Telomerase-binding protein EST1A
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30018250 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 5
Homology
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Match: SMG6 (SMG6 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:17809]) HSP 1 Score: 442.195 bits (1136), Expect = 2.047e-128 Identity = 301/917 (32.82%), Postives = 471/917 (51.36%), Query Frame = 3
Query: 1329 EMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXX-------XXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPS---IDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
E+QL ++ S D SP+ + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P+ + P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD+ARY E ++++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q RK KK T +EIWIHP + D + + S+ +L+K F LSFL++HGKLF +I ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL +R + E A+ + S + +W+DWM+ +P+ WNPPP+ D LPS +D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S GT E E D E +E E + I +L+ K+ L K E+ RR E + L DH R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE++F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK DFMP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 592 ELQLSNLL--SRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPN-VENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGK------------------DSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLD---LPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHS-QMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 1418
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Match: SMG6 (SMG6 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:17809]) HSP 1 Score: 263.462 bits (672), Expect = 1.225e-75 Identity = 186/568 (32.75%), Postives = 287/568 (50.53%), Query Frame = 3
Query: 2355 MENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPS---IDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL +R + E A+ + S + +W+DWM+ +P+ WNPPP+ D LPS +D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S GT E E D E +E E + I +L+ K+ L K E+ RR E + L DH R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE++F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK DFMP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 1 METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLD---LPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHS-QMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 510
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Match: SMG6 (SMG6 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:17809]) HSP 1 Score: 263.462 bits (672), Expect = 1.225e-75 Identity = 186/568 (32.75%), Postives = 287/568 (50.53%), Query Frame = 3
Query: 2355 MENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPS---IDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL +R + E A+ + S + +W+DWM+ +P+ WNPPP+ D LPS +D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S GT E E D E +E E + I +L+ K+ L K E+ RR E + L DH R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE++F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK DFMP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 1 METFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLD---LPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHS-QMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 510
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Match: SMG7 (SMG7 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:16792]) HSP 1 Score: 92.0485 bits (227), Expect = 8.040e-18 Identity = 58/216 (26.85%), Postives = 100/216 (46.30%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Match: SMG7 (SMG7 nonsense mediated mRNA decay factor [Source:HGNC Symbol;Acc:HGNC:16792]) HSP 1 Score: 92.4337 bits (228), Expect = 8.076e-18 Identity = 58/216 (26.85%), Postives = 100/216 (46.30%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 62 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 255
BLAST of Telomerase-binding protein EST1A vs. Ensembl Celegans
Match: smg-6 (Suppressor with Morphological effect on Genitalia [Source:UniProtKB/TrEMBL;Acc:Q1T6W7]) HSP 1 Score: 83.1889 bits (204), Expect = 1.758e-15 Identity = 56/197 (28.43%), Postives = 103/197 (52.28%), Query Frame = 3
Query: 3438 RKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLID----HKKFIIIVPLIVVNELENLSKTYQL--KDDVDIH-----ARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEW 3995
R+ ++D + + I P +L+ DTN I L +K L++ +KKF I+VP V++EL+ ++K L K + + H ++AK A+ +L+E+ + ++ +T+ G + T++ +E + E TNDD+ILN + P P + + + VL+TGDR L +KA+ + P + + F +W
Sbjct: 1045 REQMIDEQRGLGKTTIVIHPEYLIPDTNVLIGDLQLMKNLLETAQKNKKFQILVPTTVLDELQYIAKLSPLDSKSNSEAHDPERISKAKIAVAWLKEQAKQKTGHLYTLTTTGKRLPTLSIVSEDLEGHEMTTNDDMILNSALRWSESLPGSTAPSATE----ISQKCVLITGDRGLTIKAIGNNFPCRGISNFTKW 1237 HSP 2 Score: 77.0258 bits (188), Expect = 1.444e-13 Identity = 89/393 (22.65%), Postives = 150/393 (38.17%), Query Frame = 3
Query: 1413 ELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTG--HGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPET---------------GSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYA----------------------NRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMY 2474
EL ++Y VI D+ Y AG+EQ L++ FY +E +R N+ A P + + K+ + G + +N++ + E F TD + + S P E S T+K S + L+ LGDL RY +I+ S ++ ++ Y K+ L P G PYNQL ++ Y+ R +D + TR LA S+P+ A L + R T + + K+ R + +IWIHP T + D +++ + ++ +LH+ ++ G L KI M++F V +A LS S+ +L + +Y
Sbjct: 520 ELANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGSNS----AAPDARLIRAVTQKLLLNGIVYYENLIATYETQFHVALTDA---------LTWQSGSPSDEELCEQYIELPIGIQKFDSATQKTAIKSLSRHLISLGDLHRYKSLIDGSENYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARLVPVDVLSRQRQKRVIDEFFCLTRALACSHPYEVAKDRLKQRIDAMR-TKVAKYQPVLDKESGIVKEQGNVLRRLQRIRQIWIHP------------------ITETSQDGTGERIVDDVLVHFMEHSKAKLHRRAVSYLCDTFGMLVTKIGMDHFESVSERAFGLLYASLSKSETDFSADQLVKFSAMFIY 880
BLAST of Telomerase-binding protein EST1A vs. Ensembl Celegans
Match: smg-6 (Suppressor with Morphological effect on Genitalia [Source:UniProtKB/TrEMBL;Acc:Q1T6W7]) HSP 1 Score: 77.0258 bits (188), Expect = 1.431e-13 Identity = 89/393 (22.65%), Postives = 150/393 (38.17%), Query Frame = 3
Query: 1413 ELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTG--HGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPET---------------GSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYA----------------------NRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMY 2474
EL ++Y VI D+ Y AG+EQ L++ FY +E +R N+ A P + + K+ + G + +N++ + E F TD + + S P E S T+K S + L+ LGDL RY +I+ S ++ ++ Y K+ L P G PYNQL ++ Y+ R +D + TR LA S+P+ A L + R T + + K+ R + +IWIHP T + D +++ + ++ +LH+ ++ G L KI M++F V +A LS S+ +L + +Y
Sbjct: 363 ELANIYSQVIIHDVIYSFTAGLEQKLFRQAFYKCIESLRTGSNS----AAPDARLIRAVTQKLLLNGIVYYENLIATYETQFHVALTDA---------LTWQSGSPSDEELCEQYIELPIGIQKFDSATQKTAIKSLSRHLISLGDLHRYKSLIDGSENYEISKSCYQKSSQLWPSTGHPYNQLGIVVYYSMLYRSARRARLVPVDVLSRQRQKRVIDEFFCLTRALACSHPYEVAKDRLKQRIDAMR-TKVAKYQPVLDKESGIVKEQGNVLRRLQRIRQIWIHP------------------ITETSQDGTGERIVDDVLVHFMEHSKAKLHRRAVSYLCDTFGMLVTKIGMDHFESVSERAFGLLYASLSKSETDFSADQLVKFSAMFIY 723
BLAST of Telomerase-binding protein EST1A vs. Ensembl Celegans
Match: smg-7 (SMG-7; Suppressor with Morphological effect on Genitalia [Source:UniProtKB/TrEMBL;Acc:G5EF47]) HSP 1 Score: 62.7734 bits (151), Expect = 1.861e-9 Identity = 36/109 (33.03%), Postives = 66/109 (60.55%), Query Frame = 3
Query: 1704 IFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFE 2030
+F +R+P S+ V+++ +LL +GDL RY E ++ KA+ +Y ++ + P +G +NQL +IS ++L+++Y++TR L A+ FPTAS L+ +F+
Sbjct: 112 VFLNRKP---IKSKKNSRVFMAY--VLLRMGDLMRYKE------NYPKAQEYYEQSCRINPADGAVWNQLGLISSLGAKNLESVYFHTRALHATMEFPTASGGLTNIFK 209
BLAST of Telomerase-binding protein EST1A vs. Ensembl Fly
Match: Smg6 (gene:FBgn0039260 transcript:FBtr0084796) HSP 1 Score: 100.523 bits (249), Expect = 1.046e-20 Identity = 65/222 (29.28%), Postives = 106/222 (47.75%), Query Frame = 3
Query: 1386 WQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDE 2051
W++ + +L D ++ ++ L + + ++ WK +FY++ L + Q DQ H +L + K + + ++D SR + + AQ+LL+ LGDL RY ++D+ +A +Y +AQ LVP NG P+NQLAVISIY ++ DA+YYY R+L SN +A +SL LF+E R+ E
Sbjct: 190 WKNFCYIHDQLQDAFKQLLLEQLKFVCEHKVDVFFWKLLFYNVRNY------------LKRQQTDQ---------AHTHTLL---------LIEQAIKFYRM----LYDKLMAKCVASSRCDSALKVVAQRLLICLGDLTRYRVNHVKATDYMEAARYYQRAQELVPGNGAPFNQLAVISIYHHKRFDAVYYYVRSLLTSNSIQSAKESLLDLFDEIRRKYE 377 HSP 2 Score: 98.2117 bits (243), Expect = 5.771e-20 Identity = 68/193 (35.23%), Postives = 108/193 (55.96%), Query Frame = 3
