WD_REPEATS_REGION domain-containing protein

Overview
NameWD_REPEATS_REGION domain-containing protein
Smed IDSMED30018395
Length (bp)2191
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of WD_REPEATS_REGION domain-containing protein (SMED30018395) t-SNE clustered cells

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30018395) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of WD_REPEATS_REGION domain-containing protein (SMED30018395) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for WD_REPEATS_REGION domain-containing protein (SMED30018395) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30018395

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 10

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
X1 cellSMED30018395SMESG000032761.1 SmedASXL_012290SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
X2 cellSMED30018395SMESG000032761.1 SmedASXL_012290SmedAsxl_ww_GCZZ01PMID:26114597
Zhu et al., 2015		FACS sorted cell population asexual adult RNA-sequencing evidence
cephalic gangliaSMED30018395SMESG000032761.1 dd_Smed_v4_10217_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
neoblastSMED30018395SMESG000032761.1 dd_Smed_v4_10217_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018395SMESG000032761.1 Contig46653newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018395SMESG000032761.1 Contig46653uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
parapharyngeal regionSMED30018395SMESG000032761.1 dd_Smed_v6_10217_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017		whole organism asexual adult RNA-sequencing evidence
zeta neoblastSMED30018395SMESG000032761.1 dd_Smed_v4_10217_0_1dd_Smed_v4PMID:28292427
Wurtzel et al., 2017		whole organism asexual adult single-cell RNA-sequencing evidence
neoblastSMED30018395SMESG000032761.1 SMED_20702_V2_1GPL14150_gene_modelsPMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
neoblastSMED30018395SMESG000032761.1 SMED_20702_V2_1GPL14150PMID:22385657
Wagner et al., 2012		whole organism asexual adult cDNA to DNA expression microarray evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: WDHD1 (WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170])

HSP 1 Score: 79.337 bits (194), Expect = 1.900e-14
Identity = 121/470 (25.74%), Postives = 187/470 (39.79%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKAT----DK--PVKWTDKGKWKAVVATTEWHPLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESN----------LLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN I I+R + D     D+ + V+F D +++    +      Y + D++  A+L+      E      A+   C                         L  SSW    EW + LP+   E +   CL GQ +A   T   +       GG+Q  V S+                 AGP        +VS  GH     +  ++ T    D+   V+  + GK K  +   +  PLPL   S L WIGFS  G    VDS+  VR L+  L +T        WTP+ N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N  D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  432 PFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQ---DNAIDVEFHDTSIH-HATHLSNTLNYTIADLSHEAILLACESTDE-----LASKLHC-------------------------LHFSSWDSSKEWIIDLPQ--NEDIEAICL-GQGWAAAATSALLLRLFT-IGGVQKEVFSL-----------------AGP--------VVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGD--PLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNT--------WTPICNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQIATEKG-------QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-NLAIKYASRSRKLILAQKL 812
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Match: WDHD1 (WD repeat and HMG-box DNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:23170])

HSP 1 Score: 78.9518 bits (193), Expect = 2.278e-14
Identity = 121/470 (25.74%), Postives = 187/470 (39.79%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKAT----DK--PVKWTDKGKWKAVVATTEWHPLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESN----------LLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN I I+R + D     D+ + V+F D +++    +      Y + D++  A+L+      E      A+   C                         L  SSW    EW + LP+   E +   CL GQ +A   T   +       GG+Q  V S+                 AGP        +VS  GH     +  ++ T    D+   V+  + GK K  +   +  PLPL   S L WIGFS  G    VDS+  VR L+  L +T        WTP+ N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N  D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  309 PFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQ---DNAIDVEFHDTSIH-HATHLSNTLNYTIADLSHEAILLACESTDE-----LASKLHC-------------------------LHFSSWDSSKEWIIDLPQ--NEDIEAICL-GQGWAAAATSALLLRLFT-IGGVQKEVFSL-----------------AGP--------VVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGD--PLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNT--------WTPICNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQIATEKG-------QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-NLAIKYASRSRKLILAQKL 689
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Match: ctf-4 (Chromosome Transmission Fidelity factor homolog [Source:UniProtKB/TrEMBL;Acc:Q19520])

HSP 1 Score: 67.3958 bits (163), Expect = 2.774e-11
Identity = 80/358 (22.35%), Postives = 149/358 (41.62%), Query Frame = 1 
Query:  166 GNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWSEWNVLLPRANREKVVGC--CLVGQMYAIVMTQK-CVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRL-------MWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGL---ATLEFQLPLC 1191
              ++ L +N   I+R++ +  N     + ++F + +++  +   +    YEL D++   + + S +  + +      +    + E ++ ++ E++      +HV P+       W+++LPR +     GC   L      +V+T+K  +R F    GGIQ  + + H  PI  A+                R+ I S  G           WR ++ + T  P  W  + +            +P+     L WI +S+ G+L  +DS   V   H+       +++   W P+    +AL      SD  FPIG+  +     F  + CRGSR    SP   G+    T+EF++P C
Sbjct:  453 ATQRFLKYNRFGIIRSYVNEANKVST-IDIEFHNKSIHGDIHIDNFEINYELADISLKVVALASVESRKKEKELDKANDDIEDLETDEPAKTEKKGTSL--LHVIPIQAFDSQRWSMVLPRGD-----GCIDVLCSNTQVVVLTKKRNIRVF--TIGGIQRQIFT-HFAPILTAACFED------------RLAIASVCGSEFYEQKKTPQWRFEVVEYTLNPKSWYRENRHHGSTGAVSRIDVPIETGEQLDWIAYSNQGKLAVMDSAYTV---HV-------LSAPGLWIPIFQGSSALRA---PSDAIFPIGLTVKE----FRYIYCRGSR----SPLVNGINAPTTVEFKVPFC 766
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Match: ctf-4 (Chromosome Transmission Fidelity factor homolog [Source:UniProtKB/TrEMBL;Acc:Q19520])

HSP 1 Score: 67.3958 bits (163), Expect = 2.774e-11
Identity = 80/358 (22.35%), Postives = 149/358 (41.62%), Query Frame = 1 
Query:  166 GNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWSEWNVLLPRANREKVVGC--CLVGQMYAIVMTQK-CVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRL-------MWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGL---ATLEFQLPLC 1191
              ++ L +N   I+R++ +  N     + ++F + +++  +   +    YEL D++   + + S +  + +      +    + E ++ ++ E++      +HV P+       W+++LPR +     GC   L      +V+T+K  +R F    GGIQ  + + H  PI  A+                R+ I S  G           WR ++ + T  P  W  + +            +P+     L WI +S+ G+L  +DS   V   H+       +++   W P+    +AL      SD  FPIG+  +     F  + CRGSR    SP   G+    T+EF++P C
Sbjct:  453 ATQRFLKYNRFGIIRSYVNEANKVST-IDIEFHNKSIHGDIHIDNFEINYELADISLKVVALASVESRKKEKELDKANDDIEDLETDEPAKTEKKGTSL--LHVIPIQAFDSQRWSMVLPRGD-----GCIDVLCSNTQVVVLTKKRNIRVF--TIGGIQRQIFT-HFAPILTAACFED------------RLAIASVCGSEFYEQKKTPQWRFEVVEYTLNPKSWYRENRHHGSTGAVSRIDVPIETGEQLDWIAYSNQGKLAVMDSAYTV---HV-------LSAPGLWIPIFQGSSALRA---PSDAIFPIGLTVKE----FRYIYCRGSR----SPLVNGINAPTTVEFKVPFC 766
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1665])

