Superoxide dismutase [Cu-Zn]

Overview
NameSuperoxide dismutase [Cu-Zn]
Smed IDSMED30018398
Length (bp)751
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Superoxide dismutase [Cu-Zn] (SMED30018398) t-SNE clustered cells

Violin plots show distribution of expression levels for Superoxide dismutase [Cu-Zn] (SMED30018398) in cells (dots) of each of the 12 neoblast clusters.

 

back to top


 

Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Superoxide dismutase [Cu-Zn] (SMED30018398) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Superoxide dismutase [Cu-Zn] (SMED30018398) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

back to top


 

Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

back to top
Anatomical Expression

PAGE et. al., 2020




SMED30018398

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 7

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
gutSMED30018398h1SMcG0022015 SmedASXL_019073SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult colorimetric in situ hybridization evidence
pigment cellSMED30018398h1SMcG0022015 SmedASXL_019073SmedAsxl_ww_GCZZ01PMID:29158443
He et al., 2017
whole organism asexual adult RNA-sequencing evidence
gutSMED30018398h1SMcG0022015 dd_Smed_v4_2329_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30018398h1SMcG0022015 dd_Smed_v4_2329_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018398h1SMcG0022015 Contig35302uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018398h1SMcG0022015 Contig35302newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
tail regionSMED30018398h1SMcG0022015 dd_Smed_v6_2329_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD1 (superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179])

HSP 1 Score: 114.775 bits (286), Expect = 2.293e-31
Identity = 64/158 (40.51%), Postives = 90/158 (56.96%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVVNLTEMKKS---VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
              KA+  ++G      + G++N  E K+S   V + G IKGL    +HGFH+H+FGD    C + G H+NP ++KHGGP D  RH GD GN+ A+  G   +   D++  L+G +  IGR  V+HE  D      N  +   G+AG R+ACGVIGIA 
Sbjct:    2 ATKAVCVLKGDGP---VQGIINF-EQKESNGPVKVWGSIKGLTEG-LHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD1 (superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGNC:11179])

HSP 1 Score: 110.538 bits (275), Expect = 5.332e-30
Identity = 57/131 (43.51%), Postives = 76/131 (58.02%), Query Frame = 1
Query:  256 EMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            E    V + G IKGL    +HGFH+H+FGD    C + G H+NP ++KHGGP D  RH GD GN+ A+  G   +   D++  L+G +  IGR  V+HE  D      N  +   G+AG R+ACGVIGIA 
Sbjct:    6 ESNGPVKVWGSIKGLTEG-LHGFHVHEFGDNTAGCTSAGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVVHEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ 135          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: CCS (copper chaperone for superoxide dismutase [Source:HGNC Symbol;Acc:HGNC:1613])

HSP 1 Score: 100.523 bits (249), Expect = 7.037e-25
Identity = 59/173 (34.10%), Postives = 92/173 (53.18%), Query Frame = 1
Query:  127 SLLIGT--SFLLCGAKSPYIQ-VNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            +LL GT    +L G  S  +Q +  A++ + G    + +   + LT   +  +I G I GL P  +HG H+HQ+GDL N C + G H+NP    HGGP D +RH GD GN+RA+  G       D   ++   +  IGR+ ++ E  D+        ++  G++G R+ACG+I
Sbjct:   45 ALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLT--PERCLIEGTIDGLEPG-LHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKV---WDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGII 211          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: CCS (copper chaperone for superoxide dismutase [Source:HGNC Symbol;Acc:HGNC:1613])

HSP 1 Score: 100.908 bits (250), Expect = 7.212e-25
Identity = 59/173 (34.10%), Postives = 92/173 (53.18%), Query Frame = 1
Query:  127 SLLIGT--SFLLCGAKSPYIQ-VNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            +LL GT    +L G  S  +Q +  A++ + G    + +   + LT   +  +I G I GL P  +HG H+HQ+GDL N C + G H+NP    HGGP D +RH GD GN+RA+  G       D   ++   +  IGR+ ++ E  D+        ++  G++G R+ACG+I
Sbjct:   64 ALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLT--PERCLIEGTIDGLEPG-LHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKV---WDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGII 230          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Match: SOD3 (superoxide dismutase 3 [Source:HGNC Symbol;Acc:HGNC:11181])

HSP 1 Score: 73.559 bits (179), Expect = 4.578e-15
Identity = 47/143 (32.87%), Postives = 72/143 (50.35%), Query Frame = 1
Query:  229 NIYGVVNLTEMKKSVIISGY--IKGLPP---STVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGI 624
             + GVV   ++     +  +  ++G P    S+    H+HQFGDL   C +TG HYNP    H       +H GDFGN  A   G +  +++   + L G +S +GRA V+H   D      N ++   G+AG R+AC V+G+
Sbjct:   77 RVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPH------PQHPGDFGNF-AVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGV 212          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-4 (Extracellular superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34461])

HSP 1 Score: 118.242 bits (295), Expect = 2.505e-32
Identity = 61/162 (37.65%), Postives = 89/162 (54.94%), Query Frame = 1
Query:  163 AKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
            A S  I+    I   +       + G ++  +    + ++G + GL     HGFHIH+ GD GN CL+ G HYNP+   HG P D NRH GD GN+ +   G+  I  SD+++ L+G+YS IGR+ V+HE  D+        ++  G+AG R+ACG IGI  
Sbjct:   17 AASEVIRARAYIFKAEAGKIPTELIGTIDFDQSGSFLKLNGSVSGLAAGK-HGFHIHEKGDTGNGCLSAGGHYNPHKLSHGAPDDSNRHIGDLGNIESPASGDTLISVSDSLASLSGQYSIIGRSVVIHEKTDDLGRGTSDQSKTTGNAGSRLACGTIGIVE 177          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-4 (Extracellular superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34461])

HSP 1 Score: 116.701 bits (291), Expect = 2.559e-32
Identity = 60/159 (37.74%), Postives = 88/159 (55.35%), Query Frame = 1
Query:  163 AKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIG 621
            A S  I+    I   +       + G ++  +    + ++G + GL     HGFHIH+ GD GN CL+ G HYNP+   HG P D NRH GD GN+ +   G+  I  SD+++ L+G+YS IGR+ V+HE  D+        ++  G+AG R+ACG IG
Sbjct:   17 AASEVIRARAYIFKAEAGKIPTELIGTIDFDQSGSFLKLNGSVSGLAAGK-HGFHIHEKGDTGNGCLSAGGHYNPHKLSHGAPDDSNRHIGDLGNIESPASGDTLISVSDSLASLSGQYSIIGRSVVIHEKTDDLGRGTSDQSKTTGNAGSRLACGTIG 174          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 113.235 bits (282), Expect = 2.982e-31
Identity = 59/156 (37.82%), Postives = 90/156 (57.69%), Query Frame = 1
Query:  187 NKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY---------SAQPVGDAGGRVACGVIGIA 627
            N+A++ ++G +    I+ +   +E  ++VI  G IKGL P  +HGFH+HQ+GD  N C++ G H+NP+ K HGGP    RH GD GN+ A   G   I  +D +  L G  + +GR+ V+H  +D+           ++  G+AG R ACGVI +A
Sbjct:    3 NRAVAVLRGETVTGTIW-ITQKSENDQAVI-EGEIKGLTPG-LHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIALA 155          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 113.235 bits (282), Expect = 2.982e-31
Identity = 59/156 (37.82%), Postives = 90/156 (57.69%), Query Frame = 1
Query:  187 NKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY---------SAQPVGDAGGRVACGVIGIA 627
            N+A++ ++G +    I+ +   +E  ++VI  G IKGL P  +HGFH+HQ+GD  N C++ G H+NP+ K HGGP    RH GD GN+ A   G   I  +D +  L G  + +GR+ V+H  +D+           ++  G+AG R ACGVI +A
Sbjct:    3 NRAVAVLRGETVTGTIW-ITQKSENDQAVI-EGEIKGLTPG-LHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIALA 155          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Match: sod-1 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Swiss-Prot;Acc:P34697])

