Cathepsin L2

Overview
NameCathepsin L2
Smed IDSMED30018252
Length (bp)1107
Neoblast Clusters

Zeng et. al., 2018




▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 



 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)




Explore this single cell expression dataset with our NB Cluster Shiny App




 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Cathepsin L2 (SMED30018252) t-SNE clustered cells

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30018252) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Cathepsin L2 (SMED30018252) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Cathepsin L2 (SMED30018252) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017




Hover the mouse over a column in the graph to view average RPKM values per sample.
Sort Descending | Sort Ascending | Only Non-Zero Values | Tile/Chart | Reset

Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020




SMED30018252

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 18

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30018252SMESG000068156.1 SMESG000064685.1 SMESG000010609.1 SMESG000076470.1 SMESG000073857.1 SMESG000062429.1 SMESG000060487.1 SMESG000058575.1 SMESG000053533.1 SMESG000026676.1 SMESG000020635.1 SMESG000015751.1 SMESG000005260.1 Contig240GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
intestinal phagocyteSMED30018252SMESG000049723.1 Contig240GPL15192PMID:23079596
Forsthoefel et al., 2012
FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
pharynxSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
epidermisSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
muscle cellSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018252SMESG000049723.1 Contig40941uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018252SMESG000049723.1 Contig40941newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018252 Contig26378uc_Smed_v2PMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018252 Contig26378newmark_estsPMID:29674431
Fincher et al., 2018
FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
tail regionSMED30018252SMESG000049723.1 dd_Smed_v6_48_0_1dd_Smed_v6PMID:28171748
Stückemann et al., 2017
whole organism asexual adult RNA-sequencing evidence
gutSMED30018252SMESG000049723.1 SMED30018252smed_20140614PMID:26457503
Tu et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
parenchymaSMED30018252SMESG000049723.1 SMED30018252smed_20140614PMID:26457503
Tu et al., 2015
whole organism asexual adult colorimetric in situ hybridization evidence
intestinal phagocyteSMED30018252SMESG000049723.1 dd_Smed_v6_48_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30018252SMESG000049723.1 dd_Smed_v6_48_0dd_Smed_v6PMID:29674432
Plass et al., 2018
FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30018252SMESG000049723.1 dd_Smed_v4_48_0_1dd_Smed_v4PMID:30962434
Cote et al., 2019
whole organism asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 334.339 bits (856), Expect = 4.046e-113
Identity = 169/317 (53.31%), Postives = 211/317 (66.56%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             T +  L  +W  +K    + Y    E  RR +WE+N+K I+ HN E+  GKH++T+ +N F DMT+EEFR    G   ++      F  P    A P SVDWR KG+VTPVKNQ QCGSCW+FS TG+LEGQ +RKT  LIS SEQ LVDCSG  GN GC+GGLMD AFQY+Q   G+++E +YPY A + +C Y+    V + TGF DIP   E+AL  AVATVGPISVAIDA + SF  YK GIY EP CSS  +DHGVL +GYG E    +   +WLVKNSWG  WG+ GY+KM+KD+ N CGI++ ASYP V
Sbjct:   19 LTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSL (cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537])

HSP 1 Score: 334.339 bits (856), Expect = 4.046e-113
Identity = 169/317 (53.31%), Postives = 211/317 (66.56%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             T +  L  +W  +K    + Y    E  RR +WE+N+K I+ HN E+  GKH++T+ +N F DMT+EEFR    G   ++      F  P    A P SVDWR KG+VTPVKNQ QCGSCW+FS TG+LEGQ +RKT  LIS SEQ LVDCSG  GN GC+GGLMD AFQY+Q   G+++E +YPY A + +C Y+    V + TGF DIP   E+AL  AVATVGPISVAIDA + SF  YK GIY EP CSS  +DHGVL +GYG E    +   +WLVKNSWG  WG+ GY+KM+KD+ N CGI++ ASYP V
Sbjct:   19 LTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 329.331 bits (843), Expect = 3.517e-111
Identity = 165/315 (52.38%), Postives = 209/315 (66.35%), Query Frame = 3
Query:  123 INSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             +  L+ +W  +K    + Y +  E  RR +WE+N+K I+ HN E+  GKH +T+ +N F DMTNEEFR        ++      F  P  +  LP SVDWR KG+VTPVKNQ+QCGSCW+FS TG+LEGQ +RKT  L+S SEQ LVDCS   GN GC+GG M  AFQY+++  G+++E +YPY A D  C Y     V + TGF+ +  G E+AL  AVATVGPISVA+DA + SFQ YKSGIY EP CSS  LDHGVL +GYG E    N   +WLVKNSWG  WG  GY+K++KD+ N CGI+T ASYP V
Sbjct:   21 FDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSV (cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538])

HSP 1 Score: 329.331 bits (843), Expect = 3.517e-111
Identity = 165/315 (52.38%), Postives = 209/315 (66.35%), Query Frame = 3
Query:  123 INSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             +  L+ +W  +K    + Y +  E  RR +WE+N+K I+ HN E+  GKH +T+ +N F DMTNEEFR        ++      F  P  +  LP SVDWR KG+VTPVKNQ+QCGSCW+FS TG+LEGQ +RKT  L+S SEQ LVDCS   GN GC+GG M  AFQY+++  G+++E +YPY A D  C Y     V + TGF+ +  G E+AL  AVATVGPISVA+DA + SFQ YKSGIY EP CSS  LDHGVL +GYG E    N   +WLVKNSWG  WG  GY+K++KD+ N CGI+T ASYP V
Sbjct:   21 FDQNLDTKWYQWKATHRRLYGANEEGWRRAVWEKNMKMIELHNGEYSQGKHGFTMAMNAFGDMTNEEFRQMMGCFRNQKFRKGKVFREPLFLD-LPKSVDWRKKGYVTPVKNQKQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSRPQGNQGCNGGFMARAFQYVKENGGLDSEESYPYVAVDEICKYRPENSVANDTGFTVVAPGKEKALMKAVATVGPISVAMDAGHSSFQFYKSGIYFEPDCSSKNLDHGVLVVGYGFEGANSNNSKYWLVKNSWGPEWGSNGYVKIAKDKNNHCGIATAASYPNV 334          
BLAST of Cathepsin L2 vs. Ensembl Human
Match: CTSK (cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536])

HSP 1 Score: 321.242 bits (822), Expect = 4.527e-108
Identity = 159/310 (51.29%), Postives = 209/310 (67.42%), Query Frame = 3
Query:  135 LNDEWEAYKTQFGKKYVS-LNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV----SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYP 1046
            L+  WE +K    K+Y + ++EISRRLIWE+NLKYI  HNLE  LG HTY L +NH  DMT+EE      G+    S  R N T +   PE  G  P SVD+R KG+VTPVKNQ QCGSCW+FS+ G+LEGQ  +KT  L++ S Q LVDC     N+GC GG M +AFQY+Q+  GI++E  YPY  Q+ +C+Y+ +     C G+ +IP GNE+AL  AVA VGP+SVAIDAS  SFQ Y  G+Y +  C+S  L+H VLA+GYG + G   W++KNSWG  WG +GYI M++++ N CGI+ +AS+P
Sbjct:   22 LDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYI--PEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 317.39 bits (812), Expect = 6.421e-107
Identity = 154/312 (49.36%), Postives = 213/312 (68.27%), Query Frame = 3
Query:  141 DEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRA-----NYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT--ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            ++W+ YK  F K+Y    E +    + +N+ +I+ HN +H LG+ T+ +GLNH AD+   ++R         G S  R+  +S F+AP NV  +P  VDWR    VT VKNQ  CGSCW+FS TG+LEGQH RK   L+S SEQ LVDCS  +GN+GC+GGLMD AF+YI+  +G++ E +YPY  +D  C ++K  V     G+ D P G+E+ L  AVAT GPIS+AIDA + SFQLYK G+Y + +CSS +LDHGVL +GYGT  E+G ++W+VKNSWG GWG +GYI++++++ N CG++T ASYPLV
Sbjct:   30 EKWDDYKEDFDKEYSESEEQTYMEAFVKNMIHIENHNRDHRLGRKTFEMGLNHIADLPFSQYRKLNGYRRLFGDS--RIKNSSSFLAPFNV-QVPDEVDWRDTHLVTDVKNQGMCGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHG-DYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 242.662 bits (618), Expect = 1.422e-79
Identity = 112/198 (56.57%), Postives = 150/198 (75.76%), Query Frame = 3
Query:  468 CGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT--ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            CGSCW+FS TG+LEGQH RK   L+S SEQ LVDCS  +GN+GC+GGLMD AF+YI+  +G++ E +YPY  +D  C ++K  V     G+ D P G+E+ L  AVAT GPIS+AIDA + SFQLYK G+Y + +CSS +LDHGVL +GYGT  E+G ++W+VKNSWG GWG +GYI++++++ N CG++T ASYPLV
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHG-DYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: cpl-1 (CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H9G333])

HSP 1 Score: 242.662 bits (618), Expect = 1.422e-79
Identity = 112/198 (56.57%), Postives = 150/198 (75.76%), Query Frame = 3
Query:  468 CGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT--ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            CGSCW+FS TG+LEGQH RK   L+S SEQ LVDCS  +GN+GC+GGLMD AF+YI+  +G++ E +YPY  +D  C ++K  V     G+ D P G+E+ L  AVAT GPIS+AIDA + SFQLYK G+Y + +CSS +LDHGVL +GYGT  E+G ++W+VKNSWG GWG +GYI++++++ N CG++T ASYPLV
Sbjct:    2 CGSCWAFSATGALEGQHARKLGQLVSLSEQNLVDCSTKYGNHGCNGGLMDQAFEYIRDNHGVDTEESYPYKGRDMKCHFNKKTVGADDKGYVDTPEGDEEQLKIAVATQGPISIAIDAGHRSFQLYKKGVYYDEECSSEELDHGVLLVGYGTDPEHG-DYWIVKNSWGAGWGEKGYIRIARNRNNHCGVATKASYPLV 198          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597500:1 gene:WBGene00007055.1 transcript:F41E6.6.2 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 191.815 bits (486), Expect = 1.579e-56
Identity = 115/304 (37.83%), Postives = 172/304 (56.58%), Query Frame = 3
Query:  174 KKYVSLNEISRRL-IWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLG------VSP-KRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAF-QYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQ--CSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            KKY +  E+ +R  ++++N K I++   +++ G   Y  G   F+DMT  EF+   L       V P ++ NF  H +   N   LP S DWR KG VT VKNQ  CGSCW+FSTTG++EG  +     L+S SEQ+LVDC     + GC+GGL  +A+ + I+  G+E E  YPY  +   C   +  +     G  ++PH +E  +   + T GPIS+ ++A+  + Q Y+ G+ +  +  C    L+HGVL +GYG +  K +W+VKNSWG  WG  GY K+ + + N CG+  MA+  LV
Sbjct:  183 KKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTI-NEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSM--DQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPH-DEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Celegans
Match: tag-196 (pep chromosome:WBcel235:V:8594914:8597469:1 gene:WBGene00007055.1 transcript:F41E6.6.1 gene_biotype:protein_coding transcript_biotype:protein_coding gene_symbol:tag-196)

HSP 1 Score: 191.815 bits (486), Expect = 1.579e-56
Identity = 115/304 (37.83%), Postives = 172/304 (56.58%), Query Frame = 3
Query:  174 KKYVSLNEISRRL-IWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLG------VSP-KRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAF-QYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQ--CSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            KKY +  E+ +R  ++++N K I++   +++ G   Y  G   F+DMT  EF+   L       V P ++ NF  H +   N   LP S DWR KG VT VKNQ  CGSCW+FSTTG++EG  +     L+S SEQ+LVDC     + GC+GGL  +A+ + I+  G+E E  YPY  +   C   +  +     G  ++PH +E  +   + T GPIS+ ++A+  + Q Y+ G+ +  +  C    L+HGVL +GYG +  K +W+VKNSWG  WG  GY K+ + + N CG+  MA+  LV
Sbjct:  183 KKYTNKREVLKRFRVFKKNAKVIRELQ-KNEQGTAVY--GFTKFSDMTTMEFKKIMLPYQWEQPVYPMEQANFEKHDVTI-NEEDLPESFDWREKGAVTQVKNQGNCGSCWAFSTTGNVEGAWFIAKNKLVSLSEQELVDCDSM--DQGCNGGLPSNAYKEIIRMGGLEPEDAYPYDGRGETCHLVRKDIAVYINGSVELPH-DEVEMQKWLVTKGPISIGLNAN--TLQFYRHGVVHPFKIFCEPFMLNHGVLIVGYGKDGRKPYWIVKNSWGPNWGEAGYFKLYRGK-NVCGVQEMATSALV 476          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087592)