HSP 1 Score: 83.1889 bits (204), Expect = 6.986e-16
Identity = 97/339 (28.61%), Postives = 146/339 (43.07%), Query Frame = 1 
Query:  505 EWNVLLPRANREKVVGCCLVGQMYAIVMTQKC-VRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWN----------DSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            +W V LP+   E V   CL GQ +A V T    VR F  + GG+Q  + S+ G  + +A     L+                 + +      D  +A    V+    G+ K  V   E  PLPLS    L W+GFS  G    VDS+  VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+G+R+P   P +  +A L F +P C      G       Q E Q+  +    N            DS S +     +  LLMK+F  +  L ++    ++  +M +S V+ LA++ A+R+ R  LA+++
Sbjct:  519 DWMVDLPKG--EDVRALCL-GQGWAAVATSALMVRLF--SIGGVQKEIFSLPGAVVCMAGHGEQLL-----------------IAYHRGTGFDGEQALG--VQLLQLGRKKRQVIHGE--PLPLSRKSYLAWMGFSAEGTPCCVDSEGVVRLLNRTLGNT--------WTPVCNTRETCKS---KSDHYWVVGVHENPQQLRC----IPCKGARFPPTLP-RPAVAVLPFNMPYCQTTTEKG-------QMEEQYWRSMLFHNHYGFLSSSGYEIDSESQAQAEKEQQELLMKMFALSCKLEREFRCVELAELMTHS-VVTLAIRYASRSRRMALAQRL 807
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1665])

HSP 1 Score: 83.1889 bits (204), Expect = 7.304e-16
Identity = 97/339 (28.61%), Postives = 146/339 (43.07%), Query Frame = 1 
Query:  505 EWNVLLPRANREKVVGCCLVGQMYAIVMTQKC-VRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWN----------DSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            +W V LP+   E V   CL GQ +A V T    VR F  + GG+Q  + S+ G  + +A     L+                 + +      D  +A    V+    G+ K  V   E  PLPLS    L W+GFS  G    VDS+  VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+G+R+P   P +  +A L F +P C      G       Q E Q+  +    N            DS S +     +  LLMK+F  +  L ++    ++  +M +S V+ LA++ A+R+ R  LA+++
Sbjct:  502 DWMVDLPKG--EDVRALCL-GQGWAAVATSALMVRLF--SIGGVQKEIFSLPGAVVCMAGHGEQLL-----------------IAYHRGTGFDGEQALG--VQLLQLGRKKRQVIHGE--PLPLSRKSYLAWMGFSAEGTPCCVDSEGVVRLLNRTLGNT--------WTPVCNTRETCKS---KSDHYWVVGVHENPQQLRC----IPCKGARFPPTLP-RPAVAVLPFNMPYCQTTTEKG-------QMEEQYWRSMLFHNHYGFLSSSGYEIDSESQAQAEKEQQELLMKMFALSCKLEREFRCVELAELMTHS-VVTLAIRYASRSRRMALAQRL 790
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:Xenbase;Acc:XB-GENE-942652])

HSP 1 Score: 91.2781 bits (225), Expect = 2.544e-18
Identity = 123/465 (26.45%), Postives = 186/465 (40.00%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDN-DNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLS---ALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN + ++R + D  DN  D    V+F D +++   I+      + L DV++ A+L+      E      A+   C                         L  SSW    EW V +P+   E +   CL     A       +R F  + GG+Q  + S+ G  + +A          G  D LI   +V + G      M         V+  + GK K  V   E  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W PV N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  +N  D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  395 PFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQDNAID----VEFHDTSIHHA-IHLTNTLNHTLADVSQEAVLLACESTEE-----LASKLQC-------------------------LHFSSWDTSKEWIVDMPKG--ENIQAICLGQGWVACATNALLIRIF--SVGGVQKEMLSLFGPVVCMA----------GHGDQLI---VVYQRG------MGFDGDQCLGVQLLELGKKKKQVLHGE--PLPLSRKSYLSWLGFTAEGTPCYVDSEGIVRLLNRSLGDT--------WIPVCNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFTNHLDYLSKHGYECDENVKSEAQKMQQELLMKMFALSCKLEREFRCMELAEFMTQP-VMSLAIKYASRSKRLILAQRL 775
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:Xenbase;Acc:XB-GENE-942652])

HSP 1 Score: 91.2781 bits (225), Expect = 3.000e-18
Identity = 121/464 (26.08%), Postives = 186/464 (40.09%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN + ++R + D     D+ + V+F D +++   I+      + L DV++ A+L+      E      A+   C                         L  SSW    EW V +P+   E +   CL     A       +R F  + GG+Q  + S+ G  + +A          G  D LI   +V + G      M         V+  + GK K  V   E  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W PV N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  +N  D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  382 PFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQ---DNAIDVEFHDTSIHHA-IHLTNTLNHTLADVSQEAVLLACESTEE-----LASKLQC-------------------------LHFSSWDTSKEWIVDMPKG--ENIQAICLGQGWVACATNALLIRIF--SVGGVQKEMLSLFGPVVCMA----------GHGDQLI---VVYQRG------MGFDGDQCLGVQLLELGKKKKQVLHGE--PLPLSRKSYLSWLGFTAEGTPCYVDSEGIVRLLNRSLGDT--------WIPVCNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFTNHLDYLSKHGYECDENVKSEAQKMQQELLMKMFALSCKLEREFRCMELAEFMTQP-VMSLAIKYASRSKRLILAQRL 762
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:Xenbase;Acc:XB-GENE-942652])

HSP 1 Score: 91.2781 bits (225), Expect = 3.160e-18
Identity = 121/464 (26.08%), Postives = 186/464 (40.09%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN + ++R + D     D+ + V+F D +++   I+      + L DV++ A+L+      E      A+   C                         L  SSW    EW V +P+   E +   CL     A       +R F  + GG+Q  + S+ G  + +A          G  D LI   +V + G      M         V+  + GK K  V   E  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W PV N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  +N  D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  362 PFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQ---DNAIDVEFHDTSIHHA-IHLTNTLNHTLADVSQEAVLLACESTEE-----LASKLQC-------------------------LHFSSWDTSKEWIVDMPKG--ENIQAICLGQGWVACATNALLIRIF--SVGGVQKEMLSLFGPVVCMA----------GHGDQLI---VVYQRG------MGFDGDQCLGVQLLELGKKKKQVLHGE--PLPLSRKSYLSWLGFTAEGTPCYVDSEGIVRLLNRSLGDT--------WIPVCNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFTNHLDYLSKHGYECDENVKSEAQKMQQELLMKMFALSCKLEREFRCMELAEFM-TQPVMSLAIKYASRSKRLILAQRL 742
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:Xenbase;Acc:XB-GENE-942652])

