+YFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDP+PKDAFLL
Sbjct:    1 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNVKGTRNEMENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDAFLL 1147

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000010241.1 (SMESG000010241.1)

HSP 1 Score: 2333.52 bits (6046), Expect = 0.000e+0
Identity = 1137/1147 (99.13%), Postives = 1140/1147 (99.39%), Query Frame = 3

Query:  156 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFLL 3596
            MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQN       MENLHLLHEVEKPSSK+SRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSN+YFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDP+PKDAFLL
Sbjct:    1 MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVKVHQSRSQN-------MENLHLLHEVEKPSSKISRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNVYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPVPKDAFLL 1140

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000056411.1 (SMESG000056411.1)

HSP 1 Score: 1412.9 bits (3656), Expect = 0.000e+0
Identity = 704/1162 (60.59%), Postives = 877/1162 (75.47%), Query Frame = 3

Query:  123 FPSRTEISFYNMLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNH--NCVKYQSKPIHNSKVKVHQSRSQNLKGTRNE------MENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKD 3584
            F S   + F+ +L   +IS    G E       Q C + RP+R YPLAML+LPKNFS FPW LTIP+IK+ LEKV+ M  +NPI+K++K L P+DS C++T+  LY  V  FV +MPDV+FGPIC YV+APIARL+AFWN P+++TGA+YY F  +R +EF TLTR+GSGHLD   G +I + F KYKW  G YI+ K AY + IP+YCH LG YL +     V  WPI+ Y EL    + ND+ ++  LI+ IGNK A+ +LC DP  V +I+L+A  LNF NGEY+F+NI +FSS +  + PWY       EN  AK+A+R+L+++TL+ PE EK++ FS +VK  A  EYN+  E +L+N+FVS+F+D V+LYA  LN TL+ GG I +G L++KNMWN +FE +G TVTI   GDR ADFS++D++ +TG F+ V+++IG K  +  V +  +DWG+V+N IP   P CGYD S CPKP    NIGAISAGVMG    I+   G F++R  K QAELNAMNWIIPW+ LETSEK R   +   N   Y  K   N    ++++  +NL  T+++      +EN +L+ +++    K  + N     N    D   IS  SL+TI GINLD +   QLF KTAL+KGN+VALKPI    +I+I  +LLI++KK+KD++NDHICRFIG CL+  + Y+VY+YCPKGSLEDVLAKEQI LDW+FKYSL+QDICRGM+YLHNN GP G LKSSNCLVDSRFVLKITDFGL SL+G+K  ++ E+ NMY+K+ LWTAPELL +SNPP++GT KGDVYSFA++CQEIVYR GVFSL  + + +++EI E V+ ++SP PFRP+L    GCT+D + LI+Q+W+EDP  RPDF TIK  MRK NK GD+GNILDNLLSRMEQYANNLE +V +RTEQYLEEK+KAEDLLYSMLPK VAHQLIKNQ V AESYD+VTIFFSDIVGFTALSAESTPMQII+LLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLH+REIARM+IAFL AI  F+IPHRPDK+L+LRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLP KIHISQST ++L TFGTF+++ERGHI++KGKG   TYWLHGE+  IVDP+P D
Sbjct:    3 FQSVKTMFFHCLLTGFIISLCREGSEA-LEKTNQGCDLVRPNRDYPLAMLLLPKNFSTFPWALTIPSIKMGLEKVRKMENINPIIKNIKILYPIDSDCLQTHKPLYESVINFVKEMPDVIFGPICDYVIAPIARLMAFWNRPVITTGALYYAFSSDRIAEFHTLTRVGSGHLDKYTGYLISELFSKYKWNKGKYIFFKDAYNSTIPMYCHGLGIYLVKGARKIVKNWPIKVYTELHPNDIKNDSTIDNMLIEQIGNKNAINILCADPDIVRKIMLRAASLNFINGEYLFLNIDIFSSQDIIERPWYRKDRPNEENEIAKKAFRTLMTITLRKPEGEKYKEFSAEVKRRAKMEYNFTDENELVNSFVSSFHDAVILYALGLNDTLSKGGKIEDGELVVKNMWNRSFESLGTTVTISPDGDRYADFSLMDLNQQTGMFEVVSNYIGRKRKYKPVNDKIIDWGTVNNKIPLDTPTCGYDLSGCPKP--GYNIGAISAGVMGAFVAIAIIGGVFIHRRTKFQAELNAMNWIIPWDDLETSEKRRRKFSDGDNFHPYTKKRFSNI---MNKNEMENLSLTKDDELKHESIENYYLMTDIDTSKKKKHKLNKLRRYNSYKDDESNISNKSLDTIIGINLDSMHKVQLFAKTALFKGNLVALKPINVNGKIEITTELLIEIKKIKDMSNDHICRFIGVCLD--HPYIVYEYCPKGSLEDVLAKEQIKLDWMFKYSLMQDICRGMIYLHNNHGPHGNLKSSNCLVDSRFVLKITDFGLPSLKGNKTNMMHEEPNMYYKSFLWTAPELLNLSNPPVNGTIKGDVYSFAVICQEIVYRNGVFSLTPDPNLTSKEIFEKVRNKDSP-PFRPTLMLTDGCTDDVLKLIQQAWDEDPTSRPDFATIKLLMRKLNKGGDTGNILDNLLSRMEQYANNLEGLVAKRTEQYLEEKQKAEDLLYSMLPKFVAHQLIKNQNVIAESYDMVTIFFSDIVGFTALSAESTPMQIIELLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHSREIARMSIAFLQAISIFIIPHRPDKKLELRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPLKIHISQSTKEILDTFGTFIISERGHIDLKGKGLQLTYWLHGEDSNIVDPLPVD 1155

