neurexin-1 isoform X16
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Overview
Neoblast Clusters
Zeng et. al., 2018▻ Overview▻ Neoblast Population▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Overview
Single cell RNA-seq of pluripotent neoblasts and its early progeniesWe isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)Explore this single cell expression dataset with our NB Cluster Shiny App
Neoblast Population
Sub-lethal Irradiated Surviving X1 and X2 Cell Population
Embryonic Expression
Davies et. al., 2017
Hover the mouse over a column in the graph to view average RPKM values per sample. Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult. back to top Anatomical Expression
PAGE et. al., 2020SMED30018208 has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGEPAGE Curations: 10
Homology
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Match: NRXN1 (neurexin 1 [Source:HGNC Symbol;Acc:HGNC:8008]) HSP 1 Score: 329.331 bits (843), Expect = 1.691e-91 Identity = 347/1542 (22.50%), Postives = 608/1542 (39.43%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSE--------------------EEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE + P +Q + I+VA +CP ++ E + G+ P A + +P+ P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECP--SDDEDIDPCEPSSGGLANPTRAGGR---------------------EPY----------------------PGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1439 HSP 2 Score: 53.1434 bits (126), Expect = 4.963e-6 Identity = 61/242 (25.21%), Postives = 94/242 (38.84%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T F +V+ K V V + + F + +GG + + + R + F+G I VN+S + L ++ E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QVLPVDSGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Match: NRXN1 (neurexin 1 [Source:HGNC Symbol;Acc:HGNC:8008]) HSP 1 Score: 329.717 bits (844), Expect = 1.805e-91 Identity = 349/1543 (22.62%), Postives = 608/1543 (39.40%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS--------------------IMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1457 HSP 2 Score: 53.5286 bits (127), Expect = 4.131e-6 Identity = 57/240 (23.75%), Postives = 93/240 (38.75%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKE----NYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T F +V+ K V V + + F + +GG + + + R + F+G I VN+S +L + + +D+ P++ C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS----------QVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Match: NRXN1 (neurexin 1 [Source:HGNC Symbol;Acc:HGNC:8008]) HSP 1 Score: 328.176 bits (840), Expect = 4.789e-91 Identity = 351/1544 (22.73%), Postives = 607/1544 (39.31%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEF-ASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + AS E + P + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1458 HSP 2 Score: 53.5286 bits (127), Expect = 4.309e-6 Identity = 61/242 (25.21%), Postives = 94/242 (38.84%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T F +V+ K V V + + F + +GG + + + R + F+G I VN+S + L ++ E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QVLPVDSGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Match: NRXN1 (neurexin 1 [Source:HGNC Symbol;Acc:HGNC:8008]) HSP 1 Score: 327.405 bits (838), Expect = 9.721e-91 Identity = 349/1547 (22.56%), Postives = 609/1547 (39.37%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1461 HSP 2 Score: 53.5286 bits (127), Expect = 4.769e-6 Identity = 61/242 (25.21%), Postives = 94/242 (38.84%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T F +V+ K V V + + F + +GG + + + R + F+G I VN+S + L ++ E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QVLPVDSGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Match: NRXN1 (neurexin 1 [Source:HGNC Symbol;Acc:HGNC:8008]) HSP 1 Score: 321.242 bits (822), Expect = 8.560e-89 Identity = 350/1555 (22.51%), Postives = 611/1555 (39.29%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS--------------------IMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1469 HSP 2 Score: 53.5286 bits (127), Expect = 4.694e-6 Identity = 57/240 (23.75%), Postives = 93/240 (38.75%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKE----NYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T F +V+ K V V + + F + +GG + + + R + F+G I VN+S +L + + +D+ P++ C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLFIDQVEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS----------QVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Match: nrx-1 (NeuReXin related [Source:UniProtKB/TrEMBL;Acc:I2HAJ7]) HSP 1 Score: 235.343 bits (599), Expect = 3.732e-62 Identity = 266/1132 (23.50%), Postives = 478/1132 (42.23%), Query Frame = 2
Query: 701 CYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEIN---RSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSI-YKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQ-----FRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPV-SFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTID--DSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAK-KLSPLNIELTASLQPA---NVMRQFA-INFHSTKSYLVIPKVNI---FGDFRLEFQMKTLQPSGLLLFL--QGESNDYLILEMVNGLLHIIYNWGSGYK-----RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDY-------GFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSS----EVSSK------------NSFQGFISGLTINEIAILDTLKENFNSYILLI 3934
C F + R C K + LTF + +GY +++ + + ++ FKT S LFY G + ++ V ++DG II S+ + R F NS + DD WH + ++ + + +D + E + + + + F + +P++ P + FRGCMK++ + + +V + + S K DI C V SFT S YL S+ S F+T SD LI Y + H TD+ + E+ D L+ I L S V ++ VS+G H++ L +++D + ++ + ++IG++ + ++ S VWS L ++GCI ++ ++ + I + ++ I GC S E L++C PC N G C + CDC+ TNF G C E E NG + +T S+VE+ + F++ G++ T +G DK+ +F+ + + + L N F ++ D+ WH ++++R + L +++D ++ + +L+ I ++ +G+AF +H ++ F G++ ++NG +Y LAK K++ + ++S + NV + A I+F ++ Y+ I G FR++F+ +TL S LL F + + + L+M+NG L Y SG + K+ L+D WH+V I + KTH VD + S + + GK++ G S R GF+GCI++ +N + DL ++A+ + V+ C + C D+C+ G+C Q W CDCS T+ SG +C++ STT +F PS + Y+Y+ ++ + ++ F F T TQ L++IE DY G++ Y H+ + DG H+++ + T+++D L + P +++ + +G++ + K +S+QG ISG+ +N + ILD L EN ++ I I
Sbjct: 253 CQFSDHDGRNCEIEKNDGE---LTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYAGD-----------EKSYLHVMLQDGA--IIASSKFDGSDARIIRMF--NSFPSQRYDDDSWHTIILERSLQMMTLIVDGRRDEIRQYAPELDWISNSFGFLGS-----------IPKHNPSKEVNRVSFRGCMKKVRYDIDATRILLVNLADQSYGG--SVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQ---HNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSS-VWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNE---LDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGVLFDTGA--NGKNDKITVFLNDSQLNLFLQDSSTNNTFSWGKSLSDNHWHELQVRRLGQKLLLYLD-GFWSHSIYLQNP---ISVEIDEVGAAFS-----------------VH-SSAPPPRDEHFKGFLSKLVFNGNDY--LAKTKMNSAQLSKSSSRESKGQRNVKTRIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYR-TSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQD-EKTHDHVLLVD---NSSTTLIIDKIKKVESKMSGKLYFGSNPLGVS---------RPSNGFRGCISTLRINENA--------LDLYEDADSRMKVNRGC----SGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRT-----------TQPNGVLISIECAADQDYFTIFLNKGYLNAHYNLGNRDHTTSYHTRILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMILD-LYENGSNRIHTI 1282
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Match: nrx-1 (NeuReXin related [Source:UniProtKB/TrEMBL;Acc:I2HAJ7]) HSP 1 Score: 235.343 bits (599), Expect = 4.691e-62 Identity = 268/1133 (23.65%), Postives = 479/1133 (42.28%), Query Frame = 2
Query: 701 CYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEIN---RSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSI-YKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQ-----FRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPV-SFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTID--DSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAK-KLSPLNIELTASLQPA---NVMRQFA-INFHSTKSYLVIPKVNI---FGDFRLEFQMKTLQPSGLLLFLQGESNDY---LILEMVNGLLHIIYNWGSGYK-----RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDY-------GFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSS----EVSSK------------NSFQGFISGLTINEIAILDTLKENFNSYILLI 3934
C F + R C K + LTF + +GY +++ + + ++ FKT S LFY G + ++ V ++DG II S+ + R F NS + DD WH + ++ + + +D + E + + + + F + +P++ P + FRGCMK++ + + +V + + S K DI C V SFT S YL S+ S F+T SD LI Y + H TD+ + E+ D L+ I L S V ++ VS+G H++ L +++D + ++ + ++IG++ + ++ S VWS L ++GCI ++ ++ + I + ++ I GC S E L++C PC N G C + CDC+ TNF G C E E NG + +T S+VE+ + F++ G++ T +G DK+ +F+ + + + L N F ++ D+ WH ++++R + L +++D ++ + +L+ I ++ +G+AF +H ++ F G++ ++NG +Y LAK K++ + ++S + NV + A I+F ++ Y+ I G FR++F+ +TL S LL F + +DY L+M+NG L Y SG + K+ L+D WH+V I + KTH VD + S + + GK++ G S R GF+GCI++ +N + DL ++A+ + V+ C + C D+C+ G+C Q W CDCS T+ SG +C++ STT +F PS + Y+Y+ ++ + ++ F F T TQ L++IE DY G++ Y H+ + DG H+++ + T+++D L + P +++ + +G++ + K +S+QG ISG+ +N + ILD L EN ++ I I
Sbjct: 253 CQFSDHDGRNCEIEKNDGE---LTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYAGD-----------EKSYLHVMLQDGA--IIASSKFDGSDARIIRMF--NSFPSQRYDDDSWHTIILERSLQMMTLIVDGRRDEIRQYAPELDWISNSFGFLGS-----------IPKHNPSKEVNRVSFRGCMKKVRYDIDATRILLVNLADQSYGG--SVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQ---HNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSS-VWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNE---LDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGVLFDTG--ANGKNDKITVFLNDSQLNLFLQDSSTNNTFSWGKSLSDNHWHELQVRRLGQKLLLYLD-GFWSHSIYLQNP---ISVEIDEVGAAFS-----------------VH-SSAPPPRDEHFKGFLSKLVFNGNDY--LAKTKMNSAQLSKSSSRESKGQRNVKTRIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPK-HDYDQSFRLQMLNGRLKYTYR-TSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQD-EKTHDHVLLVD---NSSTTLIIDKIKKVESKMSGKLYFGSNPLGVS---------RPSNGFRGCISTLRINENA--------LDLYEDADSRMKVNRGC----SGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRT-----------TQPNGVLISIECAADQDYFTIFLNKGYLNAHYNLGNRDHTTSYHTRILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMILD-LYENGSNRIHTI 1282
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Match: nrx-1 (NeuReXin related [Source:UniProtKB/TrEMBL;Acc:I2HAJ7]) HSP 1 Score: 230.72 bits (587), Expect = 1.323e-60 Identity = 272/1147 (23.71%), Postives = 480/1147 (41.85%), Query Frame = 2
Query: 701 CYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEIN---RSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSI-YKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKF---AKATEPFQYYRQ-----------TQLPQYPPLSQ-----FRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPV-SFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTID--DSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAK-KLSPLNIELTASLQPA---NVMRQFA-INFHSTKSYLVIPKVNI---FGDFRLEFQMKTLQPSGLLLFLQGESNDY---LILEMVNGLLHIIYNWGSGYK-----RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDY-------GFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSS----EVSSK------------NSFQGFISGLTINEIAILDTLKENFNSYILLI 3934
C F + R C K + LTF + +GY +++ + + ++ FKT S LFY G + ++ V ++DG II S+ + R F NS + DD WH + + ++ + S + + IHM + E QY + +P++ P + FRGCMK++ + + +V + + S K DI C V SFT S YL S+ S F+T SD LI Y + H TD+ + E+ D L+ I L S V ++ VS+G H++ L +++D + ++ + ++IG++ + ++ S VWS L ++GCI ++ ++ + I + ++ I GC S E L++C PC N G C + CDC+ TNF G C E E NG + +T S+VE+ + F++ G++ T +G DK+ +F+ + + + L N F ++ D+ WH ++++R + L +++D ++ + +L+ I ++ +G+AF +H ++ F G++ ++NG +Y LAK K++ + ++S + NV + A I+F ++ Y+ I G FR++F+ +TL S LL F + +DY L+M+NG L Y SG + K+ L+D WH+V I + KTH VD + S + + GK++ G S R GF+GCI++ +N + DL ++A+ + V+ C + C D+C+ G+C Q W CDCS T+ SG +C++ STT +F PS + Y+Y+ ++ + ++ F F T TQ L++IE DY G++ Y H+ + DG H+++ + T+++D L + P +++ + +G++ + K +S+QG ISG+ +N + ILD L EN ++ I I
Sbjct: 253 CQFSDHDGRNCEIEKNDGE---LTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYAGD-----------EKSYLHVMLQDGA--IIASSKFDGSDARIIRMF--NSFPSQRYDDDSWHTIIL--------------ERSLQMHSEEMVA--IHMTLIVDGRRDEIRQYAPELDWISNSFGFLGSIPKHNPSKEVNRVSFRGCMKKVRYDIDATRILLVNLADQSYGG--SVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQ---HNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSS-VWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNE---LDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGVLFDTGA--NGKNDKITVFLNDSQLNLFLQDSSTNNTFSWGKSLSDNHWHELQVRRLGQKLLLYLD-GFWSHSIYLQNP---ISVEIDEVGAAFS-----------------VH-SSAPPPRDEHFKGFLSKLVFNGNDY--LAKTKMNSAQLSKSSSRESKGQRNVKTRIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPK-HDYDQSFRLQMLNGRLKYTYR-TSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQD-EKTHDHVLLVD---NSSTTLIIDKIKKVESKMSGKLYFGSNPLGVS---------RPSNGFRGCISTLRINENA--------LDLYEDADSRMKVNRGC----SGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRT-----------TQPNGVLISIECAADQDYFTIFLNKGYLNAHYNLGNRDHTTSYHTRILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMILD-LYENGSNRIHTI 1291
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Match: nrx-1 (NeuReXin related [Source:UniProtKB/TrEMBL;Acc:I2HAJ7]) HSP 1 Score: 229.565 bits (584), Expect = 2.210e-60 Identity = 270/1146 (23.56%), Postives = 479/1146 (41.80%), Query Frame = 2
Query: 701 CYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEIN---RSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSI-YKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKF---AKATEPFQYYRQ-----------TQLPQYPPLSQ-----FRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPV-SFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTID--DSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAK-KLSPLNIELTASLQPA---NVMRQFA-INFHSTKSYLVIPKVNI---FGDFRLEFQMKTLQPSGLLLFL--QGESNDYLILEMVNGLLHIIYNWGSGYK-----RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDY-------GFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSS----EVSSK------------NSFQGFISGLTINEIAILDTLKENFNSYILLI 3934
C F + R C K + LTF + +GY +++ + + ++ FKT S LFY G + ++ V ++DG II S+ + R F NS + DD WH + + ++ + S + + IHM + E QY + +P++ P + FRGCMK++ + + +V + + S K DI C V SFT S YL S+ S F+T SD LI Y + H TD+ + E+ D L+ I L S V ++ VS+G H++ L +++D + ++ + ++IG++ + ++ S VWS L ++GCI ++ ++ + I + ++ I GC S E L++C PC N G C + CDC+ TNF G C E E NG + +T S+VE+ + F++ G++ T +G DK+ +F+ + + + L N F ++ D+ WH ++++R + L +++D ++ + +L+ I ++ +G+AF +H ++ F G++ ++NG +Y LAK K++ + ++S + NV + A I+F ++ Y+ I G FR++F+ +TL S LL F + + + L+M+NG L Y SG + K+ L+D WH+V I + KTH VD + S + + GK++ G S R GF+GCI++ +N + DL ++A+ + V+ C + C D+C+ G+C Q W CDCS T+ SG +C++ STT +F PS + Y+Y+ ++ + ++ F F T TQ L++IE DY G++ Y H+ + DG H+++ + T+++D L + P +++ + +G++ + K +S+QG ISG+ +N + ILD L EN ++ I I
Sbjct: 253 CQFSDHDGRNCEIEKNDGE---LTFGGDEWVGYDVSLNISAAVRAKKENLTLTFKTVHGTSMLFYAGD-----------EKSYLHVMLQDGA--IIASSKFDGSDARIIRMF--NSFPSQRYDDDSWHTIIL--------------ERSLQMHSEEMVA--IHMTLIVDGRRDEIRQYAPELDWISNSFGFLGSIPKHNPSKEVNRVSFRGCMKKVRYDIDATRILLVNLADQSYGG--SVVKTEGDISYSCKNPSQRSDVLSFTETSSYLTLPRWNSLSSGSLSFHFRTTSSDGLILYHGVMQ---HNATDYVAFELIDSHLFMIINLGSGVVRLQTTSMKVSDGEWHHVQLDRLSRTGSVIVDAIKIDFSTPGVSANLIIDDPIFIGNVPNNSLVYPSS-VWSIALQKGYTGCIKNIRMNGVSTKIGQEFEASNSTGIELGCSLSNE---LDICEPNPCQNFGKCSKNLNSFDCDCSNTNFEGKQCELEQTAVEVNGEESKVHVLAHTKVSQVEHIKIRFRTTSSRGVLFDTGA--NGKNDKITVFLNDSQLNLFLQDSSTNNTFSWGKSLSDNHWHELQVRRLGQKLLLYLD-GFWSHSIYLQNP---ISVEIDEVGAAFS-----------------VH-SSAPPPRDEHFKGFLSKLVFNGNDY--LAKTKMNSAQLSKSSSRESKGQRNVKTRIASISFTNSTGYVAFSSDKISGLTGSFRVQFKFQTLMRSALLFFTLPKHDYDQSFRLQMLNGRLKYTYR-TSGQEFHTTSPKLPHRQHLSDMRWHNVLIYQD-EKTHDHVLLVD---NSSTTLIIDKIKKVESKMSGKLYFGSNPLGVS---------RPSNGFRGCISTLRINENA--------LDLYEDADSRMKVNRGC----SGPIARCIEDACANHGRCIQLWSSIRCDCSLTAHSGDRCQNPSTTVRFDGSPSAIFYEYAPNERPTTSKDYFVFSFRT-----------TQPNGVLISIECAADQDYFTIFLNKGYLNAHYNLGNRDHTTSYHTRILNDGFPHVIKISRTEANMTIQVDKLPSLRYRPKRASDLVLLNMQTRISIGAAFNTRHLDQKRLLRHRRNTEIFDSYQGEISGVNVNGLMILD-LYENGSNRIHTI 1291
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Match: epi-1 (Laminin-like protein epi-1 [Source:UniProtKB/Swiss-Prot;Acc:Q21313]) HSP 1 Score: 62.3882 bits (150), Expect = 3.267e-9 Identity = 69/313 (22.04%), Postives = 125/313 (39.94%), Query Frame = 2
Query: 2099 FNGYQFMRIKF---PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIK--YLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFG-DFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLN---DGLWHSVKIVRHMSKTHSFAFRVDGK 3010
F Q+ RI++ P E F + NG+I N+ TD + + +++G + + G G K+ ++ D +WH+IK+ RR K+ + +DDN YE + +I + + + G D + N ++ + F G + F NG++ + K+ + + + + F Y ++ K G F LE +M+ +G+L + +Y+ +E VNG + GSG + + N DG W S KI + K + V+GK
Sbjct: 3313 FGSQQYSRIEYDILPEAIDKSGE-FTFKIRPTSDNGIIFIATNK---RTDHIAVMLEHGRVVFTYDTGSGQVIIKSDKSIIDGRWHTIKVSRRGKSAHLIVDDNSYESEGAANQNEDLIETQPPFYVGGVPAD--------LAGFARNLVVGV-------RSQFSGCIKDFKLNGKS-LDNGKEF---------GTEQCSQFSEPGMYFGKDGGYAIVQKDYEVGLTFGLEVEMRPRMKNGILFSVG--VLEYITVEFVNGSIKTTVESGSGGEELWHHPDIENQYCDGQWQSFKISK---KRNLLTVAVNGK 3591 HSP 2 Score: 61.2326 bits (147), Expect = 7.138e-9 Identity = 36/118 (30.51%), Postives = 60/118 (50.85%), Query Frame = 2
Query: 2765 RLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVT 3118
++ T P GLL F+ G+ D++ LE+ +G + + + GSG + I+ES NDG WH+V IVR + +DG+ + DVP ++ F +++GG S+ T
Sbjct: 2921 KISLSFLTFSPHGLLFFV-GKDKDFMALELSDGGVKLSVDLGSGVGQWITESSNYNDGKWHTVSIVR---EEKHVKIMIDGETEVLEGDVPGKDSEMSVTEF--LYIGGTPSGLSVRT 3032
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Match: Nrx-1 (gene:FBgn0038975 transcript:FBtr0084256) HSP 1 Score: 308.145 bits (788), Expect = 1.605e-84 Identity = 310/1368 (22.66%), Postives = 565/1368 (41.30%), Query Frame = 2
Query: 146 NSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSA-KVR---------LDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIG-----YNS------------FKRFDGFLGDTMFF---GG--LPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLI----------PVMIQFQSDAMNTCY---FDSNFCRYCSSSKKCT--KYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDI---------VITLDDFQKEFKNLSNQ-QLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTY--KSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-------LNIELTASLQPANVMRQF-AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNN---SVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKN----SFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQS 4003
N +L + K + GL+ Y +D T F LKL+ A ++R + VG HD + + + D T +I +DG+ + T K QF +F+ ++ +G Y+S RF G + + ++ GG +++KQ + R +R VR + I S + C +D +C + + T ++L++D +G ++S + +I+F F+T+Q N LFY G T ++++ + DG + + ++ H D +WH V + +I V +DD + +++ + + + + A P L + F GC++++ + + LN++++ G L C P PV+FT + +L + +++ S F+T + + +I SK+ + +IE+ + +Y + L S S V +G H+++L ++ +D + +E +G +Y+G + +S +W+ L F GC+ L + I + ++ ++S+ C NVC PC N G C W++ CDC+ T + G TC +E FNG Q M I N K++ E + FK+ P GL+L T + S + D+LEI + G + + K ++ D+ WH+I+ RR NL++ +D + + I+ + +G F +IQ +S+ M N F+G M ++NG+ Y ++ K L P +LTA + + + A F S SY+ + + + ++F+ KT++P+GLL+F G ND++ +E+VNG +H ++ G G +S + +ND WH V I R KTH+ DDS + + ++ G +++GG ++ + + + S+ GF+GC+AS + + S+++D V+ V C + CS ++C+ G C Q W Y+C+C TS++GP C D S +F + + Y + + + +A GF T TR A L+ + +S + +E++IV G I + Y + E V D YH+VRF++ ATL+LDD + + P + + G + +N F G I+GL++N++ ILD E + +I + + + LV R Q ++Q+
Sbjct: 125 NGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN-----DEQTSLI----VDGVSQQRST-------KGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYD----LGQTGAEPIVSAQD-AISFYFRTRQPNGLLFYTGH-----------GTDYLNLALRDGGVSLTMGLANG------KQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNP------RALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ-CPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-----NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAE-SNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRAETILGRHSTMEIRSVHLGGLFHAEEEIQMTST---------------MPN--FVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTV------DDSFEIISLTGNNMHLELAGILYIGGVFKD--MYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVV----------PSSLVVSGC-----EGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFIT-TRPDAVLLRV---ESATTQDYMELEIVE--GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVER-DPHITI--RGDVQLVTGVLDRNDLQRMQQT 1392
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Match: Nrx-1 (gene:FBgn0038975 transcript:FBtr0334607) HSP 1 Score: 308.145 bits (788), Expect = 1.605e-84 Identity = 310/1368 (22.66%), Postives = 565/1368 (41.30%), Query Frame = 2
Query: 146 NSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSA-KVR---------LDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIG-----YNS------------FKRFDGFLGDTMFF---GG--LPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLI----------PVMIQFQSDAMNTCY---FDSNFCRYCSSSKKCT--KYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDI---------VITLDDFQKEFKNLSNQ-QLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTY--KSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-------LNIELTASLQPANVMRQF-AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNN---SVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKN----SFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQS 4003