HSP 1 Score: 90.8929 bits (224), Expect = 3.579e-18
Identity = 121/464 (26.08%), Postives = 186/464 (40.09%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN + ++R + D     D+ + V+F D +++   I+      + L DV++ A+L+      E      A+   C                         L  SSW    EW V +P+   E +   CL     A       +R F  + GG+Q  + S+ G  + +A          G  D LI   +V + G      M         V+  + GK K  V   E  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W PV N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  +N  D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  382 PFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQ---DNAIDVEFHDTSIHHA-IHLTNTLNHTLADVSQEAVLLACESTEE-----LASKLQC-------------------------LHFSSWDTSKEWIVDMPKG--ENIQAICLGQGWVACATNALLIRIF--SVGGVQKEMLSLFGPVVCMA----------GHGDQLI---VVYQRG------MGFDGDQCLGVQLLELGKKKKQVLHGE--PLPLSRKSYLSWLGFTAEGTPCYVDSEGIVRLLNRSLGDT--------WIPVCNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFTNHLDYLSKHGYECDENVKSEAQKMQQELLMKMFALSCKLEREFRCMELAEFMTQP-VMSLAIKYASRSKRLILAQRL 762
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Match: tab3 (TGF-beta activated kinase 1 (MAP3K7) binding protein 3 [Source:Xenbase;Acc:XB-GENE-942652])

HSP 1 Score: 90.8929 bits (224), Expect = 3.816e-18
Identity = 121/464 (26.08%), Postives = 186/464 (40.09%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN + ++R + D     D+ + V+F D +++   I+      + L DV++ A+L+      E      A+   C                         L  SSW    EW V +P+   E +   CL     A       +R F  + GG+Q  + S+ G  + +A          G  D LI   +V + G      M         V+  + GK K  V   E  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W PV N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  +N  D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  424 PFQSGSTPVHLMHRFMVWNSVGVIRCYNDEQ---DNAIDVEFHDTSIH-HAIHLTNTLNHTLADVSQEAVLLACESTEE-----LASKLQC-------------------------LHFSSWDTSKEWIVDMPKG--ENIQAICLGQGWVACATNALLIRIF--SVGGVQKEMLSLFGPVVCMA----------GHGDQLI---VVYQRG------MGFDGDQCLGVQLLELGKKKKQVLHGE--PLPLSRKSYLSWLGFTAEGTPCYVDSEGIVRLLNRSLGDT--------WIPVCNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFTNHLDYLSKHGYECDENVKSEAQKMQQELLMKMFALSCKLEREFRCMELAEFM-TQPVMSLAIKYASRSKRLILAQRL 804
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:2443514])

HSP 1 Score: 75.8702 bits (185), Expect = 1.458e-13
Identity = 69/219 (31.51%), Postives = 102/219 (46.58%), Query Frame = 1 
Query:  862 PLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            PLPL   S L W+GFS  G    VDS+ CVR L+  L +T        WTPV N+R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N+ D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  574 PLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNT--------WTPVCNIREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQTSTEKG-------QMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-HLAIKYASRSRKLILAQKL 768
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Match: Wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:MGI Symbol;Acc:MGI:2443514])

HSP 1 Score: 75.485 bits (184), Expect = 1.623e-13
Identity = 69/219 (31.51%), Postives = 102/219 (46.58%), Query Frame = 1 
Query:  862 PLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            PLPL   S L W+GFS  G    VDS+ CVR L+  L +T        WTPV N+R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N+ D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  611 PLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNT--------WTPVCNIREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQTSTEKG-------QMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-HLAIKYASRSRKLILAQKL 805
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|O13046|WDHD1_XENLA (WD repeat and HMG-box DNA-binding protein 1 OS=Xenopus laevis OX=8355 GN=wdhd1 PE=1 SV=1)

HSP 1 Score: 84.3445 bits (207), Expect = 2.232e-15
Identity = 99/345 (28.70%), Postives = 146/345 (42.32%), Query Frame = 1 
Query:  493 SSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            SSW    EW V +P+   E +   CL     A   +   +R F  + GG+Q  + S+ G  + +AS    L+                 V HR M   D  +     V+  + GK K  V   +  PLPLS    L W+GF+  G    VDS+  VR L+  L  T        W P+ N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F LP C      G       Q E Q+  +Q  SN +D  S      +E+           LLMK+F  +  L ++    ++   M    VM LA+K A+R+ R  LA+++
Sbjct:  508 SSWDTSKEWMVDMPKG--ENIQAICLGQGWVACATSALLIRIF--SVGGVQKELISLFGPVVCMASHGEQLIV----------------VYHRGMG-FDGDQCLG--VQLLELGKKKKQVLHGD--PLPLSRKSYLSWLGFTAEGSPCYVDSEGIVRLLNRSLGDT--------WVPICNTREHCKG---KSDHYWVVGIHENPQQVRC----IPCKGSRFPPTLP-RPAVAVLPFNLPYCQITTEKG-------QMEEQYWRSQIFSNHSDYLSKHGYECDENFKAEAQKMQQELLMKMFALSCKLEREFRCMELAEFM-TQNVMNLAIKYASRSKRLILAQRL 803
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|O75717|WDHD1_HUMAN (WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens OX=9606 GN=WDHD1 PE=1 SV=1)

HSP 1 Score: 79.337 bits (194), Expect = 9.122e-14
Identity = 121/470 (25.74%), Postives = 187/470 (39.79%), Query Frame = 1 
Query:  136 PIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKAT----DK--PVKWTDKGKWKAVVATTEWHPLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESN----------LLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            P +S   P     + ++WN I I+R + D     D+ + V+F D +++    +      Y + D++  A+L+      E      A+   C                         L  SSW    EW + LP+   E +   CL GQ +A   T   +       GG+Q  V S+                 AGP        +VS  GH     +  ++ T    D+   V+  + GK K  +   +  PLPL   S L WIGFS  G    VDS+  VR L+  L +T        WTP+ N R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N  D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  432 PFQSGSTPLHLTHRFMVWNSIGIIRCYNDEQ---DNAIDVEFHDTSIH-HATHLSNTLNYTIADLSHEAILLACESTDE-----LASKLHC-------------------------LHFSSWDSSKEWIIDLPQ--NEDIEAICL-GQGWAAAATSALLLRLFT-IGGVQKEVFSL-----------------AGP--------VVSMAGHGEQLFIVYHRGTGFDGDQCLGVQLLELGKKKKQILHGD--PLPLTRKSYLAWIGFSAEGTPCYVDSEGIVRMLNRGLGNT--------WTPICNTREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQIATEKG-------QMEEQFWRSVIFHNHLDYLAKNGYEYEESTKNQATKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-NLAIKYASRSRKLILAQKL 812
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Match: sp|P59328|WDHD1_MOUSE (WD repeat and HMG-box DNA-binding protein 1 OS=Mus musculus OX=10090 GN=Wdhd1 PE=1 SV=2)