HSP 1 Score: 114.005 bits (284), Expect = 3.482e-31
Identity = 59/156 (37.82%), Postives = 90/156 (57.69%), Query Frame = 1
Query:  187 NKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY---------SAQPVGDAGGRVACGVIGIA 627
            N+A++ ++G +    I+ +   +E  ++VI  G IKGL P  +HGFH+HQ+GD  N C++ G H+NP+ K HGGP    RH GD GN+ A   G   I  +D +  L G  + +GR+ V+H  +D+           ++  G+AG R ACGVI +A
Sbjct:   25 NRAVAVLRGETVTGTIW-ITQKSENDQAVI-EGEIKGLTPG-LHGFHVHQYGDSTNGCISAGPHFNPFGKTHGGPKSEIRHVGDLGNVEAGADGVAKIKLTDTLVTLYGPNTVVGRSMVVHAGQDDLGEGVGDKAEESKKTGNAGARAACGVIALA 177          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0089938)

HSP 1 Score: 116.316 bits (290), Expect = 5.413e-32
Identity = 70/174 (40.23%), Postives = 93/174 (53.45%), Query Frame = 1
Query:  145 SFLLCGAKSPYIQVN----KAISYIQG--HSKFKNIYGVVNLTEMK--KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            S  LC       Q      +AI+Y+ G   S    + G V  T+    ++V +   ++GL     HGFHIH+ GDL N C++ G HYNP    HGGP    RH GD GNL AN+ G I +  +D +  LTGK   IGR  V+HE  D+        ++  G+AGGR+ACGVIGI
Sbjct:    8 SLALCATICSAAQTRNMPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGK-HGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0433531)

HSP 1 Score: 116.316 bits (290), Expect = 5.413e-32
Identity = 70/174 (40.23%), Postives = 93/174 (53.45%), Query Frame = 1
Query:  145 SFLLCGAKSPYIQVN----KAISYIQG--HSKFKNIYGVVNLTEMK--KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            S  LC       Q      +AI+Y+ G   S    + G V  T+    ++V +   ++GL     HGFHIH+ GDL N C++ G HYNP    HGGP    RH GD GNL AN+ G I +  +D +  LTGK   IGR  V+HE  D+        ++  G+AGGR+ACGVIGI
Sbjct:    8 SLALCATICSAAQTRNMPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGK-HGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0089939)

HSP 1 Score: 116.316 bits (290), Expect = 5.413e-32
Identity = 70/174 (40.23%), Postives = 93/174 (53.45%), Query Frame = 1
Query:  145 SFLLCGAKSPYIQVN----KAISYIQG--HSKFKNIYGVVNLTEMK--KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            S  LC       Q      +AI+Y+ G   S    + G V  T+    ++V +   ++GL     HGFHIH+ GDL N C++ G HYNP    HGGP    RH GD GNL AN+ G I +  +D +  LTGK   IGR  V+HE  D+        ++  G+AGGR+ACGVIGI
Sbjct:    8 SLALCATICSAAQTRNMPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGK-HGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0110897)

HSP 1 Score: 116.701 bits (291), Expect = 1.135e-31
Identity = 70/175 (40.00%), Postives = 93/175 (53.14%), Query Frame = 1
Query:  142 TSFLLCGAKSPYIQVN----KAISYIQG--HSKFKNIYGVVNLTEMK--KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
             S  LC       Q      +AI+Y+ G   S    + G V  T+    ++V +   ++GL     HGFHIH+ GDL N C++ G HYNP    HGGP    RH GD GNL AN+ G I +  +D +  LTGK   IGR  V+HE  D+        ++  G+AGGR+ACGVIGI
Sbjct:    7 VSLALCATICSAAQTRNMPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGK-HGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Match: Sod3 (gene:FBgn0033631 transcript:FBtr0339489)

HSP 1 Score: 114.005 bits (284), Expect = 1.857e-30
Identity = 69/177 (38.98%), Postives = 96/177 (54.24%), Query Frame = 1
Query:  124 LSLLIGTSFLLCGAKSPYIQVNKAISYIQGHSKFKN--IYGVVNLTEMK--KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            L + +     +C A        +AI+Y+ G  +  N  + G V  T+    ++V +   ++GL     HGFHIH+ GDL N C++ G HYNP    HGGP    RH GD GNL AN+ G I +  +D +  LTGK   IGR  V+HE  D+        ++  G+AGGR+ACGVIGI
Sbjct:    5 LVVSLALCATICSAAQTRNMPIQAIAYLIGPVQSDNTQVKGNVTFTQNDCGQNVHVRVQLEGLKEGK-HGFHIHEKGDLTNGCISMGAHYNPDKVDHGGPDHEVRHVGDLGNLEANSTGIIDVTYTDQVITLTGKLGIIGRGVVVHELEDDLGLGNHTDSKKTGNAGGRIACGVIGI 180          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod1 (superoxide dismutase 1, soluble [Source:NCBI gene;Acc:30553])

HSP 1 Score: 124.02 bits (310), Expect = 3.586e-35
Identity = 69/157 (43.95%), Postives = 92/157 (58.60%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVV--NLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            VNKA+  ++G  +   + G V  N    KK V ++G I GL P   HGFH+H FGD  N C++ G H+NP++K HGGP D  RH GD GN+ A+  G   I   D +  L+G++S IGR  V+HE  D      N  +   G+AGGR+ACGVIGI  
Sbjct:    2 VNKAVCVLKGTGE---VTGTVYFNQEGEKKPVKVTGEITGLTPGK-HGFHVHAFGDNTNGCISAGPHFNPHDKTHGGPTDSVRHVGDLGNVTADASGVAKIEIEDAMLTLSGQHSIIGRTMVIHEKEDDLGKGGNEESLKTGNAGGRLACGVIGITQ 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 96.6709 bits (239), Expect = 1.778e-23
Identity = 47/136 (34.56%), Postives = 74/136 (54.41%), Query Frame = 1
Query:  232 IYGVVNLTEMKKS-VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            + GVV   ++ +   +I G I GL P   HG H+H+ GDL   C + G H+NP+ K+HG P D +RH GD GN+ A   G  +    D+  ++   +  IGR+ V+    D+        ++  G++G R+ACG+I
Sbjct:   93 VQGVVRFLQLSQDRCLIDGTIDGLSPGA-HGLHVHELGDLTQDCRSCGDHFNPFRKQHGAPQDSDRHVGDLGNISAGPDGRASFRLEDSQIKV---WDVIGRSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGII 224          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 95.1301 bits (235), Expect = 4.904e-23
Identity = 47/136 (34.56%), Postives = 73/136 (53.68%), Query Frame = 1
Query:  232 IYGVVNLTEMK-KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            + GVV   ++     +I G I GL P   HG H+H+ GDL   C + G H+NP+ K+HG P D +RH GD GN+ A   G  +    D+  ++   +  IGR+ V+    D+        ++  G++G R+ACG+I
Sbjct:   93 VQGVVRFLQLSHDRCLIDGTIDGLSPGA-HGLHVHELGDLTQDCRSCGDHFNPFRKQHGAPQDSDRHVGDLGNISAGPDGRASFRLEDSQIKV---WDVIGRSLVVDSGEDDLGRGNHPLSKTTGNSGERLACGII 224          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod3b (superoxide dismutase 3, extracellular b [Source:ZFIN;Acc:ZDB-GENE-030131-8743])