N +L + K + GL+ Y +D T F LKL+ A ++R + VG HD + + + D T +I +DG+ + T K QF +F+ ++ +G Y+S RF G + + ++ GG +++KQ + R +R VR + I S + C +D +C + + T ++L++D +G ++S + +I+F F+T+Q N LFY G T ++++ + DG + + ++ H D +WH V + +I V +DD + +++ + + + + A P L + F GC++++ + + LN++++ G L C P PV+FT + +L + +++ S F+T + + +I SK+ + +IE+ + +Y + L S S V +G H+++L ++ +D + +E +G +Y+G + +S +W+ L F GC+ L + I + ++ ++S+ C NVC PC N G C W++ CDC+ T + G TC +E FNG Q M I N K++ E + FK+ P GL+L T + S + D+LEI + G + + K ++ D+ WH+I+ RR NL++ +D + + I+ + +G F +IQ +S+ M N F+G M ++NG+ Y ++ K L P +LTA + + + A F S SY+ + + + ++F+ KT++P+GLL+F G ND++ +E+VNG +H ++ G G +S + +ND WH V I R KTH+ DDS + + ++ G +++GG ++ + + + S+ GF+GC+AS + + S+++D V+ V C + CS ++C+ G C Q W Y+C+C TS++GP C D S +F + + Y + + + +A GF T TR A L+ + +S + +E++IV G I + Y + E V D YH+VRF++ ATL+LDD + + P + + G + +N F G I+GL++N++ ILD E + +I + + + LV R Q ++Q+
Sbjct: 125 NGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN-----DEQTSLI----VDGVSQQRST-------KGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYD----LGQTGAEPIVSAQD-AISFYFRTRQPNGLLFYTGH-----------GTDYLNLALRDGGVSLTMGLANG------KQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNP------RALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ-CPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-----NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAE-SNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRAETILGRHSTMEIRSVHLGGLFHAEEEIQMTST---------------MPN--FVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTV------DDSFEIISLTGNNMHLELAGILYIGGVFKD--MYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVV----------PSSLVVSGC-----EGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFIT-TRPDAVLLRV---ESATTQDYMELEIVE--GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVER-DPHITI--RGDVQLVTGVLDRNDLQRMQQT 1392
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Match: Nrx-1 (gene:FBgn0038975 transcript:FBtr0334610) HSP 1 Score: 306.99 bits (785), Expect = 3.497e-84 Identity = 313/1374 (22.78%), Postives = 567/1374 (41.27%), Query Frame = 2
Query: 146 NSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSA-KVR---------LDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIG-----YNS------------FKRFDGFLGDTMFF---GG--LPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLI----------PVMIQFQSDAMNTCY---FDSNFCRYCSSSKKCT--KYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDI---------VITLDDFQKEFKNLSNQ-QLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTY--KSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIG------IKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-------LNIELTASLQPANVMRQF-AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNN---SVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKN----SFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQS 4003
N +L + K + GL+ Y +D T F LKL+ A ++R + VG HD + + + D T +I +DG+ + T K QF +F+ ++ +G Y+S RF G + + ++ GG +++KQ + R +R VR + I S + C +D +C + + T ++L++D +G ++S + +I+F F+T+Q N LFY G T ++++ + DG + + ++ H D +WH V + +I V +DD + +++ + + + + A P L + F GC++++ + + LN++++ G L C P PV+FT + +L + +++ S F+T + + +I SK+ + +IE+ + +Y + L S S V +G H+++L ++ +D + +E +G +Y+G + +S +W+ L F GC+ L + I + ++ ++S+ C NVC PC N G C W++ CDC+ T + G TC +E FNG Q M I N K++ E + FK+ P GL+L T + S + D+LEI + G + + K ++ D+ WH+I+ RR NL++ +D E I+G I+ + +G F +IQ +S+ M N F+G M ++NG+ Y ++ K L P +LTA + + + A F S SY+ + + + ++F+ KT++P+GLL+F G ND++ +E+VNG +H ++ G G +S + +ND WH V I R KTH+ DDS + + ++ G +++GG ++ + + + S+ GF+GC+AS + + S+++D V+ V C + CS ++C+ G C Q W Y+C+C TS++GP C D S +F + + Y + + + +A GF T TR A L+ + +S + +E++IV G I + Y + E V D YH+VRF++ ATL+LDD + + P + + G + +N F G I+GL++N++ ILD E + +I + + + LV R Q ++Q+
Sbjct: 125 NGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN-----DEQTSLI----VDGVSQQRST-------KGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYD----LGQTGAEPIVSAQD-AISFYFRTRQPNGLLFYTGH-----------GTDYLNLALRDGGVSLTMGLANG------KQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNP------RALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ-CPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-----NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAE-SNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSET---ILGRHSTMEIRSVHLGGLFHAEEEIQMTST---------------MPN--FVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTV------DDSFEIISLTGNNMHLELAGILYIGGVFKD--MYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVV----------PSSLVVSGC-----EGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFIT-TRPDAVLLRV---ESATTQDYMELEIVE--GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVER-DPHITI--RGDVQLVTGVLDRNDLQRMQQT 1395
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Match: Nrx-1 (gene:FBgn0038975 transcript:FBtr0334612) HSP 1 Score: 306.99 bits (785), Expect = 3.618e-84 Identity = 313/1374 (22.78%), Postives = 567/1374 (41.27%), Query Frame = 2
Query: 146 NSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSA-KVR---------LDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIG-----YNS------------FKRFDGFLGDTMFF---GG--LPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLI----------PVMIQFQSDAMNTCY---FDSNFCRYCSSSKKCT--KYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDI---------VITLDDFQKEFKNLSNQ-QLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTY--KSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIG------IKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-------LNIELTASLQPANVMRQF-AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNN---SVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKN----SFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQS 4003
N +L + K + GL+ Y +D T F LKL+ A ++R + VG HD + + + D T +I +DG+ + T K QF +F+ ++ +G Y+S RF G + + ++ GG +++KQ + R +R VR + I S + C +D +C + + T ++L++D +G ++S + +I+F F+T+Q N LFY G T ++++ + DG + + ++ H D +WH V + +I V +DD + +++ + + + + A P L + F GC++++ + + LN++++ G L C P PV+FT + +L + +++ S F+T + + +I SK+ + +IE+ + +Y + L S S V +G H+++L ++ +D + +E +G +Y+G + +S +W+ L F GC+ L + I + ++ ++S+ C NVC PC N G C W++ CDC+ T + G TC +E FNG Q M I N K++ E + FK+ P GL+L T + S + D+LEI + G + + K ++ D+ WH+I+ RR NL++ +D E I+G I+ + +G F +IQ +S+ M N F+G M ++NG+ Y ++ K L P +LTA + + + A F S SY+ + + + ++F+ KT++P+GLL+F G ND++ +E+VNG +H ++ G G +S + +ND WH V I R KTH+ DDS + + ++ G +++GG ++ + + + S+ GF+GC+AS + + S+++D V+ V C + CS ++C+ G C Q W Y+C+C TS++GP C D S +F + + Y + + + +A GF T TR A L+ + +S + +E++IV G I + Y + E V D YH+VRF++ ATL+LDD + + P + + G + +N F G I+GL++N++ ILD E + +I + + + LV R Q ++Q+
Sbjct: 125 NGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN-----DEQTSLI----VDGVSQQRST-------KGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYD----LGQTGAEPIVSAQD-AISFYFRTRQPNGLLFYTGH-----------GTDYLNLALRDGGVSLTMGLANG------KQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNP------RALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ-CPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-----NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAE-SNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSET---ILGRHSTMEIRSVHLGGLFHAEEEIQMTST---------------MPN--FVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTV------DDSFEIISLTGNNMHLELAGILYIGGVFKD--MYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVV----------PSSLVVSGC-----EGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFIT-TRPDAVLLRV---ESATTQDYMELEIVE--GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVER-DPHITI--RGDVQLVTGVLDRNDLQRMQQT 1395
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Match: Nrx-1 (gene:FBgn0038975 transcript:FBtr0334608) HSP 1 Score: 306.99 bits (785), Expect = 3.618e-84 Identity = 313/1374 (22.78%), Postives = 567/1374 (41.27%), Query Frame = 2
Query: 146 NSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSA-KVR---------LDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIG-----YNS------------FKRFDGFLGDTMFF---GG--LPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLI----------PVMIQFQSDAMNTCY---FDSNFCRYCSSSKKCT--KYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDI---------VITLDDFQKEFKNLSNQ-QLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTY--KSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIG------IKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-------LNIELTASLQPANVMRQF-AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNN---SVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKN----SFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQS 4003
N +L + K + GL+ Y +D T F LKL+ A ++R + VG HD + + + D T +I +DG+ + T K QF +F+ ++ +G Y+S RF G + + ++ GG +++KQ + R +R VR + I S + C +D +C + + T ++L++D +G ++S + +I+F F+T+Q N LFY G T ++++ + DG + + ++ H D +WH V + +I V +DD + +++ + + + + A P L + F GC++++ + + LN++++ G L C P PV+FT + +L + +++ S F+T + + +I SK+ + +IE+ + +Y + L S S V +G H+++L ++ +D + +E +G +Y+G + +S +W+ L F GC+ L + I + ++ ++S+ C NVC PC N G C W++ CDC+ T + G TC +E FNG Q M I N K++ E + FK+ P GL+L T + S + D+LEI + G + + K ++ D+ WH+I+ RR NL++ +D E I+G I+ + +G F +IQ +S+ M N F+G M ++NG+ Y ++ K L P +LTA + + + A F S SY+ + + + ++F+ KT++P+GLL+F G ND++ +E+VNG +H ++ G G +S + +ND WH V I R KTH+ DDS + + ++ G +++GG ++ + + + S+ GF+GC+AS + + S+++D V+ V C + CS ++C+ G C Q W Y+C+C TS++GP C D S +F + + Y + + + +A GF T TR A L+ + +S + +E++IV G I + Y + E V D YH+VRF++ ATL+LDD + + P + + G + +N F G I+GL++N++ ILD E + +I + + + LV R Q ++Q+
Sbjct: 125 NGTLELEFKTEQPNGLVLYTDDGGTYDFFELKLVEGALRLRYNLGGGAQIITVGRELHDGHWHKVQVLRN-----DEQTSLI----VDGVSQQRST-------KGKEFQFGKFASNSDVYVGGMPNWYSSKLALLALPSVIFEPRFRGAIRNLVYADQPGGSTRRQEIKQQRDIKCGDVPCDHGELPARERPLRGVRGGNTTDACERNDPCQHGGICISTDSGPICECRNLEYDGQYCEKEKAPSEATFRGTQFLSYD----LGQTGAEPIVSAQD-AISFYFRTRQPNGLLFYTGH-----------GTDYLNLALRDGGVSLTMGLANG------KQEMHIKPSKVRFDDHQWHKVTVHRRIQEISSITSFCRLVTVVDDVYTDHSHIAGKFTMLSSSRVYVGGAVNP------RALLGARVHTNFVGCLRKVEFSADTLNLNLIDLAKSGSKLIQVAGNLEYQ-CPSGDPQDPVTFTTRESHLVLPPWETGKQSSISFKFRTKEPNGIIVLATGSKQPRAKNPVLIAIELLNGHIYIHLDLGSGASKVRASRRRVDDGDWHDLILRRNGRDAKVSVDGVWNDFRTPGDGTILELDGHMYLGGVGPAYNSVSWPAAIWTATLRQGFVGCLRDLVLSGKAIDIAAFARVQDSASVKPSCHVQA-----NVCNGNPCLNGGTCLEGWNRPICDCSATLYGGPTCGRELATLAFNGSQHMTIWLGNGQGTKTQTEELVIRFKTSRPAGLLLLTSAE-SNSPDRLEIALVAGRVRASVRLSDREKNLLAGQSVLNDNNWHTIRFSRRASNLRLQVDGAPPVRGMLSET---ILGRHSTMEIRSVHLGGLFHAEEEIQMTST---------------MPN--FVGQMQGLVFNGQRYLDIVKSLGPELSALPSATFKLTARFVNSPAGQPYHAATFRSKHSYVGLAMLKAYNSISIDFRFKTVEPNGLLVFNGGRRNDFVAVELVNGHIHYTFDLGDGPVTMRDKSRIHMNDNRWHQVSIRRPGPKTHTLTV------DDSFEIISLTGNNMHLELAGILYIGGVFKD--MYSKLPASISSRSGFEGCLASLDLGDASPSLTSDAVV----------PSSLVVSGC-----EGPTKCSQNACANRGNCVQQWNAYACECDMTSYTGPTCYDESIAYEFGNNKGMVQYTFPENAQADTEEDNIALGFIT-TRPDAVLLRV---ESATTQDYMELEIVE--GNIFMVYNIGSVDLPLGEIGTKVNDNAYHVVRFQRKGGNATLQLDDYNVQALTPQSHHSTVFNTMSNVQVGGKFSRNGRNRIERPFAGVIAGLSVNKLRILDLAVER-DPHITI--RGDVQLVTGVLDRNDLQRMQQT 1395
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Match: nrxn1a (neurexin 1a [Source:NCBI gene;Acc:565531]) HSP 1 Score: 325.865 bits (834), Expect = 1.718e-90 Identity = 364/1558 (23.36%), Postives = 630/1558 (40.44%), Query Frame = 2
Query: 92 FIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT--CYFD-----SNFCRY--------CSSS----KKCT--KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCP-----DNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQC-PGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPF--EYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
F G P N S +SF +K + GL+ Y +D F+ L L+ + ++ L +F + T D + D WH + + + K+ L ++ + V + KR D + +F GG+P +L+ A SSAI E + G I+ +R+ PV+I SD +N+ C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N +G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C + C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E PN R + S + + P + T Q + R + P IT+ N Q K + T ++ S P E + P D +++ + K P E +S+ ++ A ++ L +Y+ +DEGSY+V E R
Sbjct: 30 FTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVYFDDEGFCDFLEL-LIHNGRLSLRFSIFCAEPA-----------------TVFSDTAVND---SRWHAVTLRRNFKNTTLVVDEEIKWVEV-----KSKRRDMTVFSHLFLGGIPPELRSVALR--LTSSAIKDEVPYKGWITNLRVNGSE-----PVLIG--SDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVV-AFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGCEVALLKADLQGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEGD---------------PNV---RVEGSARLVGDMPSSSITPQSSVSAAGNRSETSPSITDI-----------------TTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDP-CDPSSAHPPLPEAKGYPSPEVIRESSSTTG--MVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESR 1432 HSP 2 Score: 155.606 bits (392), Expect = 2.063e-37 Identity = 187/901 (20.75%), Postives = 369/901 (40.95%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN--KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIE-----IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E +++ + I++ T+ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 846
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Match: nrxn1a (neurexin 1a [Source:NCBI gene;Acc:565531]) HSP 1 Score: 325.094 bits (832), Expect = 2.564e-90 Identity = 345/1460 (23.63%), Postives = 596/1460 (40.82%), Query Frame = 2
Query: 392 EWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT--CYFD-----SNFCRY--------CSSS----KKCT------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQC-PGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPF--EYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
WH + + + K+ L ++ + V + KR D + +F GG+P +L+ A SSAI E + G I+ +R+ PV+I SD +N+ C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N G+G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E PN R + S + + P + T Q + R + P IT+ N Q K + T ++ S P E + P D +++ + K P E +S+ ++ A ++ L +Y+ +DEGSY+V E R
Sbjct: 109 RWHAVTLRRNFKNTTLVVDEEIKWVEV-----KSKRRDMTVFSHLFLGGIPPELRSVALR--LTSSAIKDEVPYKGWITNLRVNGSE-----PVLIG--SDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFK-CENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLGKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGC----EGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEGD---------------PNV---RVEGSARLVGDMPSSSITPQSSVSAAGNRSETSPSITDI-----------------TTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDP-CDPSSAHPPLPEAKGYPSPEVIRESSSTTG--MVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESR 1430 HSP 2 Score: 149.443 bits (376), Expect = 1.712e-35 Identity = 187/912 (20.50%), Postives = 366/912 (40.13%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN------------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E+ D G +++ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLEL----DGGRVRLTVNLGKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 853
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Match: nrxn1a (neurexin 1a [Source:NCBI gene;Acc:565531]) HSP 1 Score: 315.849 bits (808), Expect = 2.693e-87 Identity = 360/1554 (23.17%), Postives = 624/1554 (40.15%), Query Frame = 2
Query: 149 SSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT--CYFD-----SNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQC-PGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPF--EYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
S +SF +K + GL+ Y +D F+ L L+ + ++ L +F + T D + D WH + + + K+ L ++ + V + KR D + +F GG+P +L+ A SSAI E + G I+ +R+ PV+I SD +N+ C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N +G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E PN R + S + + P + T Q + R + P IT+ N Q K + T ++ S P E + P D +++ + K P E +S+ ++ A ++ L +Y+ +DEGSY+V E R
Sbjct: 49 SEMSFNMKTKSAHGLLVYFDDEGFCDFLEL-LIHNGRLSLRFSIFCAEPA-----------------TVFSDTAVND---SRWHAVTLRRNFKNTTLVVDEEIKWVEV-----KSKRRDMTVFSHLFLGGIPPELRSVALR--LTSSAIKDEVPYKGWITNLRVNGSE-----PVLIG--SDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFK-CENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGC----EGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEGD---------------PNV---RVEGSARLVGDMPSSSITPQSSVSAAGNRSETSPSITDI-----------------TTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDP-CDPSSAHPPLPEAKGYPSPEVIRESSSTTG--MVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESR 1443 HSP 2 Score: 147.517 bits (371), Expect = 5.416e-35 Identity = 187/921 (20.30%), Postives = 369/921 (40.07%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIE-----IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E +++ + I++ T+ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 866
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Match: nrxn1a (neurexin 1a [Source:NCBI gene;Acc:565531]) HSP 1 Score: 314.694 bits (805), Expect = 6.713e-87 Identity = 344/1469 (23.42%), Postives = 595/1469 (40.50%), Query Frame = 2
Query: 392 EWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT--CYFD-----SNFCRY--------CSSS----KKCT------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQC-PGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPF--EYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
WH + + + K+ L ++ + V + KR D + +F GG+P +L+ A SSAI E + G I+ +R+ PV+I SD +N+ C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N +G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E PN R + S + + P + T Q + R + P IT+ N Q K + T ++ S P E + P D +++ + K P E +S+ ++ A ++ L +Y+ +DEGSY+V E R
Sbjct: 109 RWHAVTLRRNFKNTTLVVDEEIKWVEV-----KSKRRDMTVFSHLFLGGIPPELRSVALR--LTSSAIKDEVPYKGWITNLRVNGSE-----PVLIG--SDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFK-CENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGC----EGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEGD---------------PNV---RVEGSARLVGDMPSSSITPQSSVSAAGNRSETSPSITDI-----------------TTTTASNRQGKQTTTPQDDLLVASAECPSDDEDIDP-CDPSSAHPPLPEAKGYPSPEVIRESSSTTG--MVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESR 1439 HSP 2 Score: 149.443 bits (376), Expect = 1.706e-35 Identity = 187/917 (20.39%), Postives = 369/917 (40.24%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN------------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIE-----IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E +++ + I++ T+ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 862
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Match: nrxn1a (neurexin 1a [Source:NCBI gene;Acc:565531]) HSP 1 Score: 313.153 bits (801), Expect = 1.883e-86 Identity = 325/1370 (23.72%), Postives = 564/1370 (41.17%), Query Frame = 2
Query: 149 SSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT--CYFD-----SNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN 3910
S +SF +K + GL+ Y +D F+ L L+ + ++ L +F + T D + D WH + + + K+ L ++ + V + KR D + +F GG+P +L+ A SSAI E + G I+ +R+ PV+I SD +N+ C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N +G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E
Sbjct: 49 SEMSFNMKTKSAHGLLVYFDDEGFCDFLEL-LIHNGRLSLRFSIFCAEPA-----------------TVFSDTAVND---SRWHAVTLRRNFKNTTLVVDEEIKWVEV-----KSKRRDMTVFSHLFLGGIPPELRSVALR--LTSSAIKDEVPYKGWITNLRVNGSE-----PVLIG--SDGVNSDICEADHICLNGGVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFK-CENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGC----EGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEG 1297 HSP 2 Score: 147.132 bits (370), Expect = 7.056e-35 Identity = 187/921 (20.30%), Postives = 369/921 (40.07%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIE-----IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E +++ + I++ T+ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 866
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Match: NRXN3 (neurexin 3 [Source:NCBI gene;Acc:100379902]) HSP 1 Score: 310.457 bits (794), Expect = 1.837e-85 Identity = 298/1268 (23.50%), Postives = 525/1268 (41.40%), Query Frame = 2
Query: 134 NVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKI-DGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDA-------SHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYF-DSNFCRYCSSSKKCTKY-------EYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPD-----NHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
+ +T S LSFQ++ + GL+ Y +D F+ L L H R +I ++ T I+ K+ DG WH +M++ ++ L + ++ P ++ + D +F GG+P ++ A F ++ + + +RL L + + + C D C+++ K+ TF + + Y + I + I FKT+Q N + + G + + + G F I+ KF+ D++WH V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + + K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K I +T DF+++E+ D LY + + S +N ++G ++ + + I ++ + S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N C+ W++ CDCT T G TC +EA I ++G +M+I P +E E+ L FKS+ GL+++T ++ S T +LE + G + +++N +G + + D++WH++++ RR K LK+ +DD+ E GT + D + N KR + F+G++ ++NG Y +L K EL A +++ + F + SYL + + + L FQ KT+ P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ D++A V G N + G++++ G + QS+ + + S+ GFQGC+AS +N + DL+ +A + ++ C D N C DSC+ G C Q W ++CDCS TS+SG C D T F K ++Y + + S ++LA GF T T K L+ I L L + I G I V + + S E V DG YH+V++ ++ ATL++D+ H P G