Query: 3477 VELEIRPLFLVLDTNCYIDYLSNI-KLLIDHKKFIIIVPLIVVNELENLSKTYQL------KDDVDIH------ARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWA-DIRRS 4013
+ +E+RP +L+ DTNC+ID L + KL + K++ +I+PL VV EL+ LSK +L K IH +RAK++L+F++ A V+ T++G+F+ + A+ E +NDD IL + K + + D + ++VL+T DRNLR+KALSR++ V L F++WA D R S
Sbjct: 765 IYIEVRPRYLLPDTNCFIDCLEDFEKLSTEFKRYTLIIPLTVVKELDGLSKGVKLDSYRSSKQTQRIHHFDEVSSRAKKSLEFIKS----AKGNVKCATTKGSFVNASVF---ALVEEEYLSNDDKILATAMAVSKTAKTE---QCTDGKCFIQTELVLITTDRNLRVKALSRNLAVSALDEFLQWAKDCRES 947
BLAST of Telomerase-binding protein EST1A vs. Ensembl Zebrafish
Match: smg6 (SMG6 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-081107-52]) HSP 1 Score: 437.187 bits (1123), Expect = 3.846e-126 Identity = 302/929 (32.51%), Postives = 474/929 (51.02%), Query Frame = 3
Query: 1323 SLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEET-RKTDEM---MXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEI----------------FDEWAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTD-----DWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANL--KFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVD-------IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S E+QL ++ S + S + + + +R+EL+ +Y VI +D+++ + ++Q LWK+VFY ++E R + + ++ PQ IK + IL+ G +F S+ + + L+ D +T K +SAQ+ ++ GD+ARY E + S+++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEE RK D++ +++ + K T +EIWI P + + + T + D + + ++ +L+K F LSFL++HGKLF K+ ME+FP V + +L EF ALL H P PL S R+ I+ INM+ + + Q RS ++ A + L F LL QR E+ FDE + E + P DL LLP + +W+DWM+ HPE WNPPP + S D + ++ LC +R+ H VL +AD + + + LEE+ ++SGF+P+L +D +T + TD D + L F + LCG PLL + YI L I+ ++K + +D I + L + EID G+ + I +L+ +R L K +++ RR ++ +++L +E+E+RP +LV DTN +ID+L ++ L+ +I++VPLIV+ EL+ L+K ++ V + RA+ A+ FLE+ F+ D +RA+TSRG +E+IA+R+E S +G NDDVIL+CC H C+DK DFMP E++ P+ L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 707 SQELQLSNLL--SRERLSQEGLERMAQLRAELLTIYERVILTDIEFSDSQNVDQTLWKNVFYQVIERFRQLLKDQNSDTAPQ--------IKTMLM----TILEEGAVFFDSLLQKLQSVFQFKLQDYMDCMAIRARPLRKTVKYALISAQRCMICQGDIARYREQASESANYGKARSWYLKAQQIAPKNGRPYNQLALLAVYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKADQVERRLKQDSDGSAHGPKGHTGGRRGEDAARVEIWIRPSEVSGTSRPTGSESGK---------------DSEQDGELGALSASDLNKRFILSFLHAHGKLFTKVGMESFPAVANRVLLEFRALLQHSPSPLGSTRMLQIITINMFTI--YNAQIRAKGQGETRSALEEQAISLGLAMFGLLVQRCTELLKETPTEPIPAEELGEFDEMDDEEGMVR--VSVFPHDLRELLPSMKVWSDWMLGHPEKWNPPPCS----MQGSPDVWQCLADLCNSFSRVY----------HGEVLLYKADADGEGDEELRVLQLEEDKMLSGFVPLL------AAPQDACYTDQGTDAAIAADCKRVTVLKYFLEALCGQEEPLLAFK--GGKYISMAAP-----LTPSINTENKAQEQEDDVIVEESSLSAS-EGEIDGEMEGDGSEDD-------------------------IRELRARRHALAHKLAQQQKRRDKI--QAVLQ---TGGQLEIEVRPFYLVPDTNGFIDHLEGLRKLLACGTYILVVPLIVITELDGLAKGQDSREGVGNGAHARQVQDRARAAVMFLEKAFESRDPSIRALTSRGNTLESIAFRSEDTSGQKG-NNDDVILSCCLHYCQDKAKDFMPAERNGPVRLRREVVLLTDDRNLRVKALTRNVPVRDIPAFLIWAKV 1543
BLAST of Telomerase-binding protein EST1A vs. Ensembl Zebrafish
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-030131-9122]) HSP 1 Score: 90.1225 bits (222), Expect = 2.684e-17 Identity = 58/216 (26.85%), Postives = 100/216 (46.30%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + +++ K++ + + V + L++ ++ + ++ + N+DL S + G + K SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 32 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQS------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Zebrafish
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-030131-9122]) HSP 1 Score: 89.7373 bits (221), Expect = 2.739e-17 Identity = 58/216 (26.85%), Postives = 100/216 (46.30%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + +++ K++ + + V + L++ ++ + ++ + N+DL S + G + K SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 32 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQS------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Zebrafish
Match: smg5 (SMG5 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-050913-144]) HSP 1 Score: 71.633 bits (174), Expect = 9.657e-12 Identity = 54/224 (24.11%), Postives = 103/224 (45.98%), Query Frame = 3
Query: 1401 SVRSELMDL-YRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFD---------SRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRK 2042
S+R++L +L + + +DY +A E+ LW+ V+Y ++++I+ N+K S+ + I +G +F + I + ++L+ D R+ P S+ + ++ + L++LGDLARY + A +Y +A + P G P+NQL ++ +++A YYY R + + PF A +L LF++ K
Sbjct: 51 SLRNKLRELCVKLMFLHPVDYGRKA--EELLWRKVYYEVIQVIKT------------NKKHIHSRSALECAYRTHLI--AGVGFFQHLLLYIQSHYQLELQDCIDWTHVTDPLIGRKKPVSATSKEMEWAQMACHRCLVYLGDLARYQNELAGVEAEQLAERFYHQALSVAPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSETPFDGAYGNLKRLFDKASK 258
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:Xenbase;Acc:XB-GENE-1008562]) HSP 1 Score: 440.269 bits (1131), Expect = 2.396e-128 Identity = 313/1012 (30.93%), Postives = 503/1012 (49.70%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTI--NLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEET-RKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKE-DYV-SMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXXXX------------XXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVD---SCTYIP-TVIKE-GSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARA-----KEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G ++ + SN + PG P + P+ SPL T +M H + TL + + + + E+QL ++ S D S + + S+RSEL+ +Y + SD+++ +Q ++Q LWK+VFY ++E R F+ + + +I+ + +L G +F S+ + + LE D + + K +SAQ+ ++ GD+ARY E ++S++ KAR WYLKAQ + PKNGRPYNQLA+++IY R LDA+YYY R+LAASNP TA +SL LFEET RK D++ ++QQ+ TT EIWIHP + R+ E D + ++ +L+K F LSFL++ GKLF +I ME FP V +L+EF ALL H P P+ S R+ ++ INM+ ++ +A S+ Q+ A+ + L F+LL R I++ + + G + + +W+DWM+ HP+ WNPPP+ L P++D +G++++ C + + + P P ++ +L E+ L+SGF+P+L P+ + K D + L F + LCG PLL + S +P T+ KE GS +G +D+++V+IE+ + E + + + E L+ K+ L K E+ +R + +++LD + R ++LEI PLFLV DTN +I++L ++ L+ + +I+++PLIV++EL+ L+K + HARA ++A++FLE+ F+ D Y+RA+TSRG +++IA+R+E +S +G NDD+IL CC H CKDK +FM KD+PI L R+VVLLT DRNLR+KAL+RH+PV+ + F++WA +
Sbjct: 466 SDNPYYYPRSPFTYGGFSMPYSVGT-SNGMYPGAYYPGFPPQPGQFASGPYSGSPL--TPEEMEHQ-----VRTLQH-----QELNRMLRMADNQELQLSNLL--SRDGMSTEGLNRMASLRSELLQVYERCLLSDIEFSDQHNVDQLLWKNVFYQVIEKFRHFLKETSSDS---------EEIRRKLL----QVLDEGTAFFDSLLQKLQVTYQFKLEEYMDGMAIRSKPLRKMVKFALISAQRCMICQGDIARYREQAADTSNYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKADQLEQKQQKERGVSHTSDDTTRS-------EIWIHPI----------------------------RRGRESGECDALDALSPSDLNKRFLLSFLHAQGKLFTRIGMETFPLVAKKVLKEFQALLQHSPSPIGSTRMLQLMAINMFAVNNSQSKAGQAEGSC--SVVQEQATSLGLSMFSLLVCRCIQLLNVQKKAHCPRGKGQSMEEEEDDDIKVSSFIPDLKELLPSVKVWSDWMLGHPDTWNPPPNSLADLKEPALDVWGVLAEFCNALTSVNQSEVPLYKDPD--------------DDLSLLILEEDRLLSGFVPLL-AAPQEPCYVEKTSDKIIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTIGKETGSP---EGNQMEDQDDVVIEEYEEDSEPESSGAEHDFRE--------------------------------------LRAKKQELARKVEEQKRRQQKIQAVLDGKT--RLLQLEICPLFLVPDTNGFINHLPGLEHLLSCQIYILVIPLIVIHELDGLAKGQEFDQRNADHARALQEKARKAIQFLEQGFEARDPYLRALTSRGNELDSIAFRSEDISGQKG-NNDDLILCCCLHYCKDKAKEFMHSRKDEPIRLRREVVLLTDDRNLRVKALTRHVPVRDIPAFLKWAKV 1353
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:Xenbase;Acc:XB-GENE-1008562]) HSP 1 Score: 436.802 bits (1122), Expect = 8.362e-127 Identity = 315/1005 (31.34%), Postives = 505/1005 (50.25%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTI--NLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEET-RKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKE-DYV-SMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXX-----XXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVD---SCTYIP-TVIKE-GSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARA-----KEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G ++ + SN + PG P + P+ SPL T +M H L+ ++ + NQ E+QL ++ S D S + + S+RSEL+ +Y + SD+++ +Q ++Q LWK+VFY ++E R F+ + + +I+ + +L G +F S+ + + LE D + + K +SAQ+ ++ GD+ARY E ++S++ KAR WYLKAQ + PKNGRPYNQLA+++IY R LDA+YYY R+LAASNP TA +SL LFEET RK D++ ++QQ+ TT EIWIHP + R+ E D + ++ +L+K F LSFL++ GKLF +I ME FP V +L+EF ALL H P P+ S R+ ++ INM+ ++ + + S+ Q+ A+ + L F+LL R I++ + + + LLP + +W+DWM+ HP+ WNPPP+ L P++D +G++++ C + + + P P ++ +L E+ L+SGF+P+L P+ + K D + L F + LCG PLL + S +P T+ KE GS +G +D+++V+IE+ + E + + + E L+ K+ L K E+ +R + +++LD + R ++LEI PLFLV DTN +I++L ++ L+ + +I+++PLIV++EL+ L+K + HARA ++A++FLE+ F+ D Y+RA+TSRG +++IA+R+E +S +G NDD+IL CC H CKDK +FM KD+PI L R+VVLLT DRNLR+KAL+RH+PV+ + F++WA +