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1)

HSP 1 Score: 1104.74 bits (2856), Expect = 0.000e+0
Identity = 587/1149 (51.09%), Postives = 766/1149 (66.67%), Query Frame = 3

Query:  159 LLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSM-FPWPLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQTFVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKV--KVHQSRSQNLKGTRNEME----NLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNP-PLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPK 3581
            L  +  SF VF   C+ +          PD  YPLA++M+P +    F   L + A  IALEK+++   ++P ++ LK     DS C+ +   LY  V+  +   P V FGPIC Y LAPIARLL FW+IPI++       FR+ +  E+ TLTR+ S  +   L  + +K F+ Y W+    IY +T        +C ++G     E            YK  T  ++    A     ID +G++ AV VLCV+P SV RILLKA +LNF NGEYVFINI L +S    + PWY        N +AK AYRSLL+VT + PE+E+++NF  +VK   + +Y    E    N F+  F+D +LLYA ALN T+A      NG+ I + MWN T +GI G ++ID +GDR AD+S+LDMD  TG FK VA++IG K  ++ V    +DW +  N+ P + P CGY+   CP  ++ +  G IS   M  + L +   G+++Y+ +K QAELNAMNW+IPW+++ET EK      H      S  + NS++  K  Q   + L     E +    N  L  +V K  S+ SR NS N           IS  S E+  G+  D +   + F  TALYKGNVVALK +   ++++INR LLI+VKKVK+LNN+HICRFIG CL+    +++ +YCPKGSL+D+L  EQI LDW+FK+SL+QDICRGM+YLH+N+GP G LKSSNCLVDSRFVLKI DFGL  LRG+K+YLLE D   Y++NLLWTAPE+LR +    L  + K DVYSF I+CQE+VYR GVF L S+ +   ++IVE V  +    P+RP L+    C+E    +I+QSW ED  LRPDF TIK  MR  NK GDSGNILDNLLSRMEQYANNLE++V +RTEQYLEEK+K EDLLYSMLPKSVA QLI+N+ V AESY++V+I+FSDIVGFTALSAESTPMQ+I+LLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARM++AFLSAIF F IPH+P+K ++LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIH+S+ ++ +L+TF  F++++RG + +KGKG   TYWLHGE+ +IVDPIP+
Sbjct:    9 LFILFYSFAVFIIICKSDITDNFPN-ANPD--YPLAIIMIPDDIRHNFNKNLMLSAFDIALEKIRTWN-IHPFIRKLKYYADADSDCLASRMPLYYTVKLLMKSKPGVWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLN-----FCRSVGTLFDSE-----------NYKNKTFKSVVLLNAETLLEID-MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCP--NRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK-----RHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVK--SRPSRVNSIN-----------ISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYL-SDINLEPKQIVEFV-TKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPE 1111

[Close]

BLAST of Guanylate cyclase vs. Planmine SMEST
Match: SMESG000068881.1 (SMESG000068881.1)

HSP 1 Score: 1066.22 bits (2756), Expect = 0.000e+0
Identity = 555/1042 (53.26%), Postives = 715/1042 (68.62%), Query Frame = 3