HSP 1 Score: 80.8777 bits (198), Expect = 2.975e-18
Identity = 61/189 (32.28%), Postives = 97/189 (51.32%), Query Frame = 1
Query:  124 LSLLIGTSFLLCGAKSPYIQVN-----KAISYIQGHSKFK----NIYGVVNLTEM--KKSVIISGYIKGLPPSTVH--GFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKS-DNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            L+ L+    L CG+ S     +     +A+  +Q +++ +     +YG +   +   K+ + ++  + GLP  +      HIH++GDL   C +TG HYNP N  H       +H GDFGN    NK    I +S ++ + L GK S +GR+ V+HE +D      N  +   G+AGGR+AC VIG+ N
Sbjct:   10 LAFLLSCHVLFCGSGSGLAYASNSDSLQAVCRMQPNTRLEPGMPRVYGHILFRQSGPKEKLSVTFRLYGLPADSQQPRAMHIHEYGDLSRGCDSTGGHYNPLNVNH------PQHPGDFGNFVPVNK---KIRQSLESPATLFGKLSIVGRSVVIHEGKDDLGRGGNVGSLLNGNAGGRLACCVIGLRN 189          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Match: sod3a (superoxide dismutase 3, extracellular a [Source:ZFIN;Acc:ZDB-GENE-050309-208])

HSP 1 Score: 63.929 bits (154), Expect = 6.160e-12
Identity = 45/121 (37.19%), Postives = 60/121 (49.59%), Query Frame = 1
Query:  289 IKGLPPS--TVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIA 627
            ++G P +   V   HIHQ+GDL   C+  G HYNP +  H     PN H GD GN     +G I         +L G  S +GRA V+HE  D+        ++  G+AG R+A  VIGI 
Sbjct:   82 LRGFPETDNQVRAIHIHQYGDLSQGCVTAGPHYNPQDVPH-----PN-HPGDMGNFMP-KQGLIRRFLKLPEVKLFGGQSVLGRAVVVHEKEDDLGMGADEESKRSGNAGRRIAGCVIGIT 195          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:549006])

HSP 1 Score: 104.76 bits (260), Expect = 1.189e-27
Identity = 59/141 (41.84%), Postives = 81/141 (57.45%), Query Frame = 1
Query:  229 NIYGVVNLTEMKKS-VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            ++ GVV+  +  +  V + G I GL     HGFHIH+FGD  N C++ G H+NP +K HG P D  RH GD GN+ A + G      +D++  L G +S IGR  V+HE  D      N  +   G+AGGR+ACGVIG+  
Sbjct:   13 DVKGVVHFQQQDEGPVTVEGKIYGLTDGK-HGFHIHEFGDNTNGCISAGPHFNPESKTHGAPEDAVRHVGDLGNVTAKD-GVAEFKLTDSLISLKGNHSIIGRCAVVHEKEDDLGKGGNDESLKTGNAGGRLACGVIGLCQ 151          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 94.3597 bits (233), Expect = 1.921e-22
Identity = 49/148 (33.11%), Postives = 80/148 (54.05%), Query Frame = 1
Query:  193 AISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            A++ + G    + +   +  +E   + II G + GL P  +HG H+H+FGD+ N C + G HYNP+   HGGP + +RH GD GN+ A + G  +    D   ++   Y  IGR+ V+ E  D+        ++  G++G R+A G+I
Sbjct:   88 AVAMMSGEGSIQGVVRFIQTSE--NTCIIEGTLDGLSPG-LHGIHVHEFGDISNGCESCGEHYNPHRNSHGGPGEDDRHVGDLGNIFAADNGRASFRLMDERLKV---YDIIGRSLVVDEGEDDLGHGCHPLSKITGNSGRRLASGII 229          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 69.707 bits (169), Expect = 1.157e-13
Identity = 35/108 (32.41%), Postives = 59/108 (54.63%), Query Frame = 1
Query:  193 AISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITI-HKSDNISRLTG 513
            A++ + G    + +   +  +E   + II G + GL P  +HG H+H+FGD+ N C + G HYNP+   HGGP + +R +   G     ++GE  + H    +S++TG
Sbjct:   88 AVAMMSGEGSIQGVVRFIQTSE--NTCIIEGTLDGLSPG-LHGIHVHEFGDISNGCESCGEHYNPHRNSHGGPGEDDRVYDIIGRSLVVDEGEDDLGHGCHPLSKITG 192          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: sh3rf2 (SH3 domain containing ring finger 2 [Source:Xenbase;Acc:XB-GENE-5763588])

HSP 1 Score: 68.1662 bits (165), Expect = 4.528e-13
Identity = 51/170 (30.00%), Postives = 82/170 (48.24%), Query Frame = 1
Query:  139 GTSFLLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPS---TVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIG 621
            G ++  C + SP  ++  +   + G   FK ++    L  +         ++G P     +    HIH +GDL N C + G HYNP +  H       +H GDFGN R  + G+I    ++  + L G +S IGR+ V+H+  D      N ++   G+AG R+AC +IG
Sbjct:   56 GIAYATC-SLSPSSKLEPSEVKVTGLVLFKQVFPSGTLEAIFD-------LEGFPTDANQSARAIHIHTYGDLTNGCDSAGGHYNPMSVDHP------QHPGDFGNFRVRD-GKIQKFFANLDATLFGPFSVIGRSVVVHKQADDLGKGNNQASLENGNAGKRLACCIIG 210          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:496429])

HSP 1 Score: 59.6918 bits (143), Expect = 5.110e-10
Identity = 32/95 (33.68%), Postives = 50/95 (52.63%), Query Frame = 1
Query:  355 FCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVIG 621
            F  + G HYNP+   HGGP + +RH GD GN+ A + G  +    D   ++   Y  IGR+ V+ E  D+        ++  G++G R+A G+I 
Sbjct:  131 FLYSCGEHYNPHRNSHGGPGEDDRHVGDLGNIFAADNGRASFRLMDERLKV---YDIIGRSLVVDEGEDDLGHGCHPLSKITGNSGRRLASGIIA 222          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Sod1 (superoxide dismutase 1, soluble [Source:MGI Symbol;Acc:MGI:98351])

HSP 1 Score: 117.087 bits (292), Expect = 1.786e-32
Identity = 58/128 (45.31%), Postives = 78/128 (60.94%), Query Frame = 1
Query:  265 KSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            + V++SG I GL     HGFH+HQ+GD    C + G H+NP++KKHGGP D  RH GD GN+ A   G   +   D +  L+G++S IGR  V+HE +D      N  +   G+AG R+ACGVIGIA 
Sbjct:   28 EPVVLSGQITGLTEGQ-HGFHVHQYGDNTQGCTSAGPHFNPHSKKHGGPADEERHVGDLGNVTAGKDGVANVSIEDRVISLSGEHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIAQ 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 102.064 bits (253), Expect = 1.662e-25
Identity = 59/168 (35.12%), Postives = 90/168 (53.57%), Query Frame = 1
Query:  139 GTSFLLCGAKSPYIQ-VNKAISYIQGHSKFKNIYGVVNLTEMKKSV-IISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            G   +L G  S  +Q +  A++ ++G     +I GVV   ++   + +I G I GL P  +HG H+HQ+GDL   C + G H+NP    HGGP D +RH GD GN+RA   G  T    D   ++   +  IGR+ V+ E  D+        ++  G++G R+ACG+I
Sbjct:   70 GRQAVLKGMGSSQLQNLGAAVAILEG---CGSIQGVVRFLQLSSELCLIEGTIDGLEPG-LHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 230          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 99.3673 bits (246), Expect = 7.577e-25
Identity = 54/152 (35.53%), Postives = 83/152 (54.61%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVVNLTEMKKSV-IISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            +  A++ ++G     +I GVV   ++   + +I G I GL P  +HG H+HQ+GDL   C + G H+NP    HGGP D +RH GD GN+RA   G  T    D   ++   +  IGR+ V+ E  D+        ++  G++G R+ACG+I
Sbjct:   40 LGAAVAILEG---CGSIQGVVRFLQLSSELCLIEGTIDGLEPG-LHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 184          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 100.138 bits (248), Expect = 8.889e-25
Identity = 54/149 (36.24%), Postives = 82/149 (55.03%), Query Frame = 1
Query:  193 AISYIQGHSKFKNIYGVVNLTEMKKSV-IISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            A++ ++G     +I GVV   ++   + +I G I GL P  +HG H+HQ+GDL   C + G H+NP    HGGP D +RH GD GN+RA   G  T    D   ++   +  IGR+ V+ E  D+        ++  G++G R+ACG+I
Sbjct:   82 AVAILEG---CGSIQGVVRFLQLSSELCLIEGTIDGLEPG-LHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 223          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Match: Ccs (copper chaperone for superoxide dismutase [Source:MGI Symbol;Acc:MGI:1333783])