HSP 1 Score: 327.405 bits (838), Expect = 1.019e-110
Identity = 164/321 (51.09%), Postives = 219/321 (68.22%), Query Frame = 3
Query:  141 DEWEAYKTQFGKKYVSLNEISRRL-IWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH--------------FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +EW  +K +  K Y    E   RL I+ +N   I +HN     GK ++ L +N +AD+ + EFR    G      N+T H              FI+P +V  LP SVDWRTKG VT VK+Q  CGSCW+FS+TG+LEGQH+RK+  L+S SEQ LVDCS  +GNNGC+GGLMD+AF+YI+   GI+ E +YPY A D +C ++K  V  +  GF+DIP G+E+ +A AVATVGP+SVAIDAS+ SFQ Y  G+YNEPQC +  LDHGVL +G+GT E+G+++WLVKNSWG  WG +G+IKM +++ NQCGI++ +SYPLV
Sbjct:   27 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNG-----FNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 341          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0087593)

HSP 1 Score: 328.176 bits (840), Expect = 1.481e-110
Identity = 164/321 (51.09%), Postives = 219/321 (68.22%), Query Frame = 3
Query:  141 DEWEAYKTQFGKKYVSLNEISRRL-IWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH--------------FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +EW  +K +  K Y    E   RL I+ +N   I +HN     GK ++ L +N +AD+ + EFR    G      N+T H              FI+P +V  LP SVDWRTKG VT VK+Q  CGSCW+FS+TG+LEGQH+RK+  L+S SEQ LVDCS  +GNNGC+GGLMD+AF+YI+   GI+ E +YPY A D +C ++K  V  +  GF+DIP G+E+ +A AVATVGP+SVAIDAS+ SFQ Y  G+YNEPQC +  LDHGVL +G+GT E+G+++WLVKNSWG  WG +G+IKM +++ NQCGI++ +SYPLV
Sbjct:   57 EEWHTFKLEHRKNYQDETEERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNG-----FNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 371          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0339955)

HSP 1 Score: 318.161 bits (814), Expect = 4.107e-107
Identity = 158/302 (52.32%), Postives = 210/302 (69.54%), Query Frame = 3
Query:  195 EISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH--------------FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E  R  I+ +N   I +HN     GK ++ L +N +AD+ + EFR    G      N+T H              FI+P +V  LP SVDWRTKG VT VK+Q  CGSCW+FS+TG+LEGQH+RK+  L+S SEQ LVDCS  +GNNGC+GGLMD+AF+YI+   GI+ E +YPY A D +C ++K  V  +  GF+DIP G+E+ +A AVATVGP+SVAIDAS+ SFQ Y  G+YNEPQC +  LDHGVL +G+GT E+G+++WLVKNSWG  WG +G+IKM +++ NQCGI++ +SYPLV
Sbjct:   43 ERFRLKIFNENKHKIAKHNQRFAEGKVSFKLAVNKYADLLHHEFRQLMNG-----FNYTLHKQLRAADESFKGVTFISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 338          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: Cp1 (gene:FBgn0013770 transcript:FBtr0304021)

HSP 1 Score: 296.975 bits (759), Expect = 5.215e-100
Identity = 138/227 (60.79%), Postives = 180/227 (79.30%), Query Frame = 3
Query:  378 FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            FI+P +V  LP SVDWRTKG VT VK+Q  CGSCW+FS+TG+LEGQH+RK+  L+S SEQ LVDCS  +GNNGC+GGLMD+AF+YI+   GI+ E +YPY A D +C ++K  V  +  GF+DIP G+E+ +A AVATVGP+SVAIDAS+ SFQ Y  G+YNEPQC +  LDHGVL +G+GT E+G+++WLVKNSWG  WG +G+IKM +++ NQCGI++ +SYPLV
Sbjct:   24 FISPAHV-TLPKSVDWRTKGAVTAVKDQGHCGSCWAFSSTGALEGQHFRKSGVLVSLSEQNLVDCSTKYGNNGCNGGLMDNAFRYIKDNGGIDTEKSYPYEAIDDSCHFNKGTVGATDRGFTDIPQGDEKKMAEAVATVGPVSVAIDASHESFQFYSEGVYNEPQCDAQNLDHGVLVVGFGTDESGEDYWLVKNSWGTTWGDKGFIKMLRNKENQCGIASASSYPLV 249          
BLAST of Cathepsin L2 vs. Ensembl Fly
Match: CG5367 (gene:FBgn0032228 transcript:FBtr0080055)

HSP 1 Score: 230.335 bits (586), Expect = 1.150e-72
Identity = 118/310 (38.06%), Postives = 194/310 (62.58%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYV-SLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGA-----LPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+E +K    +KY+ + +E+     +E+N K I++HN  +  G+ ++ L  N FADM+ + +   +L +    +  ++  +A E VG+     +P S+DWR+KGF+TP  NQ  CGSC++FS   S+ GQ +++T  ++S S+QQ+VDCS S GN GC GG + +   Y+Q   GI  +  YPY A+ G C +     V + T ++ +P  +EQA+ +AV  +GP++++I+AS  +FQLY  GIY++P CSS+ ++H ++ IG+    GK++W++KN WG  WG  GYI++ K   N CGI+  A+Y +V
Sbjct:   35 EFEKFKNNNNRKYLRTYDEMRSYKAFEENFKVIEEHNQNYKEGQTSFRLKPNIFADMSTDGYLKGFLRLLKSNIEDSADNMA-EIVGSPLMANVPESLDWRSKGFITPPYNQLSCGSCYAFSIAESIMGQVFKRTGKILSLSKQQIVDCSVSHGNQGCVGGSLRNTLSYLQSTGGIMRDQDYPYVARKGKCQFVPDLSVVNVTSWAILPVRDEQAIQAAVTHIGPVAISINASPKTFQLYSDGIYDDPLCSSASVNHAMVVIGF----GKDYWILKNWWGQNWGENGYIRIRKGV-NMCGIANYAAYAIV 338          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 375.555 bits (963), Expect = 1.344e-129
Identity = 181/310 (58.39%), Postives = 225/310 (72.58%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT-----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K +FGK Y S  E S R+L W  N K +  HN+  D G  +Y LG+ +FADM+NEE+R          MN T     S F        +P +VDWR KG+VT +K+Q+QCGSCW+FS TGSLEGQ +RKT  L+S SEQQLVDCSGS+GN GCDGGLMD AFQYI+   G++ E +YPY AQDG C ++ S V  SCTG+ DI  G+E AL  AVAT+GPISVAIDA + SFQLY SG+YNEP CSSS+LDHGVLA+GYG+ NG ++W+VKNSWG+ WG+QGYI MS+++ NQCGI+T ASYPLV
Sbjct:   25 EFHAWKLKFGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 375.555 bits (963), Expect = 1.344e-129
Identity = 181/310 (58.39%), Postives = 225/310 (72.58%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT-----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K +FGK Y S  E S R+L W  N K +  HN+  D G  +Y LG+ +FADM+NEE+R          MN T     S F        +P +VDWR KG+VT +K+Q+QCGSCW+FS TGSLEGQ +RKT  L+S SEQQLVDCSGS+GN GCDGGLMD AFQYI+   G++ E +YPY AQDG C ++ S V  SCTG+ DI  G+E AL  AVAT+GPISVAIDA + SFQLY SG+YNEP CSSS+LDHGVLA+GYG+ NG ++W+VKNSWG+ WG+QGYI MS+++ NQCGI+T ASYPLV
Sbjct:   25 EFHAWKLKFGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsl.1 (cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61])

HSP 1 Score: 375.555 bits (963), Expect = 1.344e-129
Identity = 181/310 (58.39%), Postives = 225/310 (72.58%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT-----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K +FGK Y S  E S R+L W  N K +  HN+  D G  +Y LG+ +FADM+NEE+R          MN T     S F        +P +VDWR KG+VT +K+Q+QCGSCW+FS TGSLEGQ +RKT  L+S SEQQLVDCSGS+GN GCDGGLMD AFQYI+   G++ E +YPY AQDG C ++ S V  SCTG+ DI  G+E AL  AVAT+GPISVAIDA + SFQLY SG+YNEP CSSS+LDHGVLA+GYG+ NG ++W+VKNSWG+ WG+QGYI MS+++ NQCGI+T ASYPLV
Sbjct:   25 EFHAWKLKFGKSYRSAEEESHRQLTWLTNRKLVLVHNMMADQGLKSYRLGMTYFADMSNEEYRQLVFRGCLGSMNNTKARGGSTFFRLRKAAVVPDTVDWRDKGYVTDIKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGSYGNYGCDGGLMDQAFQYIEANKGLDTEDSYPYEAQDGECRFNPSTVGASCTGYVDIASGDESALQEAVATIGPISVAIDAGHSSFQLYSSGVYNEPDCSSSELDHGVLAVGYGSSNGDDYWIVKNSWGLDWGVQGYILMSRNKSNQCGIATAASYPLV 334          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106])

HSP 1 Score: 363.229 bits (931), Expect = 1.154e-124
Identity = 176/318 (55.35%), Postives = 223/318 (70.13%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKR-MNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGN-CVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            T++ +LND W+ +K    KKY +  E  RR+IWE+NLK I+ HNLEH +G HTY LG+NHF DMT+EEFR    G   K+   F        N   +P+ +DWR KG+VTPVK+Q +CGSCW+FSTTG+LEGQ +RKT  L+S SEQ LVDCS   GN GC+GGLMD AFQY++ Q G+++E +YPY   D   C +D      + TGF DIP G E+AL  A+A VGP+SVAIDA + SFQ Y+SGIY E +CSS +LDHGVLA+GYG E    +GK +W+VKNSW   WG +GYI M+KD+ N CGI+T ASYPLV
Sbjct:   20 TLDQQLNDHWDQWKKWHSKKYHATEEGWRRIIWEKNLKKIEMHNLEHSMGIHTYRLGMNHFGDMTHEEFRQVMNGFKHKKDRRFRGSLFMEPNFIEVPNKLDWREKGYVTPVKDQGECGSCWAFSTTGALEGQMFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDQNGLDSEESYPYLGTDDQPCHFDPKNSAANDTGFVDIPSGKERALMKAIAAVGPVSVAIDAGHESFQFYQSGIYYEKECSSEELDHGVLAVGYGFEGEDVDGKKYWIVKNSWSENWGDKGYIYMAKDRHNHCGIATAASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Match: ctsla (cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106])

HSP 1 Score: 363.229 bits (931), Expect = 1.154e-124
Identity = 176/318 (55.35%), Postives = 223/318 (70.13%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKR-MNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGN-CVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            T++ +LND W+ +K    KKY +  E  RR+IWE+NLK I+ HNLEH +G HTY LG+NHF DMT+EEFR    G   K+   F        N   +P+ +DWR KG+VTPVK+Q +CGSCW+FSTTG+LEGQ +RKT  L+S SEQ LVDCS   GN GC+GGLMD AFQY++ Q G+++E +YPY   D   C +D      + TGF DIP G E+AL  A+A VGP+SVAIDA + SFQ Y+SGIY E +CSS +LDHGVLA+GYG E    +GK +W+VKNSW   WG +GYI M+KD+ N CGI+T ASYPLV
Sbjct:   20 TLDQQLNDHWDQWKKWHSKKYHATEEGWRRIIWEKNLKKIEMHNLEHSMGIHTYRLGMNHFGDMTHEEFRQVMNGFKHKKDRRFRGSLFMEPNFIEVPNKLDWREKGYVTPVKDQGECGSCWAFSTTGALEGQMFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDQNGLDSEESYPYLGTDDQPCHFDPKNSAANDTGFVDIPSGKERALMKAIAAVGPVSVAIDAGHESFQFYQSGIYYEKECSSEELDHGVLAVGYGFEGEDVDGKKYWIVKNSWSENWGDKGYIYMAKDRHNHCGIATAASYPLV 337          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 358.607 bits (919), Expect = 1.141e-122
Identity = 177/317 (55.84%), Postives = 226/317 (71.29%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDG-NCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYG----TENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            T +  L++ W  +K    K Y    E  RR++WE+NL+ I+ HNLEH LGKH+++LG+N F DMTNEEFR    G   ++    S F+AP N  + P SVDWR KG+VTPVK+Q QCGSCW+FSTTG+LEGQHYR T  +IS SEQ LVDCS + GN GC+GGLMD AFQY++   GI++E +YPYTA+D   C YD +    + TGF D+  G+E+ L +AVA+VGP+SVA+DA + SFQ YKSGIY EP+CSS  LDHGVL +GYG     E+GK +W+VKNSW   WG  GYI ++KD+ N CGI+T ASYPLV
Sbjct:   20 TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: fcrl2 (Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-5904272])

HSP 1 Score: 358.221 bits (918), Expect = 1.721e-122
Identity = 177/317 (55.84%), Postives = 226/317 (71.29%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDG-NCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYG----TENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            T +  L++ W  +K    K Y    E  RR++WE+NL+ I+ HNLEH LGKH+++LG+N F DMTNEEFR    G   ++    S F+AP N  + P SVDWR KG+VTPVK+Q QCGSCW+FSTTG+LEGQHYR T  +IS SEQ LVDCS + GN GC+GGLMD AFQY++   GI++E +YPYTA+D   C YD +    + TGF D+  G+E+ L +AVA+VGP+SVA+DA + SFQ YKSGIY EP+CSS  LDHGVL +GYG     E+GK +W+VKNSW   WG  GYI ++KD+ N CGI+T ASYPLV
Sbjct:   27 TTDPALDNHWNLWKNWHKKSYAPKEEGWRRVLWEKNLRMIEFHNLEHSLGKHSHSLGMNQFGDMTNEEFRQLMNGYKNQKKIRGSTFLAPNNFES-PKSVDWRKKGYVTPVKDQGQCGSCWAFSTTGALEGQHYRNTGKMISLSEQNLVDCSRAQGNQGCNGGLMDQAFQYVKDNGGIDSEDSYPYTAKDDQECHYDPNYNSANDTGFVDVTSGSEKDLMNAVASVGPVSVAVDAGHQSFQFYKSGIYYEPECSSEDLDHGVLVVGYGFEGEDEDGKKYWIVKNSWSEKWGNDGYIYIAKDRHNHCGIATAASYPLV 342          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: lrfn4 (leucine rich repeat and fibronectin type III domain containing 4 [Source:Xenbase;Acc:XB-GENE-6465078])