Query:  477 VLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEFKTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHALGGYLTQEFEITVDYWPIRQYKEXXXXXXXXXXXXEQFLIDAIGNKYAVAVLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASNQSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDLINTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGTVTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGSVSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFVYRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKV--KVHQSRSQNLKGTRNEME----NLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDLISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQLLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQITLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFGLISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNP-PLDGTFKGDVYSFAIVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCTEDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQYANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESYDLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVETIGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLRIGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQLLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPK 3581
            V FGPIC Y LAPIARLL FW+IPI++       FR+ +  E+ TLTR+ S  +   L  + +K F+ Y W+    IY +T        +C ++G     E            YK  T  ++    A     ID +G++ AV VLCV+P SV RILLKA +LNF NGEYVFINI L +S    + PWY        N +AK AYRSLL+VT + PE+E+++NF  +VK   + +Y    E    N F+  F+D +LLYA ALN T+A      NG+ I + MWN T +GI G ++ID +GDR AD+S+LDMD  TG FK VA++IG K  ++ V    +DW +  N+ P + P CGY+   CP  ++ +  G IS   M  + L +   G+++Y+ +K QAELNAMNW+IPW+++ET EK      H      S  + NS++  K  Q   + L     E +    N  L  +V K  S+ SR NS N           IS  S E+  G+  D +   + F  TALYKGNVVALK +   ++++INR LLI+VKKVK+LNN+HICRFIG CL+    +++ +YCPKGSL+D+L  EQI LDW+FK+SL+QDICRGM+YLH+N+GP G LKSSNCLVDSRFVLKI DFGL  LRG+K+YLLE D   Y++NLLWTAPE+LR +    L  + K DVYSF I+CQE+VYR GVF L S+ +   ++IVE V  +    P+RP L+    C+E    +I+QSW ED  LRPDF TIK  MR  NK GDSGNILDNLLSRMEQYANNLE++V +RTEQYLEEK+K EDLLYSMLPKSVA QLI+N+ V AESY++V+I+FSDIVGFTALSAESTPMQ+I+LLNRLYTTFDSIIE++DVYKVETIGDAYMVCSGLPQ NG++H REIARM++AFLSAIF F IPH+P+K ++LRIGIHSGPVC+GVVGLKMPRYCLFGDTVNT+SRMESNGLP KIH+S+ ++ +L+TF  F++++RG + +KGKG   TYWLHGE+ +IVDPIP+
Sbjct:   53 VWFGPICDYSLAPIARLLPFWDIPIITPCGASGIFRQMKHEEYSTLTRVNSIIVTDHLKVLFRKIFQMYNWSRVKLIYEQTFLN-----FCRSVGTLFDSE-----------NYKNKTFKSVVLLNAETLLEID-MGSENAVVVLCVEPESVRRILLKAHKLNFINGEYVFINIDLLTSKTNNQKPWYSKNDTDEVNFKAKEAYRSLLTVTAQRPESEEYQNFIKEVKNRTNEKYGSVEES---NKFLGVFHDSLLLYALALNDTMAMNLTYENGTFITRKMWNRTIQGITGEMSIDENGDRNADYSVLDMDKDTGIFKIVANYIGKKQLYIPVEGQIIDWVNKKNLPPPSFPVCGYNRKNCP--NRKIGAGTISLITMAAILLFALINGFYIYKRVKFQAELNAMNWLIPWDNVETREK-----RHRLTHKVSDTLPNSELFTKRFQYSKRGLAKFDEESDVLIGNPSLAGDVVK--SRPSRVNSIN-----------ISINSWESFTGLQNDNLHCIKTFITTALYKGNVVALKQLHGSKKVEINRNLLIEVKKVKNLNNEHICRFIGVCLDAPQHWLLTEYCPKGSLQDILENEQINLDWMFKFSLLQDICRGMIYLHSNIGPHGNLKSSNCLVDSRFVLKICDFGLEKLRGTKEYLLENDEYAYYRNLLWTAPEILRKTTEIHLQKSTKADVYSFGIICQEVVYRNGVFYL-SDINLEPKQIVEFV-TKVQLIPYRPFLSENEICSEGLCRIIRQSWQEDFSLRPDFRTIKGMMRYLNKGGDSGNILDNLLSRMEQYANNLEELVNQRTEQYLEEKRKTEDLLYSMLPKSVAGQLIRNETVTAESYEMVSIYFSDIVGFTALSAESTPMQVIELLNRLYTTFDSIIESFDVYKVETIGDAYMVCSGLPQRNGDIHIREIARMSLAFLSAIFEFQIPHKPNKRVELRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGLPLKIHMSEQSVDVLRTFQRFIISKRGQVNMKGKGYQTTYWLHGEDSVIVDPIPE 1052

The following BLAST results are available for this feature:

BLAST of Guanylate cyclase vs. Ensembl Human
BLAST of Guanylate cyclase vs. Ensembl Celegans
BLAST of Guanylate cyclase vs. Ensembl Fly
BLAST of Guanylate cyclase vs. Ensembl Zebrafish
BLAST of Guanylate cyclase vs. Ensembl Xenopus
BLAST of Guanylate cyclase vs. Ensembl Mouse
BLAST of Guanylate cyclase vs. UniProt/SwissProt
BLAST of Guanylate cyclase vs. TrEMBL
BLAST of Guanylate cyclase vs. Ensembl Cavefish
BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
BLAST of Guanylate cyclase vs. Ensembl Yeast
BLAST of Guanylate cyclase vs. Ensembl Nematostella
BLAST of Guanylate cyclase vs. Ensembl Medaka
BLAST of Guanylate cyclase vs. Planmine SMEST