HSP 1 Score: 94.7449 bits (234), Expect = 4.036e-23
Identity = 48/122 (39.34%), Postives = 68/122 (55.74%), Query Frame = 1
Query:  271 VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
             +I G I GL P  +HG H+HQ+GDL   C + G H+NP    HGGP D +RH GD GN+RA   G  T    D   ++   +  IGR+ V+ E  D+        ++  G++G R+ACG+I
Sbjct:   67 CLIEGTIDGLEPG-LHGLHVHQYGDLTRDCNSCGDHFNPDGASHGGPQDTDRHRGDLGNVRAEAGGRATFRIEDKQLKV---WDVIGRSLVIDEGEDDLGRGGHPLSKITGNSGKRLACGII 184          
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|P00443|SODC_HORSE (Superoxide dismutase [Cu-Zn] OS=Equus caballus OX=9796 GN=SOD1 PE=1 SV=2)

HSP 1 Score: 124.79 bits (312), Expect = 1.248e-34
Identity = 63/154 (40.91%), Postives = 94/154 (61.04%), Query Frame = 1
Query:  190 KAISYIQGHSKFKNIYGVVNLTEMKKS--VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIA 627
            KA+  ++G      ++GV++  + ++   V++ G+I+GL     HGFH+H+FGD    C   G H+NP +KKHGGP D  RH GD GN+ A+  G+  +   D++  L+GK+S IGR  V+HE +D      N  +   G+AG R+ACGVIGIA
Sbjct:    4 KAVCVLKGDGP---VHGVIHFEQQQEGGPVVLKGFIEGLTKGD-HGFHVHEFGDNTQGCTTAGAHFNPLSKKHGGPKDEERHVGDLGNVTADENGKADVDMKDSVISLSGKHSIIGRTMVVHEKQDDLGKGGNEESTKTGNAGSRLACGVIGIA 153          
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|P51547|SODE_HAECO (Extracellular superoxide dismutase [Cu-Zn] OS=Haemonchus contortus OX=6289 GN=SOD PE=2 SV=1)

HSP 1 Score: 125.561 bits (314), Expect = 1.514e-34
Identity = 68/158 (43.04%), Postives = 96/158 (60.76%), Query Frame = 1
Query:  181 QVNKAISYI----QGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVIGI 624
            +V KA +YI    +G +  K + G+++L +    V ++G + GL P  +HGFHIH+ GDLGN CL  G H+NP+   HG P D NRH GD GN+     G+  I  SD++  LTG+++ IGRA V+H   D+        ++  G+AG RVACGVIGI
Sbjct:   27 EVLKARAYIFEAVKGGNPAKTV-GIIDLVQTGTLVKMNGSVSGLQPG-LHGFHIHEKGDLGNGCLAAGAHFNPHKMMHGAPEDSNRHVGDLGNIETPKTGDTPILISDSVISLTGQHNVIGRAIVIHADMDDLGRGTSELSKTTGNAGARVACGVIGI 182          
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|O73872|SODC_DANRE (Superoxide dismutase [Cu-Zn] OS=Danio rerio OX=7955 GN=sod1 PE=2 SV=1)

HSP 1 Score: 124.02 bits (310), Expect = 2.707e-34
Identity = 69/157 (43.95%), Postives = 92/157 (58.60%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVV--NLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            VNKA+  ++G  +   + G V  N    KK V ++G I GL P   HGFH+H FGD  N C++ G H+NP++K HGGP D  RH GD GN+ A+  G   I   D +  L+G++S IGR  V+HE  D      N  +   G+AGGR+ACGVIGI  
Sbjct:    2 VNKAVCVLKGTGE---VTGTVYFNQEGEKKPVKVTGEITGLTPGK-HGFHVHAFGDNTNGCISAGPHFNPHDKTHGGPTDSVRHVGDLGNVTADASGVAKIEIEDAMLTLSGQHSIIGRTMVIHEKEDDLGKGGNEESLKTGNAGGRLACGVIGITQ 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|P09670|SODC_SHEEP (Superoxide dismutase [Cu-Zn] OS=Ovis aries OX=9940 GN=SOD1 PE=1 SV=2)

HSP 1 Score: 122.479 bits (306), Expect = 1.057e-33
Identity = 64/154 (41.56%), Postives = 87/154 (56.49%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIA 627
              KA+  ++G      + G +        V+++G I GL     HGFH+HQFGD    C + G H+NP +KKHGGP D  RH GD GN++A+  G   +   D +  L+G+YS IGR  V+HE  D      N  +   G+AGGR+ACGVIGIA
Sbjct:    2 ATKAVCVLKGDGP---VQGTIRFEAKGDKVVVTGSITGLTEGD-HGFHVHQFGDNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVKADKNGVAIVDIVDPLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGGRLACGVIGIA 151          
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Match: sp|P41963|SODE_BRUPA (Extracellular superoxide dismutase [Cu-Zn] OS=Brugia pahangi OX=6280 PE=2 SV=1)

HSP 1 Score: 123.635 bits (309), Expect = 1.212e-33
Identity = 66/147 (44.90%), Postives = 86/147 (58.50%), Query Frame = 1
Query:  214 HSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY---------SAQPVGDAGGRVACGVIGIA 627
            HS   NI G ++  + K S  ISG IKGL P  +HGFH+HQ+GD  N C++ G H+NPYNK HG P D  RH GD GN+ A   G   I  SD   +L G  S IGR+ V+H  +D+           +   G+AGGRVACG++ I+
Sbjct:   53 HSDNGNINGTIHFQQDKNSTTISGEIKGLTPG-LHGFHVHQYGDTTNGCISAGPHFNPYNKTHGDPTDEMRHVGDLGNIVAGADGTAHIDISDKHVQLLGPNSIIGRSLVVHADQDDLGKGVGDKKDESLKTGNAGGRVACGIVAIS 198          
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A1N6J3K7 (Superoxide dismutase, Cu-Zn family OS=Singulisphaera sp. GP187 OX=1882752 GN=SAMN05444166_4287 PE=4 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 2.332e-35
Identity = 63/150 (42.00%), Postives = 93/150 (62.00%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLG-NFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYSAQPVGDAGGRVACGVIGIAN 630
            V KA++ +    K  +++G ++ T+  K +++ G I+GL P  +HGFH+H+FGD G +  ++ G H+NP N  H GPH   RH GD GN+ AN+KG   I   D+   L+G +S IGR  ++H   D+  + P G AG RVACGVIG+A 
Sbjct:   37 VTKAVAVLHATKKGGDVHGKISFTQTPKGILVEGTIEGLTPG-LHGFHVHEFGDCGSDDAMSAGGHFNPTNMPHAGPHADKRHVGDLGNIEANDKGVAKIDLHDSAITLSGAHSIIGRGLIVHAKADDLKSAPAGAAGDRVACGVIGVAK 185          
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: J5Q2F4 (Superoxide dismutase [Cu-Zn] OS=Trichosporon asahii var. asahii (strain ATCC 90039 / CBS 2479 / JCM 2466 / KCTC 7840 / NCYC 2677 / UAMH 7654) OX=1186058 GN=A1Q1_06521 PE=3 SV=1)