HSP 1 Score: 75.485 bits (184), Expect = 1.154e-12
Identity = 69/219 (31.51%), Postives = 102/219 (46.58%), Query Frame = 1 
Query:  862 PLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            PLPL   S L W+GFS  G    VDS+ CVR L+  L +T        WTPV N+R        KSD Y+ +G+ +     RC    + C+GSR+P   P +  +A L F+LP C      G       Q E QF  +    N+ D  + +     ES           LLMK+   +  L ++    ++  +M  + V  LA+K A+R+ +  LA+K+
Sbjct:  611 PLPLTRKSYLTWLGFSAEGTPCYVDSEGCVRMLNRGLGNT--------WTPVCNIREHCKG---KSDHYWVVGIHENPQQLRC----IPCKGSRFPPTLP-RPAVAILSFKLPYCQTSTEKG-------QMEEQFWHSVLFHNYLDYLAKNGYDYEESIKNQAVKEQQELLMKMLALSCKLEREFRCVELADLMTQNAV-HLAIKYASRSRKLILAQKL 805
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A158QFG5 (WD_REPEATS_REGION domain-containing protein OS=Hymenolepis diminuta OX=6216 GN=HDID_LOCUS8819 PE=4 SV=1)

HSP 1 Score: 99.7525 bits (247), Expect = 1.310e-17
Identity = 128/523 (24.47%), Postives = 205/523 (39.20%), Query Frame = 1 
Query:  112 VDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDN---DNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSW-----SEWNVLLPRANREKVVGCCLVGQ-------MYAIVMTQKCVRYFMA-NAGGIQAYVESIHGNPIA---IASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGK---WKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLD------------------------------RANRCCFLAVQ---CRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLS----------NWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMG 1476
            V+K R   P  S   P     + L+WN + ++   F+N   D   D  + V+F D         +H     + GD     L M +     A       + S          E      + + + VRPLG         S+W+  LP  N E     CLV         +  +  + + +R+F+  +A G    ++ I   P+    I+     +++ A      I  V++      L WR  +Y  +      TD+G    W     ++ ++PLP+S    L W+GFSD+G LYT DS   +RR    L H G  A+   W P  + R  +    R +D +F +GV +                              R +   F  VQ   C+ SR+P   P +  ++TL F+LPLCG             + E  +L    L           + +++     LR+    LL +LF  A  L  D  A  +  MMP+   ++ A++ AA  NR+ LA+K+G
Sbjct:  449 VEKIRSFQPGSS---PEGFRERFLVWNHVGVVI-RFENEVEDGTTDASIEVEFHDTT-------FHHTIHLKTGDFTMADLSMTALMLASAGSTETPAEDS---------EEQAPNEADLSAIIVRPLGTGDLGSDTNSDWSARLP--NGESCRSVCLVSGDSDGSHGLAVVATSTRLLRFFLQPSASGSGGILQLIQATPLGLPPISLPGKDIVTMASHPTLPILTVVIGWSNEDLYWR--VYNLS------TDQGAPKGWLLGRLSSTFYPLPISPSAHLSWLGFSDAGNLYTHDSVGFLRR----LTHQG--ATDFHWIPTCDTRKCIKSRARSTDCFFVVGVTENVHQSLDGLKMNKNLLDDGEEYVDDNFQKAREDELGFGQVQAIYCKASRWPRPVP-RPIVSTLPFRLPLCGVLQSDQG------RLEENYLRTMMLDQRPFWGVPDEDLSENLKTDRLRSRRKTLL-RLFALAAKLESDWAALALVDMMPDLATVRYAIRYAANVNRQGLAQKVG 927
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A564XWR8 (WD_REPEATS_REGION domain-containing protein (Fragment) OS=Hymenolepis diminuta OX=6216 GN=WMSIL1_LOCUS542 PE=4 SV=1)

HSP 1 Score: 99.3673 bits (246), Expect = 1.368e-17
Identity = 128/523 (24.47%), Postives = 205/523 (39.20%), Query Frame = 1 
Query:  112 VDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDN---DNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSW-----SEWNVLLPRANREKVVGCCLVGQ-------MYAIVMTQKCVRYFMA-NAGGIQAYVESIHGNPIA---IASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGK---WKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLD------------------------------RANRCCFLAVQ---CRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLS----------NWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMG 1476
            V+K R   P  S   P     + L+WN + ++   F+N   D   D  + V+F D         +H     + GD     L M +     A       + S          E      + + + VRPLG         S+W+  LP  N E     CLV         +  +  + + +R+F+  +A G    ++ I   P+    I+     +++ A      I  V++      L WR  +Y  +      TD+G    W     ++ ++PLP+S    L W+GFSD+G LYT DS   +RR    L H G  A+   W P  + R  +    R +D +F +GV +                              R +   F  VQ   C+ SR+P   P +  ++TL F+LPLCG             + E  +L    L           + +++     LR+    LL +LF  A  L  D  A  +  MMP+   ++ A++ AA  NR+ LA+K+G
Sbjct:  449 VEKIRSFQPGSS---PEGFRERFLVWNHVGVVI-RFENEVEDGTTDASIEVEFHDTT-------FHHTIHLKTGDFTMADLSMTALMLASAGSTETPAEDS---------EEQAPNEADLSAIIVRPLGTGDLGSDTNSDWSARLP--NGESCRSVCLVSGDSDGSHGLAVVATSTRLLRFFLQPSASGSGGILQLIQATPLGLPPISLPGKDIVTMASHPTLPILTVVIGWSNEDLYWR--VYNLS------TDQGAPKGWLLGRLSSTFYPLPISPSAHLSWLGFSDAGNLYTHDSVGFLRR----LTHQG--ATDFHWIPTCDTRKCIKSRARSTDCFFVVGVTENVHQSLDGLKMNKNLLDDGEEYVDDNFQKAREDELGFGQVQAIYCKASRWPRPVP-RPIVSTLPFRLPLCGVLQSDQG------RLEENYLRTMMLDQRPFWGVPDEDLSENLKTDRLRSRRKTLL-RLFALAAKLESDWAALALVDMMPDLATVRYAIRYAANVNRQGLAQKVG 927
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A183IZ73 (Mcl1_mid domain-containing protein OS=Soboliphyme baturini OX=241478 GN=SBAD_LOCUS8921 PE=4 SV=1)