BLAST of Guanylate cyclase vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR1	3.641e-58	58.72	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
NPR2	5.934e-47	56.89	natriuretic peptide receptor 2 [Source:HGNC Symbol...	[more]
GUCY2F	1.257e-131	47.42	guanylate cyclase 2F, retinal [Source:HGNC Symbol;...	[more]
GUCY2D	1.603e-130	45.18	guanylate cyclase 2D, retinal [Source:HGNC Symbol;...	[more]
GUCY2C	7.727e-117	45.33	guanylate cyclase 2C [Source:HGNC Symbol;Acc:HGNC:...	[more]

BLAST of Guanylate cyclase vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5


Match Name	E-value	Identity	Description
gcy-28	2.731e-61	50.69	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	3.199e-56	50.69	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	1.418e-180	50.69	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-28	2.551e-174	49.22	Receptor-type guanylate cyclase gcy-28 [Source:Un...	[more]
gcy-7	2.394e-141	31.35	Receptor-type guanylate cyclase gcy-7 [Source:Uni...	[more]

BLAST of Guanylate cyclase vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5


Match Name	E-value	Identity	Description
CG31183	0.000e+0	42.04	gene:FBgn0051183 transcript:FBtr0346151	[more]
CG31183	0.000e+0	42.04	gene:FBgn0051183 transcript:FBtr0083187	[more]
CG10738	1.073e-173	40.86	gene:FBgn0036368 transcript:FBtr0302487	[more]
CG10738	1.088e-172	40.52	gene:FBgn0036368 transcript:FBtr0302488	[more]
CG10738	2.884e-172	40.62	gene:FBgn0036368 transcript:FBtr0304792	[more]

BLAST of Guanylate cyclase vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1a	0.000e+0	39.63	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1a	0.000e+0	39.63	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1b	0.000e+0	39.10	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
npr1b	0.000e+0	44.81	natriuretic peptide receptor 1b [Source:ZFIN;Acc:Z...	[more]
si:dkey-37g12.1	0.000e+0	39.26	si:dkey-37g12.1 [Source:ZFIN;Acc:ZDB-GENE-090312-1...	[more]

BLAST of Guanylate cyclase vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5


Match Name	E-value	Identity	Description
NPR2	0.000e+0	57.77	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.77	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.77	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.77	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
NPR2	0.000e+0	57.77	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]

BLAST of Guanylate cyclase vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5


Match Name	E-value	Identity	Description
Npr1	2.880e-61	58.17	natriuretic peptide receptor 1 [Source:MGI Symbol;...	[more]
Npr2	0.000e+0	57.09	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Npr2	3.287e-48	57.09	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Npr2	1.606e-151	55.84	natriuretic peptide receptor 2 [Source:MGI Symbol;...	[more]
Gucy2g	1.516e-143	32.47	guanylate cyclase 2g [Source:MGI Symbol;Acc:MGI:10...	[more]

BLAST of Guanylate cyclase vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5


Match Name	E-value	Identity	Description
sp\|P16066\|ANPRA_HUMAN	1.748e-57	58.72	Atrial natriuretic peptide receptor 1 OS=Homo sapi...	[more]
sp\|P18293\|ANPRA_MOUSE	2.015e-60	58.17	Atrial natriuretic peptide receptor 1 OS=Mus muscu...	[more]
sp\|P18910\|ANPRA_RAT	2.961e-59	58.33	Atrial natriuretic peptide receptor 1 OS=Rattus no...	[more]
sp\|P16067\|ANPRB_RAT	2.071e-47	57.09	Atrial natriuretic peptide receptor 2 OS=Rattus no...	[more]
sp\|Q6VVW5\|ANPRB_MOUSE	2.299e-47	57.09	Atrial natriuretic peptide receptor 2 OS=Mus muscu...	[more]

BLAST of Guanylate cyclase vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5


Match Name	E-value	Identity	Description
G4V651	0.000e+0	48.52	Guanylate cyclase OS=Schistosoma mansoni OX=6183 G...	[more]
A0A1I8HCY1	0.000e+0	46.51	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A267GXV3	0.000e+0	51.71	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A267GHM2	0.000e+0	51.60	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]
A0A267EU15	0.000e+0	51.60	Guanylate cyclase OS=Macrostomum lignano OX=282301...	[more]

BLAST of Guanylate cyclase vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5


Match Name	E-value	Identity	Description
npr1a	0.000e+0	38.64	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1b	1.269e-50	58.88	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1b	1.269e-50	58.88	atrial natriuretic peptide receptor 1-like [Source...	[more]
npr1a	4.476e-41	58.33	natriuretic peptide receptor 1a [Source:ZFIN;Acc:Z...	[more]
npr1b	1.774e-50	55.98	atrial natriuretic peptide receptor 1-like [Source...	[more]