HSP 1 Score: 317.39 bits (812), Expect = 1.854e-106
Identity = 146/288 (50.69%), Postives = 201/288 (69.79%), Query Frame = 3
Query:  195 EISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENV--GALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E +RR IWE+ LK+I  HNLE+ LG HTY +G+NH  DMT EE  A   G +  R +  +    P+ +     P+S+DWRT+G VT VKNQ  CGSC++F T G+LE Q  +K   L+SFS Q+LVDCS + GNNGC GG + ++F+Y+++YGI  ES+YPYTA++G C  DK   VG    F  +P G E  L   + TVGP+SVAID S   F++YKSG+Y +P C ++++DH VL +GYGT+NGK++WLVKNSWG+G+G +GYIKM++++GN C I++ A YP V
Sbjct:   49 ERARRTIWEETLKFITVHNLEYSLGLHTYEVGMNHLGDMTGEEVAATMTGYTGSRDSLANMTEVPKEILEAQTPASIDWRTQGCVTSVKNQGSCGSCYAFGTVGALECQWKKKMGTLVSFSPQELVDCSYTEGNNGCKGGYLQASFRYMKKYGIMEESSYPYTAKEGRCKKDKPSNVGVVKTFYVVPAGKELLLMKVLGTVGPVSVAIDCSREGFRMYKSGVYYDPYC-TTKVDHAVLVVGYGTDNGKDYWLVKNSWGVGYGDKGYIKMARNRGNNCAIASHAVYPTV 335          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: lrfn4 (leucine rich repeat and fibronectin type III domain containing 4 [Source:Xenbase;Acc:XB-GENE-6465078])

HSP 1 Score: 315.464 bits (807), Expect = 1.634e-105
Identity = 146/288 (50.69%), Postives = 201/288 (69.79%), Query Frame = 3
Query:  195 EISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENV--GALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E +RR IWE+ LK+I  HNLE+ LG HTY +G+NH  DMT EE  A   G +  R +  +    P+ +     P+S+DWRT+G VT VKNQ  CGSC++F T G+LE Q  +K   L+SFS Q+LVDCS + GNNGC GG + ++F+Y+++YGI  ES+YPYTA++G C  DK   VG    F  +P G E  L   + TVGP+SVAID S   F++YKSG+Y +P C ++++DH VL +GYGT+NGK++WLVKNSWG+G+G +GYIKM++++GN C I++ A YP V
Sbjct:   63 ERARRTIWEETLKFITVHNLEYSLGLHTYEVGMNHLGDMTGEEVAATMTGYTGSRDSLANMTEVPKEILEAQTPASIDWRTQGCVTSVKNQGSCGSCYAFGTVGALECQWKKKMGTLVSFSPQELVDCSYTEGNNGCKGGYLQASFRYMKKYGIMEESSYPYTAKEGRCKKDKPSNVGVVKTFYVVPAGKELLLMKVLGTVGPVSVAIDCSREGFRMYKSGVYYDPYC-TTKVDHAVLVVGYGTDNGKDYWLVKNSWGVGYGDKGYIKMARNRGNNCAIASHAVYPTV 349          
BLAST of Cathepsin L2 vs. Ensembl Xenopus
Match: lrfn4 (leucine rich repeat and fibronectin type III domain containing 4 [Source:Xenbase;Acc:XB-GENE-6465078])

HSP 1 Score: 309.301 bits (791), Expect = 1.605e-103
Identity = 145/288 (50.35%), Postives = 199/288 (69.10%), Query Frame = 3
Query:  195 EISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENV--GALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E +RR IWE+ LK+I  HNLE+ LG HTY +G+NH  DMT EE  A   G +  R +  +    P+ +     P+S+DWRT+G VT VKNQ  CGSC++F T G+LE Q  +K   L+SFS Q+LVDCS + GNNGC GG + ++F+Y+++YGI  ES+YPYT  +G C  DK   VG    F  +P G E  L   + TVGP+SVAID S   F++YKSG+Y +P C ++++DH VL +GYGT+NGK++WLVKNSWG+G+G +GYIKM++++GN C I++ A YP V
Sbjct:   43 ERARRTIWEETLKFITVHNLEYSLGLHTYEVGMNHLGDMTGEEVAATMTGYTGSRDSLANMTEVPKEILEAQTPASIDWRTQGCVTSVKNQGSCGSCYAFGTVGALECQWKKKMGTLVSFSPQELVDCSYTEGNNGCKGGYLQASFRYMKKYGIMEESSYPYT--EGRCKKDKPSNVGVVKTFYVVPAGKELLLMKVLGTVGPVSVAIDCSREGFRMYKSGVYYDPYC-TTKVDHAVLVVGYGTDNGKDYWLVKNSWGVGYGDKGYIKMARNRGNNCAIASHAVYPTV 327          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 330.872 bits (847), Expect = 6.328e-112
Identity = 168/308 (54.55%), Postives = 212/308 (68.83%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            EW  +K+   + Y +  E  RR IWE+N++ IQ HN E+  G+H +++ +N F DMTNEEFR    G   ++      F  P  +  +P SVDWR KG VTPVKNQ QCGSCW+FS +G LEGQ + KT  LIS SEQ LVDCS + GN GC+GGLMD AFQYI++  G+++E +YPY A+DG+C Y     V + TGF DIP   E+AL  AVATVGPISVA+DAS+ S Q Y SGIY EP CSS  LDHGVL +GYG E    N   +WLVKNSWG  WG++GYIK++KD+ N CG++T ASYP+V
Sbjct:   28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPLML-KIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsl (cathepsin L [Source:MGI Symbol;Acc:MGI:88564])

HSP 1 Score: 330.872 bits (847), Expect = 6.328e-112
Identity = 168/308 (54.55%), Postives = 212/308 (68.83%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            EW  +K+   + Y +  E  RR IWE+N++ IQ HN E+  G+H +++ +N F DMTNEEFR    G   ++      F  P  +  +P SVDWR KG VTPVKNQ QCGSCW+FS +G LEGQ + KT  LIS SEQ LVDCS + GN GC+GGLMD AFQYI++  G+++E +YPY A+DG+C Y     V + TGF DIP   E+AL  AVATVGPISVA+DAS+ S Q Y SGIY EP CSS  LDHGVL +GYG E    N   +WLVKNSWG  WG++GYIK++KD+ N CG++T ASYP+V
Sbjct:   28 EWHQWKSTHRRLYGTNEEEWRRAIWEKNMRMIQLHNGEYSNGQHGFSMEMNAFGDMTNEEFRQVVNGYRHQKHKKGRLFQEPLML-KIPKSVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHAQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEFAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKNLDHGVLLVGYGYEGTDSNKNKYWLVKNSWGSEWGMEGYIKIAKDRDNHCGLATAASYPVV 333          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsk (cathepsin K [Source:MGI Symbol;Acc:MGI:107823])

HSP 1 Score: 321.242 bits (822), Expect = 3.246e-108
Identity = 157/316 (49.68%), Postives = 208/316 (65.82%), Query Frame = 3
Query:  117 FTINSE--LNDEWEAYKTQFGKKYVS-LNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEF--RANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYP 1046
            F ++ E  L+ +WE +K    K+Y S ++EISRRLIWE+NLK I  HNLE  LG HTY L +NH  DMT+EE   +   L + P R         PE  G +P S+D+R KG+VTPVKNQ QCGSCW+FS+ G+LEGQ  +KT  L++ S Q LVDC     N GC GG M +AFQY+QQ G I++E  YPY  QD +C+Y+ +     C G+ +IP GNE+AL  AVA VGPISV+IDAS  SFQ Y  G+Y +  C    ++H VL +GYGT+ G   W++KNSWG  WG +GY  +++++ N CGI+ MAS+P
Sbjct:   14 FALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTE--NYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFP 327          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: Ctsll3 (cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917452])

HSP 1 Score: 317.39 bits (812), Expect = 9.901e-107
Identity = 156/311 (50.16%), Postives = 201/311 (64.63%), Query Frame = 3
Query:  126 NSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE-NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            N  L+  WE +KT+  K Y   +E  +R +WE N K I  HN ++  GKH ++L +N F D+TN EFR    G   ++            +G +P SVDWR  G+VTPVK+Q  CGSCW+FS  GSLEGQ +RKT  L+  S Q LVDCS S GN GCDGGL D AFQY++   G++   +YPY A +G C Y+      + TGF ++   +E AL  AVATVGPISV ID  + SFQ YK G+Y EP CSS+ LDH VL +GYG E +G+ +WLVKNSWG  WG+ GYIKM+KD+ N CGI++ ASYP+V
Sbjct:   22 NPSLDAVWEEWKTKHKKTYNMNDEGQKRAVWENNKKMIDLHNEDYLKGKHGFSLEMNAFGDLTNTEFRELMTGFQGQKTKMMMKVFQEPLLGDVPKSVDWRDHGYVTPVKDQGSCGSCWAFSAVGSLEGQMFRKTGKLVPLSVQNLVDCSWSQGNQGCDGGLPDLAFQYVKDNGGLDTSVSYPYEALNGTCRYNPKNSAATVTGFVNV-QSSEDALMKAVATVGPISVGIDTKHKSFQFYKEGMYYEPDCSSTVLDHAVLVVGYGEESDGRKYWLVKNSWGRDWGMNGYIKMAKDRNNNCGIASDASYPVV 331          
BLAST of Cathepsin L2 vs. Ensembl Mouse
Match: BC051665 (cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:2682300])

HSP 1 Score: 311.612 bits (797), Expect = 2.066e-104
Identity = 154/311 (49.52%), Postives = 203/311 (65.27%), Query Frame = 3
Query:  126 NSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE-NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +  L+  WE +KT+  K Y    E  +R +WE N+K I  HN ++  GKH + L +N F D+TN EFR    G         + F  P  +G +P SVDWR  G+VTPVK+Q  CGSCW+FS  GSLEGQ +RKT  L+  SEQ L+DCS S+GN GC+GGLM+ AFQY+++  G++   +Y Y A DG C YD      + TGF  +P  +E AL +AVA+VGP+SV ID  ++SF+ Y+ G Y EP CSS+ LDH VL +GYG E +G+ +WLVKNSWG  WG+ GYIKM+KD+ N CGI+T A YP V
Sbjct:   22 DPSLDAVWEEWKTKHRKTYNMNEEAQKRAVWENNMKMIGLHNEDYLKGKHGFNLEMNAFGDLTNTEFRELMTGFQSMGHKEMTIFQEPL-LGDVPKSVDWRDHGYVTPVKDQGHCGSCWAFSAVGSLEGQIFRKTGKLVPLSEQNLMDCSWSYGNVGCNGGLMELAFQYVKENRGLDTRESYAYEAWDGPCRYDPKYSAVNITGFVKVPL-SEDALMNAVASVGPVSVGIDTHHHSFRFYRGGTYYEPDCSSTNLDHAVLVVGYGEESDGRKYWLVKNSWGEDWGMDGYIKMAKDRDNNCGIATYAIYPTV 330          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P25782|CYSP2_HOMAM (Digestive cysteine proteinase 2 OS=Homarus americanus OX=6706 GN=LCP2 PE=2 SV=1)

HSP 1 Score: 348.977 bits (894), Expect = 2.338e-118
Identity = 167/304 (54.93%), Postives = 218/304 (71.71%), Query Frame = 3
Query:  147 WEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            WE +K ++G++YV   E S RR+I+EQN KYI++ N +++ G+ T+ L +N F DMT EEF A   G  P+R    S F   +  G   + VDWRTKG VTPVK+Q QCGSCW+FSTTGSLEGQH+ KT +LIS +EQQLVDCS  +G  GC+GG M+ AF YI+   GI+ E+ YPY A+DG+C +D + V  +C+G ++I  G+E  L  AV  +GPISV IDA++ SFQ Y SG+Y EP CS S LDH VLA+GYG+E G++FWLVKNSW   WG  GYIKMS+++ N CGI+T+ASYPLV
Sbjct:   20 WEHFKGKYGRQYVDAEEDSYRRVIFEQNQKYIEEFNKKYENGEVTFNLAMNKFGDMTLEEFNAVMKGNIPRRSAPVSVFYPKKETGPQATEVDWRTKGAVTPVKDQGQCGSCWAFSTTGSLEGQHFLKTGSLISLAEQQLVDCSRPYGPQGCNGGWMNDAFDYIKANNGIDTEAAYPYEARDGSCRFDSNSVAATCSGHTNIASGSETGLQQAVRDIGPISVTIDAAHSSFQFYSSGVYYEPSCSPSYLDHAVLAVGYGSEGGQDFWLVKNSWATSWGDAGYIKMSRNRNNNCGIATVASYPLV 323          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q24940|CATLL_FASHE (Cathepsin L-like proteinase OS=Fasciola hepatica OX=6192 GN=Cat-1 PE=1 SV=1)