Sbjct: 511 SDNPYYYPRSPFTYGGFSMPYSVGT-SNGMYPGAYYPGFPPQPGQFASGPYSGSPL--TPEEMEHQVRTLQHQELNRMLRMAD------NQ----ELQLSNLL--SRDGMSTEGLNRMASLRSELLQVYERCLLSDIEFSDQHNVDQLLWKNVFYQVIEKFRHFLKETSSDS---------EEIRRKLL----QVLDEGTAFFDSLLQKLQVTYQFKLEEYMDGMAIRSKPLRKMVKFALISAQRCMICQGDIARYREQAADTSNYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKADQLEQKQQKERGVSHTSDDTTRS-------EIWIHPI----------------------------RRGRESGECDALDALSPSDLNKRFLLSFLHAQGKLFTRIGMETFPLVAKKVLKEFQALLQHSPSPIGSTRMLQLMAINMFAVNNSQSKGMMPEGSC--SVVQEQATSLGLSMFSLLVCRCIQLLNVQKKAHCPRGKEDDDIKVSSFIPDLKELLPSVKVWSDWMLGHPDTWNPPPNSLADLKEPALDVWGVLAEFCNALTSVNQSEVPLYKDPD--------------DDLSLLILEEDRLLSGFVPLL-AAPQEPCYVEKTSDKIIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTIGKETGSP---EGNQMEDQDDVVIEEYEEDSEPESSGAEHDFRE--------------------------------------LRAKKQELARKVEEQKRRQQKIQAVLDGKT--RLLQLEICPLFLVPDTNGFINHLPGLEHLLSCQIYILVIPLIVIHELDGLAKGQEFDQRNADHARALQEKARKAIQFLEQGFEARDPYLRALTSRGNELDSIAFRSEDISGQKG-NNDDLILCCCLHYCKDKAKEFMHSRKDEPIRLRREVVLLTDDRNLRVKALTRHVPVRDIPAFLKWAKV 1391
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Match: mgme1 (mitochondrial genome maintenance exonuclease 1 [Source:Xenbase;Acc:XB-GENE-1008562]) HSP 1 Score: 433.335 bits (1113), Expect = 1.290e-125 Identity = 315/1005 (31.34%), Postives = 505/1005 (50.25%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTI--NLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEET-RKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKE-DYV-SMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXX-----XXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVD---SCTYIP-TVIKE-GSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARA-----KEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G ++ + SN + PG P + P+ SPL T +M H L+ ++ + NQ E+QL ++ S D S + + S+RSEL+ +Y + SD+++ +Q ++Q LWK+VFY ++E R F+ + + +I+ + +L G +F S+ + + LE D + + K +SAQ+ ++ GD+ARY E ++S++ KAR WYLKAQ + PKNGRPYNQLA+++IY R LDA+YYY R+LAASNP TA +SL LFEET RK D++ ++QQ+ TT EIWIHP + R+ E D + ++ +L+K F LSFL++ GKLF +I ME FP V +L+EF ALL H P P+ S R+ ++ INM+ ++ + + S+ Q+ A+ + L F+LL R I++ + + + LLP + +W+DWM+ HP+ WNPPP+ P P++D +G++++ C + + + P P ++ +L E+ L+SGF+P+L P+ + K D + L F + LCG PLL + S +P T+ KE GS +G +D+++V+IE+ + E + + + E L+ K+ L K E+ +R + +++LD + R ++LEI PLFLV DTN +I++L ++ L+ + +I+++PLIV++EL+ L+K + HARA ++A++FLE+ F+ D Y+RA+TSRG +++IA+R+E +S +G NDD+IL CC H CKDK +FM KD+PI L R+VVLLT DRNLR+KAL+RH+PV+ + F++WA +
Sbjct: 511 SDNPYYYPRSPFTYGGFSMPYSVGT-SNGMYPGAYYPGFPPQPGQFASGPYSGSPL--TPEEMEHQVRTLQHQELNRMLRMAD------NQ----ELQLSNLL--SRDGMSTEGLNRMASLRSELLQVYERCLLSDIEFSDQHNVDQLLWKNVFYQVIEKFRHFLKETSSDS---------EEIRRKLL----QVLDEGTAFFDSLLQKLQVTYQFKLEEYMDGMAIRSKPLRKMVKFALISAQRCMICQGDIARYREQAADTSNYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKADQLEQKQQKERGVSHTSDDTTRS-------EIWIHPI----------------------------RRGRESGECDALDALSPSDLNKRFLLSFLHAQGKLFTRIGMETFPLVAKKVLKEFQALLQHSPSPIGSTRMLQLMAINMFAVNNSQSKGMMPEGSC--SVVQEQATSLGLSMFSLLVCRCIQLLNVQKKAHCPRGKEDDDIKVSSFIPDLKELLPSVKVWSDWMLGHPDTWNPPPNSLLPSQ-PALDVWGVLAEFCNALTSVNQSEVPLYKDPD--------------DDLSLLILEEDRLLSGFVPLL-AAPQEPCYVEKTSDKIIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTIGKETGSP---EGNQMEDQDDVVIEEYEEDSEPESSGAEHDFRE--------------------------------------LRAKKQELARKVEEQKRRQQKIQAVLDGKT--RLLQLEICPLFLVPDTNGFINHLPGLEHLLSCQIYILVIPLIVIHELDGLAKGQEFDQRNADHARALQEKARKAIQFLEQGFEARDPYLRALTSRGNELDSIAFRSEDISGQKG-NNDDLILCCCLHYCKDKAKEFMHSRKDEPIRLRREVVLLTDDRNLRVKALTRHVPVRDIPAFLKWAKV 1390
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:394870]) HSP 1 Score: 89.3521 bits (220), Expect = 6.184e-17 Identity = 56/213 (26.29%), Postives = 101/213 (47.42%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRR------PPPETGS----RTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + +G+ ++ Y+ Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRTNPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQMHSGTVVKPQSSSCAYI-CQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:394870]) HSP 1 Score: 88.9669 bits (219), Expect = 6.893e-17 Identity = 56/213 (26.29%), Postives = 101/213 (47.42%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRR------PPPETGS----RTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + +G+ ++ Y+ Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRTNPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQMHSGTVVKPQSSSCAYI-CQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Match: Smg6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2144117]) HSP 1 Score: 441.039 bits (1133), Expect = 2.842e-128 Identity = 314/1016 (30.91%), Postives = 500/1016 (49.21%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQ-----SNFITPGTINLMRAPPST--LTTP---HIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXX-------XXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G+ P+Q +N + PG PS + +P MSP H V L+ L + NQ E+QL ++ S D S + + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P++ P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD++RY E N+++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q RK KK T +EIWIHP + D + + S+ +L+K F LSFL++HGKLF +I ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL QR + + A+ + S + +W+DWM+ +P+ WNPPP+ D L ++D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S G E E D E +E E + I +L+ K+ L K + +R + +++L+ + R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE +F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK D+MP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 503 SDNPYYYPRTPGPASQYPYAGYSPLQYPVGPTNGMYPGAYYPGYPAPSGQYVCSPLPASTMSPEEIEQH--VRNMQQQELHRLLRVAD---------NQ----ELQLSNLL--SRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNS-ENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSAQGTESGK------------------DSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 1417
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Match: Smg6 (Smg-6 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2144117]) HSP 1 Score: 166.007 bits (419), Expect = 3.765e-44 Identity = 99/282 (35.11%), Postives = 159/282 (56.38%), Query Frame = 3
Query: 1329 EMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXX-------XXXXXXXXXXXXXXXGCIEIWIHP 2153
E+QL ++ S D S + + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P++ P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD++RY E N+++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q RK KK T +EIWIHP
Sbjct: 53 ELQLSNLL--SRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNS-ENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFRHVGDDTTRLEIWIHP 320
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Match: Smg7 (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2682334]) HSP 1 Score: 90.1225 bits (222), Expect = 2.713e-17 Identity = 57/216 (26.39%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + S Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 41 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 234
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Match: Smg7 (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2682334]) HSP 1 Score: 89.7373 bits (221), Expect = 2.887e-17 Identity = 57/216 (26.39%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLS-------------AQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + S Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Match: Smg7 (Smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans) [Source:MGI Symbol;Acc:MGI:2682334]) HSP 1 Score: 89.7373 bits (221), Expect = 3.069e-17 Identity = 57/216 (26.39%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLS-------------AQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + S Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Match: sp|Q86US8|EST1A_HUMAN (Telomerase-binding protein EST1A OS=Homo sapiens OX=9606 GN=SMG6 PE=1 SV=2) HSP 1 Score: 442.195 bits (1136), Expect = 9.828e-128 Identity = 301/917 (32.82%), Postives = 471/917 (51.36%), Query Frame = 3
Query: 1329 EMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXX-------XXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPS---IDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
E+QL ++ S D SP+ + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P+ + P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD+ARY E ++++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q RK KK T +EIWIHP + D + + S+ +L+K F LSFL++HGKLF +I ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL +R + E A+ + S + +W+DWM+ +P+ WNPPP+ D LPS +D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S GT E E D E +E E + I +L+ K+ L K E+ RR E + L DH R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE++F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK DFMP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 592 ELQLSNLL--SRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPN-VENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGK------------------DSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLD---LPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHS-QMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDFMPASKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 1418