BLAST of Guanylate cyclase vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5


Match Name	E-value	Identity	Description
ENSPMAT00000006352.1	8.298e-46	58.21	pep scaffold:Pmarinus_7.0:GL477176:19246:83539:-1 ...	[more]
NPR1	0.000e+0	54.79	natriuretic peptide receptor 1 [Source:HGNC Symbol...	[more]
ENSPMAT00000008976.1	6.035e-152	38.42	pep scaffold:Pmarinus_7.0:GL476454:105373:131710:-...	[more]
ENSPMAT00000008986.1	5.634e-138	48.58	pep scaffold:Pmarinus_7.0:GL476454:105373:128493:-...	[more]
ENSPMAT00000008942.1	1.039e-137	46.55	pep scaffold:Pmarinus_7.0:GL476454:59555:94399:-1 ...	[more]

BLAST of Guanylate cyclase vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 5


Match Name	E-value	Identity	Description
CDC5	9.375e-10	21.97	Polo-like kinase; controls targeting and activatio...	[more]
KIN1	2.161e-9	27.47	Serine/threonine protein kinase involved in regula...	[more]
STE11	1.523e-8	26.78	Signal transducing MEK kinase; involved in pheromo...	[more]
KIN2	4.097e-8	28.65	Serine/threonine protein kinase involved in regula...	[more]
CDC15	9.720e-8	23.53	Protein kinase of the Mitotic Exit Network; locali...	[more]

BLAST of Guanylate cyclase vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5


Match Name	E-value	Identity	Description
EDO30985	4.283e-167	52.02	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO34275	6.564e-167	52.01	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36203	9.242e-130	43.99	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO27923	1.713e-128	48.16	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]
EDO36204	1.126e-124	47.24	Guanylate cyclase [Source:UniProtKB/TrEMBL;Acc:A7...	[more]

BLAST of Guanylate cyclase vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5


Match Name	E-value	Identity	Description
olgc7	0.000e+0	39.82	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
olgc7	0.000e+0	38.33	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
olgc2	7.359e-51	57.45	membrane guanylyl cyclase [Source:NCBI gene;Acc:10...	[more]
npr2	2.415e-26	57.89	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]
npr2	1.661e-44	57.89	natriuretic peptide receptor 2 [Source:NCBI gene;A...	[more]

BLAST of Guanylate cyclase vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5


Match Name	E-value	Identity	Description
SMESG000010241.1	0.000e+0	99.65	SMESG000010241.1	[more]
SMESG000010241.1	0.000e+0	99.13	SMESG000010241.1	[more]
SMESG000056411.1	0.000e+0	60.59	SMESG000056411.1	[more]
SMESG000068881.1	0.000e+0	51.09	SMESG000068881.1	[more]
SMESG000068881.1	0.000e+0	53.26	SMESG000068881.1	[more]

Analyses

This transcript is derived from or has results from the following analyses


Analysis Name	Date Performed
Embryonic Stages	2016-07-25
Schmidtea mediterranea smed_20140614 BLASTX Human e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99	2016-08-08
Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL	2020-05-01
Schmidtea mediterranea Sexual smed_20140614 transcriptome	2016-07-25
Schmidtea mediteranean smed_20140614 Interproscan	2020-05-01
Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99	2020-05-08
Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST	2020-05-08

Sequences

The following sequences are available for this feature:

transcript sequence
protein sequence

transcript sequence

>SMED30018527 ID=SMED30018527|Name=Guanylate cyclase|organism=Schmidtea mediterranea sexual|type=transcript|length=3664bp
TCGATTTGATTGCTCACAATGATTAATAGCAATACTCGATTTTGATTGGC
CGATGGAGAACTCTCTAGAAATGGAATTGTTAATGGAATCAATGTTATCA
ATGTTCATTGGAATTTAGACATTTTCCCTCCAGAACTGAGATTTCGTTCT
ACAACATGCTTCTAAAAATTCTAATCTCATTTCTTGTGTTCGGATTCGAG
TGTCAATGCAATTCAGAAACCCAGCTTTGTACAATCAAACGTCCAGATCG
GATTTATCCGCTTGCCATGTTAATGCTACCGAAAAATTTCTCCATGTTTC
CTTGGCCGTTGACAATTCCAGCAATCAAAATTGCTTTGGAGAAAGTCAAA
AGTATGCCATACATGAATCCGATAGTGAAATCGTTAAAAACTTTGGAGCC
AGTAGATAGTATTTGCGTTGAAACCAATTATGCGTTATACAGAGGAGTCC
AAACGTTCGTGACTCAAATGCCAGATGTTCTGTTTGGTCCAATCTGTGGA
TATGTTCTTGCACCAATAGCTCGACTTCTTGCATTCTGGAATATACCGAT
TTTGTCTACAGGAGCAGTTTATTATGGATTTAGAAAAGAGAGAAAAAGTG
AATTTAAAACTCTAACAAGAATAGGCTCAGGCCATTTGGATCTTGTTCTG
GGTCAGATGATACAAAAGACATTTAAAAAGTATAAATGGACCCATGGAAT
ATACATCTACCACAAGACTGCGTATACCAATGTCATTCCACTTTATTGTC
ATGCTTTAGGGGGCTATTTGACCCAAGAATTCGAGATCACGGTTGACTAT
TGGCCAATCAGGCAATACAAAGAGCTGACTACGGCCACCTTGACAAATGA
CACAGCGTTAGAACAGTTCCTTATTGATGCGATTGGCAATAAGTATGCAG
TCGCCGTCCTGTGCGTTGATCCGGCTTCAGTTCATAGGATTCTCCTCAAA
GCCGATCAGCTCAATTTCAACAATGGCGAATATGTTTTCATTAATATCGG
TTTGTTTTCGAGTGGGAACGAAACAAAATACCCTTGGTACCTCACGGCAT
CAAATCAATCTGAAAATTCTCGAGCAAAGCGAGCTTATCGCTCTCTTTTA
TCAGTTACTCTGAAAATTCCAGAAAATGAAAAATTTCGCAACTTTTCCGA
CCAAGTAAAAGAAATGGCATCGAGGGAATACAATTATCATTACGAAAAAG
ACTTGATAAATACCTTTGTAAGCAATTTCTACGATGGAGTACTGCTGTAC
GCTCATGCTTTGAATAAAACATTGGCGGACGGGGGAGCCATCAGCAATGG
CAGTTTAATTATTAAGAATATGTGGAACACGACCTTTGAAGGTATCGGAG
GAACGGTAACAATTGACTCTTCTGGAGATAGGATAGCCGATTTTTCTATC
CTGGATATGGATCCTAAAACTGGAGAATTCAAACCAGTTGCCCATTTTAT
CGGAACGAAATCCTCATTCCTAGTCGTGCCGAATGTGAGCGTTGACTGGG
GCAGCGTCAGCAACGTGATACCGTCCACCAAACCGAGATGCGGATACGAC
AATTCCATGTGCCCAAAACCCGATAAGAATCTCAACATTGGAGCCATTTC
AGCCGGCGTCATGGGCTGCCTGTTCCTAATTTCATTTAGTGCCGGCTACT
TTGTTTACAGAAATATCAAATTACAAGCCGAACTAAATGCTATGAATTGG
ATAATTCCTTGGGAGTCACTGGAAACCTCGGAGAAGATCCGGAACTTGGT
GAACCACAATTGTGTCAAATATCAAAGCAAACCTATCCACAATAGCAAAG
TCAAAGTGCATCAATCAAGATCGCAAAATTTAAAGGGAACAAGAAATGAA
ATGGAAAATCTGCATTTACTACACGAGGTGGAGAAGCCTTCAAGTAAACT
TTCAAGGAATAATTCAAAAAATTTCGGTAACCCCATCTACAAGGATTTGG
ATCTAATCAGCTGTGCCTCATTGGAAACAATAGCGGGAATAAATCTGGAT
AAAATCCAAAATGCTCAACTATTTACGAAAACCGCTCTTTACAAAGGCAA
CGTCGTGGCATTGAAGCCGATCCTTAGCCAACGTAGAATTGATATTAATC
GCCAGCTGTTAATTCAAGTGAAAAAGGTTAAAGACTTGAATAATGATCAT
ATTTGCCGCTTCATTGGAGCGTGCTTGGAAATCGGGTACCAATACATGGT
TTATGATTATTGCCCCAAAGGGAGCCTGGAAGACGTTCTAGCAAAGGAAC
AAATCACTTTGGACTGGGTATTCAAATATTCCTTGATTCAGGATATTTGT
AGGGGAATGGTTTACCTTCACAATAACCTCGGACCGATAGGGACTCTCAA
GAGTTCCAATTGCTTGGTTGACTCTCGTTTCGTATTAAAAATTACGGATT
TTGGCTTGATCTCCCTGAGAGGAAGCAAACAATATCTGCTGGAGGAAGAC
TCGAATATGTATTTTAAAAATCTTTTGTGGACTGCGCCAGAACTTCTACG
GATGTCAAATCCTCCACTCGATGGCACTTTCAAAGGAGATGTTTACAGTT
TTGCAATTGTATGCCAAGAAATTGTGTATAGAAAAGGAGTTTTCTCCTTG
GATTCAGAAGACGATTTCTCAGCCCAAGAAATCGTCGAATCTGTCAAAGC
CGAAAACAGTCCAAATCCTTTTCGACCAAGTCTCACGGCCATACATGGTT
GCACTGAGGATTTTGTGCTGTTAATCAAACAGTCGTGGAATGAAGATCCA
GTTCTTAGGCCAGATTTCAATACCATTAAATATCACATGAGAAAATTTAA
CAAGGAAGGCGACAGTGGCAATATTCTGGATAATCTTCTTTCACGAATGG
AACAGTATGCCAACAATTTGGAAGACATTGTTCAAGAAAGAACCGAACAG
TATTTGGAAGAAAAGAAAAAAGCAGAAGATCTTCTCTATTCAATGTTACC
GAAATCGGTCGCCCACCAGTTAATTAAAAACCAGCCAGTAAATGCCGAGA
GCTATGATCTGGTGACGATTTTCTTCAGTGACATCGTCGGATTCACGGCT
TTATCTGCCGAGTCAACCCCGATGCAAATAATTGACTTACTTAATCGGCT
CTACACCACATTTGATTCCATAATTGAAAATTACGACGTGTACAAAGTTG
AAACGATTGGAGATGCGTATATGGTTTGTTCAGGTCTACCTCAATTAAAT
GGAAACCTTCATGCGAGAGAAATTGCAAGGATGGCCATTGCATTTCTCAG
TGCGATTTTCTGCTTCGTGATTCCTCATAGGCCGGACAAGGAGTTGAAAT
TACGAATCGGTATTCATTCAGGACCTGTTTGTTCTGGGGTTGTCGGTTTG
AAAATGCCAAGGTATTGCTTGTTTGGAGACACCGTCAACACTTCAAGTAG
AATGGAGAGCAACGGATTGCCCCACAAAATTCATATTAGCCAGAGCACCA
TGCAGTTACTGAAAACTTTCGGAACTTTTTTGATGACAGAAAGAGGTCAC
ATTGAAGTTAAAGGCAAAGGATCTACGCAAACTTACTGGCTACATGGGGA
AAACGAGCTTATTGTCGACCCAATTCCAAAAGACGCCTTTCTGCTGTAAA
GTTTCAAGGCTACGAGGTGGAGATTTGTTTGACAAATTCAATGTTATATT
TCAGATTTAATAAA