Sbjct: 44 DASTRSDLSFQLRTNVSAGLLLYFDDGGICDFLCLSLADG-----------HVQLRFSIDCAE---------TAIVSDKKVNDG---GWHFLMLSRNRLRTTLVLDGEAK----PGEVRPQRQHMNIVSD-LFVGGVPSDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRLLGSHGARLDLEGLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGKSADYVNLALKGGAVSLVINLGSGAFEAIVEPTND--------KFN---------DNEWHEVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIG----DTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNA--AGVKSSCSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMHTEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLE--LDGGKVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKTLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIAD-PVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDNSNTHTLKV-------DTKAVTQVINGAKNLDLKGELYIAGLV--QSMYSTLPKLVASRDGFQGCLASVDLNGRL--------PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFST-TVKEGILVRIDSAPGLMDYLQLHIV----QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGG 1199
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Match: NRXN3 (neurexin 3 [Source:NCBI gene;Acc:100379902]) HSP 1 Score: 309.686 bits (792), Expect = 7.703e-85 Identity = 297/1268 (23.42%), Postives = 530/1268 (41.80%), Query Frame = 2
Query: 134 NVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKI-DGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDA-------SHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYF-DSNFCRYCSSSKKCTKY-------EYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPD-----NHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
+ +T S LSFQ++ + GL+ Y +D F+ L L H R +I ++ T I+ K+ DG WH +M++ ++ L + ++ P ++ + D +F GG+P ++ A F ++ + + +RL L + + + C D C+++ K+ TF + + Y + I + I FKT+Q N + + G ++++ ++ G ++I+ +F N + D++WH V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + + K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K I +T DF+++E+ D LY + + S +N ++G ++ + + I ++ + S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N C+ W++ CDCT T G TC +EA I ++G +M+I P +E E+ L FKS+ GL+++T ++ S T +LE + G + +++N +G + + D++WH++++ RR K LK+ +DD+ E GT + D + N KR + F+G++ ++NG Y +L K EL A +++ + F + SYL + + + L FQ KT+ P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ D++A V G N + G++++ G + QS+ + + S+ GFQGC+AS +N + DL+ +A + ++ C D N C DSC+ G C Q W ++CDCS TS+SG C D T F K ++Y + + S ++LA GF T T K L+ I L L + I G I V + + S E V DG YH+V++ ++ ATL++D+ H P G
Sbjct: 44 DASTRSDLSFQLRTNVSAGLLLYFDDGGICDFLCLSLADG-----------HVQLRFSIDCAE---------TAIVSDKKVNDG---GWHFLMLSRNRLRTTLVLDGEAK----PGEVRPQRQHMNIVSD-LFVGGVPSDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRLLGSHGARLDLEGLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGK-----------SADYVNLALKGGAVSLVIN---LGSGAFEAIVEPTNDKFN---DNEWHEVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIG----DTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNA--AGVKSSCSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMHTEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLE--LDGGKVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKTLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIAD-PVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDNSNTHTLKV-------DTKAVTQVINGAKNLDLKGELYIAGLV--QSMYSTLPKLVASRDGFQGCLASVDLNGRL--------PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFST-TVKEGILVRIDSAPGLMDYLQLHIV----QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGG 1199
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Match: NRXN3 (neurexin 3 [Source:NCBI gene;Acc:100379902]) HSP 1 Score: 306.22 bits (783), Expect = 1.140e-83 Identity = 260/1047 (24.83%), Postives = 455/1047 (43.46%), Query Frame = 2
Query: 746 KCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPD-----NHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
K + TF + + Y + I + I FKT+Q N + + G ++++ ++ G ++I+ +F N + D++WH V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + + K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K I +T DF+++E+ D LY + + S +N ++G ++ + + I ++ + S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N C+ W++ CDCT T G TC +EA I ++G +M+I P +E E+ L FKS+ GL+++T ++ S T +LE + G + +++N G+G + + D++WH++++ RR K LK+ +DD+ E GT + D + N KR + F+G++ ++NG Y +L K EL A +++ + F + SYL + + + L FQ KT+ P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ D++A V G N + G++++ G + QS+ + + S+ GFQGC+AS +N + DL+ +A + ++ C D N C DSC+ G C Q W ++CDCS TS+SG C D T F K ++Y + + S ++LA GF T T K L+ I L L + I G I V + + S E V DG YH+V++ ++ ATL++D+ H P G
Sbjct: 256 KAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGK-----------SADYVNLALKGGAVSLVIN---LGSGAFEAIVEPTNDKFN---DNEWHEVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIG----DTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNA--AGVKSSCSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMHTEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLE--LDGGKVKLMVNLGKGPETLYAGQKLNDNEWHTVRVVRRGKTLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIAD-PVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDNSNTHTLKV-------DTKAVTQVINGAKNLDLKGELYIAGLV--QSMYSTLPKLVASRDGFQGCLASVDLNGRL--------PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFST-TVKEGILVRIDSAPGLMDYLQLHIV----QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGG 1218 HSP 2 Score: 116.316 bits (290), Expect = 2.701e-25 Identity = 177/837 (21.15%), Postives = 332/837 (39.67%), Query Frame = 2
Query: 1460 KAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRD--FALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIY-NGRNYFELAKKL----SPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN-------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHS-FMESRLNVIDGLYHIVRFRKDRMAATLKL---DDLSDRIHVPD 3766
++ S +T+ S L+ Y GI DF + + D L FSI + ++S+ V++G H ++L ++LD E + + L++G + + I S + + S + F+G + + ++ +L S G + E +C PC N G C + + +CDCT T + G C+ +E +A F G +++ N +S + L FK++ NGLIL T + D + + ++ G++ +++N G G N KF D++WH +K+ R NL+ ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y N EL++ + + I + NV I+F S ++Y+ +PK N + F +T +P+GL+LF G+ D+ +E+++G L+++ + GSG + + + NDG W V I R ++ + + P + + + + G M+LGG EN++ + E T G+ GCI +++ K++ L EA V +C + C C C W ++ CDC+ T G CE ++ + Y+ ++ ++ F++ R + L++ S L ++ D G +++ G + + +LN D +H VR R TLKL DD+++ V D
Sbjct: 48 RSDLSFQLRTNVSAGLLLY--FDDGGI---CDFLCLSLADGHVQLRFSI---DCAETAIVSDKKVNDGGWHFLMLSRNRLRTTLVLDGEAKPGEVRPQRQHMNIVSDLFVGGVP-SDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRL--------LGSHGARLDLE----GLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEDVNDIPGLAHLMIDDQGRSKAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGK----SADYVNLALKGGAVSLVINLGSGAFEAIVEPTNDKFN------DNEWHEVKVTR---NLRQ---------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRD-GRSGTISVNTKRTPFTASGESEI------LDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR--------SKNIRQLAEAQNAAGVKSSCSRLSGKQ---CDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSY-DGGMYMKIIMPVVMHTEAEDVSLRFKSQ-RAYGLLVATTSRDSADTL-----RLELDGGKVKLMVNLGKGPETLYAGQKLN--DNEWHTVRVV--RRGKTLKLTVDDDVAEGTMVGD 807
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Match: NRXN3 (neurexin 3 [Source:NCBI gene;Acc:100379902]) HSP 1 Score: 303.523 bits (776), Expect = 7.075e-83 Identity = 298/1276 (23.35%), Postives = 532/1276 (41.69%), Query Frame = 2
Query: 134 NVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKI-DGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDA-------SHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYF-DSNFCRYCSSSKKCTKY-------EYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPD-----NHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
+ +T S LSFQ++ + GL+ Y +D F+ L L H R +I ++ T I+ K+ DG WH +M++ ++ L + ++ P ++ + D +F GG+P ++ A F ++ + + +RL L + + + C D C+++ K+ TF + + Y + I + I FKT+Q N + + G ++++ ++ G ++I+ +F N + D++WH V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + + K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K I +T DF+++E+ D LY + + S +N ++G ++ + + I ++ + S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N C+ W++ CDCT T G TC +EA I ++G +M+I P +E E+ L FKS+ GL+++T ++ S T +LE + G + +++N +G + + D++WH++++ RR K LK+ +DD+ E GT + D + N KR + F+G++ ++NG Y +L K EL A +++ + F + SYL + + + L FQ KT+ P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ D++A V G N + G++++ G + QS+ + + S+ GFQGC+AS +N + DL+ +A + ++ C D N C DSC+ G C Q W ++CDCS TS+SG C D T F K ++Y + + S ++LA GF T T K L+ I L L + I G I V + + S E V DG YH+V++ ++ ATL++D+ H P G
Sbjct: 44 DASTRSDLSFQLRTNVSAGLLLYFDDGGICDFLCLSLADG-----------HVQLRFSIDCAE---------TAIVSDKKVNDG---GWHFLMLSRNRLRTTLVLDGEAK----PGEVRPQRQHMNIVSD-LFVGGVPSDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRLLGSHGARLDLEGLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGK-----------SADYVNLALKGGAVSLVIN---LGSGAFEAIVEPTNDKFN---DNEWHEVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIG----DTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNA--AGVKSSCSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMHTEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLE--LDGGKVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKTLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIAD-PVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDNSNTHTLKV-------DTKAVTQVINGAKNLDLKGELYIAGLV--QSMYSTLPKLVASRDGFQGCLASVDLNGRL--------PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFST-TVKEGILVRIDSAPGLMDYLQLHIV----QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGG 1207
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Match: NRXN3 (neurexin 3 [Source:NCBI gene;Acc:100379902]) HSP 1 Score: 301.982 bits (772), Expect = 7.484e-83 Identity = 259/1048 (24.71%), Postives = 447/1048 (42.65%), Query Frame = 2
Query: 746 KCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPD-----NHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
K + TF + + Y + I + I FKT+Q N + + G + + + G F I+ KF+ D++WH V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + + K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K I +T DF+++E+ D LY + + S +N ++G ++ + + I ++ + S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N C+ W++ CDCT T G TC +EA I ++G +M+I P +E E+ L FKS+ GL+++T ++ S T +LE + G + +++N +G + + D++WH++++ RR K LK+ +DD+ E GT + D + N KR + F+G++ ++NG Y +L K EL A +++ + F + SYL + + + L FQ KT+ P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ D++A V G N + G++++ G + QS+ + + S+ GFQGC+AS +N + DL+ +A + ++ C D N C DSC+ G C Q W ++CDCS TS+SG C D T F K ++Y + + S ++LA GF T T K L+ I L L + I G I V + + S E V DG YH+V++ ++ ATL++D+ H P G
Sbjct: 256 KAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGKSADYVNLALKGGAVSLVINLGSGAFEAIVEPTND--------KFN---------DNEWHEVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIG----DTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRDGRSGTISVNTKRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEAQNA--AGVKSSCSRLSGKQCDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSYDGGMYMKIIMPVVMHTEAEDVSLRFKSQRAYGLLVATTSRDSADTLRLE--LDGGKVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKTLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGFMTEKRFASAVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGMRSIIAD-PVTFRTKASYLTLSTLQAYTSMHLFFQFKTISPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSERPLNDNQWHNVVITRDNSNTHTLKV-------DTKAVTQVINGAKNLDLKGELYIAGLV--QSMYSTLPKLVASRDGFQGCLASVDLNGRL--------PDLIGDALHRSGQIERGCEDALTKANLQGPTTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNHCNDPGATYIFGKSGGLILYTWPHNDRPSTRTDRLAVGFST-TVKEGILVRIDSAPGLMDYLQLHIV----QGKIGVTFNIGSQDISIREESAPVNDGKYHVVKYTRNGGNATLQVDNWPVNEHYPGG 1219 HSP 2 Score: 120.553 bits (301), Expect = 1.404e-26 Identity = 177/835 (21.20%), Postives = 334/835 (40.00%), Query Frame = 2
Query: 1460 KAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRD--FALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIK-YLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIY-NGRNYFELAKKL----SPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN-------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPL-LTIE---IKIVNDYGFIQVEYYTNTGTHS-FMESRLNVIDGLYHIVRFRKDRMAATLKL---DDLSDRIHVPD 3766
++ S +T+ S L+ Y GI DF + + D L FSI + ++S+ V++G H ++L ++LD E + + L++G + + I S + + S + F+G + + ++ +L S G + E +C PC N G C + + +CDCT T + G C+ +E +A F G +++ N +S + L FK++ NGLIL T + D + + ++ G++ +++N G G N KF D++WH +K+ R + + + +D + + D ++G + +G + D VSN+ FMG + +Y N EL++ + + I + NV I+F S ++Y+ +PK N + F +T +P+GL+LF G+ D+ +E+++G L+++ + GSG + + + NDG W V I R ++ + + P + + + + G M+LGG EN++ + E T G+ GCI +++ K++ L EA V +C + C C C W ++ CDC+ T G CE ++ + Y+ ++ ++ F++ R + L++ S L L ++ +K++ + I++ ++ G + + +LN D +H VR R TLKL DD+++ V D
Sbjct: 48 RSDLSFQLRTNVSAGLLLY--FDDGGI---CDFLCLSLADGHVQLRFSI---DCAETAIVSDKKVNDGGWHFLMLSRNRLRTTLVLDGEAKPGEVRPQRQHMNIVSDLFVGGVP-SDIRSGALTLGSVRDMSAFAGYLLDIKYGNTEPRL--------LGSHGARLDLE----GLCTENPCENGGACLLLDGEPTCDCTATGYVGKFCSEDVNDIPGLAHLMIDDQGRSKAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTRQRNGLILHTGK----SADYVNLALKGGAVSLVINLGSGAFEAIVEPTNDKFN------DNEWHEVKVTRNLRQVTISVD-GILTTTGYTQEDYTMLGSDDFFYVGGS----PSTADLPGSPVSNN--------------FMGCLKEVVYKNNDIRLELSRLARIGDTKMKIYGDVVFKCENVATLDPISFESPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQDRKDIRSQKNTKVDFFAVELLDGHLYLLLDMGSGTIKVKATNKKANDGEWCHVDIQRD-GRSGTISVNTKRTPFTASGESEI------LDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGR--------SKNIRQLAEAQNAAGVKSSCSRLSGKQ---CDSYPCKNNAACRDGWNRFVCDCTGTGHWGRTCEREASILSY-DGGMYMKIIMPVVMHTEAEDVSLRFKSQ-RAYGLLVATTSRDSADTLRLELDGGKVKLMVNLDCIRINCNSSKGPETLYAGQKLN--DNEWHTVRVV--RRGKTLKLTVDDDVAEGTMVGD 808
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Match: Nrxn1 (neurexin I [Source:MGI Symbol;Acc:MGI:1096391]) HSP 1 Score: 331.643 bits (849), Expect = 2.699e-92 Identity = 345/1526 (22.61%), Postives = 608/1526 (39.84%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L ++ K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLYIDRAEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1439 HSP 2 Score: 53.5286 bits (127), Expect = 3.294e-6 Identity = 60/242 (24.79%), Postives = 92/242 (38.02%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QALPVDGGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Match: Nrxn1 (neurexin I [Source:MGI Symbol;Acc:MGI:1096391]) HSP 1 Score: 331.257 bits (848), Expect = 3.123e-92 Identity = 350/1544 (22.67%), Postives = 607/1544 (39.31%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEF-ASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L ++ K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + AS E + P + + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLYIDRAEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1458 HSP 2 Score: 53.9138 bits (128), Expect = 2.437e-6 Identity = 60/242 (24.79%), Postives = 92/242 (38.02%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QALPVDGGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Match: Nrxn1 (neurexin I [Source:MGI Symbol;Acc:MGI:1096391]) HSP 1 Score: 331.257 bits (848), Expect = 3.366e-92 Identity = 348/1543 (22.55%), Postives = 610/1543 (39.53%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L ++ K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLYIDRAEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1457 HSP 2 Score: 53.5286 bits (127), Expect = 2.651e-6 Identity = 60/242 (24.79%), Postives = 92/242 (38.02%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QALPVDGGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Match: Nrxn1 (neurexin I [Source:MGI Symbol;Acc:MGI:1096391]) HSP 1 Score: 330.102 bits (845), Expect = 7.470e-92 Identity = 348/1547 (22.50%), Postives = 609/1547 (39.37%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L ++ K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLYIDRAEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1461 HSP 2 Score: 53.5286 bits (127), Expect = 2.652e-6 Identity = 60/242 (24.79%), Postives = 92/242 (38.02%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QALPVDGGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Match: Nrxn1 (neurexin I [Source:MGI Symbol;Acc:MGI:1096391]) HSP 1 Score: 323.553 bits (828), Expect = 1.190e-89 Identity = 349/1555 (22.44%), Postives = 612/1555 (39.36%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L ++ K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLYIDRAEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVV-AFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1469 HSP 2 Score: 53.5286 bits (127), Expect = 3.222e-6 Identity = 60/242 (24.79%), Postives = 92/242 (38.02%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS------CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + E DE P N + C C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSS---------QALPVDGGEVKLDDE--PPNSGGG-SPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Match: sp|Q9ULB1|NRX1A_HUMAN (Neurexin-1 OS=Homo sapiens OX=9606 GN=NRXN1 PE=1 SV=1) HSP 1 Score: 329.331 bits (843), Expect = 8.123e-91 Identity = 347/1542 (22.50%), Postives = 608/1542 (39.43%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSE--------------------EEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
+SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE + P +Q + I+VA +CP ++ E + G+ P A + +P+ P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 54 MSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQVLPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALLKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECP--SDDEDIDPCEPSSGGLANPTRAGGR---------------------EPY----------------------PGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1439
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Match: sp|Q9Y4C0|NRX3A_HUMAN (Neurexin-3 OS=Homo sapiens OX=9606 GN=NRXN3 PE=1 SV=4) HSP 1 Score: 317.005 bits (811), Expect = 1.745e-86 Identity = 310/1324 (23.41%), Postives = 545/1324 (41.16%), Query Frame = 2
Query: 140 NTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTC------------YFDSNFCRYCSS-----------------------SKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKR---MENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN 3910
+T S LSFQ K + GL+ Y +D F+ L L+ +V+L F D + +K+ + D S WH +M++ + +L + + + + + + D +F GG+P ++ A P F G I ++ L +Q DA C D + CS+ S++ + TF + + Y + I + I FKT Q N + + G ++++ ++DG ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + + G++ C + + P++F Y+ + R S F+T + + LI + +P +K +T DF+++E+ D LY + + S + ++G +++ + + I ++ S ++ EG +Y+G L + + L + +W+ +L + GCI L ID + L + ++ +G K+S S C + PC N +C+ W++ CDCT T + G TC +EA I ++G +M+I P +E E+ F S+ GL+++T ++ S T +LE + G + +++N +G + + D++WH++++ RR K+LK+ +DD+ E GT + D + N + KR + F+G++ ++NG Y +L K EL A N++ + F + SYL + + + L FQ KT P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S THS D++ V G N + G +++ G Q + + + S+ GFQGC+AS +N + DL+ +A + ++ C C DSC+ G C Q W ++CDCS TS+SG +C D T F K ++Y + + S ++LA GF T T K L+ I L L + I + G I V + T S E R V DG YH+VRF ++ ATL++D+ H P G Q T+ + + +G + FQG +SGL + + +L+ EN
Sbjct: 46 STRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVD-GRVQL---RFSMDCAETAVLSNKQ----------VNDSS--------WHFLMVSRDRLRTVLMLDGEGQSGEL----QPQRPYMDVVSD-LFLGGVPTDIRPSA--LTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQM--DAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGK-----------SADYVNLALKDGAVSLVINLGSG---AFEAIVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFK-CENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNA--AGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLE--LDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAE-------------------------GTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIAD-PVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKV-------DTKVVTQVINGAKNLDLKGDLYMAGLA--QGMYSNLPKLVASRDGFQGCLASVDLNGRL--------PDLINDALHRSGQIERGC----EGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFST-TVKDGILVRIDSAPGLGDFLQLHI----EQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTG-RQLTIFNTQAQIAIGGKD--KGRLFQGQLSGLYYDGLKVLNMAAEN 1250
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Match: sp|Q9CS84|NRX1A_MOUSE (Neurexin-1 OS=Mus musculus OX=10090 GN=Nrxn1 PE=1 SV=3) HSP 1 Score: 308.145 bits (788), Expect = 8.315e-84 Identity = 301/1312 (22.94%), Postives = 531/1312 (40.47%), Query Frame = 2
