Lysosome-associated membrane glycoprotein 2

Overview
NameLysosome-associated membrane glycoprotein 2
Smed IDSMED30018188
Length (bp)1009
Neoblast Clusters

Zeng et. al., 2018



▻ Overview

▻ Neoblast Population

▻ Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

 

Overview

 

Single cell RNA-seq of pluripotent neoblasts and its early progenies


We isolated X1 neoblasts cells enriched in high piwi-1 expression (Neoblast Population), and profiled ∼7,614 individual cells via scRNA-seq. Unsupervised analyses uncovered 12 distinct classes from 7,088 high-quality cells. We designated these classes Nb1 to Nb12 and ordered them based on high (Nb1) to low (Nb12) piwi-1 expression levels. We further defined groups of genes that best classified the cells parsed into 12 distinct cell clusters to generate a scaled expression heat map of discriminative gene sets for each cluster. Expression of each cluster’s gene signatures was validated using multiplex fluorescence in situ hybridization (FISH) co-stained with piwi-1 and largely confirmed the cell clusters revealed by scRNA-seq.

We also tested sub-lethal irradiation exposure. To profile rare pluripotent stem cells (PSCs) and avoid interference from immediate progenitor cells, we determined a time point after sub-lethal irradiation (7 DPI) with minimal piwi-1+ cells, followed by isolation and single-cell RNA-seq of 1,200 individual cells derived from X1 (Piwi-1 high) and X2 (Piwi-1 low) cell populations (Sub-lethal Irradiated Surviving X1 and X2 Cell Population)



Explore this single cell expression dataset with our NB Cluster Shiny App



 

Neoblast Population

 

t-SNE plot shows two-dimensional representation of global gene expression relationships among all neoblasts (n = 7,088 after filter). Cluster identity was assigned based on the top 10 marker genes of each cluster (Table S2), followed by inspection of RNA in situ hybridization patterns. Neoblast groups, Nb.


Expression of Lysosome-associated membrane glycoprotein 2 (SMED30018188) t-SNE clustered cells

Violin plots show distribution of expression levels for Lysosome-associated membrane glycoprotein 2 (SMED30018188) in cells (dots) of each of the 12 neoblast clusters.

 

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Sub-lethal Irradiated Surviving X1 and X2 Cell Population

 

t-SNE plot of surviving X1 and X2 cells (n = 1,039 after QC filter) after sub-lethal irradiation. Colors indicate unbiased cell classification via graph-based clustering. SL, sub-lethal irradiated cell groups.

Expression of Lysosome-associated membrane glycoprotein 2 (SMED30018188) in the t-SNE clustered sub-lethally irradiated X1 and X2 cells.

Violin plots show distribution of expression levels for Lysosome-associated membrane glycoprotein 2 (SMED30018188) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells.

 

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Embryonic Expression

Davies et. al., 2017

Hover the mouse over a column in the graph to view average RPKM values per sample.
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Embryonic Stages: Y: yolk. S2-S8: Stages 2-8. C4: asexual adult. SX: virgin, sexually mature adult.
For further information about sample preparation and analysis for the single animal RNA-Seq experiment, please refer to the Materials and Methods

 

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Anatomical Expression

PAGE et. al., 2020



SMED30018188

has been reported as being expressed in these anatomical structures and/or regions. Read more about PAGE



PAGE Curations: 8

  
Expressed InReference TranscriptGene ModelsPublished TranscriptTranscriptomePublicationSpecimenLifecycleEvidence
intestinal phagocyteSMED30018188h1SMcG0018828 Contig1891GPL15192PMID:23079596
Forsthoefel et al., 2012		FACS sorted cell population asexual adult cDNA to DNA expression microarray evidence
Smed sexual biotypeSMED30018188h1SMcG0018828 Contig41694uc_Smed_v2PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018188h1SMcG0018828 Contig41694newmark_estsPMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
Smed sexual biotypeSMED30018188h1SMcG0018828 Contig1891GPL15192PMID:29674431
Fincher et al., 2018		FACS sorted cell population adult hermaphrodite single-cell RNA-sequencing evidence
protonephridiaSMED30018188h1SMcG0018828 dd_Smed_v4_722_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
gutSMED30018188h1SMcG0018828 dd_Smed_v4_722_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
cephalic gangliaSMED30018188h1SMcG0018828 dd_Smed_v4_722_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
parenchymal cellSMED30018188h1SMcG0018828 dd_Smed_v4_722_0_1dd_Smed_v4PMID:29674431
Fincher et al., 2018		FACS sorted cell population asexual adult single-cell RNA-sequencing evidence
Note: Hover over icons to view figure legend
Homology
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Human
Match: LAMP1 (lysosomal associated membrane protein 1 [Source:HGNC Symbol;Acc:HGNC:6499])

HSP 1 Score: 59.6918 bits (143), Expect = 2.332e-9
Identity = 29/70 (41.43%), Postives = 43/70 (61.43%), Query Frame = 1 
Query:  601 VKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            V I  +  Q F+ +   G   GS +EC++D     ++P+ VGG L G+++IV+I YL+GR R  A YQTI
Sbjct:  352 VNIFKVWVQAFKVE---GGQFGSVEECLLDE-NSMLIPIAVGGALAGLVLIVLIAYLVGRKRSHAGYQTI 417
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Match: lamp1b (lysosomal associated membrane protein 1b [Source:ZFIN;Acc:ZDB-GENE-030131-9303])

HSP 1 Score: 64.3142 bits (155), Expect = 1.863e-11
Identity = 36/94 (38.30%), Postives = 56/94 (59.57%), Query Frame = 1 
Query:  529 TLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            TL   ++C K  TL+  +N +   +    LQ Q F  K   GD+ G+ +EC +D  +  ++P++VG  L  +++IVI+ YLIGR+R  A YQTI
Sbjct:  168 TLGHSYMCQKEKTLSVTQNFS---LNTFQLQVQPFGVK---GDF-GAAEECELDE-DDMLIPIVVGAALAVLVLIVILAYLIGRNRSHAGYQTI 253
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Match: lamp2 (lysosomal-associated membrane protein 2 [Source:ZFIN;Acc:ZDB-GENE-030729-9])