protein sequence of SMED30018527-orf-1

>SMED30018527-orf-1 ID=SMED30018527-orf-1|Name=SMED30018527-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1148bp
MLLKILISFLVFGFECQCNSETQLCTIKRPDRIYPLAMLMLPKNFSMFPW
PLTIPAIKIALEKVKSMPYMNPIVKSLKTLEPVDSICVETNYALYRGVQT
FVTQMPDVLFGPICGYVLAPIARLLAFWNIPILSTGAVYYGFRKERKSEF
KTLTRIGSGHLDLVLGQMIQKTFKKYKWTHGIYIYHKTAYTNVIPLYCHA
LGGYLTQEFEITVDYWPIRQYKELTTATLTNDTALEQFLIDAIGNKYAVA
VLCVDPASVHRILLKADQLNFNNGEYVFINIGLFSSGNETKYPWYLTASN
QSENSRAKRAYRSLLSVTLKIPENEKFRNFSDQVKEMASREYNYHYEKDL
INTFVSNFYDGVLLYAHALNKTLADGGAISNGSLIIKNMWNTTFEGIGGT
VTIDSSGDRIADFSILDMDPKTGEFKPVAHFIGTKSSFLVVPNVSVDWGS
VSNVIPSTKPRCGYDNSMCPKPDKNLNIGAISAGVMGCLFLISFSAGYFV
YRNIKLQAELNAMNWIIPWESLETSEKIRNLVNHNCVKYQSKPIHNSKVK
VHQSRSQNLKGTRNEMENLHLLHEVEKPSSKLSRNNSKNFGNPIYKDLDL
ISCASLETIAGINLDKIQNAQLFTKTALYKGNVVALKPILSQRRIDINRQ
LLIQVKKVKDLNNDHICRFIGACLEIGYQYMVYDYCPKGSLEDVLAKEQI
TLDWVFKYSLIQDICRGMVYLHNNLGPIGTLKSSNCLVDSRFVLKITDFG
LISLRGSKQYLLEEDSNMYFKNLLWTAPELLRMSNPPLDGTFKGDVYSFA
IVCQEIVYRKGVFSLDSEDDFSAQEIVESVKAENSPNPFRPSLTAIHGCT
EDFVLLIKQSWNEDPVLRPDFNTIKYHMRKFNKEGDSGNILDNLLSRMEQ
YANNLEDIVQERTEQYLEEKKKAEDLLYSMLPKSVAHQLIKNQPVNAESY
DLVTIFFSDIVGFTALSAESTPMQIIDLLNRLYTTFDSIIENYDVYKVET
IGDAYMVCSGLPQLNGNLHAREIARMAIAFLSAIFCFVIPHRPDKELKLR
IGIHSGPVCSGVVGLKMPRYCLFGDTVNTSSRMESNGLPHKIHISQSTMQ
LLKTFGTFLMTERGHIEVKGKGSTQTYWLHGENELIVDPIPKDAFLL*