HSP 1 Score: 337.035 bits (863), Expect = 1.043e-113
Identity = 155/306 (50.65%), Postives = 217/306 (70.92%), Query Frame = 3
Query:  138 NDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPE-NVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +D W  +K  + K+Y   ++  RR IWE+N+K+IQ+HNL HDLG  TYTLGLN F DMT EEF+A YL    +  +  SH +  E N  A+P  +DWR  G+VT VK+Q  CGSCW+FSTTG++EGQ+ +  +  ISFSEQQLVDCSG +GNNGC GGLM++A+QY++Q+G+E ES+YPYTA +G C Y+K   V   TG+  +  G+E  L + V    P +VA+D  +  F +Y+SGIY    CS  +++H VLA+GYGT+ G ++W+VKNSWG  WG +GYI+M++++GN CGI+++AS P+V
Sbjct:   18 DDLWHQWKRMYNKEYNGADDQHRRNIWEKNVKHIQEHNLRHDLGLVTYTLGLNQFTDMTFEEFKAKYLTEMSRASDILSHGVPYEANNRAVPDKIDWRESGYVTEVKDQGNCGSCWAFSTTGTMEGQYMKNERTSISFSEQQLVDCSGPWGNNGCSGGLMENAYQYLKQFGLETESSYPYTAVEGQCRYNKQLGVAKVTGYYTVHSGSEVELKNLVGARRPAAVAVDVES-DFMMYRSGIYQSQTCSPLRVNHAVLAVGYGTQGGTDYWIVKNSWGTYWGERGYIRMARNRGNMCGIASLASLPMV 322          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|Q9GKL8|CATL1_CHLAE (Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CTSL PE=1 SV=1)

HSP 1 Score: 334.339 bits (856), Expect = 1.512e-112
Identity = 169/317 (53.31%), Postives = 210/317 (66.25%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             T N  L  +W  +K    + Y    E  RR +WE+N+K I+ HN E+  GKH++T+ +N F DMT+EEFR    G   ++      F  P    A P SVDWR KG+VTPVKNQ QCGSCW+FS TG+LEGQ +RKT  L+S SEQ LVDCSG  GN GC+GGLMD AFQY+    G+++E +YPY A + +C Y+    V + TGF DIP   E+AL  AVATVGPISVAIDA + SF  YK GIY EP CSS  +DHGVL +GYG E    +   +WLVKNSWG  WG+ GYIKM+KD+ N CGI++ ASYP V
Sbjct:   19 LTFNHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYSQGKHSFTMAMNTFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGKLVSLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVADNGGLDSEESYPYEATEESCKYNPEYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFMFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNSKYWLVKNSWGEEWGMGGYIKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07711|CATL1_HUMAN (Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 SV=2)

HSP 1 Score: 334.339 bits (856), Expect = 1.943e-112
Identity = 169/317 (53.31%), Postives = 211/317 (66.56%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             T +  L  +W  +K    + Y    E  RR +WE+N+K I+ HN E+  GKH++T+ +N F DMT+EEFR    G   ++      F  P    A P SVDWR KG+VTPVKNQ QCGSCW+FS TG+LEGQ +RKT  LIS SEQ LVDCSG  GN GC+GGLMD AFQY+Q   G+++E +YPY A + +C Y+    V + TGF DIP   E+AL  AVATVGPISVAIDA + SF  YK GIY EP CSS  +DHGVL +GYG E    +   +WLVKNSWG  WG+ GY+KM+KD+ N CGI++ ASYP V
Sbjct:   19 LTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEA-PRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPK-QEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV 333          
BLAST of Cathepsin L2 vs. UniProt/SwissProt
Match: sp|P07154|CATL1_RAT (Cathepsin L1 OS=Rattus norvegicus OX=10116 GN=Ctsl PE=1 SV=2)

HSP 1 Score: 331.643 bits (849), Expect = 2.021e-111
Identity = 168/311 (54.02%), Postives = 211/311 (67.85%), Query Frame = 3
Query:  135 LNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             N +W  +K+   + Y +  E  RR +WE+N++ IQ HN E+  GKH +T+ +N F DMTNEEFR    G   ++      F  P  +  +P +VDWR KG VTPVKNQ QCGSCW+FS +G LEGQ + KT  LIS SEQ LVDCS   GN GC+GGLMD AFQYI++  G+++E +YPY A+DG+C Y     V + TGF DIP   E+AL  AVATVGPISVA+DAS+ S Q Y SGIY EP CSS  LDHGVL +GYG E    N   +WLVKNSWG  WG+ GYIK++KD+ N CG++T ASYP+V
Sbjct:   25 FNAQWHQWKSTHRRLYGTNEEEWRRAVWEKNMRMIQLHNGEYSNGKHGFTMEMNAFGDMTNEEFRQIVNGYRHQKHKKGRLFQEPLML-QIPKTVDWREKGCVTPVKNQGQCGSCWAFSASGCLEGQMFLKTGKLISLSEQNLVDCSHDQGNQGCNGGLMDFAFQYIKENGGLDSEESYPYEAKDGSCKYRAEYAVANDTGFVDIPQ-QEKALMKAVATVGPISVAMDASHPSLQFYSSGIYYEPNCSSKDLDHGVLVVGYGYEGTDSNKDKYWLVKNSWGKEWGMDGYIKIAKDRNNHCGLATAASYPIV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A2U8U447 (Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1)

HSP 1 Score: 505.368 bits (1300), Expect = 1.901e-177
Identity = 239/333 (71.77%), Postives = 279/333 (83.78%), Query Frame = 3
Query:   57 MQIIIXXXXXXXXXXXXPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTS-HFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            M+II+L S+FL  + A P +FTINSELNDEWE YK +F KKY +LNEISRR+IWE NLK+IQQHN+E+DLGKHTY LGLN FADMT+EEF+A YLG+ P   NFTS  FI PEN+G LP+ +DWRTKG+VTPVKNQ QCGSCW+FSTTGSLEGQH+RK+  L+SFSEQQLVDCS SF N GC+GGLMD+AF YIQ++GIE E +YPY A DG C YDK+K+VG+CTGF DI  GNE  L +AVAT GPISVAIDASN SFQ Y+ GIYNEP CSS  LDHGVLAIGYG+EN +N+W+VKNSW I WG+ GYI+MSKD+ NQCGI+TMASYPLV
Sbjct:    1 MKIILLTSIFLVTIQAVPHKFTINSELNDEWEVYKMKFSKKYETLNEISRRIIWENNLKFIQQHNVEYDLGKHTYYLGLNEFADMTHEEFKAKYLGLKPINRNFTSSRFIIPENIGDLPTRIDWRTKGYVTPVKNQGQCGSCWAFSTTGSLEGQHFRKSGKLVSFSEQQLVDCSRSFDNLGCNGGLMDNAFSYIQKFGIENEISYPYVANDGVCAYDKTKIVGTCTGFVDIKTGNETDLMAAVATQGPISVAIDASNDSFQFYRGGIYNEPHCSSKDLDHGVLAIGYGSENNENYWIVKNSWDISWGMSGYIRMSKDKMNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A267H1I6 (Uncharacterized protein OS=Macrostomum lignano OX=282301 GN=BOX15_Mlig013052g1 PE=3 SV=1)

HSP 1 Score: 416.772 bits (1070), Expect = 1.564e-142
Identity = 197/314 (62.74%), Postives = 243/314 (77.39%), Query Frame = 3
Query:  114 QFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            QFT+  ELN+EWEAYK+  GK Y +  E+ RRLIWEQNL++IQ+HNLE+D G H+YTLG+N F D+T  EF+A YL   P      S F+   NVG+LP  VDWRTKG+VT VK+Q+QCGSCW+FSTTGSLEGQH++KT NL+S SEQ LVDCSG FGN GC+GGLMD+ F+YI+   GI+ E+ YPY A+D  C +  S V  + +GF DIP  NE AL  AVAT+GPISVAIDA + SFQLYKSG+Y+E  CS +QLDHGVLA+GYGTE GK +WLVKNSWG  WG++GYI MS+++ NQCGI++ ASYPLV
Sbjct:   20 QFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQQAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A1I8GVB7 (Uncharacterized protein OS=Macrostomum lignano OX=282301 PE=3 SV=1)

HSP 1 Score: 416.772 bits (1070), Expect = 1.745e-142
Identity = 197/314 (62.74%), Postives = 243/314 (77.39%), Query Frame = 3
Query:  114 QFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            QFT+  ELN+EWEAYK+  GK Y +  E+ RRLIWEQNL++IQ+HNLE+D G H+YTLG+N F D+T  EF+A YL   P      S F+   NVG+LP  VDWRTKG+VT VK+Q+QCGSCW+FSTTGSLEGQH++KT NL+S SEQ LVDCSG FGN GC+GGLMD+ F+YI+   GI+ E+ YPY A+D  C +  S V  + +GF DIP  NE AL  AVAT+GPISVAIDA + SFQLYKSG+Y+E  CS +QLDHGVLA+GYGTE GK +WLVKNSWG  WG++GYI MS+++ NQCGI++ ASYPLV
Sbjct:   20 QFTL--ELNEEWEAYKSTHGKVYEADEELMRRLIWEQNLQHIQKHNLEYDRGVHSYTLGMNQFGDLTFTEFKAKYLSPMPAAEPEGSVFLPASNVGSLPDEVDWRTKGYVTGVKDQKQCGSCWAFSTTGSLEGQHFKKTGNLVSLSEQNLVDCSGKFGNMGCNGGLMDNGFKYIKANKGIDTEACYPYKARDEKCSFKSSCVGATVSGFVDIPAKNESALQHAVATIGPISVAIDAGHSSFQLYKSGVYSERLCSETQLDHGVLAVGYGTEGGKAYWLVKNSWGTSWGMKGYIMMSRNKKNQCGIASAASYPLV 331          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A0L8HPF9 (Uncharacterized protein OS=Octopus bimaculoides OX=37653 GN=OCBIM_22009826mg PE=3 SV=1)

HSP 1 Score: 394.43 bits (1012), Expect = 1.027e-133
Identity = 183/311 (58.84%), Postives = 237/311 (76.21%), Query Frame = 3
Query:  135 LNDEWEAYKTQFGKKY-VSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH----FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            L+  W+ Y   F KKY  + NE  RR+IWE+NL+Y+ QHNLE D+G HTY LGLN +AD+ N EF      + P+  N T++      A +N+  LP +VDWRTKG+VT VKNQ QCGSCW+FSTTGSLEGQ ++KT  L+S SEQ LVDCSGSFGNNGC+GGLMD+AF+YI+++GI++E++YPY  +D  C Y KS VV + TG+ D+   +E +L SAVA VGPISVAIDA + SFQLYK G+Y E +CS++ LDHGVLA+GYGT+NG+++WLVKNSWG  WG++GYIKM+++Q N CGI+T ASYP V
Sbjct:   26 LDQSWQTYMKLFNKKYNTAENEFVRRVIWEKNLQYVNQHNLEADMGLHTYWLGLNEYADLENREFVQRMNNLIPR--NLTTYKPKLIFANDNIKDLPDTVDWRTKGYVTEVKNQAQCGSCWAFSTTGSLEGQIFKKTGKLVSLSEQNLVDCSGSFGNNGCEGGLMDNAFKYIKKFGIDSEASYPYEGRDAKCRYKKSDVVATDTGYVDVKSMSEDSLQSAVAKVGPISVAIDAGHLSFQLYKHGVYKESRCSATALDHGVLAVGYGTDNGQDYWLVKNSWGGSWGVKGYIKMARNQNNMCGIATQASYPTV 334          
BLAST of Cathepsin L2 vs. TrEMBL
Match: A0A4Y2J2Y6 (Cathepsin L OS=Araneus ventricosus OX=182803 GN=Cp1_0 PE=3 SV=1)

HSP 1 Score: 393.275 bits (1009), Expect = 3.546e-133
Identity = 187/317 (58.99%), Postives = 236/317 (74.45%), Query Frame = 3
Query:  111 QQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVS--PKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +    + ELN+ WE +K  FGK Y    E+SRR+IWEQ +  + +HNL +DLG H+Y  G+N ++DM +EEF   + G    P + +  + ++   NV  +P  VDWRTKG VTP+KNQQQCGSCW+FSTTGSLEGQH +KT  L+S SEQ LVDCSG  GN GC+GGLMD AF+YI+   GI+ E +YPYTA+DG C + KS V  + TG+ DIP G+E+AL  AVATVGP+SVAIDAS  SFQ Y+ GIY+EPQCSS  LDHGVLA+GYGTE+G ++WLVKNSWG  WGI+GYIKMS+++ NQCGI+T ASYPLV
Sbjct:   16 RHIQFDPELNEHWENFKKVFGKVYDGTEEVSRRMIWEQRVSDVVRHNLRYDLGFHSYRKGINEYSDMEHEEFVRIFNGFRRHPGQKSNATTWVPAFNV-QIPDQVDWRTKGLVTPIKNQQQCGSCWAFSTTGSLEGQHKKKTGKLVSLSEQNLVDCSGPEGNQGCEGGLMDQAFEYIKDNKGIDTEDSYPYTAEDGTCHFKKSSVGATVTGYVDIPTGDEEALKQAVATVGPVSVAIDASQNSFQTYQDGIYDEPQCSSEFLDHGVLAVGYGTEDGSDYWLVKNSWGTTWGIKGYIKMSRNKNNQCGIATQASYPLV 331          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ctsl.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023607])