HSP 1 Score: 59.3066 bits (142), Expect = 1.955e-9
Identity = 54/222 (24.32%), Postives = 105/222 (47.30%), Query Frame = 1 
Query:  151 VVKFYVTNDSLNDACMLLTISAEFN--VQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            V  + V  D+++D C+L  +  +F+  +    S +  N+   + +         +D S  L++  + + +   ++S  + +     H   ++  + N N+    DSN    TNL  W         E ++   ++C K  + N ++   K+ +    LQ Q F  K N+     + +EC +D+    +VP+ VG  L+ +II+V+I+YLIGR + R  YQ++
Sbjct:  162 VGNYSVKTDNVSD-CLLAKMGLQFSFKISGNASLQTVNLDPNVTKVNGTCGSGGSDSSLFLTSKDITVHFVFTNDSQKFRL-----HALTLTVDLGNGNIF--NDSN----TNLSLW---------EASVGSSYMCRKEQSYNISD---KLTLNTFELQVQPFDVKKNS---FSTAEECFLDSDLSFLVPIAVGVALSFLIILVLISYLIGRRKSRTGYQSV 356
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Match: lamp1a (lysosomal associated membrane protein 1a [Source:ZFIN;Acc:ZDB-GENE-030131-3708])

HSP 1 Score: 58.151 bits (139), Expect = 4.539e-9
Identity = 28/65 (43.08%), Postives = 40/65 (61.54%), Query Frame = 1 
Query:  616 LQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            LQ Q F   +N      + +EC +D  E  ++P+IVG  L G+++IV++ YLIGR R  A YQTI
Sbjct:  301 LQLQPFNITANRFS---TAEECRVDQ-ENMLIPIIVGAALAGLVLIVLVAYLIGRKRTHAGYQTI 361
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Match: lamp1a (lysosomal associated membrane protein 1a [Source:ZFIN;Acc:ZDB-GENE-030131-3708])

HSP 1 Score: 57.7658 bits (138), Expect = 5.788e-9
Identity = 28/65 (43.08%), Postives = 40/65 (61.54%), Query Frame = 1 
Query:  616 LQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            LQ Q F   +N      + +EC +D  E  ++P+IVG  L G+++IV++ YLIGR R  A YQTI
Sbjct:  295 LQLQPFNITANR---FSTAEECRVDQ-ENMLIPIIVGAALAGLVLIVLVAYLIGRKRTHAGYQTI 355
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Match: lamp2 (lysosomal-associated membrane protein 2 [Source:ZFIN;Acc:ZDB-GENE-030729-9])

HSP 1 Score: 57.7658 bits (138), Expect = 6.453e-9
Identity = 55/222 (24.77%), Postives = 101/222 (45.50%), Query Frame = 1 
Query:  151 VVKFYVTNDSLNDACMLLTISAEFN--VQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            V  + V  D+++D C+L  +  +F+  +    S +  N+   + +         +D S  L++  + + +   ++S  + +     H   ++  + N N+    DSN    TNL  W         E ++   ++C K  + N ++   K+ +    LQ Q F  K N+     +  EC +D     ++P+IVG  L G+I IV+I Y+IGR R    YQT+
Sbjct:  162 VGNYSVKTDNVSD-CLLAKMGLQFSFKISGNASLQTVNLDPNVTKVNGTCGSGGSDSSLFLTSKDITVHFVFTNDSQKFRL-----HALTLTVDLGNGNIF--NDSN----TNLSLW---------EASVGSSYMCRKEQSYNISD---KLTLNTFELQVQPFDVKKNS---FSTAHECSLDDTSL-LIPIIVGAALAGLIFIVVIAYVIGRRRTYVGYQTL 355
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Match: lamp1 (lysosomal-associated membrane protein 1 [Source:NCBI gene;Acc:100216290])

HSP 1 Score: 63.929 bits (154), Expect = 9.218e-11
Identity = 64/218 (29.36%), Postives = 98/218 (44.95%), Query Frame = 1 
Query:  163 YVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNW--NMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            YV N S +  C+L  +  + NV Y ++K   N     N     +  V  DG+C  +T  + +S  +VH + N+  N S+ + + + +S   +NT+L  +A+          + N       K F       C     L    N T   V    LQ Q F     +G    +  EC +D     +VP++VG  L G+++IV+I YLIGR R  A YQTI
Sbjct:  188 YVVNGS-SGPCLLAKVGLQMNVTY-ITKDGKNGTYVFN---IDSKGVAVDGNCTNTTASLFLSSGSVHLTFNFTLNNSLDVFYLDGVS---LNTDLPADANDTRSFHAENSSLNYMQTNAHKSFK------CNSKQPLQITSNFT---VNTYNLQVQAFNI---DGTKFATPVECSLDE-NGMLVPIVVGAALAGLVLIVLIAYLIGRKRSHAGYQTI 384
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Match: lamp1 (lysosomal-associated membrane protein 1 [Source:NCBI gene;Acc:100216290])

HSP 1 Score: 63.929 bits (154), Expect = 9.282e-11
Identity = 64/218 (29.36%), Postives = 98/218 (44.95%), Query Frame = 1 
Query:  163 YVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNW--NMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            YV N S +  C+L  +  + NV Y ++K   N     N     +  V  DG+C  +T  + +S  +VH + N+  N S+ + + + +S   +NT+L  +A+          + N       K F       C     L    N T   V    LQ Q F     +G    +  EC +D     +VP++VG  L G+++IV+I YLIGR R  A YQTI
Sbjct:  216 YVVNGS-SGPCLLAKVGLQMNVTY-ITKDGKNGTYVFN---IDSKGVAVDGNCTNTTASLFLSSGSVHLTFNFTLNNSLDVFYLDGVS---LNTDLPADANDTRSFHAENSSLNYMQTNAHKSFK------CNSKQPLQITSNFT---VNTYNLQVQAFNI---DGTKFATPVECSLDE-NGMLVPIVVGAALAGLVLIVLIAYLIGRKRSHAGYQTI 412
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Match: lamp1 (lysosomal-associated membrane protein 1 [Source:NCBI gene;Acc:100216290])