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Match: sp|P61406|EST1A_MOUSE (Telomerase-binding protein EST1A OS=Mus musculus OX=10090 GN=Smg6 PE=1 SV=1) HSP 1 Score: 441.039 bits (1133), Expect = 1.988e-127 Identity = 314/1016 (30.91%), Postives = 500/1016 (49.21%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQ-----SNFITPGTINLMRAPPST--LTTP---HIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXX-------XXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G+ P+Q +N + PG PS + +P MSP H V L+ L + NQ E+QL ++ S D S + + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P++ P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD++RY E N+++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q RK KK T +EIWIHP + D + + S+ +L+K F LSFL++HGKLF +I ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL QR + + A+ + S + +W+DWM+ +P+ WNPPP+ D L ++D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + + V DT K E+ S G E E D E +E E + I +L+ K+ L K + +R + +++L+ + R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE +F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK D+MP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 503 SDNPYYYPRTPGPASQYPYAGYSPLQYPVGPTNGMYPGAYYPGYPAPSGQYVCSPLPASTMSPEEIEQH--VRNMQQQELHRLLRVAD---------NQ----ELQLSNLL--SRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNS-ENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSAQGTESGK------------------DSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVP-------------------------------DTMGK----EMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 1417
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Match: sp|Q5RAK6|EST1A_PONAB (Telomerase-binding protein EST1A OS=Pongo abelii OX=9601 GN=SMG6 PE=2 SV=1) HSP 1 Score: 440.654 bits (1132), Expect = 3.304e-127 Identity = 321/1016 (31.59%), Postives = 512/1016 (50.39%), Query Frame = 3
Query: 1050 SSNSTSYPTVPIMHGIQTISGFIPVQ-----SNFITPGTINLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIK-SLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXX-------XXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXX--------XXXXWTDWMVTHPEYWNPPPSHRDPLLLPS---IDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEEN-LISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S N YP P +G+ P+Q +N + PG PS P++ SPL ++ +P++ + + N+ + +H + ++ + E+QL ++ S D SP+ + + +R+EL+ LY I D+++ + ++Q LWK+ FY ++E R + +P+ + P+ ++++ ++ L G ++F S+ + + LE D + +T K +SAQ+ ++ GD+ARY E +++++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEET++ E M ++Q K KK T +EIWIHP + D + + S+ +L+K F LSFL++HGKLF +I ME FP V +L+EF LL H P P+ S R+ ++ INM+ + + Q + RS+ Q+ A+ + L F+LL R + E A+ + S + +W+DWM+ +P+ WNPPP+ D LPS +D + ++ C + + + P P ++ T ++LEE+ L+SGF+P+L P+ + K D + L F + LCG PLL + KD V + D+ + KE+ S GT E E D E +E E + I +L+ K+ L K E+ RR E + L DH R +ELEIRPLFLV DTN +ID+L+++ L++ +K+I++VPLIV+NEL+ L+K + +AR A+++++FLE++F+ D +RA+TSRG +E+IA+R+E ++ G NDD+IL+CC H CKDK DFMP K++PI L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 504 SDNPYYYPRTPGPASQYPYTGYNPLQYPVGPTNGVYPGPYYPGYPTPSG---PYVCSPLPASTM----SPEEVEQH-MRNLQQQE---LHRLLRVADNQELQLSNLL--SRDRISPEGLEKMAQLRAELLQLYERCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPN-VENPEQIRNRLLEL-----------LDEGSDFFDSLLQKLQVTYKFKLEDYIDGLAIRSKPLRKTVKYALISAQRCMICQGDIARYREQARDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFELSPDQWRKGKKSTFRHVGDDTTRLEIWIHPSHPRSSQGTESGK------------------DSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVH--NSQLKDCFSEECRSVIQEQAAALGLAMFSLLVCRCTYLLKESAKAQLSSPEDQDDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLD---LPSHVAVDVWSTLADFCNILTAVNQSEVPLYKDP---------------DDDLTLLILEEDRLLSGFVPLL-AAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAF-------------------------KDGKYVSVAPAPDT-------MGKEM---VSQEGTRLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHS-QMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSEDITGQLG-NNDDLILSCCLHYCKDKAKDFMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQV 1418
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Match: sp|Q92540|SMG7_HUMAN (Protein SMG7 OS=Homo sapiens OX=9606 GN=SMG7 PE=1 SV=2) HSP 1 Score: 92.0485 bits (227), Expect = 4.374e-17 Identity = 58/216 (26.85%), Postives = 100/216 (46.30%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Match: sp|Q5RJH6|SMG7_MOUSE (Protein SMG7 OS=Mus musculus OX=10090 GN=Smg7 PE=2 SV=1) HSP 1 Score: 89.7373 bits (221), Expect = 2.147e-16 Identity = 57/216 (26.39%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLS-------------AQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + ++ K++ + + V + L++ ++ + ++ + N+DL S + G + K + S Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQG------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQTHSSTIVKPQSSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 226
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Match: A0A4S2KZU3 (PINc domain-containing protein OS=Opisthorchis felineus OX=147828 GN=CRM22_010463 PE=4 SV=1) HSP 1 Score: 611.683 bits (1576), Expect = 0.000e+0 Identity = 418/1212 (34.49%), Postives = 607/1212 (50.08%), Query Frame = 3
Query: 858 VSLESDSHIHGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFS--QHVSSNSTSYPTVPIMH-----GIQTISGFIPVQSNFITPGTINLMR---APPSTLTTPHIMSPLRFTSHQMVHTPDDP-ALYTLSNIVSKS-------------PV------VVHCVNQIKSLEMQLDVMI-------RSSCDISSP------------------DWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQK----DQVSKIKMSVTGHGQNI-----LQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCI---EIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKE----------------------DYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVN------------------------NYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHY---------------RVLSDSKEADKAI-------NNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEI--AQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKK-FIIIVPLIVVNELENLSK------TYQLKDDVD--------IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSW-SEGETNDDVILNCCQHLCKDKPVDFMPRE----------KDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
S ++D+ HGGLIHLP++++I +S + N + KP V+VRP+FS Q S + T T+ H GI P QS+ T +++ ++ + + M L + H DD +L + + SK PV + + QI L+ L ++ R+ + P WW +V +R L L+ SVI DLD+CN A +EQ +WKSVFY+ +EL+R++I++P++ L + + +Q + + +T Q+I + SGE ++ I +H + L + RPPPET SRTR+LVYLSAQKL+LFLGDLARY E++N +F KAR WY +AQLL+PKNGR YNQLAV+++Y +RHLDA+YYY RTLAASNPF TASQSLS LF E R E + RQ K + EIW+HP DG + + + QKV ++ E +Y +M LIEL + F L+F+++HGKL+ KI ME FPEV S LQ F LL+ +PCPLS+ RLC + I+NMY +DR + N LRS+H DHA+R LDFF+LLC+R ++ E + + LP D LLL L LW++WM+ HPE+W PPP+HRDP L P ++D+ LI+ LCT+ + R RP Y RV E D + N + L EE + +GF PMLD +PK+Y WT E D++ +EK+ LFGDFLCGI+ P+L Y+VD Y + +E SER + D + + E + E + +K T EAS + I L+ +RA L+ + E+ R WR + + +R VELE+ P++L+ DTNCYID+L I L + ++VP++VVNEL+ L++ +++ DD + I RA+ A+ +LE +F + +RA+T+RG+FMETIA+R E + G+ NDDVIL CC H CK+ P F R ++P+ +HR++VLLT DRNLRLKAL+ ++PV+PL+ F+ W+ +
Sbjct: 165 TSAKTDTTKHGGLIHLPKDIDIYQSSDEPKAGISRQPKRGN----QGGTTKPVVVVRPSFSKVQRYSESETLGSTLAADHHGDTKGIGHDGVGFP-QSSRTTSASVSALQNTWTDTAKAAYQYYMQALSQMDQERQHPFDDANSLSNVGTVNSKQGAQRSATSSNFAMPVQAPNEKISAVIQQIVQLDAALTALLIPPGICARALPCVEPPPAHPQPGKQWTEPQLLILRWWSTVERLRERLFTLFESVILFDLDFCNTAHVEQGMWKSVFYTALELMRSWISHPESTNLVRTDRKVEDEQSVEEREQITSLLQHICLSDVIASGETRLSNLLDRIQTIHRVRLAPLIADGRPPPETRSRTRRLVYLSAQKLMLFLGDLARYKELLNGERNFGKARSWYQRAQLLIPKNGRSYNQLAVLAVYTSRHLDAMYYYMRTLAASNPFATASQSLSALFNEIRPRAENLIRQLRKPKNEPNAPHHGPFGNPNNRFQRAEIWVHPIDGQTTVLQGARRLVYLPPPTNAS---TQKVSTKLGEMDLDTNCDNEDDDDEDAQAELEEYANMSLIELSRQFGLTFIHAHGKLYTKIGMETFPEVASLALQAFSGLLAQKPCPLSAERLCQLCIVNMYNVDRAVSLTNASNLSTIKRTESDSKTPKIQPISHLAGVETLRSVHHDHAARFALDFFSLLCRRTAQLLQEPVPQDAPA----WWLPPDARLLLSALRLWSEWMILHPEHWLPPPNHRDPTLRPCLNDWQLIASLCTQAANWMNRNP---LRPRYEELTPTTSMVLQSKDRVEGQDLEEDTSAEAHAYLGGNFENAFLFEEAVCAGFKPMLDLVPKMYTY-SGHWTAETVADFVRVEKIVLFGDFLCGIDSPVLSYDVDRGAYEAVIEREMSERKE---DKQTDPSISDERRVSESESVGFSGEKPPVPYEPVEETEYEASGD---------------------IVALQRQRALLQRQLEEESRLAAWRWNAIRQAASGGRRAVELEVHPIYLLPDTNCYIDWLEGIATLAQRSSNYTVLVPIVVVNELDTLARYGSSSNSWRTADDEEGDVTRAGLIQERARAAITYLEHEFAHRNTRLRALTARGSFMETIAFRNEINGGRAPGQVNDDVILACCNHFCKEDPERFSSRRGNDQGFVGESNNQPMRIHREIVLLTSDRNLRLKALNINVPVRPLRTFVNWSRL 1336