HSP 1 Score: 364.385 bits (934), Expect = 3.095e-125
Identity = 177/309 (57.28%), Postives = 229/309 (74.11%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFR---ANYLG-VSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K +FGK Y S+ E S R+L W  N K +  HN+  D G  +Y LG+  FADM N+E+R   A+ LG  +  + +  + F+       LP +VDWR KG+VT +K+Q+ CGSCW+FS TGSLEGQ +RKT  L+S SEQQLVDCSG +GN GC GGLMD AF+YI+   GI+ E +YPY A DG+C +    V  +CTGF DI  G+E+AL  AVAT+GPISVAIDA + SFQLY+SGIYNEP CSS++LDHGVLA+GYGT+NGK++WLVKNSWG+ WG +GYI+MS+++ NQCGI+TM+SYPLV
Sbjct:   25 EFHAWKLKFGKIYHSVEEESQRKLTWLTNRKLVLVHNMLADQGIKSYRLGMTFFADMDNKEYRKLFASCLGSFNRTKAHSATTFLRQTLRDPLPDTVDWRPKGYVTDIKDQKDCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNFGCGGGLMDQAFEYIKANKGIDTEDSYPYEAVDGDCRFKPDSVGATCTGFVDITSGDEKALQEAVATIGPISVAIDAGHSSFQLYESGIYNEPDCSSTELDHGVLAVGYGTDNGKDYWLVKNSWGLDWGNKGYIQMSRNEDNQCGIATMSSYPLV 333          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: si:dkey-26g8.5 (cathepsin L1-like [Source:NCBI gene;Acc:103028700])

HSP 1 Score: 358.607 bits (919), Expect = 7.348e-123
Identity = 175/319 (54.86%), Postives = 227/319 (71.16%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV--SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGN-CVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYG----TENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +++ +L+D W+ +K+   K Y    E  RRL+WE+NLK ++ HNLEH +GKHTY LG+N FADMTNEEFR    G   +P + +  S F+ P  +  +P  VDWR KG+VTPVK+Q +CGSCW+FS+TG+LEGQH+RKT  L+S SEQ LVDCS   GN GC+GG+M+ AFQY++   GI++E +YPYTA+D   C YD +    + TGF DIP G E AL  AVA VGP+SVAIDA + SFQ Y+SGIY E  CSS +LDHGVL +GYG     E+GK +W+VKNSW   WG  GYI M+KD+ N CGI++ ASYPL+
Sbjct:   21 SLDRQLDDHWKLWKSWHSKSYHEKEEGWRRLVWEKNLKKVELHNLEHSMGKHTYRLGMNQFADMTNEEFRQAMNGYRSNPNKKSKGSLFLEPSFL-EVPKQVDWREKGYVTPVKDQARCGSCWAFSSTGALEGQHFRKTGKLVSLSEQNLVDCSRPEGNQGCNGGIMEQAFQYVKDNGGIDSEESYPYTAKDDQPCRYDPNFNSANDTGFVDIPSGEEHALMKAVAAVGPVSVAIDAGHESFQFYQSGIYYEKACSSEELDHGVLVVGYGFEGADEDGKKYWIVKNSWSEKWGQNGYIYMAKDRKNHCGIASAASYPLM 338          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000042132.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 339.732 bits (870), Expect = 1.207e-115
Identity = 163/308 (52.92%), Postives = 213/308 (69.16%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV----SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K + GK Y    E  R++ W  N K +  HN+  D G  TY LG+ HFADM N+E+R    G     +  +    S F+       LP++VDWRT+G+VT VKNQ+ CGSCW+FS TG+LEGQ +RK   L+  SEQQLVDCS  +GN GC GG M+ AFQY++  G ++ E +YPY A +G C Y    V  +C+G+ DI  G+EQAL  AVATVGP+SVAID  +YSFQLY+SG+Y+EP CS+S L H VLA+GYG++ G+++WLVKNSWG  WG QGYIKMS+++ NQCGI+T ASYPLV
Sbjct:   25 EFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000048039.1 (cathepsin L1-like [Source:NCBI gene;Acc:103023924])

HSP 1 Score: 339.732 bits (870), Expect = 1.207e-115
Identity = 163/308 (52.92%), Postives = 213/308 (69.16%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV----SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A+K + GK Y    E  R++ W  N K +  HN+  D G  TY LG+ HFADM N+E+R    G     +  +    S F+       LP++VDWRT+G+VT VKNQ+ CGSCW+FS TG+LEGQ +RK   L+  SEQQLVDCS  +GN GC GG M+ AFQY++  G ++ E +YPY A +G C Y    V  +C+G+ DI  G+EQAL  AVATVGP+SVAID  +YSFQLY+SG+Y+EP CS+S L H VLA+GYG++ G+++WLVKNSWG  WG QGYIKMS+++ NQCGI+T ASYPLV
Sbjct:   25 EFHAWKLKLGKVYNPAEESQRKITWLANRKLVLVHNMLADQGLKTYRLGMTHFADMDNQEYRQMLQGCLGSFNETKAPGASSFLRQAGGATLPNTVDWRTQGYVTEVKNQEMCGSCWAFSATGALEGQMFRKLGYLLPLSEQQLVDCSREYGNMGCSGGWMNQAFQYVKDNGGLDTEDSYPYEAMEGYCRYYPDAVGATCSGYVDISIGDEQALQEAVATVGPVSVAIDVGHYSFQLYQSGVYDEPDCSTSALGHAVLAVGYGSDYGQDYWLVKNSWGTYWGDQGYIKMSRNKNNQCGIATAASYPLV 332          
BLAST of Cathepsin L2 vs. Ensembl Cavefish
Match: ENSAMXT00000034892.1 (cathepsin L1-like [Source:NCBI gene;Acc:107196839])

HSP 1 Score: 334.724 bits (857), Expect = 1.240e-113
Identity = 166/311 (53.38%), Postives = 218/311 (70.10%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMN-----FTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQ-QYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYG-TENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ ++K Q GK Y S  E S R++IW  N K + +HN+  D G  +Y LG+N F DM N+EF+A +     K  N      TS F++ E    LP  VDWR KG+VT VK+Q  CGSCW+FS TG+LEGQ +RKT  LIS SE+QLVDCS SFGN GC+GG    +F+YI+   G+EA+ TYPY  ++  C ++  +VV +C+GF  +P G+E AL  AVA +GPISVAID S ++FQLYKSG+Y+EP CSS++L+H V+ +GYG    GK +WLVKNSWGIGWG  GYIKMS+++ NQCGI+T A+YPLV
Sbjct:   26 EFNSWKLQHGKSYDSEEEESQRKMIWLNNRKLVLEHNMLADQGLKSYRLGMNIFGDMENQEFQAMF-SHCVKSFNETDSLCTSTFLSEEEDTPLPRRVDWRKKGYVTDVKDQMSCGSCWAFSATGALEGQMFRKTGKLISLSEKQLVDCSQSFGNRGCNGGWPSKSFEYIKSNQGLEADFTYPYKPREETCRFNPQRVVATCSGFECLPQGDENALKKAVAKIGPISVAIDTSKHTFQLYKSGVYDEPGCSSTRLNHAVVLVGYGNAPRGKQYWLVKNSWGIGWGDNGYIKMSRNKMNQCGIATDATYPLV 335          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000006499.1 (pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 gene:ENSPMAG00000005817.1 transcript:ENSPMAT00000006499.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 359.377 bits (921), Expect = 6.375e-124
Identity = 178/315 (56.51%), Postives = 225/315 (71.43%), Query Frame = 3
Query:  135 LNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRAN---YLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGN-CVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT----ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            L++EW ++K    K Y    E  RR+IWE+NL  I+ HNLEH LGKHT+ +G+NHF DMTNEEFR     Y GV P +++  S F+ P+N  A P +VDWR KG VT VK+Q +CGSCW+FSTTG+LEGQH RK   L+S SEQ LVDCS + GN GC GGLMD AFQY++   GI++E+ YPYT  DG+ C YD      + TGF D+  G+E+AL  AVA+VGP+SVAIDAS+ SFQ Y+SG+Y EP CSS  LDHGVL +GYG     ENGK +W+VKNSW   WG +GY+ M++++ N CGI+T ASYPLV
Sbjct:   26 LDEEWGSWKGFHQKLYEPKQESWRRMIWEKNLNKIKIHNLEHSLGKHTWRMGMNHFGDMTNEEFRQKMNGYHGVQPHKVSKGSTFLVPQNYEA-PPTVDWRDKGLVTEVKDQGECGSCWAFSTTGALEGQHMRKVGQLVSLSEQNLVDCSRAEGNQGCGGGLMDQAFQYVKDNGGIDSEAAYPYTGTDGDKCHYDPKFNSANDTGFVDVTSGDEKALKIAVASVGPVSVAIDASHESFQFYQSGVYFEPDCSSQDLDHGVLVVGYGVKGTGENGKKYWIVKNSWSPKWGDEGYVLMARNKKNHCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000011285.1 (pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gene:ENSPMAG00000010258.1 transcript:ENSPMAT00000011285.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 344.739 bits (883), Expect = 1.089e-118
Identity = 171/299 (57.19%), Postives = 215/299 (71.91%), Query Frame = 3
Query:  174 KKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV----SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENG-KNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            K Y    E  RR+IWE+NLK I  HNLEH +GKHT+ +G+N F DMT EEF+   LG+       + +  + F+AP    A P SVDWR +G+VT VK+Q  CGSCW+FSTTGSLEGQH RKT  L+S SEQ LVDCS + GNNGC GGLMD AF YI++  GI++E++YPYTA+D NC Y+        TGF DIP GNE+AL +AVA+VGP+S+ IDAS  SFQLY SGIY++  CS++ LDHGVL +GYG ++  + FW+VKNSWG  WG  GYI M++D+ N CGI+T ASYPLV
Sbjct:    1 KTYDQNEEGWRRMIWEKNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTKEEFQHTMLGLRGSNDTSKASRGATFMAPAFFKA-PESVDWRKQGYVTDVKDQGDCGSCWAFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSAEGNNGCKGGLMDLAFTYIKKNGGIDSEASYPYTAKDENCKYNPKNKAAEDTGFVDIPSGNEEALKNAVASVGPVSIGIDASLESFQLYSSGIYSDSDCSNN-LDHGVLVVGYGVDDDERKFWIVKNSWGTKWGDHGYILMARDKDNLCGIATAASYPLV 297          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000010475.1 (pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 gene:ENSPMAG00000009483.1 transcript:ENSPMAT00000010475.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 332.028 bits (850), Expect = 6.933e-114
Identity = 167/291 (57.39%), Postives = 208/291 (71.48%), Query Frame = 3
Query:  204 RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH------FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            RR+IWE+NLK I  HNLEH +GKHT+ +G+N F+DMT EEF+   LG   +  N TS       F+AP    A P SVDWR +G+VT +KNQ  CGSCWSFSTTGSLEGQH RKT  L+S SEQ LVDCS + GN+GC+GGLM +AF YI++  GI++E +YPY  Q   C YD        TG+ +IP G+E+AL +AVA+VGP+SVAIDAS  SFQ Y SGIY +  C S  +DH VL +GYG  E G+ FWLVKNSWG+ WG QGY++M++D  N CGI+TM+SYPLV
Sbjct:    7 RRIIWEKNLKRISVHNLEHSMGKHTWRMGMNQFSDMTGEEFQQVMLGF--RGWNGTSKAPRGATFMAPAFFEA-PESVDWRKQGYVTDIKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNHGCNGGLMINAFNYIKKNGGIDSEESYPYKGQVETCKYDPKNKAAEVTGYVEIPEGDEEALMNAVASVGPVSVAIDASLASFQSYGSGIYKDAMC-SHHIDHAVLVVGYGVDEMGQKFWLVKNSWGVTWGEQGYVRMARDDNNLCGIATMSSYPLV 293          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000008535.1 (pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 gene:ENSPMAG00000007699.1 transcript:ENSPMAT00000008535.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 322.013 bits (824), Expect = 4.049e-109
Identity = 161/319 (50.47%), Postives = 220/319 (68.97%), Query Frame = 3
Query:  126 NSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRAN---YLGVSPKRM--NFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYI-QQYGIEAESTYPYTAQD-GNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT----ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPL 1049
            +  L+  WEA+   F K Y   + I RRLIWE+N++++ +HNLEH LG H+YTLG+NH AD+T +EFR     Y   S +R   + TS F+APEN   +P S+DWR +G VTP+KNQ QCGSCW+FS+TG+LEGQ  R++  L+  SEQ L+DCS   G  GC GG MD AFQY+  Q GI++ES YPYTA D  +C YD S++V   +GF DI  G+E+ L +AVA+VGP+SVAIDA + SFQLY+SGIY EP+C+ ++LDH VL +G+G     ENGK FW+VKN  G+  G + Y++++ D+   CG+  + +  L
Sbjct:   29 DPALDGHWEAWTVYFKKAYTQTDGIKRRLIWEENMRFVDRHNLEHSLGLHSYTLGMNHLADLTVDEFRKTMNGYRRGSRERHEGHHTSTFLAPENY-EVPQSMDWRDQGLVTPIKNQGQCGSCWAFSSTGALEGQWKRRSGELVPLSEQNLLDCSRPEGTEGCGGGWMDDAFQYVLDQGGIDSESDYPYTATDVDSCHYDPSRMVARISGFVDIHKGSEKDLITAVASVGPVSVAIDAGHQSFQLYESGIYYEPECNCTELDHAVLVVGFGVKGRGENGKKFWIVKNRRGLQCGGEIYLEVAVDKRCFCGLYQIMNVTL 346          
BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000003800.1 (pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 gene:ENSPMAG00000003453.1 transcript:ENSPMAT00000003800.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 315.079 bits (806), Expect = 3.602e-107
Identity = 164/292 (56.16%), Postives = 202/292 (69.18%), Query Frame = 3
Query:  204 RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSH------FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQD-GNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGT-ENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            RR+IWEQNLK I  HNLEH +GKHT+ +G+N F DMT EEF+   LG   +  N TS       F+AP    A P SVDWR +G+VT VKNQ  CGSCWSFSTTGSLEGQH RKT  L+S SEQ LVDCS + GN GC+GGLM +AF YI++  GI++E +YPY  Q    C Y+        TG+ +IP G+E+AL +AVA+VGP+SVAIDAS  SF  Y SGIY +  CS   ++H VL +GYG  E G  FWLVKNSWG+ WG +GY++M++D  N CGI+  ASYPLV
Sbjct:    8 RRMIWEQNLKKIAVHNLEHSMGKHTWRMGMNRFGDMTGEEFQQVMLGF--RGWNGTSKAPRGATFMAPAFFEA-PESVDWRKQGYVTDVKNQGDCGSCWSFSTTGSLEGQHKRKTGVLVSLSEQNLVDCSSTEGNYGCNGGLMINAFNYIKKNGGIDSEESYPYKGQGVETCKYNPKNKAAEVTGYVEIPEGDEEALKNAVASVGPVSVAIDASLNSFLYYISGIYKDKLCSHI-INHAVLVVGYGVDEKGDKFWLVKNSWGVQWGEKGYVRMARDDNNLCGIAVTASYPLV 295          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO46465 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RPY5])