HSP 1 Score: 63.929 bits (154), Expect = 1.011e-10
Identity = 64/218 (29.36%), Postives = 98/218 (44.95%), Query Frame = 1 
Query:  163 YVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNW--NMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            YV N S +  C+L  +  + NV Y ++K   N     N     +  V  DG+C  +T  + +S  +VH + N+  N S+ + + + +S   +NT+L  +A+          + N       K F       C     L    N T   V    LQ Q F     +G    +  EC +D     +VP++VG  L G+++IV+I YLIGR R  A YQTI
Sbjct:  233 YVVNGS-SGPCLLAKVGLQMNVTY-ITKDGKNGTYVFN---IDSKGVAVDGNCTNTTASLFLSSGSVHLTFNFTLNNSLDVFYLDGVS---LNTDLPADANDTRSFHAENSSLNYMQTNAHKSFK------CNSKQPLQITSNFT---VNTYNLQVQAFNI---DGTKFATPVECSLDE-NGMLVPIVVGAALAGLVLIVLIAYLIGRKRSHAGYQTI 429
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Match: lamp2 (lysosomal-associated membrane protein 2 [Source:NCBI gene;Acc:779509])

HSP 1 Score: 55.4546 bits (132), Expect = 5.314e-8
Identity = 48/210 (22.86%), Postives = 97/210 (46.19%), Query Frame = 1 
Query:  181 LNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            +N  C+L ++  + N       K  N+    N        +  +G+C   T  + ++     NST    ++ +++ N    K +N  L+  + S+     NL  W         E ++   ++C K   +  +E+   +V+    ++ Q F  K+   +   + +EC+ D+    ++P+ VG VL  +II+V+++YLIGR + R  YQ++
Sbjct:  224 VNGTCLLASMGLQINTSLLSEGK--NIWTAFN---IDPTAMSKNGTCSNQTGTLILT----DNSTVIEFTLALKNKNHFYLKEVNVALINGSASSTRQNQNLSAW---------EASVGSSYMCHKEQQIKVSED---LVINSFDVRVQLFGVKN---ETFATAEECLADSDLSFLIPIAVGAVLVFLIILVLVSYLIGRRKSRTGYQSV 409
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Match: lamp2 (lysosomal-associated membrane protein 2 [Source:NCBI gene;Acc:779509])

HSP 1 Score: 53.9138 bits (128), Expect = 1.797e-7
Identity = 47/210 (22.38%), Postives = 96/210 (45.71%), Query Frame = 1 
Query:  181 LNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            +N  C+L ++  + N       K  N+    N        +  +G+C   T  + ++     NST    ++ +++ N    K +N  L+  + S+     NL  W         E ++   ++C K   +  +E+   +V+    ++ Q F  K+   +   +  +C +D  +  ++P++VG  L G+I+I++I YLIGR +  + YQT+
Sbjct:  224 VNGTCLLASMGLQINTSLLSEGK--NIWTAFN---IDPTAMSKNGTCSNQTGTLILT----DNSTVIEFTLALKNKNHFYLKEVNVALINGSASSTRQNQNLSAW---------EASVGSSYMCHKEQQIKVSED---LVINSFDVRVQLFGVKN---ETFATAQQCSLDD-DSIVIPIVVGAALAGLIVIIVIAYLIGRRKGYSGYQTL 408
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Mouse
Match: Lamp1 (lysosomal-associated membrane protein 1 [Source:MGI Symbol;Acc:MGI:96745])

HSP 1 Score: 65.0846 bits (157), Expect = 3.138e-11
Identity = 61/204 (29.90%), Postives = 97/204 (47.55%), Query Frame = 1 
Query:  274 NQTQFKNAVVQADGSCLLSTNVMQ--ISWPAVHNST---NWNMSIRIEHT-----NAISFKIMNTNLMIEADSNFPGITNL-----VTWNLT-GEIVTKEFTLKDYFICTKPVTLN----FNENDTKVVVKILYL-----QFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            N T  K  V   +G+CLL++  +Q  I++    N T    +N+S     +     N ++ K+ N N  +E        ++L     V  N+T  + +   F++ ++ +     T+      N  +   V K+L L     Q Q F+  S   D  GS +ECV D     ++P+ VGG L G+++IV+I YLIGR R  A YQTI
Sbjct:  207 NPTVSKYNVTGNNGTCLLASMALQLNITYLKKDNKTVTRAFNISPNDTSSGSCGINLVTLKVENKNRALELQFGMNASSSLFFLQGVRLNMTLPDALVPTFSISNHSLKALQATVGNSYKCNTEEHIFVSKMLSLNVFSVQVQAFKVDS---DRFGSVEECVQDG-NNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI 406
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Mouse
Match: Lamp2 (lysosomal-associated membrane protein 2 [Source:MGI Symbol;Acc:MGI:96748])

HSP 1 Score: 50.8322 bits (120), Expect = 1.148e-6
Identity = 23/53 (43.40%), Postives = 38/53 (71.70%), Query Frame = 1 
Query:  652 GDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            G Y+ ++ EC +D  +  ++P+IVG  L+G+II+++I YLIGR +  A YQT+
Sbjct:  365 GQYSTAQ-ECSLDD-DTILIPIIVGAGLSGLIIVIVIAYLIGRRKTYAGYQTL 415
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Match: sp|P05300|LAMP1_CHICK (Lysosome-associated membrane glycoprotein 1 OS=Gallus gallus OX=9031 GN=LAMP1 PE=2 SV=1)