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Match: G4VE87 (PINc domain-containing protein OS=Schistosoma mansoni OX=6183 GN=Smp_131650 PE=4 SV=1) HSP 1 Score: 601.668 bits (1550), Expect = 0.000e+0 Identity = 428/1258 (34.02%), Postives = 636/1258 (50.56%), Query Frame = 3
Query: 825 NSNTEIKDKAIVSLESDSHIHGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFSQ---HVSSNSTSYPTVPIMHGI---QTISGFIPVQSNFITPGTI---NLMRAPPSTLTTP-----------HIMSPLRFTSHQMV---------HTPDDPALYTLSNIVSKSP--VVVHCVNQIKSLEMQLDVMI----------------RSSCDI----SSPD-----WWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIAL-PQNQKDQ-------------VSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDE---MMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMP-------------------------LIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDR---VSQQASVVNNY-------------------------------------ALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTK----VNRL-----VERGTPALS---RPHYRVLSDSK---EADKAI---------NNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEI--AQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDH-KKFIIIVPLIVVNELENLSK---TYQLKDDVD----------------IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSW-SEGETNDDVILNCCQHLCKDKPVDFMPR-------------EKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
NS + A ++ E+ + HGGLI LP++++I Q + + V S S KP V+VRP+FS H + ST + HG+ + I+ N ++P +P + L P + +F+S + H + P T + +++ P ++ + QI L+ L ++ +S ++ + P+ WW +V +R L L+ SVI +DLD+CN A +EQ +WKSVFY+++E +R++I NP + L P+ K++ + KI +S ++ G S+ I +H+I L + RPPPET SRTR+LVYLSAQKL+LFLGDLARY E + +F KAR WY KAQLLVPKNGR YNQLAV+++Y +RHLDA++YY RTLAASNPF TASQSL+ LF E R + M ++ ++ + ++ N + EIWIHP DG D+ + I++ S P LIEL K F L+F+++HGKL+ KI ME FPEV S LQ LL+ +PCPLS+ RLC + ++NM+ +DR ++ Q + +NN ALRS+H DHA+R LD F+L+C+RA ++ E + SN G + A + L L WT+WM+ HPE+W PPP+HRDP L P +DD+ L++KLCT+ + RL E TP S R + D K ++DK+ N K L EE ++GF PMLD PKIY D W E D++ +EKL LFGD+LCGI P+L+YN+D Y + +E SERLQD D N I ++ SD +L+ + K++++ ++ + +S++ T ++ IA L+ +RA L+ + ++ R + WR++ + QR VE+E+RP++L+ DTNCYID+L I L + ++VP++VVNEL+ LS+ + VD I RAK A+ +LE +F+ + +RA+T+RG+ METIAYR E + G+TNDDVIL CCQH CK+ F R + ++P+ L R+VVLLT DRNLRLKAL+ +IP +PL+ F+ W+ +
Sbjct: 141 NSRSLTNTCANLTSENSTEKHGGLILLPKDVDI-----FQQNTQNSRSFRREAVRSDSS--KPVVVVRPSFSNPYNHPRTTSTRSDS----HGVDESKYINQCKQKSDNDMSPRCFVSDASTESPTTVLPVPWTDAAKAAFYQFFKTQTKFSSSPSLQAERPSSTHHFANQPTCLTPGSAITQPPNEMIASAMQQIVQLDATLSALLIPPGLCAQSMVLFEPLQSDPELGREWTEPEALFLRWWGTVKRLRDSLFLLFESVIVADLDFCNTAHVEQGMWKSVFYTVLESLRSWIENPQSTQLIPKVDKNEETTKLLQSQLVNLIQKICIS------EVIDFGSNQLASLLERIQSIHHIQLGPLLSDGRPPPETKSRTRRLVYLSAQKLMLFLGDLARYRETLVGERNFGKARNWYQKAQLLVPKNGRSYNQLAVLALYTSRHLDAMFYYMRTLAASNPFATASQSLAALFNEIRPRAQNMIMQFQKPKTESVQPHCSGFSSYNPRFQRAEIWIHPIDGQTTVIQGGRRLMHSNIKPTI-DESNNIQGKSIQKLNSSTPELEVDNEDEDDEEAQAEAEEYANISLIELSKQFGLAFIHAHGKLYTKIGMETFPEVASLTLQALSGLLAQKPCPLSTERLCQLFVVNMFNVDRAASMTNQTNTMNNSVKNRISESKINVNNDNKIPLNIGMDNFVPSSRLTEIEALRSVHHDHAARFALDTFSLVCRRAAQLLQETPPMD--SNPGWISPDARILLSALCL--WTEWMILHPEHWLPPPNHRDPTLRPHLDDWLLVAKLCTEAASWLTRLSVKPNYEEITPTTSLVLRLKGELNCDEKLDDDSDKSSTLYHIFEDGNLYKATFLSEEAFVAGFKPMLDLTPKIYYYTGD-WDPETVADFVRIEKLVLFGDYLCGIETPVLNYNIDQAVYESVIQRESSERLQD--KRVDVNANIKQN--SSDINLENEEKRQLELMSVLNDNKNLSSDDGTIESNSVLTD----------IAALQRQRAFLQKQLDEEARLDAWRRNAIRQAASGGQRAVEIEVRPIYLLPDTNCYIDWLEGIATLAQKSSNYTVLVPIVVVNELDTLSRFGSSSSGGGGVDRPYEAAVGGEVTRAGLIQERAKLAINYLEYQFEHRNSRLRALTARGSLMETIAYRNEINGGRTPGQTNDDVILTCCQHFCKEDSDRFQLRNLTEGVDLSMQGGQNNQPMRLVREVVLLTSDRNLRLKALNVNIPARPLRTFVNWSRL 1361
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Match: A0A504YEK1 (Telomerase binding protein EST1A OS=Fasciola gigantica OX=46835 GN=FGIG_08273 PE=4 SV=1) HSP 1 Score: 595.119 bits (1533), Expect = 0.000e+0 Identity = 369/1021 (36.14%), Postives = 540/1021 (52.89%), Query Frame = 3
Query: 1383 WWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQ----------NQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXX---GCIEIWIHPXXXXXXXXXXX---------------------XXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKL---FTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRV-------------------SQQASVVNNY---------------------------ALRSLHQDHASRMTLDFFALLCQRAIEIFDE---------WAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRP-------------------HYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEI--AQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKK-FIIIVPLIVVNELENLSK---------TYQ----LKDDVD------IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSE-GETNDDVILNCCQHLCKDKP-------------VDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
WW +V+ +R L L+ SVI SDLDYCN A +EQ +WKSVFY+++EL+R++I+NP++ + Q N+++ V + + +++++ GE+ S+ + +++I L + RPPPET SRTR+LVYLSAQKL+LFLGDLARY E++ +F KAR WY KAQLLVPKNGR YNQLAV+++Y +RHLDA+ YY RTLAASNPFPTASQSL+ LF E R E + RQ K + + + +EIWIHP DG + ND+ + + +E+Y +M LIE KL F L F+ +HGKL+ KI ME FPEV S LQ F LL+ +PCPLS+ RLC + ++NMY +DR S+ + + + LRS+H DHA+R LD F+LLC+R + E W + L+L ++WM+ HPE+W PPP+HRDP L P ++D+ L+++LCT+ + R + +RP Y V K++ ++ + L EE ++GF PMLD IPK+Y D WT E D++ +EKL LFGDFLCGI PP+L Y++D Y + +E SE+ QD + N + + DS++ + K E +S NT+ + Q S AD IA L++KRA L+ + E+ R WR++ + +R VELE+RP++L+ DTNCYID+L I L + ++VP++VVNEL+ L++ T++ +++D + I RA A+ +LE +F + +RA+T+RG+F+ETIAYR E E G+TNDDVIL CC H CKD +F + ++P+ + R+VVLLT DRNLRLKA + ++P +PL+ F+ W+ +
Sbjct: 51 WWTAVHRLRERLFSLFESVILSDLDYCNTAHVEQGMWKSVFYTVLELLRSWISNPESTGMLQVDPHSSSGNSNEENDVLFVLRHICL--KDVIEVGEDRLCSLLDRVQSINHIYLAPLLADGRPPPETRSRTRRLVYLSAQKLMLFLGDLARYREILLGDRNFGKARNWYQKAQLLVPKNGRSYNQLAVLAMYTSRHLDAMCYYMRTLAASNPFPTASQSLAALFNEIRPRAENLMRQLRRPKAEVTNSHHASFHSADPRFQRVEIWIHPLDGQTTVLQGARRLVYLPTPTTCSSQKNISRPSQSSSDWDRVGENDEDDEDAQAE-QEEYANMSLIEASKLSRQFGLMFIYAHGKLYTKIGMETFPEVASMALQAFSGLLAQKPCPLSAERLCQLCVVNMYNVDRAMSLTTHVGSISSTMEKQSGSKASGAFDRFDRPHYSGSKSEMDRSEIQPISRLSGSETLRSVHHDHAARFALDAFSLLCRRTAHLLQEPIPDGEPTWWIPPDARLLLSALRLW-------------SEWMILHPEHWLPPPNHRDPTLRPYLNDWKLVAELCTRAANWLNRNS---TRPEYEEANPTTSLVLCLKGLSEYEVEDGEKQSRDLVHEFQAAFLFEEAYVAGFKPMLDLIPKLYRYTGD-WTAETVADFVRIEKLVLFGDFLCGIEPPVLTYDLDRAIYESAIERESSEKKQD----RPSNSLPLNYSRDSNDSTSSPNDKSKPETSS---HNTDLKDSQAS-AD---------------IAALQLKRALLQHQLEEEARLAAWRRNAISQAASGGRRAVELEVRPIYLLPDTNCYIDWLEGIATLAQRSSNYTVLVPIVVVNELDILARFGSSSSNGSTWRSGRLVEEDSEVTRAGLIQERAHRAITYLEHEFAVRNTRLRALTARGSFLETIAYRTEINGGREPGQTNDDVILACCNHFCKDDSDRLCLGGFGRNADQEFPGEQTNQPMRIVREVVLLTSDRNLRLKATNINVPARPLRTFVNWSRL 1028
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Match: A0A419PZW2 (COP9 signalosome complex subunit 5 OS=Clonorchis sinensis OX=79923 GN=CSN5 PE=4 SV=1) HSP 1 Score: 592.808 bits (1527), Expect = 1.472e-177 Identity = 363/985 (36.85%), Postives = 516/985 (52.39%), Query Frame = 3
Query: 1383 WWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQK----DQVSKIKMSVTGHGQNI-----LQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCI---EIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKE----------------------DYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVN------------------------NYALRSLHQDHASRMTLDFFALLCQRAIEIFDE---------WAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHY---------------RVLSDSKEADKAI-------NNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEI--NSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEI--AQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKK-FIIIVPLIVVNELENLSK------TYQLKDDVD--------IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSW-SEGETNDDVILNCCQHLCKDKPVDFMPRE----------KDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLK 3980
WW +V +R L L+ S+I DLD+CN A +EQ +WKSVFY+ +EL+R++I++P++ L + + +Q + + +T Q+I + SGE ++ I +H + L + RPPPET SRTR+LVYLSAQKL+LFLGDLARY E++N +F KAR WY +AQLL+PKNGR YNQLAV+++Y +RHLDA+YYY RTLAASNPF TASQSLS LF E R E + RQ K + + EIW+HP DG + +T QKV + E +Y +M LIEL + F L+F+++HGKL+ KI ME FPEV S LQ F LL+ +PCPLS+ RLC + I+NMY +DR + N LRS+H DHA+R LDFF+LLC+R ++ E W ++ L+L ++WM+ HPE+W PPP+HRDP L P ++D+ LI+ LCT+ + R RP Y RV E D + N + L EE + +GF PMLD +PK+Y WT E D++ +EK+ LFGDFLCGI+ P+L Y+VD Y + +E SER +D + + I D E E + T EAS + I L+ +RA L+ + E+ R WR++ + +R VELE+ P++L+ DTNCYID+L I L + ++VP++VVNEL+ L++ +++ DD + I RA+ A+ +LE +F + +RA+T+RG+FMETIA+R E + G+ NDDVIL CC H CK+ P F R ++P+ +HR++VLLT DRNLRLKAL+ ++PV+PL+