HSP 1 Score: 131.339 bits (329), Expect = 1.816e-34
Identity = 71/153 (46.41%), Postives = 91/153 (59.48%), Query Frame = 1
Query:  193 AISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDL-GNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIAN 630
            AIS ++G S   N  G V  TE +K V ++G I GL P + HGFH+H+FGD+ G  CL TG HYNP+N+ HG P D  RH GD GN+ AN  G + +  +D   RL G  S +GR  VLH   D      N  ++  G+AG R+ACG IGI N
Sbjct:   13 AISVLKGAS---NATGHVIFTESEKGVHVTGTITGLEPLSTHGFHVHEFGDISGEGCLATGGHYNPFNQTHGAPEDKVRHAGDLGNVVANENGTVILDITDRQLRLRGARSIVGRGVVLHSGVDDLGRGNNTDSKKTGNAGSRLACGAIGIGN 162          
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: I1SWH9 (Cu-Zn superoxide dismutase (Fragment) OS=Stichopus japonicus OX=307972 GN=Cu/Zn SOD PE=2 SV=1)

HSP 1 Score: 128.257 bits (321), Expect = 1.263e-33
Identity = 64/151 (42.38%), Postives = 93/151 (61.59%), Query Frame = 1
Query:  190 KAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            +A+  +QG    + + G +  T+   SV ++G ++GL    +HGFHIHQFGD  N C + G H+NP  K HGGP D  RH GD GN+ A++ G  +++ +D I  L+G +S IGR+ V+HE  D+        ++  G+AGGR ACGVIGI
Sbjct:    4 QAVCVLQG----QTVSGTITFTQEGNSVTVTGEVRGLTRG-LHGFHIHQFGDNTNGCTSAGGHFNPTGKTHGGPADEERHVGDLGNVEADDNGVASVNITDTIISLSGPHSIIGRSLVVHEGVDDLGRGGHEQSKTTGNAGGRAACGVIGI 149          
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A224XZ27 (Putative cu/zn-superoxide dismutase (Fragment) OS=Panstrongylus lignarius OX=156445 PE=4 SV=1)

HSP 1 Score: 129.413 bits (324), Expect = 1.447e-33
Identity = 72/171 (42.11%), Postives = 102/171 (59.65%), Query Frame = 1
Query:  127 SLLIGTSFLLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIG 621
             +L+  + LL  A++   Q  KAI  ++G +   +I G V   +  + V ISG I GL     HGFH+H++GDL   C +TG+H+NPY K HG P D  RH GD GN+ AN++G  TI+ +DN+ +L G  + +GRA V+HE  D      N  +   G+AG R+ACGVIG
Sbjct:    6 QILLWVALLLTAARA---QDRKAIVLLKGDNP--DIKGNVTFHQKDRVVTISGTIIGLKEGK-HGFHVHEYGDLSGGCASTGSHFNPYKKHHGAPTDSERHVGDLGNIVANSQGIATINMADNVIQLDGPNNVVGRAIVVHEGVDDLGKGGNAESLKTGNAGARIACGVIG 170          
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Match: A0A267ES22 (Sod_Cu domain-containing protein (Fragment) OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig014161g1 PE=4 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 2.031e-33
Identity = 63/161 (39.13%), Postives = 95/161 (59.01%), Query Frame = 1
Query:  160 GAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGI 624
            GAKS +     A++Y+  H    N++GV++L +   +++ISG + GL  S  +GFHIH+ GDL   C     HYNPY K HG P D +RH GDFGN+   + G   +  +D+++ L    S +GR+ V+H   D+       S++  G+AG R+ACGVIG+
Sbjct:   17 GAKSCHAATRSAVAYLTPHGSGYNVFGVISLEQSGANLVISGNVTGLNASQQYGFHIHESGDLSTGCGGALGHYNPYGKDHGAPTDSDRHVGDFGNIVGGSDGVTRVSITDSVASLVNTESVLGRSIVIHAGVDDLGRGGHPSSKTTGNAGARMACGVIGV 177          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:103036754])

HSP 1 Score: 120.939 bits (302), Expect = 3.856e-34
Identity = 68/157 (43.31%), Postives = 92/157 (58.60%), Query Frame = 1
Query:  181 QVNKAISYIQGHSKFKNIYGVVNLTEMKKS-VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
             V+KA+  ++G  +   + G V   +   + V +SG I GL P  +HGFH+H FGD  N C++ G HYNPYNK HGGP D  RH GD GN+ A   G   I+  D +  L+G +S +GR  V+HE  D+        +   G+AGGR+ACGVIGIA 
Sbjct:    1 MVHKAVCVLKGTGE---VTGTVFFEQGDGAPVKVSGEITGLTPG-LHGFHVHAFGDNTNGCISAGPHYNPYNKTHGGPTDEIRHVGDLGNVTAGADGVAKINIEDKMLSLSGPHSIVGRTMVIHEKEDDLGKGGDEESLKTGNAGGRLACGVIGIAQ 153          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 106.301 bits (264), Expect = 9.036e-28
Identity = 54/159 (33.96%), Postives = 86/159 (54.09%), Query Frame = 1
Query:  160 GAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            GA      +  A++ + G  + + +   + L+E +   +I G I GL P   HG H+H+ GDL   CL+ G HYNP+ K+HGGP D  RH GD GN++A + G  T    D+  ++   +  IGR+ V+    D+        ++  G++G R+ACG+I
Sbjct:   12 GALEKQPDLGSAVAMMSGAGRVQGVVRFLQLSENR--CLIDGTIDGLDPG-AHGLHVHELGDLTQDCLSCGEHYNPFGKQHGGPADTERHVGDLGNVQAGSDGRATFRLEDSQLKV---WDVIGRSLVVDSGEDDLGRESHPLSKQTGNSGQRLACGII 164          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod3b (superoxide dismutase 3, extracellular b [Source:ZFIN;Acc:ZDB-GENE-030131-8743])

HSP 1 Score: 72.0182 bits (175), Expect = 4.241e-15
Identity = 56/143 (39.16%), Postives = 73/143 (51.05%), Query Frame = 1
Query:  232 IYGVVNLTEMKKSVIISGYIK--GLPPSTVH--GFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
            +YG V   +      +S   K  GLP S       HIHQ+GDL   C +TG HYNP    H     PN H GDFGN    N G+I     D+ + L G  S +GRA V+HE  D+        +   G+AGGR+AC VIG+++
Sbjct:   42 VYGQVLFKQSGPEGKLSIRFKLHGLPASDPQPRAIHIHQYGDLSQGCTSTGGHYNPLGYNH-----PN-HPGDFGNFTPRN-GKIR-RSVDSRATLFGGLSVLGRAVVIHEKEDDLGRGGDAGSLLHGNAGGRLACCVIGLSS 176          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Match: sod3a (superoxide dismutase 3, extracellular a [Source:ZFIN;Acc:ZDB-GENE-050309-208])