Annotated Terms

The following terms have been associated with this transcript:

Vocabulary: **molecular function**
Term	Definition
GO:0016301	kinase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0004672	protein kinase activity
GO:0005524	ATP binding
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0016829	lyase activity

Vocabulary: **biological process**
Term	Definition
GO:0016310	phosphorylation
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0006468	protein phosphorylation
GO:0006182	cGMP biosynthetic process

Vocabulary: **Planarian Anatomy**
Term	Definition
PLANA:0000020	protonephridia
PLANA:0000043	dorsal ventral margin of the whole animal
PLANA:0000099	neuron
PLANA:0000240	body wall musculature
PLANA:0000418	head
PLANA:0002032	epidermal cell

Vocabulary: **INTERPRO**
Term	Definition
IPR001170	ANPR/GUC
IPR001054	A/G_cyclase
IPR001245	Ser-Thr/Tyr_kinase_cat_dom
IPR001828	ANF_lig-bd_rcpt
IPR018297	A/G_cyclase_CS
IPR000719	Prot_kinase_dom
IPR011009	Kinase-like_dom_sf
IPR028082	Peripla_BP_I
IPR029787	Nucleotide_cyclase

Vocabulary: **cellular component**
Term	Definition
GO:0016021	integral component of membrane
GO:0005622	intracellular
GO:0016020	membrane

InterPro

Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01


IPR Term	IPR Description	Source	Source Term	Source Description	Alignment
None	No IPR available	COILS	Coil	Coil	coord: 891..911
None	No IPR available	GENE3D	G3DSA:1.10.510.10		coord: 621..918 e-value: 1.1E-51 score: 177.6
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 162..464 e-value: 1.6E-105 score: 355.4
None	No IPR available	GENE3D	G3DSA:3.40.50.2300		coord: 53..413 e-value: 1.6E-105 score: 355.4
None	No IPR available	PANTHER	PTHR11920:SF300	ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1	coord: 49..532
None	No IPR available	PANTHER	PTHR11920	ADENYLATE AND GUANYLATE CYCLASES	coord: 49..532 coord: 617..1134
None	No IPR available	PANTHER	PTHR11920:SF300	ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1	coord: 617..1134
None	No IPR available	CDD	cd07302	CHD	coord: 953..1129 e-value: 1.14303E-66 score: 220.143
None	No IPR available	SIGNALP_EUK	SignalP-noTM	SignalP-noTM	coord: 1..20 score: 0.598
None	No IPR available	TMHMM	TMhelix		coord: 120..142
None	No IPR available	TMHMM	TMhelix		coord: 478..500
IPR001170	Adenylyl cyclase class-4/guanylyl cyclase	PRINTS	PR00255	NATPEPTIDER	coord: 248..266 score: 26.32 coord: 396..413 score: 53.12 coord: 110..128 score: 45.07 coord: 481..503 score: 20.11 coord: 358..376 score: 55.59
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	SMART	SM00044	cyc_6	coord: 918..1120 e-value: 1.6E-99 score: 346.6
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PFAM	PF00211	Guanylate_cyc	coord: 946..1131 e-value: 1.2E-65 score: 220.6
IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase	PROSITE	PS50125	GUANYLATE_CYCLASE_2	coord: 954..1084 score: 49.395
IPR029787	Nucleotide cyclase	GENE3D	G3DSA:3.30.70.1230		coord: 939..1131 e-value: 1.4E-73 score: 248.5
IPR029787	Nucleotide cyclase	SUPERFAMILY	SSF55073	Nucleotide cyclase	coord: 940..1129
IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	PFAM	PF07714	Pkinase_Tyr	coord: 630..875 e-value: 2.5E-32 score: 112.2
IPR001828	Receptor, ligand binding region	PFAM	PF01094	ANF_receptor	coord: 56..420 e-value: 7.3E-45 score: 153.6
IPR018297	Adenylyl cyclase class-4/guanylyl cyclase, conserved site	PROSITE	PS00452	GUANYLATE_CYCLASE_1	coord: 1061..1084
IPR000719	Protein kinase domain	PROSITE	PS50011	PROTEIN_KINASE_DOM	coord: 595..880 score: 22.209
IPR011009	Protein kinase-like domain superfamily	SUPERFAMILY	SSF56112	Protein kinase-like (PK-like)	coord: 629..880
IPR028082	Periplasmic binding protein-like I	SUPERFAMILY	SSF53822	Periplasmic binding protein-like I	coord: 45..464