Query: 755 KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIK---------------EFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 279 KEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1476 HSP 2 Score: 138.272 bits (347), Expect = 2.717e-31 Identity = 187/873 (21.42%), Postives = 345/873 (39.52%), Query Frame = 2
Query: 1565 IEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDK-ENYVLNISTNYHDIEFEGSLYIGSLD-DTKILSVSHHVWSGILGTYFSGCIF--------SLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN-------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPL-LTIE---IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
I R L S + + ++++ V++G H++ + + + +D+ E + + + D+ L++G L + + ++ + S F G I +L +D ++LD NS S C+ EE VC N G+C + DQ CDC++T F G C+ KE IA F G ++ N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R NL+ + N L + I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK+ P + I + + NV I F + +S++ +PK N + F +T +P+GL+LF G+ D+ +EM++G L+++ + GSG + + +NDG W+ V F+ DG+ + VNT + G +++LGG EN++ + F E T G+ GCI +++ KD+ + E V +C + C + C G C W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ S L L ++ +K+ + I++ ++ G + N+ D +H VR + + L +DD G I+ + + ++ V S +F G + LT N +A +D K
Sbjct: 82 ILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGGEVKLDDE-PPNSGGGSPCEAGEEGEG-GVCLNG----GVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTR---NLRQHSGIGHAMVNK-LHCSV-TISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVD------------FQRDGR----SGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQ--------SKDIRQMAEIQSTAGVKPSC---SKETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSY-DGSMFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLFAG-YNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS-------NFIGHLQSLTFNGMAYIDLCK 891
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Match: sp|A1XQX0|NR1AA_DANRE (Neurexin-1a OS=Danio rerio OX=7955 GN=nrxn1a PE=2 SV=1) HSP 1 Score: 305.449 bits (781), Expect = 4.177e-83 Identity = 274/1137 (24.10%), Postives = 479/1137 (42.13%), Query Frame = 2
Query: 740 SKKCTKYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIK---------------EFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQ-----------PSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-ID----------------------------QNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN 3910
K+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + +G + C + + PV+F ++ + + S F+T + + L+ + P S K + D F++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + GC+ L +D + + + ++ G K S C + PC N G C+ W++ CDC+ T + G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T +Q S T +LE + G + + +N +G + + +N D++WH++++ RR K+LK+ +DD + I G + F N V I+ + F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L FQ KT P GL+L+ +G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG ++ + P+ SK GFQGC+AS +N + L D L A + V+ C C DSCS G C Q W +SCDCS TS+ GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G ID Q T+ + + +G E S+ FQG +SGL N + +L+ E
Sbjct: 254 GKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFK-CENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVD--FFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVDFQRDGRSGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQSKDIRRIAEAQRAV--GVKPSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIQLPVVMHTEAEDVSLRFRSQRAYGVLMATTSQNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFSGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQL---EFHN-----------VETGIVTEKRYMPAVPSNFIGHLQGLSFNGMSYIDLCKNGDIDYCELNAMIGYRSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFFQFKTTSPDGLILYNRGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLYVGGVAKDMY-----KDLPKLVHSKEGFQGCLASVDLNGRLPD----LQSDALSTAGQ---VERGC----EGPSTTCQEDSCSNQGVCLQQWEGFSCDCSMTSYGGPLCNDPGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----ERGNIKVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPSGNIDNERLAIARQRIPYRLGRVVDDWLLDKGRQLTIFNSQTTIKIGGWEKGSR-PFQGQLSGLYYNGLKVLNMAAEG 1304 HSP 2 Score: 145.591 bits (366), Expect = 1.907e-33 Identity = 189/922 (20.50%), Postives = 372/922 (40.35%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRR-RKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIE-----IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT + L+ Y +G DF + I + L + + V S+ V++ H + L +++D+E + + + D+ L++G + ++ SV+ + S + + G I +L ++ S +LI + S C+ ++C N G+C I D+ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R R++ + + N L + I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK P + + + + NV + F + +S++ + K + + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G K++LGG E+++ + F E T G+ GC+ +++ KD+ + A + V P + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ +Q+ + L +E +++ + I++ T+ G + + N+ D +H VR + + L +DDL G ++ V ++ M V S +F G + GL+ N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSAHGLLVY--FDDEGF---CDFLELLIHNGRLSLRFSIFCAEPATVFSDTAVNDSRWHAVTLRRNFKNTTLVVDEEIKWVEVKSKRRDMTVFSHLFLGGIP-PELRSVALRLTSSAIKDEVPYKGWITNLRVNGSE---PVLIGSDGVNSDICEAD------HICLNG----GVCSIVNDEPICDCSETGFQGKDCSEEEAYVGGLAHLMMGDQGKRKEREEYMATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQHSGIG-----HAMVNKLHCSV-TISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKLGDPKMKVSGVVAFKCENVATLDPVTFETPESFITLDKWSAKKAGSISFDFRTTEPNGLLLFSHGKPKPQQQKDPKSPKTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSIRTPYNAPGESEILDLDDKLYLGGLPEDRAGLIFPTEVWTALLNYGYVGCVRDLFMDGQ--------SKDIRRIAEAQRAVGVK-PSCSKEPPKQCLSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGVLMATT-SQNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFSGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNVETGIVTEKRYMPAVPS-------NFIGHLQGLSFNGMSYIDLCK 873
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Match: sp|Q63372|NRX1A_RAT (Neurexin-1 OS=Rattus norvegicus OX=10116 GN=Nrxn1 PE=1 SV=3) HSP 1 Score: 305.449 bits (781), Expect = 5.950e-83 Identity = 300/1312 (22.87%), Postives = 531/1312 (40.47%), Query Frame = 2
Query: 755 KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI---------------KEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASR----STNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + +K+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G + N VVDE L+ I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + + S ++ + P++ + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 295 KEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVNKLHCSVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSRETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLDCIRINCNSSKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITHKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSE--------------------MSTSIMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1492 HSP 2 Score: 138.272 bits (347), Expect = 3.108e-31 Identity = 187/889 (21.03%), Postives = 347/889 (39.03%), Query Frame = 2
Query: 1565 IEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDK-ENYVLNISTNYHDIEFEGSLYIGSLD-DTKILSVSHHVWSGILGTYFSGCIF--------SLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN--------------------------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN-------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFG---------KMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPL-LTIE---IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
I R L S + + ++++ V++G H++ + + + +D+ E + + + D+ L++G L + + ++ + S F G I +L +D S ++LD NS S C+ +E VC N G+C + DQ CDC++T F G C+ KE IA F G ++ N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R NL+ + N L + I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK+ P + I + + NV I F + +S++ +PK N + F +T +P+GL+LF G+ D+ +EM++G L+++ + GSG + + +NDG W+ V F+ DG+ + VNT + G +++LGG EN++ + F E T G+ GCI +++ KD+ + E V +C + C + C G C W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + L++ S L L ++ +K+ + I++ ++ G + + N+ D +H VR + + L +DD G I+ + + ++ V S +F G + LT N +A +D K
Sbjct: 82 ILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKWVEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDGSEVKLDEE-PPNSGGGSPCEAGDEGDG-GVCLNG----GVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAHLMMGDQGKSKEDNNVEGLAHLMMGDQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTR---NLRQHSGIGHAMVNK-LHCSV-TISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFKCENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVD------------FQRDGR----SGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQ--------SKDIRQMAEIQSTAGVKPSC---SRETAKPCLSNPCKNNGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSY-DGSMFMKIQLPVVMHTEAEDVSLRFRSQ-RAYGILMATTSRDSADTLRLELDAGRVKLTVNLDCIRINCNSSKGPETLF-AGYNLNDNEWHTVRVVRRGKSLKLTVDDQQAMTGQMAGDHTRLEFHNIETGIITERRYLSSVPS-------NFIGHLQSLTFNGMAYIDLCK 907 HSP 3 Score: 55.0694 bits (131), Expect = 7.551e-6 Identity = 57/240 (23.75%), Postives = 92/240 (38.33%), Query Frame = 2
Query: 2738 PKVNIFGDFRLEFQMKTLQPSGLLLFLQGES-NDYLILEMV-NGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLE--NQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDS----CSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKH 3433
PK N + + FQ+KT GL+L+ E D+L L + G L + ++ + +NDG WHSV+I R T + R + K V V + + F + +GG + + + R + F+G I VN+S + L + +DE P++ + C GG C+ + CDCS T F G C + + H
Sbjct: 44 PKWNACCESEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPATLLADTPVNDGAWHSVRIRRQFRNTTLYIDRAEAKW------VEVKSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQA----------LPVDGSEVKLDEEPPNSGGGSPCEAGDEGDGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQEDNNVEGLAH 267
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Match: A0A2T7PG26 (Uncharacterized protein OS=Pomacea canaliculata OX=400727 GN=C0Q70_07803 PE=4 SV=1) HSP 1 Score: 377.481 bits (968), Expect = 3.218e-104 Identity = 325/1307 (24.87%), Postives = 598/1307 (45.75%), Query Frame = 2
Query: 836 SINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDD-FQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFK--THKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT-KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQL--DLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWID-----------------DNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQ-----FFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDV-STTAQFVKHPSYLVYKYSIIKKH--SINQ--LAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNS--FQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCG---GAFMLIALSCLI---------YRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
SI+ F+TK + LFY G++ ++++ I DG + I+ + S R+ + D+ WH V ++ +I + +D +Q++ N +L + + A + + LP + FRGCM+++ ++V L++ E+ + G + D C E+ +P++FT YL + S + SL+F+ T + ++ Y + G + D +++E+ D L+ I + S S V++G H + + I +D + + ++ + +GS +IG + T + + + +W+G LG + GC+ + +D + L I+ + ++ C+ E C ++PC ++G C W++ +CDC T F + C A F+G QF+++ P ++ E+ L F++ PNGL+ T ++ + DK+E+++++GSI++ ++ G G+K + DD+WH+ +KRR + +++ ID + + FL P + +L T+I +++L + ++G V + +N+ F+G M FI+N +F++A+ IE+TA L + + F ST +Y V+P++ I F + FQ+KT + GLL++ G D+ +EM G L+ +YN G+G +R + + + L+D WH V+++R ++T+ RVD K D + ++F+ G +++GG + T + P+ ++ GF GCI S Y+N ++ ++ ++AN H E+ D + C DSC+ GG+C Q W +SCDC TSFSGP C+ V STT +F P Y + K++ ++ S N+ LA GF+ TR ++ I + + + +E+ + G I Y T + E V DG YH+VRF + +T+++D+L + +P G +T ++ + I G E + S FQG ISGL +N I ILD ++ + I L +V + Q + P+N T++ I CP E + I+ P V K + + ++ + N P + +Q T D ++ + PK E + K + N L + S G G + IA+S L+ Y+ ++DEG+Y V E + + ++ N +LL+ ++ +K+ + KEWYV
Sbjct: 280 SISLDFRTKHPDGLLFYTGNV-----------KDYLNIAIRDGAIILAIN----LGSGSLEREIRPSG--PRFDDNLWHQVVVRREAREISLEVDGIYQEKGSTTGNFKLLSSKALYVAGSPD------TANLPGSRVNANFRGCMRKVRYRADSVELDLTELARAEHALLKVIGGVIFDKCQELVDSRPITFTTPESYL-TIPVWSAGPERGSLAFQFQTVEQHGVLLYSTGAASG---NPDVFALELLDGYLHLVINMGSEPIRLKASRQPVTDGSPHMVYFEYAANRGYISVDGQKETFSTFSHLDRFDLQGSFFIGGISKTAEEIPLPTEMWAGTLGYGYVGCLQDMVVDGGRVDLVRAAQIQGVAGVAEYCQAMEPH-----CTSRPCMHQGQCTEGWNRFTCDCRATGFIDSVCQTAAATLRFDGKQFVKVTVPEESHTQAEDISLRFRTMHPNGLLFMTTSERA--EDKMELYLKSGSIFLGVDVGSGHKVLSVGHSLNDDRWHTAYIKRRAQTVELKIDVQRPVTGRHSPCDSFVFQSLHLTKTFLCNRAPPCDLAFL---------TEISRRAAELEFRRV-NIGDVLQDDNKSNAFSGFIGSMQQFIFNRNQFFDMARSE---KIEVTAKLSTNGHVMHDPVTFKSTDAYAVLPRLQIHDKFSISFQLKTTETDGLLMYNPGRGQDFFAMEMTGGFLYYVYNMGAGTQRIRANVNEKLSDNKWHEVQLLR--TETYKQLLRVDDKT--PTVDDLSGSSAIHFDLQGHLYIGGVRK-----TMYHTLPKKVEARFGFMGCIDSLYLNGYMA--------NIHRDANPIH---ESVVDGCQAPASQCQNDSCANGGRCVQQWNSFSCDCDMTSFSGPTCQAVESTTYRF--GPGYGLIKFAHPAENLPSTNRENLALGFK--TRSSDAVLVRIDSATYDDYIELEL----NKGNIVAVYNMGTMDYPIGEMFDKVNDGKYHVVRFTRSGPNSTIQVDNLMMQTKMPRGQQAHTFNNQAFVYIGGKQEKNKTVSRPFQGTISGLVLNGIKILDLARQG-DKRISLEGNVTHQIVHSIS--------IQKQTTPQNGVTDEI---IFSGGGPCPYDDEDDCTATGSGTDDDIITPSVIIKTTPPPPTTTTS--DKRLCKEENCP--HSASELEQPTEDIYVSTPE-QPKEEVSEKPTGDTNKTLSSGGSSGLNLGLIIGIAVSVLVAVVILCIALYKFRSRDEGTYKVDESQ---------NFTSLDSKKSQQGNGTLLSSSDTGKRGGKKK--DVKEWYV 1483 HSP 2 Score: 117.472 bits (293), Expect = 2.050e-22 Identity = 126/502 (25.10%), Postives = 208/502 (41.43%), Query Frame = 2
Query: 1991 PC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAII--AEFNGYQFMRIKFPNTYKSEVEN---FYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGN--KKFKTLENCFDDK-WHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGR----NYFELAKKLSPLNIELTASL--QPANVMRQFAINFHSTKSYLVIPKVNIFGDFR--LEFQMKTLQPSGLLLFLQGESN---DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVI--LYKDLLKEANEKHY--VDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQF 3424
PC N G+C CDC +T F G C+ E I A F G Q+ V N L F++K P+GL+ T N D L I +++G+I + +N G G+ ++ + FDD WH + ++R + + + +D Y E + + ++ K L + + D ++ L + + N F G M Y + ELA+ L + + + ++ I F + +SYL IP V G R L FQ +T++ G+LL+ G ++ D LE+++G LH++ N GS R + + DG H V ++ + VDG+ + F+H + L G I E P + G + YV D V+ DL++ A + V E C E +C+ C G+CT+ W +++CDC +T F C+ + T +F
Sbjct: 218 PCLNGGVCLTTNSGLVCDCARTEFKGERCDLEKIPSDATFFGAQYFTYNLSGQGDGLVSNRDSISLDFRTKHPDGLLFYTGN----VKDYLNIAIRDGAIILAINLGSGSLEREIRPSGPRFDDNLWHQVVVRREAREISLEVDGIYQEKGS-TTGNFKLLSSKALYVAGSPD--------TANLPGSRV----------NANFRGCMRKVRYRADSVELDLTELARAEHALLKVIGGVIFDKCQELVDSRPITFTTPESYLTIP-VWSAGPERGSLAFQFQTVEQHGVLLYSTGAASGNPDVFALELLDGYLHLVINMGSEPIRLKASRQPVTDGSPHMVYFEYAANRGY---ISVDGQKETFS----------TFSHLDRFDLQGSFFIGGISKTAEEIPLPTEMWAGTLGYGYVG--CLQDMVVDGGRVDLVRAAQIQGVAGVAEYC----QAMEPHCTSRPCMHQGQCTEGWNRFTCDCRATGFIDSVCQTAAATLRF 676
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Match: V4AS84 (Uncharacterized protein OS=Lottia gigantea OX=225164 GN=LOTGIDRAFT_141333 PE=4 SV=1) HSP 1 Score: 356.295 bits (913), Expect = 1.864e-99 Identity = 314/1153 (27.23%), Postives = 536/1153 (46.49%), Query Frame = 2
Query: 1229 LPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDY--LQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLD--KENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSG----CKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF---DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGG---LNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHY-VDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSS---KNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNEN---TIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
LP S F+GCM+++ ++V L++ ++ G++ + C E+ P++F + L ++ + ++++A + F+T + + +I Y G+ T TDF++IE+ D LY + L S S V++G H + L ++ P I LD KE Y + ++ ++ G L++G + +D ++ +W+G+LG + GC+ L I+ + ++DL+ ++ G C+ E C + PC ++G+C W++ CDC T F + C + F+G QF+++ P +E E+ L F++ PNGL+ T + TTD +E+++++GSI + ++ + F++L DD+WH++ +KRR + +++ ID + L D + + + D G +++D +S +G E+ F+G M FI+N +FELAK NI++TA + + + + F S +Y +P ++ + F L FQ KT + SGL+LF G+ D+ +E+ G L+ IYN G+G +R I+ LN+ WH V+++R + H R+ DD+ V N GG L+F+ G + +GG + T + P+ S+ GF GC+ S +N + +L+KEA+ H + E C C +DSC G+C Q W Y CDC STS+SG C++ ST+ +F L + Y ++ + LA GF+T ++ A L+ I S + +E+++VN G I V Y T H E V DG YH++RF + +T+++DDL + P G Q V + + VG + F+G ISGL +N I ILD L EN +S I + LV +F D+ L + P+ P K R+ + + T EK Q K V + F HS ++ S PF L PK +N ++ +NI LI + G L+ L +Y+ ++DEG+Y V E + + + N +LL + ++ K+K + KEWYV
Sbjct: 18 LPGSRVKSNFKGCMRKVQYQADSVNLDLTDLAKTSHGLISVVGEVLFNRCQELVESHPITFLTPKSFITLPSWDV-TLKRASIAFQFQTTEPNGVILYN----SGLGTYTDFFAIELLDGHLYLVVDLGSGTIKVKASKIPVNDGKPHEVYLDYQGPQGYITLDGTKEPYSSTVESDL--LQLGGKLFVGGINEDVDSSTLPKEMWAGMLGHGYVGCLQDLVINGN--KMDLVAAAALQLTEGIAEYCRRMEPQ-----CLSYPCMHQGVCVEGWNRFVCDCRATGFIDDVCQTASATLRFDGTQFVKVSMPEESLTEAEDISLRFRTMHPNGLLFMTTS--VKTTDIMELYLESGSIKLNVDLIILDILFQSLTVGHVLNDDRWHTVFIKRRAQTIEIAID-GHRPVTGELPGDAEELEFRNI------DVGHEMKDENS---------VG-----EHSGFIGSMQQFIFNKNYFFELAKSGQIENIDVTAKFSSDDYVVRDPVTFKSASAYATLPTLHAYKKFSLSFQFKTTEESGLVLFNSGQGQDFFCIELHGGYLYYIYNMGAGAQRIMINSKDKLNNNKWHEVRLLR--PELHKQLIRI----DDNTPTVD-NLGGSQALHFDLEGSLFVGGVRK-----TMYHSLPKIITSRHGFLGCLGSLDLNGYLP--------NLVKEADTIHQSIVEGC----KGPTTQCQVDSCGNRGRCVQQWNSYVCDCDSTSYSGETCKEESTSYRFGPGEGLLTFSYPAYQRPDTVGDNLALGFKTFSKD-AVLVRI---DSGNFDDYVEMELVN--GNIFVVYNMGTTDHPIGEIFKQVNDGKYHVIRFTRSGPNSTIQIDDLMMQTKNPKG-QQLGVFNNQAYVYVGGKKTEDGMIARPFEGTISGLVMNGIHILD-LAENNDSRI--TKEKMMKLVHSFY----DEVLLKPTSVPEPP----KKERV---KSKSTRQTSEEKNQTTP---KLGVTDDIIFSGAGAG-CHSDDE-DDCTSVGGATPFYPL--------------QSSFPPKGDNSKESVGGVATLNIGLIVGIAAGVLVALLILIFALYKFRSRDEGTYKVDESQ----------NFSYLESKKPQGNGALLGANDSNKRGKKK---DVKEWYV 1056 HSP 2 Score: 108.227 bits (269), Expect = 1.001e-19 Identity = 135/600 (22.50%), Postives = 248/600 (41.33%), Query Frame = 2
Query: 674 QFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMV-TKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHD---------IEFEGSLYIGSLDDT------KILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKK----NSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFN-GYQFMRIKFPNTYKSEV--ENFYLMFKSKLPNGLILSTQNQFSGT-TDKLEIFMQNGSIYILLNFGRGNKKF-KTLENCFDDKWHSIKMKRRRKNLKVWIDD 2398
+F D T + D + C+ S++ L FD + + P + ++E I+ +F+T N LF S + T + +Y+E G + +VD F ++ DD+WH V IK I I +D + ++ + ++F + + + ++ S F G M++ ++N E+ + ++ N K +SD + PV+F S Y + + +K S FKT + L+ + + DF+ IE+ LY+ + + ++M N S L+N H E+ ++R L K+ ++ +T D + EGSL++G + T KI++ H F GC+ SL ++ L L+K+ + SI GCK ++ C N+ G C +W+ CDC T+++G TC +E+ F G + +P + + +N L FK+ + +++ SG D +E+ + NG+I+++ N G + + + D K+H I+ R N + IDD
Sbjct: 280 RFVCDCRATGFID-DVCQTASAT--------LRFDGTQFVKVSMPEESLTEA-EDISLRFRTMHPNGLLFMTTS---------VKTTDIMELYLESGSIKL------NVDLIILDILFQSLTVGHVLNDDRWHTVFIKRRAQTIEIAIDG----HRPVTGELPGDAEELEFRNIDVGHEMKDENSVGEH---SGFIGSMQQFIFNKN----YFFELAKSGQIENIDVTAKFSSD---DYVVRDPVTFKSASAYATLPTLHAYKKFSLSFQFKTTEESGLVLFNSGQGQ------DFFCIELHGGYLYYIYNMGAGA-QRIMIN---SKDKLNNNKWH-EVRLLRPELHKQLIRIDDNTPTVDNLGGSQALHFDLEGSLFVGGVRKTMYHSLPKIITSRHG---------FLGCLGSLDLNG---YLPNLVKEADTIHQSIVEGCKGPTTQCQVDSCGNR----GRCVQQWNSYVCDCDSTSYSGETCKEESTSYRFGPGEGLLTFSYPAYQRPDTVGDNLALGFKTFSKDAVLVRID---SGNFDDYVEMELVNGNIFVVYNMGTTDHPIGEIFKQVNDGKYHVIRFTRSGPNSTIQIDD 810
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Match: A0A341C607 (neurexin-1 isoform X16 OS=Neophocaena asiaeorientalis asiaeorientalis OX=1706337 GN=NRXN1 PE=4 SV=1) HSP 1 Score: 359.377 bits (921), Expect = 2.712e-98 Identity = 349/1488 (23.45%), Postives = 605/1488 (40.66%), Query Frame = 2
Query: 149 SSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT--KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEF-ASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
S +SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N G+G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + AS E + P + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALLVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFVSLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSRETAKPCLSNPCKNSGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPLVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLGKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS--------------------IMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1399
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Match: A0A2Y9R6E5 (neurexin-1 isoform X9 OS=Trichechus manatus latirostris OX=127582 GN=LOC101342964 PE=4 SV=1) HSP 1 Score: 358.992 bits (920), Expect = 3.234e-98 Identity = 350/1488 (23.52%), Postives = 604/1488 (40.59%), Query Frame = 2
Query: 149 SSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQF-----QSDAMNTCY----------FDSNFCRY--------CSSS----KKCT--KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEF-ASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
S ++FQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L L ++ S + C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N GIC+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N G+G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + AS E + P + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 52 SEMTFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALLLDSGEVKLDDEPPHSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFISLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEIQST--AGVKPSCSRETAKPCLSNPCKNNGICRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPVVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLGKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAILVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAVQSEMSTS--------------------IMETTTTLATSTARRG---------KPPTKEPVSQTTDDILVASAECPSDDEDIDPCEPSSANPTRAGGRESYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1399