HSP 1 Score: 67.781 bits (164), Expect = 2.833e-11
Identity = 34/80 (42.50%), Postives = 49/80 (61.25%), Query Frame = 1 
Query:  571 NFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            NF   D K +V +  +Q Q F+    +GD  G+ +EC +D     ++P+IVG  L G+++IV+I YLIGR R  A YQTI
Sbjct:  340 NFQVTD-KALVNVFNVQVQAFKV---DGDKFGAMEECQLDE-NNMLIPIIVGAALAGLVLIVLIAYLIGRKRSHAGYQTI 414
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Match: sp|P14562|LAMP1_RAT (Lysosome-associated membrane glycoprotein 1 OS=Rattus norvegicus OX=10116 GN=Lamp1 PE=1 SV=1)

HSP 1 Score: 66.6254 bits (161), Expect = 6.373e-11
Identity = 32/72 (44.44%), Postives = 45/72 (62.50%), Query Frame = 1 
Query:  595 VVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            + + +  +Q Q FR +S   D  GS +ECV D     ++P+ VGG L G+++IV+I YLIGR R  A YQTI
Sbjct:  340 LALNVFSVQVQAFRVES---DRFGSVEECVQDG-NNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI 407
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Match: sp|P11438|LAMP1_MOUSE (Lysosome-associated membrane glycoprotein 1 OS=Mus musculus OX=10090 GN=Lamp1 PE=1 SV=2)

HSP 1 Score: 65.0846 bits (157), Expect = 2.195e-10
Identity = 61/204 (29.90%), Postives = 97/204 (47.55%), Query Frame = 1 
Query:  274 NQTQFKNAVVQADGSCLLSTNVMQ--ISWPAVHNST---NWNMSIRIEHT-----NAISFKIMNTNLMIEADSNFPGITNL-----VTWNLT-GEIVTKEFTLKDYFICTKPVTLN----FNENDTKVVVKILYL-----QFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            N T  K  V   +G+CLL++  +Q  I++    N T    +N+S     +     N ++ K+ N N  +E        ++L     V  N+T  + +   F++ ++ +     T+      N  +   V K+L L     Q Q F+  S   D  GS +ECV D     ++P+ VGG L G+++IV+I YLIGR R  A YQTI
Sbjct:  207 NPTVSKYNVTGNNGTCLLASMALQLNITYLKKDNKTVTRAFNISPNDTSSGSCGINLVTLKVENKNRALELQFGMNASSSLFFLQGVRLNMTLPDALVPTFSISNHSLKALQATVGNSYKCNTEEHIFVSKMLSLNVFSVQVQAFKVDS---DRFGSVEECVQDG-NNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI 406
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Match: sp|P49129|LAMP1_CRIGR (Lysosome-associated membrane glycoprotein 1 OS=Cricetulus griseus OX=10029 GN=LAMP1 PE=2 SV=1)

HSP 1 Score: 63.5438 bits (153), Expect = 5.822e-10
Identity = 30/70 (42.86%), Postives = 44/70 (62.86%), Query Frame = 1 
Query:  601 VKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            + +  +Q Q F+ +S   D  GS +EC+ D     ++P+ VGG L G+++IV+I YLIGR R  A YQTI
Sbjct:  342 LNVFSVQVQAFKVES---DRFGSVEECMQDG-NNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI 407
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Match: sp|Q05204|LAMP1_BOVIN (Lysosome-associated membrane glycoprotein 1 OS=Bos taurus OX=9913 GN=LAMP1 PE=1 SV=2)

HSP 1 Score: 60.4622 bits (145), Expect = 7.736e-9
Identity = 28/63 (44.44%), Postives = 39/63 (61.90%), Query Frame = 1 
Query:  622 FQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
             Q FR    +GD  G  +EC +D     ++P+ VGG L G+++IV++ YLIGR R  A YQTI
Sbjct:  351 LQAFRV---DGDKFGPVEECQLDE-NSMLIPIAVGGALAGLVLIVLLAYLIGRKRSHAGYQTI 409
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Match: K1RMK6 (Lysosome-associated membrane glycoprotein 1 OS=Crassostrea gigas OX=29159 GN=CGI_10016609 PE=3 SV=1)

HSP 1 Score: 76.2554 bits (186), Expect = 1.228e-11
Identity = 46/132 (34.85%), Postives = 68/132 (51.52%), Query Frame = 1 
Query:  433 NTNLMIEADSNFPG------ITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            N+NL + AD +  G        NL  W  TG+  +        ++C K  T+N +  D    + +  +Q+Q F+ K N+ D+ G   EC  D     IVP+ VG  L G++IIV+I YLIGR R RA Y+ +
Sbjct:  265 NSNLFVTADESILGKKAKFTAANLTLWE-TGKGKS--------YMCNKESTINLSSKDG-FELTVSKVQYQAFK-KGNSNDF-GDASECAADEETNSIVPIAVGAALAGLVIIVLIAYLIGRKRSRAGYEQV 384
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Match: A0A3Q3MGI1 (Lysosomal associated membrane protein 1b OS=Mastacembelus armatus OX=205130 PE=3 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 1.294e-11
Identity = 58/212 (27.36%), Postives = 96/212 (45.28%), Query Frame = 1 
Query:  190 ACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEF-----TLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            AC+L ++  + N+ +K   +   V   +N    +  + ++ GSC   T  +Q++  A      +  ++     N  S K   + + + A           +W   GE   +       TL   ++C K  TLN  +N   V +    LQ Q F      GD   + +EC +D  +  ++P+IVG  L G++IIV++ YLIGR R  A YQTI
Sbjct:   47 ACLLASMGLQLNITFKSVPQNKTVQDVVN---LQPNLTKSSGSCESDTASLQLTTDADKTILTFVFTL-----NTTSHKYHLSEVSLSA-----------SWPDKGEFHNRSLNYMRGTLGYSYMCHKEQTLNVAQN---VSINTFQLQVQPF---GLTGDKFAAAEECQLDE-DDMLIPIIVGAALAGLVIIVLLAYLIGRKRSHAGYQTI 232
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Match: A0A151JZ13 (Lysosome-associated membrane glycoprotein 1 OS=Trachymyrmex septentrionalis OX=34720 GN=ALC56_03977 PE=3 SV=1)