HSP 1 Score: 370.933 bits (951), Expect = 2.455e-128
Identity = 179/311 (57.56%), Postives = 227/311 (72.99%), Query Frame = 3
Query:  129 SEL--NDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            SEL  + +W A+K   GK Y    E  RR IW  NL+ +++HN E+    H+Y L +NHFAD+T  EF+  ++G      +       P +   LP+ VDWR KGFVT VKNQ QCGSCW+FS+TGSLEGQH+RKT  L+S SEQ LVDCS  +GNNGC+GGLMD AF+YI+   GI+ E +YPYTA+DG C +    V  + TG++D+  G+E  L SAVATVGPISVAIDA + SFQLYK+G+Y+EP CSS+QLDHGVLA+GYG E+GK++WLVKNSWG GWG+ GYIKMS+++ NQCGI+T ASYPLV
Sbjct:   19 SELSQDRQWHAWKDFHGKTYTGEEEDLRRAIWNDNLEIVKKHNAEN----HSYKLDMNHFADLTVTEFKQRFMGYRAASNSTGGSTFLPLSNVQLPAEVDWRDKGFVTAVKNQGQCGSCWAFSSTGSLEGQHFRKTGKLVSLSEQNLVDCSKKYGNNGCEGGLMDYAFKYIKNNDGIDTEQSYPYTARDGQCHFKPGSVGATVTGYTDVQRGSEGDLQSAVATVGPISVAIDAGHSSFQLYKTGVYSEPDCSSTQLDHGVLAVGYGAEDGKDYWLVKNSWGEGWGMNGYIKMSRNKDNQCGIATQASYPLV 325          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45953 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRH6])

HSP 1 Score: 361.688 bits (927), Expect = 9.597e-125
Identity = 180/312 (57.69%), Postives = 231/312 (74.04%), Query Frame = 3
Query:  138 NDEWEAYKTQFGKKYVSLNEISRRL-IWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGV-----SPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            + EW A+K+  GK Y  ++E   R+ IW+QNL+ I++HN E     H+Y + +NH  D+T +EFR  YLGV     S KR   T  ++ P NV  +PSSVDW  KG+VT VKNQ QCGSCW+FSTTGS+EGQH+RKT +L+S SEQ L+DCSGS+GNNGC GGLMD+AF+YI+   GI+ ES+YPY  Q G+C +  S V    TG+ DIP G+EQAL SAVATVGP+SVA+DAS +  Q Y SG+Y+ P CSS+QLDHGVL IGYG  NG+++WLVKNSWG  WG++GYI MS+++ NQCGI++ ASYPLV
Sbjct:   24 DSEWVAWKSYHGKSYSDVHEERTRMAIWQQNLEKIKRHNAE----DHSYKMAMNHLGDLTEDEFRYFYLGVRAHHNSTKRGWAT--YMPPSNV-KIPSSVDWSQKGYVTGVKNQGQCGSCWAFSTTGSVEGQHFRKTGSLVSLSEQNLIDCSGSYGNNGCQGGLMDNAFRYIESNGGIDTESSYPYLGQQGSCHFSSSHVGARVTGYQDIPQGSEQALQSAVATVGPVSVAVDASQW--QFYSSGVYDNPYCSSTQLDHGVLVIGYGNYNGQDYWLVKNSWGYSWGVEGYIMMSRNKNNQCGIASSASYPLV 326          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO45852 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRL9])

HSP 1 Score: 357.836 bits (917), Expect = 4.252e-123
Identity = 170/308 (55.19%), Postives = 229/308 (74.35%), Query Frame = 3
Query:  147 WEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            W+A+K+  GK+Y + NE + R  IW+ NLK I  HN     GKH++ L +NH  DMT+ E     LG+  K+   +    + F+ P NV  +  S+DWR+KG+VTPVKNQ QCGSCW+FSTTG+LEGQH+RKT  L+S SEQ LVDCSG +GNNGC+GGLMD+AFQYI++ G I+ E +YPY A+DG C Y+KS +    TGF DIP G+E AL  A+A+VGPIS+AIDAS  +F  Y  G+Y++P CSS++LDHGVLA+GYGT++GK++WLVKNSWG  WG +GYIK++++  ++CG+++ ASYPLV
Sbjct:   29 WKAWKSFHGKEYPNKNEETMRNFIWQNNLKKIVTHNE----GKHSFKLAMNHLGDMTSLEISQTLLGLKLKKHAESQPKGATFLPPANVKVV-DSIDWRSKGYVTPVKNQGQCGSCWAFSTTGALEGQHFRKTGKLVSLSEQNLVDCSGKYGNNGCEGGLMDNAFQYIKENGGIDTEKSYPYLAKDGVCHYNKSAIGAKDTGFVDIPTGDENALQQALASVGPISIAIDASQSTFHFYHQGVYDDPDCSSTRLDHGVLAVGYGTDDGKDYWLVKNSWGPSWGEEGYIKIARNDHDKCGVASKASYPLV 331          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO36727 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SHX1])

HSP 1 Score: 356.681 bits (914), Expect = 9.110e-123
Identity = 172/313 (54.95%), Postives = 226/313 (72.20%), Query Frame = 3
Query:  132 ELNDEWEAYKTQFGKKYVSLNEI-SRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E   +W+A+K    KKY ++ E  +R+ IW  NLK IQ+HN E     H++TL +NH  D+T +EFR  Y G+     N+T    S F+AP +V  +P +VDWR +G+VTPVKNQ QCGSCW+FSTTGSLEGQ+++KT  L+S SEQ LVDCS ++GNNGC GGLMD AF+YI++ G I+ E +YPY A++  C + KS +    TGF D+ HG+E+AL +A  TVGPISVAIDA + SFQ Y SG+YN   CSS+ LDHGVL +GYGT  G ++WLVKNSWG  WG++GYI MS+++ NQCG++T ASYPLV
Sbjct:   23 EDEQQWQAWKLFHTKKYTTVTEEGARKAIWRDNLKKIQKHNAE----GHSFTLAMNHLGDLTQDEFRYFYTGMRSHYSNYTKKQGSAFLAPSHV-QVPDTVDWRKEGYVTPVKNQGQCGSCWAFSTTGSLEGQNFKKTGKLVSLSEQNLVDCSTAYGNNGCQGGLMDYAFKYIKENGGIDTEESYPYEARNDRCRFQKSNIGAVDTGFVDVTHGDEEALKTAAGTVGPISVAIDAGHMSFQFYHSGVYNNAGCSSTSLDHGVLVVGYGTYQGSDYWLVKNSWGERWGMEGYIMMSRNKNNQCGVATQASYPLV 330          
BLAST of Cathepsin L2 vs. Ensembl Nematostella
Match: EDO41322 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S4P4])

HSP 1 Score: 228.024 bits (580), Expect = 7.033e-70
Identity = 121/296 (40.88%), Postives = 175/296 (59.12%), Query Frame = 3
Query:  201 SRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRA--------NYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQY-GIEAESTY-PYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQC--SSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            +RR  ++ NL++I   N  H      Y L +NH  D +++E R          Y G  P + +  S       +  +P  ++W  +G VTPVK+Q  CGSCWSF TTG++EG  + KT+ L   S+Q L+DCS   GNN CDGG    ++QYI +  GI  E +Y PY   DG C    +++  + TG+ +I  G+  AL +A+A  GPISV+IDAS+ S   Y  G+Y EP+C   +  LDH VLA+GYGT +GK +W++KNSW   WG+ GY+ MS+ + N CG++T A+Y L+
Sbjct:  264 TRREHFKHNLRFIHSKNRRH----AGYYLAMNHLGDRSDKELRVLRGRRYTKGYNGGLPYKPDMAS-------INDVPDEMNWVIRGAVTPVKDQAVCGSCWSFGTTGTIEGTLFLKTKYLTRLSQQNLMDCSWGEGNNACDGGEDFRSYQYIMKSGGIATEESYGPYLGADGYCHKKDAEIGATITGYVNITEGDLSALKTAIAQKGPISVSIDASHKSLSFYSYGVYYEPKCGNKNEDLDHSVLAVGYGTMDGKPYWMIKNSWSTHWGMNGYVLMSQ-KDNNCGVATAATYVLM 547          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl.1 (cathepsin L1 [Source:NCBI gene;Acc:101171789])

HSP 1 Score: 369.777 bits (948), Expect = 3.142e-127
Identity = 180/313 (57.51%), Postives = 229/313 (73.16%), Query Frame = 3
Query:  144 EWEAYKTQFGKKYVS-LNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFR--------ANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            E+ A++ +FG+ Y S   E  RR  W  N K +  HN+  D G  +Y LG+ +FADM NEE++         ++    P+R   ++ F  PEN   LP++VDWR KG+VT VK+Q+QCGSCW+FS TGSLEGQ +RKT  L+S SEQQLVDCSG +GN GC GGLMD AF+YIQ  G I+ E +YPY A+DG C Y    V  +CTG+ D+  G+E AL  AVAT+GPISV IDAS+ SFQLY+SG+Y+EPQCSSS+LDHGVLA+GYG+ENG+++WLVKNSWG+ WG QGYIKMSK++ NQCGI+T ASYPLV
Sbjct:   30 EFHAWRLKFGRTYSSPTEEAQRRQTWLNNRKLVLVHNILADQGIKSYRLGMTYFADMENEEYKRLISQGCLGSFNASLPRRG--STFFRLPENKD-LPAAVDWRDKGYVTDVKDQKQCGSCWAFSATGSLEGQTFRKTGKLVSLSEQQLVDCSGDYGNMGCGGGLMDDAFRYIQATGGIDTEESYPYEAEDGECRYKPDAVGATCTGYVDVSSGDEDALQEAVATIGPISVGIDASHISFQLYESGLYDEPQCSSSELDHGVLAVGYGSENGQDYWLVKNSWGLTWGDQGYIKMSKNKSNQCGIATAASYPLV 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsl (cathepsin L [Source:NCBI gene;Acc:100049246])