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Match: A0A2Y9SE17 (neurexin-1 isoform X16 OS=Physeter macrocephalus OX=9755 GN=NRXN1 PE=4 SV=1) HSP 1 Score: 358.607 bits (919), Expect = 4.152e-98 Identity = 349/1488 (23.45%), Postives = 605/1488 (40.66%), Query Frame = 2
Query: 149 SSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEK-VNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNT-----CY----------FDSNFCRY--------CSSS----KKCT--KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDN--ETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEF-ASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
S +SFQ+K + GL+ Y +D F+ L L +++L +F + T + D DG WH++ I ++ L +Q K V + KR D + +F GGLP +L+ A S F G I VR+ L + ++ + N+ C + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + C + + P++F ++ + + S F+T + + LI + Q +K DF++IE+ D LY + + S V++G +++ + I ++ ++ + LY+G L + K L VW+ +L + GCI L ID + + + S+ +G K S + C + PC N G+C+ W++ CDC+ T + G +C +EA + ++G FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N G+G + N D++WH++++ RR K+LK+ +DD + + G + T ++ + + II + F+G++ +NG Y +L K EL A N++ + F + SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH +++ G+G K S + LND WH+V I R S H+ D++ + G N + +++GG + T+ + + +K GFQGC+AS +N + DL+ +A + + C DSCS G C Q W +SCDCS TSFSGP C D TT F K + YK+ + S ++LA GF T +K A L+ + + L L + I G I V++ T + ES + DG YH+VRF + ATL++D P G Q T+ + + I+G E FQG +SGL N + +L+ EN + ++ N VP+ S + QSE I E +G KP T+E S+T + AS E + P + + + P + I+ + + ++ + +LI L + Y+ +DEGSY+V E R
Sbjct: 52 SEMSFQLKTRSARGLVLYFDDEGFCDFLELILTRGGRLQLSFSIFCAEPA-----------------TLLADTPVNDG---AWHSVRIRRQFRNTTLFIDQVEAKWVEV-----KSKRRDMTVFSGLFVGGLPPELRAAALKLTLASVREREPFKGWIRDVRVNSSQALPVDSGEVKLDDEPPNSGGGSPCEAGEEGEGGVCLNGGVCSVVDDQAVCDCSRTGFRGKDCSQGKEEYIATFKGSEYFCYDLSQNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGVVAFK-CENVATLDPITFETPESFVSLPKWNAKKTGSISFDFRTTEPNGLILFSHGKPRHQKDAKHPQMIKVDFFAIEMLDGHLYLLLDMGSGTIKIKALQKKVNDGEWYHVDFQRDGRSGTISVNTLRTPYTAPGESEILDLDDELYLGGLPENKAGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDIRQMAEVQST--AGVKPSCSRETAKPCLSNPCKNSGMCRDGWNRYVCDCSGTGYLGRSCEREATVLSYDGSMFMKIQLPLVMHTEAEDVSLRFRSQRAYGILMATTSRDSADTLRLE--LDAGRVKLTVNLGKGPETLFAGYNLNDNEWHTVRVVRRGKSLKLTVDD------------------QQAMTGQMAGDHTRLEFHN---IETGIITERRYLSSVPSNFIGHLQSLTFNGMAYIDLCKNGDIDYCELNARFGFRNIIAD-PVTFKTKSSYVALATLQAYTSMHLFFQFKTTSLDGLILYNSGDGNDFIVVELVKGYLHYVFDLGNGANLIKGSSNKPLNDNQWHNVMISRDTSNLHTVKI-------DTKITTQITAGARNLDLKSDLYIGGVAKE----TYKSLPKLVHAKEGFQGCLASVDLNGRL--------PDLISDA---LFCNGQIERGCEGPSTTCQEDSCSNQGVCLQQWDGFSCDCSMTSFSGPLCNDPGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFST-VQKEAVLVRVDSSSGLGDYLELHIH----QGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAG-RQLTIFNSQATIIIGGKE--QGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTS--------------------IMETTTTLATSTARRG---------KPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSANPTRAGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAM-YKYRNRDEGSYHVDESR 1399
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Match: ENSAMXT00000000309.2 (pep primary_assembly:Astyanax_mexicanus-2.0:21:10525143:11115194:1 gene:ENSAMXG00000000283.2 transcript:ENSAMXT00000000309.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 317.39 bits (812), Expect = 6.980e-88 Identity = 315/1368 (23.03%), Postives = 560/1368 (40.94%), Query Frame = 2
Query: 92 FIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRY--------CSSS----KKCT------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QP-----SSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDD--------NYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-IDQ--------------NTVVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN 3910
F G P N S +SF +K GL+ Y +D F+ L L+++ K+ L +F + +T D+ D +WH + I + K+ L ++ + + KR D + +F GG+P +L+ A ++ + F+G I+ +++ L + + T + C CS + K C+ K EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + L+ + +P +K + DF++IE+ D LY + + S N V++G +++ + I ++ ++ + +LY+G L + K L VW+ +L F GC+ L ID D+ S ++G K+S + C + PC N G+C+ W++ C+C+ T F G +C ++A I ++G +FM+I+ P +E E+ L F+S+ G++++T ++ S T +LE ++ G + + +N +G + +N D++WH++++ RR KNL++ +DD EF+N ++ I+ K + S + SN F+G++ ++NG Y +L K EL A + +++ + F S SY+ + + + L FQ KT GL+L+ G+ ND++++E+V G LH + + G+G + K + + LND WH+V I R + H+ D++ G N + G +++GG + E P+ +K GFQGC+AS +N + DL+ +A ++ C C DSC+ G C Q W +SCDCS TSF GP C D TT F + + Y + + S ++LA GF T K A LI + + L L + I + G + V + T + E V DG YH+V+F + ATL++DDL P G ID VVDE L+ +G + SFQG +SGL N + + + E
Sbjct: 30 FSGAEGQWAAFPMWNACCESEMSFNMKTKASQGLLVYFDDEGFCDFLEL-LMNNGKLNLRFSIF-----------------CAEPVTVFSDVVVND---SQWHGVTIKRNFKNTTLVVDREVKWAEV-----KSKRRDMTVFSRLFLGGIPPELRTVALRLTSDAAKEQVPFNGWITDLKVNNSVPAILTSGGVDNNACGSETMCLNGGVCSVVNDKPTCDCSETGYQGKDCSEGLAHMMMGDQGKEEYVATFKGSEYFCYDLSQNPIQSSSDEITLSFKTMQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNDWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRVALQGDPKMKIHGVV-AFKCENVATLDPITFETPEAFITLHKWNAKKTGSISFDFRTTEPNGLLLFSHGRPKQQTKEAKSPLTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAINKKVNDGEWNHVDFQRDGRAGTISVNTIRTPYQAPGESEILDLDDNLYLGGLPENKAGLVFPTEVWTALLNYGFVGCVRDLFIDGQ--SKDVRRMAESQKATGVKSSCSKEAPKQCISNPCLNNGVCREGWNRYVCECSGTGFLGRSCERDATILSYDGSKFMKIQLPVAMHTEAEDVTLRFRSQRAYGVLMATTSRDSADTLRLE--LETGRVRLTINLDCIRINCTTSKGPETLFAGQNLNDNEWHTVRVMRRGKNLQLSVDDLQTITGDHTQLEFHN---IETGIVTEKRYL---------------STVPSN---------------FIGHLQSLVFNGMAYIDLCKNGDIDYCELNAMIGFKSIIAD-PVTFKSRSSYISLTTLQAYYSMHLFFQFKTTSSDGLILYNSGDGNDFIVVELVKGYLHYVADLGNGAHLIKGNSNKPLNDNQWHNVMISRDTNNLHTVKI-------DTKVTTQTTMGAKNLDLKGDLYIGGVAKEMY-----KELPKLVHAKEGFQGCLASMDLNGRLP--------DLISDAITCVGQIERGC----EGPSTTCQEDSCANQGVCLQQWEGFSCDCSMTSFGGPLCSDAGTTYIFGRDGGRITYTWPPNDRPSTRADRLALGFSTQL-KDALLIRVDSSSGLGDYLKLHI----EKGNVAVIFNVGTDDINIEEKAKFVNDGKYHVVKFTRSGGNATLQVDDLPVIERYPTGNIDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQTTIQIGGWDRDRSRSFQGQMSGLYYNGLKVFNMAVEG 1275 HSP 2 Score: 145.976 bits (367), Expect = 1.538e-34 Identity = 188/911 (20.64%), Postives = 363/911 (39.85%), Query Frame = 2
Query: 1373 ICMEMFPIKPVSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTY--FSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIK-YLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIY-NGRNYFELAK---KLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN--------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK---------MHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLL----TIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDL----SDRIHVP-DGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+C + + F+G AF + + +++ S + KT S L+ Y +G DF + + + L + V S+ V++ H + + +++D+E + + D+ L++G + ++ +V+ + S F+G I L +++S + ++SG + S +C N G+C + D+ +CDC++T + G C+ KE +A F G ++ N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + + + +D + + D ++G + +G + D VSN+ FMG + +Y N EL++ + P + I + + NV I F + ++++ + K N + F +T +P+GLLLF G D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VNT + G+ ++LGG EN++ + F E T GF GC+ +++ KD+ + E+ + V +C + C + C G C + W +Y C+CS T F G CE +T + ++ + + + F++ R + L++ S L T +++ + I++ T+ G + + N+ D +H VR + L +DDL D + I+ V ++ ++ V S +F G + L N +A +D K
Sbjct: 18 VCTLVDAGASLKFSGAEGQWAAFPMWNACCESEMSFNMKTKASQGLLVY--FDDEGF---CDFLELLMNNGKLNLRFSIFCAEPVTVFSDVVVNDSQWHGVTIKRNFKNTTLVVDREVKWAEVKSKRRDMTVFSRLFLGGIP-PELRTVALRLTSDAAKEQVPFNGWITDLKVNNSVPAI---------LTSGGVDNNACGSETMCLNG----GVCSVVNDKPTCDCSETGYQGKDCSEGLAHMMMGDQGKEEYVATFKGSEYFCYDLSQNPIQSSSDEITLSFKTMQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNDWHDVKVTRNLRQVTISVD-GILTTTGYTQEDYTMLGSDDFFYVGGS----PSTADLPGSPVSNN--------------FMGCLKEVVYKNNDVRLELSRVALQGDPKMKIHGVVAFKCENVATLDPITFETPEAFITLHKWNAKKTGSISFDFRTTEPNGLLLFSHGRPKQQTKEAKSPLTLKVDFFAIEMLDGHLYLLLDMGSGTTKTRAINKKVNDGEWNHVD------------FQRDGRA----GTISVNTIRTPYQAPGESEILDLDDNLYLGGLPENKAGLVFPTEVWTALLNYGFVGCVRDLFIDGQ--------SKDVRRMAESQKATGVKSSC---SKEAPKQCISNPCLNNGVCREGWNRYVCECSGTGFLGRSCERDATILSY-DGSKFMKIQLPVAMHTEAEDVTLRFRSQ-RAYGVLMATTSRDSADTLRLELETGRVRLTINLDCIRINCTTSKGPETLFAGQ-NLNDNEWHTVRVMRRGKNLQLSVDDLQTITGDHTQLEFHNIETGIVTEKRYLSTVPS-------NFIGHLQSLVFNGMAYIDLCK 843 HSP 3 Score: 104.76 bits (260), Expect = 6.232e-22 Identity = 128/565 (22.65%), Postives = 224/565 (39.65%), Query Frame = 2
Query: 1058 DDKWHNVQIKEFRNDIVITLDDFQK--------EFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGL-NSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDT--KILSVSHHVWSGILGTYFSGCIFSLTIDDS-PIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKF---PNTYKS-EVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDD-KWHSIKMKRRRKNLKVWIDD----NYYEFNNFLEMDMPII--GIKYLIIGSAFDNGTDIQDSSSKLV---SNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQ 2674
D++WH V++ ++ +++DD Q EF N+ +T+ ++ +T P + Q + ++ C N ++ E LN+ I + PV+F +S Y+ +++ FKT SD LI Y DF +E+ L++ L N K SN +++ HN+++ + + + + +++ +G LYIG + K L H G F GC+ S+ ++ P + I I GC+ + CANQ G+C +W+ SCDC+ T+F G C+ F G RI + PN S + L F ++L + L++ + SG D L++ ++ G++ ++ N G + + +D K+H +K R N + +DD Y N + I I Y +G D + D +L S I +G R ++ F G M YNG F +A + P NI + S++
Sbjct: 769 DNEWHTVRVMRRGKNLQLSVDDLQTITGDHTQLEFHNIETGIVTEKRYL----STVPSNFIGHLQSLVFNGMAYIDLC--------KNGDIDYCE--------------LNAMIGFKSIIADPVTFKSRSSYISLTTLQAYYSMHLFFQFKTTSSDGLILYNSGDGN------DFIVVELVKGYLHYVADLGNGAHLIKGNSNKPLNDNQWHNVMISRDTNNLHTVKIDTKVTTQTTMGAKNLDLKGDLYIGGVAKEMYKELPKLVHAKEG-----FQGCLASMDLNGRLPDLISDAITCVGQIERGCEGPSTTCQEDSCANQ----GVCLQQWEGFSCDCSMTSFGGPLCSDAGTTYIF-GRDGGRITYTWPPNDRPSTRADRLALGFSTQLKDALLIRVDSS-SGLGDYLKLHIEKGNVAVIFNVGTDDINIEEKAKFVNDGKYHVVKFTRSGGNATLQVDDLPVIERYPTGNIDNERLAIARQRIPYR-LGRVVDEW--LLDKGRQLTIFNSQTTIQIGGWDRDRSRSFQGQMSGLYYNGLKVFNMAVEGDP-NIRIEGSVR 1286
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Match: ENSAMXT00000011949.2 (pep primary_assembly:Astyanax_mexicanus-2.0:6:20986441:21378525:-1 gene:ENSAMXG00000011628.2 transcript:ENSAMXT00000011949.2 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 305.064 bits (780), Expect = 4.816e-84 Identity = 336/1507 (22.30%), Postives = 597/1507 (39.62%), Query Frame = 2
Query: 161 FQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFD-----SNFCRY--------CSSS----KKCT--------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY--------QPSSKKGIHT-DTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEA-NEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQC-PGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPF--EYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDR 4453
F +K + GL+ Y +D F+ L L+ + ++ L +F + T + D + D WH + + + K+ L + + V + KR D + MF GG+P +L+ A S + + G I+ +++ P ++ N C D C CS + K C+ + EY+ TF + Y + I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + PV+F ++ + + S F+T + + L+ + Q KG T DF++IE+ D LY + + S N V++G +++ + I ++ N ++ + LY+G L +D L VW+ +L + G I + + L+ +L +N N G C+ W++ CDC+ T + G +C ++A I ++G +FM+IK P +E E+ L F+S+ G++++T ++ S T +LE + G + + +N +G + +N D++WH++++ RR K+LK+ +DD + I G + + G + V ++ F+G++ +NG +Y +L K EL A + +++ + F S SY+ +P + + L Q KT P GL+L+ +G+ ND++++E+V G +H + + G+G + K + + LND WH+V I R + H+ D++ G N + G + +GG + + P+ SK GFQGC+AS +N + DLL +A V+ C C DSCS G C Q W ++CDCS TSF GP C D TT F + +VY + + S ++LA GF T +K A L+ + + L L ++I + G I+V + T + E+ V DG YHIVRF + ATL++DDL P G Q T+ + + +G E S+ FQG +SGL N + +L+ E PN R + S + + P + T Q + R + P +T+ N Q K + T+ ++ S P E + P + + PK + + ++ A ++ L +Y+ +DEGSY+V E R
Sbjct: 53 FNMKTKSSHGLLVYFDDEGFCDFLEL-LIHNGRISLRFSIFCAEPA-----------------TVLSDTAVND---SRWHAVTVRRNFKNTTLVVDDEIKWVEV-----KSKRRDMTVFSPMFLGGIPPELRSVALRLTSASIKDQVPYKGWITNLKVNDSE-----PAIVSSDGITSNVCEADHVCLNGGVCSIVNDQPICDCSETGFQGKDCSEGLAHLMMADQGMVREEYVATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNAWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDAKMKVSG-IVAFKCENVATLDPVTFETPESFVTLSKWTAKKAGSISFDFRTTEPNGLLLFSHGKPKQQQQKDPKGPKTMKVDFFAIEMLDGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVDFQRDGRSGTISVNSVRTPYNAPGESEILDLDDVLYLGGLPEDRAGLVFPTEVWTALLNYGYVGYIRRIAEAQRAVGSSFLV-----------------ALGKKSNPCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSYDGSKFMKIKLPVVMHTEAEDVSLRFRSQRAYGVLMATTSRNSADTLRLE--LDGGRVRLTVNLDCIRINCTTSKGPETIFAGQNLNDNEWHTVRVVRRGKSLKLMVDD-------LQPSEGQITGDHTQLEFHNIETGIITEKLYMPAVPSN--------------FIGHLQGLGFNGMSYIDLCKNGDIDYCELNAMIGYKSIVAD-PVTFKSRSSYVTLPTLQAYYSMHLFLQFKTTSPDGLILYNRGDGNDFIVVELVKGYMHYVSDLGNGAHLIKGNSNTPLNDNHWHNVMISRDTNNLHTVKI-------DTKITTQTTMGAKNLDLKGDLFVGGVSKEMY-----KDLPKLVHSKEGFQGCLASVDLNGRL--------PDLLSDALTTMGQVERGC----EGPSTTCQEDSCSNQGVCLQQWEGFTCDCSMTSFGGPLCNDAGTTYIFGRDGGLIVYTWPPNDRPSTRADRLAVGFSTQ-QKDAVLVRVDSSSGLGDYLQLQI----EKGNIRVVFNVGTDDINIEETSKFVNDGKYHIVRFTRSGGNATLQVDDLPVIERYPTG-RQLTIFNSQTTIKIGGWERGSR-PFQGQLSGLYYNGLKVLNMAAEGD---------------PNV---RVEGSARLVGDLPSSSITPQSSASATGNRSETSPSLTDI-----------------TTTTASNRQGKQTTTSQDDLLVASAECPSDDEDIDPCDPTSGGLEQCGRGGKKPKKSPEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESR 1392 HSP 2 Score: 132.88 bits (333), Expect = 1.373e-30 Identity = 184/912 (20.18%), Postives = 360/912 (39.47%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILG--TYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN--------------KEAIIAEFNGYQFMRIKF-PNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIY-NGRNYFELAKKL----SPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN---------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK---------MHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPL-LTIE---IKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG---------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT S L+ Y +G DF + I + + + + V+S+ V++ H + + +++D E + + + D+ +++G + ++ SV+ + S + + G I +L ++DS + +SS TS + +VC N G+C I DQ CDC++T F G C+ +E +A F G ++ PN +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y N EL++ + + + + + NV + F + +S++ + K + F +T +P+GLLLF G+ D+ +EM++G L+++ + GSG + + + +NDG W+ V F+ DG+ + VN+ +N G+ ++LGG E+++ + F E T G+ G I + ++ L K++N C G C + W +Y CDCS T + G CE +T + ++ K ++ ++ F++ R + L++ S L L ++ +++ + I++ T+ G + + N+ D +H VR + + L +DDL G I+ + ++ M V S +F G + GL N ++ +D K
Sbjct: 28 MEFTGAEGQWARFPMWNACCESEMSFNMKTKSSHGLLVY--FDDEGF---CDFLELLIHNGRISLRFSIFCAEPATVLSDTAVNDSRWHAVTVRRNFKNTTLVVDDEIKWVEVKSKRRDMTVFSPMFLGGIP-PELRSVALRLTSASIKDQVPYKGWITNLKVNDSEPAI---------VSSDGITSNVCEADHVCLNG----GVCSIVNDQPICDCSETGFQGKDCSEGLAHLMMADQGMVREEYVATFKGSEYFCYDLSPNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNAWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDAKMKVSGIVAFKCENVATLDPVTFETPESFVTLSKWTAKKAGSISFDFRTTEPNGLLLFSHGKPKQQQQKDPKGPKTMKVDFFAIEMLDGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVD------------FQRDGR----SGTISVNSVRTPYNAPGESEILDLDDVLYLGGLPEDRAGLVFPTEVWTALLNYGYVGYIRRIAEAQRAVGSSFLVA--LGKKSN-----------------------PCLNSGTCREGWNRYVCDCSGTGYLGRSCERDATILSY-DGSKFMKIKLPVVMHTEAEDVSLRFRSQ-RAYGVLMATTSRNSADTLRLELDGGRVRLTVNLDCIRINCTTSKGPETIFAGQ-NLNDNEWHTVRVVRRGKSLKLMVDDLQPSEGQITGDHTQLEFHNIETGIITEKLYMPAVPS-------NFIGHLQGLGFNGMSYIDLCK 842
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Match: nrxn3a (neurexin 3 [Source:NCBI gene;Acc:103035103]) HSP 1 Score: 303.138 bits (775), Expect = 4.536e-83 Identity = 303/1339 (22.63%), Postives = 553/1339 (41.30%), Query Frame = 2
Query: 137 VNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAM--------NTCYFDSNFCRYCSSSK--KCTKYEYL---------------------------------TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTL---NIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGS----------IYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVS--TDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILD 3895
+T S LSFQ K D L+ Y +D F+ L ++ K++L + ++T ++ +++ WH + + + +L + ++ + +++ + D +F GGLP+ ++ S ++ P F G +R +++ R +P ++ Q M N C + C C+K EY+ TF + Y + I + I FKT Q N + + G ++++ ++DG ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + +V K+ K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K +T DF+++E+ D +LY + + S + V++G +++ + + I ++ S ++ EG +Y+G L D + L + +W+ +L + GCI L ID + + + + +G K S S C + PC N+G+C+ W++ CDCT T + TC +EA I ++G +M++ P +E E+ L F S+ GL+++T ++ S T +LE+ +GS I I N +G + + D++WH++++ RR K+ K+ +DD+ E G + D + N + +R + F+G++ +NG Y +L K EL A +++ + F + SYL + + + L FQ KT G++LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S H+ D++A V G N + G +++ G N N P+ S+ GF+GC+AS +N + + + ++ E ++ + C DSC+ G C Q W Y+CDCS TS++G +C D TT F K + + + ++ S ++L GF T+ K L+ I L L + I + G I V + T E+ + V DG YH+VRF ++ ATL++D+ + H P G Q T+ + + +G ++ K FQG +SGL N + +L+
Sbjct: 41 ASTRSDLSFQFKTDASTALVLYFDDGGYCDFLQL-MVVEGKLQLQFSIDCAETT-------------------VVSDKRVND--SSWHFVSLGRYNLRTVLGVDGANKADEV----RPQRQYMKIVSD-LFLGGLPQDIR--TSVLTLPTAKDLPPFKG---IIRDLKYGRK--VPTLLSSQKVRMDMEGICTENPCE-NGGICSLVDGEPLCDCSKTEYIGRFCSEEANSIPGLAHMMMADQAKSKAREENVATFRGSEYFCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGK-----------SADYVNLALKDGAVSLVIN---LGSGAFEAIVEPVNGKFN---DNVWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIVDPKM-------KIQGDVVFKCENVATLDPISFETPEAYISLPKWNTKRMGSISFDFRTSEPNGLILFTHGKPQDRKATGSQKNTKVDFFAVELLDGSLYLLLDMGSGTIKVKATQNKVNDGAWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPDNRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIRQIAEAQNG--AGIKPSCNKVSGKQCESYPCKNKGVCKEGWNRFVCDCTGTGYWSRTCEREASILSYDGSMYMKVVMPTVMHTEAEDVSLRFMSQRAYGLLMATTSRDSADTLRLEL---DGSRVKLTVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVIRRGKSYKLTVDDDVAE-------------------------GQMVGDHTRLEFHNIETGVMTERRFVSHIPSSFIGHLQSLKFNGLLYIDLCKNGDIDYCELNARFGMRSIIAD-PVTFKAKSSYLSLATLQAYTSMHLFFQFKTTSADGIILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNLIKGNSDRPLNDNQWHNVVITRDNSNLHTLKI-------DAKAVSQVVNGAKNLDLKGDLYIAGLGPNMY-----NSLPKLVASREGFKGCLASVDLNGRLPDLINDALFRSGQIERGCEVGFIKADL----QGPSTTCQEDSCANMGICIQQWENYTCDCSMTSYTGTQCNDPGTTYIFGKGGGTITFNWPANERPSTRTDRLTVGFSTSL-KDGILVRIDSAPGLGDYLMLHI----EQGKISVTFNIGTVDIIVQENSIPVNDGKYHVVRFTRNGGNATLQVDNWAINEHFPAG-RQLTIFNTQATITIGGND--RKRPFQGQLSGLYYNGLKVLN 1254
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Match: nrxn3a (neurexin 3 [Source:NCBI gene;Acc:103035103]) HSP 1 Score: 301.212 bits (770), Expect = 1.954e-82 Identity = 300/1358 (22.09%), Postives = 553/1358 (40.72%), Query Frame = 2
Query: 137 VNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAM--------NTCYFDSNFCRYCSSSK--KCTKYEYL---------------------------------TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTL---NIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVS--TDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQN-----------------------------TVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILD 3895
+T S LSFQ K D L+ Y +D F+ L ++ K++L + ++T ++ +++ WH + + + +L + ++ + +++ + D +F GGLP+ ++ S ++ P F G +R +++ R +P ++ Q M N C + C C+K EY+ TF + Y + I + I FKT Q N + + G ++++ ++DG ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + +V K+ K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K +T DF+++E+ D +LY + + S + V++G +++ + + I ++ S ++ EG +Y+G L D + L + +W+ +L + GCI L ID + + + + +G K S S C + PC N+G+C+ W++ CDCT T + TC +EA I ++G +M++ P +E E+ L F S+ GL+++T ++ S T +LE + + + +N G+G + + D++WH++++ RR K+ K+ +DD+ E G + D + N + +R + F+G++ +NG Y +L K EL A +++ + F + SYL + + + L FQ KT G++LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S H+ D++A V G N + G +++ G N N P+ S+ GF+GC+AS +N + + + ++ E ++ + C DSC+ G C Q W Y+CDCS TS++G +C D TT F K + + + ++ S ++L GF T+ K L+ I L L + I + G I V + T E+ + V DG YH+VRF ++ ATL++D+ + H P G + N T+ + + +G ++ K FQG +SGL N + +L+
Sbjct: 41 ASTRSDLSFQFKTDASTALVLYFDDGGYCDFLQL-MVVEGKLQLQFSIDCAETT-------------------VVSDKRVND--SSWHFVSLGRYNLRTVLGVDGANKADEV----RPQRQYMKIVSD-LFLGGLPQDIR--TSVLTLPTAKDLPPFKG---IIRDLKYGRK--VPTLLSSQKVRMDMEGICTENPCE-NGGICSLVDGEPLCDCSKTEYIGRFCSEEANSIPGLAHMMMADQAKSKAREENVATFRGSEYFCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGK-----------SADYVNLALKDGAVSLVIN---LGSGAFEAIVEPVNGKFN---DNVWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIVDPKM-------KIQGDVVFKCENVATLDPISFETPEAYISLPKWNTKRMGSISFDFRTSEPNGLILFTHGKPQDRKATGSQKNTKVDFFAVELLDGSLYLLLDMGSGTIKVKATQNKVNDGAWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPDNRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIRQIAEAQNG--AGIKPSCNKVSGKQCESYPCKNKGVCKEGWNRFVCDCTGTGYWSRTCEREASILSYDGSMYMKVVMPTVMHTEAEDVSLRFMSQRAYGLLMATTSRDSADTLRLE--LDGSRVKLTVNLGKGPETLYAGQKLNDNEWHTVRVIRRGKSYKLTVDDDVAE-------------------------GQMVGDHTRLEFHNIETGVMTERRFVSHIPSSFIGHLQSLKFNGLLYIDLCKNGDIDYCELNARFGMRSIIAD-PVTFKAKSSYLSLATLQAYTSMHLFFQFKTTSADGIILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNLIKGNSDRPLNDNQWHNVVITRDNSNLHTLKI-------DAKAVSQVVNGAKNLDLKGDLYIAGLGPNMY-----NSLPKLVASREGFKGCLASVDLNGRLPDLINDALFRSGQIERGCEVGFIKADL----QGPSTTCQEDSCANMGICIQQWENYTCDCSMTSYTGTQCNDPGTTYIFGKGGGTITFNWPANERPSTRTDRLTVGFSTSL-KDGILVRIDSAPGLGDYLMLHI----EQGKISVTFNIGTVDIIVQENSIPVNDGKYHVVRFTRNGGNATLQVDNWAINEHFPAGNNDNERLQMANKKIPFKYARPVEEWLQEKGRQLTIFNTQATITIGGND--RKRPFQGQLSGLYYNGLKVLN 1275