Sbjct: 237 WWSTVERLRERLFTLFESIILFDLDFCNTAHVEQGMWKSVFYTALELMRSWISHPESTNLVRTDRKVEDEQSVEEREQITSLLQHICLSDVIASGETRLSNLLDRIQTIHRVRLAPLLADGRPPPETRSRTRRLVYLSAQKLMLFLGDLARYKELLNGERNFGKARSWYQRAQLLIPKNGRSYNQLAVLAVYTSRHLDAMYYYMRTLAASNPFATASQSLSALFNEIRPRAENLIRQLRKPKNEPNAPHHGPFSNPNNRFQRAEIWVHPIDGQTTVLQGARRLVYLPPPTNTG---TQKVSTKPGEVDLDTNCDNEDDDDEDAQAELEEYANMSLIELSRQFGLTFIHAHGKLYTKIGMETFPEVASLALQAFSGLLAQKPCPLSAERLCQLCIVNMYNVDRAVSLTNTSNLSTIKRTESDSKTPKIQPISHLAGVETLRSVHHDHAARFALDFFSLLCRRTAQLLQEPVPQDAPAWWLPSDARLLLSALRLW-------------SEWMILHPEHWLPPPNHRDPTLRPCLNDWQLIASLCTQAANWMNRNP---LRPRYEELTPTTSMVLQSKDRVEGQDLEEDTSAEAHTYLGGNFENAFLFEEAVCAGFKPMLDLVPKMYTY-SGHWTAETVADFVRVEKIVLFGDFLCGIDSPVLSYDVDRGAYEAVIEREMSERKED-----KQTDPSISDERRVSESGSVGFGDEKPSVPYEPVEETEHEASGD---------------------IVALQRQRALLQRQLEEESRLAAWRRNAIRQAASGGRRAVELEVHPIYLLPDTNCYIDWLEGIATLAQRSSNYTVLVPIVVVNELDTLARYGSSSNSWRTADDEEGDVTRAGLIQERARAAITYLEHEFAHRNTRLRALTARGSFMETIAFRNEINGGRAPGQVNDDVILACCNHFCKEDPERFSSRRGNDQGYVGESNNQPMRIHREIVLLTSDRNLRLKALNINVPVRPLR 1175
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Match: A0A068YBR0 (Telomerase binding protein EST1A OS=Echinococcus multilocularis OX=6211 GN=EmuJ_000831300 PE=4 SV=1) HSP 1 Score: 585.104 bits (1507), Expect = 5.356e-177 Identity = 408/1213 (33.64%), Postives = 606/1213 (49.96%), Query Frame = 3
Query: 885 HGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFSQHVSSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTINLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSK--SPVVVHCVNQIKSLEMQLDVMI----------------RSSCDISSPD-------WWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPD-TIALPQNQKDQVSK----------IKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEET---------RKTDEMMXXXXXXXXXXXXXXXXXXXXXXXG---CIEIWIHPXXXXXXXXXXXXXXXXXXXXXXX------------------------NDDPKQKVDRQI-KEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVS---QQASV-------------------------------VNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRL---------VERGTPALS-------RPHY-RVLSDSKEADKAINNK-----KTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKN--EVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQ--RFVELEIRPLFLVLDTNCYIDYLSNI-KLLIDHKKFIIIVPLIVVNELENL------------------------SKTYQLKDDVD-----IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSE-GETNDDVILNCCQHLCKDKPVDF--------MPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADIR 4007
HGGLIHLP+N+ I S + N A D + S SN + + S+ +PG + A P+ T+ + LR Q+ P+ L+ + SK SP V V QI ++ L+ ++ +S + P+ WW ++ ++RS LM Y VI DLD+CN A IEQ +WKSVFY+++E +R +I NP T LP+ ++ + + IK+ +++++ GE + + + +I L+ + RPPPE+GSRT +L+Y+SAQKL+L+LGDLARY E+IN +F KAR WY KAQLL+PK+G+PYNQLA+++IY +RH DA+ YY R+LAASNPFPTASQSLS LF E +K+ S + + +G +EIWIHP +GT+ + A T +D+ ++ + Q E+Y +M LIEL KLF L F+++HG+LF KI ME FPEV S LQ LL+ +PCPLS RLC IL++NM+ +DR + Q++V V + LRS+H DHA+R LD F+L+C+RA ++F E+ S L DL +LLP L LWT+WM+ HPE+W+PPP+HRDP L P +DD+ L++++CT + V+ TP + R H D +A + N+ K L EE + +GF PMLD IPK+Y D W E +I +EK+ LFGDFLCGI PP+L Y+VD Y P V E + G K + + E P SD + + +++ + T+ ++ EE E + I L+ +RA L+ + + RR E WR+ + A R +E+E+RP++++ DTNCYID+L + +L + ++VP++V NEL+NL S + + I RAK A+ FLE +F++ + +RA+T++G+ +ETIAYR EA + G+ NDDVIL CC+ CK+ K++P+ + R+VVLLT DRNLRLKALS +IP +PL+ F+EW+ ++
Sbjct: 132 HGGLIHLPKNVNIFNQSSPNGGNL-GSAQRDACLKS--------------------SNKSG------------------IHSSRESPGEGTTVGALPTISTS----AGLRGKDLQLFEQPNGAYSSVLAQLSSKPSSPTVAEAVYQIMQIDSALNALLVPPGQCISHIPPLPDEQSENKLQMPESERLFLRWWATLENLRSSLMVNYERVILEDLDFCNAAQIEQGMWKSVFYTVLEFLRPWIANPYLTGLLPKPEESESGQAVAAAACSRMIKLIRKVCLEDVIRIGEHRLTGLLNRLQAIRHIHLDYVLSEGRPPPESGSRTCRLMYISAQKLMLYLGDLARYEEIINGGQNFGKARSWYQKAQLLIPKSGKPYNQLALLAIYTSRHFDAMCYYMRSLAASNPFPTASQSLSALFNEVHTHGAEFLRKKSTSSQWPPGYSSSQTGLSSNRASNIFTRGRPKRVEIWIHPVNGTETIVQGNRSLTVPNAAARTEAWRKSKKIVGTANSLSLPSDELLDDENEEGEEAQADAEEYANMSLIELTKLFGLHFMHAHGQLFTKIGMETFPEVASMALQALSGLLAQRPCPLSEDRLCQILMVNMFNLDRAAIFTAQSAVGMVAAIGRSKIGAAEVSRRQQQQQLLQRKPKVESETLRSVHHDHAARFALDTFSLICRRAAKLF---TESRAESRTSGDWLHPDLRILLPALRLWTEWMILHPEHWSPPPNHRDPTLHPRLDDWRLVAEMCTHAAQWFAGVKSAPSVKEITPTTALVVQLHLRKHMAEADGDHPDATAELVNRIPAFLKYTTLFEETVCAGFKPMLDLIPKMYQYSGD-WDAESVAHYIRIEKILLFGDFLCGIEPPVLSYDVDKAIYEPVV---ECESFEQGPIKKSASCYQSDSESPTGSDAESEVEVQSGGKSV--------------TAALKAEKEEGIEENEGGEEICALRRRRAVLRSQLTEARRLEAWRQQAVRQAAAGGPRGIEIEVRPIYILPDTNCYIDWLEGVARLTQTSSNYTVLVPIVVFNELDNLASQDRAFAFNSIEIAFAQYLTNPSSTSSEFNGSSGGRANLIQERAKAAIAFLEGEFNRRNPRLRALTAKGSMLETIAYRNEANGGKQPGQINDDVILTCCRRFCKEVLAQISAEGNLVSTAESKNQPMRVTREVVLLTSDRNLRLKALSLNIPARPLRPFVEWSSLK 1280
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Match: smg6 (SMG6 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-081107-52]) HSP 1 Score: 429.483 bits (1103), Expect = 7.787e-125 Identity = 298/936 (31.84%), Postives = 470/936 (50.21%), Query Frame = 3
Query: 1254 ALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXX---XXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEW-AETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDS--CTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANL--KFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDI------HAR-----AKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
A+ T V +V + S E+QL ++ S + SP+ + +R+EL+ LY VI +D+++ + ++Q LWK+VFY ++E R + + D+ PQ + M +T IL+ G +F ++ + + LE D +T K +SAQ+ ++ GD+ARY E ++S+++ KAR WYLKAQ + PKNGRPYNQLA++++Y R LDA+YYY R+LAASNP TA +SL LFEE ++ E + R+++ + EIWI P + + N+ K D + S+ +L+K F LSFL++HGKLF K+ ME+FP V +LQEF ALL H P PL S R+ I+ INM+ + + + RS+ ++ + + L F LL QR ++ E AE E++ ADL LLP + +W+DWM+ HPE WNPPP DP D + +++LC + R+ P Y+ D E D+ + + +++GF+P+L P+ D + D + L F + LCG PLL + +P V + E DKNE + H N E + + + I +L+ +R L + +++ RR ++ +++L +ELEIRP +LV DTN +ID+L ++ L+ ++++VPLIV+ EL+ L+K + +D + HA+ AK A+ FLE+ F+ + +RA+TSRG +E+IA+R+E S +G NDD+IL+CC H C+DK DFMP ++ P+ L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 531 AIATEEAEVQTRGELVKMLRLADSQELQLSNLL--SRERLSPEGLDRMAQLRAELLTLYERVILTDIEFSDSQNLDQALWKNVFYQVIERFRQLLKDQDSDTAPQLRA-------MLLT-----ILEEGAMFFDTLLQKLQTIFQFKLEDYMDGMAIRARPLRKTVKYALISAQRCMICQGDIARYREQASDSANYGKARSWYLKAQQIAPKNGRPYNQLALLAVYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKAEQIERRRKQDSEGSVCGPRGRGWSRGEDATRQEIWIRP-----------SGHPGVPSRTAGNESSK---DSEQDGGLSSLNASDLNKRFILSFLHTHGKLFTKVGMESFPAVAGRVLQEFRALLQHSPSPLGSTRMLQIMTINMFTIHYAQTRET-------RSVLEEQTTSLGLAMFGLLVQRCTDLLKETPAEEESMVR--VSAFSADLRELLPSVKVWSDWMLGHPEQWNPPPYSVDP------DVWQCLAELCNALARVHHSEIPL-----YKADGDG-EGDEELRLLVLEE---DGMLAGFVPLL-AAPQEPCYIDPQTDTAMASDCKRVTVLKYFLEALCGQEEPLLAFKGGKYISVAVPPVPSQQVE---------DKNE------------------------SQVHEQNQEVEGDGS----------------EDDIKELRARRHALTHELAQQQKRRDKI--QAVLQ---TGGQLELEIRPFYLVPDTNGFIDHLEGLRKLLACGSYVLVVPLIVITELDGLAKGQESRDGDCVGVGGAAHAKMVQECAKAAVTFLEKGFEAREPGLRALTSRGNQLESIAFRSEDTSGQKG-NNDDLILSCCLHYCQDKAKDFMPANREGPVRLRREVVLLTDDRNLRVKALTRNVPVRDIPAFLSWAKV 1358
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:103037658]) HSP 1 Score: 89.7373 bits (221), Expect = 2.952e-17 Identity = 59/216 (27.31%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + +L K++ + + V + L++ ++ + ++ + N+DL S + G + K SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 32 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQI------------TSLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:103037658]) HSP 1 Score: 89.3521 bits (220), Expect = 3.013e-17 Identity = 59/216 (27.31%), Postives = 99/216 (45.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSA-------------QKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + +L K++ + + V + L++ ++ + ++ + N+DL S + G + K SA Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 32 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQI------------TSLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQSSTSAIVKPQPSSCSYICQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:103037658]) HSP 1 Score: 75.8702 bits (185), Expect = 4.374e-13 Identity = 53/203 (26.11%), Postives = 91/203 (44.83%), Query Frame = 3
Query: 1407 RSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
R L DLY+ ++ +DL+Y +EQ+LW F + + +L K++ + + V + L++ ++ + ++ + N+DL S + G + K SA + I F +A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 33 RQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQI------------TSLQSQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSS----QLGIISNKQSSTSA-----IVKPQPSSCSYICQCVCFLQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 214
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Match: smg5 (SMG5 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:103035711]) HSP 1 Score: 67.781 bits (164), Expect = 1.130e-10 Identity = 52/224 (23.21%), Postives = 102/224 (45.54%), Query Frame = 3
Query: 1401 SVRSELMDL-YRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFD---------SRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRK 2042
S+R++L +L + + +DY +A E+ LW+ V+Y ++++I+ N+K S+ + I +G ++ + I + ++L+ D R+ P + + ++ + L++LGDLARY + A +Y +A + P G P+NQL ++ +++A YYY R + + PF A +L LF++ K