HSP 1 Score: 58.9214 bits (141), Expect = 2.926e-10
Identity = 48/148 (32.43%), Postives = 70/148 (47.30%), Query Frame = 1
Query:  223 FKNIYGVVNLTEMKKS--VIISGYIKGLPPS--TVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNI--SRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
               +YG V   +   S  V +   ++GLP +       HIHQ+GDL    +  G HYNP    H        H GD GN   +N    T+ +  N+  + L G  S +GRA V+HE  D+        ++  G+AG R+A  VIGI++
Sbjct:   54 LPQLYGQVLFRQFYPSGAVQVIVNLRGLPTNDKQERAIHIHQYGDLSEGFVTAGPHYNPLGVDHPS------HPGDLGNFFPSNG---TVRRRLNVQAATLFGGPSILGRAVVIHEKEDDLGLGSDEESKRSGNAGRRIAGCVIGISS 192          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Sea Lamprey
Match: ccs (copper chaperone for superoxide dismutase [Source:ZFIN;Acc:ZDB-GENE-050417-322])

HSP 1 Score: 87.0409 bits (214), Expect = 1.071e-20
Identity = 51/156 (32.69%), Postives = 80/156 (51.28%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKN-IYGVVNLTEMKK-SVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSA---IGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            +  A++ + G    +  + GVV   ++   +  I G + GL P   HG H+H+FGDL N C + G H+NP+   HG P DPN H GD GN+ A+  G  +   +      +GK      IGR+ V+ E  D+        ++  G++G  +ACG+I
Sbjct:   75 LGAAVAQLSGDGAVRGAVLGVVRFVQLSPLTCAIEGTVDGLSPGP-HGLHVHEFGDLTNGCFSCGGHFNPHRSNHGRPDDPNSHVGDLGNIIADEHGRASFRVN------SGKIKVGDIIGRSVVVDETADDLGRGTHPLSKVTGNSGLGLACGII 223          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Yeast
Match: SOD1 (Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex [Source:SGD;Acc:S000003865])

HSP 1 Score: 105.531 bits (262), Expect = 5.028e-29
Identity = 56/155 (36.13%), Postives = 86/155 (55.48%), Query Frame = 1
Query:  190 KAISYIQGHSKFKNIYGVVNLTEMKKS--VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
            +A++ ++G +    + GVV   +  +S    +S  I G  P+   GFHIH+FGD  N C++ G H+NP+ K HG P D  RH GD GN++ +  G       D++ +L G  S +GR+ V+H  +D+        +   G+AG R ACGVIG+ N
Sbjct:    3 QAVAVLKGDA---GVSGVVKFEQASESEPTTVSYEIAGNSPNAERGFHIHEFGDATNGCVSAGPHFNPFKKTHGAPTDEVRHVGDMGNVKTDENGVAKGSFKDSLIKLIGPTSVVGRSVVIHAGQDDLGKGDTEESLKTGNAGPRPACGVIGLTN 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO42041 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7S2P3])

HSP 1 Score: 118.627 bits (296), Expect = 1.506e-33
Identity = 66/157 (42.04%), Postives = 89/157 (56.69%), Query Frame = 1
Query:  181 QVNKAISYIQGHSKFKNIYGVVNLTEMKKS--VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYSA------QPVGDAGGRVACGVIGIA 627
             V + +  + G ++ K   GV++ T+        + G I GL     HGFHIH+FGD  N C + G HYNP+ K HG P D +RH GD GN+ A+  G   +  +D +  LTG+ S IGR+ V+HE  D+  A         G+AGGRVACGVIGIA
Sbjct:    1 MVIRGVCCLVGDNEVK---GVIHFTQQAPDGPCTLRGRITGLTEGK-HGFHIHEFGDNTNGCTSAGAHYNPHGKMHGAPEDKDRHLGDLGNIEADANGIADVSITDCLVSLTGQCSIIGRSLVVHEGMDDLGAGGHELSLTTGNAGGRVACGVIGIA 153          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO42040 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7S2P2])

HSP 1 Score: 115.546 bits (288), Expect = 2.431e-32
Identity = 62/153 (40.52%), Postives = 87/153 (56.86%), Query Frame = 1
Query:  190 KAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
            +A+  + G    K     V   E  K   I+G I+GL     HGFHIH +GD  N C++ G H+NP+ K+HGGP D NRH GD GN+ A + G+  I  +D +  L G++S +GR+ V+H   D+        ++  G AGGR+ACGVIGI  
Sbjct:    4 QAVCCMSGTEGVKGTIKFVQEAE-GKPCKITGTIEGLKAGN-HGFHIHVYGDNTNGCVSAGPHFNPFKKEHGGPSDENRHVGDLGNVVAGDDGKACIDMTDALVTLVGEHSVVGRSVVVHADEDDLGRGGHEDSKTTGHAGGRLACGVIGITQ 154          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Match: EDO43919 (Superoxide dismutase [Cu-Zn] [Source:UniProtKB/TrEMBL;Acc:A7RX84])

HSP 1 Score: 89.7373 bits (221), Expect = 6.773e-23
Identity = 49/120 (40.83%), Postives = 68/120 (56.67%), Query Frame = 1
Query:  289 IKGLPPSTVHGFHIHQFGDL-GNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY---------SAQPVGDAGGRVACGVI 618
            ++G+PP TVHGFHIH+ GD+    C +   H+NPY K H GP   +RH GD GN+ ++  G +     D++  L G  S IGR+ VLH  RD+           +   G+AG R+AC VI
Sbjct:    5 LRGVPPLTVHGFHIHKSGDIITKGCQSAKGHFNPYGKTHAGPRKRDRHVGDLGNVWSDYHGNVRTSFFDHMVSLYGPDSVIGRSIVLHAERDDLGRGIGEYRTGSLATGNAGARLACCVI 124          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: sod1 (superoxide dismutase 1 [Source:NCBI gene;Acc:101170534])

HSP 1 Score: 121.709 bits (304), Expect = 2.184e-34
Identity = 70/157 (44.59%), Postives = 91/157 (57.96%), Query Frame = 1
Query:  181 QVNKAISYIQGHSKFKNIYGVVNLTEMKKS--VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRD------NYSAQPVGDAGGRVACGVIGIA 627
             V KA+  ++G  +     GVVN  +   S  V ++G IKGL P   HGFHIH +GD  N C++ G H+NPYNK HGGP D  RH GD GN+ A +     I  +D + RL+G  S +GR  V+HE  D      N  +   G+AG R+ACGVIGIA
Sbjct:    1 MVLKAVCVLKGTGETN---GVVNFEQESDSAPVKVTGEIKGLTPGK-HGFHIHVYGDNTNGCVSAGPHFNPYNKNHGGPEDAERHVGDLGNVTAGDNNVAKIDITDKLIRLSGPDSIVGRTVVVHEKVDDLGKGGNDESLKTGNAGARLACGVIGIA 153          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:101157814])

HSP 1 Score: 92.8189 bits (229), Expect = 3.637e-22
Identity = 50/148 (33.78%), Postives = 77/148 (52.03%), Query Frame = 1
Query:  193 AISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYS------AQPVGDAGGRVACGVI 618
            A++ + G    + +   + L+E  K  +I G I GL P   HG H+H  GDL   C + G HYNP+ K+HGGP D  RH GD GN+ A   G  +    D+  ++   +  IGR+ V+    D+        ++  G++G R+A G+I
Sbjct:   84 AVAMLSGAGSIQGVVRFLQLSE--KHCLIDGTIDGLEPG-CHGLHVHTLGDLTQDCKSCGEHYNPFGKQHGGPGDSERHVGDLGNIVAGPDGRASFRLEDDQLKV---WDVIGRSLVVDGGEDDLGRGTHPLSKQTGNSGERLAFGII 225          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: ccs (copper chaperone for superoxide dismutase [Source:NCBI gene;Acc:101157814])