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Match: nrxn3a (neurexin 3 [Source:NCBI gene;Acc:103035103]) HSP 1 Score: 295.049 bits (754), Expect = 1.695e-80 Identity = 306/1367 (22.38%), Postives = 554/1367 (40.53%), Query Frame = 2
Query: 137 VNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAM--------NTCYFDSNFCRYCSSSK--KCTKYEYL---------------------------------TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTL---NIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGS----------IYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQF---FMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEAN-EKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS--INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQN-----------------------------TVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILD 3895
+T S LSFQ K D L+ Y +D F+ L ++ K++L + ++T ++ +++ WH + + + +L + ++ + +++ + D +F GGLP+ ++ S ++ P F G +R +++ R +P ++ Q M N C + C C+K EY+ TF + Y + I + I FKT Q N + + G ++++ ++DG ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N++ L + +V K+ K+ D+ C + + P+SF Y+ + R S F+T + + LI + +P +K +T DF+++E+ D +LY + + S + V++G +++ + + I ++ S ++ EG +Y+G L D + L + +W+ +L + GCI L ID + + + + +G K S S C + PC N+G+C+ W++ CDCT T + TC +EA I ++G +M++ P +E E+ L F S+ GL+++T ++ S T +LE+ +GS I I N +G + + D++WH++++ RR K+ K+ +DD+ E G + D + N + +R + F+G++ +NG Y +L K EL A +++ + F + SYL + + + L FQ KT G++LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S H+ D++A V G N + G +++ G N N P+ S+ GF+GC+AS +N + DL+ +A ++ C C DSC+ G C Q W Y+CDCS TS++G +C D TT F K + + + ++ S ++L GF T+ K L+ I L L + I + G I V + T E+ + V DG YH+VRF ++ ATL++D+ + H P G + N T+ + + +G ++ K FQG +SGL N + +L+
Sbjct: 41 ASTRSDLSFQFKTDASTALVLYFDDGGYCDFLQL-MVVEGKLQLQFSIDCAETT-------------------VVSDKRVND--SSWHFVSLGRYNLRTVLGVDGANKADEV----RPQRQYMKIVSD-LFLGGLPQDIR--TSVLTLPTAKDLPPFKG---IIRDLKYGRK--VPTLLSSQKVRMDMEGICTENPCE-NGGICSLVDGEPLCDCSKTEYIGRFCSEEANSIPGLAHMMMADQAKSKAREENVATFRGSEYFCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGK-----------SADYVNLALKDGAVSLVIN---LGSGAFEAIVEPVNGKFN---DNVWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIVDPKM-------KIQGDVVFKCENVATLDPISFETPEAYISLPKWNTKRMGSISFDFRTSEPNGLILFTHGKPQDRKATGSQKNTKVDFFAVELLDGSLYLLLDMGSGTIKVKATQNKVNDGAWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPDNRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKDIRQIAEAQNG--AGIKPSCNKVSGKQCESYPCKNKGVCKEGWNRFVCDCTGTGYWSRTCEREASILSYDGSMYMKVVMPTVMHTEAEDVSLRFMSQRAYGLLMATTSRDSADTLRLEL---DGSRVKLTVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVIRRGKSYKLTVDDDVAE-------------------------GQMVGDHTRLEFHNIETGVMTERRFVSHIPSSFIGHLQSLKFNGLLYIDLCKNGDIDYCELNARFGMRSIIAD-PVTFKAKSSYLSLATLQAYTSMHLFFQFKTTSADGIILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNLIKGNSDRPLNDNQWHNVVITRDNSNLHTLKI-------DAKAVSQVVNGAKNLDLKGDLYIAGLGPNMY-----NSLPKLVASREGFKGCLASVDLNGRL--------PDLINDALFRSGQIERGC----EGPSTTCQEDSCANMGICIQQWENYTCDCSMTSYTGTQCNDPGTTYIFGKGGGTITFNWPANERPSTRTDRLTVGFSTSL-KDGILVRIDSAPGLGDYLMLHI----EQGKISVTFNIGTVDIIVQENSIPVNDGKYHVVRFTRNGGNATLQVDNWAINEHFPAGNNDNERLQMANKKIPFKYARPVEEWLQEKGRQLTIFNTQATITIGGND--RKRPFQGQLSGLYYNGLKVLN 1275
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000002142.1 (pep scaffold:Pmarinus_7.0:GL476386:209124:506099:1 gene:ENSPMAG00000001935.1 transcript:ENSPMAT00000002142.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 284.263 bits (726), Expect = 3.787e-78 Identity = 284/1195 (23.77%), Postives = 504/1195 (42.18%), Query Frame = 2
Query: 761 EYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFY---TRKFHCNSIYKTCADDKWHNVQI----KEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMK---FAKATEPFQYY----RQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY------QPSSKKGIHT-DTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGR----------GNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKL--VSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEK-HYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG-IDQ--------------NTVVDEELM------------AIVGSSEVSSKNSFQGFISGLTINEIAILD-TLKENFNSYILLINKSNADLV----------PNFQPRRSDQSLKQSEEEPKNPETNQKNNR-------------IVVARPQCP 4075
EYL +D A P+ S+ I FKT Q N + + G ++++ ++DG ++I+ + T KF+ D+ WH+V++ ++ + ++ Q + LT T + + ++ F Y LP P + F GC+KE+ ++ L + ++ + G++ S C + + P++F ++ ++ R S F+T + LI + + KG+ + DF++IE+ D L+ + + S + NV++G +++ + I ++ + + ++ + +++G L +D L + +WS +L + GC+ L ID + L ++ ++ +G K S C++ PC N G+C+ W++ CDCT T +TG +C +EA I ++G FM++ P +E E+ L F S+ GL+L+T ++ S T +LE+ + I L+ R G + ++ D+ WH++++ RR K LK+ +D G++ D D + + + I+ + + FMG++ + ++NG Y +L + EL A ++ I F + SYL + + + L FQ K+ GL+L+ G++NDY+ +E+V G +H I++ G+G + + +LND WH+V I R + H+ K D VN G N + G + +GG +S+ + S+ G+QGC+AS +N + DLLKEA+ K + ++ C C SC G C QHW ++CDC+ TSFSG C D TT F K + Y + + S ++LA GF T+ K A L+ + +L + + IK G + V + T S E+ + V DG YH+ RF ++ TL+LD+ P G ID VVD+ L+ A + + FQG ++GL N + +L T K + N + + N LV P+ R +D+S+ E ++NR I+VA +CP
Sbjct: 13 EYLCYDL-----AAHPIQSSSD---EITLSFKTLQRNGLILHTGK-----------AADYVNLALKDGAVSLVINLGSGAFEALVEPVTGKFN---------DNNWHDVKVTRNLRQLSSIGHAMVNKLQIVVTISVDGILTSTGYTQEDYTMLGSDDFFYVGGSPNTADLPGSPISNNFMGCLKEVIYKNSDQKLELSKLAKEGEPKMKVVGEI-SFTCENVAALDPITFEAPEAFITLPKWKTKRTGSISFDFRTTEPSGLIIFTQGKVSEVKDSKGLRSRKGDFFAIELFDGHLFLLLDMGSGTIKLKATESNVNDGEWYHVDFQRDGRTGSISVNSQRSPFTAGGDNEILDLDSEVFLGGLPEDKADLLLPTELWSALLNIGYVGCVRDLFIDGQSKDVRQLAEQQNA--AGVKPFCAKDSPKQCSSNPCRNHGVCREGWNRYVCDCTATGYTGRSCEREASILSYDGSMFMKVVMPVVIHTEAEDVTLRFVSQRAYGLLLATTSRDSADTLRLELDSARVKLTINLDCVRIKCNSTSARKGPEILYAGKHLNDNVWHTVQVIRRGKTLKLTVD------------------------GTSADGLMDGDHTRLEFHNIETGIMTERRYTSVMPSNFMGHLQNVVFNGMAYIDLCRNGDIRYCELNARFGMRTIIAD-PIIFKTRGSYLTLATLQAYTSMYLFFQFKSTSSDGLILYNSGDANDYIAVELVKGHIHYIFDLGNGQDLIRDNSKRVLNDNRWHNVIISRDNNNIHTL------KVDTQTVSQNVN-GARNLDLKGDLFIGGL--EKSMYAKLPKLVASREGYQGCLASLDLNGRL--------PDLLKEASYKVNEIERGC----EGPSTTCQEYSCGNQGMCVQHWATFTCDCTMTSFSGAYCNDPGTTYIFSKGGGLITYTWRPNDRPSTRADRLAVGFSTHL-KDALLVRVDSAATLGDFIELYIK----QGKVGVTFNVGTEDISVNETNVAVNDGNYHVARFSRNGGNCTLQLDNHPINERYPSGNIDNERLALARQRIPYRLGRVVDDWLLDKGRQLTIFNSQATITIGGQDRERPFQGQLAGLYYNGLQVLHLTAKNDPN----IKTQGNVRLVGDVPSILSTEPSATVRPTDRSMTFMEISTTIASATPRHNRPPTRDSLSSVSDDILVASAECP 1121 HSP 2 Score: 110.923 bits (276), Expect = 1.685e-24 Identity = 111/478 (23.22%), Postives = 207/478 (43.31%), Query Frame = 2
Query: 2075 NKEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-----DDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGE-------------SNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLN--FNHFGKMHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCE 3400
+E +A F G +++ + +S + L FK+ NGLIL T D + + +++G++ +++N G G F+ L D+ WH +K+ R + L + N L++ + I + ++ + + Q+ + L S+D ++G + FMG + IY + +LAK+ P + + S NV I F + ++++ +PK + F +T +PSGL++F QG+ D+ +E+ +G L ++ + GSG K K +ES + NDG W+ V R +T S + + R+ P GG N + ++ LGG E+++ + E + G+ GC+ +++ KD+ + A +++ P D CS + C G C + W +Y CDC++T ++G CE
Sbjct: 1 GREESMATFKGSEYLCYDLAAHPIQSSSDEITLSFKTLQRNGLILHTGK----AADYVNLALKDGAVSLVINLGSG--AFEALVEPVTGKFNDNNWHDVKVTRNLRQLSSI----GHAMVNKLQI-VVTISVDGILTSTGY-----TQEDYTMLGSDDFFYVGGSPNTADLPGSPISNNFMGCLKEVIYKNSDQKLELSKLAKEGEPKMKVVGEISFTCENVAALDPITFEAPEAFITLPKWKTKRTGSISFDFRTTEPSGLIIFTQGKVSEVKDSKGLRSRKGDFFAIELFDGHLFLLLDMGSGTIKLKATESNV-NDGEWYHVDFQRD-GRTGSISV------NSQRS--PFTAGGDNEILDLDSEVFLGGLPEDKADLLLPTELWSALLNIGYVGCVRDLFIDGQ--------SKDVRQLAEQQNAAGVK-PFCAKDSPKQCSSNPCRNHGVCREGWNRYVCDCTATGYTGRSCE 443
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000004299.1 (pep scaffold:Pmarinus_7.0:GL477235:143017:163597:1 gene:ENSPMAG00000003933.1 transcript:ENSPMAT00000004299.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 132.494 bits (332), Expect = 9.005e-34 Identity = 102/384 (26.56%), Postives = 171/384 (44.53%), Query Frame = 2
Query: 2291 GRGNKKFKTLENCFDDKWHSIKM----KRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKR-KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVD--------GKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCED 3403
G+G + + D++WH++++ KRR K LK+ +D E + EM +++ I + G + + +V ++ F+G++ ++NG Y +L K E+ A ++ + F + SYL + + + L FQ KT+ P GLLL+ G+ D++ LE+V G LH ++ G G K G LND WHSV ++R + H+ D + D + D+ V GGL H+ +H + +V S+ GFQGC+AS +N + L D L+ + + ++ C C DSCS G C Q W +++CDC+ TS++G C D
Sbjct: 2 GKGPEVLHAGQKLNDNEWHTVRVSRRGKRRGKLLKLSVD----EVSKEDEMAGDHTRLEFHNI----ETGIMTERRYTSVVPSN--------------FIGHLQSLVFNGLPYLDLCKNGDVALCEINARFGLRTIIAD-PVTFRTRSSYLTLATLQAYAAMHLFFQFKTMSPDGLLLYNGGDGTDFIALELVQGYLHYAFDLGKGPSVIKGKSEGQLNDNQWHSVIVMRDANNLHTLKVDRDMATQNGNEARNLDLKGDLFV--GGLPREHYSGLH-------KLVV--------SRDGFQGCLASVDLNGRLPD----LLDDALRRSGQ---IERGC----EGPSTVCQDDSCSNQGLCVQQWEEFTCDCTMTSYTGAFCND 334 HSP 2 Score: 73.9442 bits (180), Expect = 4.389e-14 Identity = 57/245 (23.27%), Postives = 109/245 (44.49%), Query Frame = 2
Query: 1358 KLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLN---SVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDS-PIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCN 2077
++N+ + PV+F +S YL +++ FKT D L+ Y TDF ++E+ L+++ L SV+ K S +++ H++++ + + L + +++ +G L++G L + V S F GC+ S+ ++ P LD ++++ I GC+ VC + C N+G+C +W++ +CDCT T++TG CN
Sbjct: 105 EINARFGLRTIIADPVTFRTRSSYLTLATLQAYAAMHLFFQFKTMSPDGLLLYNGGD------GTDFIALELVQGYLHYAFDLGKGPSVIKGK--SEGQLNDNQWHSVIVMRDANNLHTLKVDRDMATQNGNEARNLDLKGDLFVGGLPREHYSGLHKLVVSR---DGFQGCLASVDLNGRLPDLLDDALRRSGQIERGCEGPS-----TVCQDDSCSNQGLCVQQWEEFTCDCTMTSYTGAFCN 333
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000007718.1 (pep scaffold:Pmarinus_7.0:GL476589:4931:52526:1 gene:ENSPMAG00000006969.1 transcript:ENSPMAT00000007718.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 87.8113 bits (216), Expect = 8.634e-18 Identity = 109/494 (22.06%), Postives = 187/494 (37.85%), Query Frame = 2
Query: 2015 IEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFY-LMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLE-------NCFDDK-WHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQ---PANVMRQFAINFHSTKSYLVI-----------PKVNIFGDFRLEFQMKTLQPSGLLL----FLQGESNDYLILEMVNGLLHII--YNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHY----VDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKC 3397
IEW+ + G C + +A F+G + +F + + ++ L ++K +G++L + Q G L + + G + + L FG + + + DD+ WH + + R ++ + +D + F ++G D Q S L GK + F+G M + YNG + +LA++ P I +T ++ PA V + F S YL + P++ G Q +T +GLLL +QG + L L + G LH+ N + + LNDG WH V + ++ S VDG+ ++ N +FG + T + F GC+ +++N D +L + LL H+ + + C NH C GG+C Q W +SCDC TS++G C
Sbjct: 29 IEWNPEGHIGLRVELYG--CPYRSSVAYFDGRSLLAYRFEHKVRRTRKDVVSLRMRTKRSDGVLLHGEGQRGG---GLTLQIHRGRLNLHLRFGMEGDAGEGMGYITVSAGSLLDDQHWHDVTITRSGRHGNLTVDRHMQRFQ---------------VMGDYESLDLDYQLSFGGLPFG-----GKPGNRAHPNFLGCMENVYYNGEDVTDLARRAKP-QIHITGNVMFGCPAEVAL-IPVTFPSPGGYLALAGHLLWPNHAQPQIQSLG-----LQFRTWDAAGLLLQVVSVVQGHGVEGLRLALSEGKLHMTSSLNLQGRTELFLVTGSSLNDGEWHGVTL---QARDDSLLVMVDGREHFVMLSPVLHLIAGNAYYFGGTN-----------TTPGHPQSAVAPFLGCMRLIHMDNQ-PVDITLLQQGLLGTFINVHFDLCGLTDRCLPNH-----------CEHGGRCMQTWGGFSCDCQGTSYTGSTC 464 HSP 2 Score: 62.7734 bits (151), Expect = 4.626e-10 Identity = 89/465 (19.14%), Postives = 170/465 (36.56%), Query Frame = 2
Query: 773 FDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQF-------ISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSN-QQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGI------RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSL-NVCANQPCNEG-ICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFM 2119
FD S + Y F V ++ + +TK+ + L + G QI + + + +G+ +I +S +D D WH+V I +T+D + F+ + + + L + F PF P F GCM+ +Y + +VT ++ + H G + C + PV+F YL G + L F+T + L+ S +G + ++ + S+ L +++ ++++G H + L + +++D + + +S H I + Y G + T H S + F GC+ + +D+ P+ + LL + + + ++ L + C C G C W SCDC T++TG+TC+ A Y+ +
Sbjct: 55 FDGRSLLAYRFEHKVRRTRKDVVSLRMRTKRSDGVLLHGEGQRGGGLTLQIHRGRLNLHLRFGMEGDAGEGMGYITVSAGSLLD------------------DQHWHDVTITRSGRHGNLTVDRHMQRFQVMGDYESLDLDYQLSFGGL--PF-----GGKPGNRAHPNFLGCMENVYYNGEDVT----DLARRAKPQIHITGNVMFG-CPAEVALIPVTFPSPGGYLALAGHLLWPNHAQPQIQSLGLQFRTWDAAGLLLQVVSVVQGHGVEGLRLALSEGKLHMTSSLNLQGRTELFLVTGSSLNDGEWHGVTLQARDDSLLVMVDGREHFVMLSPVLHLIAGN-AYYFGGTNTTP-----GHPQSAV--APFLGCMRLIHMDNQPVDITLL--QQGLLGTFINVHFDLCGLTDRCLPNHCEHGGRCMQTWGGFSCDCQGTSYTGSTCHTPAYELSCEAYKHL 479
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Match: cntnap2b (contactin associated protein like 2b [Source:ZFIN;Acc:ZDB-GENE-070912-26]) HSP 1 Score: 76.2554 bits (186), Expect = 4.917e-14 Identity = 88/470 (18.72%), Postives = 181/470 (38.51%), Query Frame = 2
Query: 2015 IEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPN-TYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFG--RGNKKFKTLE--NCFDDK-WHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQ-GESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDS-RADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKC 3397
++W+ + G EA+ F+G + +F T ++ + L F+S L G++L + Q D L + +Q G +++L++ R + + + DD+ WH + + R ++ + +D + F+ D D +L+ + GK + F+G + + Y+G +LA+++ P +++ + + + F +L + + + +T P+GLLL L L + G L++ +S LN+G WH+ + ++ + VDG D + R+ +P + + +FG S +TF RS F GC+ +++ + +++ N + + + C + C C GG C+Q W + C+C+ T ++G C
Sbjct: 95 LDWNAYRWVGLRVEVYGCPYKSEAVF--FDGRSLLAYRFEQKTRRTRKDVVSLRFRSALSEGVLLHGEGQRG---DTLTLELQRGCLHLLISLDDVRSQVAYTSASAGSLLDDQHWHDVMLVRSGRHGNLTVDRHTQRFH--------------------VKGDDDSLDLDYQLMFGGLPFGGKAGSVGRPNFLGCLENVYYSGEYVTDLAQRIKPQIHMSGNVTFGCPRGVPAIPVTFPGPDGHLALTGRVGRAALAVAMEFRTWDPAGLLLLTALSRGLGELRLTLREGKLNLALIRPGSSDIHLSSGKQLNNGEWHTASV---QARERTLTLVVDGAEDTAVRSLLPFHVATGSIYYFGGA--------DSRLTFSKNLIRSLPPFLGCMRLINIDDHLVDLSLLQQG---LLGNYTNLMLDQC-----GLTDRCLPSHCENGGTCSQTWRSFECNCAGTGYTGVTC 520 HSP 2 Score: 63.5438 bits (153), Expect = 3.362e-10 Identity = 72/291 (24.74%), Postives = 120/291 (41.24%), Query Frame = 2
Query: 2561 ENQFFMGYMMHFIY-------NGRNYFELAKKLSPLNIELTASLQPANVMRQF--AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNG-LLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGG-LNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKC 3397
E+ +GY H R E A K+ PL+ + R F ++ F + SYL P + + F KT SG++L G S D++ +++ + + ++ G+G + + LND WH V + R + + + RVD P R VP G + ++++G + S GF GC+ S +N + DL + A V C + +Y S+ C GG+C + + YSCDCS++S++GP C
Sbjct: 684 EDSGLLGYKPHLPVMQLLIGDTDRALSEAAYKVGPLS---------CHGDRHFWNSVLFTTPSSYLHFPPIRAETSLDIAFFFKTTTDSGVILENMGAS-DFIRVQLKSPHEVSFSFDVGNGPVEMAVRSEQPLNDEEWHVVSVERSLKEA---SLRVDLLP---RELVPAPAQGHTSLQLSSQLYVGSSVSGHS-------------GFLGCVRSLRINGAT--------LDLEERARVTPGVKPGCSGH---CRSYGSL--CRNGGRCIERYNGYSCDCSTSSYNGPSC 932 HSP 3 Score: 50.0618 bits (118), Expect = 4.337e-6 Identity = 55/232 (23.71%), Postives = 96/232 (41.38%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIR---DFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFEL--PVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKE 2083
V FT S YL IR+ + FKT +I + +DF ++++ + + F +G N V V S +++ H + + L +R+ L V + + ++ LY+GS SVS H SG LG C+ SL I+ + + L+ + + GC + ++C N G C ++ SCDC+ +++ G +C E
Sbjct: 731 VLFTTPSSYLHFPPIRAETSLDIAFFFKTTTDSGVILENMGA-------SDFIRVQLKSPHEVSFSFDVG-NGPVEMAVRSEQPLNDEEWHVVSVERSLKEASLRVDLLPRELVPAPAQGHTSLQLSSQLYVGS-------SVSGH--SGFLG-----CVRSLRINGATLDLEERARVTPGVKPGCSGHCRSYG-SLCRNG----GRCIERYNGYSCDCSTSSYNGPSCTNE 935
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000000532.1 (pep scaffold:Pmarinus_7.0:GL482851:1933:10168:1 gene:ENSPMAG00000000481.1 transcript:ENSPMAT00000000532.1 gene_biotype:protein_coding transcript_biotype:protein_coding) HSP 1 Score: 73.9442 bits (180), Expect = 6.091e-14 Identity = 68/255 (26.67%), Postives = 122/255 (47.84%), Query Frame = 2
Query: 2699 AINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGL-LHIIYNWGSGYKRKISESGL-LNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKY 3457
A +F + +SYL P V+ + F KT SG+ L G ++D++ +++ + + ++ G+G + SG LND WH+V + R + + + RVD P + A VP + G + ++++G + S GF GC+ S VN +V+L DL ++A V+ C + +Y ++ C GG+C +H + YSCDCSS+ + GP C + F + +++ Y++
Sbjct: 5 AASFSTHRSYLHFPPVHAETSLDITFLFKTSAESGVFLENMG-THDFIRVQLKSPYEVSFGFDVGNGPVEMVVRSGQPLNDEEWHAVSVERSLKEA---SVRVDRLPREV-AWVP-SRGHAHLQLNSQLYIGSSVSGDS-------------GFLGCVRSLRVN------SVML--DLEEQARVTPGVNPGCSGH---CRSYGAL--CRNGGRCVEHSVGYSCDCSSSPYDGPFC--TTEVGGFFERGTWVKYEF 225
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Match: EDO46873 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RNK6]) HSP 1 Score: 85.1149 bits (209), Expect = 1.314e-16 Identity = 134/660 (20.30%), Postives = 259/660 (39.24%), Query Frame = 2
Query: 2078 KEAIIAEFNGYQFMRI-KFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDK----LEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRME---------NQFFMGYMMHFIYNGRNYFELAKKL-----------------------SPLNIELTASLQPANVMRQFA----------INFHSTKSYLVIPKV--NIFGDFRLEFQMKTLQPSGLLLF---LQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK-MHLGG---YLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSF-GGKCTQHWMKYSCDCSSTSFSGPKCEDVS-TTAQFVKHPSYLVYKYS-IIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGI---DQNTVVDEELMAIVGSSEVSSKNSFQGFISGLT 3871
+ A F G +M + + P + ++ E +MFK+ +GL+L + G DK L + ++NG + + G + ++ +N ++WH++ + R +++ + +D+ ++ + + D ++L LG V RM + F G + F+ +GR +L++ L +P + ++ A + + + S +SYL P + F + +K +GL+LF + D++ L + G++ I++ GSG S + ++ D +WH++ I R + +DG P V + G ++ + ++LGG Y + +IV + GF GCI VN + E H N + ++ C F GG C Y C C+ ++G CE +A ++ +K S I+ + S F T++ + L+ + +S+S I I +++ G ++V Y G + + S + DG +H V+F + +AA LK+DD + GI Q ++ +++ I G+ V + F+SGL
Sbjct: 65 RSARQPRFKGTSYMSLPRLPRSARTSFE-LSIMFKASSGDGLLL-----YGGRKDKRKDFLALGLRNGHVEFRFSCGADIAQVRSRQNITLNQWHNVVVFRDKRDAHLMVDNGD-------------------LVTQSLKGTQSMMDLKTRLF------LGGVPRMRRVTSDAVPYHSGFTGCVKSFVVDGR-MLDLSQALGDVVKSRQVEECGESRDCECHHNAPCHYAVSGEPICACPLGTYGRLCEHDFKLVMPSFSGQSYLTYPSFGQSTLRTFTISLVLKPRSDTGLILFNSQKKDGKTDFISLSLREGIVEFIFDCGSGPAVIRSSTPIMAD-IWHTIVISR---DGRTGGLSLDGGP----PVVGTSPGRMSLISLEQEVYLGGMADYKQQPAIVDMPH-------GFNGCIQEVKVN-----------------SRELHLPSARSGLNVLNCDHICVTHLLCFNGGTCQAKMDHYKCHCA-VGYTGMMCERARRVSAPTFAGDGFMKFKGSEILSRLSGKNTELEFLFRTQESSGLLLSVQKESVSHGDHITIGLID--GILEVRYDLGVGRETVIRSTATLDDGYWHSVKFVRKSLAAYLKVDD-----EIKAGIASDSQYRQLNSDVLFIGGAPTVDRR-----FMSGLV 647 HSP 2 Score: 79.337 bits (194), Expect = 8.031e-15 Identity = 106/490 (21.63%), Postives = 184/490 (37.55%), Query Frame = 2
Query: 1061 DKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLN-----------IVEMVTKKVYNFHSNGKLN----------------SDICMEMFPIKPVSFTGKSDYLQ--AFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRD--FALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHD-IEFEGSLYIGSLDDTK----ILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC--NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAE--FNGYQFMRIK---FPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDK-WHSIKMKRRRKNLKVWIDD 2398
++WHNV + + D + +D+ ++L Q + + P R+ P S F GC+K + + L+ + E + H N + +C F + SF+G+S YL +FG ++R SL K LI + K G TDF S+ +R+ F G V + S+ + + H IV+ + + LD V+ S I E +Y+G + D K I+ + H F+GCI + ++ + L S SG ++ ++C N G CQ + D C C +TG C + ++ F G FM+ K + + +F+++ +GL+LS Q + D + I + +G + + + G G + DD WHS+K R+ + +DD
Sbjct: 150 NQWHNVVVFRDKRDAHLMVDNGDLVTQSLKGTQSMMDLKTRLFLGGVP--RMRRVTSDAVPYHSGFTGCVKSFVVDGRMLDLSQALGDVVKSRQVEECGESRDCECHHNAPCHYAVSGEPICACPLGTYGRLCEHDFKLVMPSFSGQS-YLTYPSFGQSTLRTFTISLVLKPRSDTGLILFNSQKKDG---KTDFISLSLREGIVEFIFDCGSGPAV---IRSSTPIMADIWHTIVISRDGRTGGLSLDGGPPVVGTSPGRMSLISLEQEVYLGGMADYKQQPAIVDMPHG---------FNGCIQEVKVNSRELHL-------PSARSGLNV---LNCDHICVTHLLCFNGGTCQAKMDHYKCHCA-VGYTGMMCERARRVSAPTFAGDGFMKFKGSEILSRLSGKNTELEFLFRTQESSGLLLSVQKESVSHGDHITIGLIDGILEVRYDLGVGRETVIRSTATLDDGYWHSVKFVRKSLAAYLKVDD 610 HSP 3 Score: 60.4622 bits (145), Expect = 4.824e-9 Identity = 68/328 (20.73%), Postives = 139/328 (42.38%), Query Frame = 2
Query: 1448 RSVRKA-KFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVL-NISTNYHDIEFEGSLYIGSLDDTKIL---SVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCA---NQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKE--AIIAEFNGYQFMRIKFPNTYKSEVENFY--LMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWID 2395
RS R + + S+ FK D L+ Y K DF ++ +R+ + F + + ++V S N++ HN+V+ + +++D + V ++ ++ + L++G + + + +V +H + F+GC+ S +D LDL + S + EE C N PC+ + + C C + G C + ++ F+G ++ +P+ +S + F L+ K + GLIL + G TD + + ++ G + + + G G ++ D WH+I + R + + +D