HSP 1 Score: 75.0998 bits (183), Expect = 1.912e-11
Identity = 65/210 (30.95%), Postives = 97/210 (46.19%), Query Frame = 1 
Query:  184 NDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFT--LKDYFICTKPVTLNFNENDTKV-VVKILYLQFQGFRSKSNNGDYT---GSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRA 795
            N  C+L+ ++ +FNV Y +     NV  Y       N    A G C  +   + +SW + +N+T  N +I         +  ++   +  A   FP   N     +T   VT +F   L + + C K   LN   N+  V  +KI  LQFQ FR     GD T   G   +C  D  +  IVP+ VG  L G+++IV+I YL+GR R +A
Sbjct:  138 NTICILIKMAVQFNVSYTID----NVTIYKVMDVPSNG--NATGKCDKTEQNLTLSWESQNNTTQDNFTIHFVKNETEKYYSLHHFEISLAAEEFPN--NKSNKTVTVVHVTPQFKTGLSNSYKCIKEQQLNLTHNNVTVGFLKITNLQFQAFR-----GDNTTIFGLAKDCSFDTPD--IVPITVGCALAGLVVIVLIAYLVGRRRSQA 332
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Match: A0A1S8WJP4 (Lysosome-associated membrane glycoprotein OS=Opisthorchis viverrini OX=6198 GN=X801_09541 PE=3 SV=1)

HSP 1 Score: 73.9442 bits (180), Expect = 2.791e-11
Identity = 65/243 (26.75%), Postives = 119/243 (48.97%), Query Frame = 1 
Query:  145 KSVVKFYVTNDSLNDACMLLTISAEFNVQYKVSK-KPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISW----PAVHNSTNWNMSI----RIEHTNAISFKIMN--TNLMIEADSNFPGITNLVTWNLTGEIVTKEFT--LKDYFIC--------TKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
             +V  + V+N +  D C+L+ ++ +  + Y  +K +P     Y+N T  +N  V  +G+C +    + ++W    P V ++ +W++ +    R +   ++ F +++  TN  +  D+N   I + V+ N        +FT  +  YF C        TKP ++       +V V +  L+ + FRS  N   + GS  EC  D +  ++VP++VG  L  MIII +IT++I   R +  YQ I
Sbjct:   59 PTVPSYNVSNGT--DICLLVQMNIKLGITYFNTKGEPLMRNFYINST--RNFDVVTNGTCGIELETLMLTWWPEQPQVKDAPSWSLGLQFHKRADGHFSLDFMVLSYITNTSLFPDTNETSI-HYVSRN------GSQFTCPVGSYFQCMASQSSKLTKPSSVKDPIVQPEVFVTLSDLKAEAFRS-GNTPTFVGSMRECSADYVPNKVVPIVVGVALAAMIIIALITFVISSRRRQRGYQEI 289
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Match: A0A1S3IH56 (LAMP family protein lmp-1 OS=Lingula unguis OX=7574 GN=LOC106163698 PE=3 SV=1)

HSP 1 Score: 72.7886 bits (177), Expect = 9.445e-11
Identity = 60/223 (26.91%), Postives = 103/223 (46.19%), Query Frame = 1 
Query:  160 FYVTNDSLNDACMLLTISAEFNVQY-KVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSN----FPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDE-CVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            F V+N S++  C++L ++A+F ++Y  V  K  +    L      N+    +G+CL +   + I+     N+ +  M    +  N     +   N  +E ++     FP  T+ V  +  G     +  +  Y+ C   +   F   D KV V I  L+   F   +   D+ G K+  C+ D     IVP+ VG  L G+++IV+I YLIGR  +R  YQ++
Sbjct:  101 FVVSNGSVD--CIILQMNAQFTIKYMDVENKTKDAKFILPH----NSSAAVEGNCLNALETITINM--YDNAVSMTMRFTNDGNN-----VALANATVEYNTKDSTVFPNATD-VKNSSNGHFDNVQAPVNSYYRCNSAINPTF---DDKVSVTITNLKVTAFNQNNKTDDFGGGKETVCLADTQTDNIVPIAVGAALAGLVVIVLIAYLIGRRTNRQGYQSV 306
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Cavefish
Match: lamp1a (lysosomal associated membrane protein 1 [Source:NCBI gene;Acc:103047616])

HSP 1 Score: 66.2402 bits (160), Expect = 1.071e-11
Identity = 57/214 (26.64%), Postives = 98/214 (45.79%), Query Frame = 1 
Query:  193 CMLLTISAEFNVQYKVSKKPYNVMGYLN----QTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTK----PVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            C+L  +  + NV Y    +   V G +N    +T F  +      + +L+  +  +++    NST+     ++ H +A+S        M  A  + P    L   +L       + +L   ++C      PV  +F+ N  +       LQ Q F     NG+  G+ +EC +D  +  ++P+IVG  L G+++IV++ YLIGR R  A YQTI
Sbjct:  226 CLLAKMGLQLNVTYISKTQNKTVQGIVNLQPNRTTFSGSCEDTTATLILTDELTNLTFTFTLNSTS-----KMYHLSALS--------MSAAWPDMPAPVTLSNSSLN----YLQGSLGRSYMCRSEQILPVVDSFSLNTFR-------LQVQPF---GVNGNQFGTAEECQMDQ-DNMLIPIIVGAALAGLVLIVLVAYLIGRKRSHAGYQTI 411
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Cavefish
Match: lamp2 (lysosome-associated membrane glycoprotein 2 [Source:NCBI gene;Acc:103021444])