HSP 1 Score: 88.1965 bits (217), Expect = 1.826e-20
Identity = 44/127 (34.65%), Postives = 66/127 (51.97%), Query Frame = 1
Query:  184 VNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDN 564
            +  A++ + G    + +   + L+E  K  +I G I GL P   HG H+H  GDL   C + G HYNP+ K+HGGP D  RH GD GN+ A   G  +    D+  ++   +  IGR+ V+    D+
Sbjct:   81 LGAAVAMLSGAGSIQGVVRFLQLSE--KHCLIDGTIDGLEPGC-HGLHVHTLGDLTQDCKSCGEHYNPFGKQHGGPGDSERHVGDLGNIVAGPDGRASFRLEDDQLKV---WDVIGRSLVVDGGEDD 201          
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Match: sod3b (superoxide dismutase 3 [Source:NCBI gene;Acc:101169658])

HSP 1 Score: 77.411 bits (189), Expect = 6.551e-17
Identity = 58/170 (34.12%), Postives = 90/170 (52.94%), Query Frame = 1
Query:  139 GTSFLLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIAN 630
            GT +  C   SP   +   +  + G + FK  +G   L  + +   ++G+ +   P +    HIHQ+GDL   C++TG HYNPY   H     PN H GDFGN  A ++G I+  + ++ + L G  S +GRA V+HE  D+        +   G+AG R+AC VIG+++
Sbjct:   42 GTLYAACKV-SPSTSLPDDLPKVYGQALFKQDHGQGKLQVLLQ---LAGFPEDESPQS-RAIHIHQYGDLSQGCISTGGHYNPYGVDH-----PN-HPGDFGNFVA-HEGRIS-EQIESEATLFGGLSVLGRAVVVHETIDDLGQGGDVGSLLHGNAGRRLACCVIGMSS 198          
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000005021.1 (SMESG000005021.1)

HSP 1 Score: 340.117 bits (871), Expect = 4.087e-120
Identity = 166/169 (98.22%), Postives = 167/169 (98.82%), Query Frame = 1
Query:  124 LSLLIGTSFLLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYSAQPVGDAGGRVACGVIGIAN 630
            LSLLIGTS LLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNI+RLTGKYSAIGRAFVLHE RDNYSAQPVGDAGGRVACGVIGIAN
Sbjct:    7 LSLLIGTSILLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNIARLTGKYSAIGRAFVLHERRDNYSAQPVGDAGGRVACGVIGIAN 175          
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000051067.1 (SMESG000051067.1)

HSP 1 Score: 128.257 bits (321), Expect = 1.054e-36
Identity = 68/154 (44.16%), Postives = 93/154 (60.39%), Query Frame = 1
Query:  166 KSPYIQVNKAISYIQGHSKFK-NIYGVVNLTEMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNYSAQPVGDAGGRVACGVIGI 624
            KS      KAI  +  +S     I G + L +  K + I   I GL P+++HG HIH+FGDL   C   G HYNP+ K+HG P   +RH GD GN+ ++  G++TI K D + +LTG  S IGR+ +LH+  D Y  QP G+AGGR+AC VIG+
Sbjct:   32 KSQNEDSKKAICLMNQNSNLHLKISGQIELEQQNKIISIKINIYGLHPNSIHGLHIHEFGDLRESCNKAGAHYNPFQKRHGAPTSQDRHIGDLGNVVSDLHGKVTITKLDTVIKLTGINSVIGRSVILHKHEDKYPFQPSGNAGGRLACCVIGL 185          
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Match: SMESG000020880.1 (SMESG000020880.1)