HSP 1 Score: 348.206 bits (892), Expect = 7.616e-119
Identity = 174/319 (54.55%), Postives = 221/319 (69.28%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFR--ANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQ-YGIEAESTYPYTAQDGN-CVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE----NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            T++ +L+  W+ +K    K Y    E  RRL+WE+NL+ I+ HNLEH +GKH+Y LG+NHF DMT+EEFR   N      +R    S F+ P N    P +VDWR KG+VTPVK+Q QCGSCW+FSTTG+LEGQ +RKT  L+S SEQ LVDCS   GN GC+GGLMD AFQY++   G+++E  YPY   D   C Y+      + TGF DIP G E+AL  AVA+VGP+SVAIDA + SFQ Y+SGIY E +CSS +LDHGVL +GYG E    +GK +W+VKNSW   WG +G+I M+KD+ N CGI+T ASYPLV
Sbjct:   19 TLDPQLDQHWQLWKGWHSKNYHEKEEGWRRLVWEKNLRKIELHNLEHSMGKHSYRLGMNHFGDMTHEEFRQIMNGYKRREQRKYSGSLFMEP-NFLEAPRAVDWRDKGYVTPVKDQGQCGSCWAFSTTGALEGQQFRKTGKLVSLSEQNLVDCSRPEGNEGCNGGLMDQAFQYVKDNQGLDSEDFYPYKGTDDQPCQYNAQYSAVNDTGFVDIPSGKERALMKAVASVGPVSVAIDAGHESFQFYQSGIYFEKECSSDELDHGVLVVGYGFEGEDVDGKKYWIVKNSWSEKWGDKGFIYMAKDRHNHCGIATAASYPLV 336          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss (cathepsin S [Source:NCBI gene;Acc:100049247])

HSP 1 Score: 298.13 bits (762), Expect = 2.838e-99
Identity = 148/314 (47.13%), Postives = 201/314 (64.01%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYV-SLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLG-VSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQY-IQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
             + S L+  W  +K  + K Y   + E  RR IWE+NL+ I  HNLE  LG H+Y L +NH  D+T EE  A+  G V+P  +    + +   N  ++P SVDWR  G VT VK Q +CGSCW+FS  G+LEGQ  + T  L S S Q LVDCS  +GN GC GG M +AFQY I+  GI +++ YPY  +   C YD      +CTG++ +P G+E AL   VAT+GPISVAIDAS   F  Y+ G+Y +  CS + ++HGVL +GYGTENG+++WLVKNSWG  +G  GYIKM++++ NQCGI+  A +P++
Sbjct:   16 AVRSHLDQHWNLWKKTYSKTYSHEIEEFGRRRIWEENLEMISVHNLEVSLGLHSYELAMNHLGDLTIEELIASLTGTVAPVGLERIHYDLVKINT-SVPESVDWREGGLVTSVKTQGRCGSCWAFSAVGALEGQLKKTTGILTSLSPQNLVDCSTKYGNYGCKGGFMSNAFQYVIKNQGISSDAAYPYIGKRDKCKYDSKHRAANCTGYNFLPKGDEFALKVGVATIGPISVAIDASRPKFLFYRHGVYKDHSCSHN-VNHGVLVVGYGTENGEDYWLVKNSWGERYGDGGYIKMARNRRNQCGIALYACFPVM 327          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctss2.1 (cathepsin S [Source:NCBI gene;Acc:101165175])

HSP 1 Score: 296.975 bits (759), Expect = 1.009e-98
Identity = 144/315 (45.71%), Postives = 199/315 (63.17%), Query Frame = 3
Query:  120 TINSELNDEWEAYKTQFGKKYVSLNE-ISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPK-RMNFTSH-FIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQY-IQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
              +S L+  WE +K    K Y S  E + RR +WE+NL  I  HNLE+ +G HTY L +NH  D+T EE    +  + P   +    H F+       +P  +DWR K  VT VK Q  CGSCW+FS  G+LEGQ  RKT  L+  S Q LVDCS  +GN+GC+GG M  AFQY I   GI++++ YPY     NC Y       +C+ +S +P G+E AL  A+AT+GPISVAIDA+   F  Y+SG+Y++  CS + ++HGVLA+GYGT NG+++WLVKNSWG  +G QGYI+M++++ +QCGI+    YP++
Sbjct:   26 AFDSRLDIHWELWKKTHSKHYPSEEEDVHRRDLWERNLMLITMHNLEYSMGLHTYDLSMNHMGDLTQEEILQQFASLRPPTNLKREPHLFVGASGSNNIPDEMDWRQKNCVTSVKMQGSCGSCWAFSAVGALEGQLCRKTGKLVDLSPQNLVDCSSKYGNHGCNGGFMHQAFQYVIDNQGIDSDAGYPYVGVTQNCHYSSEYRAANCSQYSFLPEGDEGALKEAIATIGPISVAIDATRPRFAFYRSGVYDDSSCSQN-VNHGVLAVGYGTLNGQDYWLVKNSWGTTFGEQGYIRMARNKNDQCGIAMYGCYPIM 339          
BLAST of Cathepsin L2 vs. Ensembl Medaka
Match: ctsk (cathepsin K [Source:NCBI gene;Acc:101164922])

HSP 1 Score: 292.352 bits (747), Expect = 5.103e-97
Identity = 148/315 (46.98%), Postives = 202/315 (64.13%), Query Frame = 3
Query:  129 SELNDEWEAYKTQFGKKYVSLNEIS-RRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAP-ENVGAL---PSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYG-IEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTE-NGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            + L+  WE +K    K+Y+++ E   RR IWE+NL+ I+ HN E  LG HTYTLG+N F DMT EE      G+   +M        P E  G+L   P SVD+R KG VT VKNQ  CGSCW+FS+ G+LEGQ  +KT NL+  S Q LVDC     N+GC GG M +AF+Y+Q+ G I++E+ YPY  +D  C Y+ S +     G+ ++P G+E ALA A+   GP+SV IDAS  SF  Y+ GIY +  C+   ++H VLA+GYG    GK FW+VKNSWG  WG +GY+ M++++GN CGI+ +ASYP++
Sbjct:   22 TTLDAHWEEWKMTHTKEYITVEEEGIRRAIWEKNLRMIEAHNQEAALGMHTYTLGMNQFGDMTQEEVVERMTGL---QMPLNPEPRVPMETDGSLIKLPKSVDYRKKGMVTSVKNQGSCGSCWAFSSVGALEGQLAKKTGNLVDLSPQNLVDCVTE--NDGCGGGYMTNAFKYVQENGGIDSEAAYPYMGEDQPCRYNVSGLAAQIKGYKEVPEGDEHALAVALFKAGPVSVGIDASQNSFLYYQKGIYFDRNCNKEDINHAVLAVGYGVNAKGKKFWIVKNSWGETWGNKGYVLMARNRGNVCGIANLASYPVM 331          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049723.1 (SMESG000049723.1)

HSP 1 Score: 665.996 bits (1717), Expect = 0.000e+0
Identity = 331/332 (99.70%), Postives = 332/332 (100.00%), Query Frame = 3
Query:   57 MQIIIXXXXXXXXXXXXPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            MQIIILVSLFLAAVSAAPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGI+TMASYPLV
Sbjct:    1 MQIIILVSLFLAAVSAAPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGIATMASYPLV 332          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014166.1 (SMESG000014166.1)

HSP 1 Score: 505.368 bits (1300), Expect = 0.000e+0
Identity = 230/313 (73.48%), Postives = 274/313 (87.54%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLG-VSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            F++NSELN++WE YKTQF ++Y  L EI+RR+IWEQNL+YI+QHNLE+DLGKHTY LGLN +AD+TNEEF+A +LG +  +     S F+APEN+GALP++VDWRTKG+VTPVKNQQQCGSCW+FSTTGSLEGQH+RKT +L+SFSEQQLVDCSG++GN GC GGLMD+AF YI +YG+E+E  YPYTA DG C YD+SKVVG+C+GF+DI HGNE  LA AVATVGP+SVAIDAS+YSFQLYK GIYNEPQCS  QLDHGVLA+GYG+ENG N+WLVKNSWGI WG+ GYIKMSKD+ NQCGIST AS+PLV
Sbjct:   22 FSLNSELNEDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLGKILTRSSTKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRKNQCGISTSASFPLV 334          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014167.1 (SMESG000014167.1)

HSP 1 Score: 504.212 bits (1297), Expect = 1.431e-180
Identity = 230/313 (73.48%), Postives = 273/313 (87.22%), Query Frame = 3
Query:  117 FTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLG-VSPKRMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            F++NSELN +WE YKTQF ++Y  L EI+RR+IWEQNL+YI+QHNLE+DLGKHTY LGLN +AD+TNEEF+A +LG +  +     S F+APEN+GALP++VDWRTKG+VTPVKNQQQCGSCW+FSTTGSLEGQH+RKT +L+SFSEQQLVDCSG++GN GC GGLMD+AF YI +YG+E+E  YPYTA DG C YD+SKVVG+C+GF+DI HGNE  LA AVATVGP+SVAIDAS+YSFQLYK GIYNEPQCS  QLDHGVLA+GYG+ENG N+WLVKNSWGI WG+ GYIKMSKD+ NQCGIST AS+PLV
Sbjct:   21 FSLNSELNKDWELYKTQFKRQYEPLTEITRRIIWEQNLEYIRQHNLEYDLGKHTYYLGLNEYADLTNEEFKAKFLGKILTRSSRKGSQFMAPENMGALPTTVDWRTKGYVTPVKNQQQCGSCWAFSTTGSLEGQHFRKTGSLVSFSEQQLVDCSGAYGNEGCGGGLMDNAFNYIMKYGLESERDYPYTATDGKCKYDRSKVVGTCSGFTDIKHGNESDLAVAVATVGPVSVAIDASHYSFQLYKGGIYNEPQCSPDQLDHGVLAVGYGSENGGNYWLVKNSWGISWGLSGYIKMSKDRNNQCGISTSASFPLV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000049722.1 (SMESG000049722.1)

HSP 1 Score: 476.093 bits (1224), Expect = 1.922e-169
Identity = 226/333 (67.87%), Postives = 269/333 (80.78%), Query Frame = 3
Query:   57 MQIIIXXXXXXXXXXXXPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT-SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            M+I++L    + ++SA   +F +N  LN+EW  YK QF +KY S+ E++RRLIWE+NL+ IQ+HN+E+DLGKH+Y LGLN FADMTNEE+R   LG+ P   N+T + F+APEN   LP SVDWRTKG+VTPVKNQ  CGSCWSFSTTGSLEGQH RKT  LIS SEQQLVDCS  FGNNGC+GGLMD+AFQYIQ+YG+E+E+ Y YTA++GNC YD SKVV  CTGF DI  GNE+ LA AVATVGPISVAIDAS  +FQLYK GIYNE  CSS QLDHGVLA+GYG EN ++FW+VKNSWG  WG+ GYIKM+KD+ NQCGI+TMASYPLV
Sbjct:    1 MKIVLLAVFCVVSISAGKLKFEVNEALNEEWNMYKIQFQRKYESIIELTRRLIWEENLRLIQKHNIEYDLGKHSYYLGLNEFADMTNEEYRVKVLGLKPINKNYTRTIFLAPENTVDLPKSVDWRTKGYVTPVKNQANCGSCWSFSTTGSLEGQHKRKTGQLISLSEQQLVDCSKPFGNNGCNGGLMDNAFQYIQKYGLESEADYSYTAKEGNCKYDASKVVAHCTGFVDIKKGNEKDLAKAVATVGPISVAIDASKPTFQLYKGGIYNEKSCSSRQLDHGVLAVGYGKENNQHFWIVKNSWGPQWGLSGYIKMTKDRHNQCGIATMASYPLV 333          
BLAST of Cathepsin L2 vs. Planmine SMEST
Match: SMESG000014171.1 (SMESG000014171.1)