HSP 1 Score: 58.9214 bits (141), Expect = 2.110e-9
Identity = 56/214 (26.17%), Postives = 93/214 (43.46%), Query Frame = 1 
Query:  229 QYKVSKKPYNV-----MGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIE---------------HTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
             Y V   P +V     MG     QF+  + ++  +  L  NV   S    +N ++  +S++ E               H  A++F + N N       N    +N+  W         E +L   ++C K  T N +++   +V+    LQ Q F    N      + +EC +DA    +VP+ VG  L  +II+V+I+YLIGR + R  YQ++
Sbjct:  188 DYNVGPDPKSVCLKAKMGL----QFRYKLGESFQTINLDPNVTHYSGLCGNNGSDSTLSLKSELITVQFLFVNQSNKFHLGAMNFTLRNGNETTFDRRN----SNMSLW---------EASLGSSYMCRKEQTFNISDD---LVMNTFELQVQPFGVTENKF---STAEECFLDADLSFLVPIAVGVALGFLIILVLISYLIGRRKSRTGYQSV 378
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Cavefish
Match: lamp2 (lysosome-associated membrane glycoprotein 2 [Source:NCBI gene;Acc:103021444])

HSP 1 Score: 55.8398 bits (133), Expect = 2.013e-8
Identity = 32/96 (33.33%), Postives = 51/96 (53.12%), Query Frame = 1 
Query:  523 EFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            E +L   ++C K  T N +++   +V+    LQ Q F    N      +  EC +D     ++P+IVG  L G+I+IV+I Y+IGR +    YQT+
Sbjct:  289 EASLGSSYMCRKEQTFNISDD---LVMNTFELQVQPFGVTENKF---STAHECSMDDTSL-LIPIIVGAALAGLILIVVIAYVIGRRKTYVGYQTL 377
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Sea Lamprey
Match: ENSPMAT00000009947.1 (pep scaffold:Pmarinus_7.0:GL478277:66156:69514:-1 gene:ENSPMAG00000008999.1 transcript:ENSPMAT00000009947.1 gene_biotype:protein_coding transcript_biotype:protein_coding)

HSP 1 Score: 50.447 bits (119), Expect = 1.690e-7
Identity = 44/207 (21.26%), Postives = 93/207 (44.93%), Query Frame = 1 
Query:  190 ACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            AC+L+ ++ E  V+   +K    V+          +   A G C  +T+++ +++     +  +  S +  H + IS         I+   + P   N       G +      L   ++C      +  +   ++++ +  L+ Q F+ ++   D   + +EC  D +   ++P+IVG VL  +I++V++ YLIGR ++   YQ+I
Sbjct:   87 ACLLVDVALEVQVEDSQNKTHIFVV--------HPSRTSASGHCQSTTSLLNLTFAEGFIAFTFTTSNKRFHLDQIS---------IDLKLHIPDAPNDTFVGSKGNLTLFPANLGSSYMCKAKQNESIGD---QILLMVSDLRLQPFKVQN---DAFSTAEECTRD-VGGVLIPIIVGSVLASLIVVVLVAYLIGRRKNHTGYQSI 269
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Nematostella
Match: EDO45266 (Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7RTH6])

HSP 1 Score: 53.1434 bits (126), Expect = 3.661e-8
Identity = 57/251 (22.71%), Postives = 101/251 (40.24%), Query Frame = 1 
Query:  163 YVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQT---QFKNAVVQADGSCLLSTN---VMQISWPAVH---------------------NSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLK--DYFICTKPVTLNFNENDTKVVVKILYLQFQGF-RSKSNNGDYTGSKDECVIDALERQ-----IVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            Y   D     C+L  +SA FNV Y + KK  N    ++ T    F  ++V    S     N    +++ WP                        N T+WN+         I+F +  TN     + +F   T  +    +       F  K   Y+ C    +    +    V V++ +++ + F +S S N  ++G  ++C  +   ++     IVP+ VG  L G+++IV+I Y+IGR +    Y+ +
Sbjct:   31 YSVKDKQGMFCLLAQLSATFNVTY-LKKKAGNKTEEMSSTVSMPFNKSLVDTSNSKCSEENGISTLEVVWPVKEKFYKFALTFAAAESKEDSNGVNYTDWNIK-------RIAFVVNTTN-----NKDFENATERIIKVASNGTEMSGFHAKYGKYYNCAGKRSYKIEDT---VSVQLDHVKIEPFVKSPSKNETFSGDYEDCENENPSKKPDDDNIVPIAVGCALAGLVLIVLIAYIIGRRKSHRGYEKV 265
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Medaka
Match: lamp1b (lysosomal associated membrane protein 1b [Source:ZFIN;Acc:ZDB-GENE-030131-9303])

HSP 1 Score: 59.6918 bits (143), Expect = 4.881e-10
Identity = 30/89 (33.71%), Postives = 51/89 (57.30%), Query Frame = 1 
Query:  544 FICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            ++C +  TL   +   ++ +    +Q Q F      G+  G+ +EC +D  +  ++P++VG  L G++IIV++ YLIGR R  A YQTI
Sbjct:  154 YMCRQEQTLTVTK---ELSINTFQVQVQPF---GLTGEQFGAAEECQLDE-DAMLIPIVVGAALAGLVIIVLVAYLIGRKRSHAGYQTI 235
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Medaka
Match: lamp1a (lysosomal associated membrane protein 1 [Source:NCBI gene;Acc:101175550])

HSP 1 Score: 60.077 bits (144), Expect = 1.128e-9
Identity = 64/219 (29.22%), Postives = 92/219 (42.01%), Query Frame = 1 
Query:  178 SLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSN---FPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVK-----ILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            S+ +A   + + A+  VQ  VS        Y +Q+Q  N  VQ     LL+      S   +   TN  + +  E T  +SF        + + SN     GIT    W       +   T  DY   +   +   N   T  VV      +  LQ Q F   S       S + C ID  ++ ++P+IVG  L G+++IV+I YLIGR R  A YQTI
Sbjct:  225 SVKNASGTVCLMAKMGVQLNVS--------YFSQSQ--NKTVQE----LLNLTPNLTSSSGLCGGTNATLVLAQEETTVLSFL-----FTVNSTSNKYHLSGITLQANWTDMMSPFSASNTSLDYLRSSLGHSYMCNAEQTLFVVSTFSINMFELQVQPFGVTSTQ---FASAEVCQIDQ-DQMLIPIIVGAALAGLVLIVLIAYLIGRKRSHAGYQTI 420
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Medaka
Match: lamp2 (lysosomal associated membrane protein 2 [Source:NCBI gene;Acc:101162376])