HSP 1 Score: 98.5969 bits (244), Expect = 1.577e-17
Identity = 109/459 (23.75%), Postives = 197/459 (42.92%), Query Frame = 1 
Query:  124 RPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRL--MWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWN-DSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
             P  P      P   + + L+WN I I++ +   ++   D   V+F D + +  L + + +  Y +GDV+  A+   SR   ++                                 V  +  SSW    EW+  LP  + E V   CL     A+V  ++ VR F+ +  G + Y+    GN +A+A  + +LM           V   + V +R     R  +Y+     V+ TD      V+       L L     L W+GF+  G   TVDS   VR L +         S   WTPVL L T       + D+ + +GV+++  +     + C+ S YP  +P +  + ++ +++PLC           +L  ++   + +  LSN + ++++++ L T E   L+KLF  A    +   A+DI  ++P++++++  +K A+R  R  LA+++
Sbjct:  197 EPRKPFMPGAMPERFSERYLMWNSIGIIKLYNSEEDSTID---VEFHDTSFHHSLHFSNTLTDYSIGDVSAEAVAFASRSSKDSRST------------------------------VNVIYFSSWDSSREWSSELP--DDESVECLCLGRNWLAVVTDKQLVRLFLLS--GTEIYLFEHPGNVLAVAGWNEFLM-----------VAYSTGVNYRGEGFTRCALYQ-----VRTTDWTAESPVIKKLHEFDLVLREAHHLVWMGFTKEGSPSTVDSDGTVRILSM---------SSLLWTPVLVLTTK-----HEDDKMWVVGVIEKPPQ--VRVILCKASEYPKIAP-RPPVLSIPWKIPLCDADTERSNNEHVLISSK---IASASLSNRSKNASNVASLNTTEIECLLKLFAMACKSERLHRAYDIAQLVPSAEMLQPFIKYASRVGRLVLADRV 582
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A2C9LR71 (HMG box domain-containing protein OS=Biomphalaria glabrata OX=6526 GN=106079003 PE=4 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 5.825e-17
Identity = 92/332 (27.71%), Postives = 146/332 (43.98%), Query Frame = 1 
Query:  505 EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLM-----SPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPL-PLSALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMG 1476
            EW   +P    E++          A+    + +R F  + GG+Q  V SI GN +A+AS S+ L+         P D  + V ++                          G+ + ++   +  PL P S L WIGFS+ G ++ +D    VR L+    +T        W+PV N +  +     KSD Y+ +GV +R    RC    V C+GSR+PA  P +  LA L FQLPLC             +++   +L  + LS++   +     +  ES  L+KLF  A   ++D  A ++  MM +  ++ LA   A R  R  LAE++ 
Sbjct:   78 EWFYTMPMG--EEIKAITATDTWVAVATELRNIRIF--SIGGLQRQVFSIPGNMVALASHSNQLVVVYHKGMGLPGDQHLGVSVICV-----------------------HGRSRKMLINGDSLPLSPKSKLSWIGFSEEGTVFYMDVDGVVRMLNKQFAYT--------WSPVANTKQHVKG---KSDHYWLVGVSERLQQIRC----VPCKGSRFPATLP-RPALAVLPFQLPLCEPESEKSQYEESYQRS---YLFAKSLSDYGMDSEDVNKQYRES--LIKLFAFAAKASRDFRALEVCDMMEDQSLLHLAATYATRLKRIQLAERVS 361
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Match: A0A2I4C262 (WD repeat and HMG-box DNA-binding protein 1 OS=Austrofundulus limnaeus OX=52670 GN=wdhd1 PE=4 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 3.101e-16
Identity = 121/447 (27.07%), Postives = 189/447 (42.28%), Query Frame = 1 
Query:  175 QILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCV-RYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXX-----XILRQTENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            + + WN + I+R + D     D+ + V+F D AV+  +   + +  + + D+++ A+L+      E      A+   C                         L  SSW    EW V LP+   E V   CL GQ +A V T   V R F  + GG+Q  + S+ G  + +A     L+                 V HR     D  +A    V+    G+ K  + + E  PLPLS    L W+GF+  G    VDS   VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+GSRYP   P +  +A L F+LPLC      G         +L      FL +       D+ + S  +  +  LLMK+F  +  L+++    ++  +M    V+ LA++ A+R+ R  LA+++
Sbjct:  329 RFMTWNSVGIVRGYNDEQ---DNAIDVEFHDTAVHHAMHLTNSLG-HTVADLSQEAVLLACPSTQE-----LASKLQC-------------------------LHFSSWDTNKEWMVDLPKG--EDVKALCL-GQGWAAVATSTMVLRLF--SIGGVQRELFSLPGPVVCVAGHGEQLLI----------------VYHRATG-FDGEQALG--VQLLQFGRRKRQLISGE--PLPLSHRSYLSWLGFTAEGTPCYVDSDGVVRMLNRSLGNT--------WTPVCNTRETCKS---KSDHYWVVGVHENPQQLRC----IPCKGSRYPPTLP-RPAVAILPFKLPLCQTSTEKGQMEEQYWRSVLFHNHYNFLSSNGYEVSEDAKTES--QKEQQELLMKMFALSCKLDREFRCVELADLM-TQNVVTLAIRYASRSRRMVLAQRL 696
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:ZFIN;Acc:ZDB-GENE-030131-1665])

HSP 1 Score: 77.0258 bits (188), Expect = 4.480e-14
Identity = 99/344 (28.78%), Postives = 145/344 (42.15%), Query Frame = 1 
Query:  493 SSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKCV-RYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESNL----------LMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            SSW    EW V LP+   E+V   CL G+ +A V T   + R F  + GG+Q  + S+ G  + +A     L+             IV   G        +       V+    G  K  V   E  PLPLS    L W+GFS  G   +VDS   VR L+  + +T        WTP+ N R        KSD Y+ +G+ +   +     + C+GSR+P   P +  ++ L F LP C      G       Q E Q+  +    N     S S    NE N           LMK+F  +  L ++    ++  MM  S V+ LA++ A+R+ R  LA+K+
Sbjct:  491 SSWDSNKEWMVDLPKG--EEVRALCL-GRGWAAVGTSALLLRLF--SIGGVQREIFSLPGPVVCLAGHGEQLL-------------IVYHRGTGFNGDQSL------GVQLLQLGGRKRQVIGGE--PLPLSHKSYLSWVGFSAEGTPCSVDSDGVVRMLNRSMGNT--------WTPICNTRDNCKS---KSDHYWVVGIHENPQQ--LRCIPCKGSRFPPTLP-RPAVSILPFSLPFCQTSTEKG-------QMEEQYWRSVLFHNHFSFLSSSGYEVNEENQRQQEKEQQEALMKMFALSCKLEREFRCVELAEMMTQS-VVTLAIRYASRSRRMILAQKL 786
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Match: EDO44786 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RUQ2])

HSP 1 Score: 78.5666 bits (192), Expect = 4.296e-15
Identity = 88/331 (26.59%), Postives = 138/331 (41.69%), Query Frame = 1 
Query:  496 SWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQT---ENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            S  EW V +P     + +    VG  +A V T K +   +    GIQ  V S+ G  +A+             S +L ++V+    G+ L     +       VK  D    +  V          S L WIGFS+ G   T DS   VR L+    +T        W PVL  +  L     KSD Y+ +G+ +R    RC    V CRGS YP   P +  L  L  ++PLC      G       ++    N F   Q+     +  +    RT +   +M+LF  A   +++  A +   ++P+ + + LA+K AA N + +LA+++
Sbjct:  499 SSKEWTVEMPPGEHIEAIA---VGSTWAAVATSKLMVRIL-TITGIQRQVFSLPGPVVAM-------------SGHLNQLVLTYHAGNPLPDEQAL------GVKVLDLAAGRQTVNDQRLTISKKSTLSWIGFSEEGTPTTADSMGVVRMLNRSFGNT--------WVPVLETKGQLKS---KSDNYWVLGMEERTQQLRC----VLCRGSSYPPTLP-RPVLVLLPLKIPLCEMATDKGEKEESYLKSCLLSNHFTYCQKQGEDIEEEAEQQARTAQIQTIMRLFALACKTDREFRAAEYCELLPDQRSVSLAIKYAAGNRKMNLAQRL 790
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:NCBI gene;Acc:101167419])