HSP 1 Score: 420.624 bits (1080), Expect = 1.778e-147
Identity = 204/336 (60.71%), Postives = 257/336 (76.49%), Query Frame = 3
Query:   57 MQIIIXXXXXXXXXXXXPQQFTINSELNDEWEAYKTQFGKKYVSLNEISRRLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPKRMNFT----SHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSLEGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEAESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISVAIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNSWGIGWGIQGYIKMSKDQGNQCGISTMASYPLV 1052
            M+  I++SLFL A+ A P++FT+NSELN+EWE +K QF K+Y  L E+ RR+IWE+NL +I+QHNLE+DLGKH+YTLGLN ++D+TN EF+A  LG    R+N +    S F+ PEN+GALPSSVDWRTKG+VTPVKNQ  CGSCW+FS TG+LEGQH+RKT  LIS SEQQLVDCS  +GN GC GG    AF Y+ +YG+E+E  Y Y  ++  C+YDKSKVV + T ++    GNE  LA+AVATVGP+S+ IDA +  FQ YK+GIYN P CSS  LDH VL +GYG+ NG N+W+VKNSWG  WGI+GYI MSKD+ NQCGI+T A YP+V
Sbjct:    1 MKAFIILSLFLVAIEAGPRRFTVNSELNEEWELFKAQFHKQYEPLTEVMRRIIWEENLDFIRQHNLEYDLGKHSYTLGLNEYSDLTNAEFKAKLLG---NRLNGSNSKGSEFMVPENIGALPSSVDWRTKGYVTPVKNQYTCGSCWAFSATGALEGQHFRKTGKLISLSEQQLVDCSRPYGNLGCGGGFPYQAFDYVNKYGMESEDDYIYRNKENKCIYDKSKVVANFTSYTFTKPGNESDLAAAVATVGPLSIGIDADHPGFQHYKNGIYNNPTCSSEYLDHAVLVVGYGSLNGNNYWIVKNSWGPHWGIEGYILMSKDKDNQCGIATQAVYPVV 333          
The following BLAST results are available for this feature:
BLAST of Cathepsin L2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 5
Match NameE-valueIdentityDescription
CTSL4.046e-11353.31cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSL4.046e-11353.31cathepsin L [Source:HGNC Symbol;Acc:HGNC:2537][more]
CTSV3.517e-11152.38cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSV3.517e-11152.38cathepsin V [Source:HGNC Symbol;Acc:HGNC:2538][more]
CTSK4.527e-10851.29cathepsin K [Source:HGNC Symbol;Acc:HGNC:2536][more]
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BLAST of Cathepsin L2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 5
Match NameE-valueIdentityDescription
cpl-16.421e-10749.36CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-11.422e-7956.57CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
cpl-11.422e-7956.57CathePsin L family [Source:UniProtKB/TrEMBL;Acc:H... [more]
tag-1961.579e-5637.83pep chromosome:WBcel235:V:8594914:8597500:1 gene:W... [more]
tag-1961.579e-5637.83pep chromosome:WBcel235:V:8594914:8597469:1 gene:W... [more]
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BLAST of Cathepsin L2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Cp11.019e-11051.09gene:FBgn0013770 transcript:FBtr0087592[more]
Cp11.481e-11051.09gene:FBgn0013770 transcript:FBtr0087593[more]
Cp14.107e-10752.32gene:FBgn0013770 transcript:FBtr0339955[more]
Cp15.215e-10060.79gene:FBgn0013770 transcript:FBtr0304021[more]
CG53671.150e-7238.06gene:FBgn0032228 transcript:FBtr0080055[more]
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BLAST of Cathepsin L2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.11.344e-12958.39cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.11.344e-12958.39cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsl.11.344e-12958.39cathepsin L.1 [Source:ZFIN;Acc:ZDB-GENE-040718-61][more]
ctsla1.154e-12455.35cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106][more]
ctsla1.154e-12455.35cathepsin La [Source:ZFIN;Acc:ZDB-GENE-030131-106][more]
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BLAST of Cathepsin L2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
fcrl21.141e-12255.84Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
fcrl21.721e-12255.84Fc receptor-like 2 [Source:Xenbase;Acc:XB-GENE-590... [more]
lrfn41.854e-10650.69leucine rich repeat and fibronectin type III domai... [more]
lrfn41.634e-10550.69leucine rich repeat and fibronectin type III domai... [more]
lrfn41.605e-10350.35leucine rich repeat and fibronectin type III domai... [more]
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BLAST of Cathepsin L2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 5
Match NameE-valueIdentityDescription
Ctsl6.328e-11254.55cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsl6.328e-11254.55cathepsin L [Source:MGI Symbol;Acc:MGI:88564][more]
Ctsk3.246e-10849.68cathepsin K [Source:MGI Symbol;Acc:MGI:107823][more]
Ctsll39.901e-10750.16cathepsin L-like 3 [Source:MGI Symbol;Acc:MGI:1917... [more]
BC0516652.066e-10449.52cDNA sequence BC051665 [Source:MGI Symbol;Acc:MGI:... [more]
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BLAST of Cathepsin L2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P25782|CYSP2_HOMAM2.338e-11854.93Digestive cysteine proteinase 2 OS=Homarus america... [more]
sp|Q24940|CATLL_FASHE1.043e-11350.65Cathepsin L-like proteinase OS=Fasciola hepatica O... [more]
sp|Q9GKL8|CATL1_CHLAE1.512e-11253.31Cathepsin L1 OS=Chlorocebus aethiops OX=9534 GN=CT... [more]
sp|P07711|CATL1_HUMAN1.943e-11253.31Cathepsin L1 OS=Homo sapiens OX=9606 GN=CTSL PE=1 ... [more]
sp|P07154|CATL1_RAT2.021e-11154.02Cathepsin L1 OS=Rattus norvegicus OX=10116 GN=Ctsl... [more]
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BLAST of Cathepsin L2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
A0A2U8U4471.901e-17771.77Cathepsin L2 OS=Dugesia japonica OX=6161 PE=2 SV=1[more]
A0A267H1I61.564e-14262.74Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A1I8GVB71.745e-14262.74Uncharacterized protein OS=Macrostomum lignano OX=... [more]
A0A0L8HPF91.027e-13358.84Uncharacterized protein OS=Octopus bimaculoides OX... [more]
A0A4Y2J2Y63.546e-13358.99Cathepsin L OS=Araneus ventricosus OX=182803 GN=Cp... [more]
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BLAST of Cathepsin L2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.13.095e-12557.28cathepsin L1-like [Source:NCBI gene;Acc:103023607][more]
si:dkey-26g8.57.348e-12354.86cathepsin L1-like [Source:NCBI gene;Acc:103028700][more]
ENSAMXT00000042132.11.207e-11552.92cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ENSAMXT00000048039.11.207e-11552.92cathepsin L1-like [Source:NCBI gene;Acc:103023924][more]
ENSAMXT00000034892.11.240e-11353.38cathepsin L1-like [Source:NCBI gene;Acc:107196839][more]
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BLAST of Cathepsin L2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ENSPMAT00000006499.16.375e-12456.51pep scaffold:Pmarinus_7.0:GL477089:42202:47941:1 g... [more]
ENSPMAT00000011285.11.089e-11857.19pep scaffold:Pmarinus_7.0:GL499136:454:1347:-1 gen... [more]
ENSPMAT00000010475.16.933e-11457.39pep scaffold:Pmarinus_7.0:GL482653:10321:33550:-1 ... [more]
ENSPMAT00000008535.14.049e-10950.47pep scaffold:Pmarinus_7.0:GL478103:36116:54424:1 g... [more]
ENSPMAT00000003800.13.602e-10756.16pep scaffold:Pmarinus_7.0:GL485125:12828:20107:1 g... [more]
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BLAST of Cathepsin L2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Cathepsin L2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 5
Match NameE-valueIdentityDescription
EDO464652.455e-12857.56Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO459539.597e-12557.69Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO458524.252e-12355.19Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO367279.110e-12354.95Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
EDO413227.033e-7040.88Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Cathepsin L2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 5
Match NameE-valueIdentityDescription
ctsl.13.142e-12757.51cathepsin L1 [Source:NCBI gene;Acc:101171789][more]
ctsl7.616e-11954.55cathepsin L [Source:NCBI gene;Acc:100049246][more]
ctss2.838e-9947.13cathepsin S [Source:NCBI gene;Acc:100049247][more]
ctss2.11.009e-9845.71cathepsin S [Source:NCBI gene;Acc:101165175][more]
ctsk5.103e-9746.98cathepsin K [Source:NCBI gene;Acc:101164922][more]
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BLAST of Cathepsin L2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 5
Match NameE-valueIdentityDescription
SMESG000049723.10.000e+099.70SMESG000049723.1[more]
SMESG000014166.10.000e+073.48SMESG000014166.1[more]
SMESG000014167.11.431e-18073.48SMESG000014167.1[more]
SMESG000049722.11.922e-16967.87SMESG000049722.1[more]
SMESG000014171.11.778e-14760.71SMESG000014171.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018252 ID=SMED30018252|Name=Cathepsin L2|organism=Schmidtea mediterranea sexual|type=transcript|length=1107bp
ATTAACAATCCTACAGTATATAAGTGATGTGAAATCCTTTCAAACTCATT
GAGACAATGCAAATCATCATCCTTGTATCTCTATTCCTTGCCGCAGTAAG
TGCCGCTCCACAGCAGTTCACAATCAACAGTGAACTCAACGACGAATGGG
AAGCCTACAAAACCCAATTCGGAAAAAAGTACGTCTCTTTGAATGAAATC
TCAAGACGACTTATTTGGGAACAAAATTTGAAATATATTCAACAACACAA
TCTTGAGCACGATCTCGGAAAACACACTTACACACTCGGATTGAATCATT
TCGCTGACATGACCAACGAGGAATTCCGGGCGAATTATTTGGGAGTGTCA
CCAAAACGAATGAACTTCACATCACATTTCATTGCCCCAGAAAATGTGGG
AGCTTTGCCAAGTTCTGTGGATTGGAGAACTAAGGGATTTGTGACCCCAG
TGAAAAATCAACAACAATGTGGATCGTGTTGGTCATTCTCAACGACCGGT
TCCTTGGAAGGTCAACATTATCGAAAAACTCAAAATCTTATCAGCTTTTC
AGAACAACAGCTGGTTGATTGCAGTGGCTCTTTTGGAAATAACGGCTGCG
ATGGGGGGCTAATGGACAGTGCTTTCCAATACATCCAACAATACGGAATT
GAAGCCGAAAGTACATATCCTTACACCGCACAAGATGGAAATTGTGTATA
TGACAAATCAAAAGTTGTTGGAAGCTGCACTGGGTTCTCTGATATCCCCC
ACGGTAATGAGCAAGCATTGGCTTCAGCTGTTGCTACAGTTGGACCGATT
TCAGTGGCCATTGATGCCAGCAATTATAGTTTCCAATTATACAAGAGTGG
TATTTATAACGAACCTCAATGCTCTTCTTCCCAGTTAGATCACGGCGTCC
TCGCCATCGGCTATGGAACCGAAAACGGTAAGAATTTCTGGCTCGTCAAA
AATAGTTGGGGTATCGGATGGGGAATTCAAGGATACATCAAAATGAGCAA
AGACCAAGGAAACCAATGTGGAATATCTACAATGGCAAGCTATCCTTTGG
TCTAACTCATTTTGGATAAATGACATTATGCATAATGAAAAAATAAAATG
ATTTTTT
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protein sequence of SMED30018252-orf-1

>SMED30018252-orf-1 ID=SMED30018252-orf-1|Name=SMED30018252-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=333bp
MQIIILVSLFLAAVSAAPQQFTINSELNDEWEAYKTQFGKKYVSLNEISR
RLIWEQNLKYIQQHNLEHDLGKHTYTLGLNHFADMTNEEFRANYLGVSPK
RMNFTSHFIAPENVGALPSSVDWRTKGFVTPVKNQQQCGSCWSFSTTGSL
EGQHYRKTQNLISFSEQQLVDCSGSFGNNGCDGGLMDSAFQYIQQYGIEA
ESTYPYTAQDGNCVYDKSKVVGSCTGFSDIPHGNEQALASAVATVGPISV
AIDASNYSFQLYKSGIYNEPQCSSSQLDHGVLAIGYGTENGKNFWLVKNS
WGIGWGIQGYIKMSKDQGNQCGISTMASYPLV*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0000421tail
PLANA:0002142parenchyma
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR039417Peptidase_C1A_papain-like
IPR038765Papain-like_cys_pep_sf
IPR000668Peptidase_C1A_C
IPR013201Prot_inhib_I29
IPR025660Pept_his_AS
IPR025661Pept_asp_AS
IPR000169Pept_cys_AS
IPR007757MT-A70-like
Vocabulary: biological process
TermDefinition
GO:0006508proteolysis
GO:0006139nucleobase-containing compound metabolic process
Vocabulary: molecular function
TermDefinition
GO:0008234cysteine-type peptidase activity
GO:0008168methyltransferase activity
GO:0008233peptidase activity
GO:0016787hydrolase activity
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR000668Peptidase C1A, papain C-terminalPRINTSPR00705PAPAINcoord: 279..289
score: 56.26
coord: 135..150
score: 57.11
coord: 294..300
score: 64.62
IPR000668Peptidase C1A, papain C-terminalSMARTSM00645pept_c1coord: 117..331
e-value: 3.3E-121
score: 418.6
IPR000668Peptidase C1A, papain C-terminalPFAMPF00112Peptidase_C1coord: 117..330
e-value: 3.6E-83
score: 279.0
IPR013201Cathepsin propeptide inhibitor domain (I29)SMARTSM00848Inhibitor_I29_2coord: 31..90
e-value: 2.6E-28
score: 110.1
IPR013201Cathepsin propeptide inhibitor domain (I29)PFAMPF08246Inhibitor_I29coord: 31..90
e-value: 6.9E-16
score: 58.4
NoneNo IPR availableGENE3DG3DSA:3.90.70.10coord: 21..332
e-value: 4.5E-115
score: 386.5
NoneNo IPR availablePANTHERPTHR12411:SF631coord: 21..331
NoneNo IPR availablePANTHERPTHR12411CYSTEINE PROTEASE FAMILY C1-RELATEDcoord: 21..331
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..16
score: 0.881
IPR025660Cysteine peptidase, histidine active sitePROSITEPS00639THIOL_PROTEASE_HIScoord: 277..287
IPR025661Cysteine peptidase, asparagine active sitePROSITEPS00640THIOL_PROTEASE_ASNcoord: 294..313
IPR000169Cysteine peptidase, cysteine active sitePROSITEPS00139THIOL_PROTEASE_CYScoord: 135..146
IPR039417Papain-like cysteine endopeptidaseCDDcd02248Peptidase_C1Acoord: 118..330
e-value: 6.78107E-123
score: 349.615
IPR038765Papain-like cysteine peptidase superfamilySUPERFAMILYSSF54001Cysteine proteinasescoord: 22..331