HSP 1 Score: 48.9062 bits (115), Expect = 4.314e-6
Identity = 51/212 (24.06%), Postives = 89/212 (41.98%), Query Frame = 1 
Query:  184 NDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTN-AISFKIMNTNLMIEADSNF--PGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            N  C+L    A F V+   ++   N      +     AV +A G C  +++ +++         +  M++ +  TN A  F++   N+ ++  S     G  NL  W         E  +   ++C +    N       + +    LQ Q F  K    D   +  EC +D     ++P+IVG  L  +I+IV+I Y+IGR +    YQT+
Sbjct:  308 NTVCLL----ASFAVRISFTQAGKN-----EEMNLDPAVTKASGQCGENSSELEL--------VSDQMTLTLAFTNDAKKFRLQALNVTLKTSSGVFADGNANLSLW---------EAAIGTSYMCNREQNFNIT---NMLSLYTSNLQVQPFEVKK---DAFSTAHECSLDDTSI-LIPIIVGAALAVLILIVVIAYVIGRRKTYVGYQTL 486
[Close]
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Planmine SMEST
Match: SMESG000025677.1 (SMESG000025677.1)

HSP 1 Score: 468.774 bits (1205), Expect = 1.689e-168
Identity = 225/225 (100.00%), Postives = 225/225 (100.00%), Query Frame = 1 
Query:  136 CEPKSVVKFYVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 810
            CEPKSVVKFYVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI
Sbjct:   17 CEPKSVVKFYVTNDSLNDACMLLTISAEFNVQYKVSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNMSIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLKDYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVIDALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI 241
The following BLAST results are available for this feature:
BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Human
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Human e!99)
Total hits: 1
Match NameE-valueIdentityDescription
LAMP12.332e-941.43lysosomal associated membrane protein 1 [Source:HG... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Celegans
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Celegan e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Fly
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Drosophila e!99)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Zebrafish
Analysis Date: 2016-08-08 (Schmidtea mediterranea smed_20140614 BLASTX Zebrafish e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lamp1b1.863e-1138.30lysosomal associated membrane protein 1b [Source:Z... [more]
lamp21.955e-924.32lysosomal-associated membrane protein 2 [Source:ZF... [more]
lamp1a4.539e-943.08lysosomal associated membrane protein 1a [Source:Z... [more]
lamp1a5.788e-943.08lysosomal associated membrane protein 1a [Source:Z... [more]
lamp26.453e-924.77lysosomal-associated membrane protein 2 [Source:ZF... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Xenopus
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Xenopus e!99)
Total hits: 5
Match NameE-valueIdentityDescription
lamp19.218e-1129.36lysosomal-associated membrane protein 1 [Source:NC... [more]
lamp19.282e-1129.36lysosomal-associated membrane protein 1 [Source:NC... [more]
lamp11.011e-1029.36lysosomal-associated membrane protein 1 [Source:NC... [more]
lamp25.314e-822.86lysosomal-associated membrane protein 2 [Source:NC... [more]
lamp21.797e-722.38lysosomal-associated membrane protein 2 [Source:NC... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Mouse
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX Mouse e!99)
Total hits: 2
Match NameE-valueIdentityDescription
Lamp13.138e-1129.90lysosomal-associated membrane protein 1 [Source:MG... [more]
Lamp21.148e-643.40lysosomal-associated membrane protein 2 [Source:MG... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. UniProt/SwissProt
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI UniProt)
Total hits: 5
Match NameE-valueIdentityDescription
sp|P05300|LAMP1_CHICK2.833e-1142.50Lysosome-associated membrane glycoprotein 1 OS=Gal... [more]
sp|P14562|LAMP1_RAT6.373e-1144.44Lysosome-associated membrane glycoprotein 1 OS=Rat... [more]
sp|P11438|LAMP1_MOUSE2.195e-1029.90Lysosome-associated membrane glycoprotein 1 OS=Mus... [more]
sp|P49129|LAMP1_CRIGR5.822e-1042.86Lysosome-associated membrane glycoprotein 1 OS=Cri... [more]
sp|Q05204|LAMP1_BOVIN7.736e-944.44Lysosome-associated membrane glycoprotein 1 OS=Bos... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. TrEMBL
Analysis Date: 2020-05-01 (Schmidtea mediterranea smed_20140614 BLASTX EMBL-EBI TrEMBL)
Total hits: 5
Match NameE-valueIdentityDescription
K1RMK61.228e-1134.85Lysosome-associated membrane glycoprotein 1 OS=Cra... [more]
A0A3Q3MGI11.294e-1127.36Lysosomal associated membrane protein 1b OS=Mastac... [more]
A0A151JZ131.912e-1130.95Lysosome-associated membrane glycoprotein 1 OS=Tra... [more]
A0A1S8WJP42.791e-1126.75Lysosome-associated membrane glycoprotein OS=Opist... [more]
A0A1S3IH569.445e-1126.91LAMP family protein lmp-1 OS=Lingula unguis OX=757... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Cavefish
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Cavefish e!99)
Total hits: 3
Match NameE-valueIdentityDescription
lamp1a1.071e-1126.64lysosomal associated membrane protein 1 [Source:NC... [more]
lamp22.110e-926.17lysosome-associated membrane glycoprotein 2 [Sourc... [more]
lamp22.013e-833.33lysosome-associated membrane glycoprotein 2 [Sourc... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Sea Lamprey
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Sea Lamprey e!99)
Total hits: 1
Match NameE-valueIdentityDescription
ENSPMAT00000009947.11.690e-721.26pep scaffold:Pmarinus_7.0:GL478277:66156:69514:-1 ... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Yeast
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Yeast e!Fungi46)
Total hits: 0
Match NameE-valueIdentityDescription
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Nematostella
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Nematostella e!Metazoa46)
Total hits: 1
Match NameE-valueIdentityDescription
EDO452663.661e-822.71Predicted protein [Source:UniProtKB/TrEMBL;Acc:A7... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Ensembl Medaka
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Medaka e!99)
Total hits: 3
Match NameE-valueIdentityDescription
lamp1b4.881e-1033.71lysosomal associated membrane protein 1b [Source:Z... [more]
lamp1a1.128e-929.22lysosomal associated membrane protein 1 [Source:NC... [more]
lamp24.314e-624.06lysosomal associated membrane protein 2 [Source:NC... [more]
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BLAST of Lysosome-associated membrane glycoprotein 2 vs. Planmine SMEST
Analysis Date: 2020-05-08 (Schmidtea mediterranea smed_20140614 BLASTX Planmine SMEST)
Total hits: 1
Match NameE-valueIdentityDescription
SMESG000025677.11.689e-168100.00SMESG000025677.1[more]
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Sequences
The following sequences are available for this feature:

transcript sequence

>SMED30018188 ID=SMED30018188|Name=Lysosome-associated membrane glycoprotein 2|organism=Schmidtea mediterranea sexual|type=transcript|length=1009bp
TAATTGACCAATTTATTTAAAATTACTTGTTTGAATTATCCTCTTATAAT
CATTACTTTTAATTATTCATTCCGAATAACATCAAAAATGCTATTTATTT
CTTATTTACTATTATTTCTTATATCAGTTATTAGTTGCGAACCAAAATCA
GTAGTGAAATTTTATGTTACAAATGATTCTTTAAATGATGCATGTATGTT
GCTCACTATTTCGGCTGAATTCAATGTTCAATATAAAGTTTCTAAAAAAC
CATATAATGTTATGGGGTATCTTAACCAAACACAATTTAAAAATGCAGTG
GTTCAAGCCGATGGTAGTTGCTTATTGTCAACGAATGTAATGCAAATTTC
ATGGCCGGCTGTTCATAATTCCACAAACTGGAATATGTCCATCCGCATCG
AACATACAAATGCAATTAGTTTCAAGATCATGAATACAAATTTAATGATC
GAAGCAGATTCGAATTTTCCCGGAATAACGAATTTAGTGACATGGAATCT
GACTGGAGAAATAGTAACGAAGGAATTCACTTTGAAGGACTATTTTATTT
GCACTAAACCTGTAACCTTGAATTTCAATGAAAATGACACGAAAGTAGTT
GTAAAGATTCTCTACCTGCAGTTCCAGGGGTTCCGGTCCAAATCGAATAA
TGGCGACTACACTGGTTCAAAAGATGAGTGTGTCATTGATGCACTGGAGA
GACAAATAGTTCCGTTAATTGTCGGAGGCGTCCTCACAGGAATGATCATC
ATTGTCATTATCACCTATTTGATTGGCAGGCACAGGCATAGGGCCAATTA
TCAAACGATTTAATTTATTAAATGCAATATCCAGTCTCTCATTGATTGTG
TAATTATGCTGTCCTATTGATTTGATAGAGATTTTTGTATCGTTTCCAAT
TTTGTCATAAATAGATAATTATTGTTAGTTTTGTGATTGATTGTTATTCG
ATCCAGTTTTAGAGAATTTTTGAATCGATAACATCTGTAATTAGAAATTT
GTAAATGAG
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protein sequence of SMED30018188-orf-1

>SMED30018188-orf-1 ID=SMED30018188-orf-1|Name=SMED30018188-orf-1|organism=Schmidtea mediterranea sexual|type=polypeptide|length=242bp
MLFISYLLLFLISVISCEPKSVVKFYVTNDSLNDACMLLTISAEFNVQYK
VSKKPYNVMGYLNQTQFKNAVVQADGSCLLSTNVMQISWPAVHNSTNWNM
SIRIEHTNAISFKIMNTNLMIEADSNFPGITNLVTWNLTGEIVTKEFTLK
DYFICTKPVTLNFNENDTKVVVKILYLQFQGFRSKSNNGDYTGSKDECVI
DALERQIVPLIVGGVLTGMIIIVIITYLIGRHRHRANYQTI*
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Annotated Terms
The following terms have been associated with this transcript:
Vocabulary: cellular component
TermDefinition
GO:0005764lysosome
GO:0005765lysosomal membrane
GO:0016020membrane
GO:0016021integral component of membrane
Vocabulary: Planarian Anatomy
TermDefinition
PLANA:0000020protonephridia
PLANA:0000026gut
PLANA:0000070intestinal phagocyte
PLANA:0002056medial muscle cell
PLANA:0003116parenchymal cell
Vocabulary: INTERPRO
TermDefinition
IPR002000Lysosome-assoc_membr_glycop
InterPro
Analysis Name: Schmidtea mediteranean smed_20140614 Interproscan
Date Performed: 2020-05-01
IPR TermIPR DescriptionSourceSource TermSource DescriptionAlignment
IPR002000Lysosome-associated membrane glycoproteinPRINTSPR00336LYSASSOCTDMPcoord: 205..227
score: 40.06
coord: 25..49
score: 20.0
coord: 190..202
score: 29.12
IPR002000Lysosome-associated membrane glycoproteinPANTHERPTHR11506LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINcoord: 20..241
IPR002000Lysosome-associated membrane glycoproteinPROSITEPS51407LAMP_3coord: 1..241
score: 16.191
NoneNo IPR availableGENE3DG3DSA:2.40.160.110coord: 20..205
e-value: 7.4E-9
score: 37.8
NoneNo IPR availableSIGNALP_EUKSignalP-noTMSignalP-noTMcoord: 1..17
score: 0.879
NoneNo IPR availableTMHMMTMhelixcoord: 207..229