Sbjct: 51 SLRNKLRELCVKLMFLHPVDYGRKA--EELLWRKVYYEVIQVIKT------------NKKHIHSRSALECAYRTHLI--AGVGFYQHLLLYIQSHYQLELQDCIDWTHVTDPLIGRKKPVSATPKEMEWAQMACHRCLVYLGDLARYQNELAGVEAEQLAERFYHQALSVSPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSETPFEGAYGNLKRLFDKAAK 258
BLAST of Telomerase-binding protein EST1A vs. Ensembl Sea Lamprey
Match: smg5 (SMG5 nonsense mediated mRNA decay factor [Source:ZFIN;Acc:ZDB-GENE-050913-144]) HSP 1 Score: 64.3142 bits (155), Expect = 3.113e-10 Identity = 55/248 (22.18%), Postives = 109/248 (43.95%), Query Frame = 3
Query: 1335 QLDVMIRSS--C-DISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFD---------SRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRK 2042
+LD +I SS C ++ P+ N +R + L + +DY +A E+ LW+ V+Y ++ ++A N+K ++ M L +G ++ + + + ++L+ D + + P SR + ++ L++LGDLARY + + +YL+A + P G P NQL ++ + +++A YYY R + + F A ++ +F + +K
Sbjct: 27 RLDTIISSSSVCQEVFKPENVSQRNKLRELCVQL---MFLHPVDYGRKA--EELLWRKVYYEVIHAVKA------------NRKQLQTRGSMECAYRTH--LVAGVGFYQHLLLTLQSHYQLELQACIDWTHVVDTLSAVKKPAVVSSRALEWARMACHHCLIYLGDLARYQNELGVIDTHHLSERFYLQALAVAPHVGMPLNQLGTLAGNRSYNVEAAYYYMRCIQSEVGFDGAVGNMRRVFIKAKK 255
BLAST of Telomerase-binding protein EST1A vs. Ensembl Nematostella
Match: EDO34379 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SPJ8]) HSP 1 Score: 104.76 bits (260), Expect = 7.203e-23 Identity = 65/219 (29.68%), Postives = 106/219 (48.40%), Query Frame = 3
Query: 1416 LMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDL---------------EVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLF 2027
L DLY+ ++ +DL+ IEQ+LW S F S ++ +R Q +D+ K V L++ ++I + ++ +++DL +V S+RP ++ Y Q L+ LGD+ARY + D T+A ++Y A +LVP NG+PYNQLA+++ HL +Y+Y R++A N FP AS +L F
Sbjct: 27 LQDLYKRILLNDLELALDKKIEQDLWNSAFKSQIDFLR------------QKARDKKCTSKNEVQAVLTLFLETASGFYIQLLQELCMTYDLDLPGHARSSHLGLLDDGDVNSSSKRPHTQS-------CYYVCQDCLVHLGDIARYCD------DATQAEVFYRHALVLVPSNGQPYNQLAILASARGDHLGTVYFYCRSIAVKNQFPAASTNLHKTF 220
BLAST of Telomerase-binding protein EST1A vs. Ensembl Nematostella
Match: EDO42311 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7S1W9]) HSP 1 Score: 65.4698 bits (158), Expect = 2.189e-11 Identity = 46/189 (24.34%), Postives = 80/189 (42.33%), Query Frame = 3
Query: 1479 EQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGS----RTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEE 2033
E+ LW+ VFY +++ +R Q +VS + ++ L S Y+ + + L+ +L+ + T S + Q+ LL++GDLARY + A +Y +A L P+ G P+NQL + + + + +Y+Y R L A F +L LFE+
Sbjct: 56 EELLWRKVFYDVIQWLR--------------QHRKVSPNDEHLESSCRSHLISASGYYYHLLIQLQSLYGTNLKGVVSWTAQGLHTASGIDAEVADWALRACQRCLLYMGDLARYQQEFEGEKSIKLAERFYCEALHLNPQLGMPHNQLGTLLVSQSCGAEGVYHYLRCLIAKESFEGTEGNLVRLFEK 230
BLAST of Telomerase-binding protein EST1A vs. Ensembl Nematostella
Match: EDO31223 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SYI2]) HSP 1 Score: 51.6026 bits (122), Expect = 3.826e-6 Identity = 46/168 (27.38%), Postives = 80/168 (47.62%), Query Frame = 3
Query: 3498 LFLVLDTNCYIDYLSNIKLLIDH-----KKFIIIVPLIVVNELENL-SKTYQLK-----------DDVDIHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKAL 3950
L+++LDTN + +L I L D + ++IVP IV+ EL++L S +++ + + A+A++A++FL F+ +R +T+A E VS E+NDD IL+CC + F + + + VL + D+NL KA+
Sbjct: 570 LYIILDTNILLSHLKFITELKDFPIEGVGRPVLIVPWIVMQELDSLKSDSWKFRKGKIINAENKESQRGVDAQARQAVRFLHSCFEANHPRIRG--------QTLAESLEHVSDLPEESNDDRILHCC--------LMFQMKASNG------NAVLFSNDQNLCSKAM 715
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Match: smg6 (SMG6 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:101166408]) HSP 1 Score: 410.223 bits (1053), Expect = 9.481e-117 Identity = 301/941 (31.99%), Postives = 459/941 (48.78%), Query Frame = 3
Query: 1329 EMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXX---XXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEW-AETETISNNGXXXXXXXXXXXXXXXXX--------------WTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLD--QIPKIYLLEDDKWTKEQ-TDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVI----KEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFK-EEKNRRFELWRKSLLDHEIAQRFVELE--IRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSK--------------------TYQLKDDVD-IHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADI 4004
E+QL ++ S D S D + +R++L+ LY VI +D+++ + ++Q LWK+VFY ++E R + +P P + M +T +L G ++F ++ + ++ LE D +T K +SAQ+ ++ GD+ARY E +S+++ KAR WYLKAQ + PKNGRPYNQLA+++IY R LDA+YYY R+LAASNP TA +SL LFEE ++ E + +++ + ++ + +EIWI P+ T D + + S+ +L K F LSFL++HGKLF K+ ME+FP V S ++QEF LL H L S + I+ INM+ V S RS+ Q+ ++ + L FALL QR E+ E AE+ +++ + + + W+DWM+ HP WNPPP D S D + ++ LC V V+ L Y+V SD E D+ + L E+ L++GF+P+L Q P Y+ DK T E D + L F + LCG PLL + + T E + QD + ++ +VI+E ++ L ++E D H N I QLK + L K ++ +R + + L Q +LE IRPLFLV DTN +ID+L +K ++ +II+VPLIV+ EL+ L+K Y V + +A+ A+ FLE+ F+ + +RA+TSRG +E+IA+R+E S +G NDDVIL+CC H CKDK DFMP +K+ + L R+VVLLT DRNLR+KAL+R++PV+ + F+ WA +
Sbjct: 783 EVQLSNLL--SRDRVSADGLDRMAQLRADLLGLYEQVILTDIEFSDSQNVDQALWKNVFYQVIERFRQLLKDPSYDNTPHIRN-------MLLT-----LLDEGAQFFDALLQKVQTVYQFTLEDYMDGMAIRARPLRKTVKYALISAQRCMICQGDIARYREQATDSANYGKARSWYLKAQQIAPKNGRPYNQLALLAIYTKRKLDAVYYYMRSLAASNPILTAKESLMSLFEEAKRKAEQLEQRRRQENEGGSQGPAVRGRRKDEESSRVEIWIRPNGQTATPFNKRGGSESSR-------------DSEQDGELGSLSATDLKKRFILSFLHAHGKLFTKVGMESFPGVASRVIQEFKTLLQHGASLLGSTNILQIITINMFA---VHNSQSKGEEGETRSVLQEQSTALGLGMFALLVQRCTELLKEIPAESIQVADGEEEEEKTGEPEGMVRVSAFPLDLRELLPGIKVWSDWMLGHPHQWNPPPCGID----CSPDVWQYLANLCN-VLAHVDHEEVLL----YKVDSDEGENDEELT---VLQLKEDKLLAGFVPLLAAPQEP-CYI---DKHTDEAIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYISVATSASNNQSEDARNRQDSLTENEQADVILE----AESSLSASEEEEEDFDGGGHSGND--------------------------IRQLKARHHALTNKLAQRQKRLDKIQAVL------QPGGQLELEIRPLFLVPDTNGFIDHLEGLKKVLHCGSYIIVVPLIVITELDGLAKGQDTFGGGLGSRGRSTGSRGNYNSAAHVRAVQDKARLAVAFLEKGFEAREPCLRALTSRGNQLESIAFRSEDTSGQQG-NNDDVILSCCLHYCKDKAKDFMPPQKNGTVRLQREVVLLTDDRNLRVKALTRNVPVRDIPSFLSWAKV 1640
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:101155720]) HSP 1 Score: 88.5817 bits (218), Expect = 5.413e-17 Identity = 59/223 (26.46%), Postives = 103/223 (46.19%), Query Frame = 3
Query: 1395 VNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRR----------------PPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
V + R L DLY+ ++ +DL+Y +EQ+LW F + + +++ K++ + + V + L++ ++ + ++ + N+DL S + P P + S Y+ Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 28 VWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQS------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVRSSQLGIISNKQGSGGAIVTPQPSSCS------YI-CQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:101155720]) HSP 1 Score: 88.5817 bits (218), Expect = 6.081e-17 Identity = 59/223 (26.46%), Postives = 103/223 (46.19%), Query Frame = 3
Query: 1395 VNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRR----------------PPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
V + R L DLY+ ++ +DL+Y +EQ+LW F + + +++ K++ + + V + L++ ++ + ++ + N+DL S + P P + S Y+ Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 28 VWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQS------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVRSSQLGIISNKQGSGGAIVTPQPSSCS------YI-CQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Match: smg7 (SMG7 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:101155720]) HSP 1 Score: 88.1965 bits (217), Expect = 6.510e-17 Identity = 59/223 (26.46%), Postives = 103/223 (46.19%), Query Frame = 3
Query: 1395 VNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRR----------------PPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSL 2015
V + R L DLY+ ++ +DL+Y +EQ+LW F + + +++ K++ + + V + L++ ++ + ++ + N+DL S + P P + S Y+ Q L+ LGD+ARY ++A +Y A LVP NG+PYNQLA+++ HL ++YY R++A PFP AS +L
Sbjct: 28 VWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQS------------QAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVRSSQLGIISNKQGSGGAIVTPQPSSCS------YI-CQHCLVHLGDIARYRNQT------SQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNL 225
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Match: smg5 (SMG5 nonsense mediated mRNA decay factor [Source:NCBI gene;Acc:101173007]) HSP 1 Score: 69.3218 bits (168), Expect = 4.277e-11 Identity = 51/224 (22.77%), Postives = 103/224 (45.98%), Query Frame = 3
Query: 1401 SVRSELMDL-YRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFD---------SRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRK 2042
S+R++L +L + + +DY +A E+ LW+ V+Y ++++I+ N+K S+ + I +G ++ + + + ++L+ D R+ P + + ++ + L++LGDLARY + A +Y +A ++P G P+NQL ++ +++A YYY R + + PF A +L LF++ K