HSP 1 Score: 88.5817 bits (218), Expect = 1.417e-17
Identity = 128/452 (28.32%), Postives = 182/452 (40.27%), Query Frame = 1 
Query:  493 SSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKC-VRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMGXXXXXXXXXXQHNMAVYARSLV--ASHRESPXXXXXXXXXXXXSTVAEEEQQESTGQSNQQPPSTNQIPNPEFANIWEEFFGEKPQPVA---KAVAKEDIKHPFK 1776
            SSW    EW V +P  N E V   CL GQ +A V T    VR F  + GG+Q  V S+ G  + +A     L+           VV     G             D+ +        +         PLPLS    L W+GF+  G    VDS+  VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+GSRYP   P +  LA L F+LPLC      G       Q E QF  +    N     S S    +E            LLMK+F  +  L ++    ++  +M    V+ LA++ A+R+ R  LA+++ E+A E+ ++ Q          +  +  R S   G     G   ++  +EE+ E  GQ  +  PS  +    +       F  E   PV     AV K    +PFK
Sbjct:  669 SSWDTNKEWMVDMP--NGEDVKALCL-GQGWAAVATSALMVRLF--SIGGVQREVFSLPGPVVCMAGHGEQLL-----------VVYHRATGFD----------GDQALGVQLLQLSRRRRRVLSGEPLPLSHKSYLSWLGFTGEGTPCFVDSEGVVRMLNRALANT--------WTPVCNTRDTCKS---KSDHYWVVGVHENPQQLRC----IPCKGSRYPPTLP-RPALAILPFKLPLCQTTTEKG-------QMEEQFWRSALFHNHYCFLSTSGFEVDEDAQTRSEKEKQELLMKMFALSCRLEREFRCVELAELM-TQNVVPLAIRYASRSRRMALAQRLSEIAMEKTIQSQEEEPEEEDEDLRYSGIRRSSEFGEAELAGGRRASRLQEEEAEFRGQ--RSAPSEEEEEETQTGTNVNPFAKETGSPVTPSVTAVGKAGRANPFK 1068
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:NCBI gene;Acc:101167419])

HSP 1 Score: 88.1965 bits (217), Expect = 1.470e-17
Identity = 128/452 (28.32%), Postives = 182/452 (40.27%), Query Frame = 1 
Query:  493 SSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKC-VRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMGXXXXXXXXXXQHNMAVYARSLV--ASHRESPXXXXXXXXXXXXSTVAEEEQQESTGQSNQQPPSTNQIPNPEFANIWEEFFGEKPQPVA---KAVAKEDIKHPFK 1776
            SSW    EW V +P  N E V   CL GQ +A V T    VR F  + GG+Q  V S+ G  + +A     L+           VV     G             D+ +        +         PLPLS    L W+GF+  G    VDS+  VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+GSRYP   P +  LA L F+LPLC      G       Q E QF  +    N     S S    +E            LLMK+F  +  L ++    ++  +M    V+ LA++ A+R+ R  LA+++ E+A E+ ++ Q          +  +  R S   G     G   ++  +EE+ E  GQ  +  PS  +    +       F  E   PV     AV K    +PFK
Sbjct:  513 SSWDTNKEWMVDMP--NGEDVKALCL-GQGWAAVATSALMVRLF--SIGGVQREVFSLPGPVVCMAGHGEQLL-----------VVYHRATGFD----------GDQALGVQLLQLSRRRRRVLSGEPLPLSHKSYLSWLGFTGEGTPCFVDSEGVVRMLNRALANT--------WTPVCNTRDTCKS---KSDHYWVVGVHENPQQLRC----IPCKGSRYPPTLP-RPALAILPFKLPLCQTTTEKG-------QMEEQFWRSALFHNHYCFLSTSGFEVDEDAQTRSEKEKQELLMKMFALSCRLEREFRCVELAELM-TQNVVPLAIRYASRSRRMALAQRLSEIAMEKTIQSQEEEPEEEDEDLRYSGIRRSSEFGEAELAGGRRASRLQEEEAEFRGQ--RSAPSEEEEEETQTGTNVNPFAKETGSPVTPSVTAVGKAGRANPFK 912
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Match: wdhd1 (WD repeat and HMG-box DNA binding protein 1 [Source:NCBI gene;Acc:101167419])

HSP 1 Score: 87.8113 bits (216), Expect = 2.314e-17
Identity = 103/346 (29.77%), Postives = 143/346 (41.33%), Query Frame = 1 
Query:  493 SSWS---EWNVLLPRANREKVVGCCLVGQMYAIVMTQKC-VRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSA---LKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRAN--RCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNES----------NLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKM 1473
            SSW    EW V +P  N E V   CL GQ +A V T    VR F  + GG+Q  V S+ G  + +A     L+           VV     G             D+ +        +         PLPLS    L W+GF+  G    VDS+  VR L+  L +T        WTPV N R        KSD Y+ +GV +     RC    + C+GSRYP   P +  LA L F+LPLC      G       Q E QF  +    N     S S    +E            LLMK+F  +  L ++    ++  +M    V+ LA++ A+R+ R  LA+++
Sbjct:  509 SSWDTNKEWMVDMP--NGEDVKALCL-GQGWAAVATSALMVRLF--SIGGVQREVFSLPGPVVCMAGHGEQLL-----------VVYHRATGFD----------GDQALGVQLLQLSRRRRRVLSGEPLPLSHKSYLSWLGFTGEGTPCFVDSEGVVRMLNRALANT--------WTPVCNTRDTCKS---KSDHYWVVGVHENPQQLRC----IPCKGSRYPPTLP-RPALAILPFKLPLCQTTTEKG-------QMEEQFWRSALFHNHYCFLSTSGFEVDEDAQTRSEKEKQELLMKMFALSCRLEREFRCVELAELM-TQNVVPLAIRYASRSRRMALAQRL 804
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000032761.1 (SMESG000032761.1)