HSP 1 Score: 114.39 bits (285), Expect = 1.043e-31
Identity = 57/125 (45.60%), Postives = 77/125 (61.60%), Query Frame = 1
Query:  271 VIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHGGPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEWRDNY------SAQPVGDAGGRVACGVIGIA 627
            V I   I GL P   HGFHIH+FGD  N C++ G HYNP+ K HG P D  RH GD GN+ A+  G++ +  +D +  L G  S IGR+ V+HE  D+       +++  G+AGGR+ACGV+GI 
Sbjct:   30 VEIDVEISGLTPGK-HGFHIHEFGDNTNGCISAGGHYNPHGKTHGAPCDEERHVGDLGNVTADASGKVKVTLTDKVMSLVGPLSIIGRSLVVHENEDDLGKGGHETSKTTGNAGGRLACGVVGIT 153          
The following BLAST results are available for this feature:
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
SOD12.293e-3140.51superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGN... [more]
SOD15.332e-3043.51superoxide dismutase 1 [Source:HGNC Symbol;Acc:HGN... [more]
CCS7.037e-2534.10copper chaperone for superoxide dismutase [Source:... [more]
CCS7.212e-2534.10copper chaperone for superoxide dismutase [Source:... [more]
SOD34.578e-1532.87superoxide dismutase 3 [Source:HGNC Symbol;Acc:HGN... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod-42.505e-3237.65Extracellular superoxide dismutase [Cu-Zn] [Sourc... [more]
sod-42.559e-3237.74Extracellular superoxide dismutase [Cu-Zn] [Sourc... [more]
sod-12.982e-3137.82Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
sod-12.982e-3137.82Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
sod-13.482e-3137.82Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Sw... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sod35.413e-3240.23gene:FBgn0033631 transcript:FBtr0089938[more]
Sod35.413e-3240.23gene:FBgn0033631 transcript:FBtr0433531[more]
Sod35.413e-3240.23gene:FBgn0033631 transcript:FBtr0089939[more]
Sod31.135e-3140.00gene:FBgn0033631 transcript:FBtr0110897[more]
Sod31.857e-3038.98gene:FBgn0033631 transcript:FBtr0339489[more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod13.586e-3543.95superoxide dismutase 1, soluble [Source:NCBI gene;... [more]
ccs1.778e-2334.56copper chaperone for superoxide dismutase [Source:... [more]
ccs4.904e-2334.56copper chaperone for superoxide dismutase [Source:... [more]
sod3b2.975e-1832.28superoxide dismutase 3, extracellular b [Source:ZF... [more]
sod3a6.160e-1237.19superoxide dismutase 3, extracellular a [Source:ZF... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
sod11.189e-2741.84superoxide dismutase 1 [Source:NCBI gene;Acc:54900... [more]
ccs1.921e-2233.11copper chaperone for superoxide dismutase [Source:... [more]
ccs1.157e-1332.41copper chaperone for superoxide dismutase [Source:... [more]
sh3rf24.528e-1330.00SH3 domain containing ring finger 2 [Source:Xenbas... [more]
ccs5.110e-1033.68copper chaperone for superoxide dismutase [Source:... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Sod11.786e-3245.31superoxide dismutase 1, soluble [Source:MGI Symbol... [more]
Ccs1.662e-2535.12copper chaperone for superoxide dismutase [Source:... [more]
Ccs7.577e-2535.53copper chaperone for superoxide dismutase [Source:... [more]
Ccs8.889e-2536.24copper chaperone for superoxide dismutase [Source:... [more]
Ccs4.036e-2339.34copper chaperone for superoxide dismutase [Source:... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P00443|SODC_HORSE1.248e-3440.91Superoxide dismutase [Cu-Zn] OS=Equus caballus OX=... [more]
sp|P51547|SODE_HAECO1.514e-3443.04Extracellular superoxide dismutase [Cu-Zn] OS=Haem... [more]
sp|O73872|SODC_DANRE2.707e-3443.95Superoxide dismutase [Cu-Zn] OS=Danio rerio OX=795... [more]
sp|P09670|SODC_SHEEP1.057e-3341.56Superoxide dismutase [Cu-Zn] OS=Ovis aries OX=9940... [more]
sp|P41963|SODE_BRUPA1.212e-3344.90Extracellular superoxide dismutase [Cu-Zn] OS=Brug... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A1N6J3K72.332e-3542.00Superoxide dismutase, Cu-Zn family OS=Singulisphae... [more]
J5Q2F41.816e-3446.41Superoxide dismutase [Cu-Zn] OS=Trichosporon asahi... [more]
I1SWH91.263e-3342.38Cu-Zn superoxide dismutase (Fragment) OS=Stichopus... [more]
A0A224XZ271.447e-3342.11Putative cu/zn-superoxide dismutase (Fragment) OS=... [more]
A0A267ES222.031e-3339.13Sod_Cu domain-containing protein (Fragment) OS=Mac... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sod13.856e-3443.31superoxide dismutase 1 [Source:NCBI gene;Acc:10303... [more]
ccs9.036e-2833.96copper chaperone for superoxide dismutase [Source:... [more]
sod3b4.241e-1539.16superoxide dismutase 3, extracellular b [Source:ZF... [more]
sod3a2.926e-1032.43superoxide dismutase 3, extracellular a [Source:ZF... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ccs1.071e-2032.69copper chaperone for superoxide dismutase [Source:... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 1
Match NameE-valueIdentityDescription
SOD15.028e-2936.13Cytosolic copper-zinc superoxide dismutase; detoxi... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 3
Match NameE-valueIdentityDescription
EDO420411.506e-3342.04Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
EDO420402.431e-3240.52Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
EDO439196.773e-2340.83Superoxide dismutase [Cu-Zn] [Source:UniProtKB/Tr... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 4
Match NameE-valueIdentityDescription
sod12.184e-3444.59superoxide dismutase 1 [Source:NCBI gene;Acc:10117... [more]
ccs3.637e-2233.78copper chaperone for superoxide dismutase [Source:... [more]
ccs1.826e-2034.65copper chaperone for superoxide dismutase [Source:... [more]
sod3b6.551e-1734.12superoxide dismutase 3 [Source:NCBI gene;Acc:10116... [more]
back to top
BLAST of Superoxide dismutase [Cu-Zn] vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 3
Match NameE-valueIdentityDescription
SMESG000005021.14.087e-12098.22SMESG000005021.1[more]
SMESG000051067.11.054e-3644.16SMESG000051067.1[more]
SMESG000020880.11.043e-3145.60SMESG000020880.1[more]
back to top
Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018398 ID=SMED30018398|Name=Superoxide dismutase [Cu-Zn]|organism=Schmidtea mediterranea sexual|type=transcript|length=751bp
CTTGTCCATTGTGCATTTCAAAGTGTTTCAAATACTGCGCTACTAGATTA
AAACGTGTCCGTATACCACTACAATATAAATTAAATCAACAAATAATACA
ATATCATGAAAACAAAAATATATCTTTCTTTATTAATTGGAACAAGCTTT
TTGTTATGTGGAGCAAAAAGTCCATATATTCAAGTTAACAAAGCCATTTC
ATACATTCAAGGACATAGTAAATTCAAAAATATCTATGGAGTAGTAAATC
TAACCGAAATGAAAAAATCCGTAATAATTTCTGGATATATTAAAGGTCTC
CCTCCGTCAACCGTTCACGGATTTCATATTCACCAATTTGGGGATCTTGG
TAACTTTTGTTTGAATACTGGAACTCATTATAACCCATATAACAAGAAAC
ACGGCGGACCGCATGATCCAAATAGGCATTTTGGGGATTTTGGGAATCTT
AGAGCTAACAACAAAGGGGAAATTACTATTCATAAATCCGACAACATTTC
AAGATTAACTGGAAAATACAGTGCAATCGGAAGAGCCTTCGTTTTGCACG
AATGGCGAGATAATTATTCAGCACAACCTGTTGGAGATGCTGGGGGAAGA
GTAGCTTGTGGAGTTATTGGAATAGCCAATTAAGGATGGAAACATTTTAT
GAATTATTCGATTTAAATGACTATTTACAATAATTTTCTGAGTTGCTTCA
GAAATTGAAAGAAGAAAGTTTATTTTCAATAAATTTATTAGGGAAAAAAA
A
back to top

protein sequence of SMED30018398-orf-1

>SMED30018398-orf-1 ID=SMED30018398-orf-1|Name=SMED30018398-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=176bp
MKTKIYLSLLIGTSFLLCGAKSPYIQVNKAISYIQGHSKFKNIYGVVNLT
EMKKSVIISGYIKGLPPSTVHGFHIHQFGDLGNFCLNTGTHYNPYNKKHG
GPHDPNRHFGDFGNLRANNKGEITIHKSDNISRLTGKYSAIGRAFVLHEW
RDNYSAQPVGDAGGRVACGVIGIAN*
back to top
Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000421tail
PLANA:0002032epidermal cell
PLANA:0002075pigment cell
Vocabulary: INTERPRO
TermDefinition
IPR036423SOD-like_Cu/Zn_dom_sf
IPR024134SOD_Cu/Zn_/chaperone
IPR001424SOD_Cu_Zn_dom
IPR018152SOD_Cu/Zn_BS
Vocabulary: biological process
TermDefinition
GO:0055114oxidation-reduction process
GO:0006801superoxide metabolic process
GO:0019430removal of superoxide radicals
GO:0072593reactive oxygen species metabolic process
Vocabulary: molecular function
TermDefinition
GO:0046872metal ion binding
GO:0004784superoxide dismutase activity
GO:0005507copper ion binding
GO:0008270zinc ion binding
GO:0016209antioxidant activity
GO:0016491oxidoreductase activity
Vocabulary: cellular component
TermDefinition
GO:0005634nucleus
GO:0005737cytoplasm
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR001424Superoxide dismutase, copper/zinc binding domainPRINTSPR00068CUZNDISMTASEcoord: 72..94
score: 58.27
coord: 108..117
score: 57.01
coord: 127..149
score: 43.21
IPR001424Superoxide dismutase, copper/zinc binding domainPFAMPF00080Sod_Cucoord: 41..171
e-value: 2.1E-40
score: 138.2
IPR001424Superoxide dismutase, copper/zinc binding domainCDDcd00305Cu-Zn_Superoxide_Dismutasecoord: 42..171
e-value: 1.11161E-44
score: 142.399
IPR036423Superoxide dismutase-like, copper/zinc binding domain superfamilyGENE3DG3DSA:2.60.40.200coord: 20..174
e-value: 4.6E-45
score: 155.3
IPR036423Superoxide dismutase-like, copper/zinc binding domain superfamilySUPERFAMILYSSF49329Cu,Zn superoxide dismutase-likecoord: 41..174
NoneNo IPR availablePANTHERPTHR10003:SF71SUPEROXIDE DISMUTASE [CU-ZN]coord: 26..173
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..20
score: 0.679
IPR024134Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperonePANTHERPTHR10003SUPEROXIDE DISMUTASE CU-ZN -RELATEDcoord: 26..173
IPR018152Superoxide dismutase, copper/zinc, binding sitePROSITEPS00332SOD_CU_ZN_2coord: 160..171
IPR018152Superoxide dismutase, copper/zinc, binding sitePROSITEPS00087SOD_CU_ZN_1coord: 72..82