Sbjct: 51 SLRNKLRELCVKLMFLHPVDYGRKA--EELLWRKVYYEVIQVIKT------------NKKHVHSRSALECAYRTHLI--AGVGFYQHLLLYVQSHYQLELQDCIDWTHVTDPLIGRKKPVSASPKEMEWAQMACHRCLVYLGDLARYQNELAGVETEQLAERFYHQALSVMPHVGMPFNQLGTLAGSKFYNVEATYYYLRCIQSDAPFEGAYGNLKRLFDKAAK 258 HSP 2 Score: 55.0694 bits (131), Expect = 9.270e-7 Identity = 40/137 (29.20%), Postives = 64/137 (46.72%), Query Frame = 3
Query: 3375 LKIKRANLKFKEEKNRRFELWRK----------SLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARAKEALKFLEEKFDKADQYVRAITSRGTFME 3755
L+ +A + EE+ RR L R S L+ + Q + + P +LV DT +LS I+ L FIII+P V++ L+ L K +A A++ ++FLE +F K ++Y+R G E
Sbjct: 898 LQQAKAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSSMSP-YLVPDTAALCQHLSLIRQLAGSGCFIIIIPRAVIDGLDALKKE---------NAGARDGIRFLESEFRKGNRYIRCQKESGRSFE 1024
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Match: SMESG000051442.1 (SMESG000051442.1) HSP 1 Score: 2404.79 bits (6231), Expect = 0.000e+0 Identity = 1313/1315 (99.85%), Postives = 1313/1315 (99.85%), Query Frame = 3
Query: 81 MASKKNKKPDQEIYRPPKSDRSNYDVNDKSHERTFYNSNHKKKVIKSDVEEKIKKPEGQTKIASRDGKSNPYYYEGDTSXXXXXXXXXXXXXXXXXXXXXXXKDDYEYESYNDKKRYSSAHYVDDNYYQSYDSRYYKTVDYNXXXXXXXXXXXXXXXXERPYKSPDERPRQKVQTNYXXXXXXXXXXXXXXXXXXXENYEDKKPVNYEYNQNVRSRQNSYNKDFTDTRLFNPYKTESDIMSGKSVKPSNSNTEIKDKAIVSLESDSHIHGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFSQHVSSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTINLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMXXXXXXXXXXXXXXXXXXXXXXXGCIEIWIHPXXXXXXXXXXXXXXXXXXXXXXXNDDPKQKVDRQIKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGXXXXXXXXXXXXXXXXXWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTXXXXXXXXXHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADIRRSFRRK 4025
MASKKNKKPDQEIYRPPKSDRSNYDVNDKSHERTFYNSNHKKKVIKSDVEEKIKKPEGQTKIASRDGKSNPYYYEGDTSGNYYNEDYGYYKYDSYSPRYPKYKDDYEYESYNDKKRYSSAHYVDDNYYQSYDSRYYKTVDYNSFKPQSKFKSYQSYSYERPYKSPDERPRQKVQTNYQKKPDKQQKVKKETKPNKPENYEDKKPVNYEYNQNVRSRQNSYNKDFTDTRLFNPYKTESDIMSGKSVKPSNSNTEIKDK IVSLESDSHIHGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFSQHVSSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTINLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMRRQQESIKRKKKKQTTTTENRKKGCIEIWIHPDDGTKEKKVTDDDDADILATFDTNDDPKQKVDRQ KEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGPLQLPADLSLLLPPLCLWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTEQAEEEEREHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADIRRSFRRK
Sbjct: 1 MASKKNKKPDQEIYRPPKSDRSNYDVNDKSHERTFYNSNHKKKVIKSDVEEKIKKPEGQTKIASRDGKSNPYYYEGDTSGNYYNEDYGYYKYDSYSPRYPKYKDDYEYESYNDKKRYSSAHYVDDNYYQSYDSRYYKTVDYNSFKPQSKFKSYQSYSYERPYKSPDERPRQKVQTNYQKKPDKQQKVKKETKPNKPENYEDKKPVNYEYNQNVRSRQNSYNKDFTDTRLFNPYKTESDIMSGKSVKPSNSNTEIKDKPIVSLESDSHIHGGLIHLPENLEIKKSGSVSQINSPAVAASDNVVTSKISDNKPTVMVRPTFSQHVSSNSTSYPTVPIMHGIQTISGFIPVQSNFITPGTINLMRAPPSTLTTPHIMSPLRFTSHQMVHTPDDPALYTLSNIVSKSPVVVHCVNQIKSLEMQLDVMIRSSCDISSPDWWQSVNSVRSELMDLYRSVITSDLDYCNQAGIEQNLWKSVFYSIMELIRAFINNPDTIALPQNQKDQVSKIKMSVTGHGQNILQSGEEYFISIFTDISKLHNIDLEVIFDSRRPPPETGSRTRKLVYLSAQKLLLFLGDLARYSEMINNSSDFTKARIWYLKAQLLVPKNGRPYNQLAVISIYANRHLDALYYYTRTLAASNPFPTASQSLSFLFEETRKTDEMMRRQQESIKRKKKKQTTTTENRKKGCIEIWIHPDDGTKEKKVTDDDDADILATFDTNDDPKQKVDRQFKEDYVSMPLIELHKLFTLSFLNSHGKLFGKINMENFPEVCSTMLQEFWALLSHQPCPLSSYRLCNILIINMYIMDRVSQQASVVNNYALRSLHQDHASRMTLDFFALLCQRAIEIFDEWAETETISNNGPLQLPADLSLLLPPLCLWTDWMVTHPEYWNPPPSHRDPLLLPSIDDFGLISKLCTKVNRLVERGTPALSRPHYRVLSDSKEADKAINNKKTFVLLEENLISGFLPMLDQIPKIYLLEDDKWTKEQTDDWIHLEKLSLFGDFLCGINPPLLDYNVDSCTYIPTVIKEGSERLQDGIDAKDKNEVIIEDPIDSDEDLDTKLKKEIDEINSTHGTNTEASNEQTSWADLTEQAEEEEREHQKRIAQLKIKRANLKFKEEKNRRFELWRKSLLDHEIAQRFVELEIRPLFLVLDTNCYIDYLSNIKLLIDHKKFIIIVPLIVVNELENLSKTYQLKDDVDIHARAKEALKFLEEKFDKADQYVRAITSRGTFMETIAYRAEAVSWSEGETNDDVILNCCQHLCKDKPVDFMPREKDKPITLHRDVVLLTGDRNLRLKALSRHIPVKPLKRFMEWADIRRSFRRK 1315
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Match: SMESG000035043.1 (SMESG000035043.1) HSP 1 Score: 182.57 bits (462), Expect = 2.322e-46 Identity = 85/91 (93.41%), Postives = 87/91 (95.60%), Query Frame = -3
Query: 5091 MAREKYNDVILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHVGEFAYQIMMLAERAFGDRARWNEATLALVKDQFWAGLS 5363
MAREKYNDVILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHV EFAYQIMMLA+RAFGDRA WNEATL LVKDQFWA +S
Sbjct: 1 MAREKYNDVILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHVREFAYQIMMLAKRAFGDRALWNEATLTLVKDQFWAAVS 91
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Match: SMESG000018010.1 (SMESG000018010.1) HSP 1 Score: 130.183 bits (326), Expect = 8.161e-31 Identity = 73/185 (39.46%), Postives = 107/185 (57.84%), Query Frame = -3
Query: 4962 IPVKPYNGNPGEFPEFMSEYFQMARALGLSEPVMILRLPLYLKGMAREKYNDVILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHVGEFAYQIMMLAERAFGDRARWNEATLA---LVKDQFWAGLSSAMRNALSLHIGDNFEELTRKAVLIESSI----EKVNNFAVSANKSD 5495
+PV Y G+ EF +FM EY+ A A G ++PVM+ RLPLYLK A+E + N W++L+ L N+++ GD RI+RQ+FYNR Q S E V EFA+ + LA++AF + + L++DQF G +R AL +NF+EL +KA+ IE ++ +K +FAV K D
Sbjct: 35 LPVNQYRGDAVEFTDFMGEYYMYATAYGWTQPVMVQRLPLYLKRTAQEAGQQLDKRNIGNDWSKLKDELANKLISGDIKRIMRQKFYNRVQRSEESVSEFAHYLTTLADKAFEVKQEQPDTVKQIRELLQDQFLMGADKEIRKALCYVDFNNFDELVKKAMQIELNLKNTEKKAQSFAVIYKKRD 219
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Match: SMESG000080881.1 (SMESG000080881.1) HSP 1 Score: 130.183 bits (326), Expect = 1.409e-29 Identity = 72/191 (37.70%), Postives = 111/191 (58.12%), Query Frame = -3
Query: 4962 DFLRYPTIPVKPYNGNPGEFPEFMSEYFQMARALGLSEPVMILRLPLYLKGMAREKYNDV---ILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHVGEFAYQIMMLAERAFG---DRARWNEATLALVKDQFWAGLSSAMRNALSLHIGDNFEELTRKAVLIESSIEKVNNFAVSANKSD 5516
D+ +PV+ Y G+P EF +F ++Y+ A A G S+ +M+ RLPLYLKG ARE + + ++AN W +L+ AL +++ GD RI+RQ+FYNR Q E V EFAY + LAE+AF ++ + L++DQF G+ ++ AL +NF+EL +KA+ IE +++ A S D
Sbjct: 1565 DYASCQKLPVQQYGGDPVEFVDFKADYYMYATAYGWSQSIMVQRLPLYLKGAAREAWQQIDKRLIAND---WTKLKDALAAKLIGGDIKRIMRQKFYNRVQRPDESVSEFAYHLTTLAEKAFEIKPEQVDVVKQVKELLQDQFLTGVRKEIKKALCYVDFNNFDELIKKAMKIELNLKTTQPKAESFTTID 1752
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Match: SMESG000057446.1 (SMESG000057446.1) HSP 1 Score: 123.25 bits (308), Expect = 1.764e-27 Identity = 82/275 (29.82%), Postives = 132/275 (48.00%), Query Frame = -3
Query: 4851 DFLRYPTIPVKPYNGNPGEFPEFMSEYFQMARALGLSEPVMILRLPLYLKGMAREKYNDV---ILANHPVAWNELRVALTNRILPGDATRILRQQFYNRRQNSGEHVGEFAYQIMMLAERAFG---DRARWNEATLALVKDQFWAGLSSAMRNALSLHIGDNFEELTRKAVLIE-------------SSIEKVNNFAVSANKSD--------------------------------IECFNCHKRGHLSKDCTSKRSN--SPGDKLCTRCGRNNH 5516
D+ +PV+ Y G+P +F +FM++Y+ A A G S+ +M+ RL L LKG ARE + + +AN W +L+ AL +++ GD RI+RQ+FYNR Q E V EFAY + LA++AF ++ + L++DQF G+ ++ AL +NF+EL +K + IE ++I++ + +VS K++ ++C +C K GH C K ++ SP C C R H
Sbjct: 34 DYASCQKLPVQQYGGDPVKFVDFMADYYMYATAYGWSQSIMVQRLRLNLKGAAREAWQQIDKRFIAND---WTKLKDALAAKLIGGDIKRIMRQKFYNRVQRPDESVSEFAYHLTTLAKKAFEIKPEQVDVAKQMKELLQDQFLTGVRKEIKKALCYVDFNNFDELIKKTMKIELNLKTTQPKAESFTTIDESRDRSVSPIKNNLFQKSTSPSPKFRVKFEPRKSTCSPNEERERPVQCSHCQKLGHNINQCWFKNNSGRSPSPVQCDHCQRKGH 305 The following BLAST results are available for this feature:
BLAST of Telomerase-binding protein EST1A vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 3
BLAST of Telomerase-binding protein EST1A vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 1
BLAST of Telomerase-binding protein EST1A vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 4
BLAST of Telomerase-binding protein EST1A vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 1
BLAST of Telomerase-binding protein EST1A vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of Telomerase-binding protein EST1A vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 3
BLAST of Telomerase-binding protein EST1A vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of Telomerase-binding protein EST1A vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30018250 ID=SMED30018250|Name=Telomerase-binding protein EST1A|organism=Schmidtea mediterranea sexual|type=transcript|length=5941bpback to top protein sequence of SMED30018250-orf-1 >SMED30018250-orf-1 ID=SMED30018250-orf-1|Name=SMED30018250-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1316bp MASKKNKKPDQEIYRPPKSDRSNYDVNDKSHERTFYNSNHKKKVIKSDVEback to top protein sequence of SMED30018250-orf-2 >SMED30018250-orf-2 ID=SMED30018250-orf-2|Name=SMED30018250-orf-2|organism=Schmidtea mediterranea sexual|type=polypeptide|length=334bp MSEYFQMARALGLSEPVMILRLPLYLKGMAREKYNDVILANHPVAWNELRback to top Annotated Terms
The following terms have been associated with this transcript:
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