HSP 1 Score: 1156.74 bits (2991), Expect = 0.000e+0
Identity = 642/648 (99.07%), Postives = 643/648 (99.23%), Query Frame = 1 
Query:   31 MDSXXXXXXXXXXXXTIFDYDKNLKYTVDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXXXXVHVRPLGKSSWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMGXXXXXXXXXXQHNMAVYARSLVASHRESPXXXXXXXXXXXXSTVAEEEQQESTGQSNQQPPSTNQIPNPEFANIWEEFFGEKPQPVAKAVAKEDIKHPFKTFIPKPVSRLGLKVIDEMVRXXXXXXXXXXXXXXFGKFVPLPSPPNKKRKSQFQNGSTLDKYFKKQ 1974
            MDSNNLNKKLHKKAKTIFDYDKNLKYTVDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCANNEDNDSSEDEEEPLEPALVHVRPLGKSSWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLC    GGGP SGILRQTENQFLVNQQLSNWNDSTSISLLRTNES+LLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMGELAHEEELEEQHNMAVYARSLVASHRESPAIGTIGAGGDGISTVAEEEQQESTGQSNQQPPSTNQIPNPEFANIWEEFFGEKPQPVAKAVAKEDIKHPFKTFIPKPVSRLGLKVIDEMVRVVPPVKSPKKIPNPFGKFVPLPSPPNKKRKSQFQNGSTLDKYFKKQ
Sbjct:    1 MDSNNLNKKLHKKAKTIFDYDKNLKYTVDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCANNEDNDSSEDEEEPLEPALVHVRPLGKSSWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPLSALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLC----GGGPSSGILRQTENQFLVNQQLSNWNDSTSISLLRTNESDLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMGELAHEEELEEQHNMAVYARSLVASHRESPAIGTIGAGGDGISTVAEEEQQESTGQSNQQPPSTNQIPNPEFANIWEEFFGEKPQPVAKAVAKEDIKHPFKTFIPKPVSRLGLKVIDEMVRVVPPVKSPKKIPNPFGKFVPLPSPPNKKRKSQFQNGSTLDKYFKKQ 644
[Close]
BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Match: SMESG000076132.1 (SMESG000076132.1)

HSP 1 Score: 483.411 bits (1243), Expect = 8.017e-159
Identity = 261/466 (56.01%), Postives = 330/466 (70.82%), Query Frame = 1 
Query:  103 KYTVDKKRPHLPIRSTWCPRTGNRQILLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDVNRHALLMISRQFGEADPNWWATDKSCXXXXXXXXXXXXXXXXXX-----XXVHVRPLGKSSWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGGIQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMDIYKATDKPVKWTDKGKWKAVVATTEWHPLPL---SALKWIGFSDSGELYTVDSKQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLDRANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCXXXXXXXXXXXILRQTENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAFDIGTMMPNSQVMKLAVKCAARNNREDLAEKMG 1476
            K  +   R HLPIRST CPR GN+QIL+WNPIA L+NHFD++N  + FL VDFQD AV++ LIY H V RYELGDVNR+AL++IS Q      N       C  ++ +D   + EE  +      ALVHVRPL  SSW+EWN  LP  NRE V+GCCLVGQ YAIVM+ K +RYF+AN GGIQAY+ES+HG+P+AIASSSSYL+S +   +N  RVV V++    L WR+D++K++DKPVKW +KG+++AVVATT WH L L   S LKWIGFS+SG L+ +DSKQ ++RLH++   T K  S+PRW P LNLR+AL K+ R  DRYFPIGV+DR +RC  LAV CR SRYP  +PWQ  L+T++FQLPLCG           L + EN  LVNQ LSNW DS +IS +   E  LL+KLF NA+   QD  AF IG +MP+SQV++LA++ AARNN++ LAEKMG
Sbjct:  404 KAALKTNRTHLPIRSTQCPRNGNKQILMWNPIAALKNHFDDENDYNCFLEVDFQDKAVSNNLIYRHSVMRYELGDVNRNALMLISMQTDNRSRN--GDGGHCQVSDSSDDEREREEEEDKEDDQPALVHVRPLNGSSWTEWNTKLP--NRETVIGCCLVGQNYAIVMSDKYLRYFIANGGGIQAYIESLHGSPVAIASSSSYLLSQS-TGENFTRVVTVTDDNGYLWWRIDMFKSSDKPVKWFNKGRYQAVVATTSWHILSLPKSSTLKWIGFSESGALFIMDSKQSIQRLHLEYNETSKEFSKPRWMPALNLRSALPKDCRFIDRYFPIGVMDRGDRCGVLAVHCRDSRYPTVTPWQT-LSTVDFQLPLCGVQKSE------LIENENGMLVNQLLSNWTDSANISSVEFTEKQLLLKLFANAVAEGQDSRAFAIGELMPDSQVIQLAIRYAARNNKQHLAEKMG 857
The following BLAST results are available for this feature:
BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 2
Match NameE-valueIdentityDescription
WDHD11.900e-1425.74WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
WDHD12.278e-1425.74WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 2
Match NameE-valueIdentityDescription
ctf-42.774e-1122.35Chromosome Transmission Fidelity factor homolog [... [more]
ctf-42.774e-1122.35Chromosome Transmission Fidelity factor homolog [... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 2
Match NameE-valueIdentityDescription
wdhd16.986e-1628.61WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
wdhd17.304e-1628.61WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
tab32.544e-1826.45TGF-beta activated kinase 1 (MAP3K7) binding prote... [more]
tab33.000e-1826.08TGF-beta activated kinase 1 (MAP3K7) binding prote... [more]
tab33.160e-1826.08TGF-beta activated kinase 1 (MAP3K7) binding prote... [more]
tab33.579e-1826.08TGF-beta activated kinase 1 (MAP3K7) binding prote... [more]
tab33.816e-1826.08TGF-beta activated kinase 1 (MAP3K7) binding prote... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Wdhd11.458e-1331.51WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
Wdhd11.623e-1331.51WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 3
Match NameE-valueIdentityDescription
sp|O13046|WDHD1_XENLA2.232e-1528.70WD repeat and HMG-box DNA-binding protein 1 OS=Xen... [more]
sp|O75717|WDHD1_HUMAN9.122e-1425.74WD repeat and HMG-box DNA-binding protein 1 OS=Hom... [more]
sp|P59328|WDHD1_MOUSE1.154e-1231.51WD repeat and HMG-box DNA-binding protein 1 OS=Mus... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A158QFG51.310e-1724.47WD_REPEATS_REGION domain-containing protein OS=Hym... [more]
A0A564XWR81.368e-1724.47WD_REPEATS_REGION domain-containing protein (Fragm... [more]
A0A183IZ731.577e-1723.75Mcl1_mid domain-containing protein OS=Soboliphyme ... [more]
A0A2C9LR715.825e-1727.71HMG box domain-containing protein OS=Biomphalaria ... [more]
A0A2I4C2623.101e-1627.07WD repeat and HMG-box DNA-binding protein 1 OS=Aus... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 1
Match NameE-valueIdentityDescription
wdhd14.480e-1428.78WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO447864.296e-1526.59Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
wdhd11.417e-1728.32WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
wdhd11.470e-1728.32WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
wdhd12.314e-1729.77WD repeat and HMG-box DNA binding protein 1 [Sourc... [more]
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BLAST of WD_REPEATS_REGION domain-containing protein vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 2
Match NameE-valueIdentityDescription
SMESG000032761.10.000e+099.07SMESG000032761.1[more]
SMESG000076132.18.017e-15956.01SMESG000076132.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018395 ID=SMED30018395|Name=WD_REPEATS_REGION domain-containing protein|organism=Schmidtea mediterranea sexual|type=transcript|length=2191bp
TAGTAATTAAAAAAAGAAATTTAATTTAATATGGATTCTAATAATTTAAA
TAAAAAATTACATAAAAAAGCGAAAACTATATTTGATTACGATAAAAATT
TAAAGTATACTGTAGATAAGAAACGCCCACATCTGCCAATAAGATCAACC
TGGTGTCCAAGAACGGGAAACAGACAGATATTGTTGTGGAATCCGATTGC
AATACTCAGAAATCATTTTGACAACGATAACGGTTGCGACGACTTTCTGG
TGGTCGATTTCCAGGATGCAGCGGTGAATAGCAAACTTATTTATTGGCAT
AGAGTTAGGAGGTATGAATTGGGCGATGTGAATCGGCACGCGTTGCTGAT
GATTTCTAGACAATTTGGTGAAGCCGATCCTAATTGGTGGGCGACGGACA
AATCTTGTGCTAATAATGAAGACAACGATAGCAGTGAGGATGAAGAAGAG
CCTTTAGAACCAGCTCTCGTGCATGTGCGACCACTAGGTAAGAGCTCATG
GAGCGAGTGGAATGTCCTGTTACCACGTGCCAATCGGGAGAAGGTTGTTG
GGTGCTGCCTTGTTGGGCAGATGTACGCTATCGTGATGACACAGAAATGC
GTACGTTATTTCATGGCCAATGCCGGCGGCATTCAGGCCTATGTAGAATC
AATCCATGGCAACCCGATAGCGATCGCATCCTCCTCGAGCTACTTGATGA
GCCCTGCCGGCCCGAGTGATAATCTCATCCGGGTTGTCATAGTGAGCGAA
GTTGGCCACCGGCTCATGTGGCGCATGGACATATACAAGGCGACAGACAA
GCCAGTCAAATGGACAGACAAAGGCAAATGGAAAGCAGTCGTTGCCACAA
CTGAATGGCATCCGTTGCCGCTGTCGGCATTGAAATGGATTGGATTCAGC
GATTCCGGGGAGCTCTACACAGTCGACAGCAAGCAGTGCGTCCGCCGGCT
CCACATAGACCTTTATCACACGGGGAAAATCGCCTCACAGCCGCGGTGGA
CGCCAGTGCTCAATCTGAGGACGGCTTTACTCAAGGAGCTTCGTAAGTCC
GACAGATATTTCCCCATCGGGGTTTTGGACCGGGCCAACAGGTGCTGCTT
CCTTGCAGTGCAGTGCCGGGGTAGCCGATATCCCGCTGCCTCCCCCTGGC
AGCAAGGCTTAGCAACGCTTGAGTTCCAGCTGCCGCTCTGTGGCGGCGGC
GGCGGCGGCGGCCCGGGCAGCGGGATACTCAGGCAGACCGAGAATCAGTT
CCTAGTCAATCAGCAGCTGTCCAATTGGAATGACTCCACCAGCATCAGCT
TGCTCAGGACCAATGAGAGCAATTTGCTGATGAAATTGTTCCAGAATGCG
ATCGGGCTCAATCAAGACAGATTGGCCTTTGATATCGGCACAATGATGCC
TAACTCGCAAGTGATGAAATTGGCGGTGAAATGCGCCGCTAGAAATAACA
GGGAGGATCTCGCAGAGAAAATGGGTGAATTGGCACATGAGGAGGAACTG
GAGGAGCAGCACAATATGGCTGTCTATGCCAGGTCACTTGTAGCGTCACA
CAGGGAGTCACCGGCAATCGGCACAATCGGTGCTGGTGGTGATGGTATAT
CGACGGTAGCGGAGGAGGAACAGCAGGAGAGCACTGGGCAATCAAATCAG
CAGCCCCCATCTACCAATCAAATTCCTAATCCTGAATTTGCAAACATTTG
GGAGGAGTTTTTCGGTGAGAAACCGCAGCCGGTTGCTAAGGCAGTTGCTA
AGGAGGATATAAAACACCCATTCAAGACATTTATTCCCAAGCCAGTCTCG
CGGCTCGGTTTGAAGGTCATCGATGAAATGGTTAGAGTGGTCCCCCCTGT
CAAGAGCCCAAAGAAGATTCCAAATCCTTTTGGAAAGTTTGTCCCCCTTC
CGAGCCCGCCGAACAAGAAGAGGAAATCACAGTTCCAGAATGGAAGCACT
TTAGATAAATATTTCAAGAAGCAATAGATATTTTATTTCTGTTTTCATTG
ATTGATGTCGTATGAGATTATGTAACCGCATGCTTGTGTGTCAGTGAGTA
CGTGTTTGTGTGTGTGTCAGTACGTGTTTGTGTGTGGTCAGTACGTGTTT
GTGAGTGTCAATTATGCTTGTGTGTGAGTCAGTACATGTTTGTGATTGAG
TCAGTACGTGTCTGAGTGTGTCAATTATGCTTGTGTGTGTC
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protein sequence of SMED30018395-orf-1