Sbjct: 85 RSARTSFELSIMFKASSGDGLLLYGGRKDK----RKDFLALGLRNGHVEFRFSCGADI-AQVRSRQNITLNQWHNVVVFRDKRDAHLMVDNGDLVTQSLKGTQSMMDLKTRLFLGGVPRMRRVTSDAVPYH-------SGFTGCVKSFVVDGR--MLDLSQALGDVVKS--RQVEECGESRDCECHHNAPCHYAVS----GEPICACPLGTY-GRLCEHDFKLVMPSFSGQSYL--TYPSFGQSTLRTFTISLVLKPRSDTGLILFNSQKKDGKTDFISLSLREGIVEFIFDCGSGPAVIRSSTPIMADIWHTIVISRDGRTGGLSLD 389
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Match: EDO47422 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RM09]) HSP 1 Score: 78.9518 bits (193), Expect = 8.655e-15 Identity = 73/319 (22.88%), Postives = 138/319 (43.26%), Query Frame = 2
Query: 1463 AKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGS---LYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLD-LLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNG--YQFMRIKFPNTYKSEVEN-FYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCF-DDKWHSIKMKRRRKNLKVWID 2395
+ S F+T++S+ L+ YQ G+H DF + + + + IG++ + + + ++ H + + E + +D+ L S + D + LY+ S T L+++ V F GC+ L S +LD ++ +S +SGC + LN C + G C E + C+C T + G+ C E+ A FNG Y + +S + N F + P+G+I+ + S D + + + G + + + G+G + E C D WHS+ + R+R+ + + +D
Sbjct: 44 GEVSFVFRTNQSNGLLLYQ---DDGMH---DFVELFLDNGNVRIKIGIDDCYIQEKLVQGSFNDFHWHRVRITREPRNVTFAVDRAWLKLPCSPSKGDKFARATGRFLYVASFPPTLGLNLNWLV--------FPGCLGDLWFTTSEQRLDQATLRDSSGTTSGCNSPCRTPQLNKCLHG----GRCSAEIGRVECECQGTGYEGDDCGIESSSAWFNGSSYVLYDVGIHQPGRSTLTNTIAFRFATGNPDGVIVHS----SMFDDHVVVELSKGFVRVSFDLGQGRLNITSREGCLHDGTWHSVTIHRKRRRVTLDLD 340 HSP 2 Score: 64.6994 bits (156), Expect = 2.614e-10 Identity = 94/412 (22.82%), Postives = 159/412 (38.59%), Query Frame = 2
Query: 2723 SYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKG------GFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHS---INQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVD----EELMAIVGSSEVS------SKNSFQGFISGLTINEIAILDTL 3901
SY N+ G+ + F +T Q +GLLL+ +D++ L + NG + I Y ++ G ND WH V+I R + + F VD RA + + + F + G +L S P + G F GC+ + S L + L++++ C N ++ C GG+C+ + C+C T + G C S++A F SY++Y I + N +AF F T P I+ + + +E+ GF++V + G + + DG +H V + R TL LD V G Q + +D +E + G + S+ +F G I L +E ++D +
Sbjct: 33 SYTTFEPWNLHGE--VSFVFRTNQSNGLLLYQDDGMHDFVELFLDNGNVRIKIGIDDCYIQEKLVQGSFNDFHWHRVRITR---EPRNVTFAVD------RAWLKLPCSPSKGDKFARA-TGRFLYVASF-------PPTLGLNLNWLVFPGCLGDLWFTTSEQR----LDQATLRDSSG---TTSGC----NSPCRTPQLNKCLHGGRCSAEIGRVECECQGTGYEGDDCGIESSSAWF-NGSSYVLYDVGIHQPGRSTLTNTIAFRFATGN----PDGVIVHSSMFDDHVVVELS----KGFVRVSFDLGQGRLNITSREGCLHDGTWHSVTIHRKRRRVTLDLDKQERVTVVIPG--QFSFLDFKGGQEKLYFCGGPDSDTLAYSYSRKNFTGIIQQLRFDEYQVIDEV 403
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Match: EDO39258 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SAQ4]) HSP 1 Score: 73.559 bits (179), Expect = 4.936e-13 Identity = 81/346 (23.41%), Postives = 149/346 (43.06%), Query Frame = 2
Query: 1058 DDKWHNVQIKEFRNDIVITLDDFQKEFKNLSN---QQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFY-SIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDI-EFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSG-CKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTC 2074
D+KWH V++ + +++TLD+ + + L K I + + P Y+ P F+GC+K++Y ++I+ ++ + + G+L S IC + PV F + +L+ + S LSF+T+ D ++A++ + TD Y S+ L IG + + K+ N+++GL H++ + + LD + V + + +I +F YIGS G T F GC+ ++ ++ + ++ L K+ + G C + + C PC N G C+ WD +CDC T + G TC
Sbjct: 15 DNKWHTVKVARNQRSLLLTLDNKETRTNTAGSFVRLDLDKFIFVGGVDRSLPDDYHGARDAPN------FKGCLKDVYFD----FIDILYGAQYELLYYSTYGRL-SYIC-PLDDYTPVGFPSLNTHLRLTDL-SPNNFTVWLSFRTYSGDGVLAFK------MSTDARVYLSLVHAKLELEIRIGTDRPI--KISLGENLNDGLWHDVTSGINRKELWLTLDDKPEVRHANPWLKNIGKFRRRTYIGS---------------GTQKTGFVGCMNNIKLNGALVRPRKLSKEVAGAVIGRCSITSK------CFPNPCQNGGACKESWDSYTCDCQGTFYEGATC 318 HSP 2 Score: 58.9214 bits (141), Expect = 1.831e-8 Identity = 86/374 (22.99%), Postives = 146/374 (39.04%), Query Frame = 2
Query: 2321 ENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFN---NFLEMDMPIIGIKYLIIG----SAFDNGTDIQDSSS-----KLVSNDIIHLGKVKRMENQFFMGY-MMHFIYNGRNYFELAKKLSPLNIELTAS-LQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCE 3400
EN D+KWH++K+ R +++L + +D+ N +F+ +D+ K++ +G S D+ +D+ + K V D I + + E ++ Y + +I +Y + LN L + L P N + +S GD L F+M T + + L +V+ L + G+ KIS LNDGLWH V + + +D KP+ A+ + GK Y+ + + K GF GC+ + +N ++ + + L KE V C + C + C GG C + W Y+CDC T + G CE
Sbjct: 11 ENLDDNKWHTVKVARNQRSLLLTLDNKETRTNTAGSFVRLDLD----KFIFVGGVDRSLPDDYHGARDAPNFKGCLKDVYFDFIDILYGAQYELLYYSTYGRLSYICPLDDYTPVG--FPSLNTHLRLTDLSPNNFTVWLSFRTYS-------------GDGVLAFKMST--------------DARVYLSLVHAKLELEIRIGTDRPIKISLGENLNDGLWHDVTSGINRKE---LWLTLDDKPEVRHANP-------WLKNIGKFRRRTYIGSGT----------QKTGFVGCMNNIKLNGAL-----VRPRKLSKEVAGA--VIGRC-----SITSKCFPNPCQNGGACKESWDSYTCDCQGTFYEGATCE 319
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Match: EDO36419 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7SIM8]) HSP 1 Score: 57.3806 bits (137), Expect = 7.532e-9 Identity = 59/226 (26.11%), Postives = 99/226 (43.81%), Query Frame = 2
Query: 1418 KSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGS--LYIGSLDDTKILSVSHHVWSGIL-GTYFSGCIFSLTID-DSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNK 2080
KS + Q R + SFKT D L+ YQ G+ D++++E++ L +I S+V +++ H + +H E I + LD V+ I ++ S LY G L + LS+S + ++ F+GCI + I + +Q +L + ++ GC+ N C + PC N G C + +CDC+ T F GN C +
Sbjct: 7 KSSFAQHQQWRVSSNGTLTFSFKTFLKDALLIYQDD---GV---MDYFNLELKVGRLLLNIRTGRKT-SQVTLGNQLNDLSWHQVSIHVEHVKIGLTLDDHTRVVKIPRKNLALKNNPSRYLYFGGL--PRSLSISTLSFPAVVFAKRFTGCIKDVEIQTGNGVQEELRLVESKGRVRGCR--------NACRSNPCQNGGRCINKIWSSACDCSGTGFYGNQCTE 215 HSP 2 Score: 51.6026 bits (122), Expect = 5.522e-7 Identity = 62/222 (27.93%), Postives = 83/222 (37.39%), Query Frame = 2
Query: 2768 LEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGL---LNDGLWHSVKI-VRHMSKTHSFAFRVDGKPDDSRA-DVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTA 3418
L F KT LL++ DY LE+ G L + G RK S+ L LND WH V I V H+ +D D +R +P L N ++ GG + SI T F GCI V T ++ L+ K V C N C + C GG+C +CDCS T F G +C + + A
Sbjct: 24 LTFSFKTFLKDALLIYQDDGVMDYFNLELKVGRLLLNIRTG----RKTSQVTLGNQLNDLSWHQVSIHVEHVK----IGLTLD---DHTRVVKIPRKNLALKNNPSRYLYFGGLPRSLSISTLSFPAVVFAKRFTGCI------KDVEIQTGNGVQEELRLVESKGRV-RGC-------RNACRSNPCQNGGRCINKIWSSACDCSGTGFYGNQCTEGESKA 220
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Match: EDO45834 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RRW5]) HSP 1 Score: 60.077 bits (144), Expect = 8.530e-9 Identity = 67/268 (25.00%), Postives = 110/268 (41.04%), Query Frame = 2
Query: 2753 FGDFRLEFQMKTLQPSGLLLFLQGE----SNDYLILEMV-NGLLHIIYNWGSGYKR---KISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDG------KPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSIN-QLAFGFQTN 3511
+GD L F+ + +LF QGE + D++ + + N + + Y+ G+G + +++E+ L + LWH V + ++ + F VDG P + V G + +GGY+ GF GCI F +N V +L + + + YV+E C N++ C G +CT + Y CDC T F G CE A F + SYL Y + ++ + A GF+T
Sbjct: 691 YGDVSLFFRTPYTRG---ILFHQGEKTRNTRDFIQVNITSNDTVQLSYDIGNGPQSIVVQVTENPLNTNRLWHKVVVWFNIKE---FGLEVDGIRKIRLNPLQQSKQLDV---------VGNLFIGGYMREM------------MNGFVGCIRGFTINGEVL--------NLARLSKDFDYVNEGCYSACNNETQ------CKGGARCTDDYNIYKCDCHLTPFYGYFCEQ-DLGAAFKETDSYLRYTFPEGERDAWGTDFAVGFKTG 916
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Match: ENSORLT00000013637.2 (neurexin 1 [Source:NCBI gene;Acc:101159771]) HSP 1 Score: 330.487 bits (846), Expect = 4.649e-92 Identity = 335/1453 (23.06%), Postives = 595/1453 (40.95%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCR---YCS---------------SSKKCT--------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHT-DTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANE-KHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN-----FNSYILLINKSNADLVP--NFQPRRSDQSL-------------KQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQE 4171
+SF +K + GL+ Y +D F+ L L+ + K+ L +F + T I D + D WHT+ I + K+ L + + V + KR D + +F GG+P +L+ A + EP F+G I+ V + +I + M+ C +N C+ CS K C+ K EY+ TF + Y ++ I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + L+ + QP K T DF++IE+ + LY + + S N V++G +++ + I ++ ++ + +LY+G L + K+ L VW+ +L + GCI L ID + L I+K + + C C + PC N GIC+ W++ CDC+ T + G +C +EA I ++G +FM+++ P +E E+ L F+S+ G++++T ++ S T +LE + +G + + +N +G + +N D++WH++++ RR K+LK+ +DD I G + T ++ + + I+ + F+G++ +NG +Y +L K EL A + N++ + F S SY+ + + + L FQ KT P GL+L+ G+ ND++++E+V G LH + + G+G + K + + L+D WH+V I R + H+ D++ TG N + G +++GG ++ + + + +K GFQGC+AS +N + DL+ +A + ++ C C DSC+ G C Q W +SCDCS T+F GP C D TT F + + Y + + S ++LA GF T+ K A L+ + + L L + I D G + V + T + E V DG YHIV+F + ATL++DDL P G + N VVDE L+ +G E SFQG +SGL N + + + E + L+ S + + P + RS+ S + + P+ P+ Q + +VA +CP ++ E + G+ P F PN E
Sbjct: 51 MSFNMKTKSSHGLLVYFDDEGFCDFLEL-LIRNGKLSLRFSIFCAEPA-----------------TVISDTAVND---SRWHTVTIRRNFKNTTLMVDNEIKWVEV-----MSKRRDMTVFSHLFVGGIPPELRSVALRLTSAAVKDEPPFAGWITDVTVNNTE-----CAIINSEGVLMDIC-GTANMCQNGGICSLIDNEPTCDCSHTGFQGKDCSEGLAHLMMGDQGMGKEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNDWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTV-AFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVDFQRDGRSGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDVRRLAEIQKATGVKPSCSKEPSKQ----CLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSYDGSKFMKVQLPVVMHTEAEDVSLRFRSQRAYGILIATTSRDSADTLRLE--LDSGRVRLTVNLDCIRINCTSSKGPETIFAGQNLNDNEWHTVRVFRRGKSLKLTVDD------------------LSPIEGQMAGDHTQLEFHN---IETGIVTEKRFMSTVPSNFIGHLQSLSFNGMSYIDLCKNGDIDYCELNAMIGFKNIIAD-PVTFKSRSSYVTLTTLQAYYSMHLFFQFKTTSPDGLILYNSGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNKPLSDNQWHNVIISRDTNNLHTVKI-------DTKITTQTTTGAKNLDLKGNLYIGGVAKD--MYMYLPKLVHAKEGFQGCLASVDLNGRL--------PDLMSDALDCVGQIERGC----EGPSTTCQEDSCANQGVCLQQWEGFSCDCSMTTFGGPLCNDAGTTYIFGRDGGLITYTWPPNDRPSTRADRLAIGFSTHL-KDAVLVRVDSSSGLGDFLKLHI----DKGKVAVVFNVGTDDINIEEKAKFVNDGKYHIVKFTRSGGNATLQVDDLPVNERYPTGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQTTIQIGGWERDRSQSFQGQLSGLYYNGLKVFNMAAEGDSNVKIQGSVRLVGDSPSSITPQSSTTANRSETSTSIMEITTTTASSRRVKQTTPREPQ--QTTDDFLVASAECP--SDDEDIDPCEPSSGGLANP--TFAGPNPPE 1382 HSP 2 Score: 163.31 bits (412), Expect = 7.450e-40 Identity = 195/907 (21.50%), Postives = 367/907 (40.46%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTY--FSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN--------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIK-YLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN--------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK---------MHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLL----TIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLS--------DRIHVP-DGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT S L+ Y +G DF + IR+ L + + V+S+ V++ H + + +++D E + + + D+ L++G + ++ SV+ + S + F+G I +T++++ + I + C T+ N+C N GIC + ++ +CDC+ T F G C+ KE +A F G +F N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + + + +D + + D ++G + +G + D VSN+ FMG + +Y + LAK+ P + I T + + NV I F + +S++V+ K N + F +T +P+GLLLF G+ D+ +EM+ G L+++ + GSG + + + +NDG W+ V F+ DG+ + +NT + G+ ++LGG EN+ + F E T G+ GCI +++ KD+ L E + V +C + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + LI+ S L + +++ + I++ ++ G + + N+ D +H VR + + L +DDLS D + I+ V ++ M+ V S +F G + L+ N ++ +D K
Sbjct: 28 LEFTGAEGQWARFPVWNACCESEMSFNMKTKSSHGLLVY--FDDEGF---CDFLELLIRNGKLSLRFSIFCAEPATVISDTAVNDSRWHTVTIRRNFKNTTLMVDNEIKWVEVMSKRRDMTVFSHLFVGGIP-PELRSVALRLTSAAVKDEPPFAGWITDVTVNNTECAI---INSEGVLMDICGTA------NMCQNG----GICSLIDNEPTCDCSHTGFQGKDCSEGLAHLMMGDQGMGKEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNDWHDVKVTRNLRQVTISVD-GILTTTGYTQEDYTMLGSDDFFYVGGS----PSTADLPGSPVSNN--------------FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTVAFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVD------------FQRDGR----SGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQ--------SKDVRRLAEIQKATGVKPSC---SKEPSKQCLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSY-DGSKFMKVQLPVVMHTEAEDVSLRFRSQ-RAYGILIATTSRDSADTLRLELDSGRVRLTVNLDCIRINCTSSKGPETIFAGQ-NLNDNEWHTVRVFRRGKSLKLTVDDLSPIEGQMAGDHTQLEFHNIETGIVTEKRFMSTVPS-------NFIGHLQSLSFNGMSYIDLCK 849
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Match: ENSORLT00000034989.1 (neurexin 1 [Source:NCBI gene;Acc:101159771]) HSP 1 Score: 321.242 bits (822), Expect = 5.132e-89 Identity = 336/1469 (22.87%), Postives = 597/1469 (40.64%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCR---YCS---------------SSKKCT----------------------KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQI-KEFRND-------IVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHT-DTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANE-KHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN-----FNSYILLINKSNADLVP--NFQPRRSDQSL-------------KQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQE 4171
+SF +K + GL+ Y +D F+ L L+ + K+ L +F + T I D + D WHT+ I + K+ L + + V + KR D + +F GG+P +L+ A + EP F+G I+ V + +I + M+ C +N C+ CS K C+ K EY+ TF + Y ++ I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + R + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + L+ + QP K T DF++IE+ + LY + + S N V++G +++ + I ++ ++ + +LY+G L + K+ L VW+ +L + GCI L ID + L I+K + + C C + PC N GIC+ W++ CDC+ T + G +C +EA I ++G +FM+++ P +E E+ L F+S+ G++++T ++ S T +LE + +G + + +N +G + +N D++WH++++ RR K+LK+ +DD I G + T ++ + + I+ + F+G++ +NG +Y +L K EL A + N++ + F S SY+ + + + L FQ KT P GL+L+ G+ ND++++E+V G LH + + G+G + K + + L+D WH+V I R + H+ D++ TG N + G +++GG ++ + + + +K GFQGC+AS +N + DL+ +A + ++ C C DSC+ G C Q W +SCDCS T+F GP C D TT F + + Y + + S ++LA GF T+ K A L+ + + L L + I D G + V + T + E V DG YHIV+F + ATL++DDL P G + N VVDE L+ +G E SFQG +SGL N + + + E + L+ S + + P + RS+ S + + P+ P+ Q + +VA +CP ++ E + G+ P F PN E
Sbjct: 51 MSFNMKTKSSHGLLVYFDDEGFCDFLEL-LIRNGKLSLRFSIFCAEPA-----------------TVISDTAVND---SRWHTVTIRRNFKNTTLMVDNEIKWVEV-----MSKRRDMTVFSHLFVGGIPPELRSVALRLTSAAVKDEPPFAGWITDVTVNNTE-----CAIINSEGVLMDIC-GTANMCQNGGICSLIDNEPTCDCSHTGFQGKDCSEEDNYTEGLAHLMMGDQDRIKGKEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNDWHDVKVTRNLRQHSGIGHAMVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTV-AFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVDFQRDGRSGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDVRRLAEIQKATGVKPSCSKEPSKQ----CLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSYDGSKFMKVQLPVVMHTEAEDVSLRFRSQRAYGILIATTSRDSADTLRLE--LDSGRVRLTVNLDCIRINCTSSKGPETIFAGQNLNDNEWHTVRVFRRGKSLKLTVDD------------------LSPIEGQMAGDHTQLEFHN---IETGIVTEKRFMSTVPSNFIGHLQSLSFNGMSYIDLCKNGDIDYCELNAMIGFKNIIAD-PVTFKSRSSYVTLTTLQAYYSMHLFFQFKTTSPDGLILYNSGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNKPLSDNQWHNVIISRDTNNLHTVKI-------DTKITTQTTTGAKNLDLKGNLYIGGVAKD--MYMYLPKLVHAKEGFQGCLASVDLNGRL--------PDLMSDALDCVGQIERGC----EGPSTTCQEDSCANQGVCLQQWEGFSCDCSMTTFGGPLCNDAGTTYIFGRDGGLITYTWPPNDRPSTRADRLAIGFSTHL-KDAVLVRVDSSSGLGDFLKLHI----DKGKVAVVFNVGTDDINIEEKAKFVNDGKYHIVKFTRSGGNATLQVDDLPVNERYPTGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQTTIQIGGWERDRSQSFQGQLSGLYYNGLKVFNMAAEGDSNVKIQGSVRLVGDSPSSITPQSSTTANRSETSTSIMEITTTTASSRRVKQTTPREPQ--QTTDDFLVASAECP--SDDEDIDPCEPSSGGLANP--TFAGPNPPE 1398 HSP 2 Score: 156.762 bits (395), Expect = 7.063e-38 Identity = 194/921 (21.06%), Postives = 369/921 (40.07%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTY--FSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN----------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMEN-------QFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN--------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK---------MHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLL----TIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLS--------DRIHVP-DGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT S L+ Y +G DF + IR+ L + + V+S+ V++ H + + +++D E + + + D+ L++G + ++ SV+ + S + F+G I +T++++ + I + C T+ N+C N GIC + ++ +CDC+ T F G C+ KE +A F G +F N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + ++ + M I + ++ + + Q+ + L S+D ++G + FMG + +Y + LAK+ P + I T + + NV I F + +S++V+ K N + F +T +P+GLLLF G+ D+ +EM+ G L+++ + GSG + + + +NDG W+ V F+ DG+ + +NT + G+ ++LGG EN+ + F E T G+ GCI +++ KD+ L E + V +C + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + LI+ S L + +++ + I++ ++ G + + N+ D +H VR + + L +DDLS D + I+ V ++ M+ V S +F G + L+ N ++ +D K
Sbjct: 28 LEFTGAEGQWARFPVWNACCESEMSFNMKTKSSHGLLVY--FDDEGF---CDFLELLIRNGKLSLRFSIFCAEPATVISDTAVNDSRWHTVTIRRNFKNTTLMVDNEIKWVEVMSKRRDMTVFSHLFVGGIP-PELRSVALRLTSAAVKDEPPFAGWITDVTVNNTECAI---INSEGVLMDICGTA------NMCQNG----GICSLIDNEPTCDCSHTGFQGKDCSEEDNYTEGLAHLMMGDQDRIKGKEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNDWHDVKVTRNLRQ------------HSGIGHAMVTISVDGILTTTGY-----TQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTVAFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVD------------FQRDGR----SGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQ--------SKDVRRLAEIQKATGVKPSC---SKEPSKQCLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSY-DGSKFMKVQLPVVMHTEAEDVSLRFRSQ-RAYGILIATTSRDSADTLRLELDSGRVRLTVNLDCIRINCTSSKGPETIFAGQ-NLNDNEWHTVRVFRRGKSLKLTVDDLSPIEGQMAGDHTQLEFHNIETGIVTEKRFMSTVPS-------NFIGHLQSLSFNGMSYIDLCK 865
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Match: ENSORLT00000045162.1 (neurexin 1 [Source:NCBI gene;Acc:101159771]) HSP 1 Score: 315.464 bits (807), Expect = 2.955e-87 Identity = 287/1221 (23.51%), Postives = 514/1221 (42.10%), Query Frame = 2
Query: 755 KYEYL-TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY-------QPSSKKGIHT-DTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNF---------GRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSG-YKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANE-KHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM--------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN-----FNSYILLINKSNADLVP--NFQPRRSDQSL-------------KQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQE 4171
K EY+ TF + Y ++ I + I FKT Q N + + G ++++ +++G ++I+ +F N + D+ WH+V++ + I++D Q+++ L + F P LP P + F GC+KE+ N+V L + + + +G + + C + + P++F ++ + + S F+T + + L+ + QP K T DF++IE+ + LY + + S N V++G +++ + I ++ ++ + +LY+G L + K+ L VW+ +L + GCI L ID + L I+K + + C C + PC N GIC+ W++ CDC+ T + G +C +EA I ++G +FM+++ P +E E+ L F+S+ G++++T ++ S T +LE + +G + + +N +G + +N D++WH++++ RR K+LK+ +DD I G + T ++ + + I+ + F+G++ +NG +Y +L K EL A + N++ + F S SY+ + + + L FQ KT P GL+L+ G+ ND++++E+V G LH + + G+G + K + + L+D WH+V I R + H+ D++ TG N + G +++GG ++ + + + +K GFQGC+AS +N + DL+ +A + ++ C C DSC+ G C Q W +SCDCS T+F GP C D TT F + + Y + + S ++LA GF T+ K A L+ + + L L + I D G + V + T + E V DG YHIV+F + ATL++DDL P G + N VVDE L+ +G E SFQG +SGL N + + + E + L+ S + + P + RS+ S + + P+ P+ Q + +VA +CP ++ E + G+ P F PN E
Sbjct: 275 KEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK-----------SADYVNLALKNGAVSLVINLGSG---AFEALVEPVNGKFN---DNDWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTV-AFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVDFQRDGRSGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQSKDVRRLAEIQKATGVKPSCSKEPSKQ----CLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSYDGSKFMKVQLPVVMHTEAEDVSLRFRSQRAYGILIATTSRDSADTLRLE--LDSGRVRLTVNLDCIRINCTSSKGPETIFAGQNLNDNEWHTVRVFRRGKSLKLTVDD------------------LSPIEGQMAGDHTQLEFHN---IETGIVTEKRFMSTVPSNFIGHLQSLSFNGMSYIDLCKNGDIDYCELNAMIGFKNIIAD-PVTFKSRSSYVTLTTLQAYYSMHLFFQFKTTSPDGLILYNSGDGNDFIVVELVKGYLHYVSDLGNGAHLIKGNSNKPLSDNQWHNVIISRDTNNLHTVKI-------DTKITTQTTTGAKNLDLKGNLYIGGVAKD--MYMYLPKLVHAKEGFQGCLASVDLNGRL--------PDLMSDALDCVGQIERGC----EGPSTTCQEDSCANQGVCLQQWEGFSCDCSMTTFGGPLCNDAGTTYIFGRDGGLITYTWPPNDRPSTRADRLAIGFSTHL-KDAVLVRVDSSSGLGDFLKLHI----DKGKVAVVFNVGTDDINIEEKAKFVNDGKYHIVKFTRSGGNATLQVDDLPVNERYPTGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQTTIQIGGWERDRSQSFQGQLSGLYYNGLKVFNMAAEGDSNVKIQGSVRLVGDSPSSITPQSSTTANRSETSTSIMEITTTTASSRRVKQTTPREPQ--QTTDDFLVASAECP--SDDEDIDPCEPSSGGLANP--TFAGPNPPE 1406 HSP 2 Score: 154.451 bits (389), Expect = 4.180e-37 Identity = 195/931 (20.95%), Postives = 367/931 (39.42%), Query Frame = 2
Query: 1403 VSFTGKSDYLQAFGI-RSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTY--FSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCN--------------------------------------KEAIIAEFNGYQFMRIKFP-NTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG---------NKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIK-YLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRN----YFELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESN--------------DYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGK---------MHLGGYLENQSIVTFDNE--TPRSKGGFQGCIASFYVNNSVSTDTVILYKDL--LKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLL----TIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLS--------DRIHVP-DGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLK 3904