>SMED30018395-orf-1 ID=SMED30018395-orf-1|Name=SMED30018395-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=649bp
MDSNNLNKKLHKKAKTIFDYDKNLKYTVDKKRPHLPIRSTWCPRTGNRQI
LLWNPIAILRNHFDNDNGCDDFLVVDFQDAAVNSKLIYWHRVRRYELGDV
NRHALLMISRQFGEADPNWWATDKSCANNEDNDSSEDEEEPLEPALVHVR
PLGKSSWSEWNVLLPRANREKVVGCCLVGQMYAIVMTQKCVRYFMANAGG
IQAYVESIHGNPIAIASSSSYLMSPAGPSDNLIRVVIVSEVGHRLMWRMD
IYKATDKPVKWTDKGKWKAVVATTEWHPLPLSALKWIGFSDSGELYTVDS
KQCVRRLHIDLYHTGKIASQPRWTPVLNLRTALLKELRKSDRYFPIGVLD
RANRCCFLAVQCRGSRYPAASPWQQGLATLEFQLPLCGGGGGGGPGSGIL
RQTENQFLVNQQLSNWNDSTSISLLRTNESNLLMKLFQNAIGLNQDRLAF
DIGTMMPNSQVMKLAVKCAARNNREDLAEKMGELAHEEELEEQHNMAVYA
RSLVASHRESPAIGTIGAGGDGISTVAEEEQQESTGQSNQQPPSTNQIPN
PEFANIWEEFFGEKPQPVAKAVAKEDIKHPFKTFIPKPVSRLGLKVIDEM
VRVVPPVKSPKKIPNPFGKFVPLPSPPNKKRKSQFQNGSTLDKYFKKQ*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000014zeta neoblast
PLANA:0000420parapharyngeal region
PLANA:0000429neoblast
PLANA:0002109X1 cell
PLANA:0002111X2 cell
Vocabulary: INTERPRO
TermDefinition
IPR022100Mcl1_mid
Vocabulary: molecular function
TermDefinition
GO:0003677DNA binding
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR022100Minichromosome loss protein Mcl1, middle regionPFAMPF12341Mcl1_midcoord: 44..386
e-value: 1.4E-33
score: 116.6
NoneNo IPR availableMOBIDB_LITEmobidb-litedisorder_predictioncoord: 610..644
NoneNo IPR availablePANTHERPTHR19932WD REPEAT AND HMG-BOX DNA BINDING PROTEINcoord: 31..543
NoneNo IPR availablePANTHERPTHR19932:SF10WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1coord: 31..543