+ FTG F + + +++ S + KT S L+ Y +G DF + IR+ L + + V+S+ V++ H + + +++D E + + + D+ L++G + ++ SV+ + S + F+G I +T++++ + I + C T+ N+C N GIC + ++ +CDC+ T F G C+ KE +A F G +F N +S + L FK+ NGL+L T + D + + ++NG++ +++N G G N KF D+ WH +K+ R + + + +D + + D ++G + +G + D VSN+ FMG + +Y + LAK+ P + I T + + NV I F + +S++V+ K N + F +T +P+GLLLF G+ D+ +EM+ G L+++ + GSG + + + +NDG W+ V F+ DG+ + +NT + G+ ++LGG EN+ + F E T G+ GCI +++ KD+ L E + V +C + C + C G C + W +Y CDCS T + G CE +T + ++ + ++ ++ F++ R + LI+ S L + +++ + I++ ++ G + + N+ D +H VR + + L +DDLS D + I+ V ++ M+ V S +F G + L+ N ++ +D K
Sbjct: 28 LEFTGAEGQWARFPVWNACCESEMSFNMKTKSSHGLLVY--FDDEGF---CDFLELLIRNGKLSLRFSIFCAEPATVISDTAVNDSRWHTVTIRRNFKNTTLMVDNEIKWVEVMSKRRDMTVFSHLFVGGIP-PELRSVALRLTSAAVKDEPPFAGWITDVTVNNTECAI---INSEGVLMDICGTA------NMCQNG----GICSLIDNEPTCDCSHTGFQGKDCSEEDNYTEGLAHLMMGDQDRIKGQRGEAWLLRSLLSTPGKEEYVATFKGSEFFCYDLSLNPIQSSSDEITLSFKTLQRNGLMLHTGK----SADYVNLALKNGAVSLVINLGSGAFEALVEPVNGKFN------DNDWHDVKVTRNLRQVTISVD-GILTTTGYTQEDYTMLGSDDFFYVGGS----PSTADLPGSPVSNN--------------FMGCLKEVVYKNNDVRLELSRLAKQGDPKMKIHGTVAFKCENVATLDPITFETPESFIVLNKWNAKKTGSISFDFRTTEPNGLLLFSHGKPKQQPKDSKSPQTFKVDFFAIEMLEGHLYLLLDMGSGTTKTKAVNKKVNDGEWYHVD------------FQRDGR----SGTISINTLRTAYTAPGESEILDLDDNLYLGGLPENKMGLVFPTEVWTALLNYGYVGCIRDLFIDGQ--------SKDVRRLAEIQKATGVKPSC---SKEPSKQCLSNPCQNNGICREGWNRYVCDCSGTGYLGRSCEREATILSY-DGSKFMKVQLPVVMHTEAEDVSLRFRSQ-RAYGILIATTSRDSADTLRLELDSGRVRLTVNLDCIRINCTSSKGPETIFAGQ-NLNDNEWHTVRVFRRGKSLKLTVDDLSPIEGQMAGDHTQLEFHNIETGIVTEKRFMSTVPS-------NFIGHLQSLSFNGMSYIDLCK 873
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Match: ENSORLT00000036135.1 (neurexin-2 [Source:NCBI gene;Acc:101165088]) HSP 1 Score: 314.309 bits (804), Expect = 8.057e-87 Identity = 319/1351 (23.61%), Postives = 552/1351 (40.86%), Query Frame = 2
Query: 155 LSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYL---TCIIDLSKIDGLIHEWHTIMI--NFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAI--EPSFSGRISAVRIVRFSRLYLIPVMIQFQS---DAMNTCYFDS-----NFC------------------RYCSSS------------------KKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTD----TDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSL-DDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLL--IKKNSSISSGCKTSEEMH---SLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYK-RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEK-HYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNT---------------VVDEELM------------AIVGSSEVSSKNSFQGFISGLTINEIAILDTLKEN 3910
LSF +K + L+ Y +D F+ L L+ RL + H + P +L T + D WH +M+ N+ + +++ + + +V KR + + ++ GG+ ++ A SS + EP F G IS +++ +P+++ Q+ D C DS C RYC+ ++ K TF N + I I F+T Q N L + G + ++ + + G F ++ P S KFH D+ WH+V++ + I +D Q+++ L + L ++ + T LP P + F GC+K++ N L + + ++ +G L C + ++PV+F S +L + + S F+T + L+ + S G D DF+++E+ D LY + + S S+ + NG ++ + I ++ +N + ++ +G +++G L ++ + L + VW+ LG F GC+ L ID L L ++ + +SS C ++E H S + CAN G C+ W++ CDC+ T + G +C KEA ++G ++++ P T +E E+ L F S+ GL+L+T +Q S D L + + G + + +N G+G + E D++WH++K+ RR KNL++ +D+ E + + G + + + G + +V ++ F+G++ +NG Y + K EL A +++ + F + SYL + + L FQ KT P GL+LF G+ +D++++E+V G +H +++ G+G K + LND LWH+V I R + H DSR G N + G++++GG +S+ + S+ G++GC+AS +N + DLL +A K V+ C C+ DSC G C Q W +SCDC+ T++ GP C D TT F K + + Y ++ ++ S ++LA GF T +K A L+ + T L L + I D G I V + T + E + V DG YH+VRF + ATL++D+ P G N VVDE L+ A + FQG ISGL N + +L E+
Sbjct: 47 LSFILKTNITKALVLYLDDGGNCDFLELLLVDG---RLQLRFTIHCA-------------EPAFLHTETYVND--------QRWHRVMLTRNYRETRLVVDNEEKTAEVK-------SKRKEMVVASDLYVGGISPDVRLSA----LTSSTVKYEPPFQGFISNLKVGE-----ALPILLDGQAVHNDLEYICATDSPCSNKGICSINQGEVLCNCISTSYRGRYCNEVVQKEVEGLAHLMLNRQVYRQGQKESVATFRGNEFFSFNLSQTPIQSNLDEITLSFRTLQRNGLLLHTGRSADYVNLSLRNGALWLVINLGSGAFEALV-EPAS-------GKFH---------DNVWHDVRVTRNLRQVTILVDGILTTTGYTQEDYTMLGSDDL---FYIGGSLNT--------ADLPGSPVSNNFMGCLKDVIYKNNEFRLELSRLAEQRDPKISIHGDLVFS-CENVEALEPVTFDTPSAFLTLPRWNTKKTGAISFDFRTSEPSGLLLFSHGSLHGAQPDRKPRADFFAVELLDGFLYLVMDMGSGSIKVKASDKRLDNGEWCHVDFQRKGRSGFISVNSQNIPFTANEGSEILDLDGDMFLGGLPEERQSLILPPEVWTASLGLGFVGCVRDLFIDGQSRNLWRLAEVQIAAGVSSFC--TKETHVRCSRDTCANG----GHCREGWNRHICDCSGTGYLGPSCGKEATTVGYDGSMYLKVGLPRTMHTEAEDVSLRFMSQRAFGLLLATTSQQS--ADTLRVELDAGRVKLTVNLGKGPETLLVGEKLNDNEWHTVKVARRGKNLQLSVDNVTAEGH--------MTGAHTRLEFNNIETGIMTERRFISVVPSN--------------FIGHLQALSFNGMLYLDQCKNGDISYCELNARFGLRHIIAN-PVTFLTQASYLAFSTLQAYASMHLFFQFKTTSPDGLILFNSGDGSDFIVVEIVKGYIHYVFDLGNGPSLMKGNSDRPLNDNLWHNVVISRDNNNVHVLKI-------DSRTVTQHANGARNLDLKGELYIGGV--GKSMYSSLPRLIASREGYKGCLASVDLNGRL--------PDLLADALHKVGDVERGC----GGPSTTCTEDSCHHQGVCLQQWEGFSCDCTMTTYGGPFCSDPGTTYIFGKGGALITYTWAPNERPSTRADRLAVGFSTQ-QKDAILVRVESTHGLGDYLQLHI----DQGKIGVIFNVGTDDITIDEPAVIVNDGKYHVVRFTRSGGNATLQVDNHPVIERYPPGHYDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGQDKGRPFQGQISGLYYNGLQVLKLAAES 1271 HSP 2 Score: 154.451 bits (389), Expect = 4.161e-37 Identity = 195/887 (21.98%), Postives = 356/887 (40.14%), Query Frame = 2
Query: 1463 AKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLD-DTKILSVSHHVWSGILGTYFSGCIFSLTIDDS-PIQLDLLIKKNSSISSGCKTSEEMHSLNVCA-NQPC-NEGICQIEWDQRSCDCTKTNFTGNTCN-----------------------KEAIIAEFNGYQFMRIKFPNT-YKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENC-----FDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLI-IGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYF----ELAKKLSP-LNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGE----------SNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVP--VNTGGLNFNHFGKMHLGGYLE-NQSIVTFDNETPRSKG-GFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENY--CSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFM-ESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG--------IDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILL 3931
+ S KT+ + L+ Y + DF + + D L ++ + + + V++ H ++L R+++D E + + ++ LY+G + D ++ +++ F G I +L + ++ PI LD G ++ +CA + PC N+GIC I + C+C T++ G CN ++ +A F G +F T +S ++ L F++ NGL+L T + D + + ++NG++++++N G G F+ L D+ WH +++ R + + + +D + + D ++G L IG + N D+ S VSN+ FMG + IY + LA++ P ++I NV + F + ++L +P+ N + F +T +PSGLLLF G D+ +E+++G L+++ + GSG + + L++G W V R K S V+ + ++P N G + G M LGG E QS++ S G GF GC+ +++ L++ L E V C KE + CS D+C+ GG C + W ++ CDCS T + GP C +TT + YL ++ F + R F L++ QS L ++ D G +++ G + + +LN D +H V+ + L +D+++ H+ I+ + + +++V S +F G + L+ N + LD K SY L
Sbjct: 45 GELSFILKTNITKALVLYLDDGG-----NCDFLELLLVDGRLQLRFTIHCAEPAFLHTETYVNDQRWHRVMLTRNYRETRLVVDNEEKTAEVKSKRKEMVVASDLYVGGISPDVRLSALTSSTVK--YEPPFQGFISNLKVGEALPILLD-----------GQAVHNDLEY--ICATDSPCSNKGICSINQGEVLCNCISTSYRGRYCNEVVQKEVEGLAHLMLNRQVYRQGQKESVATFRGNEFFSFNLSQTPIQSNLDEITLSFRTLQRNGLLLHTGR----SADYVNLSLRNGALWLVINLGSG--AFEALVEPASGKFHDNVWHDVRVTRNLRQVTILVD-GILTTTGYTQEDYTMLGSDDLFYIGGSL-NTADLPGSP---VSNN--------------FMGCLKDVIYKNNEFRLELSRLAEQRDPKISIHGDLVFSCENVEALEPVTFDTPSAFLTLPRWNTKKTGAISFDFRTSEPSGLLLFSHGSLHGAQPDRKPRADFFAVELLDGFLYLVMDMGSGSIKVKASDKRLDNGEWCHVDFQR---KGRSGFISVNSQ------NIPFTANEGSEILDLDGDMFLGGLPEERQSLILPPEVWTASLGLGFVGCVRDLFIDGQSRN----LWR--LAEVQIAAGVSSFC-----TKETHVRCSRDTCANGGHCREGWNRHICDCSGTGYLGPSCGKEATTVGY-DGSMYLKVGLPRTMHTEAEDVSLRFMSQ-RAFGLLLATTSQQSADTL-----RVELDAGRVKLTVNLGKGPETLLVGEKLN--DNEWHTVKVARRGKNLQLSVDNVTAEGHMTGAHTRLEFNNIETGIMTERRFISVVPS-------NFIGHLQALSFNGMLYLDQCKNGDISYCEL 850
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Match: nrxn3b (neurexin-3b [Source:NCBI gene;Acc:101156134]) HSP 1 Score: 311.227 bits (796), Expect = 1.359e-85 Identity = 306/1270 (24.09%), Postives = 523/1270 (41.18%), Query Frame = 2
Query: 134 NVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIE-PSFSGRISAVRI---------VRFSRLYLIPVMIQFQSDAMNTCYF--DSNFC---------RYCSSSKKCTKYEYL------TFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFY---TRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDF-------QKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDI---CMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAY---QPSSKKGI----HTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKI-LSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKN--SSISSGCKTSEEMHSLNVCANQPC-NEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYK-RKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPR---SKGGFQGCIASFYVNNSVSTDTVILYKDLLKEAN-EKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSI--NQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDG 3769
+ ++ S L+FQ K GL+ Y +D F+ L LS K++L V + ++T + M + WH IN L + + + + F + D +F GGLPE ++ A + S E P+F G IS + + RL +I + + + C +C RYC+ K+ L TF + Y + I + I FKT Q N L + G ++++ ++DG ++I+ + RKF+ D+ WHN+++ + I++D Q+++ L + F P LP P + F GC++E+ N++ L + + KL DI C + + P++F +L + R S F+T + + LI + +P ++ + DF+++E+ D AL+ + + S + V++ +++ + + I ++ S ++ EG LY+G L + L + +W+ +L + GCI L ID + + + + I C H C + PC N G C+ W++ CDCT T F +TC +EA I F+G +M++ PN +E E+ L F S+ GL+++ ++ S T +LE + +G + + +N G+G + E D++WHS+++ RR KN K+ +D++ E + +I I + I + F + I SS QFF +NG Y ++ K EL A ++ + F + SYL + + + L FQ KT P G +LF G+ ND++ +E+V G +H +++ G+G K + LND WH+V I R S TH+ +VD K + + G N + G + +GG N + N P+ S+ GFQGC+A+ +N + DL+ +A ++ C C DSC+ G C Q W ++CDCS TS++G C D TT F K + Y + ++ S ++LA GF T T L+ I L+ + + I + G + V + T S E+ V DG YH+VRF ++ ATL++D+ H P G
Sbjct: 40 DASSTSDLTFQFKTSASEGLLLYFDDGGYCDFL-LLTLSEGKLQLRVSIDCAETTITSAKMVND---------------------SRWHFAAINRENLRTGLAVDGQTRTGEV----RPQRHFMKIVSD-LFLGGLPEDIRMSA---ITLPSVCELPAFRGVISDLSYGSKLPTLINSQKVRLEMIGLCTENPCENGGICSLADGETYCDCSRTGYVGRYCTEGKRAEGTVKLREENVATFRGSEYFCYDLSQNPIQSSSDEITLSFKTWQRNGLLLHTGK-----------SADYVNLALKDGAVSLVINLGSGAFEAIVEPVNRKFN---------DNSWHNIKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDF-------FYVGGSP----STADLPGSPVSNNFMGCLQEVVYKNNDIRLELSRLARID----DPKMKLQGDIVFECENVPTLDPINFETPDSFLALPKWNTKRVGSISFDFRTTEPNGLILFTQGRPQDRRDAKGQKNNKVDFFAVELLDGALFLLLDMGSGTIKVKATQAKVNDDAWYHVDIQRDGRSGIISVNSHRTPFTASGENEILDLEGDLYLGGLPYNRAGLVLPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQIAQMQNITDIKFSCSKITGKH----CDSSPCKNNGACREGWNRFVCDCTGTGFWDSTCEREASILSFDGTMYMKVVMPNVMHTEAEDVSLRFMSQRAFGLLMAASSRESADTLRLE--LDSGRVKLTVNLGKGPEVLYAGEKLNDNEWHSVRVVRRGKNFKLIVDEDMAE-------GIAVIAIIWCSIYNVFSSLKRIVVSS-------------------QFFHFQSNSLKFNGMQYIDMCKNGDIDFCELNARFGMRFIIAD-PVTFKTKASYLGLATLQAYTTMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGFIHYVFDLGNGPSLLKGNSDSPLNDNQWHNVVITRDASNTHT--LKVDSKSVNQNVN-----GAKNLDLKGDLFIGGLGPNM----YQN-LPKLVVSREGFQGCLATVDLNGRL--------PDLISDALFRSGQIERGC----EGPSTTCQEDSCANMGVCIQQWENFTCDCSMTSYTGTYCNDPGTTYIFGKGGGLITYTWPNNERPSTRADRLAVGFST-TINDGILVRIDSASGLADFIMLHI----EQGKVGVTFNIGTVDISVKETSTVVNDGKYHLVRFTRNGGNATLQVDNWPINEHFPSG 1182
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Match: SMESG000066308.1 (SMESG000066308.1) HSP 1 Score: 3089.67 bits (8009), Expect = 0.000e+0 Identity = 1519/1528 (99.41%), Postives = 1521/1528 (99.54%), Query Frame = 2
Query: 17 MSLTNMQNXXXXXXXXXXXXXEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCS SKKCTKYEYLTFDHNSEIGYAFPVDV SEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFT SDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRI+LDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNS+STDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELM IVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSN DLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGG FMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV
Sbjct: 1 MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSLSKKCTKYEYLTFDHNSEIGYAFPVDVNSEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRIILDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSISTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMVIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNVDLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGTFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 1528
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Match: SMESG000066308.1 (SMESG000066308.1) HSP 1 Score: 3076.19 bits (7974), Expect = 0.000e+0 Identity = 1514/1523 (99.41%), Postives = 1516/1523 (99.54%), Query Frame = 2
Query: 32 MQNXXXXXXXXXXXXXEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
MQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCS SKKCTKYEYLTFDHNSEIGYAFPVDV SEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFT SDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRI+LDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNS+STDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELM IVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSN DLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGG FMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV
Sbjct: 1 MQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSLSKKCTKYEYLTFDHNSEIGYAFPVDVNSEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRIILDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSISTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMVIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNVDLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGTFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 1523
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Match: SMESG000066308.1 (SMESG000066308.1) HSP 1 Score: 3019.18 bits (7826), Expect = 0.000e+0 Identity = 1493/1528 (97.71%), Postives = 1495/1528 (97.84%), Query Frame = 2
Query: 17 MSLTNMQNXXXXXXXXXXXXXEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCS SKKCTKYEYLTFDHNSEIGYAFPVDV SEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFT SDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRI+LDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFN IQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNS+STDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELM IVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSN DLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGG FMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV
Sbjct: 1 MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSLSKKCTKYEYLTFDHNSEIGYAFPVDVNSEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRIILDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFN--------------------------IQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSISTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMVIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNVDLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGTFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 1502
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Match: SMESG000066308.1 (SMESG000066308.1) HSP 1 Score: 3007.24 bits (7795), Expect = 0.000e+0 Identity = 1488/1523 (97.70%), Postives = 1490/1523 (97.83%), Query Frame = 2
Query: 32 MQNXXXXXXXXXXXXXEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMAIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNADLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGAFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTXXXXXXXXXXXXCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 4600
MQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCS SKKCTKYEYLTFDHNSEIGYAFPVDV SEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFT SDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRI+LDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFN IQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNS+STDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELM IVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSN DLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGG FMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV
Sbjct: 1 MQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSLSKKCTKYEYLTFDHNSEIGYAFPVDVNSEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRIILDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFN--------------------------IQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGESNDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGGFQGCIASFYVNNSISTDTVILYKDLLKEANEKHYVDENCPDNHNDKENYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDDLSDRIHVPDGIDQNTVVDEELMVIVGSSEVSSKNSFQGFISGLTINEIAILDTLKENFNSYILLINKSNVDLVPNFQPRRSDQSLKQSEEEPKNPETNQKNNRIVVARPQCPGITEAEKFQCQQYHYKGIVKPGVAFKKPNTQEKHSKTNFEEFASRSTNKPFEYLLPNNDQTTSDFNINNMKINPKNENTIKSNLNINIWLIAAFSCGGTFMLIALSCLIYRCSTKDEGSYNVKEDRICIQTNLNSSKLKSKLNCDEKSNQSLLTKIPNKRKSKRKRSGETKEWYV 1497
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Match: SMESG000066308.1 (SMESG000066308.1) HSP 1 Score: 1662.89 bits (4305), Expect = 0.000e+0 Identity = 821/827 (99.27%), Postives = 822/827 (99.40%), Query Frame = 2
Query: 17 MSLTNMQNXXXXXXXXXXXXXEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSSSKKCTKYEYLTFDHNSEIGYAFPVDVISEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTGKSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRILLDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTDI 2497
MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCS SKKCTKYEYLTFDHNSEIGYAFPVDV SEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFT SDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRI+LDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGT I
Sbjct: 1 MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQIKIDTLMGLIFYAEDIKTNSFVSLKLLSSAKVRLDVGLFYHDSTRENISMSKEYPTAPDYLTCIIDLSKIDGLIHEWHTIMINFHKKSIILQFNQFSEKVNIPIGYNSFKRFDGFLGDTMFFGGLPEKLKQDASHRVFFSSAIEPSFSGRISAVRIVRFSRLYLIPVMIQFQSDAMNTCYFDSNFCRYCSLSKKCTKYEYLTFDHNSEIGYAFPVDVNSEINRSINFQFKTKQDNSFLFYIGSLPGLAEQFQISKTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGKLNSDICMEMFPIKPVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHNIVLHFELPVIRIILDKENYVLNISTNYHDIEFEGSLYIGSLDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSPIQLDLLIKKNSSISSGCKTSEEMHSLNVCANQPCNEGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGYQFMRIKFPNTYKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKFKTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMPIIGIKYLIIGSAFDNGTGI 827 HSP 2 Score: 62.3882 bits (150), Expect = 3.128e-9 Identity = 109/552 (19.75%), Postives = 220/552 (39.86%), Query Frame = 2
Query: 2141 YKSEVENFYLMFKSKLPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRG------NKKF---KTLENCFDDKWHSIKMKRRRKNLKVWIDDNYYEFNNFLEMDMP-IIGIKYLIIGSAFDNGTDIQDSSSKLVSNDIIHLGKVKRMENQFFMGYMMHFIYNGRNYFELAKKLSPLNIELTASLQPANVMRQFAINFHSTKSYLVIPKVNIFGDFRLEFQMKTLQPSGLLLFLQGES------NDYLILEMVNGLLHIIYNWGSGYKRKISESGLLNDGLWHSVKIVRHMSKTHSFAFRVDGKPDDSRADVPVNTGGLNFNHFGKMHLGGYLENQSIVTFDNETPRSKGG--FQGCIASFYVNNSVSTDTVILYKDLLKEANEKHYVDENCPDNHNDKE-NYCSIDSCSFGGKCTQHWMKYSCDCSSTSFSGPKCEDVSTTAQFVKHPSYLVYKYSIIKKHSINQLAFGFQTNTRKFAPLISIIGTQSLSPLLTIEIKIVNDYGFIQVEYYTNTGTHSFMESRLNVIDGLYHIVRFRKDRMAATLKLDD 3739
+K++ +N +L + LP L+ Q Q S T + +++++G +I+++ + +KF + C DDKWH++++K R ++ + +DD EF N + I +K+ F Q +S + ++ +N + + N+ K LN ++ + P ++F YL + + KT + L+ + D+ +E+ + L+ S K+ + +++GL H+ IV H R+ ++ ++ N + F G +++G L++ I++ + G F GCI S +++S + DLL + N + C + N C+ C+ G C W + SCDC+ T+F+G C + A+F + ++ K+ K + F++ P I+ TQ+ T +++I G I + G F ++ N D +H ++ ++ R + +DD
Sbjct: 279 FKTKQDNSFLFYIGSLPG---LAEQFQIS-KTQFISVYIEDGLFHIIISNPQSVDSSFYTRKFHCNSIYKTCADDKWHNVQIKEFRNDIVITLDDFQKEFKNLSNQQLTKTIHMKFAKATEPFQYYRQTQLPQYPPLSQFRGCMKEIYLHQNNVTLNIVEMVTKKVYNFHSNGK----LNSDICMEMFPIK-----PVSFTRNSDYLQAFGIRSVRKAKFSLSFKTHKSDCLIAYQPSSKKGIHTDTDFYSIEIRDFALYFSIGLNSVVYSKVMSNYNVSNGLLHN--IVLHFELP---VIRIILDKENYVLNISTNYHDIEFE--GSLYIGS-LDDTKILSVSHHVWSGILGTYFSGCIFSLTIDDSP------IQLDLLIKKNSS--ISSGCKTSEEMHSLNVCANQPCN-EGICQIEWDQRSCDCTKTNFTGNTCNKEAIIAEFNGY-QFMRIKFPNTYKSEVENFYLMFKSK----LPNGLILSTQNQFSGTTDKLEIFMQNGSIYILLNFGRGNKKF-KTLENCFDDKWHSIKMKRRRKNLKVWIDD 794 The following BLAST results are available for this feature:
BLAST of neurexin-1 isoform X16 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46) Total hits: 0
BLAST of neurexin-1 isoform X16 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99) Total hits: 5
BLAST of neurexin-1 isoform X16 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST) Total hits: 5
Analyses
This transcript is derived from or has results from the following analyses Sequences
The following sequences are available for this feature:
transcript sequence >SMED30018208 ID=SMED30018208|Name=neurexin-1 isoform X16|organism=Schmidtea mediterranea sexual|type=transcript|length=4755bpback to top protein sequence of SMED30018208-orf-1 >SMED30018208-orf-1 ID=SMED30018208-orf-1|Name=SMED30018208-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=1529bp MSLTNMQNIFIFILIISSKKSEFQIFIGISALSVYHPSINVNTNSSLSFQback to top Annotated Terms
The following terms have been associated with this transcript:
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
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